• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    New proline derivatives and related compounds which have the general formula <IMAGE> are useful as angiotensin converting enzyme inhibitors.
    公开号:SU845775A3
    申请号:SU782595499
    申请日:1978-03-31
    公开日:1981-07-07
    发明作者:Энджел Ондетти Мигуэль；Вейн Кашмэн Дэвид
    申请人:Е.Р.Сквибб Энд Санз,Инк (Фирма)；
    IPC主号:
    专利说明:

    (54) METHOD FOR OBTAINING PROBLEM DERIVATIVES The invention relates to the field of production of new proline derivatives which can be used in medicine. In the literature, rnHjioKo describes the reaction of amines with acid chlorides. The aim of the invention is to develop, on the basis of a known method of producing new compounds with valuable pharmacological properties, the goal is achieved using the direct method of producing proline derivatives of the general formula CL gSN-CO-K R2-JO- &amp; JH2 dooH where R is hydrogen or methyl , RJ is Su-SL-alkyl, which consists in the fact that L-proline of the general formula HN1 is reacted with chloric acid anhydride of the general formula (1 H2 5-COOH where R has the indicated values, and the compound of the general formula O, C- (0-1GL. Where Ry has This is indicated by the action of the thio-acid of the general formula RJ-COSH. A racemate or one of the enantiomers can be used as starting compounds.When the synthesis material of the starting material is a racemic compound, the steroisomers obtained as a product can be separated from methods of chromatography or fractional crystallization. The final isomeric form is the L-isomer relative to carbon.
    权利要求:
    Claims (1)
    [1]
    Claim
    A method of obtaining proline derivatives of the general formula ' 1 . ABOUT
    R 2 - CO-fc-CHg-CH-CO-K - COOH, where R ^ is hydrogen or methyl, R ^ is C f -C / ralkyl, characterized in that
    L-proline of the general formula co.
    subjected to interaction with an acid chloride of the general formula ch 2 = (J-cooh, where R * is hydrogen or methyl, on the resulting compound of the general formula
    Sn 2 = CCO-'N-is soon, where. R ^ has the indicated meanings; they act with a thioacid of the general formula
    - COSH-
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    同族专利:
    公开号 | 公开日
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    US05/657,792|US4046889A|1976-02-13|1976-02-13|Azetidine-2-carboxylic acid derivatives|
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