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    • 专利摘要:

    公开号:SU900813A3
    申请号:SU782632645
    申请日:1978-07-10
    公开日:1982-01-23
    发明作者:Брейе Эмиль；Буске Андре
    申请人:Паркор (Фирма)；
    IPC主号:
    专利说明:

    The invention relates to a method for producing thienopyridine derivatives of the general formula
    where Rj is a hydrogen atom, benzyl, in certain cases substituted by the · in the ortho position by a halogen atom,
    R ^ is a hydrogen atom, (C, -C0 -alkyl, (C 1 -Cj) -alkoxycarbonyl, phenyl or thienyl, which have valuable pharmacological properties.
    Known two-stage method for producing derivatives of thienopyridine General formula 20
    where R ^ is alkyl, aryl or aralkyl;
    Rj and Rj are a hydrogen atom, lower alkyl, a heterocyclic radical, or their salts, which consists in the fact that in the first stage, the | 3-thienyl-2-ethylamine derivative is reacted with formaldehyde in an aqueous medium, water is carefully removed from the obtained intermediate product, and then in the second stage it is cyclized by the action of hydrogen chloride in anhydrous aprotic solvent, ω
    The disadvantage of this method is the need for the process in two stages.
    The purpose of the invention is the simplification of process technology and the expansion of the range of target products.
    This goal is achieved by the method of obtaining derivatives | thienopyridine of General formula I, which is that the derivative | 3-thienyl-2-ethylamine of the general formula (") 5 where R, has the indicated meanings, is reacted with a compound of the general formula
    X-CH-U
    I n
    where has the specified values,
    X is a halogen atom or alkoxy (III)
    a group optionally substituted with a chlorine atom; 15 1 y is lower alkoxy or lower thioalkyl, optionally substituted with a chlorine atom, or a -DCR group, о 20 where R is lower alkyl, or x and y form hexahydro-B- with the carbon atom to which they are bonded a triazine or trioxane ring; or a residue of urotropine, in an inert organic solvent at 0-150 ° C, in an anhydrous medium, and the target product is isolated.
    The reaction is preferably carried out at a temperature from room temperature to the boiling point of the most volatile component in an aprotic polar solvent (dimethylformamide, dimethyl sulfoxide, hexamethyl 35 phosphorotriamide), benzene, chlorinated hydrocarbon or in a simple ether.
    In addition, preferably an inert 40 organic solvent contains a mineral or organic acid such as carboxylic or sulfonic, for example hydrochloric or methanesulfonic acid.
    Thus preferably 43 cal organic solvent is selected so that the hydrobromide of general formula I is insoluble.
    In addition, a compound of the general formula III is taken for the reaction in an amount of from stoichiometric to 50% molar excess, relative to the compound of the general formula II.
    Example 1. Preparation of 5- (2-chlorobenzyl) -4,5,6,7-tet-55 hydrohydro [3,2-c] thienopyridine hydrochloride.
    To a solution of 50.8 g (0.2 mol) of N- (2-chlorobenzyl) -2-thienyl-2-ethylamine in 70 ml of dimethylformamide heated to 60 ° C, 22.7 g (0, 24 mol) of chloromethyl methyl ether.
    The temperature of the reaction medium is maintained at 60 ° C. over the entire period of addition by cooling with water. 30 minutes after the addition of chloromethyl methyl ether was completed, the reaction medium was cooled to 20 ° C. The desired reaction product precipitated is filtered and washed twice with 70 cm ^ of acetone. Get 45.1. g of the total compound, yield 7 5%.
    Processing of the filtrates makes it possible to extract another 9 g of the final compound (90% yield). 190 ° C.
    Example 2. Obtaining hydrochloride 5- (2-chlorobenzyl) -4-ethoxycarbonyl-4,5,6,7-tetrahydro [3,2-c] thienopyridine.
    A solution of 25.1 g (0.1 mol) of N- (2-chlorobenzyl) -2- (2-thienyl) ethylamine in 30 ml of dimethylformamide is introduced into a 250 ml three-necked flask. Then, 18.3 g (0.11 mol) of chloro-2-ethoxy-2-ethyl acetate are added over 6 minutes and heated at 80 ° C for 4 hours. The desired product begins to precipitate. After cooling the medium, the product is filtered and crystallized three times with 20 ml of acetone. Receive
    20.5 g of compound, 55% yield.
    Processing filtrates allows you to get an additional 10 g of crude product with so pl. 156 ° C. From the crude product, pure is obtained by recrystallization from a mixture of ethanol-isopropyl ether (total yield 81, 8%).
    Example 3. Preparation of 5- (2-chlorobenzyl) -4- (2-thienyl) -4,5,6,7-tetrahydro- (3,2-c) thienopyridine hydrochloride.
    a) Preparation of (2-thienyl) chloromethyl ether
    While stirring, 112 g (1 mol) of (2-thienyl) carboxaldehyde, 50 g (1.55 mol) of methanol, 125 ml of methylene chloride and 150 g of sodium sulfate are loaded into the flask. The reaction medium is cooled to -35 ° C and a stream of gaseous dry hydrogen chloride is passed to saturation, preventing the temperature from rising above -20 ° C. After the evolution of hydrogen chloride bubbles ceased, the reaction medium was left under stirring at a temperature of −20 ° C. for 2 hours. Methylene chloride was then distilled off at −20 ° C. to give crude (2-thienyl) chloromethyl ether.
    c) Preparation of the final compound., N- (2-chlorobenzide) -2- (2-thienyl) ethylamine acts on the obtained ester according to the procedure described in Example 1 to obtain the desired compound. Mp base 109 ° C.
    Examples 4 and 5. By the method of example 1 receive hydrochloride 5- (2-chlorobenzyl) -4-phenyl-4,5,6,7-tetrahydro- (3,2-c) thienopyridine (mp 95 ° C base ) and 5- (2-chlorobenzyl) -4-isopropyl-4,5,6,7-tetrahydro- (3,2-s) thienopyridine hydrochloride (mp 172 ° C), starting from N- (2 -chlorobenzyl) -2 -. (2-thienyl) ethylamine and, respectively, C-chlorobenzylmethyl ether and 1-chloro-1-ethoxy-2-methylpropane.
    Example 6. Obtaining hydrochloride 4, 5,6, 7-tetrahydro-¢ 3.2-s.) 900813
    b) Preparation of the final compound. To a solution of 52 g (0.2 mol) '- (2-chlorobenzyl) -2- (2-thienyl) ethylamine. in 60 ml of dimethyl sulfoxide, heated to 60 ° C, 51 g (0.3 mol) of the obtained crude chloromethyl methyl thioether are added over 30 minutes. The temperature of the reaction medium gradually rises and is maintained in the range of 8 ° -85 ° C during the entire addition step by cooling with water. Upon completion of the addition of chloromethyl methyl thioether, the reaction medium is cooled to 6 ° C. The required product precipitates. After filtering and washing twice with 70 ml of 5 acetone, 44.1 g of the final compound are obtained. Yield 73.5%.
    Processing of the filtrates allows to extract an additional 10 g of the final compound with so pl. 190 ° C (90% yield). The resulting crude product contains 1-2% impurities and can be obtained pure for analytienopyridine. 25
    To a solution of 12.7 g (0.1 mol) of 2- (2-thienyl) ethylamine in 20 ml of dimethylformamide, heated to 55 ° C, 8.05 g (0.1 mol) of chloromethyl methyl ether diluted in 10 minutes was added 10 ml of dimethylformamide. After addition of chloromethyl ether, the reaction medium was maintained at 70 ° C for 2 hours, then cooled to ambient temperature. The precipitated product is washed with acetone. Obtain 5.5 g of hydrochloride of the final compound with so pl. 225 ° C. Yield 31%.
    Example 7. Preparation of 5- (2-chlorobenzyl) -4,5,6,7-tetrahydro-3,2-e) thienopyridine hydrochloride.
    a) Preparation of chloromethyl thioether.
    Into a 1-liter three-necked flask, 274 g (2.3 mol) of thionyl chloride and 400 ml of methylene chloride are charged. It is refluxed to 41 ° C. and 156 g of dimethyl sulfoxide are slowly added. During the entire period of addition, the emission of SOj and HC1 is strongly observed. At the end of the addition of dimethyl sulfoxide, a nitrogen stream is passed to remove dissolved hydrogen chloride. The reaction mass ¢ 333 g) is subjected to cyclization. The result is 56.77% chloromethyl methyl thioether and 33% methylene chloride.
    after by recrystallization from ethanol.
    Example 8. Preparation of 5- (2-chlorobenzyl) -4.5, .6,7-tetrahydro- (3,2-e) thienopyridine hydrochloride.
    66.5 g (0.44 mol) of triacetyl chloromethyl sulphate is reacted with heating for 3 hours with a solution of 103 g (0.4 mol) of N '- (2-chlorobenzyl) -2- (2-thienyl) ethyl in 300 ml of dimethyl sulfoxide and get the final compound with a yield of 51%.
    Example 9. Obtaining hydrochloride 5- (2-chlorobenzyl) -4,5,6,7-tetrahydro- (3,2-th) thienopyridine.
    0.25 mol of gaseous hydrogen chloride is dissolved in 42 ml of dimethylformamide and heated to 40 ° C. A mixture of 25.15 g (0.1 mol) of N- (2-chlorobenzyl) -2- (2-thienyl) ethylamine and 15.3 g (.0.033 mol) of S-hexahydrothiazine o is added to this solution over 45 2 min. -chlorobenzylamine. The reaction is exothermic, so the reaction mass should be cooled with water to maintain the temperature below 70 ° C. The contents of the flask are incubated for 30 minutes with stirring, then cooled. The desired product precipitated was filtered and washed with N 55 twice with acetone. Yield 17.3 g.
    Processing the filtrates allows you to extract an additional 10 g of the desired product (total yield 90%).
    90081 3
    Examples 10-12. Preparation of 5 ~ (2-chlorobenzyl) -4,5,6,7-tetrahydro- (3,2-s) thienopyridine hydrochloride.
    By the procedure of Example 9, by replacing S-hexahydrotriazine with o-chlorobenzylamine with S-hexahydrotriazine n-butylamine (yield about 90%), urotropine (yield 60%) and paraformaldehyde (yield 83%), the resulting compound is obtained.
    Example 13. Obtaining hydrochloride 4,5,6,7-tetrahydro- (3,2-s) thienopyridine.
    0.45 mol of hydrogen chloride gas is dissolved in 73 ml of dimethylformamide heated to 45 ° C and a mixture of 17 g (0.2 mol) of S-hexahydrotriazine n-butylamine and g 2- (2-thienyl) is added over the course of a minute ethylamine. During the addition, the temperature of the reaction medium was maintained at 45 ° C. using a cold water bath. At the end of the addition, the final compound precipitates and is filtered. Yield 22.16 g (65%). ' 1
    Example 14. Obtaining hydrochloride 5- (2-chlorobenzyl) -4,5,6,7-tetrahydro- (3,2-c) thienopyridine.
    To a suspension of 2.25 g (0.075 mol) of paraformaldehyde in 20 ml of dimethylformamide was added 9.61 g (0.1 mol) of methanesulfonic acid. At a temperature of the reaction medium of 72 ° C, 13 g (0.05 mol) of N- (2-chloro b-benzyl) -2- (2-thienyl) ethylamine dissolved in 5 ml of dimethylformamide are added over 2 minutes. The temperature of the reaction medium reaches 90 ° C. The medium is cooled to 20 * C and poured into 50 ml of 4 N. a solution of soda, extracted with 30 ml, and then 20 ml of methylene chloride. The organic phases are combined, dried over sodium sulfate and the solvent is distilled off. An oil is obtained which is dissolved in 30 ml of ethanol containing 0.15 mol of hydrogen chloride gas in a solution. After partial distillation of ethanol, the resulting compound precipitates. It is filtered, washed with acetone and dried. Yield 11.35 g (75.6%).
    The invention allows in one step to obtain thienopyridines substituted in the fourth position of the ring.
    权利要求:
    Claims (7)
    [1]
    3 is that the derivative of | 5-thienyl-2-ethylamine of the general formula X Y — CH j CH, where R is as defined, is reacted with a compound of the general formula X-CH-Y I Kg where R, has the indicated values, a halogen atom. or an alkoxy group, where appropriate substituted with a chlorine atom; y is lower alkoxy or lower thioalkyl, optionally substituted with chlorine, or the -DCR group, where R is lower alkyl, or X and y form carbon with which carbon is attached, hexahydro-5-triazine or trioxane ring; or the residue urotropin.in, in an inert organic solvent at ~ 150 ° C, in an anhydrous medium, and the whole product is removed. In this case, the reaction is preferably carried out at a temperature ranging from room temperature to the boiling point of the most volatile component in an aprotic polar solvent (dimethylformamide, dimethyl sulfoxide, hexamethylphosphorotriamide), benzene, a chlorinated hydrocarbon or in a light ether. In addition, preferably, the inertial organic solvent contains a mineral acid or an organic acid, such as hydrochloric acid or sulfonic acid, for example hydrochloric acid or methanesulfonic acid. In this case, preferably, the organic solvent is chosen such that the hydrobromide compound of the general form is not soluble. In addition, the compound of the general formula W is taken for a reaction in the amount of stoichiometric to 50% molar excess with respect to the compound of general formula 11. Example 1. Semi-chlorine 5- (2-chlorobenyl) -4 , 5,6,7-tetrahydro-3,2-th thienopyridine. To a solution of 50.8 g (0.2 mol) of N- (2-chlorobenzyl) -2-thienyl-2-ethylamine in 70 ml of dimethylformamide heated to 60 ° C, 22.7 g (0, 24 mol) chloromethyl methyl ether. The temperature of the reaction medium is maintained at 60 ° C for the entire period of addition by cooling with water. 30 minutes after the end of the addition of chloromethyl methyl ether, the reaction medium is cooled to. The desired reaction product precipitated in the precipitate is filtered and washed twice with 70 cm of acetone. Get 45.1. g of the final compound, 75% yield. Processing the filtrates allows the recovery of another g of the final compound (yield 90%). Mp. 190 ° C, Example
    [2]
    2. Preparation of 5- (2-chlorobenzyl) -4-ethoxycarbonyl-4, 5,6,7-tetrahydro-3, 2-C1-thienopyridine hydrochloride. In a three-neck K 250 flask with a capacity of 250 ml, a solution of 25.1 g (0.1 mol) of M- (2-chlorobenyl) -2- (2-thienyl) ethylamine in 30 ml of dimethylformamide is introduced. Then, 18.3 g (O, II mol) of chloro-2-ethoxy-2-ethyl acetate is added over 6 minutes and heated for 4 hours under SOC. The desired product begins to precipitate. After cooling the medium, the product is filtered and crystallized three times with 20 ml of acetone. 20.5 g of compound are obtained, yield 55%. Processing the filtrates yields an additional 10 g of the crude product with a mp. . From the crude product, a pure is obtained by recrystallization from ethanol-iso-crop ether mixture (total yield 81.8%). Example Preparation of 5- (2-chlorobenzyl) -4- (2-thienyl) -4,5,6, 7-tetrahydro- (3, 2th) thienopyridine hydrochloride. a) Preparation of (2-thienyl) chloromethyl ether 112 g (1 mol) (2-thienyl) carboxaldehyde, 50 g (1.55 mol) of methanol, 125 ml of methylene chloride and 150 g of sodium sulfate are charged to the flask with stirring. The reaction medium is cooled to -35 ° C and a flow of dry hydrogen chloride gas is passed through to saturation, preventing the temperature from rising above -20 ° C. After cessation of the release of hydrogen chloride bubbles, the reaction medium is left under stirring 5 at -20 ° C for 2 hours. methylene chloride is distilled off at -20 ° C and the crude (2-thienyl) chloro methyl ester is obtained. c) Preparation of the final compound The resulting ester is treated with N- (2-chlorobenzyl) -2- (2-thienyl) ethyl) according to the procedure of Example 1 in order to obtain the desired compound. M.p. bases. . Examples 4 and 5. According to the procedures of Example 1, 5- (2-chlorobenzyl) -4-phenyl-A, 5,6,7-tetrahydro {3, 2-e) thienopyridine (t, base pl. 95 ° C) and hydrochloride 5- are obtained. (2-Chlorobenzyl) -4-isopropyl-D, 5,6,7-tetrahydro-C3, 2-e) thienopyridine (t, mp. Base 172 ° C), starting from N- (2-chlorobenzyl) -2- . (2-thienyl) ethylamine and, respectively, C-chlorobenzyl methyl ester and 1-chloro-1-ethoxy-2-methylpropane. Example 6. Preparation of 4, 5.6, 7-tetrahydro- (3, 2-nd) thienopyridine hporohydrate. To a solution of 12.7 g (0.1 mol) of 2- (2-thienyl) ethylamine in 20 ml of dimethylformamide, preheated before, is added over 10 min. 8.05 g (0.1 mol) of chloromethyl methyl ether diluted with JO ml of dimethylformamide . After chloromethyl ether is added, the reaction medium is maintained for 2 hours at 70 ° C, then cooled to ambient temperature. The precipitated product is washed with acetone. 5.5 g of the hydrochloride of the final compound are obtained with a mp. Exit 31%. Example 7. Preparation of 5- (2-chlorobenzyl) -4,5,6,7-tetrahydro- (3,2-c) thienopyridine hydrochloride. a) Preparation of chloromethyl thioester In a three-neck flask with a capacity of 1 l load 274 g (2.3 mol) of thionyl chloride and 400 ml of methylene chloride. The mixture is heated under reflux to 41 seconds and 156 g of dimethyl sulfoxide is slowly added. During the entire period of addition, the gases SOj and HC1 are strongly evolved. At the end of the addition of dimethyl sulfide, a stream of nitrogen is passed through with a chain to remove dissolved hydrogen chloride. The reaction mass (333 g) is subjected to cyclization. As a result, 56.77% of chloromethyl methyl thioether and 33% of methylene chloride are obtained. 1,136 b) Obtaining the final compound. To a solution of 52 g (0.2 mol) of N- (2-chlorobenzyl) -2- (2-thienyl) ethylamine in 60 ml of dimethyl sulfoxide, heated to 60 ° C, 51 g (0.3 mol) of the resulting crude chloromethyl methyl thioether. The temperature of the reaction medium gradually rises, and it is maintained in the range of 80-85 ° C throughout the addition stage by cooling with water. At the end of the addition of the chloromethyl methyl thioester, the reaction medium is cooled to 6 ° C. The desired product precipitates. After filtering and rinsing twice with 70 ml of acetone, 44.1 g of the final compound are obtained. The yield is 73.5%. The treatment of the filtrates makes it possible to extract an additional 0 g of the final compound with m.p. 190 ° C (yield 90%). The crude product obtained contains 1-2% impurities and can be obtained pure, for analysis by recrystallization from ethanol. Example 8. Preparation of 5- (2-chlorobenzyl) -4,5, .6, 7-tetrahydro- (3, 2-e) thienopyridine hydrochloride. 66.5 g (0.44 mol) of triacetylchloromethyl with a solution of 103 g (0.4 mol) of N- (2-chlorobenzyl) -2- (2-thienyl) ethylamine are brought into interaction with the solution during 3 hours. in 300 ml of dimethylsulfoide and get the final compound e yield 51%. Example 9. Preparation of 5- (2-chlorobenzyl) -4,5,6, 7,7-tetrahydro (3,2-e) thienopyridine hydrochloride. 0.25 mol of gaseous hydrogen chloride is dissolved in 42 ml of dimethylformamide and heated to 40 ° C. A mixture of 25.15 g (0.1 mol) of N- (2-chlorobenzyl) -2- (2-thienyl) ethylamine and 15.3 g (0.033 mol) of S-hexylhydrothiazine o- chlorobenzylamine. The reaction is exothermic, therefore, the reaction mass should be cooled with water to maintain the temperature below 70 ° C. The contents of the flask incubated for 30 minutes with stirring, then cooled. The desired product precipitated is filtered and washed twice with acetone. Yield 17.3 g. Treatment of the filtrates allows an additional 10 g of the desired product to be recovered (about 90% yield). 79008 Examples 10-12. Preparation of 5- (2-chlorobenzyl) -4,5,6,7-tetrahndro- (3,2-e) thienopyridmyl hydrochloride. According to the procedure of Example 9, replacing S-hexahydrotriazine o-chlorobenzyl-5 amine with S-hexahydrotriazine n-butylamine (yield about 90%), methenamine (yield 60%) and paraformaldehyde (yield 83Z) receive the final compound. ID Example 13. Preparation of hydrochloride 4,5,6,7-tetra-hydroxy- (3,2-с) thienopyridium. In 73 ml of dimethylformamide, heated until then, 0.45 mol of hydrogen chloride gas is dissolved and a mixture of 17 g (0.2 mol) of S-hexahydrotriazine n-butylamine and jo 26g 2- (2 -Tiensh1) ethylamine. During the addition, the temperature of the reaction medium was maintained at 45 ° C using a cold water bath. When i completes the addition, the final compound precipitates and is filtered. Yield 22.16 g (65%). Example 14. Preparation of 5- (2-chlorobenzyl) -4,5,6,7-jO-tetrahydro- (H, 2-e) tnopyridine hydrochloride. To a suspension of 2.25 g (0.075 mol) of paraformaldehyde in 20 ml of dimethylformamide, 9.61 g (0.1 mol) of 35 methanesulfonic acid are added. At a temperature of the reaction medium of 72 ° C, 13 g (0.05 mol) of N- (2-chlorbeisyl) -2- (2-thienyl). Ethylamine dissolved in 5 ml of dimethyl form is added over 2 minutes ;. 40 amide. The temperature of the reaction medium reaches 90 ° C. The medium is cooled before and poured into 50 ml of 4N soda solution, extracted with 30 ml and then 20 ml of methylene chloride. The organic phases are combined, dried over sodium sulfate and the solvent is distilled off. An oil is obtained which is dissolved in 30 ml of ethanol containing 5 moles of gaseous hydrogen chloride in a solution of 0%. After partial distillation of ethanol, the final compound precipitates. It is filtered, washed with acetone and dried. Yield 11.35 g (75.6%). The invention allows in one stage to obtain thienopyridines, substituted in the fourth position of the ring. 13 1 where from on to what is in a to-which is where it is connected where it is intact and at the feet and on the feet of the floor 8 Claim of the invention I. The method for producing the opyridine derivatives of the general formula IR is a hydrogen atom, benzyl, in known cases substituted in ortho-position by a halogen atom; Rj is an atom of hydrogen, (C; (- Cc) -alkyl, (C | -Cj) -alkoxycarbonyl, .phenyl or thienyl, derived from ji-thienyl-2-ethylamino differently, in order to simplify ess technology and expand the range , the f-thienyl-2lamine derivative of the target products using the compound of the general formula AND CHi-CH2-NH-R R. has the indicated values, and is subjected to interaction with the formula P1 X-CH-V RJ has the indicated values; X is a halogen atom or an alkoxy group substituted by a chlorine atom in the corresponding case; y is lower alkoxy or lower thioalkyl, in the corresponding case substituted by a chlorine atom or a group of the formula -OCR where R is low alkyl, I or X and y form with the carbon atom to which they are bound, hexahydro-5-triazine or trioxane ring or urotropine residue, an organic organic solvent C in an anhydrous medium and a product are separated. The method according to claim 1 is also distinguished by the fact that the reaction is carried out from room temperature to the boiling point of the reaction mass,
    [3]
    3. A method according to claim 1, characterized by the fact that an aprotic polar raster (dimethylformamide, dimethyl sulfoxide, hexamethylphosphorotriamide), benzene, a chlorinated hydrocarbon or a light ether is used as an inorganic solvent.
    [4]
    4. The method according to claim 3, characterized in that the inert organic solvent contains a mineral or organic acid such as carboxylic or sulfonic.
    [5]
    5. The method according to claim 4, I distinguish | U and with the fact that they use salt or methanesulfonic acid.
    [6]
    6. A method according to claim 3, characterized in that the organic solvent is chosen such that the hydrophilic acid 3. 10 Logides of compounds of general formula I are insoluble.
    [7]
    7. The method according to claim 1, I distinguish n and with that. that the compound by the formula P1 is taken for the reaction in an amount from stoichiometric to 50% molar excess with respect to the compound of general formula 11. Sources of information taken into account during examination I. French Patent No. 2319642, cl. C 07 D 495/02, published 04.77 (prototype).
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    同族专利:
    公开号 | 公开日
    RO74931A|1980-10-30|
    LU79823A1|1978-12-07|
    AU516506B2|1981-06-04|
    CA1113469A|1981-12-01|
    MX4884E|1982-12-02|
    IL54886A|1981-11-30|
    YU148278A|1982-08-31|
    FR2397417A1|1979-02-09|
    AT366691B|1982-04-26|
    HU181928B|1983-11-28|
    DK311078A|1979-01-13|
    EP0000453A1|1979-01-24|
    NZ187834A|1981-05-01|
    ZA783296B|1979-07-25|
    IL54886D0|1978-08-31|
    DK155285C|1989-07-24|
    US4174448A|1979-11-13|
    CH633013A5|1982-11-15|
    IT7850225D0|1978-07-10|
    YU41832B|1988-02-29|
    FI67852B|1985-02-28|
    JPS6339598B2|1988-08-05|
    JPS5419994A|1979-02-15|
    PL208318A1|1979-05-07|
    FI782044A|1979-01-13|
    PL115368B1|1981-03-31|
    IE46929B1|1983-11-02|
    BE868866A|1979-01-10|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    FR7721517A|FR2397417B1|1977-07-12|1977-07-12|
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