• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Hard gelatin capsules are made from gelatin containing up to 10% of a preferably hydrophilic fibrous material. They do not split after storage when filled with hygroscopic or deliquescent materials.
    公开号:SU1743333A3
    申请号:SU884356546
    申请日:1988-09-09
    公开日:1992-06-23
    发明作者:Эллвуд Джоунз Брайан
    申请人:Лилли Индастриз Лимитед (Фирма)；
    IPC主号:
    专利说明:

    This invention relates to the chemical and pharmaceutical industry and relates to hard gelatin capsules.
    The purpose of the invention is to increase the strength of capsules containing hygroscopic or air-sprayed compounds.
    This goal is achieved by introducing into the shell of a hard gelatin capsule a hydrophilic, fibrous compound that swells when water is absorbed — the sodium salt of carboxymethylcellulose. This compound is present in gelatin along with other common ingredients and additives, such as, for example, coloring agents, preservatives, and the like.
    The fibrous compound is present in powder form and the length of the fibers lies in the range of about 50-300 microns.
    An example of such a compound is Croscarmellose / USNF / crosslinked form of sodium carboxymethylcellulose, available from, for example, FMC under the trade name AcD: Sol for use as a disintegrant and dissolving agent. This is a fibrous material consisting of fibers with a length of 50-300 µm and having the following properties: a) it swells upon contact with water and c) holds absorbed water.
    Capsules according to this invention can be prepared by the usual techniques used in the art, a predetermined amount of fibrous compound is added to gelatin before, during and after dissolving the gelatin, for example, in the form of an aqueous suspension, and the molten gelatin bath is stirred until a second is obtained.
    CO CO CO
    with

    with
    A variety of suspension, from which the capsule shells are molded in the usual manner.
    Example. Make a batch number O capsules of gelatin, which introduced 1 and 2% Croscarmellose by adding 1 wt.% Suspension. Each of the many standard capsules and capsules containing fibers is filled with 150 µg of Carnitine, a highly hygroscopic crystalline solid. Samples from each batch of capsules are checked at 5 min intervals by visual detection of broken or cracked capsules.
    Experimental capsules show significantly increased resistance to increased brittleness. Capsules made from gelatin containing 1% Croscarmellose do not crack, and those made from gelatin containing 2% Croscarmellose show only weak
    cracking under these extreme conditions compared to standard capsules, which all become brittle and break down over a time between 10 minutes and 2 hours.
    权利要求:
    Claims (1)
    [1]
    The advantage of the proposed composition of the shell is that protection against cracking of the membranes is provided with smaller amounts of the addition of a hydrophilic compound and no plasticizers are required. Claims A hard capsule shell composition containing gelatin and a hydrophilic compound, characterized in that, in order to increase the strength of the capsule, it contains a cross-linked carboxymethylcellulose sodium salt with a fiber length of 50300 microns in an amount of 1-2%.
    类似技术:
    公开号 | 公开日 | 专利标题
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    同族专利:
    公开号 | 公开日
    AU2198388A|1989-03-16|
    DK500988A|1989-03-12|
    GB8721455D0|1987-10-21|
    PH24232A|1990-05-04|
    JO1548B1|1989-01-25|
    AU606991B2|1991-02-21|
    EP0311255A1|1989-04-12|
    US4892766A|1990-01-09|
    NZ226087A|1990-04-26|
    ZA886686B|1990-05-30|
    DK500988D0|1988-09-09|
    IL87713A|1992-06-21|
    KR890004687A|1989-05-09|
    CN1032106A|1989-04-05|
    JPH01121213A|1989-05-12|
    HU198386B|1989-10-30|
    YU46641B|1994-01-20|
    PT88447B|1992-10-30|
    HUT48457A|1989-06-28|
    PT88447A|1989-07-31|
    EG20414A|1999-02-28|
    IL87713D0|1989-02-28|
    YU169888A|1990-04-30|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US2441927A|1942-10-05|1948-05-18|United States Gypsum Co|Mucilaginous composition|
    US2491475A|1946-03-25|1949-12-20|Parke Davis & Co|Enteric capsule|
    NL63297C|1947-01-11|
    US2575789A|1948-11-15|1951-11-20|Parke Davis & Co|Process and apparatus for manufacturing capsules|
    US2667268A|1951-03-22|1954-01-26|Atlas Powder Co|Aqueous solution inert to gelatin|
    GB752362A|1953-11-09|1956-07-11|Scherer Corp R P|Plasticized gelatin capsules|
    US2990334A|1959-06-29|1961-06-27|Upjohn Co|Gelatin capsules enclosing a watermiscible vehicle|
    GB1093286A|1965-02-15|1967-11-29|Biorex Laboratories Ltd|Improvements in or relating to dosage unit forms for the administration of medicaments and diagnostic agents|
    US3539361A|1968-01-15|1970-11-10|Tee Pak Inc|Method of improving crocking fastness of dyed cellulose sausage casing|
    US3851051A|1970-07-17|1974-11-26|Scherer R Corp|Soft gelatin capsule containing high water content fill|
    US3927195A|1974-01-31|1975-12-16|Lilly Industries Ltd|Production of capsules|
    MX3955E|1975-04-17|1981-10-15|Parke Davis & Co|PROCEDURE FOR PRODUCING A PHARMACEUTICAL CAPSULE THAT HAS ENTERIC PROPERTIES|
    US4428927A|1981-05-11|1984-01-31|R. P. Scherer Corporation|Masticatory soft elastic gelatin capsules and method for the manufacture thereof|
    GR78492B|1982-03-26|1984-09-27|Warner Lambert Co|
    EG16028A|1982-03-26|1986-12-30|Warner Lambert Co|Apparatus and method for molding capsules|
    US4500358A|1982-10-29|1985-02-19|Warner-Lambert Company|Foam capsules|
    DE3307353C2|1983-03-02|1985-01-31|R.P. Scherer GmbH, 6930 Eberbach|Soft gelatin capsule containing polyethylene glycol and process for their production|
    DE3529694C2|1985-08-20|1988-05-11|R. P. Scherer Gmbh, 6930 Eberbach, De|
    GB8522453D0|1985-09-11|1985-10-16|Lilly Industries Ltd|Chewable capsules|GB8701332D0|1987-01-21|1987-02-25|Lilly Industries Ltd|Capsule filling|
    US5071706A|1989-08-31|1991-12-10|Eurand America, Incorporated|Oily, free-flowing, microcapsules|
    FR2666340A1|1990-08-30|1992-03-06|Warner Lambert Co|NOVEL COMPOSITIONS COMPRISING A HYDROPHILIC POLYMER AND A HYDROPHILIC MATERIAL DIFFERENT FROM THE FIRST.|
    EP0525258A1|1991-07-29|1993-02-03|International Business Machines Corporation|Generation of rules-based computer programs|
    US5200191A|1991-09-11|1993-04-06|Banner Gelatin Products Corp.|Softgel manufacturing process|
    SI0649651T1|1993-09-28|2001-02-28|Scherer Gmbh R P|Soft gelatin capsule manufacture|
    ID25786A|1997-12-26|2000-11-02|Warner Lambert Co|GELATIN COMPOSITION|
    DE19835346A1|1998-08-05|2000-02-10|Boehringer Ingelheim Pharma|Two-part capsule for pharmaceutical preparations for powder inhalers|
    US6274162B1|2000-01-14|2001-08-14|Bpsi Holdings, Inc.|Elegant film coating system|
    CN1251670C|2000-08-17|2006-04-19|机械工业公司|Consumable container|
    US20040105883A1|2001-04-17|2004-06-03|Ping Gao|Pharmaceutical dosage form capable of maintaining stable dissolution profile upon storage|
    US20040131670A1|2001-04-17|2004-07-08|Ping Gao|Pellicle-resistant gelatin capsule|
    US20040105885A1|2001-04-17|2004-06-03|Ping Gao|Gelatin capsule exhibiting reduced cross-linking|
    DE102005001332A1|2005-01-11|2006-07-20|Boehringer Ingelheim Pharma Gmbh & Co. Kg|Two-piece capsule with pre-closure for holding pharmaceutical preparations for powder inhalers|
    法律状态:
    2007-12-20| REG| Reference to a code of a succession state|Ref country code: RU Ref legal event code: MM4A Effective date: 20060910 |
    优先权:
    申请号 | 申请日 | 专利标题
    GB8721455A|GB8721455D0|1987-09-11|1987-09-11|Capsules|
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