Method of producing derivatives of delta 4-9-19-norsteroids

专利摘要:
The invention relates to products having the general formula I, wherein R1 is thienyl or phenyl optionally substituted, furyl, cycloalkyl, naphtyl, phenyl-phenyl, alkyl or alkenyl; R2 is methyl or ethyl; R3 is H, OH, alkyl, alkenyl, optionally substituted alkynyl, acetyl, hydroxy acetyl, optionally esterified or salified carboxy alkoxy, optionally esterified hydroxy alkyl; R4 is H, OH, alkyl, alkenyl, alkynyl optionally substituted by amino, alkyl or dialkyl amino, halogen, thioalkyl, alkoxy, trialkylsylyl or cyano; R5 is H or methyl; X is O, hydroxyimino or alkoxyimino; A and B are alpha -epoxy or a second bond; preparation method thereof, application thereof as drugs, compositions containing them and new intermediaries obtained.
公开号:SU1340593A3
申请号:SU833561503
申请日:1983-02-28
公开日:1987-09-23
发明作者:Фильбер Даниель；Жорж Тетш Жан；Костерус Жермен；Дерае Роже
申请人:Руссель Юклаф (Фирма)；
IPC主号:

专利说明:

The invention relates to a process for the preparation of novel steroid derivatives, namely, L-19-nor-steroids derivatives of the general formula
(I)
20
25
de R, - halogen substituted thienyl,
or phenyl substituted by halogen, a lower alkyl group, a lower alkylthiogroup 15, which can be oxidized as a sulfone, a phenyl group, a lower alkoxy or phenoxy group; Rj is a methyl group; RJ is a hydroxyl group; R4 is lower alkynyl; RJ is hydrogen or 0-methyl
group j
X - keto or hydroxyimino, group J
A B is a double bond or epoxy group between carbons 9 and 10,
possessing valuable pharmacological properties.
The purpose of the invention is to obtain new steroid derivatives, which have pharmacological advantages over known steroids with a similar effect.
Example 1. 3,3-Ethylene bis (oxi) 17 (- (prop-1-ynyl) (2-thienyl) estr 9-ene Zo, 17/1-diol.
g
thirty
At -25% Civ, nitrogen atmosphere injected 0.82 g of copper chloride in 162 cm of magnesium thiienyl bromide in tetrahydrofuran (1.05 M / 1), stirred for 15 minutes and added dropwise in a drop so that the temperature did not rise above, a solution of 15 g of 3,3-ethylene bis (oxy) 5o /, 10o-epoxy md- (prop-1-ynyl) estr 9 (11) -en 17/5-ol in 80 cm of tetrahydrofuran. Leave in nitrogen atmosphere, stirring for 1 hour at -25 ° C, and then 2 hours at then poured into ice-cold aqueous ammonium chloride. The mixture is stirred, extracted with ether, the organic layer is washed with water, dried and icocentrated under reduced pressure, 18.8 g of crude product are obtained. Purified by silica chromatography (eluant: chloro
0
five
five
c
forms - acetic acid ethyl ester (9-1), and 9.85 g of product was isolated, m.p. 250 C.
Preparation of the starting product 3,3-ethylene bis (oxy) 3S /, 10 ° (-epoxy-17 ° (- (prop-1-ynyl) estr. 9 (11) -en 17/3-αol, is obtained in the following way.
a) 3,3-bis-methoxy 17 o / - (prop-1-vinyl) estr 5 (10) 9 (11) diene-17 / s-ol. c) Propinemagnesium bromide: In a nitrogen atmosphere, 350 cm of a solution of ethylmagnesium bromide in tetrahydrofuran (1.1 M / 1) is injected. Cool down and let propine pass for 2 hours, maintaining the temperature at 10 ° C in an ice bath. The temperature is allowed to rise to 20 ° C, continuing to pass propyne. A) Condensation:
A solution of 50 g of 3,3-bis-methoxystra 5 (10) 9 (11) - -diene 17-one in 240 cm of tetrahydrofuran and 2 drops of triethylamine is injected into the previous solution at 50 ° C for 50 minutes, and stirred for 75 minutes then poured into ice-cold aqueous ammonium chloride.
The mixture is stirred for 15 minutes and then extracted with ether and washed with 1: 1 solution of sodium hydrogen carbonate in water containing 2 drops of pyridine. Dry, concentrate under reduced pressure and crawl / drink 62.4 g of the crude product, 974 mg of this product are chromatographed on silica eluant: ethyl ether - petroleum ether (bp 60-80 ° C) 3-1 to get 744 mg of the purified product, which is recrystallized, in hot form, in a mixture containing 5.5 cm of isopropyl ether, 0.4 cm of methylene chloride and traces of pyridine. Filtered, concentrated, seeded crystallization, sucked off, washed
isopropyl ether, dried, and obtained: 444 mg of product (pure), so pl. 138 C.
b) 3,3-Ethylene -bis (oxy) 17c5 (- (prop--1-ynyl) estr 5 (10) 9 (11) -diene 17 / j- -ol.
Under a nitrogen atmosphere, 88.5 g of the product obtained are introduced under item a into 442.5 cm glycol. Under stirring and under nitrogen, heated at 60 ° C
0
0
0
iS
and 4.425 g of pyridine hydrochloride is added. Stir for another 15 minutes at, and then cool to 20 ° C, add 17.7 cm while cooling (at 40 ° C)
triethylamine. When the suspension is poured into 3 liters of ice water. Leave for 1 hour at 0 s, and then sucked off, washed with water, dried, and 75.4 g of product are obtained, m.p. ISS-lAO C.
c) 3,3-Ethylene bis (oxy) 5o (, Yus / -epoxy 17o (- (prop-1-ynyl) estr 9 (11) - -en 17e-ol:
30 g of the product obtained in paragraph 6 are cooled to 150 cm of methylene chloride containing 2 drops of pyridine, 1.8 cm 3/3, 3-bis-methoxy 5 sec, 10 ° (epoxy
hexafluoroacetone hydroxide, 4.35 CM of IS17o (- (prop-1-ynyl) estr 9 (11) -en Mjb is added drop by drop
85% hydrogen peroxide, stirred - ol was prepared by the following method, rolled at 0 ° C for 72 hours, then 62.4 g obtained in Example 1
poured into a mixture of 250 g of ice in 500, 3-bis tags and (prop-1-ynil)
0.2 n. sodium thiosulfonate. Move-estr 5 (10) 9 (11) - diene 17 / z-ola-20
Sew and extract with methylene chloride. The organic layer is washed, dried, and concentrated under reduced pressure to obtain 31.6 g of the intended product.
d t under nitrogen atmosphere in 280 cm of methylene chloride. It is cooled to 0 C with stirring and 8.5 cm of a half-hydroxide hexafluoroacetone is added at a time, and then drops
Example 2. 3,3-Ethylene bis (about 25 drop by drop of 10.1 cm 85% peroxide
.si) 1 1 p- (p-fluorophenyl) (prop-1-vinyl) estr 9-ene 5c, 17/3-diol:
3,3-ethylene bis (oxy) 5 °, 10-epoxy Md- (prop-1-ynyl) estr 9 (11) -en 1 7/3-ol in the presence of copper chloride in tetra hydrofuran.
After chromatography, the product is obtained ojjj -57.5 ± 1.5 °
(With 1% CHClg).
Example 3. 3,3-Ethylene bis (ox) 11 /-(p-trifluoromethylphenyl) - (prop-1-ynyl) estr 9-ene 5c /, 17 / h-DIol
Act as in examples 1 and 2, using p-trifluoromethylphenylmagnesium bromide on the same product,
Get the target product a Jp -56t2,5 ° (With 0.4%, CHClj),
Example 4. 3,3-bis-methoxy 11p -methyl 1 (prop-1-ynyl) estr 9-ene 5 o, 17 / b-diol.
Under a nitrogen atmosphere, a mixture of 11.4 g of copper iodide in 120 cm of ether is cooled and 69 cm of methyl lithium of 1.74 M in ether are added over 30 minutes. Stir for another 10 minutes at 0 ° C, and then drop by drop dropwise over 30 minutes, add 5.5 g of 3,3-bis-methyl-hydroxy 5of, 10 ° (epoxy-17 ° (- (prop-1-ynyl estr (11) -en 17 | y-ol in 50 cm of tetra-hydrofuran. Leave for 2 hours with stirring at 0 ° C and then poured into aqueous ice-ammonium solution.

0593
Stir for one hour at room temperature. Extracted with ether, washed, dried, concentrated to dryness under reduced pressure and obtain 5.7 g of crude product.
Chromatograph 6.8 g of the product obtained on silica (eluant: methylene chloride - acetone 9-1 10 at 1% trichloroethylamine). 4.05 g of the expected product are obtained, m.p. I55 c, oi 80 ± 2MS 1%, CHCl j).
Preparation of the original product.
3,3-bis-methoxy 5 s, 10o (-epoxy
d t under nitrogen atmosphere in 280 cm of methylene chloride. It is cooled to 0 C with stirring and 8.5 cm of a half-hydroxide hexafluoroacetone is added at a time, and then drops
hydrogen. Allow 41 hours with and poured with stirring into a mixture of 1.4 cm of a solution of 0.5 M / L sodium bisulfite, 200 g of ice and 5 drops of pyridine. Stir for 15 minutes and then grind methylene chloride containing 2 drops of pyridine. The organic layer is washed with water containing traces of pyridine, dried, concentrated to dryness under reduced pressure, and 63.8 g of the desired prod- uct is obtained.
Example 5. 3,3-bis-methoxy 1 1 / i- (npona-1, 2-dienyl) 17of- (npon-1-0-vinyl) estr 9-ene 5 ° /, 17/5-diol.
c () Allenyl lithium (): Cool to 0 ° C with 300 cm of dry tetrahydrofuran and pass the allen gas to dissolve. about 18-20 g. Then cooled to -70 ° C and a drop of 30 cm of n-butyl lithium in n-hexane of 1.35 is added dropwise in 30 minutes. Stir for 1 hour at -70 ° C.
/ h) Copper lithium dialenlen (CH C CH) j CuLiJ:
To the previous suspension, 24.66 g of the copper dimethylsulfide bromide complex is added in small fractions of about 15 minutes. Stir for another 1 h 30 min at -70 ° C.
s) Condensation on epoxy: At -70 ° C and for 10 minutes a drop of 11 g of 3,3-bis-methoxy 5oi, 10o (epoxy-17o / - (prop5
0
five
513405936
-1-ynyl) estr 9 (11) -en in under reduced pressure. 60 cm of dry tetrahydrofuran are obtained and 5.45 g of crude product are obtained, taken slowly to reach -2G ° C (about t5 C), 370 mg, which are purified by chromatography. Stir at this temperature and on silica (eluant: under nitrogen for 18 hours. Then pour out: benzene – ethyl acetate with acid in ice ice 8-2 with stirring) and separate 450 mg of pure chlorine solution. ammonium. By product, so pl. . after 1 hour of stirring at the computed,%: C 69.38-, H 8.73 j of wadding temperatures® are extracted with ether-ig N 2.89,

Found,%: C 69.4; H 9.0-, N 2.9. Example 29a 3,3-Ethylene bis (oxy) 17o-ethynyl 11 / g-2-methylrom, washed, dried and concentrated to dryness under reduced pressure.
11.2 g of crude desired product are obtained.
Chromatographic on silica-15 - (prop-1-ensh1) estr 9-ene 5o /, 17 / z-diol. nor (eluant: methylene chloride - ace-5.45 g obtained in example 29
tone 9-1 with 1% triethylamine). 6.6 g of the expected product are obtained. “1 -25 + t 1 ° (С 1%, СНС1з).
Example 6. 3,3-bis-methoxy 1 (prop-1-ynil) 11-tert-butyl 9-ene 5, 17/3-diol.
Act as indicated in the impurity product is dissolved in 50 cm of ethylenediamine. The mixture is stirred under nitrogen at 50 ° C and small portions of 6 g of the acetyl-lithium ethylenediamine tilinide complex are added in small fractions. After 3 hours at the same temperature, pour the reaction mixture into a water-ice mixture and
Pe 1, but starting from 13.8 cm, the tert-ise is extracted with ether, and then chlorofortil magnesium chloride in 0.65 M tetrahydro 25. The organic layers are dried, and
thirty
furan and 1.1 g of 3,3-bis-methoxy 5o (, 10o-epoxy (prop-1-ins1) estr 8 (11) -en P / i-ol. After stirring at -20 ° C for 3 h the desired product is obtained, mp 148-150 ° C.
Example 7. 3,3-bis-methoxy 11 / g- (2-furyl) 1 7c / - (prop-1-ynyl) estr 9-ene 5a, 17/9-diol.
Act as in example 5, copper-lithium difuryl is condensed with 3,3-bis-methoxy 5 ° /, 10 (V-epoxy 17 ° (- (prop-1-vinyl) estr 9 (11) -en 17/4-ol .
Get the target product d j -62 t, .5 ° (C 1%, СНС1з).
Examples 8-28. Acting as in example 1, receive products 8-28, which are shown in the table. one. . Example 29. 3,3-Ethylene bis (oxy) 17c / -trimethyl silyloxy 11 / e40
the solvent is then excreted under reduced pressure. Crude product Chromatograph on silica (eluant: benzene - ethyl acetate 7-3 with 0.1% triethylamine) to obtain 2.763 g of the desired product, RP 0.3, which is recrystallized from isopropyl ether, m.p. 208 ° C (0.26 g of product 17-keto is obtained as a by-product) -. Calculated,%: C 75.69; H 8.80;
4 Found: C 75.9, H 8.8.
Example 30. 3,3-Ethylene bis (oxy) 17 ° -prymethylsiloxy 11 / J- (3- methoxyphenyl) 5 3 -hydroxy estr 9-ene 17 -carbonitrile,
The procedure is the same as in Example 1, starting from the product of Example 29, i3-tag- (2-methyl prop-1-yl) 5o-hydroxy 45-ciphenylmagnesium bromide. In this way,
estr 9-ene 17 -carbonitrile. 9.406 g of the expected product are obtained.
A drop is added to the drop at -40 ° C.p. 166 ° C. 32 cm of 0.95 M solution of 2-methyl prop-1-Calculated,%: C 69.23; H 8.06;
-enyl lithium in ether containing 3.1 g of dimethylsulfide bromide and gQd complex in suspension to 30 cm of tetrahydrofuran. 4.16 g of 3- (1,2-ethanedyl) acetal 5 o /, 10 o (-epoxy 17c | (-trimethylsyl hydroxy 17/5 cyanoestr 9 (11) -en 3-one) is added. 55
After 30 minutes, the solution is poured into an ammonium chloride solution and extracted with ether. Dry the organic layer and distill off the solvent.
N 2.60.
C.
Found,%: C 69.4; H 8.1-, N 2.6.
ZoA example. 3,3-Ethylene bis (oxy) 5 °, 17 / -dihydr6xy 11 | b- (3-methoxyphenyl) 19-nor pregn 9-en 20-one.
Concentrate 20 cm of a 1.3 M solution of methylmagnesium bromide in tetrahydrofuran to obtain a solution of 7 cm 2 M of tetrahydrofuran. 2.79 g of the product from example 30 are added and the saturated product is dissolved in 50 cm of ethylenediamine. The mixture is stirred under nitrogen at 50 ° C and 6 g of the acetyl-lithium ethylenediamine complex are added in small fractions. After 3 hours at the same temperature, pour the reaction mixture into a water-ice mixture and
0
0
the solvent is then excreted under reduced pressure. Crude product Chromatograph on silica (eluant: benzene - ethyl acetate 7-3 with 0.1% triethylamine) to obtain 2.763 g of the desired product, RP 0.3, which is recrystallized from isopropyl ether, m.p. 208 ° C (0.26 g of product 17-keto is obtained as a by-product) -. Calculated,%: C 75.69; H 8.80;
4 Found: C 75.9, H 8.8.
Example 30. 3,3-Ethylene bis (oxy) 17 ° -prymethylsiloxy 11 / J- (3- methoxyphenyl) 5 3 -hydroxy estr 9-ene 17 -carbonitrile,
The procedure is the same as in Example 1, starting from the product of Example 29, i3-labels 5phenylmagnesium bromide. In this way,
N 2.60.
C.
Found,%: C 69.4; H 8.1-, N 2.6.
ZoA example. 3,3-Ethylene bis (oxy) 5 °, 17 / -dihydr6xy 11 | b- (3-methoxyphenyl) 19-nor pregn 9-en 20-one.
Concentrate 20 cm of a 1.3 M solution of methylmagnesium bromide in tetrahydrofuran to obtain a solution of 7 cm 2 M of tetrahydrofuran. 2.79 g of the product from example 30 is added and heated with reflux for one night. 10 cm of a 1.3 M solution of an organomagnesium compound are added and 5 cm of tetrahydrofuran are distilled.
100 mg of the product obtained in paragraph a is dissolved in 2 cm of methylene chloride. A50 mg of sodium bicarbonate is added and stirred at. 0.1 cm of chloral is added, and then
and heated at 100 ° C for 7 hours, Hydrolyzed with an ice-cold aqueous solution of ammonium chloride, extracted with ether and dried, and the solvent is distilled off under reduced pressure of 0.1 cm of hydrogen peroxide (110 vol. m). The reaction is terminated by silica chromatography on silica for 4 hours. The reaction mixture is poured (the eluant benzol-ethyl ether is added to a solution of sodium thiosulfate, acetic acid 6-4 with 0.1% triethyl- extracted with methylene chloride and an amine) and obtained 1.722 g of pure cements the solvent is evaporated under a reduced product, which is recrystallized by recrystalline pressure, the mixture is isopropyl
98 mg of the target epoxide is added.
ether - methylene chloride, so pl. 190 ° C. Calculated,%: C, 72.17; H, 7.94;
q, s
, 0.
Found,%: C 72.5, H 8.0.
Example 31. 3,20 bis-ethylene ketal (α-methyl ll / S-propyl 5o {-hydroxy 19-nor pregn 9-ene 3,20-dione. I Starting from 3,20-bis-ethylene ketal. 17c (-methyl) 5O1, 10c / -epoxy-19-nor-preg 9 (11) -ene of 3,20-dione and propylmagnesium bromide, act as in Example 1 (2 hours at -30 ° C).
Preparation of the original product.
3,20-bis-ethylene ketal 17 ° (-methyl 5, 10o-epoxy 19-nor Pregn 9 (11) -ene 3,20-dione is prepared as follows
a) 3,20-bis-ethylene ketal 17c -methyl 19-nor pregn 5 (10) 9 (11)-en 3,20-dione.
1.5 g of p-toluenesulfonic acid monohydrate is added to a solution of 21 g; 17b-meths1 19-norreg 4.9-diene 3.20-dione in a mixture of 200 cm of methylene chloride, 200 cm of ethylene glycol and 100 cm of the ortho-butyl ester. The reaction mixture is heated under reflux for 7 hours and 2 cm of triethylamine are added. Frequently, the solvent is removed by distillation, water is added and the precipitate is collected by filtration, then it is washed with water, dissolved in methylene chloride and dried. After the addition of isopropyl ether and concentration, the target product crystallizes (22.65 g). An analytical sample is obtained by chromatography and then recrystallized in isopropyl ether, etc. 175 C.
Calculated,%: C, 74.96i; H, 9.06.
YAL ".4 Found,%: C75.0; H9; i.
b) 3,20-bis-ethylene ketal 17 "-methyl 5o, 10o (-epoxy 19-norpregn 9 (11) -en en 3,20-dione.
100 mg of the product obtained in paragraph a is dissolved in 2 cm of methylene chloride. A50 mg of sodium bicarbonate is added and stirred at. 0.1 cm of chloral is added, and then
0.1 cm of hydrogen peroxide (110 vol.). The reaction ends after 4 hours. The reaction mixture is poured into sodium thiosulfate solution, extracted with methylene chloride and the solvent is evaporated under reduced pressure.
0
five
0
five
98 mg of the target epoxide is added.
Example 31a 3,20-bis-Etsh1en ketal 17o -methyl 11 9-vinyl 19-nor pregn 9-en 5c; -ola.
Starting from the initial product of example 31 and vinyl magnesium bromide, they act in the same way as in example 1 (2 hours at -30 ° C).
Get the target product, so pl. 192 ° C.
Calculated,%: C, 72.94 H, 9.07.
Found,%: C 72.7, H 9.2. Preparation of the original product.
a) Cool to -50 ° C a mixture of 120 cm of tetrahydrofuran and 6.6 cm of N-cyclohexyl isopr opylamine and add
for 12 min 19.6 cm n-butyl lithium in hexane. 8.9 g of 3,3-ethylene bis (oxy) 17 ° (-methyl 19-norpregn 5 (10) 9 (11) -diene 20-one is added and mixed.
The mixture is stirred at (-35) (-40) C for 1 hour and then 17.4 g of the oxidizing agent (oxodiperpoxyl pyridine hexamethylphosphoramido) molybdenum VI is added and stirred at (-30) - (-35) ° C for 1 hour and 30 minutes. . Then it is poured (- into ice water, extracted with ethyl acetate, washed, then dried and concentrated to dryness.
The residue is chromatographed on silica (eluent: benzene), and 4.03 g of product are obtained, which is taken up in this form in the next step.
b) Cool to (0-5) С a solution of 1,826 g of the obtained 3,3-ethylenedioxy
e 17 -methyl 21-hydroxy 19-norpregn 5 (10) 9 (.11) -Dien 20-it in 18.3 cm of methylene chloride and 7.8 cm of a molar solution of hexafluoroacetone hydroperoxide in chlorofluoride 0
ten
1340593 O
Tilene. 75 minutes are left at (01-5) ° C, syphenyl-magnesium bromide (0.9 M) in tet- and then poured into a 0.5 M solution of Thiohydrolourane and 7.5 g of 20K-acetoxy sodium sulfate. Extracted with chloroform, washed, dried, and obtain 2.02 g of product.
The resulting products: 32-38 are given in Table. one.
Example 39. (3,3-Ethylene bis (oxy) 1 1 / 3- (3- methoxyphenyl) 17 ° - (prop-1-ynyl) 17, i- - estr 9-ene 5c / -hydroxy) tert-butyl ether 17-yl acetic acid.
A solution of 960 mg of 3,3-etipen 6is (ok-xi) 1 (3-methoxyphenyl) 17 (Y- (prop-1-15 lot, and then 40 cm of chloride methyl) estr 9-ene 5o /, 17/3 diol, semi-polyene to a suspension of 45 g of 20K-acetoxy
17o / -metal pregn 4,9-diene 3-one in 180 cm-glycol and 180 cm-ethyl ortoformic acid ester.
Stir for 45 minutes at room temperature under a nitrogen atmosphere, and then add 10 cm of triethylamine.
The solvent is distilled off under reduced pressure. Within 1 hour, one minute 30 minutes is poured into water, 25 cm of 500 cm of ice water is poured, a solution of ammonium chloride is poured, and the mixture is extracted with 2 liters of ice water under stirring. , washed, dried, containing pyridine, evaporated to dryness, and the target is obtained. After stirring at 0 ° C, x5 / 10c / epoxy 3,3-ethylene bis (oxy) 17 / J-methyl 19-nor pregn 9 (11) -ene . After 18 hours, the mixture is stirred at -20 ° C. After chromatography under pressure, 5.4 g of the expected product are obtained, which can be crystallized in ether, m.p. 160 С, о (п +19.5 t 1 (С 1%, CHClj).
Preparation of the original product.
a) With stirring and at 25 ° C, 2.7 g of para-toluenesulfonic acid in Example 13 was added, 30 cm of tetrahydrofuran was cooled to -40 ° C, and 3.2 cm of butyl lithium in n-hexane was added dropwise (1.25 M / l). The temperature is allowed to rise to room temperature, and then a drop of 1.3 cm of t-butyl bromo-acetic acid is added dropwise.
product,
Example 40. 3,3-Ethylene bis (about 50.5 g of product that recrystallized) 11 V-thien-2-yl 17 ° (-methyl 5 °, 21-di-lysis by dissolution with reflux
hydroxy 19-nor pregn 9-ene 20-one. in 10 cm of isopropyl ether, containing 300 mg of copper chloride, added 1% triethylamine and recrystalline 40 cm 0.5 M chienyl magnesium bromide in a cold state. Get
tetrahydrofuran. Cooled to (-20) - 450 mg of the desired product, so pl. 148 ° C.
   +121 t 2.5 ° (С 0.5%, CHCl j).
(-25) C and left in contact for 30 minutes. Then a drop of 2.02 g of 3-ethylene bis (oxy) 17c -methyl 5c, 10o (- -epoxy 21-hydroxy 19-norpregn-9 ( 11) -en 20-it in a solution in 20 cm of dry tetrahydrofuran.
It is left in contact for two hours at (-20) - (-25) C, and then hydrolyzed with an aqueous solution of ammonium chloride.
b) Cool to a mixture of 40 g of the obtained 20K-acetoxy 3,3-ethylene bis (oxy) 17 ° (β-megyl 19-norpregn 40 5,9-diene and 200 cm of methylene chloride containing 0.1 cm of pyridine and add 2.5 cm of a half-hydrated hexafluoroacetone and 1 cm of 85% hydrogen peroxide, and then 0.1 cm
Extracted with ethyl ether and semi-45 pyridine. 2.218 g of resin, which is chromate-7 h at 0 ° C, are stirred for 6 hours, the mixture is poured into 1.5 l.
a solution of 0.2 M sodium thiosulfate, 500 g of ice and 1 cm of pyridine.
Stirred for 10 minutes at room temperature, Rj 0.29, so pl. 240 C. 50 temperature, and then decanted,
extracted with methylene chloride, washed with 0.2 M sodium thiosulfate solution, dried, concentrated to dryness under reduced pressure, and prepared
graphed on silica (eluent: benzene — ethyl acetate 1-1) and 701 mg of the resulting products 41 and 42 are obtained on-. listed in table. one.
Example 43. 20K-Acetoxy 3,3-ethylene bis (oxy) (3-methyloxy-gg 44 g of crude product. Taken at
Nile) 17O1-methyl 19-nor pregn 9-ene 5 o1-ol.
The procedure is as described in Example 40, but starting from 80 cm 3 of methyl 60 C B 40 cm of isopropyl ether containing 1% pyridine, and then allowed to reach room temperature. 27.6 g of the expected product are obtained, mp.
0
syphenyl magnesium bromide (0.9 M) in tetrahydro-Luran and 7.5 g of 20K-acetoxy
15 lots and then 40 cm of methylene chloride to a suspension of 45 g of 20K-acetoxy
5 /, 10c / epoxy 3,3-ethylene bis (oxy) 17 / J-methyl 19-norpregn 9 (11) -ene. After 18 hours, the mixture is stirred at -20 ° C. After chromatography under pressure, 5.4 g of the expected product are obtained, which can be crystallized in ether, m.p. 160 С, о (п +19.5 t 1 (С 1%, CHClj).
Preparation of the original product.
a) With stirring and at 25 ° C, 2.7 g of para-toluenesulfoxane are added, washed, and dried to obtain
 +121 t 2.5 ° (С 0.5%, CHCl j).
b) Cool to a mixture of 40 g of the obtained 20K-acetoxy 3,3-ethylene bis (oxy) 17 ° (β-megyl 19-norpregn 5,9-diene and 200 cm of methylene chloride containing 0.1 cm of pyridine, and add , 5 cm of a half-hydrate of hexafluoroacetone and 1 cm of 85% hydrogen peroxide, and then 0.1 cm
44 g raw product. Taken at
60 C B 40 cm of isopropyl ether containing 1% pyridine, and then allowed to reach room temperature. 27.6 g of the expected product are obtained, mp.
20
25
l60t C, (j, -4,5f 1 (С 1%, СНС1з).
Example 44, Cyclic 1,2-α-ethanediyl acetal 1 (dimethylamino) -prop-1-ynyl 5c /, 1 7 / J-dihydroxy 1 1 1- (3-methoxyphenyl) estr 9-ene 3-one.
a) 3,3-Ethylene bis (oxy) 1 1 /-(3-methoxy) phenyl 5o / hydroxyestr 9-ene
17th
At room temperature, stir to dissolve a mixture of 5 g of 3,3-ethylene bis (oxy) 5 ° /, 10 ° (epoxy estr 9 (11) -en 17-one in 50 cm of tetrahydro-furan, containing 310 mg of copper chloride and 195 mg of lithium chloride. Cooled to -20 ° C and a drop of 31 cm of a 0.75 M solution of 3-methoxyphenylmagnesium bromide in tetrahydrofuran is added dropwise.
It is left at -20 ° C for 1 hour, heated to -15 ° C, and then the same amount of organomagnesium is added.
The mixture is poured into an ice-cold aqueous solution of ammonium chloride, stirred, extracted with ether and then with methylene chloride, the organic layer is washed with a saturated aqueous solution of sodium chloride, dried and the solvent is evaporated.
After chromatography, the desired product is obtained.
b) Cyclic 1,2-ethanedis1 acetal 1 (dimethylamino) -prop-1-vinyl 5o, 17/5-dihydroxy 11 / 3- (3-methoxyphenyl) estr 9-ene 3-one.
Make up to 30 ml of lithium diisopropyl-amide (0.67 M / L) in ether and add 3.9 cm K, M-diethylaminopropine. The temperature is allowed to rise to 0 ° C and then cooled to -40 ° C, and then 4 g of the obtained 3,3-ethylene hydrochloric acid, g si) 11 - (3-methoxy) phenyl 5o (α-hydroxy Pp 9-ene 17-one in a solution of 11 cm of etrahydrofuran.
The temperature is allowed to rise to 0 ° C for 1 hour, poured into 300 cm of a saturated ammonium chloride solution.
g
thirty
35
40
nor, extracted with ethyl acetate, washed with a saturated aqueous solution of sodium chloride, dried, the solvent is evaporated and obtain 4.9 g of the target product. 600 mg of this product is chromatographed on silica (eluant: methylene chloride - methanol, 92-8),
20
25
 .
 g
50
34059312
200 mg of pure product is obtained. Лг -62 t 2,5 (С 0,3 .-, СНС1з). Calculated,%: C 73.6; H 8.3. Found,%: C 73.3, H 8.3. Example 45.HG, 3-Etiley bis
(oxy) 1 1 /} - (4-hydroxyphenyl) 17 ° (- (prop -1 -1 yl) estr 9-ene 5 °, 17 / -diol.
but). Preparation of 4-trimethylsilyl-ig hydroxy phenylmagnesium bromide.
7.8 g of tetrahydrofuran dissolved in 15 cm-, p-bromophenol, and then 5.75 cm of t.rimethylsilyl chloride are added to 50 cm of a 0.9 M solution of isopropylmagnesium chloride in tetrahydrofuran. Pour the solution onto 1.2 g of magnesium shavings. Some 1,2-dibromoethane is added, followed by 2 cm of hexamethylphosphate triamide and then heated for 2 hours and 30 minutes with reflux.
b) 3,3-Ethylene bis (oxy) 1 1 /-(4-hydroxyphenyl) 1 7 ° (- (prop-1-INSh1) extra 9-en 5o, 17/5-diol.
350 mg of copper chloride, and then 1.45 g of 3,3-ethylene bis (oxy) 5U, lOof-epoxy 17 ° (- (prop-1-vinyl) estr 9 (11) -en 17 /} - ol dissolved in 15 cm of tetrahydrofuran, added to 75 cm of the described solution of magnesium-30 organic compound.
Poured into an aqueous solution of ammonium chloride, extracted with ether, washed the organic layer with 1% sodium hydroxide solution. The solvent is dried and then the solvent is distilled off under reduced pressure.
After chromatography on silica (eluant: benzene — ethyl acetate 7-3), 207 mg of the expected product are isolated.
-Calculated,%: C 74.97, H 7.81.
CjgHj Oj
Found,%: C 75.0; H 7.9. i, -58,5 t 2,5 ° (С 0.5%, СНС1з).
35
40
Example 46 17/3 Hydroxy 17o (- (prop-1-ynyl) 11/5- (2-thienyl) estr 4,9-diene 3-one.
9.85 g of the product obtained in Example 1 were introduced into 330 cm of ethanol at 95 ° C. Heated with reflux and 9.85 g of Redex CF resin added at one time. The mixture is left to reflux with stirring and in an atmosphere of nitrogen for 4 hours. It is filtered, rinsed with ethanol and concentrated under reduced pressure. 9 g of crude product are obtained which is chromatographed on silica (eluate: chloroform - ethyl acetate 9-1). 6.5 g of the expected product are isolated, which is recrystallized in isopropyl ether. Sucked off, rinsed with isopropyl ether, dried and get 5,315 g of pure product, so pl. .
Calculated,%: C 76.5j H 7.18; S 8.16.
U A.Oj S
7.5i
GWhv 4 Found,%: C 76.4; H
S 8.0.
Ha (p t83 t 2 ° (1%, CHCIj). The products obtained 47–80 are given in Table 1.
Example 81. tert-Butyl; (3-methoxyphenyl) 3-oxo 17c (- - (prop-1-ynyl) 17/5 estra-4,9-di-17 yl (oxy) acetic acid ester.
Take in 40 cm of methanol and 4 cm 2 N. hydrochloric acid, obtained in the preparation of 36 tert-butyl ester 1 (3-ethylene bis (oxy) 11 / 5- (3-methoxy-phenyl) 17-prop-1-ynyl ) 17 / eEr 9-en 5o-hydroxy 17-yl (hydroxy) acetic acid. After one hour of stirring at room temperature, it is poured into half aqueous bicarbonate solution.
sodium, stirred for 5 minutes, extractor. Dry and then evaporate. Disintegrate the ether and rinse the liquid. The residue is chromatographed on a solution of sodium chloride, dried and on silica (eluant: chlorine-evaporated to dryness under reduced pressure.
methylene chloride (detonation 95-5) and obtain 1.075 g of the expected product, which the residue is chromatographed on dioxid recrystallization in a mixture of methanol, silica siluant: petroleum ether of isopropyl ether, m.p. 185 - (kip. 60-80 ° C) - ethyl acetate acetic acid 7-3. 720 mg of the expected product are obtained.
189 ° C.
Example 92. 9 (h (, 10 ° (—Ephexy 17/5-hydroxy 11 / h- (4-methylsulfonyl)
phenyl 17o - (prop-1-ynil) estr 4-en 3-one.
Within 5 minutes, add 960 mg of 85% methachlorine perbenzoic acid in small portions to the solution.
Example 82 Cd 1; 1- (3-Methoxy-Q phenyl) 3-oxo 17 ° (- (prop-1-ynyl) 17 estr 4,9-diene 17-yl (oxy) acetic acid.
A mixture of 5 g of 570 mg as obtained in Example 36, 500 mg of para-toluene gauge 68, 11 p- (4-methylthio) phenyl sulfonic acid and 100 cm of benzene is heated with reflux for 5 hours. The resulting resin is evaporated to dryness, chromatographed on silica.
50
(eluant: methylene chloride - methanol 92.5-7.5).
Collect 886 mg of the desired product. ir +50, (C 0.3%, in CHCl j).
Example 83. The sodium salt of p-hydroxy 17 "1- (prop-1-ynyl) estr 4,9- -diene 3-one in 13 cm of cooled to methylene chloride.
Stir for 1 h 30 min at 0 ° C and under nitrogen atmosphere, and then with stirring, pour into 100 cm of a 0.5 M aqueous solution of sodium thiosulfate and stir for a while at
- (3-methoxyphenyl) 3-oxo 17 O 1 - (prop-1 - gg room temperature.
- vinyl) estr 4,9-diene 17-yl (ok- Extracted with methylene chloride,
s) acetic acid.
The mixture of 305 mg obtained in Example 82 is stirred to dissolve, washed with an aqueous solution of sodium bicarbonate, dried and concentrated to dryness.
0
g
You and 3 cm ethanol caustic soda (0.2 M / l), filter out a light insoluble substance. It is evaporated to dryness under reduced pressure, the residue is triturated in isopropyl ether until concentrated. Stir, suck and rinse with isopropyl ether. Dry and get 280 mg of the target product, so pl. 270 ° C.
Calculated,%: Na 4,63.
Found,%: Na 4.45.
The resulting products 84-90 are given in table. one.
Example 91.- 9ci, 10s -Epoxy 17 -hydroxy 11 p- (4-methoxyphenyl) 17c / - - (prop-1-ynyl) estr 4-en 3-one.
With stirring, portions of 700 mg of 85% metachlorophenol-Q-doped acid are added to the solution at 1.3 g, prepared as in Example 59, 11; b- (4-labeled C) phenyl. 17 g-hydroxy 17o / - (prop-1-ins1) estr 4,9-diene-3-one in 25 cm of methylene chloride.
After one hour, the temperature is allowed to rise to room temperature, washed with 0.5 N aqueous sodium thiosulfate solution and then with a saturated aqueous solution of sodium bicarbonate.
methylene — and detonation 95–5) and obtain 1.075 g of the expected product, which is recrystallized in a mixture of methanol, isopropyl ether, m.p. 185 -
189 ° C.
Example 92. 9 (h (, 10 ° (—Ephexy 17/5-hydroxy 11 / h- (4-methylsulfonyl)
phenyl 17o - (prop-1-ynil) estr 4-en 3-one.
Within 5 minutes, add 960 mg of 85% methachlorine perbenzoic acid in small portions to the solution.
570 mg as obtained in Example 68, 11 p- (4-methylthio) phenyl
570 mg as obtained in Example 68, 11 p- (4-methylthio) phenyl
-hydroxy 17 "1- (prop-1-ynil) estr 4,9- -diene 3-one in 13 cm cooled to methylene chloride.
Stir for 1 h 30 min at 0 ° C and under nitrogen atmosphere, and then with stirring, pour into 100 cm of a 0.5 M aqueous solution of sodium thiosulfate and stir for a while at
washed with an aqueous solution of sodium bicarbonate, dried and concentrated to dryness.
15
The product obtained is chromatographed on silica (eluant: bezol — ethyl acetate 1-1). 750 mg of the expected product are obtained, which is recrystallized in a mixture of isopropyl ether and methylene chloride.
(, CHCl),
93. 3-Methoxyimino
m.p. 205-208 С. +67,5 t 1,5 °
P RIM e p
- 1 1 / 5- (4-bromophenyl) 17 ° (- (prop-1-ins1) estr 4,9-diene 17l-ol isomers syn (Z) and anti (E);
170 mg of methylhydroxylamine hydrochloride is added to a solution of about 700 mg of the product obtained as in Example 67, 11 / g - (4-bromo) phenyl 1 -hydroxy (prop-1-ynyl) estr 4,9-dien 3- it is 10 cm of ethanol and stirred for 2 hours at room temperature. Poured into water, extracted with ether and then with methylene chloride. The organic layer is dried, the solvent is distilled off and the residue is chromatographed on silica (eluant: benzene — ethyl acetate 9-1)
Thus, 408 mg of an anti-isomer product are obtained (E), mp, 185 C, and then 200 mg of an isomer product syn (Z), t, mp, 217 C,
Anti product analysis:
Calculated,%: C 68.1; H 6.52; 2.83i Br 16.16.
Found,%: C 68.3; H 6.6; 2.9; Br 16.0.
Example 94, 11 / a- (3-Fluorophenyl 3-hydroxyimino (prop-1-ynyl) estr 4,9-diene 17/5-ol isomers syn (Z and anti (E).
At one time 1.27 g of hydroxylamine hydrochloride was added to a solution of 3.7 g such as that obtained in Example 71, 11/5- (3-Fluoro) phenyl-hydroxy 17 ° (- (prop-1-ynyl) estr 4, 9- -diene 3-one, in 44.4 cm of absolute ethanol and 7.6 cm of pyridine.
It is heated for 1 hour with reflux, cooled to 0 ° C, and then poured with stirring into 450 cm of water-ice mixture. Extracted with methylene chloride, the organic layer was washed with water, dried, then concentrated under reduced pressure.
N
N







The crude product is chromatographed under pressure (eluant: cyclohexane-ethyl acetate 7-3). 2.7 g of anti isomer (e) and 857 mg of isomer (Z) are obtained.
0
five
0
five
0
sixteen
The product is anti-recrystallized in a mixture of 20 cm of isopropyl ether and 10 cm of methylene chloride. Obtain 2.145 g of pure product, so pl. . +35 2.5 (, 5%., CHClj).
%: C 77.3, H 7.21;
0
five
Calculated N 3.34.
Found,%: C 77.3; H 7.5, N 3.3. Example 95. 1 1; 5-tert-Butyl 9o /, 10o-epoxy 17p-hydroxy 17c / - (prop-1-ynyl) estr 4-yong 3-one.
I act as in example 91, but proceeding from 2.11 g such as that obtained in example 51, 1 1 9-tert-butsh1 hydroxy 17 (/ - (prop-1-ynil) estr 4,9- -diene 3-one and 2.92 g of metachloroperbenzoic acid, after chromatography, 0.55 g of the expected product is obtained, mp 186-187 C.
Calculated,%: C 78.49; H 8.96, Found,%: C 78.4; H 9.0. d +38 ± 1 (С 1%, СНС1з).
Example 96, 11/3-Piclopentyl 9of, 10o / epoxy 17/5-hydroxy 170 / - - (prop-1-yl) estr 4-en 3-one
Act as in example 91, but starting from 1.5 g such as that obtained in example 48, 11-cyclopentyl 17/5-hydroxy-17 °. - (prop-1-ynyl) estr 4,9- -diene 3-one and 0.8 g of meta-chlorinatedbenzoic acid. After chromatography, 0.7 g of the expected product is obtained, m.p. .
Calculated,%: C 79.15; H 8.68. Found,%: C 79.6; H 8.7. c / Jj +6.5 1 1 ° (, CHClj). Example 97. 1 1 / 3- (3-Metoxyphenyl) 9 (3 /, 10 ° / -epoxy 17; b-hydroxy - (prop-1-ynyl) zstr 4-en 3-one,
Act as in Example 91, but starting from 1.05 g of a product such as in
45 example 58, 11 /} - (3-methoxyphenip) 17 /} - -hydroxy 17o / - (prop-1-ynyl) estr 4,9- -diene 3-one and 0.608 g of metachloroperbenzoic acid. After chromatography, 0.65 g of the expected product is obtained.
50 iZv +43 t 2.5 (, 6%, СНС1з).
Example 98. 11 /} - Phenyl 9 (3 /, 10 |) / - epoxy 17-hydroxy 17 ° (- (prop-1-vinyl) estr 4-en 3-one.
Act as in example 91, but
55 on the basis of 1.15 g of the product obtained in Example 65, 11/3-phenyl 17 -hydroxy-17 ° ;-( prop-1-ynyl) estr 4,9-diene 3-one and 0.608 g of metachloro benzene acid .
17
After chromatography, 85 g of crystals are obtained, mp. ISG-ISy C.
Calculated,%: C 80.56; H 7.51.
Found,%: C80.6; H7.3.
 +47.5 ± 1.5 (, CHClj).
Example 99. 11 / z- 4 (3-Methyl) butyl sulfonyl phenyl 9o1, 10 (/ - epoxy 17/3 -hydroxy 17o / - (prop-1-vinyl) e p 4-en 3-one.o
Act as in Example 92, but starting from 1 1 /) - G4- (3-methyl) butylthio-phenyl 17/3-hydroxy 1 7c / - (prop-1-vinyl) estr 4,9-diene 3-one, such as
thirty
35
OH is obtained in example 92. Get de-g in example 45) 2 cm of methanol and 0.3 cm of the left product, so pl. .
 +62 t 2.5 (, 6%, СНС1з).
Example 100. 23-K, K-Dimethyl-amino 1 7 / e-hydroxy 11p- (3-methoxyphenyl) 19-21,24-trinor Md-shop 4,8-di-2o en-20-in 3 -he,
One hour at room temperature is stirred at 4.3 g of the product, obtained as in Example 100, cyclic ethanediyl acetal (dimethylamino 25
1-PrOPINYL) 5c /, 1 7; 9-DIGIDROXI 1 1; 9 (-Z-methoxyphenyl) estr 9-en 3-one in 100 cm of methanol and 3 cm 2 n. hydrochloric acid.
Poured into a mixture of 300 cm of ethyl acetate and 200 cm of an aqueous solution (0.25 M) of sodium bicarbonate. Decanted, re-extracted with ethyl acetate, the organic layers are combined. It is washed with a saturated aqueous solution of sodium chloride, dried, the solvent is evaporated, and the residue is chromatographed on silica: Gelutant (methylene chloride - methanol 95-5) (acetone - ethyl acetate 3-1) J. 1.7 g of the desired product, taken up in this form in the next stage, is isolated, d +40 i 1 ° (C 1%, CHCl).
Example 101. 23- -N, N-Dimethylamino 17 -hydroxy 11p- (3- -methoxyphenyl) 19,21,24-trinor-1 70 / - -ola-4,9-diene 20-in 3-one hydrochloride.
1.5 g of the product obtained in Example 100 is dissolved in 50 cm of ether, stirred for 10 minutes at room temperature and the light insoluble matter is removed. A drop of 16.5 cm of an ethereal solution of saturated hydrochloric acid is then added dropwise. The suspension is stirred for 10 minutes, then sucked off, rinsed with ether and obtain 1.4 g of the target product.
40
45
50
55
2 n. hydrochloric acid. Poured into ice-cold sodium bicarbonate solution, extracted with ether and then with methylene chloride.
The organic layer is washed with a saturated aqueous solution of sodium chloride, dried, concentrated to dryness under reduced pressure, and the residue is chromatographed on silica (eluant: methylene chloride - acetone 92.5-7.5). 71 mg of the desired product is obtained, o / Jp + 67 ° (C 0.25%, CHCl 3).
Example 103 1 1 / 3- (3-Hydroxyphenyl) 1 7 / L-hydroxy 1 7aif- (prop-1-ynyl) estra 4,8-dienone.
Stage A. 3,3-Ethylene dioxy 1 - 3- (2-tetrahydropyranyloxy) phenyl (prop-1-ynyl) estr 9-ene 5.o /, 17 / 3- -diol.
but). Preparation of organomagnesium compound.
Under nitrogen atmosphere, 20.6 g of methabromophenol tetrahydropyranyl ether and 160 cm of tetrahydrofuran interfere. Pour 10 cm of the solution onto 2.2 g of magnesium chips, and then after starting the reaction, slowly pour the rest of the solution, keeping the temperature at 52 ± 2 ° C. Then heated with reflux for 30 minutes and cooled to 20 ° C.
b). Addition of organomagnesium compound.
In an inert gas, 5.55 g of 3,3-ethylene dioxy 5c /, 10o / epoxy - (prop-1-ynyl) estr 9 (11) -en 17/5-ol in 55 cm of tetrahydrofuran are dissolved and 0 , 36 g anhydrous copper chloride and 0.18 g lithium chloride. Within 30 minutes, 102 cm of the obtained organomagnesium compound solution was added to the solution. They are kept for 1 hour with stirring and at 0 ° C, and then 50 cm of water is added.
18 49 1
2 (, 05%, C 72.63; H 1.12;
ten
m.p. 190 C, water).
 Calculated,%: N 2.82.
Found,%: C 72.5, H 7.7; N 2.7.
Example 102. 1 7 / a-Hydroxy 1 7o (- (prop-1-inip) 11 / h- (4-hydroxyphenyl) estr 4,9-diene 3-one.
At room temperature, a solution of 90 mg of 3,3-ethylene bis (oxy) 11J | - (4-hydroxyphenyl) 17 (prop-1-ynil) pp-9-en 5o / 17/3 is stirred for 2 hours. diol (such as it is obtained
in example 45) in 2 cm of methanol and 0.3 cm
2 n. hydrochloric acid. Poured into ice-cold sodium bicarbonate solution, extracted with ether and then with methylene chloride.
The organic layer is washed with a saturated aqueous solution of sodium chloride, dried, concentrated to dryness under reduced pressure, and the residue is chromatographed on silica (eluant: methylene chloride - acetone 92.5-7.5). 71 mg of the desired product is obtained, o / Jp + 67 ° (C 0.25%, CHCl 3).
Example 103 1 1 / 3- (3-Hydroxyphenyl) 1 7 / L-hydroxy 1 7aif- (prop-1-ynyl) estra 4,8-dienone.
Stage A. 3,3-Ethylene dioxy 1 - 3- (2-tetrahydropyranyloxy) phenyl (prop-1-ynyl) estr 9-ene 5.o /, 17 / 3- -diol.
but). Preparation of organomagnesium compound.
Under nitrogen atmosphere, 20.6 g of methabromophenol tetrahydropyranyl ether and 160 cm of tetrahydrofuran interfere. Pour 10 cm of the solution onto 2.2 g of magnesium chips, and then after starting the reaction, slowly pour the rest of the solution, keeping the temperature at 52 ± 2 ° C. Then heated with reflux for 30 minutes and cooled to 20 ° C.
b). Addition of organomagnesium compound.
In an inert gas, 5.55 g of 3,3-ethylene dioxy 5c /, 10o / epoxy - (prop-1-ynyl) estr 9 (11) -en 17/5-ol in 55 cm of tetrahydrofuran are dissolved and 0 , 36 g anhydrous copper chloride and 0.18 g lithium chloride. Within 30 minutes, 102 cm of the obtained organomagnesium compound solution was added to the solution. The mixture is kept for 1 hour under stirring and at 0 ° C, then 50 cm of an aqueous solution of ammonium chloride and decanter are introduced, extracted with ethyl acetate, the organic layer is washed with water, dried and the solvent is evaporated. The residue is chromatographed on a luvoc silicon oxide, eluted with a mixture of methylene chloride - acetone (95-5) containing 1% triethylamine. 6.3 g of the expected product are obtained, Q qi (T), tritiated product
in ethyl ether - R or 17,2 1-dimethyl-19-nor - - prekotory and crystallize re, so pl. .
Stage B. 1 T / C-C3-Hydroxyphenyl) 1 7/5-hydroxy 1 7 (U (prop-1-ynyl) estr, A, 9-diene 3-one.
When inert gas is introduced into the suspension and under an atmosphere of inert gas, 5.42 g of the product obtained in stage A, 100 cm of ethanol at 95 ° C, 5.5 g of Derek's resin CF are added and then heated with reflux for 1 hour 30 min The mixture is filtered off, the solvent is evaporated and the residue is chromatographed on silica, the eluir is cyclohexane-ethyl acetate (1-1). Obtain 3.8 g of the target product, which is crystallized in ethyl acetate and then in acetone, mp, 215 C.
o (j) +34.5 ± ° (С 1%, CHClj).
Calculated,%: C 80.56-, H 7.51.
 (P2,51)
Found,%: C 80.5; H 7.5.
Tests were performed to compare the activities of the following products:
Product X: 1 1 (9- (p-methoxyphenyl) 17o / -methyl 4 ° estr diene-17/3-ol 3-one (Example 30), product U: (p-fluorophenyl) 17-ethynyl J Estr dien-17o / -ol 3-one (Example 33), and the product Z: .11 / 3- (2-thienyl) 17 ° C-ethynyl estrina diene 17 / C-ol 3-one (Example 15), the activity of the products examples 47, 55-57, 64, 68, 71, 73, 81, 77, 79, 80, 83, 84, 91, 92 and 94.
The tests are carried out to determine the relative affinity of the compounds for the progestogenic and glucocorticoid receptors and the antiglucocorticoid effect of the compounds.
A. Progrestogenyr receptor of the uterus of rabbits.
Immature rabbits weighing about
15
20
25
thirty
35
40
45
50
genadien-3,20-dione in the presence of increasing concentrations of w (0-2500 x 10 m) of cold R, cold progesterone, or cold test compound. The concentration of bound tritium-bound tritium R (B) was then measured for each incubated sample by the adsorption method on carbon-dextran.
B. The glucocorticoid receptor of the rat gland foci.
Male Sprague-Dawley EOPS rats weighing 160-200 g removed the adrenal glands and after 4-8 days the animals were killed. The helical glands were removed and homogenized with a buffer solution containing 10 mM Tris, 0.25 M sucrose, 2 mM dithiotriintol, HC1 for pH 7.4 using a Potter polytetrafluoroethylene glass at a rate of 1 g per 10 ml TC. The homogenate was ultra- centrifuged at 105,000 g for 90 min and aliquots of the obtained supernatant were incubated for a period of time (t) with a constant concentration (T) of tritium-labeled dexamethasone in the presence of an increasing concentration (O -) of either cold dexamethasone, or cold test product. The concentration of bound, tritiated dexamethasone (B) was measured for each incubated sample by the adsorption method on carbon-dextran.
The calculation of relative concentration affinity (ARL) was identical for the two, mentioned receptor tests. One gave the following two curves: the percentage of the tritiated hormone B / T as a function of the logarithm of the concentration of cold hormone and B / T, as a function of the logarithm of the concentration of the cold test product. One determined the equation line.
1 kg, 25 μg of estradiol was injected through the skin, and animals were killed after 5 days. removed, weighed and homogenized at 0 ° C using polytetrafluoroethyl glass P &
containing buffer TC pacTiiopo (Gris 10 mM, 0.25 M sucrose, HCi pll 7.4) with 1 g of tissue per 50 ml of TC. Ultracentrifugal homogenate at 105,000 g for 90 min with and aliquots of the obtained packing liquid were incubated at 0 C for a time (t) with constant concentration 5
0
five
0
five
0
five
0
five
genadien-3,20-dione in the presence of increasing concentrations of w (0-2500 x 10 m) of cold R, cold progesterone, or cold test compound. The concentration of bound tritium-bound tritium R (B) was then measured for each incubated sample by the adsorption method on carbon-dextran.
B. The glucocorticoid receptor of the rat gland foci.
Male Sprague-Dawley EOPS rats weighing 160-200 g removed the adrenal glands and after 4-8 days the animals were killed. The helical glands were removed and homogenized with a buffer solution containing 10 mM Tris, 0.25 M sucrose, 2 mM dithiotriintol, HC1 for pH 7.4 using a Potter polytetrafluoroethylene glass at a rate of 1 g per 10 ml TC. The homogenate was ultra- centrifuged at 105,000 g for 90 min and aliquots of the obtained supernatant were incubated for a period of time (t) with a constant concentration (T) of tritium-labeled dexamethasone in the presence of an increasing concentration (O -) of either cold dexamethasone, or cold test product. The concentration of bound, tritiated dexamethasone (B) was measured for each incubated sample by the adsorption method on carbon-dextran.
The calculation of relative concentration affinity (ARL) was identical for the two, mentioned receptor tests. One gave the following two curves: the percentage of the tritiated hormone B / T as a function of the logarithm of the concentration of cold hormone and B / T, as a function of the logarithm of the concentration of the cold test product. One determined the equation line.
IjQ В / Т (max) + В / т (min :) 2. where V / T, (max) is the percentage of spanno,
21
B / T (min) tritium-labeled hormone for incubating a hormone at a concentration of Ti, the percentage of tritiated hormone labeled for incubation, a labeled tritium hormone at a concentration (T) in the presence of a large excess of cold hormone (2500-10 M) Line 1 intersection point and The curves determine the concentrations of cold reference hormone (CH) and cold test compound (CX), which inhibit 50% of the tritium-labeled hormone-receptor connection. The relative binding affinity (ARL) of the test product was determined by the equation
ARL 100. (CH / CX). . C, Anti-glucocorticoid action.
The test used was a test by Dauss et al. Called the Relationship between the glucocorticoid structure and the effects on the thymocytes for mouse thymocytes. The thymocytes of rats with the adrenal glands removed were incubated at 37 ° C for 3 hours in a nutrient medium containing 5-10 mol of dexamethasone in the presence or absence of the test substance at various concentrations. The tritiated uridine was added and the incubation was continued for 1 hour. The incubated samples were cooled and treated with 5% trifluoroacetic acid solution and the mixture was filtered through Whatman SE / A paper. The filter was washed three times with a 5% solution of trifluoroacetic acid and the residual radioactivity on the filter was determined. Glucocorticoids, and especially dexamethasone, caused a decrease in the use of tritiated uridine and the test compounds of Examples 47, 55, 56, 57, 59, 64, 68, 73, 71 and 84 interfered with this effect. The results are summarized in table. 2
I. Study of the effects of the products of the invention on hormone receptors.
Mineralocorticoid receptor in rat kidney.
Weighing from 140 to 160 g rats male breed Sprague-Dawley EOPS with
59322
4-8 days earlier, the adrenal glands are killed and your kidney is perfused in place with 50 ml of Tris 10 mM buffer solution, 0.25 M sucrose, HC 1 pH 7.4. Then the kidneys will release
0
0
 Potter tefpon glass (1 g of tissue for 3 ml of buffer solution). The homogenization product is centrifuged for 10 min at 0 ° C and in 800 g.
To remove the fixation of tritiated aldosterone on the glucocorticose receptor, 11 / ;, 17-dihydroxy 21-methyl preg 1,4,6-triene 20-in 3-one steroid that is fixed only on the glucocorticoid receptor, is added to the existing on the surface of the product at a final concentration of c. This surface product separates in an ultracentrifuge at 105,000 g for 60 minutes at. Thus, the resulting aliquot portions of the surface product are incubated with a constant concentration (T) of tritiated aldosterone in the presence of an increasing concentration (0-2500), cold aldosterone, or a cold studied product. After the incubation time (T), the concentration of tritiated aldosterone (B) saturated is measured by the absorption of carbon-dextran.
Androgen receptor prostate rat.
Male rats of the Sprague Dawley EOPS breed weighing 160-200 g are neutered. 24 hours after castration, the animals are sacrificed, the prostates are removed, weighed and subjected to homogenization at 0 ° C using Potter Teflon - glass in TS buffer solution (Tris 10 mM, sucrose 0.25 M, HC1 pH 7.4) (1 g of tissue 5 ml TS). The homogenization product is then subjected to ultracentrifugation (105,000 g for 60 minutes) at. The aliquots of the surface product thus obtained are incubated at 0 ° C for the time E of incubation with a constant concentration (T) of tritium testosterone in the presence of a higher concentration (0-1000 M), either cold testosterone, or the product under study. Then the concentration of bound tritiated
five
0
five
0
five
testosterenone (B) is measured in each incubation product by the carbon-dextran absorption technique.
Progestogenic receptor of the female uterus of the rabbit.
Weighing about 1 kg, not reaching puberty, rabbits receive percutaneous administration of 25 μg of estradiol. 5 days after this treatment, the animals are sacrificed, the uterus is removed, weighed and homogenized at 0 ° C, using Potter Teflon glass in a TS buffer solution (Tris.- 10 mM, Sucrose 0.25 M, HC1 pH 7.4) ( 1 g of tissue per 50 ml TS). The homogenization product is then subjected to ultracentrifugation at (105,000 g for 90 minutes). In this way.
25
current concentrations (0–1000–10 M) of either cold estradiol or cold test product. The concentration of bound tritium (b) estradiol bound is then measured in each incubation product by the carbon-dextran absorption technique.
Calculation of relative affinity of communication.
The calculation of the relative affinity of communication (SLA) is the same for all receptors.
Damn two curves: the percentage of tritiated hormone saturated
AT
35 ;;; depending on the logarithm of the concentration of the cold control hormone B
thirty
the aliquots obtained are surface-on-estradiol, in the presence of magnification. .-. / -t tpg, .1 f
This product is incubated at (f C for a time (t) with a constant concentration (T) of tritiated product. R (17,21-dimethyl 19-nor-4,9-pregnadien 3,20 1-dione) in the presence of increasing concentrations (0-2500 x 10 M) of either R cold or cold progesterone or the cold product studied.The concentration of bound tritiated R (c) is then measured in each incubation product by the absorption technique on carbon-dextran.
The glucocorticoid receptor of the rat goiter.
Weighing 160-200 g male Sprague Dawley EOPS rats of the breed are removed adrenal glands. 4-8 days after this removal, the animals are sacrificed and the goitre glands are removed and homogenized at 0 ° C in Tris 10 mM buffer solution, 0.25 M sucrose, 2 mM dithiotrautol, HC1 pH 7.4, using Potter polytetrafluoroethylene glass (1 g of tissue per 10 ml of TS). The homogenization product is then subjected to ultracentrifugation (105,000 g for 90 minutes) at 0 ° C. Thus, the resulting aliquots of the surface product are incubated for a time (t) with a constant concentration (T) of tritiated dexamethasone in the presence of an increasing concentration (0-2500-10 M) of either cold dexamethasone or the cold product under study. Then the concentration of bound tritiated dexamethasone (c) is measured in each of the products.
And Depending on the logarithm of the concentration of the studied cold product.
45
50
55
The direct equations T – C are determined (,
g B B -, / „B L; j max. + - where max. The percentage of tritiated hormone bound to the incubator for the incubation of this tritiated hormone at concentration (T), min, is the percentage of bound
tritiated hormone to incubate this tritiated hormone at a concentration (T) in the presence of a large excess of cold hormone (2500-10-9 M).
The intersections of direct I with the curves make it possible to determine the concentrations of cold, control hormone (CH) and the studied cold product (CX),
Those incubation techniques are coal-dextran ingestion.
Zgrogenic receptor of the uterus mypii.
Those who are not reaching sexual age at the age of 18–21 days are killed by the female, the uterus is collected, and then homogenized by RT. using Potter Teflon glass in TS buffer solution (Tris 10 mM, sucrose 0.25 M, HC1 pH 7.4) 1 g of tissue per 25 ml TS). The homogenization product is then subjected to ultracentrifugation. (105,000 g for 90 min) at. In this manner, the resulting aliquots of the surface product are incubated at or for a time (t) with a constant concentration (T) of the estimated tritium.
current concentrations (0–1000–10 M) of either cold estradiol or cold test product. The concentration of bound tritium (b) estradiol bound is then measured in each incubation product by the carbon-dextran absorption technique.
Calculation of relative affinity of communication.
The calculation of the relative affinity of communication (SLA) is the same for all receptors.
Damn two curves: the percentage of tritiated hormone saturated
AT
;;; depending on the logarithm of the concentration of the cold control hormone B
 estradiol, in the presence of increase .-. / -t tpg, .1 f
And Depending on the logarithm of the concentration of the studied cold product.
five
0
five
The direct equations T – C are determined (,
g B B -, / „B L; j max. + - where max. The percentage of tritiated hormone bound to the incubator for the incubation of this tritiated hormone at concentration (T), min, is the percentage of bound
tritiated hormone to incubate this tritiated hormone at a concentration (T) in the presence of a large excess of cold hormone (2500-10-9 M).
The intersections of direct I with the curves make it possible to determine the concentrations of cold, control hormone (CH) and the studied cold product (CX),
The compounds tested, especially the product of Example 84, have a greater anti-glucocorticoid effect than the known compounds X, Y and Z.
25134059326
which inhibit by 50% the bond of tritiated hormone on the receptor.
Relative affinity of communication (SLA). The product being studied is determined by the equation:
(with and 1

权利要求:
Claims (1)
[1]
The invention The method of obtaining derivatives of s-19-norsteroidov General formula
10 „R g
-R
SLA 100 {U
The results are shown in Table. 3
The products studied, in particular the product of example 68, show a pronounced affinity for the glucocorticoid and progestogenic receptors, as well as moderate affinity for the androgen receptor.
From the results obtained, it can be concluded that the products can exhibit agonism or antagonism of glucocorticoids, progestogens and androgens.
Ii. Anti-glucocorticoid activity.
The technique used is derived from the Dauss method for the goiter glands.
The goiter glands of rats with adrenal glands removed are incubated at 37 ° C for 3 hours in a nutrient medium containing M dexamethasone in the presence or absence of the test product at various concentrations. Add tritiated uridine, and continue incubation for 1 hour. Cool the incubation product, treat it with 5% trichloroacetic acid solution, filter on Whatman paper gF / A, wash three times with 5% trichloroacetic acid solution . The radioactivity retained by the filter is determined.
Glucocorticoids and in particular dexamethasone cause a decrease in the addition of tritiated uridine-HEO. Examples 55-57, 58, 68, 71, 77, 79, 80, 86, 91, 92 and 94 resist this effect. The results are shown in Table. four.
Regarding the toxicity of the target products, it should be noted that there is no toxicity when using the compounds in usual doses.
The results showed that the studied compounds, especially the products of examples 11 and 14, showed a greater affinity for the glucocorticoid and progestogenic receptors than the known compounds X, Y and Z ..
Rt
(one)
15
where R is halogen-substituted thienyl,
or phenyl, substituted halo gene, lower alkyl group
sing, a lower alkylthio group which may be oxidized 20 as a sulfone, by a phenyl group, a lower alkoxy or phenoxy group; Rj is a methyl group; Rj is a hydroxyl group; R4 is lower alkynyl;
RJ, - hydrogen or fl / -methyl
Group;
X is keto or hydroxyiminochus, a group;
30 A and B are a double bond or an epoxy group between carbons 9 and 10,
the fact that the compound of the general formula
35
40
n 1 g "1uN - 4-R.
HE
R.
(Ii)
where RR, and
2 5 Rr
X
45
50
have the indicated meanings;
a hetero group protected as a 3,3-ethylene bi (oxy) group or in a dimethyl ketal,
dehydrated using an acid form of sulfone resin as a dehydrating agent to form a compound of formula
55
where is r,
.-, To K s
 Tr-f--
 R5
(la)
R, and
Rj
RS
have the indicated values.
The compounds tested, especially the product of Example 84, have a greater anti-glucocorticoid effect than the known compounds X, Y and Z.
Rt
(one)
15
where R is halogen-substituted thienyl,
or phenyl substituted by halogen, a lower alkyl group.
Singa, a lower alkylthio group which may be oxidized as a sulfone, by a phenyl group, a lower alkoxy or phenoxy group; Rj is a methyl group; Rj is a hydroxyl group; R4 is lower alkynyl;
RJ, - hydrogen or fl / -methyl
Group;
X is a keto or hydroxyimino group;
A and B are a double bond or epoxy group between carbons 9 and 10,
the fact that the compound of the general formula
n 1 g "1uN - 4-R.
HE
R.
(Ii)
where RR, and
2 5 Rr
X
five
0
have the indicated meanings;
a hetero group protected as 3,3-ethylene bis (oxy) group or as dimethyl ketal,
dehydrated using acidic sulfone resin as a dehydrating agent to form a compound of formula
five
where is r,
.-, To K s
 Tr-f--
 R5
(la)
R, and
Rj
RS
have the indicated meanings.
followed, if necessary, by oxidation with an organic peroxide to give the corresponding 9,10-epoxy derivatives, and in the case when R is phenyl, substituted by lower
3-Methylphenyl- Same magnesium bromide
ten
4-Chlorophenyl magnesium bromide
eleven
2-Chlorothien-5-yl-magnesium bromide
12
3-Chlorophenyl magnesium bromide
3-Methoxyphenylmagnesium bromide
3,3-ethylene bis (oxy) 5o (, 10o / epoxy 7o1- (prop--1-ynyl) estr 9 (11) -en
.14
4-Methoxyfe- Same
nilmagnesium bromide
alkyl thio group, and the corresponding p-phenyl-substituted lower alkylsulfonyl group is obtained, or the resulting compound of formula (la) is reacted with hydroxylamine. IT a b l and c a 1
(C 0.9%, СНС1з)
3,3-Ethylene bis (oxy) 11 / 5- (3-methyl) fen yl (propinyl) estr-95o (, 17 -diol, mp 206 ° C, c -72.5
± 1.5 ° (, СНС1) 3,3-Ethylene bis (oxy) (4-chloro) phenyl 17 ° / - (prop-1-ynyl) zstra 9-en 5 °, 17 | & diol, mp . 180 С, Мр -62t 2 (, СНС1
3.3-ethnlen bis (oxy)
(5-chlorti nile)
17o (- (prop-1 -inil) e p
9-en 5c /, 17 5-diol,
m.p. 204 ° CWi5
-23 ± 1 (, CHCIj
3,3-Ethylene bis (oxy) (3-chlorofensh1) 17 (/ - (prop-1-insh1) zstr 9-ene 5s1, so the melting point. 191 ° C, MD -67,7t 2 ° (, CHClj )
3,3-Etsh1en bis (oxy) 11 /} - (3-methoxyphenyl) 17 ° (- (prop-1 -inyl) estr-9-en 50, ol, - mp. (JfJi, -74 ± 2 ° (, 5%, CHCl,)
3,3-Ethylene bis (oxy) 11e- (4-methoxyphenyl) 17o (- (prop-1-ynyl) estr 9-ene 5o (, 17/1-diol,


15
sixteen
3,4-bis-Methoxyphenyl. Magnesium bromide
3-Trifluoromethylphenylmagnesium bromide
m.p. 226 C, o / JD -68 t 2.5 (, CHClj)
3,3-ethylene bis (oxy) 2 h at
11 | a- (3,4-bis-methoxy) -15 ° C phenyl J 17o / - (prop-1-vinyl) estr 9-ene 5c1, 17 / -diol, mp. 230 ° C, S, 671 12 ° (, 85%, CHClp 1
3,3-Ethylene bis (oxy) 3,3-Ztilen bis (oxy) 30 min
5a (, 10o (epoxy 11 / 5- (3-trifluoromethyl) with
- (prop-1-inil) e page 9 (11) -en 17 / a-ol
phenyl (prop-1- -20 ° C
- vinyl) estr 9-en 5o /,
3-Trifluoromethyl4-chlorophenylmagnesium bromide
Also
18
2-Naphthylmagnesium bromide
nineteen
4-phenoxyphenyl magnesium bromide
3,3-ethylene bis (oxy) 3,3-ethylene bis (oxy) 45 min 5d, yuo-epoxy 11/1- (4-phenoxyphenyl) with
17 ° (- (prop-1-ynil) 17 ° (- (prop-1-ynil) estr -10 ° C
estr 9 (11) -en 9-en 5ei, 17,6-diol,
m.p. , Mr -681 1, (.%,
20
Phenylmagnesium bromide
Also
21
(3-Bromo) phenylmagnesium bromide
11 / 5- (3-trifluoromethyl) with
phenyl (prop-1- -20 ° C
- vinyl) estr 9-en 5o /,
17/3-diol, m.p.
179 ° С, с1 58 t 2
(, 8%, CHClj)
3,3-Ethylene bis (oxy) 30 min
11 /} - (3-trifluoromethyl, with
4-chloro) phenyl 17 ° / - -10 ° C
- (prop-1-inil) e p
9-en 5c, 17 / z-diol,
MD -47.5 t 1.5 °
(, 9%, CHClj)
3,3-Ethylene bis (hydroxy (2-naphthyl) 17o / - (prop-1-ynyl) estr. 9-ene 50 /, 17/3-diol, mp. 276.5 C, -14 ± 2 ° (, 5%, CHClj)
СНС1з)
3,3-ethylene bis (oxy)
11 /} - phenyl 17c / - (prop-
-1-ynil) estr 9-yen
5c /, 17 -diol, t. Pl
234 ° C, MI, -74.5 12.5 (, 5%, СНС1з)
3,3-ethylene bis (oxy)
11/5 - G (3-bromo) phenyl
17th / - (prop-1- ™ yl) estr 9-en 5c /, 17 | i-diol; ) -61
t1,5 ° (, CHClj)
22G (4-Bromo) fe-3,3-Ethylene bis (oxy) 3,3-Ethylene bis (oxy) 30 min
nilmagnesium-5 o /, 10-epoxy 11 - (4-bromo) phenyl at
bromidTuo-Disp-T-ynil) (prop-1-ynil) estr -15 C
estr 9 (11) -en 9-en 5o /, 1 7/9-diol,
 -55 t, 8%, CHClj)
4-Methylthiophenylmagnesium bromide
Also
24
3-thienylmagnesium bromide
Propyl Magnesium Bromide
3,3-Etipene bis (oxy) 5, Yoo-epoxy - (prop-1-ynil) e st 9 (11) -en 17 / z-ol
26
3-Fluorophenyl Magnic Bromide
Also
27
3-Phenylx-phenylmagnesium bromide
28
4pPhenylphenyl magnesium bromide
3,3-Ethylene Bis (hydroxy) 11 / 5- (4-metshtio) fe-D1yl (prop-1-ynil) estr 9-en 5df, 17 / j-diol, 90 ° С, then, MB -5 t1,5 ° (, CHClj)
3,3-ethylene bis (oxy)
11p- (3 thienst)
- (prop-1 inil) estr
9-gene 5S1, 17.4 -diol,
m.p. 240 C, TafJi)
 -38 t2,5 ° (,
CHClj)
3,3-Ethylene bis (oxy) 11 -propyl 17a - (prop--1-ynyl) estr 9-ene 5, 17/3-diol, m.p. ) -108.5 t 3 (C 1%, CHClj)
3,3-ethylene bis (oxy)
(Z-fluoro) phenyl
17c - {prop-1-inil)
estr 9-en 5o, 17 | J-diol, mp 228 ° C,
Md -58,5 t2,5
(C 1Z, CHClj)
3,3-Ethylene bis (oxy) 11j5 - (3-phenyloxy) phenyl 17 ° / - (prop-1-
-inil) estr 9-en 5c (, 17L-DIOL, mp. 190 ° C -59.5 t 1.50 (C 1%, СНС1з)
3,3-Ethylene bis (oxy) (4-phenyl) phenyl (prop-1-vinyl) estr 9-en 5o, 17p-diol, m.p. 165 ° С, -52 t 2 °. (, CHClj)
2
3
four
4-methylthiophenyl magnesium bromide
Dimethyl copper-lithium organic compound
4-methylthiophenyl magnesium bromide
3,20-6is-Ethylene ketal I7oif-methyl 50 /, 10o / -epoxy 19-nor pregna 9 (11) -ene 3,20-dione (obtained according to the example of RU 31)
3,20-bis-ethylene ketal 1bo / -methyl 5c /, 10o (-epoxy 19-nor pregna- -9 (11) -ene 3,20-dione
Also
Cyclopropyl-organic olithium copper
compound
3,3-Ethylene bis (window) 5c /, YusU-epoxy 17o / - (prop-1-ynil) estr 9 (11) -en
4-Isopropylphenylmagnesium bromide,.
Also
37
3-Methylthiophenylmagnesium bromide
3- (2-Propenyloxy) phenylmagnesium bromide
Cyclopentyl magnesium bromide
3.3-3T11len bisSoxy) 3, IOof-epoxy 17t5f- (npon-1 -nyl) estr 9 (P) -en 17 / g-ol
3,3,20,20 bis-ethylene bis (oxy) 17rt -methyl (4-methylthiophenyl) 19-nor pregna-9-en 5o (-ol
3,3,20,20 bis-ethylene bis (oxy) 11, -methyl 19-nor preg on-9-en 50 / -ol, mp, 140 ° C
3,3,20,20 bis-ethylene bis (oxy) 1 6c / -methyl 11p- (4-methylthiophenyl 19-nor pregna-9-en 5o; -ol, mp 189 C
11) 5-Cyclopropyl 3., 3-ethylene bis (oxy) 1 7 (Y (prop-1-ynyl) estr 9-ene 5c, 17/3-diol

3,3-ethylene bis (oxy)
11 / 5- (4-eopropyl-
nid) 1 (prop-1-inil
estr 9-en 50, 17 / a-di
ol, so pl. 194 C,
d (jj, -66,5t 2.5 °
(C 0.5%, CHClj)
3,3-ethylene bis (oxy)
11 / b (3-methylthiophenyl)
17o (- (prop-1-inil) estr
9-en 5c /, 17p-diol,
m.p. ,
 -65.61 2, 7%, СНС1з)
3,3-ethylene bis (oxy)
11 f C3 (2-propenyl
-oxy) phenyl 17 o (- (prop-1-ynyl) estr
9-en 5d, 17/5-diol,
m.p. 165 ° C
 -71 t 2.5 ° (, 8%,
СНС1з)
3,3-Ztilen bis (oxy)
11p-cyclopentyl17o (- (prop-1-ynil)
Estr 9-en ZS,
42
4 (3-Methylbutyl thio) phenylmagnesium bromide
7
eight
9
0
one
52
3,3-Ethylene bis (oxy) - (4-fluorophenyl) (prop-1-vinyl) estr 9-ene 5 ° /, 17/9-diol (Example 2)
3,3-Ethylene bis (oxy) 11D- (4--trifluoromethyl-phenyl) 17 (/ - (prop--1-ynyl) estr 9-ene 5 a /, 17 -diol (Example 3)
3,3-bis-methoxy 11 -methyl 17 (1 / - (prop-1-vinyl) estr 9-en 5o, 17/1-diol (example 4)
3,3-bis-MeTOK-SI (propa--1,2-diensch1) 1 7a - (prop-1-vinyl) ester 9th 5o1, 17 -diol: (example 5)
3,3-bis-methoxy 11 -t-butyl 17 ai- - (prop-1-innl) estr 9-ene 5 s /, 17/1-diol (Example 6)
3,3-Methoxy 11 /} - (2-furyl) 1 7o (- (prop-1 ti
about the same
17L-DIOL, tcl -98 t (, CHCl,)
3,3-Ethylene bis (oxy) 1 h at 11 | b- (3-methyl) butyl-20 C thiophenyl (prop-1-ynyl) estr 9-ene 5a /, 17 -diol,) -52 + 1 , 5 ° (С 0.5%, CHClj)
(4-Fluorophenp) 17 / 3-2h-hydroxy 17 (/ - (prop-1- -insh1) estr 4,9-diene 3-one, mp. 135-140 C, then 162/164 C, Jj , 19 t 1.5 (, 8%, CHCl)
11 /% G (-Trifluormetip) phenyl 17 / -hydroxy - (prop-1-ynyl) estr 4,9-dien 3-one, m.p. 180 С, then 218 С, + 29t Л (, CHClj)
1-Methyl 17; 5-hydroxy 17a (- (prop-1-ynyl) estr 4,9-diene 3-01C, mp. 213 ° C, -153 ± 2.5 C, 1.5%, CHCl)
11 / 5- (Prop-1,2-dienyl) 17 -hydroxy 17o / - (prop--1-ynyl) estr 4,9-diene 3-one, m.p. 133 C, (j, +122 t 2 ° (, 9%, CHClj)
11 / b-tert-butip 17 -cnc
sy 17b (- (prop-1-inil)
estr 4.9-diene 3-one
m.p. 168 C, r.yjjj
- 152t 2.5 (,
CHClj)
(2-Fourche1) 17/5-gnezrok-1 h si 17o (- (prop-1 ynyl) estr 4,9-diene 3-one, so pl.
- vinyl) estr 9-en 5o /, -diol (example 7)
3 3,3-Ethylene bis (oxy) (4-methyl) phenyl j17o / - (prop--1-ynyl) ester 9-ene 5di, -diol (Example 8)
A3,3-Ethylene 6jjc
(oxy) 11/4- (3-methyl) phenyl 17o (- ((prop--1-ynyl) estr. 9-ene 50), -diol (Example 9)
53,3-ethylene bis
(oxy) (4-chloro) phenyl 17o / - (prop--1-ynyl) estr 9-ene 5o (, -diol (Example 10)
563,3-ethylene bis
(oxy) (5- - chlorothyl) 1 7o / - (prop-1-vinyl) ester 9-ene 5 ° /, 1-7 / 1-. -diol (example 11)
573,3-Ethylene bis (oxy) 11 / J- - (3-chlorophenyl) 17o / - (prop-1-vinyl) estr 9-ene 5o /, 17/1-diol (Example 12)
583,3-Ethylene bis (oxy) 11p- - (3-methoxyphenyl) 17o- (npon--1-ynyl) estr
208 ° C, To Ji, + 2,, 5 (,
CHClj)
11p- (4-Methyl) phenyl 17 - -hydroxy 17c / - (psp-1-vinyl) estr 4,9-diene 3-one, m.p. , Yves +70 f 1.5 (С 1%, СНС1з)
1 1/3 (3-Methyl) phenyl 17/1-hydroxy 17 "/ - (prop -1 -1 yl) estr 4,9-diene 3-one, m.p. 182 ° C
 35 ± 1 (1%, СНС1,)
 (4-Chlorine) phenyl
17/3-hydroxy 17o / - (prop--1-ynyl) estr 4,9-diene 3-one, m.p. , 87.12.5 (С 0.5%, CHClj)
11 | 3- (5-chlorothienyl)
17/3-hydroxy 17 ° (- (prop--1-ins1) estr 4,9-diene 3-one, with 115.5 t 2 "(C 1%, СНС1 ,,)
(3-Chlorophenyl) 17/4-β-hydroxy (prop--1-ynyl) estr 4.9-β-diene 3-one, Calculated, C 77.03i H 6.94 Ci 8.42. Found,%: С 76.8j Н 7.0; C1 8.4
11 / 1- (3-Methoxyphenyl) 17/5-hydroxy 17c (- (prop -1-ynyl) estr 4,9-diene 3-one, mp 120 C, Mg, +451 1
9-ene, 17,9- -diol (example 13)
59З 3-Ethylene bis (oxy) 11 /} - (4- -ethoxyphenyl) 17c (- (prop-1-vinyl) estr 9-ene 5 of, 17p-diol (Example 14)
603,3-Etsh1en bis (oxy) 11 - (3, 4-bis methoxy) phenyl J 17.cf- (npon-1-vinyl) estr 9-en 5o (, 1 -diol (example 15)
61 3,3-Etnlen bis (oxy) (3-β-trifluoromethyl) phenyl 17 ° / - (prop--1-ynyl) estr 9-ene 5 (/, 17 -diol (Example 16)
623,3-ethylene bis
(oxy) 11 / J- (3- -trifluoromethyl, 4- -chloro) phenyl - (prop-1-ins1) estr 9-ene 5 (3 /, 17 -diol (example 17)
63 3,3-Ethylene bis (oxy) 11d- (2- -naphthyl) Md- - (prop-1-ynyl) estr 9-en 5of, 1 7 -diol (Example 18)
64 3,3-Ethylene bis (hydroxy) 11 / j- (4-phenoxy phenyl) 1 70 / - (prop-1-ynil) estr 9-en 5o, 17/5-diol (Example 19)
53,3-ethylene bis
(oxy) nyl 17o (- (prop-1-vinyl) estr
(, CHCIj)
11-9- (4-Methoxyphenyl), 17/3-hydroxy (prop-1-ynyl) estr 4,9-diene. 3-he, so pl. 120 С, +73 ± 2 ° (, CHClj)
11 / 5- (3, 4-bis-methoxy) phenyl 1 7у9-hydroxy (prop-1-ynyl) estr 4,9-diene 3-one, m.p. 2094, Wj, + 53.5t1.5 (, 2%, СНС1,)
11 (3-Trifluoromethyl) phenyl 17/3-hydroxy - (prop-1-ynyl) estr 4,9-dien 3-one, m.p. 202 ° С, Wj + 21,5t 1 (, 9%, СНС1з)
11 / J-G (3-Trifluormetsh-1-4-chloro) phenyl 17D-HYDROX-17o (- (pr-1-ynyl) estr 4,9-diene 3-one, mp 188 ° C, cijjf +69 1 2.5 (C 0.7%, SNS)
(2-Naphthyl)
- Hzroksi 17ef- (npdn-1- -insh1) estr 4,9-diene 3-one, so pl. 170 ° С, tci + 252 ± 4 (, CHClj)
(4-phenoxy) phenyl
17 / l-hydroxy 17o / - (prop-1-inl) estr 4,9-diene 3-one, +73.5 i 1.5 (, 8%, CHClj)
11 / -Phenyl 17/5-hydroxy 17 o / - 1 h - (prop-1-ynyl) estr 4,9-diene 3-one, mp, 190 ° С +35.5 ± 2 ° (, 5% ,
9-ene 5o /, 17 / z-diol (Example 20)
3,3-Ethylene bis (oxy) 11, g- (3- -bromo) phenyl 17o (- - (prop-1-ynyl) estr 19-ene 5o (, 17 / s-diol) (Example 2T)
7
eight
9
0
71
72
3,3-Etipene bis (oxy) 11 / s-C (4-bromo) phenyl 17 ° (- (prop-1-ynyl) estr 9-en 5of, 17 /) - diol (Example 22)
3,3-Ethylene bis (oxy) 11 / 3- (4- -methylthio) phenyl 17c / - (prop-1-vinyl) estr 9-ene So /, 17 -diol (Example 23)
3,3-Ethylene bis (oxy) 11 / i- (3- -thienyl) 17 o / - - (prop-1-ynyl) estr 9-ene 5o /, 17/5-diol (Example 24)
3,3-Ethylene bis (oxy) H / j- -propyl 17O1- - (prop-1-ynyl) estr 9-ene 5o (, 17 -diol
3,3-Ethylene bis (oxy) 11/5-t (3-fluoro) fensch1 17o (- - (prop-1-ynil) estr 9-en Zo /, 17 1-diol
3,3-Etipene bis (oxy) 11 / i- (3-fentoksi) phenyl 17 ° (- (prop-1-ynyl)
eleven
CHClj)
11 / 1- (3-Bromo) phenyl 17 / | -hydroxy 17af- (prop-1-ynyl) estr 4,9-diene 3-one, Wn +45.54 1.5 (, CKClj)
Calculated,%: C 69.67; H 6.28; Br 17.17. Found,%: C 69.7, H 6.3; Vg 17.2
1 (4-Bromo) phenyl 17 / l-hydroxy 17o / - (prop-1-vinyl) estr A, 9-diene 3-one, m.p. 214 ° С, +88,5 t 2 ° (,
CHClj)
lip- (4-methylthio) phenyl 17 -hydroxy (prop--1-ynyl) estr 4,9-diene 3-one, m.p. 148-150 ° C, +1351 2.5 ° (, CHCl,)
11 / 5- (3-Thienyl) 17/5-hydroxy 17 ° (- (prop-1-ynyl) estr 4,9-diene 3-one, t.- pl. 202 ° C, Go (in +91 , 51 + 2 ° (, СНС1з)
11/5-Propyl 17/5-hydroxy 17 ° (- (prop-1-ynyl) estr 4,9-diene 3-one, mp. 141 ° C, o (3p -146.5 1 2, 5 (С 0.75%, СНС1з)
(3-Fluoro) phenyl 17 -
hydroxy 17d (- (npon-1-
- vinyl) estr 4,9-diene
3-he, so pl. 172 C,
 +251 2 ° (0.5%,
CHClj)
11p- (3-Phenyloxy) phenyl 17p-hydroxy 17a (- (prop--1-ynyl) estr 4,9-diene, 3-one
estr 9-en 5 (/, diol (example 27)
3
four
3,3-Etipene bis (oxy) (4-phenyl) phenyl 3 17 ° / - - (prop-1-ynyl) estr 9-ene 5o /, 17 -diol (Example 28)
3,3-Ethylene bis (oxy) (2- -methyl prop-1- -lenyl) 17 (/ - ethynyl estr 9-ene 5c /, 17 / ′-diol (Example 29A)
five
6
3,3-ethylene bis (oxy) 5of, 17o / - - dihydroxy 11 /) - -3 (methoxyphenyl) 19-nor pregn 9-ene 20-one (example ZOA)
3,20-bis-ethylene ketal 17o / -methyl 5 -hydroxy-propyl 19-nor pregn 9-ene 3,20-dione (Example 31)
3.3-20.20 bis bis-ethylene bis (oxy) 17o / - -methyl 11 / h- (4-methyl thiophenip) 19-nor pregn 9-ene (Example 32)
3.3-20.20 bis-Etipen bis (windows) 11 / i, 1bo / -dimethyl 19-nor pregn 9-ene (Example 33)
Calculated,%: C 82.81; H 7 Found,%: 82.6; H 7.3 UJl, +51 t 1.5 (C 0.95%, CHClj)
11 / 6- (4-Phenyl) phenyl 17 /} - 1-hydroxy 1 7 ° (- (prop-1-vinyl) estr 4,9-diene 3-one, mp 240 ° C, Mv +181 , 5 ± 3 ° (, СЦС1з)
11/3- (2-Metsh1 prop-1-enyl) 17/3 hydroxy 17th α-ethynyl estr 4,9-diene 3-one, m.p. 150 ° C
Calculated,%: C 82.24; H 8.63.
Found,%: C 82.1j H 8.5. d -212,5 t ЗСЧС 1%, СНС1з)
(3-Methoxyphenyl) 17 ° / - hydroxy 19-nor Preg 4,9-diene 3,20-wild, so pl. 173 ° С, U30 +108,51 ± 2,5 ° (, 5%, CHClj)
11 - Propsh 17o (-methyl 19pregna 4,9-diene 3,20-dione
m.p. 122 ° С
Calculated,%: C 81.31;
H 9.67
Found, Z: C 81.3; H 9,
  -105 ± 2 ° (,
CHClj)
(4-Methyl) thiophene1 171 -metsch1 19-nor pregn
4,9-diene 3-20-dione Calculated,%: C 77.37; H 7.88; S 7.38; Found: C, 77.6;
H 8.0; S 7.4
o (jo ± 4,5
(, 6%, CHClj)
11) 5. 16-Dimethyl
19-nor pregn 4,9-diene 3,20-dione, so pl. 155 ° C, R 0,26
3.3-20.20-ethylene bis (oxy) 1bx / - -methyl (4-methylthiophenyl) 19-norpregn 9-ene 5 (/ - ol (Example 34)
11 / g-cyclopropyl
3,3-ethylene bis (oxy) 17 ° ((prop--1-inip) estr 9-ene 5o (, 17 -diol (example 35)
3,3-Etsh1en bis (oxy) 11 / s- (4- -isopropylphenyl)
17 (/ - (prop-1-ynil) estr 9-en 5of, 17/5-diol (example 37)
3,3-ethylene bis (hydroxy) ..
11th (3-metsh1thiophenyl) 17of- (npon--1-ynyl) estr 9-en 5o, 17 -diol (Example 38)
3,3-ethylene bis
(oxy) (2- -propenyloxy) phenyl 1 7 (Y- (prop-1-vinyl) estr 9-ene 5 ° /, 17p-diol (Example 39)
3,3-ethylene bis
(oxy) en 2-yl, 17c / -methyl 5,21-di-hydroxy 19-yor
16 (; / - Methyl 1 1 /} - (4-methyl-1 h thiophenyl) 19-norpregn 4,9-diene 3, 20-dione Calculated: C 77.37; H 7.88i S 7 .38 Found: C 7.6; H 8.0 S 7.4. O (3p +290 ± 5 ° (C 0.6%, CHCl))
1 1 - Tsshslopropil 11jb- 2 h
-hydroxy 17 (Y- (prop-1– 30 min
- vinyl) estr 4,9-diene
3-he
Calculated,%: C 82.24;
H 8.63
Found,%: C 82.2; H 8.7
Rf 0,28
1 1 A- (4-Isopropyl) fenil 45 min 17 -hydroxy, (prop--1-insh1 (estr 4,9-diene 3-one, mp,) + 73 ± 2 (С 0.7% , СНС1з)
(3-methylthio) phenyl 1 h
1 7/1-hydroxy 17o (- (prop1-ynil) estr 4.9-dnane
3-he
Calculated,%: C, 77.73;
H 7.45
Found,%: C 77.7;
H 7.6
 +521 1.5 °,
(, СНС1з)
(2-Propenyloxy) 40 min
phenyl 17 3-hydroxy
17 in (- (prop-1 -fine) estr
4,9-diene 3-one
Calculated,%: C 81.41;
H 7.74 Found,%: C 81.7;
H 7.9.
L3d +52,51 2, 5 °
(, 7%, CHClj)
1 / & - Tiens1 7ii- tetsl 30 min 1-hydroxy 19-norpri
regn 4.9 (10) diene, 20-dione (Calculated,% :: C 73.3;
47
pregn 9-en 20-it (example 4O)
3,3-Ethylene bis (oxy) 11/3-cyclopentyl 17a - (prop-1-ynyl) estr 9-ene 5c {, 17/5-diol (Example 41)
20K-Acetoxy, 3,3-ethylene bis (oxy) (3-methoxyphenyl) 17 / -methyl 19-norpregn 9-ene 5 (-ol (Example 43)
3,3-ethylene bis (oxy)
1 1 / 3- 4 (3-methyl) butylthiophenyl 17c / - - (prop-1-ynyl) e p 9-en 5, 170-diol (Example 42)
1340593
48
Continued table. one
H 7.5; S 7.6 Found: C 73.13, H 7.36, S 7.81 Hs + 138, ..., 5 (, 57%)
11/5-Cyclopentyl 17 / g-hydroxy 17o / - (prop-1-vinyl) estr 4,9-diene 3-one
- /.
Calculated,%: C 82.49
H 9.05.
Found,%: C 82.2
H 9.3.
/ L + 122 ± 2.5 °.
(, 9%, CHClj)
20K-Acetoxy 11 / 9- (3-me
toxphenyl) 17o -methyl
19-norgn 4.9-diene
3-he, so pl.
Calculated,%: C 77.88;
H 8.28.
Found,%: C 77.6;
H 8.2.
to Jj + 168i- 2,5
(, CHClj)
11 / 5-4 (3-Methyl) butylthio phenyl 17 9-hydroxy 17o - (prop-1-ynyl) estr 4.9-dien 3-one
Calculated,%: C 78.62; H 8.25- S 6.56 Found: C 78.4; H 8.35, S 6.4. o (l, +133.5 ± 2.5 ° (, CHClj)
table 2
0.9 0.01 1 0.1 3.4 0.4 0.4 0.04 04.04 3.1 0.2, 01 -1 1.9 0.7 0.5 0.1 0.02 0.02 0.3 0.1 1.4 0.1 0.5 0.07 0.35 0.04
1.3 3274536
11.5 116080
9.60,363126 6.3 .12.4236910
7.72.033129 0.1 0.6108513
1.1 3.066230
1.6 38176
0.4119
6,48,23,6
5.64167
0.4
0.6
18
13
8.3 2.4 24 62
0.13 0.05 19 16
Table 3

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法律状态:

优先权:

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申请号 | 申请日 | 专利标题

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FR8203338A|FR2522328B1|1982-03-01|1982-03-01|NEW PRODUCTS DERIVED FROM THE STRUCTURE 3-CETO 4,9 19-NOR STEROIDS, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS|

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