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    公开号:WO1981003657A1
    申请号:PCT/EP1981/000066
    申请日:1981-06-09
    公开日:1981-12-24
    发明作者:G Bellmann；V Nguyen
    申请人:Battelle Memorial Institute；
    IPC主号:C07C69-00
    专利说明:
    [0001] UNSATURATED ESTERS OF ADAMANTANE CONTAINING DIOLS AND THERMO-RESISTANT CROSS-LINKED POLYMERS THEREFROM
    [0002] 1. FIEID OF INVENTION
    [0003] The present invention concerns new unsaturated esters (I) of adamantane diols and of adamantane containing dihydroxy-compounds (II), the polymerizaticn thereof and the cross-linked polymers resulting fron such polymerization..
    [0004] The new ester mcnomers have the formula (I),
    [0005]
    [0006] Wherein the R and R' are hydrogen or methyl group and A is either a sigma (σi bond, a radical satisfying the formula (CH2)n, a phenylene or an alkyl derivative thereof.
    [0007] What follcws is LIST I which lists some specific examples from FORMULA (I) ;
    [0008] LIST I
    [0009] 1. Diacrylate and dimethacrylate esters of 1,3-adamantane diol R = H; R' = H, CH3; A = sigma ( σ) bond
    [0010] 2. Diacrylate and dimethacrylate esters of 1,3-dimethyl-5,7-ada mantane diol
    [0011] R = CH3; R' = H, CH3; A = sigma ( σ) bond
    [0012] 3. Diacrylate and dimethacrylate esters of 1,3-bis-(hydroxymethyl) adamantane
    [0013] R = H R' = H, CH3; A = - CH2-
    [0014] 4. Diacrylate and dimethacrylate esters of 1,3-dimethyl-5 ,7-bis-(hydroxymethyl) -adamantane R = CH3; R' = H, CH3; A = -CH2-
    [0015] 5. Diacrylate and dimethacrylate esters of 1 ,3-bis-(2-hydroxyethyl) -adamantane
    [0016] R = H; R' = H, CH3; A = -CH2-CH2-
    [0017] 6. Diacrylate and dimethacrylate esters of 1,3-dimethyl-5 ,7-bis- (2-hydroxyethyl) -adamantane
    [0018] R = CH3; R' = H, CH3; A = -CH2-CH2-
    [0019] 7. Diacrylate and dimethacrylate esters of 1,3-bis-(p-hydroxyphenyl)-adamantane
    [0020] 8. Diacrylate and dimethacrylate esters of 1,3-dimethyl-5 ,7-bis-(p-hydroxyphenyl)-adamantane
    [0021] Thus, the new monomers of the invention, i.e. the acrylic and methacrylic esters of the corresponding di-hydroxy containing adamantanes (II), are bifuncticnal, compounds, a condition for obtaining, by the polymerization thereof, cross-linked type resins having unusual hardness, inertness to degradation agents and resistance to heat.
    [0022] 2. SUMMARY OF THE PRIOR ART.
    [0023] Esters of unsaturated acids and hydroxy-containing adamantane compounds are already known. Thus, DULING et al (USP 3,533,947 and 3,639,362) disclose the mono-acrylates of 1-hydroxy-adamantane and of other hydroxy-adamantanes alkylated on the others bridge-head positions of the cage. Also S.S. NOVIKOV et al, Izvestiya Akademii Nauk SSSR, [12] 2765, (1977), report the preparation of acrylates and methacrylates of mono substituted adamantane corpounds of formula HO-R-Ad in which Ad represents the adamantane cage and R represents the groups methylene, ethylene, -CH2-CH2-O-CO-, -CH 2-CH2-O-CO-CH2-. Also, REINHARDT (USP 3,342,880) discloses the preparation and the polymerizaticn of adamantyl methacrylate and of
    [0024] 3,3'-dimethylacryl-1,1'-bis-adamantane, the latter giving a cross-linked resin.
    [0025] Now, all the monofuncticnal monomers of the above prior-art provide straight chain polymer resins the properties of which do not come up to the level of cross-linked polymers and the difuncticnal mononer mentioned above, although it provides a cross-linked polymer, is rather expensive and not well suitεd for industrial developments.
    [0026] OBJECTS OF THE INVENTION
    [0027] Thus, one object of the present inventicn is to provide new adamantane mononers containing two olefinic groups suitable for making, by polymerizaticn, or copolymerization with other mononers, cross-linked resins with unusual physical properties.
    [0028] Another object of the invention is to provide adamantane polymerizable difuncticnal mononers, the adamantane cage of which is separatem fron the polymerizable functioi by means of a ccnnecting chain the length of which can be varied in order that polymers and copolymers with a ränge of properties can be obtained by using appropriate mixtures of different mononers and copolymerizing such mixtures.
    [0029] Still another object of the invention is to prcpose new difuncticnal adamantane moncmers which can be preparsd according to well defined and relatively inexpertsive routes. Still another object of the invention is to furnish difunctional adamantane polymerizable monomers which can easily and cheaply be polymerized by different methods, i.e. thermally, by means of free radicals or photcchemically, thus ensuring a great versatility of end-uses.
    [0030] Other objects of the invention will become apparent to those skilled in the art from the detailed discussion that follows:
    [0031] DEFINITION OF THE INVENTION
    [0032] The preferred compounds in the inventicn are the acrylates and methacrylates of 1,3-adamantane diol, of 1,3-bis(hydroxymethyl)-a-damantane, of 1,3-bis(2-hydroxyethyl)-adamantane; of 1,3-bis-(p-hydroxyphenyl)-adamantane, and also the corresponding homologs with methyl groups in positicn 5 and 7 of the adamantane cage. All these mononers are liquids or solids which can be polymerized easily either thermally (around 150°C) or in the presence of radical initiators such as H2O2, organic peroxides such as benzoyl peroxide, dicumyl peroxide, lauroyl peroxide or azobis-isobutyronitrile and other cormon Initiators. These monomers can also be polymerized by irradiation with actinic sources stich as ultraviolet light (prefe rably below 320 ran) , and electron beams. Ihe monomers can be polymerized either individually or copolymerized as mixtures of two or several other monomers. Said other monomers can be selected from difunctional mononers according to the inventicn or from monomers of the prior-art including monofunctional mononers or polyfuncticnal monomers. Among the monofunctional monomers, acrylic acid, acrylamide, and alkyl acrylates can be menrtioned; among the polyfuncticnal mononers, ethylene glycol diacrylate, hexanediol diacrylate, and trimethylol propane triacrylate can be mentioned. The ratio of PTMM to the copolymers may ränge from 1:0 to 1:1. The polymers of the invention are hard, transparent resins which resist attack by heat and solvents and which have many end-uses. Depending on the method of polymerization, hardnesses in the ränge of 30 (KNOOP) and more can be attained and the weight losses on being subjected to tenperatures in the ränge of 400-450°C are only about cne third of the losses for cross-linked resins fron conventional monomers.
    [0033] Therefore, the new resins can be used in many high teπperatu re applicaticns and, also, for improving the scratch and solvent resistance of organic glasses by means of coatings only a few microns thick.
    [0034] SOME ILLUSTRATIVE EMBODIMENTS OF THE INVENTION
    [0035] The new monomers of the invention can be obtained according to several different routes sσne of which will be summarized in the following text below by way of illustration.
    [0036] Adamantane itself is available commercially and is generally obtained frcm the catalyzed rearrangement of tricyclic compounds. Thus, for instanca, the bridge-head dimethyl hydrocarbon can be obtained from acenaphtene by hydrogenaticn and sucsequent
    rearrangement in the presence of lewis acids
    [0037]
    [0038] Another similar method consists in the hydrogenation of dime
    thyl dicyclopentadiene and the subsequent rearrangement of the hydrogenäted tricyclo compound into dimethyladamantane
    [0039]
    Then, dimethyl adamantane can be oxidized
    with
    [0040] CrO3 in acetic acid to the corresponding diol (Ila) such as describ ed, for instance in French Patent No 1.461.287 , or brcminated to the corresponding dibromo-compound (III) with bromine in the presence of boren tribromide and AlBr3 .
    [0041]
    [0042] The dibromo-compound (III) , as well as the diol (Ila) , can be cenverted to the corresponding dicarboxylic acid by reacticn with formic acid in concentrated H2SO4 ,
    then the diacid is esterified with a lower alcohol and the octained es
    ter is reduced to the corresponding diol (Ilb) with lithium alumi niun hydride
    [0043]
    Alternatively, the dibromo-compound (III) can be converted to the corresponding diacetic acid derivative (IV) , for instance by hea
    ting with vinylidene Chloride in sulfuric acid according to K. BOTT, Chem.Ber. 101, 564-573 (1968) . The diacid being thereafter esterified and the ester reduced with LiAlH4 in a manner analcgous to reactions and above (reactions and )



    to give the dimethylol compound (IIc) .
    [0044]
    [0045] However , since the sequence of reactions
    does not provide very good yields, a two stage analogous sequence of reactions involving the corresponding monobromo-adamantane derivative is preferably used. In this sequence, dimethyl adamantane is first monobrominated using refluxing bromine (reaction
    ) and the dimethyl-bromo-adamantane is converted to the mono-methyl-carboxylic acid by the same type of reaction as reacticn above, after which the
    mono-carboxylic compound is brominated yielding 1-bromo-3-carboxymethyl-5,7-dimethyl adamantane which then is once more reacted with vinylidene Chloride in H2SO4 according to to give, finally, the
    diacetic acid (IV) :
    [0046]
    [0047] The dibromo-dimethyl-adaraantane (III) can also be reacted with phenols according to the conditions disclosed in LSP 3,594 ,427 (reaction ) to give the desired bishydroxyphenyl compounds (Ild) . This is illustrated by the following scheme involving ordinary unsubsti tuted phenol:
    [0048]
    [0049] It should be pointed out that the same reactions can be used for obtaining the corresponding non-methylated adamantane bishydro xy-compounds Now, the compounds of formula (II) can be converted to the mononers (I) by esterification, preferably with acrylyl chloride or methacrylyl chloride in the presence of a tertiary amine, according to well known techniques (see for example CSP 3,533,947). The reaction is carried out by dissolving the alcohol in a solvent such as benzene, toluene tetrahydrofurane or the like, adding a tertiary amine to the mixture in molar excess relative to the alcchol, and than slowly adding the acid chloride thereto. The amine used preferably is triethylamine, although other tertiary amines such as pyridine, tributylamine, N,N,N' ,N'-tetramethyl-ethylenediamine, triethylenediamine, picolines, quinoline and the like can be employed. Upon addition of the acid chloride, the initial reaction that takes place involves the formaticn of a coiplex between it and the amine. Slow addition of the acid chloride is continued preferably until the a- mount added is in molar excess of the alcchol. The resulting slurry is then stirred at a temperature in the ränge of 10-80°C, preferably 20-60°C, to effect the esterification reacticn. A temperature above 80°C should be avoided in most instances as this tends to cause a messy reacticn, and it is most preferable to maintain the tenperature in the ränge of 25-60°C. Time required for completion of the reacticn will depend upen the reacticn tenperature used, but generally is in the ränge of 1-20 hours.
    [0050] As the reacticn cecurs the amine-aeid chloride coiplex is replaced by an amine HCl complex which is insoluble in the solvent. ϊhe alkyladamantyl-acrylate product on the other hand remains in solution. After completion of the reaction, the mixture is filtered to remove the amine-HCl coiplex and the solvent is ranoved by evaporation. The crude product ester obtained is a nearly colorless liquid or solid which can be purified by liquid partition chronatography, by column chromatography (on Al2O3) or, when crvstallization occurs, by recrysta11ization in a suitable solvent. The purified products are colorless liquids or solids. In the absence of suitable stabilizing additives, the liquids may, in seme cases, polymerize spontaneously on storage but this generally occurs slowly enough to allow end use application beforehand.
    [0051] For polymerizing the mononers of the invention, conventional techniques can be used. For instance, the monomers can be heated, either pure or in admixture with other mononers, at teπperatures where polymerizaticn will occur thermally. Temperatures in the ränge of 150°C and over are ordinärily suitable.
    [0052] Otherwise, free radical promoters or irradiation in the presence of photoinitiators can be used when polymerization is to be carried out at lewer tenperature, e.g. roem tenperature. Conditions for photopolymerization are also conventicnal and can be found in the following references: U.V. Curinq Science K Technology, Editor: Technology Marketing Corp. (1978) Stamford, Conn.06902, USA. For instance, a coating of protective polymer according to the inventicn can be applied on organic glasses made, for example, of transparent resins such as polycarbonate or polymethacrylate. For this, the monomers of the invention (either pure or in admixture with other mononers) and a photoinitiator are applied as a thin layer over the surface of said organic glass and the whole is subjected to irradiation for periods ranging from a few seconds to several minutes by means of ultraviolet radiation, e.g. a high pressure mercury lamp, the emission of which is mainly in the ultraviolet wavelengths (300-330 nm) or the Short visible wavelengths. The pie ces of organic glasses thus acquire a very hard, solvent-resistant and transparent protective film enabling them to be used in applicatiens where resistance to solvents, especially chlorinated solvents, and mechanical abuse is a problem, e.g. transparent construetien plates, optical material, etc... The examples below further illustrate the inventicn in roore de- tail.
    [0053] EXPERIMENTAL
    [0054] Example 1
    [0055] Preparation of the diacrylate ester of 1,3-dimethyl-5 ,7-adamantane-diol
    [0056] (Compound (I) , R = CH3; R' = H)
    [0057] a) Oxidaticn of 1,3-dimethyladamantane with chromic anhydride: This reaction was carried out as described in French Patent No. 1.461.287 and gave the corresponding diol in yields of about 85%. b) Esterification of diol (Ila) with acrylyl chloride 9.55 g (48.6 mmole) of 1,3-dimethyl-5,7-adamantane-diol were dissolved in a solution of 14 ml (100 mmole) of triethylamine in 400 ml of anhydrous tetrahydrofurane (THF) at 40°C. The solution was kept between 40 and 50°C while adding, dropwise with stirring, 8.1 ml (100 mmole) of acrylyl chloride. The addition lasted 45 min. Stirring was continued for 1 hr afterwards and the insoluble triethylamine hydrochloride was removed by filtration. The solid was dried and weighted, the result corresponding practically to the expected theoretical weight and shcwing that the reaction is about quantitative. The filtrate was concentrated under reduced pressure (12 Torr; below 50°C) until 14,8 g of the crude diacrylate was obtained. The crυde product was easily purified by column chronatography on Al2O3 using hexane or Chloroform as eluent. MP of the pure diacrylate was 45,5- 46°C. The NMR spectrum was taken in CDCl3, using TMS as the internal Standard. The chemical shifts are given in ppm

    (s,8H) : adamantane-CH2- ; 2.48 (s ,2H) : adamantane-CH2- ; 5.65 (m (complex), 6H) : -CO-CH=CH2. Example 2
    [0058] Preparation of diacrylate and dimethacrylate ester of 1,3-dimethyl-5,7-bis-(2-hydroxymethyl) adamantane a) Dibranination of dimethyladamantane
    [0059] This dibroninaticn to 1,3-dimethyl-5,7-dibronoadamantane can be carried out according to known techniques using bronine in the presence of Lewis acids such as AlBr3, and BBr3. The present preparaticn was performed according to E.R. TALATY et al, J. Chem, Soc. (C) 1968, 1902. Thus, 328 g of dimethyladamantane (2 mole) were treated with 1.04 1 of anhydrous bronine in the presence of 50 ml BBr3 and 2.2 g of AlBr3 to give 510 g of the desired product (80% yield) .
    [0060] b) Conversion of the dibromo-dimethyl-adamantane (III) or the corresponding dihydroxy-compound (Ila) to the corresponding dicarboxylic acid (lila). This reacticn was carried out according to the directions given in French Patent No 1.476.992. Thus, treating 165 g (0.51 mole) of 1,3-dimethyl-5,7-dibronoadamantane in 1.8 1 of sulfuric acid (103% H2SO4 equiv.) with 190 ml of HCOOH at 10°C gave, after hydrolysis, 121.3 g of the desired dicarboxylic acid (yield 94%) .
    [0061] Similar results were obtained when using, as the starting material, the corresponding 1,3-dimethyl-5,7-adamantane-diol.
    [0062] c) Esterification of the dimethyl-adamantane-dicarboxylic acid (lila)
    [0063] Esterification of the above compound can be performed according to conventicnal techniques, e.g. by the direct interaction with a lower alcohol such as MeOH, EtOH in the presence of catalysts such as B2SO4, BF3, tosylic acid and the like. Another reute is the conversion of the diacid into its dichloride followed by reaction of the latter with the lewer alcchols. Thus, 31 g (0.12 mole) of 1,3-dimethyladamantane-5,7-dicarboxylic acid was boiled for 4 hours under reflux with 160 ml SOCl2. The excess of thicnyl chloride was removed under reduced pressure and the residue was dissolved into 100 ml
    [0064] CCl4 to which was added an excess of absolute ethanol. The solvent and excess alcchol were stripped off and the crude diester was distilled under reduced pressure (B.P./0.8 Torr: 135 - 139°C); yield
    [0065] 34,9 g (92%) NMR spectrum (CCl4; TMS; ppmδ). 0.92 (s,6H): -C-CH3 ; 1.17 (s,2H) : adamantane-CH2-;
    [0066] 1.23 (t,6H, J = 7.2 eps) : -CH3 (of ethoxy);
    [0067] 1.48 (s , 8H) adamantane-CH2 ;
    [0068] 1.82 (s , 2H) : adamantane-CH2 ;
    [0069] 4.10 (g,4H, J = 7.2 eps) : -CH2- (of ethoxy) .
    [0070] d) Reducticn of the dimethyl-adamantane dicarboxylate with LiAlH4
    [0071] Six g of lithium-aluminum hydride (0.158 mole) was stirred with 200 ml of absolute ether and to this was added dropwise 24.15 g (0.078 mole) of diethyl 1,3-dimethyladamantane-5,7-dicarboxylate in 50 ml of absolute ether at a rate such as to maintain gentle refluxing of the solvent. Refluxing was centinued for 2 hrs and the excess LiAlH4 was decomposed with moist AcOEt. The reaction mixture was aeidified with 20% H2SO4 which gave, by crystallizaticn, 15.3 g of 1,3-dimethyl-5,7-bis(hydroxymethyl)-adamantane (Ilb) which was collected by filtratien. Another 1.8 g crop was obtained fron the filträte after separating the water phase and evaporating the organic layer. Yield was 17.1 g (97%) . MP was 158-161 °C. Eecrystallization from ethyl acetate afforded a product MP 160-162°C. NMR spectrum (DMSO-d6 + CDCl3, TMS, ppm

    1.10 (s,12H) : adamantane-CH2-;
    [0072] 3.16 (d,4H, J = 6 cps) : -CH2-OH; 3,93 (t,2H, J = 6 eps) : -CH2-OH.
    [0073] e) Esterificaticn of the 1,3-dimethyl-5 ,7-bis(hydroxymethyl) -adamantane (Ilb) into the corresponding diacrylic and dimethacrylic esters (I) , R = CH3; R' = H, CH3; A = -CH2-.
    [0074] 1. Reacticn with acrylyl chloride.
    [0075] To a solution of 11.15 g of 1,3-dimethyi-5 ,7-bis(hydroxymethyl)-adamantane (49.7 mmole) in 280 ml of benzene and 16.7 ml (120 mmole) of triethylamine was added, dropwise at reem tenperature, 8.84 ml (109 mmole) of acrylyl chloride over a 45 min period. The tenperature rose to abeut 40 °C and triethylamine hydrochloride separated. The Suspension was further stirred for 1 hr at 40 °C after which it was filtered and the solid was washed with benzene. The combined washings and filtrate were extracted with, successively, water, saturated aqueous NaHCO3, 5% HCl and finally water. The benzene solution was dried on anhydrous Na2SO4 and cencentrated below 40°C, leaving a viscous colorless residue that crystallized on standing in the cold. Yield 13.2 g (80%) of diacrylate (I) , R = CH3; R' = H; A = -CH2-. The product was crystallized fron EtOH-H2O giving colorless crystals having a MP 49-50.5 °C.
    [0076] NMR spectrum (CCl4, TMS, ppm
    )
    [0077] 1.16 (s,12H) : adamantane-CH2-;
    [0078] 3.80 (s,4H) : -CH2O-;
    [0079] 5.6-6.7 (complex m, 6H) : -CO-CH=CH2
    [0080] 2. Reaction with methacrylyl-chloride
    [0081] Methacryl chloride (12.3 ml, 127.3 mmole) was added dropwise at 40°C to a solution of 12.97 g (57.8 mmole) of 1,3-dimethyl-5 ,7-bis (hydroxy ethyl) adamantane in 315 ml of dry benzene containing 17.7 ml (127.3 mmole) of Et3 . After the addition was complete, stirring was continued for 5 hrs at 60º °C and, thereafter, the precipitated hydro chloride was filtered off and washed with benzene. The. combined filtrate and washings were scrubbed as described abvove in the case of the diacrylate and, after drying the organic phase and evaporating the solvent, 18.7 g (90%) of the dimethycrylate (I) , R = R' = CH3; A = -CH2-, was recovered as a viscous residue. This. was further purified by column chromatography on Al2O3 using CHCl3 as eluent. Analysis showed that it was reasonably pure but it dit not crystallize.
    [0082] NMR spectrum (CDCl3, TMS,

    [0083] 1,18 (s,12H) : adamantane-CH2-;
    [0084] 3.85 (s,4H): -CH2-O-;
    [0085]
    [0086] Example 3
    [0087] Preparation of diacrylate and dimethacrylate esters of 1,3-dimethyl-5,7-bis(2-hydroxyethyl)adamantane (I) , R = CH3; R' = H, CH3; A = -CH2-CH2-
    [0088] a) 1,3-dim8thyl-5,7-adamantanediacetic-acid diethylester l,3-dimethyl-5,7-adamantanediacetic acid (IV) was prepared by kncwn techniques (K. BOTT, Chem.Ber. ,101, 564(1968). Esterification can be achieved by the same conventional techniques mentioned under Example 2C. Thus, 28.7 g of 1,3-dimethyl-5,7-adamantane diacetic aeid (0.10 mole) was boiled with an excess of absolute ethanol and 1.2 ml ccncentrated sulfuric acid for 12 hrs under reflux to yield 31.7 g of diethyl ester (91%) BP 0.45 Torr 140 - 145°C.
    [0089] NMR Spectrum- (CCl4 solution, TMS as infernal Standard,
    0.85 (s,6H) : -C-CH3 1.20 (s,12H): adamantane-CH2- 1-20 (t,6H, J = 7 Cps) -O-CH2-CH3
    4.05 (q,4H, J = 7 cps) : -O-CH2-CH3
    [0090] b) 1,3-dimethyl-5,7-bis(2-hydroxyethyl)adamantane (IIc) The diol (IIc) was obtained by reducing the 1,3-dimethyl-5,7-a damantanediacetic acid diethylester with Lithium aluminum hydride: To 7.5 g LiAlH4 (197.6 mmole) in 250 ml dry ether was added 30.2 g of diester (89.8 mmole) dissolved in 50 ml ether at such a rate that a gentle refluxing of the solvent is maintained. Refluxing was con tinued for an additional 2 hrs after which time the excess LiAlH4 was deccnposed with ethyl acetate and water. The reaction mixture was acidified with H2SO4 20% and filtered, leaving 6.15 g of diol IIc. A further 13.3 g of diol was obtained fron the filtrate after separating and evaporating the organic layer. Yield 19.45 g (86%) of diol (IIc) MP: 133 - 135°C (frcm ether) . NMR Spectrum (DMSO-d6 solution, TMS as infernal Standard,
    1.04 (s,12H) : adamantane-CH2- 1.27 (t,4H, J = 7.5 cps) : -CH2-CH2-O- 3.43 (t,4H, J = 7.5 cps) : -CH2-CH2-O-
    [0091] c) Esterificatien of 1,3-dimethyl-5,7-bis(2-hydroχyethyl)adamantane into the corresponding diacrylic and dimethacrylic esters,
    [0092] (I) , R = CH3, R' = H, CH3; A = -CH2-CH2-
    [0093] 1. Reaction with acrylyl chloride
    [0094] To 5 g of 1,3-dimethyl-5,7-bis-(2-hydroxyethyl)adamantane (19.8 mmole) in 120 ml dry tetrahydrofurane (THF) containing 6.08 ml triethylamine (43.6 mmole) was added 3.52 ml acrylyl chloride (43.6 mmo le) during a 25 min period, while maintaining the tenperature at 45 - 50°C. Stirring was centinued for 5 hrs at 60°C. The precipitated triethylamine hydrochloride was filtered off and washed with THF. The filtrate and washings were evaporated to dryness and the residue re dissolved in benzene. The benzene was successively extracted with water, saturated bicarbonate solution and water and finally dried. Evaporation of the solvent provided 6.7 g (94%) of diacrylate (I), R = CH3; R' = H A = -CH2-CH2-. Further purification was achieved by column chromatography cn Al2O3 using Chloroform as the eluent. TMS as infernal Standard,

    1.11 (s,12H) : adamantane-CH2- 1.45 (t,4H, J = 7.5 cps) : -CH2-CH2-O- -
    [0095] 2.Reaction with methacrylyl chloride
    [0096] The same condition as for the reaction with acrylyl chloride were found suitable, except for using instead 4.2 ml methacrylyl chloride (43.6 mmole). The yield was 7.3 g (95%) of dimethacrylate (I), R = R' = CH3, A = -CH2-CH2-. Further purification was achieved by column chromatography on Al2O3 using Chloroform as the elue
    [0097] NMR Spectrum (CCl4 solution, TMS as infernal Standard,
    0.83 (s,6H): -C-CH3 1.13 (s,12H) : adamantane-CH2-- -
    [0098]
    [0099] Example 4
    [0100] Preparaticn of diacrylate and dimethacrylate esters of 1,3-bis (2-hydroxyethyl)adamantane
    [0101] (I) , R = H; R' = H, CH3; A = -CH2-CH2-
    [0102] a) 1,3-adamantane-diacetic acid diethylester
    [0103] Esterification of coπmercially available 1,3-adamantane diacetic acid (Aldrich Chemical Co,Inc.) can be achieved by conventional techniques as mentioned heretofore. In this case, the acid chloride method was used. Thus, 20.8 g of 1,3-adamantane-diacetic acid (82.4 mmole) was boiled with 100 ml thionylchloride under reflux for 4 hrs. The excess thionylchloride was then evaporated off and the resulting crude acid chloride was dissolved in 65 ml carbon tetrachloride and subseσuently treated with an excess absolute ethanol. The solvent and excess alcohol were stripped off and the crude diester was distilled under vacum.
    [0104] BP 0.1 Torr = 149°-150°C. Yield 22.6 g (89%).
    [0105] NMR spectrum (CCl4 solution, TMS as infernal Standard,
    [0106] 1.17 (t,6H, J = 7cps) : -OCH2-CH3
    [0107] 1.33 - 1,63: (complex m,12H) adamantane-CH2-

    [0108] 4.05 (q,4H, J = 7cps) : -O-CH2-CH3
    [0109] b) 1,3-bis-(2-hydroxyethyl)adamantane This diol can be obtained by reducing the 1,3-adamantane-diacetic acid diethylester with lithium aluminium hydride:
    [0110] To 5.65 g LiAlH4 (148.9 mmole) in 185 ml dry ether was added 22.5 g of the diester (73 mmole) in 40 ml ether at such a rate as to maintain the solvent under gentle reflux. Refluxing was continued for a further 2.5 hrs and, thereafter, the excess LiAlH4 was decomposed with ethylacetate and water. The reaction mixture was acidified with 20% H2SO4 and the organic layer was separated and washed to neutrality with water. Crystals of the pure diol then separated. Yield 12.6 g (77%) NMR Spectrum (DMSO-d6 solution, TMS as infernal Standard,

    [0111] 1.95 (m,2H) : adamantane -C-H 3.48 (t,4H, J = 7.5 cps): -CH2-CH2-OH 4.08 (s,2H)
    [0112] c) Esterifieaticn of 1,3-bis(2-hydroxyethyl)adamantane to give the corresponding diacrylic and dimethacrylic esters (I), R = H, R' = H,CH3; A = -CH2-CH2- 1. Reacticn with acrylyl chloride To 5 g (22.3 mmoles) of 1,3-bis(2-hydroxyethyl)adamantane in 120 ml of dry benzene containing 6.83 ml of triethylamine (49.1 mmoles) was added, at 45°C, 3.97 ml acrylyl chloride (49.1 mmoles) . Stirring was continued for 5 hrs at 60°C, and the precipitated triethylamine hydrochloride was filtered off and washed with benzene. The combined filtrate and washings were extracted with water, saturated bicarbonate solution and water and finally dried. Evaporation of the solvent yielded 7.0 g (95%) of diacrylate
    [0113] (I) , R = R' = H; A = -CH2-CH2-. Further purification was achieved by column chromatography on A12O3.using Chloroform as the el
    uent. NMR Spectrum (CCl4 solution, TMS as infernal Standard, .
    [0114]
    4.22 (t,4H, J = 7.5 eps) : -CH2-CH2-O-
    [0115] 5.6 - 6.6 (cαiplex m, 6H) : -CO-CH=CH2
    [0116] 2. Reaction with methacrylyl chloride
    [0117] The same conditions were used as with the previous case but 4.74 ml (49.1 mmoles) of methacrylyl chloride was used instead of the acrylyl chloride. The yield was 7.78 g (97%) of dimethacrylate (I), R = H; R' = CH3; A = -CH2-CH2- Further purification was carcied out by column chromatography (A12O3; CHCl3) .
    [0118] NMR Spectrum (CDCl3, TMS as internal Standard, .
    [0119]
    [0120] Example 5 Preparation of diacrylate and dimethacrylate esters of 1,3-dimethyl-5,7-bis(p-hydroxyphenyl)adamantane
    a) 1,3-dimethyl-5,7-bis(p-hvdroxyphenyl)adamantane (Ild)
    [0121] Adamantane bisphenols can be readily made available from the corresponding dibroncderivatives and phenol according to US 3,594,427. Thus, 112 g of 1,3-dimethyl-5,7-dibronoadamantane (III) (0.35 m) (see Exaπple 2a) and 900 g of phenol were heated together at 170°C for 6 hrs. After termination of the evolution of HBr, the mixture was heated to 220 °C for a further 2 hrs period and the excess phenol was distilled off . The reaction mixture was poured into warm water and the white precipitate was filtered, washed with warm water and dried at 80°C under vacuum. Yield 117.8 g (97%) . The product was recrystallyzed fron toluene. MP: 222° - 224°C.
    [0122] b) Esterificaticn of the 1,3-dimethyl-5,7-bis(p-hydroxyphenyl)adamantane into the corresponding diacrylic and dimethacrylic esters
    [0123] 1. Reaction with acrylyl chloride
    [0124] To 5 g of 1,3-dimethy1-5,7-bis(p-hydroxyphenyl)adamantane (14.3 nsnoles) in 120 ml dry tetrahydrofurane containing 4.4 ml triethylamine (31.6 mmoles) was added 2.55 ml acrylyl chloride (31.6 mmoles) during 25 min, while maintaining a reaction tenperature of 45-50°C. Stirring was centinued for 4 hrs at 60°C and the solvent was evaporated under vacuum. The crude reaction product ( 7 g) was crystallyzed fron ethyl acetate. The yield was 5.2 g (80%) of pure diacrylate (I) , R = CH3; R' = H; A = p-Ph; MP: 145-147°C. NMR Spectrum
    1.23 (s,2H) : adamantane-CH2- 1.55 (s,8H) : adamantane-CH2- 1.85 (s ,2H) : adamantane-CH2-

    [0125]
    2. Reacticn with methacrylyl chloride
    [0126] This was performed as above but using, instead of the acrylyl chloride, 3.04 ml of methacrylyl chloride (31.6 mmole). The yield of dimethacrylate was 5.6 g (81%) MP: 159.5
    - 161°C (fron ethyl acetate). NMR Spectrum
    1.23 (s,2H) : adamantane-CH2- 1.57 (s,8H) : adamantane-CH2- 1.87 (s,2H) : adamantane-CH2-
    [0127]
    While p-phenylene was used in this example, it is expected that alkyl derivatives of phenylene could also be so utilized.
    [0128] Example 6
    [0129] Thermal and free radical polymerization of some monomers of LIST I a) Thermal polymerization of the diacrylates.
    [0130] The diacrylates (I) were subjeeted to heating neat at tenperature ranging fron 150 - 200°C until they had completely hardened. Required heating times were extremely variable, ranging from several minutes to several hours.
    [0131] The compounds, identified by their substituants, the polymeri zation conditions and the results on hardness are summarized in Ta ble 1 below.
    [0132]
    [0133] The diacrylates and dimethacrylates (I) were free radical polymerized using small amounts of standard initiator catalysts and teπperatures of 20 to 150°C depending on the kind of initiator. In this manner, very hard, colorless, transparent, highly cross-link ed resins were obtained which were infusible and found insoluble in all solvents tried. The solvents tried were 1,1,1-trichlorcethane; Chloroform; 1,2-dichloroethane; benzene; toulene; "rylene; acetone; methyl ethyl ketone; and butyl acetate. Examples are summarized be low using lauroyl peroxide as the initiator. Compounds (I) are iden tified by their substituents R and R'.
    [0134]
    Example 7
    [0135] Photopolymerization of some monomers of LIST I
    [0136] The mononers of formula (I) in liquid form, either neat (melt ed) or dissolved in other liquid olefinic compounds (e.g. acrylic acid, acrylates or acrylamides) were mixed with small amounts of Standard photoinitiators (e.g. aromatic ketones) and spread with conventional means (including a doktor knife, painting, spraying and dipping) as thin layers (e.g. 1 to 10 /u) over transparent plates of organic glasses (e.g. polymethacrylates (LUCITE) or polycarbonates (MAKROLCN, Bayer). Then, the coated plates were photopolymerized at varrious temperatures for periods ranging from a few seconds to about a minute using a ultraviolet light source. The organic glasses thus coated were totally inert when immersed into chlorinated solvents (e.g. CHCl3, trichlorethylene, o-dichlorobenzene, etc.) whereas non coated controls will either swell or dissolve under the same conditions. Coatings obtained fron ccnventioial monomers such as hexanediol diacrylate, trimethylol-proparie triacrylate or pentaerythritol tri- and tetra-acrylates were much less effective in the protection of organic glasses toward outside solvents. Further, the coatings made according to the inventicn were generally very hard and effectively protected the organic glasses fron scratches resulting from accidental ccntacts with hard objects. Also their adhesive power was excellent and they could not be removed fron such Substrates by usual mechanical means.
    [0137] Table 3, below, summarizes sone results obtained from various compounds (I) identified again by the nature of their substituents R, R' and A which were photopolymerized in the presence of 1% of benzophenone as films about 5.8/u thick deposited on Substrates of either aluminum, polyester (MYLAR) , polymethacrylate (LUCITE) or polycarbonate (MACROLON) and placed for 1 min at 25 an fron a PHILIPS HOK 1KW ultraviolet lamp, at the temperatures indicated in the table. Mixtures cf monomers (I) and conventional monomers as well as controls obtained fron ccnventicnal monomers and two of the bare Substrate are also included in the table.

    [0138] Although the examples have been limited to methylene and ethy lene, the propylene and butylene are additional honologs that one skilled in the art would expect to form similar compounds with but only a slight loss in hardness and strength properties.
    权利要求:
    ClaimsC L A I M S
    1. A compound having the formula
    wherein R is a radical selected fron the group consisting of hydrogen or methyl; R' is a radical selected from the group consisting of hydrogen or meiihyl; and A is either a sigma ( ) bond; or a radical satisfying the formula (CH2)n where n is an integer of fron 1 through 4; or phenylene; or an alkyl derivative of phenylene.
    2. Compounds according to claim 1, where R = H or CH3 R' = H or CH3 A is a sigma {*£) bond
    3. Compounds according to claim 1, where R = H or CH3 R' =H or CE3 A = -CH2 or -CH2-CH2-
    4. A composite material which will withstand more than 24 hours immersion in chlorinated solvents without significant damage, comprising:
    (a) a clear substrate of organic glass; and
    (b) a very fine coating of cross-linked polymers resulting from the polymerizaticn of monomers described in Claims 1, 2, or 3.
    5. A composite material as described in claim 4 where the thickness of the coating is in the range of 2 to 8 microns.
    6. Cross-linked polymers obtained by the polymerization of the compounds of claim 1, 2, or 3, or the copolymerization of mixtures thereof.
    7. Cross-linked resins obtained by copolymerizing the compounds of claim 1, 2, or 3 in admixture with other copolymerizahle acrylic mononers.
    8. The cross-linked resins of claim 7, as obtained by thermal, free-radical, or photo-initialed polymerization methods.
    9. The cross-linked resins of claim 7 having outstanding thermal resistance, up to the ränge of 400-450°C.
    10. The cross-linked resins of claim 7 having knoop hardness exceeding 25.
    11. Conpounds of the formula
    ftherein R and R' are hydrogen or methyl and A is a bond, a methylene, an ethylene or a phenylene group.
    12. Compounds according to claim 11, selected fron the group consisting of the following diesters:
    Adamantane-diol acrylate and methacrylate; dimethyl-adamantane-diol acrylate and methacrylate; adamantane-dimethylol acrylate and methacrylate; dimethyl-adamantane-dimethylol acrylate and methacrylate; di-(hydroxyethyl)-adamantane acrylate and methacrylate; dimethyl-di (hydroxyethyl) -adamantane acrylate and methacrylate; di-(hydroxyphenyl)-adamantane acrylate and methacrylate; dimethyl-di-(hydroxyphenyl)-adamantane acrylate and methacrylate.
    13. Cross-linked polymers obtained by the polymerization of the compounds of claim 11 or 12 or the copolymerization of mixtures thereof.
    14. Cross-linked resins obtained by copolymerizing the compounds of claim 12 in admixture with other copolymerizable acrylic monomers.
    15. The cross-linked resins of claim 14, as obtained by thermal-, radical- or photo-initiated polymerization methods.
    16. The cross-linked resins of claim 14 having outstanding ther mal resistance, i.e. up to 400 - 450°C.
    17. The cross-linked resins of claim 14 having KNOOP hardness better than 25.
    18. Clear substrates made of organic glasses coated with a 2 to 8 μm layer of cross-linked polymer resulting from the polymerizaticn of monomers according to claim 1, which will withstand more than 24 hrs immersion in chlorimated solvents without significant damage.
    19. The compound of claim 1 wherein A is a sigma bond.
    20. The compound of claim 1 wherein A is -CH2- or -CH2-CH2-.
    21. The compound of claim 1 wherein A is a phenylene group.
    22. The compound of claim 19, 20, or 21 wherein R and R' both are hydrogen.
    23. The compound of claim 19, 20, or 21 wherein R and R' both are methyl groups.
    24. The coipound of claim 19, 20 or 21 wherein R is hydrogen and R' is a methyl group.
    25. The compound of claim 19, 20 or 21 wherein R is a methyl group and R' is hydrogen.
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    同族专利:
    公开号 | 公开日
    DE3165043D1|1984-08-30|
    EP0053621A1|1982-06-16|
    JPS57500785A|1982-05-06|
    JPH0153663B2|1989-11-15|
    EP0053621B1|1984-07-25|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    法律状态:
    1981-12-24| AK| Designated states|Designated state(s): JP |
    1981-12-24| AL| Designated countries for regional patents|Designated state(s): AT CH DE FR GB LU NL SE |
    1982-02-05| WWE| Wipo information: entry into national phase|Ref document number: 1981901541 Country of ref document: EP |
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    优先权:
    申请号 | 申请日 | 专利标题
    US15850480A| true| 1980-06-11|1980-06-11||
    US158504||1980-06-11||DE8181901541T| DE3165043D1|1980-06-11|1981-06-09|Unsaturated esters of adamantane containing diols and thermo-resistant cross-linked polymers therefrom|
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