• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    1462424 Methyl 3-(2-quinoxalinylmethylene)- carbazate-N<SP>1</SP>,N<SP>4</SP>-dioxide PFIZER Inc 15 March 1974 [10 April 1973] 11706/74 Heading C2C The title compound is prepared by reacting a nitrone, acetal, oxime, semicarbazone or thiosemicarbazone derivative of 2-formylquinoxaline-1,4-dioxide with NH 2 NHCO 2 Me or a hydrazone derived therefrom, provided that only said hydrazone may be used for reaction with an acetyl. Reference has been directed by the Comptroller to Specification 1,058,047.
    公开号:SU730302A3
    申请号:SU742013770
    申请日:1974-03-29
    公开日:1980-04-25
    发明作者:Фаубл Герман；Лакшмана Майлари Банавора
    申请人:Пфайзер Инк (Фирма)；
    IPC主号:
    专利说明:

    five
    This invention relates to a process for the preparation of methyl 3- (2-quinoxalinylmethylene) carbazate-N, N-dioxide, which has valuable physiological properties.
    A method of producing methyl 3- (2-quinoxalinylmethylene) carbazate-N, N-dioxide by reacting acetalquinoxalin-di-K - oxide with the corresponding carbazate at a temperature of 30-200 s in the presence of a strong acid catalyst in an inert solvent 1.
    The purpose of the invention is to simplify the process.
    This is achieved by a process for preparing methyl-3- (2-quinoxalinyl-methylene) Kap6a3aT-N, N-dioxide, zaklyuchayuschims that nitrones acetal, oksi.mnye, semicarbazono tiosemikserbazonovye or dioxide derivatives of 2-hinoksalinkarboksaldegida reacted with methyl carbazate, methyl -3- (lower) -alkylidene, cyclopentylidene, cyclohexylidene, or benzylidene-carbazates, provided that when the derivative is acetal, the carbaeate cannot be methyl carbazate, in an inert environment
    2
    solvent in the presence of a strong acid catalyst at a temperature of 30-200 C.
    As an inert solvent, a solvent can be used, which dissolves the reagents and does not have an undesirable effect on the reagents or on the obtained Nsje reaction products under conditions
    10 occurring in this process. At the most favorable are two types of solvents, which are organic acids, for example, acetic acid, and lower
    15 alcohols, and ethers, such as ethanol and ethyl acetate. Examples are acids: hydrochloric, hydrobromic, sulfuric, phosphoric, para-toluenesulfonic and trifluoroacetic.
    30 It is desirable to use an acid catalyst in an amount of from about 2 to 10% by weight of the total content of the reaction mixture. If a strong acid is used as a solvent for the reaction mixture of C2Si, for example, trifluoroacetic acid, it is not necessary to use an acid catalyst.
    It is necessary that in the reactionary
    30 mixtures present a little if
    权利要求:
    Claims (2)
    [1]
    Claim
    The method of producing methylr3- (2-quinoxalinylmethylene) to arbazate-N, N ** - dioxide based on 2-quinoxalium carboxaldehyde-N *, Ν 4 - dioxide derivative and carbazate, in an inert solvent in the presence of a strong acid catalyst at a temperature of 30-200 ° С, characterized in that, in order to simplify the process, as carboxaldehyde-N ^, Ν Μ
    [2]
    2-quinoxaline-dioxide derivative use nitron acetal, oxime, semicarbazone or thiosemicarbazone derivatives of 2-quinoxalinecarboxaldehyde dioxide and, as carbazate, methylcarbazate, methyl 3- (lower) -alkylidene, cyclopentylidene-cyclohexylidene or benzylidene carbazates, provided that when the specified derivative is acetal cannot be methyl carbazate.
    类似技术:
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    同族专利:
    公开号 | 公开日
    ZA742052B|1975-03-26|
    HU170050B|1977-03-28|
    MY7800014A|1978-12-31|
    DK140756C|1980-04-14|
    FR2225429A1|1974-11-08|
    YU83474A|1982-08-31|
    DK140756B|1979-11-12|
    CS212276B2|1982-03-26|
    NO141851B|1980-02-11|
    HK48877A|1977-09-30|
    IE39110B1|1978-08-02|
    JPS5030893A|1975-03-27|
    IT1056058B|1982-01-30|
    AU477279B2|1976-10-21|
    CH603599A5|1978-08-31|
    GB1462424A|1977-01-26|
    IL44434D0|1974-06-30|
    DD110875A5|1975-01-12|
    AU6682874A|1975-09-25|
    NL7404044A|1974-10-14|
    JPS5333596B2|1978-09-14|
    IL44434A|1977-08-31|
    SE407219B|1979-03-19|
    FR2225429B1|1977-06-24|
    NO141851C|1980-06-04|
    CA1018977A|1977-10-11|
    ES424803A1|1976-05-16|
    FI59405C|1981-08-10|
    AR210723A1|1977-09-15|
    FI59405B|1981-04-30|
    RO71311A|1981-08-30|
    PH11135A|1977-10-27|
    IE39110L|1974-10-10|
    NO741133L|1974-10-11|
    PL94963B1|1977-09-30|
    YU39151B|1984-06-30|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    JPS5135625Y2|1971-03-30|1976-09-02|
    JPS4984830U|1972-11-09|1974-07-23|
    JPS49100338U|1972-12-20|1974-08-29|
    IT1078991B|1977-05-26|1985-05-08|Erregierre Ind Chim Spa|PROCESS FOR THE PREPARATION OF THE HYDRAZONE CARBOMETHOXY, OF THE 2-FORMYLKINOXALINE-1,4-DI-N-OXIDE|
    JPS5487994U|1977-12-02|1979-06-21|
    DK141708C|1978-04-20|1980-10-20|Rasmussen K Holding A/S|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    US34980573A| true| 1973-04-10|1973-04-10|
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