• 专利附录
  • 专利说明
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    • 专利摘要:
    The invention relates to an emulsion of water and oil containing a solution of silicic acid and one or more stabilizing compounds in water, and one or more block copolymers as emulsifier. In addition to water in oil and oil in water emulsions, the invention also offers co-emulsions of water with silica in oil in water, water in oil in silica with water and oil in water with silica in oil. The emulsion or co-emulsion preferably contains, in addition to silicic acid, one or more other active substances which are soluble in oil and / or water. The stable emulsions with silicic acid according to the invention can advantageously be used as a medical or cosmetic agent, food supplement, liquid fertilizer, crop protection agent, biocide, biostimulant, plant nutrient, soil conditioner, catalyst, antioxidant or household product.
    公开号:NL2017436A
    申请号:NL2017436
    申请日:2016-09-08
    公开日:2017-03-16
    发明作者:
    申请人:Bio Science B V；
    IPC主号:
    专利说明:

    Emulsions containing silicic acid
    The invention relates to an emulsion of water and oil. The invention further relates to a method for preparing such an emulsion and its uses.
    There is a great need for silica in stable form. Silicic acid is used as an active substance for living organisms, such as people, animals, plants and aquatic organisms for very broad purposes, such as: - maintaining healthy and strong bones, skin, hair, nails; synergy with other active substances; distribution of other active substances by bodies; antioxidant for heavy metals; against biotic and abiotic stress; for promoting growth.
    Silicon is a common mineral in the earth's crust. It has a strong affinity with oxygen whereby silicon forms silica and silicates in reaction with oxygen, which are the most common soil minerals. These forms of silicon are very stable, so that they do not degrade rapidly in the biological system, with the result that soluble and biologically absorbable silicon is present in nature at very low concentrations.
    Silicic acid is a general name for the SiO2.nH2O silicon compound family, such as n = 2 Si (OH) 4 in basic solution. Soluble and biologically absorbable silicon is present in very low concentrations in nature, at a pH of <9 below 2 mM mainly in the form of monomeric silicic acid, above which polymerization takes place. However, a concentration of 2 mM is too low to use this substance as an additional food source in the form of, for example, food supplements. Therefore, a higher concentration of monomeric silicic acid, which can be prepared via a chemical synthesis, is desirable. However, a highly concentrated solution of silicic acid must be stabilized to prevent the particles from growing into poorly soluble and poorly bio-absorbable silicon compounds. The Chemistry of Silica (1979) describes the stabilization process on pages 323 to 327 - inter alia by means of steric stabilization (in which a non-ionic polymer, such as polyethylene glycol, is adsorbed on the surface of silicic acid molecules) and polar compounds as for example quaternary ammonium salts (such as carnitine, betaine and choline) - to prevent polymerization.
    A number of syntheses are known with which silicic acid can be produced industrially. Two known syntheses are described in The Chemistry of Silica (1979), 5 and 179: acid-base reaction with (sodium) silicate and hydrochloric acid, and hydrolysis of silicon tetrachloride.
    In the synthesis of silicic acid, it is almost impossible to obtain 100% monomeric silicic acid. Monomeric silicic acid does not react or reacts very weakly with metals, but larger silicic acid compounds such as dimers, trimers, oligomers, polymers and colloids that are always present after silicic acid synthesis react more strongly.
    The affinity of silicic acid with other substances in aqueous solutions poses a problem in a number of areas: in reaction with silicic acid, phosphorus and boron form Si-O-P (silicon phosphate) and Si-O-B (silicon borate) compounds; in an aqueous solution at low pH, monomeric silicic acid stimulates the oxidation of Fe 2+ to Fe 3+ and forms a complex with SiO 2 .NH 2 O. Calcium and magnesium also form complexes with silicic acid and molybdenum forms a complex into silica molybdate.
    Because silicic acid reacts with other substances, and complexes of silicic acid with additional active substances are undesirable in food supplements, liquid fertilizers, medicines, cosmetic products, etc. it is necessary to isolate other active substances and the silicic acid from each other so that interaction is prevented.
    The present invention has for its object to provide a solution of silicic acid in which this solution shows no gel formation, remains stable over a long period of time, does not react with other compounds and can therefore be used inter alia as a medical or cosmetic agent, or as a food supplement.
    In order to achieve the intended object, the invention provides an emulsion of the type mentioned in the preamble, characterized in that it essentially comprises a solution of silicic acid, one or more stabilizing compounds in water and, as an emulsifier, one or more block copolymers; preferably one or more W / O or O / W block copolymers consisting of two or more units selected from: non-ionic structural units selected from the group consisting of: alkylene such as 1 - 12 C alkylene, in particular methylene, ethylene, propylene and butylene, 1 - 12C alkylene oxide such as ethylene oxide, propylene oxide and butylene oxide, glycol, styrene, pyrrole, tetrahydrofuran, glycolide, butadiene, isoprene, ethylene ranutylene, glycerol, amine-containing units such as ethyleneimine and ethane diamine, sorbitol, alkylphenol, alkanol such as 1 - 12 C alkanol especially methanol, ethanol, propanol, butanol and isotridecanol, ether such as 1 - 12 C alkyl ether, in particular methyl, ethyl, propyl and butyl ether, cetyl, lauryl, oleyl and stearyl ether, phenol in particular alkyl phenol such as 1 - 12 12 C alkyl, preferably nonylphenol, sarcosine such as oleoyl sarcosine, lanolin, lactide, caprolactone, castor oil and amino acid; ionic structural units selected from the group consisting of: acrylic acid, acrylate, methacrylic acid, methacrylate, propoxylate such as glycerol propoxylate, taurate such as sodium N-methyl oleoyl taurate, stearate such as sorbitol stearate, sorbitol oleate, laurate such as sorbitol laurate, sulfonate such as ammonium dodecylbenzenate sulfonate such as calcium alkyl aryl sulfate and ethyl dimonium ethosulfate, especially tallow ethyl dimonium ethosulfate and phosphate such as trialkyl phosphate, especially tridecylosfate.
    Examples of a non-ionic W / O or O / W copolymer according to the invention are polyalkylene oxide block copolymer, block copolymers of polyethylene glycol and polypropylene glycol, and of poly lactic-co-glycolic acid (PGLA), polystyrene block block poly (ethylene-ran-butylene) -block polystyrene and nonionic surfactants in the form of block polymers.
    Examples of an ionic W / O or O / W block copolymer according to the invention are the diblock copolymer of styrene and methyl methacrylate and anionic surfactants in the form of block polymers.
    In a special embodiment, the emulsion contains one or more active substances in addition to silicic acid. In particular, the silicic acid solution has a pH of 0-12, preferably 0-9, more preferably 0-7, further preferably 0-5, particularly preferably 0-2.
    The stabilizing compounds preferably have electrostatic or steric properties. The stabilizing compounds with electrostatic properties are preferably polar compounds, more preferably quaternary ammonium salts such as trialkyl hydroxyalkyl ammonium compounds, for example one or more selected from the group consisting of choline, carnitine and betaine and salts thereof. Preferably, stabilizing compounds with steric properties are hydrogen adsorbing agents such as one or more selected from the group consisting of polysorbate, vegetable gum, cellulose, polyglycerol esters, polyethylene glycol, dextrose, propylene glycol, pectin and sugars.
    In particular, the invention provides an emulsion according to the invention in which the aqueous solution of silicic acid is emulsified with one or more W / O block copolymers in the oil to form a W / O (water in oil) emulsion. These one or more W / O block copolymers are preferably selected from the group described above.
    The invention also provides an emulsion according to the invention in which the oil is emulsified with one or more O / W block copolymers in the solution of silicic acid in water to an O / W (oil in water) emulsion. These one or more O / W block copolymers are preferably selected from the group described above.
    The invention then provides an emulsion according to the invention in which the W / O emulsion, in water without silicic acid, is emulsified to a Wsi / O / W (multiple or co-emulsion of a water with silicic acid in oil emulsion, in water emulsion). In particular, the water without silicic acid in the Wsi / O / W emulsion contains water-soluble active ingredients. These water-soluble active substances are preferably selected from one or more of the water-soluble salts of potassium, calcium, magnesium, iron, copper, manganese, molybdenum, boron and hydrophilic / lipophilic active substances such as water-soluble compounds of vitamins, minerals, microorganisms, plant extracts, algae, fatty acids, pharmaceutical substances, plant protection products, biocides, enzymes, hormones and cosmetically active substances. The aqueous phase with silicic acid in a co-emulsion with two water phases is referred to as Wsi in this application.
    The invention further provides an emulsion in which the O / W emulsion according to the invention is emulsified in oil to an O / W / O emulsion, a so-called O / W / O co-emulsion, with two oil phases. In particular, the oil or optionally both oil phases contains oil-soluble active substances, preferably one or more selected from the group consisting of zinc oxide, calcium borate, manganese carbonate, magnesium carbonate, magnesium hydroxide, ammonium molybdate and hydrophobic active substances such as oil-soluble compounds of vitamins, minerals, microorganisms, plant extracts, algae, fatty acids, pharmaceutical substances, plant protection products, biocides, enzymes, hormones and cosmetically active substances.
    Preferably, one or both of the oil phases of the emulsion according to the invention are selected from the group consisting of vegetable, animal, including fish oil, essential and essential oils.
    Depending on the application, one or both of the oil phases of the emulsion according to the invention are, for example, a vegetable oil such as selected from one or more of almond oil, argan oil, avocado oil, beh oil, borage oil, cocoa butter, grape seed oil, hazelnut oil, hemp oil, jatropha oil , cottonseed oil, coconut oil, krappa oil, linseed oil, macadamia oil, corn oil, olive oil, palm oil, palm kernel oil, peanut oil, rapeseed oil, rice germ oil, sacha inchi oil, safflower oil, sesame oil, soybean oil, wheat germ oil, evening primrose oil, walnut oil, cannaboli oil, sunflower oil, sunflower oil and cannabis oil.
    For emulsions intended for 'green' plant protection products, one or both oil phases are preferably an essential oil such as selected from one or more of lemon grass (Cimbopogon citratus), Eucalyptus globulus, rosemary (Rosmarinus officinalis), vetiver (Vetiveria zizanoides), cloves ( Eugenia caryophyllus) and thyme (Thymus vulgaris), peppermint (Mentha piperita), pennyroyal (Mentha pulegium), spearmint (Mentha spicata), basil (Ocimum basilicum), Artemesia vulgaris, Melaleuca leucadendron, Pelargonium roseum, Lavandulainnomum arifumumumumum, Lavandulaum arifumum zeylanicum, Lavandula angustifolia syn. L. officinalis, Tanacetum vulgare, Rabdosia melissoides, Acorns calamus, Eugenia caryophyllata, Ocimum species, Gaultheria procumbens, Cuminum cymium, Bunium persicum, Trachyspermum ammi, Foeniculum vulgare, Abelmoschus moschatus, Cedrus species, Pardan cogopogon, Cogogus, Cogogonus, Cogogonus, Cogonus, Cogonus, Cogonus, Cogonus, Cogonus, Cogonus, Ciperopia ), lemon (Citrus limon), rose (Rosa damascena), lavender, vetiver (Vetiveria zizanioides), catnip (Nepeta cateria), Trachyspermum species, Ocimum sanctum, Satoreja hortensis, Thymus serpyllum, Origanum creticum, Ageratum conyzoides, Aegle marmelos, dill oil (dill plant (Anethum sowa)), dillapiole, Anethum graveolens, spearmint oil (Mentha spicata), Curcuma longa, cucumber and ginger oil, take oil.
    For cosmetic emulsions, one or both oil phases are preferably an essential oil such as selected from one or more oils made from Pimpinella anisum, Ocimum basilicum, Citrus bergamia, Betula lanta, Satureja hortensis, Artemisia vulgaris, Juniperus virginiana, Cupressus sempervirens, Citrus limonum, Cymbopogon nardus, Pinus sylvestris, Anethum graveolens, Eucalyptus globulus, Zingiber officinale, (Geranium) Pelargonium odorantissimum, hyssop (Hyssopus officinalis), St. John's oil (Hypericum perforatum), juniper (Juniperus communis), kajeput (Campaleuca) kamduca (kamaleuca) kamducadena officinarum), chamomile (Matricaria chamomilla), cinnamon (Cinnamomum zeylanicum), cardamom (Elletaria Cardamommum), coriander (Coriandrum sativum), clove (Syzygium oromaticum), laurel (Laurens nobilis), lavender (Lavendula officinalis), lime lime symbol, limopogon citatus , lime (Citrus aurantifolia), mandarin (Citrus reticulata), marjoram (Origanum majorana), myrrh (Commiphora myrrha), myrtle e (Myrtus communis), niaoli (Melaleuca viridiflora), nutmeg (Myristica fragrans), oregano (Origanum vulgare), palmarosa (Cymbopogon Martini Motia), patchouli (Pogostemon patchouli), peppermint (Mentha piperita), rosewood (Aniba rosaeemaria) (Rosmarinus officinalis), sage (Salvia officinalis), sandalwood (Santalum album), sassafras (Sassafras officinalis), clary sage (Salvia sclarea), orange (Citrus aurantium dulcis), teatree (Melaleuca alternifolia), terpetine (Pinus resin, Pinus pinaster) , thyme (Thymus vulgaris), fennel (Foeniculum vulgare), vetiver (Vetiveria zizanoedes), incense (Boswellia carterii), carrot seed (Daucus corota), Ylang-Ylang (Cananga odorata), fir (Abies alba), black pepper (Piper nigrum ).
    Active substances in oils which can be used in particular in the emulsions with one or more oil phases according to the invention are: terpenes (hydrocarbons) such as myrcene, pinene, terpene, limonene, pcymene, alpha and beta-phellandrene, etc., and terpenoids (oxygen-containing hydrocarbons) such as acyclic monoterpene alcohols (geraniol, linalool), monocyclic alcohols (menthol, 4-carvomenthenol, terpineol, carveol, borneol), aliphatic aldehydes (citral, citronellal, perillaldehyde), aromatic phenols, carrole, thymol, safol eugenol), bicyclic alcohol (verbenol), monocyclic ketones (menthon, pulegon, carvon), bicyclic monoterpenic ketones (thujon, verbenon, fenchon), acids (citronellic acid, cinnamic acid) and esters (linalyl acetate), oxides (1,8-cineole) ), sulfur-containing compositions, methyl anthranilate, coumarins and sesquiterpenes (C15).
    The invention then provides an emulsion in which an emulsion of a solution of water optionally with one or more active substances as selected from the group consisting of water-soluble salts of potassium, calcium, magnesium, iron, copper, manganese, molybdenum, boron and hydrophilic / lipophilic active substances such as water-soluble compounds of vitamins, minerals, microorganisms, plant extracts, algae, fatty acids, pharmaceutical substances, plant protection products, biocides, enzymes and cosmetic active substances, in oil optionally with one or more active substances as selected from the group consisting of zinc oxide, calcium borate, manganese carbonate, magnesium carbonate, magnesium hydroxide, ammonium molybdate and hydrophobic active substances such as oil-soluble compounds of vitamins, minerals, microorganisms, plant extracts, algae, fatty acids, pharmaceutical substances, plant protection products, biocides, enzymes and cosmetic active substances , in a solution of silic iumic acid in water is emulsified into a W / O / W emulsion, a so-called W / O / W Si emulsion.
    The emulsion or co-emulsion according to the invention preferably contains an aqueous solution of silicic acid, the silicon concentration of at least 0.001% by weight, preferably between 0.001 and 10,000% by weight, more preferably between 0.01 and 5.000% by weight, and is preferably between 0.1 and 3,000% by weight. The aqueous silicic acid solution in the emulsion or co-emulsion according to the invention preferably contains a volume concentration of stabilizing substances of 1 - 95%, preferably 10 - 70%, more preferably 20 - 60%.
    A further aspect of the present invention provides a method for preparing a W / O emulsion or O / W emulsion according to the invention, wherein: one or more active substances as selected from the group consisting of zinc oxide, calcium borate, manganese carbonate, magnesium carbonate, magnesium hydroxide and ammonium molybdate and hydrophobic active substances such as oil-soluble compounds of vitamins, minerals, microorganisms, plant extracts, algae, fatty acids, pharmaceutical substances, plant protection products, biocides, enzymes, cosmetic active substances and surfactants which stabilize the oil active substances such as nonionic block copolymers, polyester / polyamine condensation polymers and polymeric dispersants, are added to oil to form the oil phase; silicic acid is produced in water by means of an acid-base reaction of a silicon compound with a strong acid or by hydrolysis of silicon compounds in the form of salts such as halides, for example silicon tetrachloride, esters, rocks such as quartz or flint or acyl group derivatives such as silicon tetraacetate, after which the produced silicic acid is preferably purified by means of ion exchange and surfactants and stabilizing substances thus formed are added to a volume concentration of stabilizing substances of 1 - 95%, preferably 10 - 70%, more preferably preferably 20 - 60% - for a W / O emulsion one or more W / O block copolymers are added to the oil phase and the water phase in the oil phase is emulsified and for an O / W emulsion one or more O / W block copolymers are added to the aqueous phase and the oil phase is emulsified in the aqueous phase and - optionally surface act Active substances, additives, binders, thickeners, antifoams, fragrances, colorants and / or flavorings are added to the W / O or O / W forming emulsion.
    Furthermore, the present invention provides a method for preparing a
    Wsi / O / W emulsion according to the invention, wherein the W / O emulsion formed according to the method described above is emulsified in water without silicic acid optionally with one or more active substances as selected from the group consisting of water-soluble salts of potassium, calcium , magnesium, iron, copper, manganese, molybdenum and boron and hydrophilic / lipophilic active substances such as water-soluble compounds of vitamins, minerals, microorganisms, plant extracts, algae, fatty acids, pharmaceuticals, plant protection products, biocides, enzymes, cosmetic active substances and optionally surfactants, additives, binders, thickeners, antifoams, fragrances, colorants and / or flavorings are added to the Wsi / O / W forming emulsion.
    The invention also provides a method for preparing an O / W / O emulsion according to the invention wherein the O / W emulsion formed according to the method described above is emulsified in oil optionally with one or more active substances selected from the group consisting of zinc oxide , calcium borate, manganese carbonate, magnesium carbonate, magnesium hydroxide and ammonium molybdate, and optionally adding surfactants, additives, binders, thickeners, antifoams, fragrances, colorants, and / or flavorings to the O / W / O forming emulsion.
    Another aspect of the invention offers the use of one or more of the emulsions according to the invention as a medical or cosmetic agent, food supplement, liquid fertilizer, crop protection agent, biocide, biostimulant, plant nutrient, soil conditioner, catalyst, antioxidant or household product such as a dermatological product or perfume.
    The emulsions and co-emulsions according to the invention optionally also contain other surfactants in addition to block copolymers and further additives, binders, thickeners, fragrances, colors and / or flavors.
    In the present application, a block copolymer is understood to mean a copolymer whose polymer chains are composed of consecutive segments or "blocks" of two or more different polymers. A block copolymer consisting of a block of one polymer A coupled to a block of a second polymer B is called a diblock A-B. A triblock consists of three blocks, this can be A-B-A or B-A-B. Multiblock copolymers may consist of alternating blocks (A-B) n, (A-B-C) n, etc., but many other arrangements are possible. The polymers A, B, C ... can be both homopolymers and copolymers.
    With block copolymers, polymers can be obtained that combine the properties of the individual polymers in a specific way. For example, a surface-active polymer can be obtained if block A is hydrophobic and block B is hydrophilic. The different types of polymers, the mutual ratios and the different molecular weights per polymer ensure the different properties of the block copolymer. In this way, one block polymer is suitable for a W / O emulsion and the other for an O / W emulsion.
    In the present application, active substance is to be understood to mean all active substances except silicic acid. By active substance and also by silicic acid is meant such a compound in a bioavailable form, that is to say in a form which is active in any way in or on human, animal, plant, aquatic organism, insect or microorganism. Furthermore, in this patent application by "emulsified in ... to an ... emulsion" is meant the emulsion formed itself. In this application, silicic acid is understood to be monomeric silicic acid or Si (OH) 4, also called ortho silicic acid, mono silicic acid, silicon tetrahydroxide and tetrahydroxysilane, this molecule can be identified by the beta silica molybdate method as described in The Chemistry of Silica on page 97. The concepts of multiple and co-emulsion are both used for emulsion in an extra liquid phase, whereby the umbrella concept of emulsion, if applicable, also includes multiple or co-emulsion. Subsequently, a summary of "selected from one or more of connections and a group of connections" means any possible combination, that is, one or more of each separate connection optionally with one or more members of the group and vice versa. In the designation of a co-emulsion with two water phases, the designation si denotes the aqueous phase with silicon acid dissolved therein. It will be clear that in the emulsions according to the invention always silicic acid is present in the aqueous phase.
    In an article by K.A. Allen and WJ McDowell, see http://web.oml.gov/info/reports/1959/3445603613999.pdf, Emulsion stabilization by silicic acid, ORNL-2771, Chemical Technology Division (1959) is a water in oil (W / O) emulsion with silicic acid in oil with a secondary amine. Here, silicic acid is used for stabilization, but is not itself stabilized. Furthermore, the silicic acid in this emulsion will form a gel that is not absorbable by an organism and therefore not bioavailable.
    The emulsion according to the invention offers a satisfactory solution to a long-standing problem: providing a stable solution of silicic acid, a compound with important active properties, optionally together with other active substances. The invention is based on mixtures of single and multiple emulsions or co-emulsions, wherein the different drops of the different phases contain silicic acid on the one hand and other active substances on the other. In this way, each active ingredient retains its own identity. Active substances other than silicic acid but which also undergo a negative interaction with each other can be separated from one another in multiple emulsions in the different drops. In an O / W emulsion according to the invention, the oil optionally with active substance dissolved therein is in drops in the aqueous phase with silicic acid dissolved therein. In a W / O emulsion according to the invention, the aqueous phase with silicic acid dissolved in droplets is optionally in the oil phase with active substance dissolved therein. In the case of co-emulsions, different active substances may be present in the two water or oil phases, with silica being always dissolved in at least one aqueous phase.
    For product registrations of, for example, food supplements and liquid fertilizers, and certainly for applications in the medical sector, it is very important to know exactly what the identity of each active substance is. In many cases, aqueous solutions of silicic acid in combination with other active substances enter into highly complex compounds, of which it is not possible to determine what the silicon compound looks like with commonly used detection methods, but which cannot be prevented under the influence of Ca, Mg, B, P, Al, Mo, Fe and Ur ions the Si (OH) 4 structure (partially or in its entirety, depending on concentrations) is lost and 'converts' into a complex compound. Product registrations in this way create inaccuracies in files, which may lead to scenarios that are in conflict with legislation. Authorities must be exactly aware of the identity of substances to which, for example, the population, animals, aquatic organisms and nature are exposed. The stable silicon emulsions according to the invention also offer a solution for this problem.
    In particular for the use of one or more of the emulsions as a medical or cosmetic agent, as a food supplement or as a liquid fertilizer, the various emulsions and co-emulsions according to the invention must contain highly pure silicic acid. The purification of silicic acid from heavy metals, such as aluminum, can be done by means of separation techniques such as filtration, reverse osmosis and ion exchange.
    The invention is explained on the basis of an example.
    Preparation W / O emulsion of silicic acid
    Step 1. Preparation of 100% monomeric silicic acid solution “liquid A”:
    Fill tank # 1 with 15.00 kg of H2O and slowly add 5.00 kg of Polyethylene glycol 400 and mix it for 30 minutes. Then add 2.50 kg of HC137% with stirring. Fill tank # 2 with 22.50 kg of H2O and 10.00 kg of K2S1O3, and mix for 60 minutes. Add this drop by drop to tank # 1 with stirring.
    Then slowly add 40.00 kg of Polyethylene glycol 400 to tank # 1 with stirring and lower the pH to <1 by adding dropwise 5.00 kg of HCl 37%. Mixing takes place at room temperature.
    The liquid is a stable colorless and transparent solution and has a silicon content of 1.2%. 100% silicic acid as monomers is measured (a complete reaction within two minutes) with the "beta silica molybdate" method according to the description of page 97 in The Chemistry of Silica (1979). This product is called liquid A.
    Step 2. Preparation W / O emulsion:
    1000 ml vegetable oil and 1000 ml liquid A are poured into a 2500 ml measuring cup. To this is added 100 ml non-ionic block polymer with a hydrophilic-lipophilic (HLB) value of 6 and the whole is added under high speed for 2-10 minutes mixed with an ultrasonic mixer. The remaining emulsion is milky and stable for at least a week. This emulsion can be administered directly, for example, by spraying as a synergistic product for the efficacy of active substances intended for the development or protection of crops.
    Although the invention has been explained above with reference to a number of single and multiple emulsions and an example, it is to be understood that the invention is by no means limited thereto. On the contrary, many variations are possible for a person skilled in the art within the scope of the invention.
    权利要求:
    Claims (22)
    [1]
    An emulsion of water and oil containing a solution of silicic acid and one or more stabilizing compounds in water, and one or more block copolymers as an emulsifier.
    [2]
    Emulsion according to claim 1 containing one or more active substances.
    [3]
    Emulsion according to claim 1 or 2, wherein the pH of the solution of silicic acid is 0 - 12.
    [4]
    Emulsion according to one or more of the preceding claims, in which the one or more stabilizing compounds have electrostatic or steric properties.
    [5]
    The emulsion according to claim 4, wherein the stabilizing compounds with electrostatic properties are polar compounds such as quaternary ammonium salts.
    [6]
    The emulsion of claim 4 wherein the stabilizing compounds with steric properties are hydrogen adsorbing agents such as one or more selected from the group consisting of polysorbate, vegetable gum, cellulose, polyglycerol esters, polyethylene glycol, dextrose, propylene glycol, pectin and sugars.
    [7]
    Emulsion according to one or more of the preceding claims, in which the aqueous solution of silicic acid is emulsified in the oil with one or more W / O block copolymers to form a W / O emulsion.
    [8]
    Emulsion according to one or more of the preceding claims, in which the oil is emulsified in the aqueous solution of silicic acid with one or more O / W block copolymers to form an O / W emulsion.
    [9]
    An emulsion in which the W / O emulsion according to claim 7 is emulsified in water without silicic acid to form a Wsi / O / W emulsion.
    [10]
    The emulsion according to claim 9, wherein the water without silicic acid in the Wsi / O / W emulsion contains one or more water-soluble active substances.
    [11]
    The emulsion of claim 10 wherein the one or more water-soluble active substances are selected from the group consisting of water-soluble salts of potassium, calcium, magnesium, iron, copper, manganese, molybdenum, boron and hydrophilic / lipophilic active substances.
    [12]
    An emulsion in which the O / W emulsion according to claim 8 is emulsified in oil to form an O / W / O emulsion with two oil phases.
    [13]
    Emulsion according to one or more of the preceding claims, in which the oil or optionally both oil phases contains one or more oil-soluble active substances.
    [14]
    The emulsion of claim 13 wherein the one or more oil-soluble active substances are selected from the group consisting of zinc oxide, calcium borate, manganese carbonate, magnesium carbonate, magnesium hydroxide, ammonium molybdate and hydrophobic active substances.
    [15]
    Emulsion according to one or more of the preceding claims, wherein one or each of the two oil phases are selected from the group consisting of vegetable, animal, essential and essential oils.
    [16]
    An emulsion according to claims 1-6 wherein an emulsion of a solution of water optionally with one or more active substances as selected from the group consisting of water-soluble salts of potassium, calcium, magnesium, iron, copper, manganese, molybdenum, boron and hydrophilic / lipophilic active substances, optionally in oil with one or more oil-soluble active substances as selected from the group consisting of zinc oxide, calcium borate, manganese carbonate, magnesium carbonate, magnesium hydroxide, ammonium molybdate and hydrophobic active substances emulsified in a solution of silicic acid in water is up to a W / O / Wsi emulsion.
    [17]
    17. An emulsion according to any one of the preceding claims, wherein the aqueous solution of silicic acid contains a concentration of silicon of at least 0.001% by weight.
    [18]
    Emulsion according to one or more of the preceding claims, in which the aqueous solution of silicic acid contains a volume concentration of stabilizing substances of 1 - 95%.
    [19]
    A method for preparing a W / O emulsion according to claim 7 or O / W emulsion according to claim 8 wherein: one or more active substances selected from the group consisting of zinc oxide, calcium borate, manganese carbonate, magnesium carbonate, magnesium hydroxide, ammonium molybdate, hydrophobic active substances and surfactants that keep the oil-active substances stable are added to oil to form the oil phase; silicic acid is produced in water by means of an acid-base reaction of a silicon compound with a strong acid or by hydrolysis of silicon compounds in the form of salts and surface active substances and stabilizing substances are added to the thus formed aqueous phase surfactants to a volume concentration of stabilizing substances of 1 - 95%, preferably 10 - 70%, more preferably 20 - 60%, after which the silicic acid produced is preferably purified by means of ion exchange and for a W / O emulsion one or more W / O blocking co-polymers are added to the oil phase and the aqueous phase is emulsified in the oil phase, and for an O / W emulsion one or more O / W block copolymers are added to the aqueous phase and the oil phase is emulsified in the aqueous phase; and wherein optionally surfactants, additives, binders, thickeners, antifoams, fragrances, colorants and / or flavorings are added to the W / O or O / W forming emulsion.
    [20]
    A method of preparing a Wsi / O / W emulsion according to any of claims 9-11 wherein the W / O emulsion formed according to the method of claim 19 is emulsified in water without silicic acid optionally with one or more active substances as selected from the group consisting of water-soluble salts of potassium, calcium, magnesium, iron, copper, manganese, molybdenum, boron, and hydrophilic / lipophilic active substances and where optional surfactants, additives, binders, thickeners, antifoams, fragrances, colorants and / or flavorings are added to the Wsi / O / W forming emulsion.
    [21]
    A method for preparing an O / W / O emulsion according to any one of claims 12 to 14 wherein the O / W emulsion formed according to the method of claim 19 is emulsified in oil optionally with one or more active substances as selected from the group consisting of zinc oxide, calcium borate, manganese carbonate, magnesium carbonate, magnesium hydroxide and ammonium molybdate, and optionally adding surfactants, additives, binders, thickeners, antifoams, fragrances, colorants and / or flavorings to the O / W / O forming emulsion.
    [22]
    Use of one or more of the emulsions according to claims 1 to 18 as a medical or cosmetic agent, food supplement, liquid fertilizer, crop protection agent, biocide, biostimulant, plant nutrient, soil conditioner, catalyst, antioxidant or household product.
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    同族专利:
    公开号 | 公开日
    US10611698B2|2020-04-07|
    US20170066694A1|2017-03-09|
    EP3141244A1|2017-03-15|
    NL2017436B1|2017-09-20|
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    法律状态:
    2018-10-03| PD| Change of ownership|Owner name: CINDRO HOLDING BV; NL Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), ASSIGNMENT; FORMER OWNER NAME: BIO SCIENCE B.V. Effective date: 20180802 |
    优先权:
    申请号 | 申请日 | 专利标题
    NL1041500|2015-09-09|
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