• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The present invention provides an antacid material based on magnesium aluminium hydroxide and a process for the preparation of an antacid material based upon magnesium aluminium hydroxide, wherein magnesium hydroxide and/or magnesium oxide is reacted with an aqueous solution of aluminium sulphate, in an atomic ratio of magnesium to aluminium of 1:1 to 3:1, until the pH of the reaction mixture is from 4.0 to 8.0, whereafter water-soluble components are removed from the mixture which is isolated and, if descired, dried. The present invention also provides pharmaceutical compositions containing an antacid material prepared by this process, in admixture with a conventional pharmaceutical adjuvant. The antacid material has advantageous characteristics, e.g. an effective buffering action on gastric juices and stability.
    公开号:SU1056876A3
    申请号:SU813291150
    申请日:1981-05-13
    公开日:1983-11-23
    发明作者:Кнехт Адольф；Шнейдер Михаэль
    申请人:Гедеке Аг (Фирма)；
    IPC主号:
    专利说明:

    SP
    O5 00
    s |
    The invention relates to the preparation of an antacid based on compounds of magnesium and aluminum, in particular to methods for obtaining an acidide based on hydroxides and sulfates of magnesium and aluminum. A known method for producing an antacid based on magnesium and aluminum hydroxides, is that magnesium hydroxide with aluminum hydroxide gel has a molar ratio of 1: suspended in water. About the technical essence and the achieved result, the invention is a method of obtaining an antacid. the basis of hydroxides and sulphates of magnesium and aluminum, which consists in the fact that aluminum sulphate is subjected to interaction with alkaline earth metal carbonate in an experimental medium at pH 7-5.5 and the atomic ratio of magnesium to aluminum equal to 1: +, 6-6,0, followed by separation of the obtained product 2J. A disadvantage of the known methods is that the storage stability of the antacid is unsatisfactory. The aim of the invention is to increase the storage stability of the antacid produced. According to the method of obtaining an antacid based on hydroxides and sulphates of magnesium and aluminum by the interaction of aluminum sulphate with magnesium compounds in an aqueous medium and afterwards 35 to isolate the product obtained, e magnesium compound used hydroxide and / or oxide ma1- audio and the process is conducted at an atomic ratio of magnesium to aluminum is equal to (1-3): 1 until the pH of the medium, 08, 0. The invention is illustrated by examples in which the acid binding capacity of the products is determined according to K Schaub after storage for 3 Mea, and one year at room temperature. In this case, the time during which the product is buffered is indicated for buffering within the range, since the product is the more active, the Longer the pH of the medium is in the range of 3-5. . PRI me R 1. 8 g of HjO f0 (024 moths of aluminum), while stirring, dissolve the k2 ml species when heated to. 2 g of magnesium hydroxide (0.03 mol magnesium) suspended in 30 ml of water, intensively stirred, are slowly added to the aluminum sulfate solution. After the addition of the magnesium hydroxide suspension is completed, the reaction mixture, in which the atomic ratio of magnesium to aluminum is 1.1: 1, stirred until the pH of the aqueous suspension is equal. The mixture is then filtered on a glass frit under reduced pressure and washed twice with 50 ml of water. After filtration, the precipitate is dried first at room temperature and dried for 3 hours at a yield of 3.0 g of the composition: 0.02 mol of aluminum, 0.005 mole of magnesium, 0.006 mole of sulphate, the rest is hydroxyl ions and water, Buffer time of product yield: no. in the table, PRI me R 2o 1 kg of magnesium hydroxide (17.15 mole of magnesium) is suspended in 14 kg of water To this suspension, stirring, add 12 kg, obtained at a solution of k kg L1, (60) 18H20 aluminum) in 21 liters of water. The atomic ratio of magnesium to aluminum is 1.43: 1. The mixture is stirred for 3 hours until the pH of the medium is 5.8. Then the reaction is performed. the mixture is filtered under reduced pressure, washed twice with 15 liters of water and air-dried. The yield is 3.5 kg of the product of the composition: 11.5 mol of aluminum, 2.63 mol of magnesium, 2.7 mol of sulfate, the rest hydroxyl ions and water .. The time of buffering is indicated in the table, Example 3. 22.3 g of Al2 (50) j ISH-O (0.669 moles are dissolved in 750 g of water. Then, while stirring, pour 60 g of powdered magnesium hydroxide (1.03 mole of magnesium Then the mixture, in which the atomic ratio of magnesium to aluminum is 1.54: 1, is stirred until a pH of 4.7 is reached. The precipitate is filtered as before Apply pressure on the glass frit, wash with 20.0 ml of water and then air dry.The yield is 480 g of the product of the composition: 0.705 mol of aluminum, 0.534 mol of magnesium, 0.557 mol of sulfate, the rest is hydroxyl ions and water. Table 4. Example 4. 39 g of magnesium oxide (0.775 mol of magnesium) are suspended in 0.5 l of water o The suspension obtained is added to the suspension; while mixing, the rasteor is added. 240 g
    权利要求:
    Claims (1)
    [1]
    METHOD FOR PRODUCING ANTACID ON THE BASIS OF HYDROXIDES AND SULPHATES OF MAGNESIUM AND ALUMINUM by reacting aluminum sulfate with a magnesium compound in an aqueous medium and subsequently isolating the resulting product, which τη is based on the fact that in order to increase stability during storage of the obtained product, hydroxide is used as magnesium compound and / or magnesium oxide and the process is carried out at an atomic ratio of magnesium to aluminum equal to (1-3): 1, until the pH of the medium reaches 4.0-8.0.
    SP 05 QO M f
    1 stitching, slowly add to the solution of aluminum sulfate. “After the addition of the suspension of magnesium hydroxide, the reaction mixture in which the atomic ratio of magnesium to aluminum is 1.41: 1 is stirred until the pH of the aqueous suspension is 5.5. Then the mixture is filtered on a glass frit under reduced pressure and washed twice with water in an amount of 50 ml,
    After filtration, the precipitate was dried first at room temperature and then for 4 hours at 6 ° C.
    The yield is 3.0 g of the product 'composition: 0.02 mol of aluminum, 0.005 mol of magnesium, □, 006 mol of sulfate, the rest is hydroxyl ions and water. The buffering time of the product is indicated in the table.
    Example 2 about 1 kg of magnesium hydroxide (17.15 mol of magnesium) is suspended in 14 kg of water. To this suspension, stirring, add a solution of 4 kg Α1, (ύΟ ^) 3 · 18Н 2 0 (12 moles of aluminum) in 21 liters of water, obtained at 6 ° C. At the same time, the atomic ratio of magnesium to aluminum is 1.43: 1 ·. The mixture is stirred for 3 hours until a pH of 5.8 is reached. Then the reaction. the mixture is filtered under reduced pressure, washed twice with 15 L of water and dried in air. The yield is 3.5 kg of product composition: 11.54 mol of aluminum, 2.63 mol of magnesium, 2.76 mol of sulfate, the rest is hydroxyl ions and water. The buffer action time is indicated in the table.
    Example 3. 22.3 g of Al ^ iSO ^ j * 18H (0.669 mol) was dissolved in 750 g of water. Then, while stirring, 60 g of powdered magnesium hydroxide (1.03 mol of magnesium} are added, and then a mixture in which the atomic ratio of magnesium to aluminum is 1.54: 1 is stirred until a pH of 4.7 "is reached.
    The precipitate was filtered under reduced pressure on a Glass Frit, washed with 20.0 ml of water and then dried in air. The yield is 480 g of a product with the composition: 0.705 mol of aluminum, 0.534 mol of magnesium, 0.557 mol of sulfate, the rest is hydroxyl ions and water. The buffering time of the product is indicated in the table.
    Example 4. 39 g of magnesium oxide (0.775 mol of magnesium) are suspended in 0.5 l of water. To the resulting suspension, stirring, add a solution of .240 g is a preservation of 1 1056876
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    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    GB933405A|1960-07-01|1963-08-08|Keystone Chemurgic Corp|Hydrated magnesium aluminate|
    US3239416A|1963-05-29|1966-03-08|Armour Pharma|Aluminum hydroxide-metal hydroxide antacid and process of making the same|
    JPS5120997B2|1971-12-25|1976-06-29|
    GB1363399A|1972-04-13|1974-08-14|Rotta Research Lab|Method of preparing an antacid pharmaceutical product|
    US4105579A|1976-03-04|1978-08-08|Barcroft Company|Process for producing pharmaceutical grade aluminum hydroxide gels|USRE34164E|1974-03-30|1993-01-19|Aluminum Company Of America|Synthetic hydrotalcite|
    US4904457A|1974-03-30|1990-02-27|Aluminum Company Of America|Synthetic hydrotalcite|
    DE3408463C2|1984-03-08|1987-02-26|Giulini Chemie Gmbh, 6700 Ludwigshafen, De|
    US4869902A|1984-04-19|1989-09-26|Rorer Pharmaceutical Corporation|Antacid composition|
    DE3429263A1|1984-08-08|1986-02-20|Gödecke AG, 1000 Berlin|Process for the stabilisation of filterable antacids with hexitols|
    US4656156A|1986-01-21|1987-04-07|Aluminum Company Of America|Adsorbent and substrate products and method of producing same|
    US5013560A|1989-03-17|1991-05-07|The Procter & Gamble Company|Microbially-stable bismuth-containing liquid pharmaceutical suspensions|
    GB2514840A|2013-06-07|2014-12-10|Imerys Minerals Ltd|Compositions for bleaching pulps and their use|
    US9711804B2|2013-07-08|2017-07-18|Phinergy Ltd.|Electrolyte regeneration|
    CA2945590C|2014-04-13|2019-06-11|Alcoa Inc.|Systems and methods for regeneration of aqueous alkaline solution|
    WO2018229789A1|2017-06-12|2018-12-20|Council Of Scientific & Industrial Research|An inorganic base antacid compound with improved and novel properties|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    DE3019032A|DE3019032C2|1980-05-19|1980-05-19|Magnesium aluminum hydroxide based antacid active ingredient, its manufacture and use|
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