• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Method of measuring the oxygen association state of blood samples, which includes the steps of disposing a blood sample within a blood-receiving receptacle, providing a controlled atmosphere chamber, incubating the sample by placing it in the chamber and controlling said atmosphere therein so as to maintain the humidity, temperature, and carbon dioxide content of the atmosphere at substantially constant levels, and thereafter analyzing the sample by changing the concentration of oxygen in said chamber from time to time while observing the changes of oxygen association of the sample with respect to the concentration of oxygen within the chamber.
    公开号:SU862845A3
    申请号:SU772469958
    申请日:1977-04-12
    公开日:1981-09-07
    发明作者:Кисев Лутц
    申请人:Бакстер Травенол Лабораториз, Инк (Фирма)；
    IPC主号:
    专利说明:

    The invention of ± mosits to medical technology, namely, to analyzers of biological fluids. A device for analyzing biological fluids is known which contains a sealed chamber with an opening dp passing the light; flow, a cassette with a slot for placing the sample holder fluid, installed with the possibility of placing the sample holder opposite the opening in the chamber, means for regulating the atmosphere inside the chamber and means for recording changes in the light beam 11. However, this device does not provide for the preliminary exposure of the sample of the analyzed liquid in the atmosphere chambers to stabilize the specimen components. As a result, the individual components of the sample are lost and, as a result, the results are distorted. Nali object of the invention povshyu angshiza of accuracy due preincubation sample weatherp D camera. The goal is achieved by the fact that the device contains an additional cassette with sockets for accommodating at least two holders of a sample that can be installed parallel to the main cassette. In addition, the cassettes have a device for fixing their relative position. FIG. 1 shows a device for analyzing biological fluids in cross section; in fig. 2 is a cassette attachment unit, side view j in FIG. 3 - the same, front view; in fig. 4 - the same, inside view of the camera; in fig. 5 section A-A in FIG. four; in fig. 6, 7 main and optional cassettes; in fig. 8 - part of the chamber with the cassette's cassette unit, general view; in fig. 9 - clamp in cross section. The device contains a sealed chamber 1 with openings 2 and 3 for the light flow from source 4, with optical elements, in the form of lenses 5 and 6, installed in the openings 2, 3. Inside the camera 1 two cassettes 7 and 8 are installed slot accommodating holders 9, 10 of the liquid sample, which should occupy a position on the path of the luminous flux directed from the source 4 through the lenses 5 and 6 in the kara / hr. Inside the chamber are placed the means for regulating the atmosphere, which includes the fan C, the thermostat 12f meter 13 humidity input 14 oxygen and the inert gas input 15 Furthermore, the device comprises means for registering changes of the light beam, comprising a dispersive unit 16 fiptu l 17, 18, fotodetekto ry 19, 20, logarithmic amplifier 21, the registrar 22, an oxygen sensor 23, a detector 24, oxygen. The cassettes 7 and 8, provided with handles 25, 26, are installed in the chamber 1 with the possibility of movement parallel to each other and have devices for fixing their relative position. The fixation device for fixing many cassettes is made in the form of grooves 27, 28, which cooperate with spring-loaded ball retainers 29 and 30. Ball retainers 29, 30 are installed in the outer casing part 31 of the cassette attachment unit 31 which includes a wall 32 and grooves for spreading cassettes. The device works in the following way & shim .. Sample fluids are placed in holding bodies, and the necessary atmosphere inside the chamber is prepared. The sample holder is placed in the nest of the upper cassette T, which in turn is pushed into the chamber 1. After the end of the incubation period of the first specimen, the second specimen is inserted into the chamber. The specimen in the cassette B simultaneously moves the cassette 7 with the first specimen to the second position (inside) and turns on the optical axis of the translucent sietema for subsequent analysis of the biological fluid by means of recording changes in the light beam.
     f
      t
    t After completion of the analysis of the first sample and the end of the incubation period of the second sample, the upper cassette 7 with the first sample is removed from the chamber and recharged with an emergency sample, and the lower cassette 8 is moved to the position for angus production. At the same time, the upper cassette 7c with the next sample shifts into the chamber and occupies the first position for passing the incubation. Thus, the design of the device provides a preliminary exposure of the sample of biological fluid in the kgmer atmosphere, which increases the accuracy of the analysis. Formula of the Invention 1. A device for analyzing biological fluids, comprising a sealed chamber with an opening for passing a light beam, a cassette with a slot for accommodating a sample holder, liquid housing installed with the possibility of positioning the sample holder opposite the opening in the chamber, means for adjusting the atmosphere inside the chamber and means for recording changes of the light beam, so that, in order to improve the accuracy of the analysis due to the boiling temperature of the sample in the atmosphere, it contains A complementary cassette with slots for accommodating at least two sample holders, mounted with the possibility of repositioning parallel to the main cassette. 2. Device Ir p. 1, which is the fact that the cassettes have devices for fixing them in 3 different positions. Sources of information accepted during examination 1. Patent afflil 385478, cl. 23-230, published. 1§74 (prototype).
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    权利要求:
    Claims (2)
    [1]
    Claim
    1. A device for analyzing biological fluids, comprising a sealed chamber with an opening for the passage of a light beam, a cassette with a socket for accommodating a holder of a sample of liquid, mounted to position the sample holder opposite a hole in the camera, means for controlling the atmosphere inside the camera, and means for recording changes in the light beam , on the other hand, in order to increase the accuracy of the analysis due to preliminary exposure of the sample in the chamber atmosphere, it contains an additional cartridge sockets for placement of at least two sample holders mounted movably parallel to the main magazine.
    [2]
    2. The device according to π. 1, with the fact that the cartridges have devices for fixing their relative position.
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    同族专利:
    公开号 | 公开日
    FR2348491A1|1977-11-10|
    DE2715232A1|1977-10-20|
    IL51628D0|1977-05-31|
    GB1571317A|1980-07-16|
    US4014649A|1977-03-29|
    CA1059884A|1979-08-07|
    NL7703105A|1977-10-14|
    SE7704129L|1977-10-13|
    FR2348491B1|1983-02-11|
    NO771206L|1977-10-13|
    IT1077772B|1985-05-04|
    JPS52127295A|1977-10-25|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US3740320A|1971-01-25|1973-06-19|R Arthur|Apparatus and method for measuring the amount of gas absorbed or released by a substance|
    US3973915A|1971-04-09|1976-08-10|Instrumentation Laboratory, Inc.|Blood equilibrator|
    US3779708A|1972-01-31|1973-12-18|Us Navy|Method and means for determining oxyhemoglobin association and dissociation curves of whole blood or other liquids|
    FR2172665A5|1972-02-18|1973-09-28|Bergwerksverband Gmbh|
    US3854878A|1973-04-13|1974-12-17|Baxter Laboratories Inc|Method and apparatus for deriving oxygen association rate curves for blood samples|
    CA1044916A|1974-05-01|1978-12-26|Baxter Travenol Laboratories|Method and apparatus for deriving oxygen association curves|
    US3947122A|1974-12-16|1976-03-30|American Optical Corporation|Cuvette and stirrer for oximeter|USRE29769E|1973-04-13|1978-09-19|Baxter Travenol Laboratories, Inc.|Method and apparatus for deriving oxygen association rate curves for blood samples|
    US4120658A|1976-11-11|1978-10-17|Bruttig Stephen P|Method and apparatus for determination of dissociation of oxygen from blood|
    US4243322A|1978-04-24|1981-01-06|International Diagnostic Technology|Method and apparatus for photoluminescent detection and measurement|
    US4209300A|1978-09-25|1980-06-24|The United States Of America As Represented By The Department Of Health, Education And Welfare|Hemoglobin-oxygen equilibrium curve analyzer|
    DE3037962A1|1980-10-08|1982-05-13|Klaus Prof. Dr. Gersonde|METHOD AND DEVICE FOR DETERMINING THE OXYGEN BALANCE CURVES OF BLOOD OR. HAEMOGLOBIN SOLUTIONS|
    DE102006022854B4|2006-05-16|2008-04-17|Albert-Ludwig-Universität Freiburg|Implantable blood oxygen sensor|
    CN102087197B|2009-12-08|2014-06-18|龚维燕|Method of coaxial lighting in Coulter micro-hole of full-functional blood analyzer and analyzer therefor|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    US05/675,703|US4014649A|1976-04-12|1976-04-12|Method and apparatus for delivering blood oxygen association curve information|
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