• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    An apparatus for manipulating a medical device is formed of at least three coupled movable blades which are disposed about a reference circle to form an aperture whose size may be varied. The aperture capable of being sized to contain a medical device. Each blade is in communication with an actuation device which is capable of moving the blade to alter the size of the aperture. Each blade includes a single radial point which a) lies on the circumference of the reference circle prior to movement of the blade, and b) may be moved only along a radius of the reference circle on movement of the blade.
    公开号:US20010001890A1
    申请号:US09/401,218
    申请日:1999-09-22
    公开日:2001-05-31
    发明作者:Michael Austin
    申请人:Scimed Life Systems Inc；
    IPC主号:A61M25-1029
    专利说明:
    [0001] This invention relates to an apparatus and a method for reducing in size a medical device such as a stent, stent-graft, graft, or vena cava filter. The apparatus may be used in particular for fastening a medical device onto a catheter. [0001]
    [0002] Medical devices such as stents, stent-grafts, grafts, or vena cava filters and catheters for their delivery are utilized in a number of medical procedures and situations, and as such their structure and function are well known. [0002]
    [0003] A stent, for example, is a generally cylindrical prosthesis introduced via a catheter into a lumen of a body vessel in a configuration having a generally reduced diameter and then expanded to the diameter of the vessel. In its expanded configuration, the stent supports and reinforces the vessel walls while maintaining the vessel in an open, unobstructed condition. [0003]
    [0004] Stents are typically inflation expandable or self-expanding. Self expanding stents which are constrained by a sheath or other restraining means, must be provided in a reduced diameter. [0004]
    [0005] An example of a stent described in PCT Application No. 960 3092 A1, published Feb. 8, 1996. [0005]
    [0006] In advancing a stent through a body vessel to the deployment site, the stent must be able to securely maintain its axial position on the delivery catheter, without translocating proximally or distally, and especially without becoming separated from the catheter. Stents that are not properly secured or retained to the catheter may slip and either be lost or be deployed in the wrong location. The stent must be crimped in such a way as to minimize or prevent altogether distortion of the stent and to thereby prevent abrasion and/or reduce trauma of the vessel walls. [0006]
    [0007] In the past, this crimping or size reduction has been done by hand often resulting in the application of undesired uneven forces to the stent. Such a stent must either be discarded or re-crimped. Stents which have been crimped or otherwise reduced in size multiple times can suffer from fatigue and may be scored or otherwise marked which can cause thrombosis. A poorly crimped stent can also damage the underlying balloon. [0007]
    [0008] Recently, stent crimping devices halve been disclosed in U.S. Pat. No. 5,546,646 to Williams et al, U.S. Pat. No. 5,183,085 to Timmermans et al., U.S. Pat. No. 5,626,604 to Cottone, Jr., U.S. Pat. No. 5,725,519, U.S. Pat. No. 5,810,873 to Morales, WO 97/20593 and WO 98/19633. [0008]
    [0009] A cam actuated stent crimper, shown in FIG. 1, employs a plurality of arc-shaped or curved slots with semi-circular ends, disposed such that each slot or cam engages a cam follower bearing [0009] 22. The arc-shaped or curved surfaces of the slots are inclined to be non-concentric relative to the axis of rotation 26, and therefore rotation of the cam plate 28 transmits equal radial displacements to the cam follower bearings 22, to simultaneously actuate a like number of linear bearings 24, which have their corresponding linear tracks or rails mounted on a fixed plate. As shown in FIG. 1 the cam plate rotary drive 29 comprises a pneumatic cylinder mounted on a pivot or trunnion, arranged with the cylinder rod connected rotatably to a short arm fixed rigidly to the cam plate. Accordingly, linear motion produced by the pneumatic cylinder translates into controllable arcs of motion of the circular cam plate, which has a projecting V-shaped profile on its outer edge in rolling engagement with three equally spaced rollers with mating inverse V-shaped profiles to provide precise rotatable support to the cam plate. Depending on the direction of rotation, the linear slides which each carry a radially disposed crimping blade, are either moved inwards to apply a crimping force to the stent, or outwards to release the stent. Also when crimping, depending on the degree of rotation of the cam plate, a specific radial crimping displacement may be obtained to match the diametral reduction required for any particular stent.
    [0010] All US patents and applications and all other published documents mentioned anywhere in this application are incorporated herein by reference in their entirety. [0010] BRIEF SUMMARY OF THE INVENTION
    [0011] It would be desirable to produce at device capable of crimping a stent uniformly while minimizing the distortion of and scoring and marking of the stent due to the crimping. The present invention is directed to that end. [0011]
    [0012] The present invention is particularly concerned with the crimping and otherwise reducing in size of inflation expandable stents, self-expanding stents and other expandable medical devices. For the purpose of this disclosure, it is understood that the term ‘stent’ includes stents, stent-grafts, grafts and vena cava filters. It is also understood that the term ‘crimping’ refers to a reduction in size or profile of a stent. [0012]
    [0013] In the description that follows it is understood that the invention contemplates crimping a medical device either directly to a catheter tube or to a catheter balloon which is disposed about a catheter tube. When reference is made to crimping a medical device to a catheter, a balloon may be situated between the medical device and the catheter tube or the medical device may be crimped to a region of a catheter tube directly. The invention also contemplates crimping a stent in the absence of a catheter to reduce the stent in size. [0013]
    [0014] The present invention is directed, in one embodiment, to an apparatus for reducing a medical device in size. Desirably, the medical device is a stent, a stent-graft, a graft or a vena cava filter, whether self-expandable, balloon expandable or otherwise expandable, although the inventive apparatus may also be employed with any other suitable, generally tubular medical device which must be reduced in size. [0014]
    [0015] The inventive apparatus comprises at least three coupled movable blades disposed about a reference circle to form an aperture whose size may be varied. Each blade is in communication with an actuation device which is capable of moving the blade to alter the size of the aperture. Each blade includes a single radial point on the surface of the blade which a) lies on the circumference of the reference circle prior to movement of the blade, and b) may be moved only along a radius of the reference circle on movement of the blade. [0015]
    [0016] The apparatus further includes an actuation device which comprises a cam and a plurality of linear slide devices. Each linear slide device is in communication with a blade. Each of the linear slide devices is also in mechanical communication with the cam. Rotation of the cam results in linear translation of the slide device and blade, such that the slide device moves along an axis parallel to the radius on which the radial point of the blade lies or along the radius itself. [0016]
    [0017] The invention is also directed to an apparatus similar to that described above, with blades disposed about a reference tube to form a tubular aperture whose size may be varied. Each blade is in communication with an actuation device which is capable of moving the blade to alter the size of the tubular aperture. Each blade includes a single line which a) lies on the surface of the reference tube prior to movement of the blade, and b) may be moved only along a radial plane of the reference tube on movement of the blade. [0017]
    [0018] The inventive apparatus finds particular utility in crimping a medical device such as those mentioned above to a catheter or to a balloon disposed about a catheter. [0018]
    [0019] The inventive apparatus also finds utility in reducing the diameter of a medical device such as those mentioned above prior to crimping. [0019]
    [0020] The invention is also directed to a method of manipulating a medical device which comprises the steps of providing the medical device and providing at least three blades capable of applying a radial inward force. The blades are disposed about a reference circle to form a shrinkable aperture. A medical device such as a stent is placed into the shrinkable aperture and the blades simultaneously moved inward to apply a radial inward force to the medical device. The blades are constructed and arranged such that each blade has a single point which a) lies on the circumference of the reference circle prior to movement of the blade, and b) is moved along a radius of the reference circle on movement of the blade. [0020]
    [0021] The inventive apparatus may also be used as a variable size balloon mold. To that end, the invention is further directed to a method of molding a medical balloon. In the practice of the method, a balloon preform prepared through any suitable technique known in the art is provided. The preform is placed in an apparatus which has a shrinkable tubular aperture formed by at least three movable blades disposed about a reference tube. The blades are constructed and arranged such that each blade has a single line which a) lies on the surface of the reference tube prior to movement of the blade, and b) is moved along a radial plane of the reference tube on movement of the blade. The aperture may be set to a predetermined size prior to placement of the preform therein or after placement of the preform therein. An inflation fluid is supplied to the balloon preform to expand the balloon preform until it contacts the blades. The preform may optionally be heated prior to, during or after the blowing step. The thus formed balloon is then pressure relieved and removed from the apparatus. [0021] BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWING(S)
    [0022] FIG. 1 shows a perspective view of a stent crimper; [0022]
    [0023] FIG. 2[0023] a is a schematic front view of an embodiment of the inventive apparatus;
    [0024] FIG. 2[0024] b is a schematic front view of the embodiment of FIG. 2a after the stent has been reduced in size;
    [0025] FIGS. 3[0025] a and 3 b are schematics of blades;
    [0026] FIG. 3[0026] c is a partial schematic front view of an embodiment of the inventive apparatus employing the curved blades of FIG. 3b;
    [0027] FIG. 4[0027] a is a partial front view of an embodiment of the inventive apparatus;
    [0028] FIG. 4[0028] b is a partial front view of an embodiment of the inventive apparatus;
    [0029] FIG. 4[0029] c shows a side view of the embodiment of FIG. 4b taken along lines 4 c-4 c;
    [0030] FIG. 5[0030] a shows a partial front view of another embodiment of the inventive apparatus;
    [0031] FIG. 5[0031] b shows a link connected to a blade;
    [0032] FIG. 6 is a schematic, perspective view of an embodiment of the inventive apparatus; [0032]
    [0033] FIG. 7 shows a partial view of the embodiment of FIG. 6; [0033]
    [0034] FIGS. 8[0034] a and 8 b are partial side elevational views of an embodiment of the inventive apparatus taken along a radial plane during the size reduction process;
    [0035] FIG. 8[0035] c is a partial side elevational view of an embodiment of the inventive apparatus taken along a radial plane following crimping of a stent to a catheter;
    [0036] FIG. 9 is a diagrammatic side elevational view of an embodiment of the inventive apparatus; [0036]
    [0037] FIG. 10 is a partial side elevational view of an embodiment of the inventive apparatus taken along a radial plane of an embodiment of the invention consisting of three individual apparatuses arranged sequentially; [0037]
    [0038] FIG. 11 is a schematic showing a stent being reduced in size and loaded into a sheath; [0038]
    [0039] FIG. 12 is a partial side elevational view of an embodiment of the inventive apparatus taken along a radial plane showing a balloon that has been molded with the inventive device; and [0039]
    [0040] FIG. 13 is a partial side elevational view taken along a radial plane showing a stepped balloon that has been molded with the inventive device. [0040] DETAILED DESCRIPTION OF THE INVENTION
    [0041] While this invention may be embodied in many different forms, there are described in detail herein specific preferred embodiments of the invention. This description is an exemplification of the principles of the invention and is not intended to limit the invention to the particular embodiments illustrated. [0041]
    [0042] As shown generally at [0042] 100 in FIGS. 2a and 2 b, the inventive apparatus comprises eight coupled blades 106 disposed about a reference circle 114 to form an aperture 118 whose size may be varied. The apparatus may comprise as few as three blades and as many as sixteen or more blades. Desirably, the apparatus will have four or more blades and more desirably, eight or more blades. The maximum number of blades is limited only by how many blades can physically be coupled together under the relevant size constraints. As the number of blades is increased, the profile of the aperture and hence of the medical device following reduction in size, becomes smoother. FIG. 2b shows the apparatus of FIG. 2a after the stent has been reduced in size.
    [0043] Blades [0043] 106 as shown in FIG. 3a have an inner end 108 which is desirably beveled 111 so as to mesh with adjacent blades and an outer end 110 which is displaced from aperture 118. Aperture 118 is polygonal. Blades 106 may also be shaped with a curved end 112, as shown in FIGS. 3b and 3 c so as to form a substantially circular shaped aperture, when the aperture is fully closed.
    [0044] Each blade [0044] 106 includes a single radial point 122 which lies on a radial line 126 of reference circle 114 prior to movement of blade 106 and which may be moved only along the radius 126 of reference circle 114 on movement of blade 106. Desirably, the single radial point 122 will be disposed at the tip of the blade adjacent to beveled end 111.
    [0045] In the embodiment shown in FIG. 4[0045] a, radial point 122 lies at the tip of blade 106. Each blade 106 has a connecting link 130 extending from second end 110. Connecting link 130 ends in mounting means 134, typically a mounting flange adapted for attachment to a linear bearing block, for interfacing with an actuation device, shown generally at 138. Actuation device 138 is capable of simultaneously moving blades 106 to alter the size of aperture 118.
    [0046] Actuation device [0046] 138 includes actuation plate 142 which is coaxial with reference circle 114. Actuation plate 142 has eight equi-spaced radial slots 146. More generally, for every blade there will be a corresponding radial slot on actuation plate 142. Each radial slot 146 overlaps a mounting means 134 for a linear bearing block at the end of a connecting link 130. Each blade 106 is engaged to actuation plate 142 via a cam follower bearing 150 disposed in radial slot 146 and attached to mounting means in slotted end 134.
    [0047] Each bearing [0047] 150 extends from a linear slide 154. Linear slide 154 is mounted on a non-rotating plate 156 (shown in FIG. 8). Linear slide 154 is constructed and arranged to slide along a line 158 which is parallel to the radius 126 on which radial point 122 of blade 106 lies.
    [0048] For the purposes of this disclosure, the term ‘cam follower bearing’ includes cam follower bearings, low friction rollers, roller bearings, needle roller bearings and a slipper block pivot mounted on a bearing and stub shaft. FIG. 4[0048] b is a partial front view of an embodiment in which a slipper block is used. A side view of the embodiment of FIG. 4b taken along lines 4 c-4 c is shown in FIG. 4c. Slipper block 150 resides in slot 146 of actuation plate 142. Slipper block 150 is mounted on stub shaft 151 which extends from connecting link 130. Desirably, bearings 153 will be present between shaft 151 and slipper block 150. Connecting link 130, in turn, is fastened to linear bearing block 212 via fasteners 214. Bearing block 212 is linearly mounted on linear slide which is mounted on fixed plate 156. Linear motion is facilitated by the presence of bearings 216.
    [0049] Cam follower bearing [0049] 150 may be replaced by any other suitable connecting member which can connect the slide and the link.
    [0050] In use, as actuation plate [0050] 142 is rotated in a clockwise direction, the clockwise motion of the actuation plate is translated into linear motion of each of linear slide 154 and blade 106 via bearing 150. Each blade 106 moves outward in a direction parallel to the radius 126 on which the radial point 122 of the blade 106 lies, resulting in the opening of aperture 118. As actuation plate 142 is rotated in a counterclockwise direction, each blade 106 moves inward in a direction parallel to the radius 126 on which the radial point 122 of the blade 106 lies, resulting in the closing of aperture 118. As aperture 118 closes, a radially inward force is applied to a medical device disposed in the aperture. The actuation plate is rotated until the desired size reduction of the aperture and medical device has been achieved. Following the reduction, the actuation plate is rotated in the opposite direction to allow for removal of the medical device from the aperture.
    [0051] The apparatus may be used to reduce the diameter of a suitable medical device such as those disclosed above or may be used to crimp a medical device to a catheter. [0051]
    [0052] Another embodiment of the invention is shown in FIG. 5[0052] a. Each blade 106, as shown in FIG. 5a, has a connecting link 130 extending therefrom. Connecting link 130 is rigidly attached to blade 106. Connecting link 130 ends in an angled end 134 for interfacing with an actuation device, shown generally at 138. Actuation device 138 is capable of simultaneously moving blades 106 to alter the size of aperture 118.
    [0053] Actuation device [0053] 138 includes a rotatable actuation plate 142 which is co-axial with reference circle 114. Rotatable actuation plate includes cam slots 146 which are not concentric with the axis of rotation, arcing inward. Each connecting link 130 is engaged to actuation plate 146 via a cam follower bearing 150 disposed in slot 146 and attached to both angled end 134 of connecting link 130 and to a linear slide 154. Linear slide 154 is mounted on a non-rotating plate similar to that shown in FIG. 8. Linear slide 154 is constructed and arranged to slide along a radial line 158 on which radial point 122 of blade 106 lies.
    [0054] Connecting link [0054] 130 may be bonded adhesively, welded, joined with a fastener or otherwise joined to blade 106. As shown in FIG. 5a, a single screw 131 is used to connect link 130 to blade 106. FIG. 5b shows a connecting link 130 including a right angle portion which is fastened to a blade 106 using two screws 131. Connecting link 130 and blade 106 may optionally be formed of a single piece of material. Regardless of how the connecting member is joined to the blade, no movement of the blade relative to the connecting link is permitted.
    [0055] In use, as actuation plate [0055] 142 is rotated in a clockwise direction, the clockwise motion of the actuation plate is translated into a linear outward motion of each of linear slides 154 and blades 106 via bearings 150 resulting in the opening of aperture 118. The outward motion results from the radially outward arcing of cam slot 146. As actuation plate 142 is rotated in a counterclockwise direction, each blade 106, because of the radially inward arc of cam slots 146, moves inward in a direction parallel to the radius 126 on which the radial point 122 of the blade 106 lies, resulting in the closing of aperture 118. As discussed above, as the aperture is decreased in size, a radial inward force is brought to bear against a medical device disposed in the aperture, thereby reducing the size of the medical device.
    [0056] The embodiment of FIG. 5[0056] a differs from the embodiment of FIG. 4a in that in the embodiment of FIG. 5a, the slide moves along the radial line on which the radial point of the attached blade lies whereas in FIG. 4a the slide moves parallel to the radial line. In both of the embodiments, each of the blades is constrained with two degrees of freedom to satisfy the condition that the movement of the tip be radial in accordance with the invention.
    [0057] In the embodiments of FIGS. 4[0057] a and 5 a, the slots in the actuation plate are constructed and arranged to allow for a sufficient reduction in size of the aperture so that a medical device can be reduced in size to a desired diameter. Those of ordinary skill in the art will recognize other suitable actuation devices that may be used in the practice of this invention.
    [0058] Desirably, in the above embodiments, the blades will be as long as or longer than the medical device disposed within so that the medical device is uniformly reduced in size along its entire length. [0058]
    [0059] This is illustrated in the embodiment of FIGS. 6 and 7 and further in FIGS. 3[0059] a and 3 b in which blades 106 are disposed about a reference tube 160 to form a tubular aperture 162 whose size may be varied. Reference circle 114 is seen to lie along reference tube 160. Each blade 106 is in communication with an actuation device such as that shown in FIGS. 4 or 5. The actuation device is capable of moving blades 106 to alter the size of tubular aperture 162. Each blade 106 includes a single line 166 which a) lies on a radial plane 170 of the reference tube 160 prior to movement of blade 106, and b) may be moved only along a radial plane 170 of reference tube 160 on movement of blade 106. Desirably, reference tube 160 is cylindrical and exceeds the length of the medical device to be reduced in size.
    [0060] Another embodiment of the invention is illustrated in FIGS. 8[0060] a and 8 b. In the embodiment of FIGS. 8a and 8 b, two non-rotating plates 156 are present, one at each end of the apparatus. Each blade 106 is connected at first end 174 to a linear slide 154 a via a connecting link 130 a and at second end 178 to a linear slide 154 b a via a connecting link 130 b. Linear slide 154 a is mounted on non-rotating plate 156 a and linear slide 154 b is mounted on non-rotating plate 156 b. The presence of the second non-rotating plate 156 b, linear slide 154 b and connecting link 130 b is optional but contributes to providing a rigid frame upon which the connecting links and associated blades may slide without misalignment relative to the reference circle.
    [0061] FIGS. 8[0061] a and 8 b illustrate the use of the inventive apparatus in various stages of the size reduction process. In FIG. 8a, stent 180 has been placed in tubular aperture 162 which is characterized by a diameter d1. In FIG. 8b, the device has been actuated by rotating actuation plate 142 so as to move blades 106 inward. Aperture 162, as shown in FIG. 8b is characterized by a diameter d2 which is reduced relative to diameter d1. Stent 180 is seen to be of reduced diameter relative to its previous diameter as shown in FIG. 8a.
    [0062] FIG. 8[0062] c differs from FIG. 8b, only in that stent 180 has been crimped onto catheter 184 in FIG. 8c.
    [0063] Blades [0063] 106 may be made of any suitable, hard material including hardened steel. Desirably, the blades will be made of a material such as zirconia ceramic. Blades made of zirconia ceramic may be used without lubrication. Furthermore, because of their low thermal conductivity, they may be used to create a highly insulated chamber suitable for cryogenic processing of martensite in nitinol stents.
    [0064] Such an embodiment is shown in FIG. 9. Stent [0064] 180 is disposed between blades 106 which can move inward in the direction of the arrows. Blades 106 are cooled by a first source of cooling fluid 184 located at first end 174 of blades 106. Although not shown, a second source of cooling fluid may be provided at second end 178 of blades 106 as well. The cooling fluid may be a liquid cryogenic. Exemplary cryogenics include liquid nitrogen, argon or carbon dioxide although other cryogens may also be used. The cooling fluid may also be a chilled gas such as air. The cooling fluid may also be a cooled inert gas such as nitrogen, argon or other inert gasses.
    [0065] The aperture formed by the blades is a highly insulated chamber which is suitable for cryogenic processing of martensite in nitinol stents. The chamber is maintained at −80° C. and a nitinol stent inserted therein. Upon equilibration of the temperature of the stent, the blades are moved inward to reduce the diameter of the stent. The stent is thus reduced in diameter while being maintained in the martensitic state. [0065]
    [0066] The embodiment of FIG. 9 further has a loading plunger [0066] 188 for loading a stent or other suitable medical device into the aperture. A sheath housing 192 which houses sheath 196 is provided at second end 178 of blades 106. Plunger 188 may be further used to transfer the stent after it has been reduced in diameter or size to sheath 196. Desirably, sheath 196 will have a slightly larger diameter than stent 180 following reduction in size of the stent. More desirably, the fit of the stent within the sheath will be within about {fraction (1/32)}″ and even more desirably, within about {fraction (1/64)}″.
    [0067] Where lengthy stents or other medical devices are to be reduced in size, the invention contemplates using one of the above described apparatuses with long blades to accommodate the stent. As an alternative, the invention also contemplates disposing two or more of such apparatuses sequentially to form one long aperture. The two or more apertures may then be reduced in size simultaneously or consecutively. The arrangement of FIG. 10 shows an embodiment with three devices [0067] 100 a-c arranged sequentially. A stepped reduction in size may be achieved by placing a stent 180 or similar medical device in the apparatus and independently reducing each aperture 118 a-c to a desired size. To that end, the invention may provide particular utility in manipulating bifurcated stents or other stents whose diameter varies along its length. The embodiment of FIG. 10 shows the end portions of the stent being reduced in size prior to the middle portion of the stent. The device may also be operated so as to reduce the middle portion in size prior to the end portions or in any other sequence.
    [0068] The invention contemplates yet another approach to reducing the diameter of lengthy stents or similar medical devices, namely walking the stent through the apparatus. This may be accomplished by either moving the stent relative to the apparatus or moving the apparatus relative to the stent as shown schematically in FIG. 11. To that end, stent [0068] 180 is inserted in device 100. Aperture 118 a is reduced in size with blades 106 a in turn reducing portion 180 a of stent 180 in size. Aperture 118 a is then opened and aperture 118 b reduced in size thereby reducing portion 180 b of stent 180. Simultaneously, or shortly thereafter, sheath 196 is pushed by plunger 188 over the portion of the stent that has been reduced in size. Aperture 118 b is opened and the stent advanced in the apparatus. The process is repeated until the entire length, or the desired portion of the stent or medical device is reduced in size.
    [0069] The reduction in size of the stent or other medical device may occur as part of a precrimping step or it may occur as part of crimping a stent onto a catheter and desirably, onto a balloon disposed about a catheter. In a general sense, it may be used for manipulating a medical device and specifically, for applying a radial inward force to a medical device. [0069]
    [0070] In another embodiment, the invention is directed to a method of manipulating a medical device. As part of the method, a medical device such as those disclosed above is provided. The device has at least three blades capable of applying a radial inward force. The blades are disposed about a reference circle to form a shrinkable aperture. The blades are constructed and arranged such that each blade has only a single point which a) lies on the circumference of the reference circle prior to movement of the blade, and b) is moved along a radius of the reference circle on movement of the blade. The medical device is placed into the shrinkable aperture and the blades simultaneously moved inward to apply a radial inward force to the medical device and thereby reduce the medical device in size, and desirably, in diameter. Following reduction in size of the medical device, the blades are simultaneously moved outward and the medical device removed from the aperture. [0070]
    [0071] The inventive apparatus may also be incorporated into a blow molding tool to provide a variable size balloon mold as shown generally at [0071] 100 in FIG. 12. The various parts of the apparatus of FIG. 12 have been discussed in conjunction with FIGS. 8a-c and, with exception of balloon 181 and mold cavity ends 193, the reference numerals used in FIG. 12 correspond to those used for FIGS. 8a-c. Mold cavity ends 193 may be provided in a variety of sizes and lengths to contain the balloon at each end. Desirably, the end molds will be adjustably mounted to a portion of the apparatus such as fixed plates 156 to provide for an adjustable length balloon mold.
    [0072] The invention is also directed to a method for molding a medical balloon using the inventive apparatus described above. A balloon preform prepared through any standard method is provided. The inventive mold, shown generally at [0072] 100 is also provided. Balloon 181 is inserted into aperture 162. Aperture 162 is optionally reduced to a predetermined size and the preform expanded using standard techniques. An inflation fluid, for example, may be supplied to the preform and the preform expanded and heated. The balloon in its expanded state is shown in FIG. 12.
    [0073] More generally, the invention may be practiced by providing at least three movable blades disposed about a reference tube to form a shrinkable tubular aperture. The blades are constructed and arranged such that each blade has a single line which a) lies on the surface of the reference tube prior to movement of the blade, and b) is moved along a radial plane of the reference tube on movement of the blade. A balloon preform is placed into the shrinkable aperture. The aperture may be set at a predetermined size prior to or following insertion of the balloon therein. An inflation fluid is provided and the balloon preform inflated so that the preform expands to the size of the aperture. The preform may be heated during this inflation blowing step. The inflation fluid is then removed from the thus formed balloon and the balloon removed from the apparatus. [0073]
    [0074] The balloon may be also be molded in accordance with the method described in U.S. Pat. No. 5,163,989, or in accordance with other methods as are known to those of ordinary skill in the art, substituting the instant apparatus for the standard balloon mold. Other patents which discuss balloon molding include U.S. Pat. No. 5,807,520. Other references illustrating the materials and methods of making catheter balloons include: U.S. Pat. No. 4,413,989 and U.S. Pat. No. 4,456,000 to Schjeldahl et al, U.S. Pat. No. 4,490,421, U.S. Pat. No. Re 32,983 and U.S. Pat. No. Re 33,561 to Levy, and U.S. Pat. No. 4,906,244, U.S. Pat. No. 5,108,415 and U.S. Pat. No. 5,156,612 to Pinchuck et al. [0074]
    [0075] The use of the inventive apparatus as a mold allows for the blowing of a balloon to a predetermined size using a single adjustable size balloon mold thereby eliminating the need to have multiple molds of different sizes. [0075]
    [0076] The invention further contemplates molding a balloon to a desired shape using a plurality of the inventive devices arranged sequentially. As an example of this, shown in FIG. 13, a stepped balloon [0076] 181 may be prepared by arranging several devices 100 a, 100 b and 100 c sequentially. A balloon preform is inserted in the aperture formed by the device. The aperture of each device may be preset at a desired size or may be reduced in size to a predetermined size after the balloon preform is inserted therein. The balloon may then be blow molded in accordance with any suitable blow molding technique known in the art.
    [0077] The invention is also understood to be directed to embodiments employing various combinations of the features disclosed herein. [0077]
    [0078] The above disclosure is intended to be illustrative and not exhaustive. This description will suggest many variations and alternatives to one of ordinary skill in this art. All these alternatives and variations are intended to be included within the scope of the attached claims. Those familiar with the art may recognize other equivalents to the specific embodiments described herein which equivalents are also intended to be encompassed by the claims attached hereto. [0078]
    权利要求:
    Claims (26)
    [1" id="US-20010001890-A1-CLM-00001] 1. An apparatus for reducing in size a medical device comprising:
    at least three coupled movable blades disposed about a reference circle to form an aperture whose size may be varied, the aperture capable of being sized to contain the medical device,
    each blade in communication with an actuation device which is capable of moving the blade to alter the size of the aperture,
    wherein each blade includes a single radial point which
    a) lies on a radial line of the reference circle prior to movement of the blade, and
    b) may be moved only along the radial line of the reference circle on movement of the blade.
    [2" id="US-20010001890-A1-CLM-00002] 2. The apparatus of
    claim 1 wherein the blades are constructed and arranged to form a shrinkable polygonal aperture.
    [3" id="US-20010001890-A1-CLM-00003] 3. The apparatus of
    claim 1 wherein the blades are constructed and arranged to form a substantially circular aperture.
    [4" id="US-20010001890-A1-CLM-00004] 4. The apparatus of
    claim 1 wherein the actuation device comprises
    a cam, and
    a plurality of linear slide devices,
    each of the linear slide devices in mechanical communication with the cam,
    and each blade is mounted to a linear slide device,
    each linear slide device movable along an axis parallel to the radius on which the radial point of the blade lies.
    [5" id="US-20010001890-A1-CLM-00005] 5. The apparatus of
    claim 1 comprising from 4 to 16 blades.
    [6" id="US-20010001890-A1-CLM-00006] 6. The apparatus of
    claim 5 comprising 8 blades.
    [7" id="US-20010001890-A1-CLM-00007] 7. The apparatus of
    claim 1 wherein the blades are disposed about a reference tube to form a tubular aperture whose size may be varied, the reference circle lying along the reference tube,
    each blade in communication with an actuation device which is capable of moving the blade to alter the size of the tubular aperture,
    each blade includes a single line which
    a) lies on the circumference of the reference tube prior to movement of the blade, and
    b) may be moved only along a radial plane of the reference tube on movement of the blade.
    [8" id="US-20010001890-A1-CLM-00008] 8. The apparatus of
    claim 7 wherein the reference tube is a cylinder.
    [9" id="US-20010001890-A1-CLM-00009] 9. The apparatus of
    claim 1 in combination with a medical device which may be reduced in size, the medical device selected from the group consisting of stents, grafts stent-grafts and vena cava filters.
    [10" id="US-20010001890-A1-CLM-00010] 10. The apparatus of
    claim 1 wherein each blade has an inner end and an outer end, the inner end being beveled to form a tip.
    [11" id="US-20010001890-A1-CLM-00011] 11. The apparatus of
    claim 13 wherein the single radial point on each blade is at the tip of the blade
    [12" id="US-20010001890-A1-CLM-00012] 12. An apparatus for applying a radial inward force to a medical device comprising:
    at least three coupled movable blades disposed about a reference circle to form an aperture whose size may be varied, the aperture capable of being sized to contain the medical device,
    each blade in communication with an actuation device which is capable of moving the blade to alter the size of the aperture,
    wherein each blade includes a single radial point which
    a) lies on the circumference of the reference circle prior to movement of the blade, and
    b) may be moved only along a radius of the reference circle on movement of the blade.
    [13" id="US-20010001890-A1-CLM-00013] 13. The apparatus of
    claim 12 with a medical device selected from the group consisting of stents, grafts, stent-grafts and vena cava filters disposed in the aperture.
    [14" id="US-20010001890-A1-CLM-00014] 14. The apparatus of
    claim 13 wherein the medical device is disposed about a catheter.
    [15" id="US-20010001890-A1-CLM-00015] 15. An apparatus for crimping a medical device comprising:
    at least three coupled movable blades disposed about a reference circle to form an aperture whose size may be varied, the aperture capable of being sized to contain the medical device,
    each blade in communication with an actuation device which is capable of moving the blade to alter the size of the aperture,
    wherein each blade includes a single radial point which
    a) lies on the circumference of the reference circle prior to movement of the blade, and
    b) may be moved only along a radius of the reference circle on movement of the blade.
    [16" id="US-20010001890-A1-CLM-00016] 16. A method of manipulating a medical device comprising the steps of:
    providing a medical device;
    providing at least three blades capable of applying a radial inward force, the blades disposed about a reference circle to form a shrinkable aperture;
    placing the medical device into the shrinkable aperture;
    simultaneously moving the blades inward to apply a radial inward force to the medical device;
    wherein the blades are constructed and arranged such that each blade has a single point which
    a) lies on the circumference of the reference circle prior to movement of the blade, and
    b) is moved along a radius of the reference circle on movement of the blade.
    [17" id="US-20010001890-A1-CLM-00017] 17. The method of
    claim 16 wherein the medical device is selected from the group consisting of stents, stent-grafts, grafts and vena cava filters.
    [18" id="US-20010001890-A1-CLM-00018] 18. The method of
    claim 17 wherein the medical device is reduced in size.
    [19" id="US-20010001890-A1-CLM-00019] 19. The method of
    claim 17 wherein the medical device is characterized by a diameter and the diameter is reduced in size.
    [20" id="US-20010001890-A1-CLM-00020] 20. The method of
    claim 17 wherein the medical device is disposed about a catheter.
    [21" id="US-20010001890-A1-CLM-00021] 21. The method of
    claim 17 wherein the medical device is disposed about a balloon which is disposed about a catheter.
    [22" id="US-20010001890-A1-CLM-00022] 22. The method of
    claim 20 wherein a sufficient radial inward force is applied to crimp the medical device to the catheter.
    [23" id="US-20010001890-A1-CLM-00023] 23. The method of
    claim 21 further comprising the steps of:
    simultaneously moving the blades outward; and
    removing the medical device from the aperture.
    [24" id="US-20010001890-A1-CLM-00024] 24. A method of molding a balloon comprising the steps of:
    providing a balloon preform;
    providing at least three movable blades disposed about a reference tube to form a shrinkable tubular aperture, wherein the blades are constructed and arranged such that each blade has a single line which
    a) lies on the surface of the reference tube prior to movement of the blade, and
    b) is moved along a radial plane of the reference tube on movement of the blade;
    placing the balloon preform into the shrinkable aperture;
    providing an inflation fluid; and
    inflating the balloon preform so that the preform contacts the blades.
    [25" id="US-20010001890-A1-CLM-00025] 25. The method of
    claim 24 wherein the balloon is heated during the inflating step to form a balloon.
    [26" id="US-20010001890-A1-CLM-00026] 26. The method of
    claim 25 wherein the inflation fluid is removed from the formed balloon and the balloon is removed from the aperture.
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    同族专利:
    公开号 | 公开日
    WO2001021103A9|2002-10-03|
    US20030192164A1|2003-10-16|
    EP1214018B1|2007-02-14|
    US8533925B2|2013-09-17|
    US6915560B2|2005-07-12|
    US7992273B2|2011-08-09|
    WO2001021103A2|2001-03-29|
    AU7589500A|2001-04-24|
    US20100154195A1|2010-06-24|
    US20050240256A1|2005-10-27|
    EP1214018A2|2002-06-19|
    US7587801B2|2009-09-15|
    US20110258833A1|2011-10-27|
    US20020035774A1|2002-03-28|
    US6360577B2|2002-03-26|
    WO2001021103A3|2001-10-18|
    US6823576B2|2004-11-30|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US6568235B1|2000-08-10|2003-05-27|Advanced Cardiovascular Systems, Inc.|Assembly for crimping an intraluminal device or measuring the radial strength of the intraluminal device and method of use|
    US20050159802A1|2004-01-15|2005-07-21|Icon Interventional Systems, Inc., An Ohio Corporation|Method for verifying position on an angioplasty balloon|
    US20050183259A1|2004-02-23|2005-08-25|Tracee Eidenschink|Apparatus and method for crimping a stent assembly|
    US20050188525A1|2004-02-26|2005-09-01|Scimed Life Systems, Inc.|Crimper|
    WO2005099967A1|2004-04-16|2005-10-27|Qualimed Innovative Medizinprodukte Gmbh|Device for reducing the diameter of a stent|
    US20060036310A1|2004-08-13|2006-02-16|Scimed Life Systems, Inc.|Method to simultaneously load and cover self expanding stents|
    US20060100689A1|2004-11-10|2006-05-11|Medtronic Vascular, Inc.|Stent crimper with slit sheath|
    US20060229712A1|2005-04-12|2006-10-12|Advanced Cardiovascular Systems, Inc.|Method of stent mounting to form a balloon catheter having improved retention of a drug delivery stent|
    US20060230592A1|2005-04-19|2006-10-19|Boston Scientific Scimed, Inc.|Loading stent with compressed air|
    JP2012115685A|2004-06-16|2012-06-21|Machine Solutions Inc|Tissue prosthesis processing technology|
    US8221112B2|2005-04-12|2012-07-17|Abbott Cardiovascular Systems, Inc.|Method for retaining a vascular stent on a catheter|
    US8333003B2|2008-05-19|2012-12-18|Boston Scientific Scimed, Inc.|Bifurcation stent crimping systems and methods|
    CN103660264A|2013-11-18|2014-03-26|广州医科大学附属第一医院|Three-fold folding machine of balloon|
    WO2014179505A1|2013-04-30|2014-11-06|Interface Associates, Inc.|Gripping system for straightening a balloon catheter during fluting|
    US9078781B2|2006-01-11|2015-07-14|Medtronic, Inc.|Sterile cover for compressible stents used in percutaneous device delivery systems|
    WO2015183881A1|2014-05-28|2015-12-03|Machine Solutions, Inc.|Segmental crimper having individually heated crimper segments and method of using the same|
    US9833600B2|2005-12-16|2017-12-05|Interface Associates, Inc.|Methods for manufacturing multi-layer balloons for medical applications|
    US10357363B2|2016-06-09|2019-07-23|Medtronic Vascular, Inc.|Transcatheter valve delivery system with crimped prosthetic heart valve|US565257A||1896-08-04||Apparatus for forming couplings for pipe-sections |
    US758195A|1902-08-02|1904-04-26|George H F Schrader|Machine for contracting ferrules, &c.|
    US1665915A|1925-12-21|1928-04-10|Albert C Ekman|Pipe-swaging device|
    US1889795A|1928-12-04|1932-12-06|Frank H Smith|Method of joining pipes|
    US2292421A|1938-09-08|1942-08-11|United Metal Hose Company Inc|Hose coupling-method of and means for forming same|
    US2751077A|1952-05-23|1956-06-19|Okonite Co|Extrusion apparatus for sheathing electric cables|
    US2887222A|1956-03-23|1959-05-19|Okonite Co|Extrusion apparatus for sheathing electric cables|
    US2986192A|1957-05-07|1961-05-30|W D Allen Mfg Co|Apparatus and method for connecting couplings to hose|
    US3084389A|1960-07-25|1963-04-09|Phillips Petroleum Co|Plastic molding process and apparatus|
    DE1924691U|1965-01-29|1965-09-30|Bernd Ribback|PRESS OD. DGL. FOR PLASTIC DEFORMING.|
    IL32989A|1969-09-11|1972-07-26|Anati R|A wrench|
    US3695087A|1970-08-26|1972-10-03|Arthur H Tuberman|Method and apparatus for pointing tubes|
    GB1370615A|1970-12-03|1974-10-16|Btr Industries Ltd|Crimping or swaging apparatus|
    US3731518A|1971-05-26|1973-05-08|G Blocher|Crimping die arrangement|
    US4164523A|1976-09-09|1979-08-14|Robert Hanning|Method of injection-molding and cooling of shaped synthetic-resin bodies|
    US4350036A|1980-02-07|1982-09-21|Vale Industries Inc.|Apparatus for pointing work pieces|
    US4454657A|1980-07-25|1984-06-19|Japan Aviation Electronics Industry Limited|Aperture setting device|
    GB2081144B|1980-08-01|1983-10-12|Sigma Koncern|An arrangement for the radial forming of bodies|
    US4456000A|1981-08-17|1984-06-26|Angiomedics Corporation|Expandable occlusion apparatus|
    US4413989A|1980-09-08|1983-11-08|Angiomedics Corporation|Expandable occlusion apparatus|
    US4404827A|1981-07-10|1983-09-20|Union Carbide Corporation|Method and apparatus for drawing wire|
    US4490421A|1983-07-05|1984-12-25|E. I. Du Pont De Nemours And Company|Balloon and manufacture thereof|
    USRE32983E|1983-07-05|1989-07-11|E. I. Du Pont De Nemours And Company|Balloon and manufacture thereof|
    USRE33561E|1983-07-05|1991-03-26|E. I. Du Pont De Nemours And Company|Balloon and manufacture thereof|
    DE3331721C2|1983-09-02|1986-06-05|Peter 6000 Frankfurt Schröck|Radial press for workpieces with a cylindrical outer surface|
    PL144225B1|1984-07-18|1988-04-30|Jan Charzewski|Apparatus for shaping material in particular plastic ones and method of manufacturing articles of varying cross-section|
    US5358486A|1987-01-09|1994-10-25|C. R. Bard, Inc.|Multiple layer high strength balloon for dilatation catheter|
    AT86896T|1988-06-30|1993-04-15|Karl Sauder|RADIAL PRESS FOR ESSENTIAL CYLINDRICAL WORKPIECES.|
    US5108415A|1988-10-04|1992-04-28|Cordis Corporation|Balloons for medical devices and fabrication thereof|
    US5156612A|1988-10-04|1992-10-20|Cordis Corporation|Balloons for medical devices and fabrication thereof|
    US4906244A|1988-10-04|1990-03-06|Cordis Corporation|Balloons for medical devices and fabrication thereof|
    US5171583A|1988-10-21|1992-12-15|The Regents Of The University Of California|Treatment of osteoporosis using potassium bicarbonate|
    US4854031A|1989-02-09|1989-08-08|The Goodyear Tire & Rubber Company|Hose crimper and method of using same|
    EP0408245B1|1989-07-13|1994-03-02|American Medical Systems, Inc.|Stent placement instrument|
    DE69002295T2|1989-09-25|1993-11-04|Schneider Usa Inc|MULTILAYER EXTRUSION AS A METHOD FOR PRODUCING BALLOONS FOR VESSEL PLASTICS.|
    US5087394A|1989-11-09|1992-02-11|Scimed Life Systems, Inc.|Method for forming an inflatable balloon for use in a catheter|
    US5672167A|1990-05-21|1997-09-30|Recordati Corporation|Controlled release osmotic pump|
    US5163989A|1990-08-27|1992-11-17|Advanced Cardiovascular Systems, Inc.|Method for forming a balloon mold and the use of such mold|
    JP2555298B2|1990-11-10|1996-11-20|テルモ株式会社|CATHETER BALLOON, CATHETER BALLOON MANUFACTURING METHOD, AND BALLOON CATHETER|
    US5114327A|1991-01-25|1992-05-19|Williamson James T|Rapid cooling apparatus for an injection molding machine|
    US5195350A|1991-04-25|1993-03-23|E. I. Du Pont De Nemours And Company|Method for forming features on an elongated metal wire|
    JPH05192408A|1991-09-06|1993-08-03|C R Bard Inc|Production of expansion balloon|
    US5183085A|1991-09-27|1993-02-02|Hans Timmermans|Method and apparatus for compressing a stent prior to insertion|
    US5290305A|1991-10-11|1994-03-01|Kanji Inoue|Appliance collapsible for insertion into human organs and capable of resilient restoration|
    JP2961287B2|1991-10-18|1999-10-12|グンゼ株式会社|Biological duct dilator, method for producing the same, and stent|
    US5275777A|1991-10-29|1994-01-04|Chuang Ming Chih|Method for making an elongated foam rod with embedded string|
    US5230352A|1992-03-04|1993-07-27|American Cyanamid Company|Medical suturing device, a single-strike die mechanism, and a method of using said die mechanism for forming the medical suturing device|
    US5261263A|1992-12-21|1993-11-16|Whitesell Eric J|Crimping pliers with radially opposed jaws|
    FR2701658B1|1993-02-19|1995-05-12|Trouvay Cauvin Sa|Apparatus for crimping a tube into a thick plate.|
    US5437083A|1993-05-24|1995-08-01|Advanced Cardiovascular Systems, Inc.|Stent-loading mechanism|
    US5735892A|1993-08-18|1998-04-07|W. L. Gore & Associates, Inc.|Intraluminal stent graft|
    US5381686A|1994-03-03|1995-01-17|Coherent Inc.|Dual-action pneumo-hydraulic crimping apparatus|
    US5733303A|1994-03-17|1998-03-31|Medinol Ltd.|Flexible expandable stent|
    AU708360B2|1994-09-15|1999-08-05|C.R. Bard Inc.|Hooked endoprosthesis|
    US5545210A|1994-09-22|1996-08-13|Advanced Coronary Technology, Inc.|Method of implanting a permanent shape memory alloy stent|
    US5836965A|1994-10-19|1998-11-17|Jendersee; Brad|Stent delivery and deployment method|
    US6395087B1|1994-12-27|2002-05-28|Visteon Global Technologies, Inc.|Method and apparatus for dispensing viscous material|
    DE19507347C1|1995-03-02|1996-09-12|Rennsteig Werkzeuge Gmbh|Crimping pliers for wire end ferrules|
    NL9500468A|1995-03-08|1996-10-01|Cordis Europ|Balloon catheter and method of making it.|
    DE29506654U1|1995-04-19|1995-06-08|Hurtado Artozon Roberto Dr Med|Spreader for stents|
    US5766057A|1995-04-19|1998-06-16|Cincinnati Milacron Inc.|Centerless grinding machine|
    US5766203A|1995-07-20|1998-06-16|Intelliwire, Inc.|Sheath with expandable distal extremity and balloon catheters and stents for use therewith and method|
    US5628754A|1995-08-01|1997-05-13|Medtronic, Inc.|Stent delivery guide catheter|
    DE19532288A1|1995-09-01|1997-03-06|Ulrich Dipl Phys Dr M Solzbach|Aid for applying stent on balloon of dilation catheter|
    EP0861104B1|1995-11-08|2000-12-27|SciMed Life Systems, Inc.|Method of balloon formation by cold drawing/necking|
    US5746764A|1995-12-04|1998-05-05|Atrion Medical Products, Inc.|Stent compression instrument|
    US5626604A|1995-12-05|1997-05-06|Cordis Corporation|Hand held stent crimping device|
    US5935476A|1996-01-16|1999-08-10|Linlan Induction Ab|Device for heating a press tool using magnetic induction heating; press having such a device, and method of manufacture|
    US5674106A|1996-02-08|1997-10-07|Royal Masters Grinders, Inc.|Centerless grinder assembly and method of operating the same|
    US5749921A|1996-02-20|1998-05-12|Medtronic, Inc.|Apparatus and methods for compression of endoluminal prostheses|
    US5630830A|1996-04-10|1997-05-20|Medtronic, Inc.|Device and method for mounting stents on delivery systems|
    US5672169A|1996-04-10|1997-09-30|Medtronic, Inc.|Stent mounting device|
    TW340089B|1996-05-28|1998-09-11|Idemitsu Petrochemical Co|Method and apparatus for manufacturing hollow formed items|
    US5715723A|1996-08-14|1998-02-10|Owens; Carl H.|Hose crimping apparatus|
    US5836952A|1996-08-21|1998-11-17|Cordis Corporation|Hand-held stent crimper|
    US5911752A|1996-09-13|1999-06-15|Intratherapeutics, Inc.|Method for collapsing a stent|
    US5725519A|1996-09-30|1998-03-10|Medtronic Instent Israel Ltd.|Stent loading device for a balloon catheter|
    US5893867A|1996-11-06|1999-04-13|Percusurge, Inc.|Stent positioning apparatus and method|
    US5860966A|1997-04-16|1999-01-19|Numed, Inc.|Method of securing a stent on a balloon catheter|
    US5972016A|1997-04-22|1999-10-26|Advanced Cardiovascular Systems, Inc.|Stent crimping device and method of use|
    US5810871A|1997-04-29|1998-09-22|Medtronic, Inc.|Stent delivery system|
    US5810873A|1997-07-15|1998-09-22|Advanced Cardiovascular Systems, Inc.|Stent crimping tool and method of use|
    US5918511A|1997-08-28|1999-07-06|Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College|Adjustable socket wrench|
    US6167605B1|1997-09-12|2001-01-02|Advanced Cardiovascular Systems, Inc.|Collet type crimping tool|
    US5992000A|1997-10-16|1999-11-30|Scimed Life Systems, Inc.|Stent crimper|
    US6018857A|1997-10-30|2000-02-01|Ave Connaught|Device and method for mounting a stent onto a balloon catheter|
    US5920975A|1997-11-03|1999-07-13|Advanced Cardiovascular Systems, Inc.|Stent crimping tool and method of use|
    US6033380A|1998-02-13|2000-03-07|Cordis Corporation|Six-pleated catheter balloon and device for forming same|
    US6082990A|1998-02-17|2000-07-04|Advanced Cardiovascular Systems, Inc.|Stent crimping tool|
    US6024737A|1998-02-25|2000-02-15|Advanced Cardiovascular Systems, Inc.|Stent crimping device|
    US6063092A|1998-04-07|2000-05-16|Medtronic Inc.|Heat set and crimping process to optimize stent retention|
    US5931851A|1998-04-21|1999-08-03|Advanced Cardiovascular Systems, Inc.|Method and apparatus for rubber-tube crimping tool with premount stent|
    US6009614A|1998-04-21|2000-01-04|Advanced Cardiovascular Systems, Inc.|Stent crimping tool and method of use|
    US6296655B1|1998-04-27|2001-10-02|Advanced Cardiovascular Systems, Inc.|Catheter balloon with biased multiple wings|
    US6141855A|1998-04-28|2000-11-07|Advanced Cardiovascular Systems, Inc.|Stent crimping tool and method of use|
    US5893852A|1998-04-28|1999-04-13|Advanced Cardiovascular Systems, Inc.|Stent crimping tool and method of use|
    US5974652A|1998-05-05|1999-11-02|Advanced Cardiovascular Systems, Inc.|Method and apparatus for uniformly crimping a stent onto a catheter|
    US6092273A|1998-07-28|2000-07-25|Advanced Cardiovascular Systems, Inc.|Method and apparatus for a stent crimping device|
    US6051002A|1998-10-09|2000-04-18|Advanced Cardiovascular Systems, Inc.|Stent crimping device and method of use|
    US5951540A|1998-10-22|1999-09-14|Medtronic, Inc.|Device and method for mounting stents|
    US6074381A|1998-10-22|2000-06-13|Isostent, Inc.|Cylindrical roller stent crimper apparatus with radiation shield|
    US6125523A|1998-11-20|2000-10-03|Advanced Cardiovascular Systems, Inc.|Stent crimping tool and method of use|
    US6364870B1|1998-12-22|2002-04-02|Medinol Ltd.|Apparatus and method for securing a stent on a balloon|
    US6387117B1|1999-09-22|2002-05-14|Scimed Life Systems, Inc.|Stent crimping system|
    US6360577B2|1999-09-22|2002-03-26|Scimed Life Systems, Inc.|Apparatus for contracting, or crimping stents|
    US6309383B1|2000-01-20|2001-10-30|Isostent, Inc.|Stent crimper apparatus with radiation shied|
    US6568235B1|2000-08-10|2003-05-27|Advanced Cardiovascular Systems, Inc.|Assembly for crimping an intraluminal device or measuring the radial strength of the intraluminal device and method of use|
    US7152452B2|2002-12-26|2006-12-26|Advanced Cardiovascular Systems, Inc.|Assembly for crimping an intraluminal device and method of use|
    US7143625B2|2004-04-16|2006-12-05|Boston Scientific Scimed, Inc.|Stent crimper|US7682647B2|1999-09-03|2010-03-23|Advanced Cardiovascular Systems, Inc.|Thermal treatment of a drug eluting implantable medical device|
    US7807211B2|1999-09-03|2010-10-05|Advanced Cardiovascular Systems, Inc.|Thermal treatment of an implantable medical device|
    US8632845B2|2000-12-28|2014-01-21|Abbott Cardiovascular Systems Inc.|Method of drying bioabsorbable coating over stents|
    US6360577B2|1999-09-22|2002-03-26|Scimed Life Systems, Inc.|Apparatus for contracting, or crimping stents|
    US6535756B1|2000-04-07|2003-03-18|Surgical Navigation Technologies, Inc.|Trajectory storage apparatus and method for surgical navigation system|
    US6629350B2|2000-06-08|2003-10-07|Tom Motsenbocker|Stent crimping apparatus and method|
    EP1179322A3|2000-08-09|2004-02-25|BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin|Stent crimping method and device|
    US6618921B1|2000-11-16|2003-09-16|Scimed Life Systems, Inc.|Bare stent ship and crimp device|
    US6802846B2|2001-02-12|2004-10-12|Ams Research Corporation|Foreign body retrieval device and method|
    US6835059B2|2001-03-06|2004-12-28|Advanced Cardiovascular Systems, Inc.|Adjustable length mold assemblies|
    DE60221810D1|2001-03-26|2007-09-27|Mach Solutions Inc|BALLONFALTTECHNOLOGIE|
    DE10120757C1|2001-04-27|2002-11-07|Vermee Frans Gmbh|Device for producing tubular packaging filled with a good|
    US20030110781A1|2001-09-13|2003-06-19|Zbigniew Zurecki|Apparatus and method of cryogenic cooling for high-energy cutting operations|
    US6863683B2|2001-09-19|2005-03-08|Abbott Laboratoris Vascular Entities Limited|Cold-molding process for loading a stent onto a stent delivery system|
    US7479149B2|2001-10-25|2009-01-20|Boston Scientific Scimed, Inc.|Balloon configuring apparatus|
    US20030145694A1|2002-02-04|2003-08-07|Zbigniew Zurecki|Apparatus and method for machining of hard metals with reduced detrimental white layer effect|
    US20070032853A1|2002-03-27|2007-02-08|Hossainy Syed F|40-O-ethyl-rapamycin coated stent|
    EP1545809B1|2002-08-16|2014-06-04|Machine Solutions, Inc.|Swaging apparatus|
    US20050282445A1|2003-08-19|2005-12-22|Kelly William D|Crimp tool for crimping pin and socket contacts|
    US7162909B2|2002-08-28|2007-01-16|Daniels Manufacturing Corporation|Crimp tool for crimping pin and socket contacts|
    US7758636B2|2002-09-20|2010-07-20|Innovational Holdings Llc|Expandable medical device with openings for delivery of multiple beneficial agents|
    US20040073294A1|2002-09-20|2004-04-15|Conor Medsystems, Inc.|Method and apparatus for loading a beneficial agent into an expandable medical device|
    US7152452B2|2002-12-26|2006-12-26|Advanced Cardiovascular Systems, Inc.|Assembly for crimping an intraluminal device and method of use|
    US7487579B2|2003-03-12|2009-02-10|Boston Scientific Scimed, Inc.|Methods of making medical devices|
    US7096554B2|2003-04-04|2006-08-29|Boston Scientific Scimed, Inc.|Protective loading of stents|
    GB0309616D0|2003-04-28|2003-06-04|Angiomed Gmbh & Co|Loading and delivery of self-expanding stents|
    GB0322511D0|2003-09-25|2003-10-29|Angiomed Ag|Lining for bodily lumen|
    US7419498B2|2003-10-21|2008-09-02|Nmt Medical, Inc.|Quick release knot attachment system|
    JP2007512908A|2003-12-01|2007-05-24|アドヴァンスドカーディオヴァスキュラーシステムズ，インコーポレイテッド|Temperature adjustable crimping method|
    US20050118344A1|2003-12-01|2005-06-02|Pacetti Stephen D.|Temperature controlled crimping|
    FR2863785B1|2003-12-11|2006-04-28|Airbus France|DEVICE FOR CRIMPING A CONTACT ON A CABLE|
    US7284401B2|2004-01-12|2007-10-23|Boston Scientific Scimed, Inc.|Stent reducing system and device|
    US7316147B2|2004-01-29|2008-01-08|Boston Scientific Scimed, Inc.|Apparatuses for crimping and loading of intraluminal medical devices|
    US7480973B2|2004-03-01|2009-01-27|Boston Scientific Scimed, Inc.|Automated marker band nest placement crimper|
    WO2006071245A1|2004-12-29|2006-07-06|Boston Scientific Limited|Medical devices including metallic films and methods for loading and deploying same|
    US8998973B2|2004-03-02|2015-04-07|Boston Scientific Scimed, Inc.|Medical devices including metallic films|
    US8591568B2|2004-03-02|2013-11-26|Boston Scientific Scimed, Inc.|Medical devices including metallic films and methods for making same|
    US20050197687A1|2004-03-02|2005-09-08|Masoud Molaei|Medical devices including metallic films and methods for making same|
    ITTO20040135A1|2004-03-03|2004-06-03|Sorin Biomedica Cardio Spa|CARDIAC VALVE PROSTHESIS|
    US7513121B2|2004-03-25|2009-04-07|Air Products And Chemicals, Inc.|Apparatus and method for improving work surface during forming and shaping of materials|
    US7021114B2|2004-04-16|2006-04-04|Boston Scientific Scimed, Inc.|Stent crimper|
    US7143625B2|2004-04-16|2006-12-05|Boston Scientific Scimed, Inc.|Stent crimper|
    US7389670B1|2004-07-26|2008-06-24|Abbott Laboratories|Stent crimping system|
    US20140107761A1|2004-07-26|2014-04-17|Abbott Cardiovascular Systems Inc.|Biodegradable stent with enhanced fracture toughness|
    US20060020330A1|2004-07-26|2006-01-26|Bin Huang|Method of fabricating an implantable medical device with biaxially oriented polymers|
    US7634957B2|2004-09-16|2009-12-22|Air Products And Chemicals, Inc.|Method and apparatus for machining workpieces having interruptions|
    US8778256B1|2004-09-30|2014-07-15|Advanced Cardiovascular Systems, Inc.|Deformation of a polymer tube in the fabrication of a medical article|
    US8173062B1|2004-09-30|2012-05-08|Advanced Cardiovascular Systems, Inc.|Controlled deformation of a polymer tube in fabricating a medical article|
    US8043553B1|2004-09-30|2011-10-25|Advanced Cardiovascular Systems, Inc.|Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article|
    US7875233B2|2004-09-30|2011-01-25|Advanced Cardiovascular Systems, Inc.|Method of fabricating a biaxially oriented implantable medical device|
    AT507799T|2004-11-02|2011-05-15|Mach Solutions Inc|STENT WRAPPING TECHNOLOGY|
    US7762804B1|2004-12-17|2010-07-27|Interface Associates, Inc.|Balloon catheter folding and wrapping devices and methods|
    US8992592B2|2004-12-29|2015-03-31|Boston Scientific Scimed, Inc.|Medical devices including metallic films|
    US8632580B2|2004-12-29|2014-01-21|Boston Scientific Scimed, Inc.|Flexible medical devices including metallic films|
    US20060142838A1|2004-12-29|2006-06-29|Masoud Molaei|Medical devices including metallic films and methods for loading and deploying same|
    US7901447B2|2004-12-29|2011-03-08|Boston Scientific Scimed, Inc.|Medical devices including a metallic film and at least one filament|
    ITTO20050074A1|2005-02-10|2006-08-11|Sorin Biomedica Cardio Srl|CARDIAC VALVE PROSTHESIS|
    JP5020099B2|2005-02-11|2012-09-05|クックメディカルテクノロジーズエルエルシー|Method for loading an expandable medical device in a low steam environment|
    US7316148B2|2005-02-15|2008-01-08|Boston Scientific Scimed, Inc.|Protective sheet loader|
    US7748248B2|2005-03-23|2010-07-06|Boston Scientific Scimed, Inc.|Stent crimping mechanisms|
    US8468445B2|2005-03-30|2013-06-18|The Trustees Of Columbia University In The City Of New York|Systems and methods for content extraction|
    US7763198B2|2005-04-12|2010-07-27|Abbott Cardiovascular Systems Inc.|Method for retaining a vascular stent on a catheter|
    US7854760B2|2005-05-16|2010-12-21|Boston Scientific Scimed, Inc.|Medical devices including metallic films|
    US7681430B2|2005-05-25|2010-03-23|Boston Scientific Scimed, Inc.|Method and apparatus for reducing a stent|
    US8099851B2|2005-06-27|2012-01-24|Boston Scientific Scimed, Inc.|Crimping and edge protection elements|
    US7658880B2|2005-07-29|2010-02-09|Advanced Cardiovascular Systems, Inc.|Polymeric stent polishing method and apparatus|
    US7530253B2|2005-09-09|2009-05-12|Edwards Lifesciences Corporation|Prosthetic valve crimping device|
    US7526849B2|2005-10-07|2009-05-05|Boston Scientific Scimed, Inc.|Stent loader|
    US7390240B2|2005-10-14|2008-06-24|Air Products And Chemicals, Inc.|Method of shaping and forming work materials|
    US7434439B2|2005-10-14|2008-10-14|Air Products And Chemicals, Inc.|Cryofluid assisted forming method|
    EP1954221B1|2005-11-17|2011-04-20|The Cleveland Clinic Foundation|Method and apparatus for compressing intraluminal prostheses|
    US8182522B2|2005-11-17|2012-05-22|The Cleveland Clinic Foundation|Apparatus and method for delivering lined intraluminal prostheses|
    US20070123970A1|2005-11-29|2007-05-31|Boston Scientific Scimed, Inc.|Bifurcation stent with overlapping crimped struts|
    US20080004689A1|2006-01-19|2008-01-03|Linda Jahnke|Systems and Methods for Making Medical Devices|
    US20070239271A1|2006-04-10|2007-10-11|Than Nguyen|Systems and methods for loading a prosthesis onto a minimally invasive delivery system|
    US20070271990A1|2006-05-26|2007-11-29|Young Thomas M|Shutter-Type Crimper|
    US8333000B2|2006-06-19|2012-12-18|Advanced Cardiovascular Systems, Inc.|Methods for improving stent retention on a balloon catheter|
    US7828916B2|2006-07-20|2010-11-09|Abbott Cardiovascular Systems Inc.|Methods of crimping expandable medical devices|
    US8020277B2|2006-07-28|2011-09-20|Cook Medical Technologies Llc|Apparatus for compressing an expandable medical device|
    US7963142B2|2006-08-22|2011-06-21|Ed Goff|Radial compression mechanism with optimum die-to-die gap|
    US20080097588A1|2006-10-18|2008-04-24|Conor Medsystems, Inc.|Systems and Methods for Producing a Medical Device|
    US7618252B1|2006-10-24|2009-11-17|Ed Goff|Balloon pleating mechanism|
    EP2089557A2|2006-11-02|2009-08-19|Boston Scientific Limited|System and method for coating a medical device|
    US7832251B2|2006-11-15|2010-11-16|Abbott Laboratories|Patterned mold for medical device|
    US20080127707A1|2006-11-30|2008-06-05|Abbott Laboratories|Stent crimping assembly and method|
    WO2008094691A2|2007-02-01|2008-08-07|Cook Incorporated|Closure device and method for occluding a bodily passageway|
    US7886661B1|2007-02-07|2011-02-15|Ed Goff|Radial compression mechanism|
    US20080262603A1|2007-04-23|2008-10-23|Sorin Biomedica Cardio|Prosthetic heart valve holder|
    EP2190365A4|2007-05-10|2013-09-04|Oren Globerman|Expandable intramedullary nail for small bone fixation|
    EP2014257B1|2007-07-12|2010-09-08|Sorin Biomedica Cardio S.R.L.|Expandable prosthetic valve crimping device|
    US8006535B2|2007-07-12|2011-08-30|Sorin Biomedica Cardio S.R.L.|Expandable prosthetic valve crimping device|
    US9848981B2|2007-10-12|2017-12-26|Mayo Foundation For Medical Education And Research|Expandable valve prosthesis with sealing mechanism|
    US20090131920A1|2007-11-16|2009-05-21|Abbott Laboratories Vascular Enterprises Limited|Stent crimping apparatus|
    WO2009073774A1|2007-12-04|2009-06-11|Cook Incorporated|Storage and loading system for implantable medical devices|
    EP2231059B1|2007-12-04|2014-01-29|Cook Medical Technologies LLC|Tapered loading system for implantable medical devices|
    US8163001B2|2008-04-09|2012-04-24|Cook Medical Technologies Llc|Loading apparatus and method for expandable intraluminal medical devices|
    US8042251B2|2008-05-21|2011-10-25|Boston Scientific Scimed, Inc.|Systems and methods for heating and cooling during stent crimping|
    US8291570B2|2008-05-30|2012-10-23|Boston Scientific Scimed, Inc.|Methods for abluminally coating medical devices|
    US8225474B2|2008-05-30|2012-07-24|Boston Scientific Scimed, Inc.|Stent crimping device|
    US8359721B2|2008-09-04|2013-01-29|Cook Medical Technologies Llc|Sliding split-sleeve implant compressor|
    US8123793B2|2008-09-10|2012-02-28|Boston Scientific Scimed, Inc.|Pre-crimp balloon inflation|
    US8769796B2|2008-09-25|2014-07-08|Advanced Bifurcation Systems, Inc.|Selective stent crimping|
    US8821562B2|2008-09-25|2014-09-02|Advanced Bifurcation Systems, Inc.|Partially crimped stent|
    CN102215780B|2008-09-25|2015-10-14|高级分支系统股份有限公司|Part crimped stent|
    GB0818450D0|2008-10-08|2008-11-12|Angiomed Ag|Method of transferring a stent device from a crimping head to an outer sheath of a stent device delivery system|
    EP2668934B1|2008-12-12|2017-05-10|Abbott Laboratories Vascular Enterprises Limited|Process for loading a stent onto a stent delivery system|
    US8834563B2|2008-12-23|2014-09-16|Sorin Group Italia S.R.L.|Expandable prosthetic valve having anchoring appendages|
    US8112857B2|2009-01-20|2012-02-14|Abbott Laboratories Vascular Enterprises Limited|Stent crimping device|
    GB0901496D0|2009-01-29|2009-03-11|Angiomed Ag|Delivery device for delivering a stent device|
    US8715207B2|2009-03-19|2014-05-06|Sorin Group Italia S.R.L.|Universal valve annulus sizing device|
    EP2410947B1|2009-03-26|2015-05-20|Sorin Group USA, Inc.|Annuloplasty sizers for minimally invasive procedures|
    GB0909319D0|2009-05-29|2009-07-15|Angiomed Ag|Transluminal delivery system|
    US8585019B2|2009-08-20|2013-11-19|Cook Medical Technologies Llc|Loading apparatus and system for expandable intraluminal medical devices|
    EP2470122B1|2009-08-28|2019-10-09|Medtronic 3F Therapeutics, Inc.|Crimping device and method of use|
    US8501079B2|2009-09-14|2013-08-06|Abbott Cardiovascular Systems Inc.|Controlling crystalline morphology of a bioabsorbable stent|
    US20110106234A1|2009-10-30|2011-05-05|Axel Grandt|Interluminal medical treatment devices and methods|
    EP2549951B1|2010-03-24|2017-05-10|Advanced Bifurcation Systems, Inc.|Stent alignment during treatment of a bifurcation|
    CN103037815B|2010-03-24|2015-05-13|高级分支系统股份有限公司|Methods and systems for treating a bifurcation with provisional side branch stenting|
    CA2794080A1|2010-03-24|2011-09-29|Advanced Bifurcation Systems, Inc.|System and methods for treating a bifurcation|
    IT1400327B1|2010-05-21|2013-05-24|Sorin Biomedica Cardio Srl|SUPPORT DEVICE FOR VALVULAR PROSTHESIS AND CORRESPONDING CORRESPONDENT.|
    US8752261B2|2010-07-07|2014-06-17|Abbott Cardiovascular Systems Inc.|Mounting stents on stent delivery systems|
    US8539663B2|2010-08-23|2013-09-24|Abbott Cardiovascular Systems Inc.|Reducing crimping damage to polymer scaffold|
    US8562663B2|2010-10-26|2013-10-22|Medtronic Ventor Technologies Ltd.|Devices and methods for loading a prosthesis onto a delivery system|
    EP2672925B1|2011-02-08|2017-05-03|Advanced Bifurcation Systems, Inc.|Multi-stent and multi-balloon apparatus for treating bifurcations|
    WO2012109365A1|2011-02-08|2012-08-16|Advanced Bifurcation Systems, Inc.|System and methods for treating a bifurcation with a fully crimped stent|
    ES2641902T3|2011-02-14|2017-11-14|Sorin Group Italia S.R.L.|Sutureless anchoring device for cardiac valve prostheses|
    EP2486894B1|2011-02-14|2021-06-09|Sorin Group Italia S.r.l.|Sutureless anchoring device for cardiac valve prostheses|
    US9101507B2|2011-05-18|2015-08-11|Ralph F. Caselnova|Apparatus and method for proximal-to-distal endoluminal stent deployment|
    US10010412B2|2011-07-27|2018-07-03|Edwards Lifesciences Corporation|Conical crimper|
    US8574283B1|2011-08-30|2013-11-05|Suraj Govind Kamat|Deployment of stents within bifurcated vessels|
    US8652145B2|2011-12-14|2014-02-18|Edwards Lifesciences Corporation|System and method for crimping a prosthetic valve|
    CA2862126C|2011-12-31|2016-11-08|The Gates Corporation|Crimper system|
    CH705977A1|2012-01-11|2013-07-15|Qvanteq Ag|Apparatus and method for providing a stent for implantation with wrapping.|
    WO2013120082A1|2012-02-10|2013-08-15|Kassab Ghassan S|Methods and uses of biological tissues for various stent and other medical applications|
    CN102805676B|2012-08-14|2015-06-17|杭州启明医疗器械有限公司|Compression device for artificial valve replacement device|
    US9724219B2|2012-10-04|2017-08-08|Abbott Cardiovascular Systems Inc.|Method of uniform crimping and expansion of medical devices|
    CN103817505B|2012-11-19|2016-08-03|微创心脉医疗科技（上海）有限公司|Bracket assembled equipment|
    CN103815939B|2012-11-19|2017-06-27|微创心脉医疗科技（上海）有限公司|Overlay film frame tightening device and tightening up method|
    US9308569B2|2013-02-01|2016-04-12|Medtronic, Inc.|Devices and methods for crimping and loading a medical device into a delivery system|
    US9308346B2|2013-02-01|2016-04-12|Medtronic, Inc.|Devices and methods for crimping and loading a collapsible device into a delivery system|
    WO2015119653A1|2014-02-04|2015-08-13|Abbott Cardiovascular Systems Inc.|Drug delivery scaffold or stent with a novolimus and lactide based coating such that novolimus has a minimum amount of bonding to the coating|
    US9757232B2|2014-05-22|2017-09-12|Edwards Lifesciences Corporation|Crimping apparatus for crimping prosthetic valve with protruding anchors|
    US10098768B2|2014-09-15|2018-10-16|Cook Medical Technologies Llc|Ratchet operated vascular intervention device delivery system|
    JP6547541B2|2015-09-17|2019-07-24|日本ゼオン株式会社|Diameter reduction device|
    US10639147B2|2016-06-24|2020-05-05|Edwards Lifesciences Corporation|System and method for crimping a prosthetic valve|
    US10716691B2|2016-06-24|2020-07-21|Edwards Lifesciences Corporation|Compact crimping device|
    WO2018064690A1|2016-09-28|2018-04-05|Strait Access Technologies HoldingsLtd|Crimping device|
    US10537450B2|2016-12-29|2020-01-21|Boston Scientific Scimed, Inc.|Method for loading a stent into a delivery device|
    US10660773B2|2017-02-14|2020-05-26|Abbott Cardiovascular Systems Inc.|Crimping methods for thin-walled scaffolds|
    US10709591B2|2017-06-06|2020-07-14|Twelve, Inc.|Crimping device and method for loading stents and prosthetic heart valves|
    US10555825B2|2017-11-09|2020-02-11|Abbott Cardiovascular Systems Inc.|Rotation of a medical device during crimping|
    US10967556B2|2018-06-11|2021-04-06|Abbott Cardiovascular Systems Inc.|Uniform expansion of thin-walled scaffolds|
    KR102338328B1|2019-11-27|2021-12-13|태웅메디칼|Stent crimping device for catheter|
    CN111644841B|2020-05-13|2021-10-19|杭州沃镭智能科技股份有限公司|Solenoid valve booster valve assembly quality|
    法律状态:
    1999-09-22| AS| Assignment|Owner name: SCIMED LIFE SYSTEMS, INC., MINNESOTA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:AUSTIN, MICHAEL;REEL/FRAME:010271/0062 Effective date: 19990804 |
    2002-03-08| STCF| Information on status: patent grant|Free format text: PATENTED CASE |
    2005-08-26| FPAY| Fee payment|Year of fee payment: 4 |
    2006-11-06| AS| Assignment|Owner name: BOSTON SCIENTIFIC SCIMED, INC., MINNESOTA Free format text: CHANGE OF NAME;ASSIGNOR:SCIMED LIFE SYSTEMS, INC.;REEL/FRAME:018505/0868 Effective date: 20050101 Owner name: BOSTON SCIENTIFIC SCIMED, INC.,MINNESOTA Free format text: CHANGE OF NAME;ASSIGNOR:SCIMED LIFE SYSTEMS, INC.;REEL/FRAME:018505/0868 Effective date: 20050101 |
    2009-08-21| FPAY| Fee payment|Year of fee payment: 8 |
    2013-08-28| FPAY| Fee payment|Year of fee payment: 12 |
    优先权:
    申请号 | 申请日 | 专利标题
    US09/401,218|US6360577B2|1999-09-22|1999-09-22|Apparatus for contracting, or crimping stents|
    US09/966,686|US6823576B2|1999-09-22|2001-10-01|Method and apparatus for contracting, loading or crimping self-expanding and balloon expandable stent devices|
    US10/444,807|US6915560B2|1999-09-22|2003-05-23|Apparatus for contracting, loading or crimping self-expanding and balloon expandable stent devices|US09/401,218| US6360577B2|1999-09-22|1999-09-22|Apparatus for contracting, or crimping stents|
    EP00965124A| EP1214018B1|1999-09-22|2000-09-18|Method and apparatus for reducing in size a medical device|
    AT00965124T| AT353606T|1999-09-22|2000-09-18|METHOD AND DEVICE FOR REDUCING A MEDICAL DEVICE|
    PCT/US2000/025588| WO2001021103A2|1999-09-22|2000-09-18|A method for contracting, loading or crimping self-expanding and balloon expandable stent devices|
    AU75895/00A| AU7589500A|1999-09-22|2000-09-18|A method for contracting, loading or crimping self-expanding and balloon expandable stent devices|
    DE60033411T| DE60033411D1|1999-09-22|2000-09-18|Method and device for downsizing a medical device|
    US09/966,686| US6823576B2|1999-09-22|2001-10-01|Method and apparatus for contracting, loading or crimping self-expanding and balloon expandable stent devices|
    US10/444,807| US6915560B2|1999-09-22|2003-05-23|Apparatus for contracting, loading or crimping self-expanding and balloon expandable stent devices|
    US11/159,490| US7587801B2|1999-09-22|2005-06-23|Stent crimper|
    US12/537,044| US7992273B2|1999-09-22|2009-08-06|Crimping apparatus for reducing size of a stent|
    US13/180,099| US8533925B2|1999-09-22|2011-07-11|Method for contracting or crimping stents|
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