专利摘要:
Prostaglandin derivatives corresponding to the general formula: <IMAGE> wherein R1 represents hydrogen, methyl or ethyl, R2, R3 and R4, which are the same or different, each represent hydrogen or methyl and R is selected from the groups consisting of: <IMAGE> <IMAGE> in which R5 represents hydrogen, methyl or ethyl, R6 represents methyl, ethyl or acetyl and R7 and R8, when they are different, each represent hydrogen or a branched- or straight-chain alkyl group having from 1 to 7 carbon atoms or R7 and R8, when they are identical, each represent hydrogen or a straight-chain alkyl group having from 1 to 3 carbon atoms with the provisos that:
公开号:SU715019A3
申请号:SU782595450
申请日:1978-03-30
公开日:1980-02-05
发明作者:Нантавонг Сули;Пижеруа Шарль;Эймар Пьер;Симиан Жак
申请人:Лябаз С.А. (Фирма);
IPC主号:
专利说明:

Nuclear Magnetic Resonance Spectrum (CDCla), b: 2.0 (CH3SO), 5 (), 7.4 (COOH).
权利要求:
Claims (1)
[1]
1. Carrer P. The course of organic chemistry. M., 1960, p. 262.
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同族专利:
公开号 | 公开日
NO149428B|1984-01-09|
DE2714129A1|1977-10-13|
BE852941A|1977-09-28|
IL49325A|1979-11-30|
PL107544B1|1980-02-29|
CH628032A5|1982-02-15|
CA1074804A|1980-04-01|
NO149428C|1984-04-18|
HU178040B|1982-02-28|
NO771134L|1977-10-03|
ES457385A1|1978-02-01|
JPS52142060A|1977-11-26|
DD130352A5|1978-03-22|
IL49325D0|1976-05-31|
PL107643B1|1980-02-29|
CH624101A5|1981-07-15|
PL108289B1|1980-03-31|
SE7703698L|1977-10-01|
NL7703503A|1977-10-04|
SE417603B|1981-03-30|
SU837321A3|1981-06-07|
FR2346332B1|1980-05-09|
FR2346332A1|1977-10-28|
IT1075373B|1985-04-22|
GB1574246A|1980-09-03|
SU676162A3|1979-07-25|
US4115401A|1978-09-19|
PL197005A1|1978-10-09|
引用文献:
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US3975399A|1974-08-06|1976-08-17|E. I. Du Pont De Nemours And Company|1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones|DK290079A|1978-07-11|1980-01-12|Glaxo Group Ltd|PROCEDURE FOR THE PREPARATION OF PROSTANOID COMPOUNDS|
US4320136A|1980-08-11|1982-03-16|E. I. Du Pont De Nemours And Company|8-Aza-16,16-difluoroprostanoids|
US4456613A|1982-12-27|1984-06-26|E. I. Du Pont De Nemours And Company|6-Keto- and 6-hydroxy-8-azaprostanoids and anti-ulcer use thereof|
US4530933A|1982-12-27|1985-07-23|E. I. Du Pont De Nemours And Company|8-Aza-13-thiaprostanoids and a method of use thereof as anti-ulcer agents|
MXPA02006322A|1999-12-22|2002-12-13|Pfizer Prod Inc|Ep4 receptor selective agonists in the treatment of osteoporosis.|
PL362030A1|2000-11-27|2004-10-18|Pfizer Products Inc.|Ep4 receptor selective agonists in the treatment of osteoporosis|
CA2451393C|2001-07-16|2011-01-04|F. Hoffmann-La Roche Ag|2 pyrrolidone derivatives as prostanoid agonists|
JP2004521954A|2001-07-16|2004-07-22|エフ.ホフマン−ラ ロシュ アーゲー|Prostaglandin analogs as EP4 receptor agonists|
DE60239343D1|2001-07-23|2011-04-14|Ono Pharmaceutical Co|MEDICINE FOR THE TREATMENT OF DISEASES COMING WITH BONE SCUM, WITH EP4 AGONIST AS AN ACTIVE AGENT|
CA2477715A1|2002-03-05|2003-09-12|Ono Pharmaceutical Co., Ltd.|8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient|
AU2003209571A1|2002-03-18|2003-09-29|Pfizer Products Inc.|Use of selective ep4 receptor agonists for the treatment of liver failure, loss of patency of the ductus arteriosus, glaucoma or ocular hypertension|
BRPI0406717A|2003-01-10|2005-12-20|Hoffmann La Roche|Compound, pharmaceutical composition comprising the same, method of treating a disease in a mammal, use of the compound and process for its production|
US20080058375A1|2004-01-08|2008-03-06|Elworthy Todd R|2-Piperidone derivatives as prostaglandin antagonists|
US7179820B2|2003-06-06|2007-02-20|Allergan, Inc.|Piperidinyl prostaglandin E analogs|
法律状态:
优先权:
申请号 | 申请日 | 专利标题
IL49325A|IL49325A|1976-03-31|1976-03-31|8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them|
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