• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    DISPOSABLE CENTRIFUGAL BLOOD PROCESSING SYSTEM Herbert M. Cullis A continuous flow centrifugal processing system for separating whole blood into fractional components includes a centrifugal separator unit having a molded bowl-shaped outer shell dimensioned to fit within a rotatably-driven casing on an associated centrifuge apparatus. A bowl-shaped inner shell disposed within the outer shell forms therewith athin separation channel radially spaced from the axis of rotation wherein fractions are separated from the whole blood under the influence of centrifugal force. A rotating seal carried on the processing chamber between ports in the chamber and the non-rotating portions of the system. The outer shell includes a relatively thin side wall portion which is inwardly biased toward a side wall portion on the inner shell when seated in the casing. A plurality of projections on the side walls limit inward deformation of the outer shell to maintain a very close concentric spacing between the shell members to facilitate rapid separation of blood flowing through the chamber. By reason of the shell members being molded, the processing chamber can be economically produced in large quantities for disposable one-time use.
    公开号:SU1072794A3
    申请号:SU772481957
    申请日:1977-05-13
    公开日:1984-02-07
    发明作者:Майерс Каллис Герберт
    申请人:Бакстер Травенол Лабораториз Инк (Фирма)；
    IPC主号:
    专利说明:

    The invention relates to equipment for the separation of biological fluids, in particular for the fractionation of blood. A known centrifuge for the separation of biological fluids, mainly blood, comprising a rotor comprising a housing with a lid, an insert inserted therein with a gap to form a separation chamber, a device for supplying the source liquid to the separation chamber, a device for draining the separated fractions containing radially located in the lid on various the distance from the axis of rotation of the hole and the chamber for collecting and removing the separated fractions in the upper part of the body, the width of which exceeds the width of the separation chamber formed by acrains last and insert. The housing and the inserts are made of metal 1. However, the centrifuge rotor, when reusable, must be disassembled, washed and sterilized, and the possibility of contamination of the biological fluid being separated is not excluded. The purpose of the invention is to simplify the operation of the centrifuge and prevent the contamination of the biological fluids being separated. This goal is achieved by the fact that in the centrifuge the rotor is provided with an elastic shell placed between the insert and the inner surface of the housing and repeating the last one, the insert is made of an elastic material, the insert or elastic shell having protrusions for fixing the gap between it. In FIG. 1 schematically depicts an elastic shell with a mouth insert, axonometric (with a partial cut-out); in fig. 2 - centrifuge rotor, longitudinal section; in fig. 3 - rotation of the rotor sealing unit in FIG. 4 - a chamber for collecting and discharging separated fractions (on an enlarged scale); in fig. 5 is a diagram of the position of pipelines and pumps. A centrifuge for the separation of biological fluids, mainly blood, includes a rotor containing a cup-shaped body 1, an insert 2, filled into an elastic material, an elastic shell 3 placed between the insert and the inner surface of the case, repeating the shape of the latter and forming an annular chamber with the outer surface of the insert py 4 separation. The lips 5 and 6 of the elastic shell and the inserts are attached by means of a tongue-and-groove joint to the flat lid 7 and form a chamber 8 for collecting and draining separated fractions that are wider than the width of the separation chamber. The rotor is equipped with a device for removing the separated fractions. It contains four holes 9 for removing red blood cells (Taurus), four holes 10 for tapping white blood cells (TUC) located in concentric circles. Each of the holes 9 is connected to a tube 11, which passes through the openings 12 in the lid 7 to the inside of the insert 2. In the same way, the openings 10 are connected to tubes 13 that pass through the openings 14 to the inside of the insert. A device for removal of separated fractions contains holes 15 for removal of plasma as it accumulates in chamber 8, made in the flange of insert 2. These holes are connected by means of tubes 16 to passage channels 17 in cover 7. Similarly, tubes 11 are connected to channels 18, and tubes 13 - with channels 19 in the lid. The device for supplying the liquid to be divided into the separation chamber comprises a tube 20 connected to the channel 21 in the lid 7 and has an opening 22 for the liquid to exit. In the bottoms 23 and 24 of the housing and the insert, holes 25 can be made, which serve for mounting, the inserts 2 or the elastic shell 3 have protrusions 26 for fixing an annular gap between them. The rotor is provided with a rotating sealing unit 27 mounted on the cover 7 along the axis of rotation of the rotor. using bolts 28. The assembly 27 (FIG. 3) contains a rotating disk 29 in which several annular recesses 30 are made, and a fixed element 31 in which several connections are made to annular recesses 32. Jumpers 33 are made to isolate the liquid between the corresponding recesses. In the lid 7, two passageways are formed for each annular undercut - associated with a specific fraction, and each of these passageways may be in turn associated with a Y-connector intended for this purpose and tubes with corresponding with a single orifice of one group, connected to a fraction (the compounds in Fig. 3 are not shown). I The fixed member 31 is pressed against the rotating disk 29 by. holding the lever 34 mounted on a centrifuge bed (not shown). The disk 29 can be attached to the lid 7 by means of concentric silastine O-rings and made of ceramic with a polished bottom surface, through which the fluid flows from the recess 30 to one of the channels 17, 18 or 19. The fixed sealing element 31 is made and stainless steel and lapped to disc 29 to ensure good contact. 1 Between them. The CCP withdrawal opening 9 is connected by a length of tube 35 to the peristaltic pump 36. The BKT discharge opening 10 is connected by a section of tube 37 with a peristaltic pump 38, and the opening 15 for removal of plasma is connected by a cut 39 of the pipe to the peristaltic pump 40. Blood is supplied to the rotor. tube 41, to which acid citrate destrasis igargar flows through tubes 42 and 43, peristaltic pump 44. To isolate the saline solution, it is fed into the rotating sealing unit 27 by means of a length of tube 45 and removed through tube 46. In order to lubricate the saline solution is fed to the seal by means of a segment of tube 47 and a peristaltic pump 48. Tubing, CCT and plasma, withdrawn by the system, can be pumped to the appropriate group of collectors for storage, or, if necessary, returned to the donor. To protect against air leaks due to excessive temperature increase or blockage of the donor's vein, various safety features can be included in the system. The rotor body 1 (Fig. 2} is mounted on the drive shaft 49, which is driven by the engine 50. The centrifuge operates as follows. The rotor is driven at 800 rpm. Then sterile saline and all air are passed the bubbles are removed by backwashing using a peristaltic pump 38. Blood flows through the tube 41, the rotating, sealing unit 27 and the tube 20 to the opening 22 to flow in the direction of the radius outward into the separation chamber 4. and blood along the lateral surface of the shell .3 and insert 2 in the direction of the groups of holes 10 and 15, while the blood eventually separates into three concentric O6i5ychs, the most dense QCTs are most removed, then in the middle of the BKT or intermediate layer having a smaller Llot and at the shortest radius of the plasma, which has the lowest density. Platelets are usually distributed in all three areas, but with a change in centrifuge speed, some of them can be concentrated. By means of groups of holes 9, 10 and 15, the components are removed from 4 and, depending on the requirements, can be assembled or returned to the donor. Usually the flow rate of whole blood in. chamber 4 is such that the residence time of the blood in it is about 3 minutes. To ensure that the blood components are separated in the chamber, it is necessary that chamber 4 be very small — on the order of 1.5 mm or less. In order to effectively separate blood components, this size must be maintained so that exact concentricity is ensured and the components after their separation go upwards into chamber 8 to collect and discharge separated fractions, the necessary width of separation chamber 4 is fixed by means of protrusions 26 located at a certain distance from each other. In order to ensure that the protrusions really determine the distance between the elements, the elastic sheath 3 is dimensioned so that when it is installed in the case 1, the side walls of the elastic sheath are slightly deformed inside. This deformation is sufficient for the projections located at a certain distance from one another to contact the surface of the opposite wall and is a guarantee that the required clearance is established and preserved. To ensure the installation of the elastic sheath 3. with the insert 2 into the body 1, it is preferable to manufacture the outer surface of the elastic sheath with a small taper, usually in the order of one degree. Internal surface of the case. 1 is also conic. The elastic shell 3 and the insert 2 are pre-molded from polycarbonate plastic, for example Lexan (trademark of General Plastic Corporation.), According to the conventional molding technology. The internal cavity of the insert 2 can be filled with foam 51. Other plastics, such as methyl methacrylate, styrene acrylonitrile, acryl, styrene or acrylonitrile, can be used to make the elastic shell and other parts that come into contact with blood besides polycarbonate. Shells can be made by molding, as well as by vacuum processing or casting. The elastic sheath 3, the insert 2 and the lid 7 attached thereto form a single unit, which is easily inserted into the rotor housing 1 and removed from it. After splitting the blood sample i, this node is replaced by
    another, which prevents the separated liquid from being contaminated by another liquid, which was separated before, and
    allows you to simplify the operation of the centrifuge, since it is not necessary to rinse and sterilize the rotor.
    Fizgum zutteotiHi pacmSi
    权利要求:
    Claims (1)
    [1]
    CENTRIFUGA FOR SEPARATION OF BIOLOGICAL LIQUIDS, mainly blood, including a rotor containing a housing with a cover, a gap installed therein to form an separation chamber, a device for supplying the initial liquid to the separation chamber, a device for removing separated fractions, containing a number of radially located in the cover * at different distances from the axis of rotation of the holes and the chamber for collecting and removing separated fractions in the upper part of the casing, the width of which exceeds the width of the separation chamber, is clear m, that, in order to simplify the operation of the centrifuge and prevent contamination of the separated biological fluids, the rotor is equipped with an elastic shell located between the insert and the inner surface of the housing and repeating the shape of the latter, the insert is made of elastic material, the insert or elastic shell having protrusions for fixing the gap between them. ' m SU 1072794
    FIG. Ϊ
    类似技术:
    公开号 | 公开日 | 专利标题
    US4636193A|1987-01-13|Disposable centrifugal blood processing system
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    US4120448A|1978-10-17|Centrifugal liquid processing apparatus with automatically positioned collection port
    SU1072794A3|1984-02-07|Centrifuge for separating biological liquors
    SU1058490A3|1983-11-30|Centrifuge for separating blood in fractions
    US3519201A|1970-07-07|Seal means for blood separator and the like
    US4146172A|1979-03-27|Centrifugal liquid processing system
    US4007871A|1977-02-15|Centrifuge fluid container
    US5100372A|1992-03-31|Core for blood processing apparatus
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    US4059108A|1977-11-22|Process for pheresis procedure and disposable pheresis bowl therefor
    US4430072A|1984-02-07|Centrifuge assembly
    IE42342B1|1980-07-16|Centrifuge separation and washing device and method
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    US4790807A|1988-12-13|Centrifuge arrangement
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    CA1068658A|1979-12-25|Disposable centrifugal blood processing system
    GB1569219A|1980-06-11|Disposable centrifugal separator
    CA1068657A|1979-12-25|Disposable centrifugal blood processing system
    同族专利:
    公开号 | 公开日
    DE2717344A1|1977-11-24|
    NO771540L|1977-11-15|
    CH624023A5|1981-07-15|
    NO146848B|1982-09-13|
    NL7705334A|1977-11-16|
    SE7704127L|1977-11-15|
    IL51629D0|1977-05-31|
    JPS52138761A|1977-11-19|
    SE427138B|1983-03-07|
    DE2717344C2|1987-02-05|
    FR2350885B1|1982-06-11|
    JPS6050497B2|1985-11-08|
    IT1084675B|1985-05-28|
    CA1057254A|1979-06-26|
    NO146848C|1982-12-22|
    IL51629A|1979-11-30|
    FR2350885A1|1977-12-09|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    UST955355I4|1959-06-24|1900-01-01|
    US3489145A|1966-08-08|1970-01-13|Surgeon General Of The Public|Method and apparatus for continuous separation of blood in vivo|
    US3655123A|1966-08-08|1972-04-11|Us Health Education & Welfare|Continuous flow blood separator|
    US3519201A|1968-05-07|1970-07-07|Us Health Education & Welfare|Seal means for blood separator and the like|
    DE2353227A1|1973-10-24|1975-05-07|Rohe Scientific Corp|SAMPLE CONTAINERS FOR USE IN CENTRIFUGATION|
    US4059108A|1974-08-15|1977-11-22|Haemonetics Corporation|Process for pheresis procedure and disposable pheresis bowl therefor|
    US3955755A|1975-04-25|1976-05-11|The United States Of America As Represented By The United States Energy Research And Development Administration|Closed continuous-flow centrifuge rotor|US4094461A|1977-06-27|1978-06-13|International Business Machines Corporation|Centrifuge collecting chamber|
    JPS5819344B2|1979-02-26|1983-04-18|Terumo Corp|
    US4344560A|1979-11-02|1982-08-17|Asahi Kasei Kogyo Kabushiki Kaisha|Container, apparatus and method for separating platelets|
    US4389206A|1980-10-09|1983-06-21|Baxter Travenol Laboratories, Inc.|Centrifugal processing apparatus and rotatable processing bowl apparatus|
    GB8521867D0|1985-09-03|1985-10-09|Fisons Plc|Centrifuge|
    US4834890A|1987-01-30|1989-05-30|Baxter International Inc.|Centrifugation pheresis system|
    US4939087A|1987-05-12|1990-07-03|Washington State University Research Foundation, Inc.|Method for continuous centrifugal bioprocessing|
    DE19728089A1|1997-07-02|1999-01-07|Fresenius Ag|Cell suspension separation|
    DE19810195A1|1998-03-10|1999-09-23|Reinhard Salinger|Specific blood product extracted from patient blood using a laminar flow system|
    IT1311989B1|1999-03-30|2002-03-22|Giammaria Sitar|PROCEDURE FOR ISOLATING FETAL CELLS PRESENT IN THE PERIPHERAL BLOOD.|
    US6500107B2|2001-06-05|2002-12-31|Baxter International, Inc.|Method for the concentration of fluid-borne pathogens|
    US20060226087A1|2005-04-08|2006-10-12|Mission Medical, Inc.|Method and apparatus for blood separations|
    WO2009113247A1|2008-03-12|2009-09-17|山科精器株式会社|Centrifugal separator|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    US68729076A| true| 1976-05-14|1976-05-14|
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