• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    A cartridge (30) for storing a dosage of dry medicine (38) and for subsequent use with an intravenous administration set to facilitate administration of the dosage has a container (34) to hold the dry medicine (38), means (32) for connecting the cartridge (30) to the intravenous administration set so that liquid passing through the intravenous administration enters the container (34) and dissolves the medicine (38), and barrier means (42) disposed in the container (34) to prevent particles of the dry medicine (38) from passing out of the container (34).
    公开号:SU1184435A3
    申请号:SU823481624
    申请日:1982-08-25
    公开日:1985-10-07
    发明作者:Карвин Харрис Дейл；Уолтер Харгроув Вильям
    申请人:Эли Лилли Энд Компани (Фирма)；
    IPC主号:
    专利说明:

    ... one .
    The invention relates to medical technology, in particular to devices for storing a dose of a drug.
    A cartridge is known for storing a dry drug and dissolving it in a liquid, made of a moisture-proof material, within which a partition is installed to form two chambers, one of which serves to accommodate the dry drug, and the other has a channel for supplying liquid l.
    However, in this cartridge may penetrate into the solution of insoluble particles of the dry drug.
    The aim of the invention is to improve the quality of the finished drug by preventing insoluble particles of the dry preparation from entering the solution.
    To achieve this, a cartridge for storing a dose of a dry drug and dissolving it in a liquid made of a moisture-proof material has a partition inside it to form two chambers, one of which serves to place the cyxoro drug, and the other has a channel for supplying liquid the partition is fixed and made of filtering material, and the wall of the dry preparation chamber has an opening for air release, while a meme is installed in the opening wound izgidrofobnogo manufacturing a breathable material. The fluid supply channel may have a partition installed parallel to its walls for separate supply and discharge of fluid. I
    FIG. 1 depicts the proposed
    cartridge, cutJ in FIG. 2 is the same embodiment; FIG. 3 is the same, the second embodiment of J in FIG. 4 shows a cartridge in the infusion system j in FIG. 5 - chuck FIG. 3 with an adapter.
    The cartridge (FIG. 1) comprises a housing 1 made of a moisture-proof material. Inside the housing 1 there is a partition 2, made of filter material with the formation of two chambers 3 and 4, while the chamber 3 serves to accommodate a dry medication in it,
    352
    and chamber 4 has a channel 5 for supplying liquid. In the wall of the chamber 3 in the upper part of the hole. 6, in which a membrane 7 of hydrophobic air-permeable material is installed, for example, fluoroplastic. The housing 1 is made of a transparent thermoplastic (for visual observation) capable of undergoing
    sterilization.
    The cartridge shown in FIG. 2 also includes a housing 1, a fixed partition 2, dividing the internal volume of the housing by
    5 two chambers - chambers 3 and chamber 4. This cartridge has two channels 5 for supplying fluid, connected to the chamber 4. Each of chambers 3 and 4 has an opening 6 for air, into which. rum installed breathable membrane 7.
    The cartridge shown in FIG. 3 also has a housing 1 within which a partition 2, a chamber 3 for a dry preparation and a chamber 4 are located. Channel 5 for a liquid has a partition 8 for dividing it into channels 9 for separately supplying and discharging liquid. The cartridge has a 6 hole for
    0 exhaust air in which the membrane is placed 7.
    The cartridge shown in FIG. 1 operates in the system shown in FIG. 4 as follows.
    The cartridge is connected to the infusion system using channel 5. Since the liquid level of the container 10 is higher than that in the cartridge, the pressure of the liquid provides flow from the container 10 down through the dropper 11, the flexible tube 12, the Y-shaped connection 13 and upwards through the channel 5 building 1 . Since the partition 2 is permeable to air and liquid, the latter flows into chamber 3 and mixes with the dry preparation. Chamber 4 is fully filled as fluid pressure pushes air or other
    0 gaseous substances in the housing 1
    out through the air-permeable membrane 7 and the hole 6 in the housing. The dry preparation thus enters the system fluid and dissolves.
    5 The liquid solution with the drug flows through the septum 2 and out through the channel 5, the U-shaped joint 13 and the flexible tube 12 to the joint with an adjustable flow of fluid through the needle 14 to the patient's vein.
    In the system shown in FIG. 1 and 4, channel 5 provides two-way fluid flow. At higher rates of infusion, a higher specific gravity of the medical solution can provide a flow out under the influence of gravity, and when the solution flows down and out of the cartridge, it is replaced by the upper flow of fluid with a lower density from the container 10 thus keeping the cartridge filled part of the system. The flow rate of the solution from the cartridge can be determined for each solution by selecting the porosity of the partition 2 and the diameter of the channel 5
    By reducing the porosity of the septum 2, longer insertion intervals can be obtained, and by increasing its porosity, shorter intervals. The flow rate of the solution from the cartridge can thus be determined and adjusted by the design of the cartridge.
    The solution obtained in the cartridge can thus completely flow out of it and be administered to the patient.
    The cartridge depicted in FIG. 2 may be connected to the dropper 1 with the help of nozzles 16 and 17, or incorporated into the system shown in FIG. 4, while the cartridge operates in the same way as the cartridge in FIG. one.
    The cartridge shown in FIG. 3, is intended for day use with an adapter 18 with a socket into which the piercing means with channels 9 is inserted and connected to the system shown in FIG. 4. In this case, the cartridge operates in the system in the same way as the cartridge in FIG. one.
    The invention can be used to treat diseases that require periodic administration of high concentrations of actibiotics, which are a dry preparation. It can also be used in dP administration of cardiovascular drugs with different doses and different injection rates. This prevents solid insoluble particles from entering the solution. Since the preparations are administered directly from the package, they can be stored for a long time.
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    权利要求:
    Claims (2)
    [1]
    1. CARTRIDGE FOR STORING A DRUG DOSE OF A DRUG DRUG AND DISSOLVING IT IN A LIQUID, made of a moisture-proof material, inside of which there is a partition with the formation of two chambers, one of which serves to accommodate a dry drug, and the other has a channel for supplying liquid, characterized in that that, in order to improve the quality of the finished medicinal product by preventing insoluble particles of the dry preparation from entering the solution, the septum is fixed and made of a filter oval material, and the wall of the chamber for a dry preparation has an opening for air release, with EFM, a membrane made of a hydrophobic breathable material is installed in the hole.
    [2]
    2. Cartridge pop. 1, it is distinguished by the fact that the fluid supply channel has a partition installed parallel to its walls for separate supply and removal of liquid.
    类似技术:
    公开号 | 公开日 | 专利标题
    SU1184435A3|1985-10-07|Cartridge for dose of medicinal preparation and dissolving it in liquid
    US4465471A|1984-08-14|Intravenous administration system for dry medicine
    US4552555A|1985-11-12|System for intravenous delivery of a beneficial agent
    CA1207622A|1986-07-15|Drug administration device
    JP4235798B2|2009-03-11|In-line drug delivery pack with controllable diluent
    US5395323A|1995-03-07|Dissolution system
    US5024657A|1991-06-18|Drug delivery apparatus and method preventing local and systemic toxicity
    US4874366A|1989-10-17|Housing enabling passive mixing of a beneficial agent with a diluent
    US4439183A|1984-03-27|Parenteral agent dispensing equipment
    US3976068A|1976-08-24|Drug dispenser for use with intravenous feeding pump
    US4533348A|1985-08-06|In-line drug dispenser for use in intravenous therapy
    US4474574A|1984-10-02|Formulation dispenser for use with a parenteral delivery system
    US4511353A|1985-04-16|Intravenous system for delivering a beneficial agent
    US4548598A|1985-10-22|Parenteral agent dispensing equipment
    CA1257164A|1989-07-11|Drug release device
    FI75738C|1988-08-08|Parenteral fluid management system.
    CA1284072C|1991-05-14|Housing enabling passive mixing of a beneficial agent with a diluent
    US4871360A|1989-10-03|System for intravenous delivery of a beneficial drug at a regulated rates
    USRE34365E|1993-08-31|Intravenous system for delivering a beneficial agent
    US7632474B2|2009-12-15|Device, cartridge and method for solving powder in liquid, when manufacturing a dialysis fluid
    US4521211A|1985-06-04|Parenteral agent dispensing equipment
    US4740197A|1988-04-26|Intravenous system for delivering a beneficial agent via polymer delivery
    US4857052A|1989-08-15|Intravenous system for delivering a beneficial agent
    US4741734A|1988-05-03|Releasing means for adding agent using releasing means to IV fluid
    US4741735A|1988-05-03|Intravenous system for delivering a beneficial agent
    同族专利:
    公开号 | 公开日
    AU556380B2|1986-10-30|
    ES275292U|1984-10-16|
    GB2104862B|1985-01-16|
    IE53248B1|1988-09-14|
    PT75456B|1985-12-03|
    DK380882A|1983-02-27|
    DD202390A5|1983-09-14|
    IE822050L|1983-02-26|
    JPS5841566A|1983-03-10|
    EP0077604A1|1983-04-27|
    GB2104862A|1983-03-16|
    EP0077604B1|1986-06-04|
    IL66631D0|1982-12-31|
    RO85686A|1985-01-24|
    PT75456A|1982-09-01|
    FI822949L|1983-02-27|
    CA1187367A|1985-05-21|
    ES275292Y|1986-06-16|
    KR860000277B1|1986-03-26|
    AR229701A1|1983-10-31|
    GR76865B|1984-09-04|
    RO85686B|1985-01-30|
    AT20189T|1986-06-15|
    AU8756182A|1983-03-03|
    PH19329A|1986-03-18|
    PL238010A1|1983-02-28|
    FI822949A0|1982-08-25|
    NZ201684A|1985-05-31|
    PL133289B1|1985-05-31|
    HU187406B|1986-01-28|
    KR840000909A|1984-03-26|
    ZA826204B|1983-07-27|
    IL66631A|1985-12-31|
    DE3271558D1|1986-07-10|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    FR1122616A|1955-02-24|1956-09-11|Improvements to devices for transferring a liquid or pulverulent substance, in particular a therapeutic substance|
    US3857392A|1969-06-04|1974-12-31|Ims Ltd|Intravenous container with dislodgeable septum and dislodging piercer|
    DE2364414A1|1973-01-03|1974-07-11|Compaselect Gmbh|ADDITIVE AND PROCESS FOR PREPARING SOLUTIONS FOR INFUSION|
    US3976068A|1975-01-03|1976-08-24|Origo, Inc.|Drug dispenser for use with intravenous feeding pump|
    EP0005606A1|1978-05-12|1979-11-28|Vishnu Shanker Shukla|Improvements in and relating to apparatus for administering intravenous drugs|
    AU6249180A|1979-09-18|1981-04-09|Millipore Corp.|Automatic dual rate i.v. administration|JPS6083667A|1983-10-15|1985-05-11|Terumo Corp|Medical elastic sealer and medical drip set|
    US4573967A|1983-12-06|1986-03-04|Eli Lilly And Company|Vacuum vial infusion system|
    DE3463444D1|1984-02-03|1987-06-11|Ciba Geigy Ag|Drug dispenser for a parenteral administering system and a parenteral administering system equipped with such a dispenser|
    US4581014A|1984-04-03|1986-04-08|Ivac Corporation|Fluid infusion system|
    US4695272A|1984-10-26|1987-09-22|Aktiebolaget Hassle|Drug release device|
    EP0246715A3|1984-12-03|1988-02-03|BAXTER INTERNATIONAL INC. |Apparatus for the safe delivery of a beneficial agent to a patient|
    DE3585528D1|1984-12-03|1992-04-09|Baxter Int|HOUSING CAPABLE OF MIXING A MEDICINE WITH A DILUTION.|
    US4952210A|1985-12-13|1990-08-28|Becton, Dickinson And Company|Parenteral fluid administration set|
    EP0444761B1|1986-05-29|1994-02-02|Baxter International Inc.|Drug delivery apparatus having chamber with chimney|
    EP0435860B1|1986-05-29|1993-08-25|Baxter International Inc.|Adapter for connecting with a drug vial to introduce a beneficial agent to a patient|
    EP0436504B1|1986-05-29|1993-08-25|Baxter International Inc.|Receptacle for use in adding a beneficial agent to fluid in an administration set|
    IL82675A|1986-05-29|1992-08-18|Baxter Int|Drug delivery apparatus|
    SE461765B|1986-07-10|1990-03-26|Haessle Ab|DEVICE FOR RELEASE OF SUBSTANCE|
    US4786279A|1986-07-31|1988-11-22|Abbott Laboratories|Container for mixture of materials|
    ES1002629Y|1987-06-05|1989-01-16|Badia Marcelo Segura|CONNECTION FOR CATHETERS, PERFUSION EQUIPMENT AND LIQUID BOTTLES TO BE PERFUSED|
    FR2705575B1|1993-05-27|1995-07-28|Soludia|Method and device for producing a controlled concentration solution for medical use.|
    DK2042211T3|2001-06-29|2019-06-11|Coloplast As|catheter assembly|
    US7682353B2|2001-06-29|2010-03-23|Coloplast A/S|Catheter device|
    US7311698B2|2001-09-24|2007-12-25|Coloplast A/S|Urinary catheter assembly allowing for non-contaminated insertion of the catheter into a urinary canal|
    US9199029B2|2008-06-20|2015-12-01|Analytica Limited|Flushable injection port|
    CN103747831B|2011-08-29|2017-02-22|科洛普拉斯特公司|Catheter activation by handle removal|
    US9731105B2|2015-02-20|2017-08-15|Carefusion 303, Inc.|Micro infusion device for drug delivery|
    CN108403365B|2018-03-19|2019-07-30|重庆良护科技有限公司|A kind of medical instrument|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    US29633581A| true| 1981-08-26|1981-08-26|
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