• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    A novel cosmetic is obtained by mechanical mixing of a 0.6-0.8% solution of a collagen and adding thereto from 0.6-1% of pyridoxal phosphate.
    公开号:SU969271A1
    申请号:SU787770239
    申请日:1978-07-03
    公开日:1982-10-30
    发明作者:Върбанов Буров Пенчо；Атанасова Кюлева Надежда
    申请人:Дсо "Фармахим" (Инопредприятие)；
    IPC主号:
    专利说明:

    The invention relates to a cosmetic product based on collagen and a method for its preparation.
    Known cosmetics. consisting only of collagen or collagen and vitamin K.E.F. The main: the purpose of these cosmetics is to compensate for the loss of soluble collagen during artificial and natural aging of the skin man. In practice, this is achieved by direct penetration of the cosmetic product with the skin and, at best, assimilation of the amino acid skin by the principle of surface osmosis of human skin. These cosmetics and the principle of their absorption and assimilation by the skin lead to a partial intake of embedded soluble collagen and, ultimately, to an improvement in the elasticity and appearance of the skin, without detecting additional fibrillation. In addition, the assimilation process is very slow and depends on the degree of removal of the oily membrane, and constricting pores.
    The objective of the invention is the creation of a cosmetic product and a method for its production, containing a combination of collagen and pyridoxal-5-phosphate2, in which collagen is a donor of amino acids that pyridoxal-5t phosphate includes in the exchange of connective tissue, resulting in elasticity, appearance and fibrillation of the skin improves; it is much more significant in comparison with cosmetics only on a collagen base.
    The problem is solved by creating a cosmetic product containing, as an active component, a 0.6-0.8% solution of water-soluble collagen, in which from 0.6 to 1% pyridoxal-5-phosphate is embedded.
    A method of obtaining a cosmetic product consists in the fact that water-soluble collagen is mechanically crushed in a jet colloid mill to 10% of microcrystalline particles, filtered through a mixture to eliminate macromolecules and mixed with pyridoxal-5-phosphate.
    Mixing is as follows.
    A 0.6-0.8% aqueous solution of water-soluble collagen is placed in a glass reactor equipped with a water jacket and a stirrer of 40-5.0 rpm. The temperature of the solution is 20 ° C (GS, the stirrer is turned on, and nipagin, sorbic acid and 96% ethanol are subsequently added to the reactor. After 15-20 minutes, the stirrer is stopped. Pyridoxal-5-phosphate is added in portions without stirring, after which 5 the irradiated product is poured into dark or opaque vessels, storage temperature 0-25 ° C.
    Advantages of the cosmetic product: quick incorporation of water-10 rim collagen into the exchange of connective tissue through pyridoxal-5phosphate, assimilation of a significant part of the embedded water-soluble collagen by the skin. The effect is expressed organoleptically quickly (improved turgur, ι appearance and uniformity). Method does not need special equipment and is not difficult .. :
    EXAMPLES EXAMPLE 1 Preparation piridok-'jq sal-5-phosphate from pyridoxamine (vitamin B derivative).
    2.5 kg of pyridoxamine dihydrochlorate is loaded into a glass reactor with a capacity of ью uL equipped with a coil for .jg electric heating and a stirrer of 40-50 rpm; a mixture of 4 l of phosphoric acid and 500 g of bisphosphoric pentoxide is introduced. Turn on the stirrer. The mixture is heated to 60-70 ° C ”with continuous stirring · · · for 1 hour. After this, the mixture is cooled to 20-25 ° C and 400 g of manganese dioxide are added to it. The stirrer is turned on again, the temperature is set at 30-35 ° C and the reaction is continued for 30 minutes with continuous stirring 3 '. After cooling the mixture, 300 g of activated carbon are loaded into the reactor to adsorb the cations in solution. Then the mixture is filtered through an ordinary filter. Osa-40 dock is discarded, and the filtrate is treated with 200 ml of acetone with stirring, after which pyridoxal-5-phosphate precipitates. The liquid phase is removed and the precipitate is dried at room temperature <5 re.
    Example 2. Obtaining a collagen component.
    L of a one percent solution of soluble collagen obtained by cor- ed according to copyright certificate No. 29435 is passed twice through a jet colloidal mill (type. Stefan, Corum), and then filtered on a filter press with charges (blends FROM). The final product · is an almost transparent slightly opalescent liquid containing a 0.6-0.8% solution of water-soluble collagen.
    PRI me R 3. Obtaining a cosmetic product collagen-pyridoxal-5-phosphate with 0.6-0.8% water-soluble, collagen is loaded into a glass reactor with a capacity of 5 l, equipped with a water jacket for cooling and a stirrer 40- 50 rpm The temperature of the solution is 20-25 ° C. The mixer is turned on and 6 g of nipagin, 8. g of sorbic acid and 120 mp 96% ethanol are successively introduced into the reactor. After 20 minutes, the stirrer is stopped. 12 g of pyridoxal-5-phosphate are added in portions without stirring, after which the resulting product is poured into dark or opaque vessels. Store at a temperature of 0-20 ° C.
    权利要求:
    Claims (2)
    [1]
      . one . The invention concerns a collagen cosmetic based on a collagen and a method for its preparation. Cosmetic products are known that consist only of collagen or collagen and vitamin K. Е.Р.рсновной: the purpose of these cosmetics is to compensate for the loss of soluble collagen during artificial and natural aging of human skin. Practically, this is achieved by direct penetration of the cosmetic by the skin and, at best, by assimilation of amino acids by the skin by the principle of surface oemosis. These cosmetics and the principle of their introduction and absorption by the skin lead to a partial intake of the nested soluble gene call and, in the end, to improve, above all, the elasticity and appearance of the skin without detecting additional fibrillation. In addition, the assimilation process is very slow and depends on the degree of removal of the oily shell,. tightening pores. The objective of the invention is the creation of a cosmetic and a method for its preparation containing a combination of collagen and pyridoxal-5-phosphate, in which the collagen is dono-. rum of amino acids, some of which pyridoxal-5g phosphate includes in the connective: tissue exchange, as a result of which the elasticity, appearance and fibril of the skin are improved much more significantly in comparison with ic cosmetics. only on the collagen base. .. The problem is solved by creating a cosmetic containing as a active ingredient a 0.6-0.8% solution of water-soluble collagen, in which 0.6 to 1% pyridoxal-5-phosphate is enclosed. The method for producing a cosmetic is that water-soluble collagen is mechanically crushed in a spraying colloid mill to 10% of microcrystalline particles, filtered through a mixture to remove macromolecules, and mixed with pyridoxal-5-phosphate. Mixing is performed as follows. A 0.6-0.8% aqueous solution of water-soluble collagen is placed in a glass reactor equipped with a water jacket and a 40-5.0 rpm sack. The temperature of the solution is 20-3 (gC, the stirrer is turned on and nipagin, sorbic acid and 96% ethyl alcohol are successively added to the reactor. After 15-20 minutes, the stirrer is stopped. Pyridoxal-5-phosphate is added in portions without stirring, after which The resulting product is poured into dark or opaque vessels. Temporary temperature Advantages of the cosmetic: fast incorporation of water-soluble collagen in the exchange of connective tissue through pyridoxal-5 phosphate, absorption of a significant part of the enclosed water-soluble collage on the skin. The effect is expressed organoleptically quickly (improved turgur, its appearance and uniformity) The method does not require special equipment and is easy-to-use. Example: Preparation of pyridoxal-5-phosphate from pyridoxamine (vitamin Dg Bg vitamin.) 2.5 kg-pyridoxacamin-dihydroxlope , a are loaded into a glass reactor with a capacity of UL, equipped with a coil for an electric motor and a 40-50 OB / min stirrer, a mixture of 4 liters of phosphoric acid and 500 grams of biphosphoric pentoxide is introduced. Turn on the stirrer. The mixture is heated. ID 60-70 Ci with continuous mixing-. Research institutes within 1 hour. After that, the mixture is cooled to 20-25 ° and 400 g of manganese dioxide is added to it. The mixer is switched on again and the temperature is set at 30-35 ° C and the reaction is continued for 30 minutes with continuous stirring. After cooling the mixture, 300 g of active carbon is charged to the reactor to adsorb the cations in solution. Then the mixture is filtered through an ordinary filter. The precipitate is discarded, and the filtrate is treated with 200 ml of acetone with stirring, after which pyridoxal-5-phosphate precipitates. The liquid phase is withdrawn, and the precipitate is dried at room temperature. Example 2: Preparation of the collagen component. 5 liters of a one-percent solution of diluted collagen obtained according to the author's certificate No. 29435 are passed twice through a stringy colloid mill (typ. Stefan, Koruma), and then filtered on a filter press with mixtures (charge No. 3). The final product is an almost clear, slightly opalescent liquid containing a 0.6-0.8% solution of water-soluble collagen. Example 3. Collagen-pyridoxal-5-phosphate 4 cosmetic preparation 2 l O, 6-0,8% water-soluble collagen is loaded into a 5 l glass reactor equipped with a water jacket for cooling and a 40-50 stirrer rpm Solution temperature is 20-25 o. The mixer is turned on and 6 g of nipagin, 8. g of sorbic acid and 120 ml of 96% ethanol are sequentially introduced into the reactor. After 20 min, the stirrer is stopped. 12 g of pyridoxy-5-phosphate are introduced in portions without stirring, after which the resulting product is poured into dark or opaque vessels. Store at temperature. Claim 1. Cosmetic based on collagen, characterized by That under the active component contains a mixture of 0.6-0.8% aqueous solution of collagen and from 0.6 to 1% pyridoxal-5-phosphate.
    [2]
    2. A method for producing a cosmetic according to claim I, characterized in that the water-soluble collagen is mechanically crushed in a spraying colloid mill to 10% microcrystalline particles, filtered through a mixture to eliminate macromolecules, and mixed with pyridoxal-5-phosphate. Recognized as an invention according to the results of the examination carried out by the Office for Invention of the People’s Republic of Bulgaria i
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    同族专利:
    公开号 | 公开日
    FR2393571A1|1979-01-05|
    JPS5417135A|1979-02-08|
    US4228153A|1980-10-14|
    FR2393571B1|1983-01-28|
    AT372606B|1983-10-25|
    BG25398A1|1978-10-10|
    CH637824A5|1983-08-31|
    ATA421778A|1983-03-15|
    DE2825386A1|1978-12-21|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US3839590A|1970-02-02|1974-10-01|Avicon Inc|Cosmetic compositions containing microcrystalline collagen,a water-insoluble,ionizable,partial salt of collagen|
    US3991184A|1973-10-05|1976-11-09|Martin Kludas|Agent for the care of skin|
    US3941722A|1974-05-06|1976-03-02|Chattem Drug & Chemical Company|Bath beads containing allantoin|
    US3949073A|1974-11-18|1976-04-06|The Board Of Trustees Of Leland Stanford Junior University|Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution|
    FR2309210B1|1975-01-27|1977-11-18|Minault Honore|
    DE2517452C3|1975-04-19|1978-11-02|Fa. Carl Freudenberg, 6940 Weinheim|Collagen foil for cosmetic use|JPH0456004B2|1983-10-20|1992-09-07|Shiseido Co Ltd|
    US5036056A|1987-07-08|1991-07-30|Martin Kludas|Methods for treating damaged corneal, uterine, or cartilage tissue|
    US5055298A|1987-12-01|1991-10-08|Chemisches Laboratorium Dr. Kurt Richter Gmbh|Cosmetic composition comprising an extracellular connective tissue matrix|
    AU649634B2|1989-10-10|1994-06-02|Gillette Company, The|Amino acid beta-lyase enzyme inhibitors as deodorants|
    US6451326B2|1996-05-02|2002-09-17|Burt D. Ensley|Cosmetic compositions|
    US7235249B2|2002-03-28|2007-06-26|The Procter & Gamble Company|Methods for regulating the condition of mammalian keratinous tissue via topical application of vitamin B6 compositions|
    US9439940B2|2011-07-19|2016-09-13|Neville Pharmaceutical, Inc.|Topical transdermal method for delivering nutrients through the skin for expeditied wound healing and skin rejuvenation|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    BG7700036563A|BG25398A1|1977-06-10|1977-06-10|A cosmetic means on the colagen base and a method of its obtaining|
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