• 专利附录
  • 专利说明
  • 权利要求
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    • 专利摘要:
    Sulfur-Containing Compounds A composition that adsorbs and removes or reduces odors associated with the ingestion of food or drugs that cause sulfur odors, such as garlic or onions, contains metal complexes of substrates and ligands. The complex may be contained in a carrier such as silica gel and has low solubility in an aqueous environment. The ligands of the composition may contain amino acids containing sulfur, nitrogen or carboxylic acids, such as cystine, and the substrate is a metal which may be copper, zinc or iron.
    公开号:KR20020068498A
    申请号:KR1020027001953
    申请日:2000-08-14
    公开日:2002-08-27
    发明作者:베르그케네쓰에이
    申请人:피큐 홀딩, 인코포레이티드；
    IPC主号:
    专利说明:

    Sulfur sorbent for reducing onion and garlic odors {SULFUR ADSORBENT FOR REDUCING ONION OR GARLIC BREATH ODOR}
    [2] Many chemicals and foods contain sulfur containing compounds that have a strong odor. Ingestion of chemicals and foods causes breath with an unpleasant odor due to the ingested compounds or their metabolites, or both. Garlic and onions are particularly foods with a strong sulfur odor, causing particularly unpleasant odors.
    [3] Garlic and other food products and chemicals contain or produce various sulfur containing ingredients, including allicin, allin, and diaryl disulfide. Sulfur-containing compounds found to be due to ingestion of garlic or other food products include allyl mercaptan, diallyl disulfide, dimethyl disulfide, dipropyl disulfide, methyl allyl disulfide, allyl methyl sulfide, diallyl sulfide, dimethyl Trisulfide, methyl allyl trisulfide, and allyl thiols.
    [4] Removal of sulfur odors, including odors from foods such as garlic and onions, and drugs has been attempted using various chemical compounds and processes. Many of these attempts have involved removing odors from an individual's breath.
    [5] Both chlorophyll and lemon juice have been reported to eliminate the odor associated with garlic intake. In addition, a combination of ginger seeds, menthol, coriander, essential oils, and chlorophyll was used to prevent bad breath. Green tea flavonoids and cyclodextrins have both been used to refresh breath. In addition, cyclodextrins have been used to deodorize garlic extracts. Corinoids have also been used to prevent sulfur odors in certain pharmaceuticals.
    [6] Attempts to obtain odorless garlic include ethanol and alpha enzymes; Dried egg yolk and eggshell; Myo-inositol hexaphosphate esters, egg powder or both; Magnesium hydroxide; Suspensions of calcium (and / or magnesium) salts, alginates, zeolites and diatomaceous earth; Sodium bicarbonate, and mixtures of organic acids; Alpha and beta unsaturated organic acids; Sliced pork and powdered carrot leaves; Silica gel, phytic acid and zinc salts; Carbonate and acetic acid; Solutions of sweet sake, vinegar, citric acid and egg white; Vitamin C and various dry plant parts; Treatment with magnesium oxide powder: drying by heating in a carbon dioxide atmosphere. A common problem with many of these compositions and methods is that they alter the flavor of a food or orally taken drug when they are incorporated into a food or drug.
    [7] In addition, sulfur adsorbents have generally been used to remove sulfur dioxide and derivatives thereof, instead of reduced sulfur such as hydrogenated sulfides, mercaptans and allyl sulfides commonly found in garlic. In general, compounds previously used include carbon and copper, copper oxide, copper carbonate on cellulose, clinoptilolite, and copper supported on aluminum silicate. They are not incorporated into foods.
    [8] Thus, there remains a need for compositions and methods that can adsorb sulfur containing compounds, remove or reduce sulfur odors such as those found in garlic and onions, and derivatives and metabolites thereof, and can be incorporated into food and orally ingested drugs. It is becoming. In order to overcome the disadvantages of existing adsorbents and treatments for removing sulfur-based odors, novel sulfur adsorbent compositions and methods are provided that remove or reduce the sulfur odor in the breath.
    [9] Summary of the Invention
    [10] In order to achieve the above and other objects, the present invention provides a composition that adsorbs sulfur-containing compounds to remove or reduce the bad breath caused by garlic, onions, and other foods or drugs. These compositions may be provided in various forms such as gum, spray, mint or mouthwash, and do not interfere with the flavor of the product. These compositions are low solubility metal complexes in aqueous environments and contain a substrate and a ligand, and optionally a support. The ligand may contain amino acids whose side chains contain sulfur, nitrogen or carboxylic acids; The substrate may contain a metal complexed with a ligand. Optionally, the complex is contained in a carrier. In addition, a strong cation exchanger based on polystyrene as the sulfur compound adsorbent is complexed to the metal ion functional group.
    [11] In a further embodiment of the invention, the complex contains naturally occurring amino acids, naturally occurring modified amino acids, or non-naturally occurring amino acids, each of which side chains are sulfur, nitrogen, or carboxylic acid and Contains complexed metals. The complex is substantially insoluble in water or in other aqueous environments and is distributed throughout the silica gel. Gel carriers in which the complex is distributed throughout are less soluble in an aqueous environment than the complex itself.
    [12] In another embodiment of the present invention, a method is provided for removing or reducing sulfur odors associated with consumption of foods or drugs such as garlic and onions. Such methods include orally administering the adsorbent composition of the present invention to an individual who has eaten a food or drug that produces a sulfur odor.
    [13] It is to be understood that both the foregoing general description and the following detailed description are exemplary and are not limitative of the invention.
    [1] The present invention generally relates to compositions and methods for eliminating or reducing bad breath caused by sulfur-containing compounds produced upon ingestion of foods and drugs. More specifically, the present invention relates to eliminating or reducing bad breath by adsorbing sulfur-containing compounds and their components and derivatives contained in food containing garlic or onions.
    [14] The sulfur adsorbent composition of the present invention contains a complex of two components, a substrate and a ligand. Ligands are generally amino acids and substrates are metals complexed with ligands. The components of the adsorbent composition are preferably low in solubility in water and contained in the carrier. Low solubility complexes allow the adsorbent to be present longer at adsorption sites such as the oral cavity.
    [15] Amino acids include sulfur in their side chains such as cysteine or methionine; Nitrogen containing in the side chain thereof, such as tryptophan, asparagine, glutamine, lysine, arginine or histidine; Or it may be one containing carboxylic acid in its side chain, such as aspartic acid or glutamic acid. Both naturally occurring and modified forms of amino acids can be used in the complexes. In addition, non-naturally occurring amino acids containing sulfur, nitrogen or carboxylic acid in the side chain may be included in the complex. By way of example, non-naturally occurring amino acids similar to cysteine, in which the methyl group of the CH 2 -SH side chain is substituted with a similar alkyl group such as ethyl or propyl group can be used.
    [16] Modified forms of amino acids are conceivable of minor changes in amino acids that do not cause any substantial change in functionality. Oxidation is a type of possible modification in naturally occurring amino acids. Cysteine can be modified by oxidation to produce diamino acid cysteine.
    [17] The complexing agent is a metal, preferably copper, zinc, iron or any other suitable complexing metal. The carrier may be a gel such as silica gel or other suitable carrier material. Preferred adsorbents contain a complex of cystine (or cystine HCl) and copper in silica gel.
    [18] The complex is poorly soluble in water or in other aqueous environments. For example, upon contact with saliva, the complex remains a substantially insoluble solid for at least one hour in the oral cavity of a human under typical conditions.
    [19] The composition is effective to eliminate or reduce bad breath caused by sulfur containing compounds. Examples of such odors are odors caused by garlic's substituents or metabolites. These may be composed of allyl sulfides such as allicin and allin.
    [20] The composition may be in powder form, which may be incorporated into chewing gum, mint or other product, or in solid or liquid form, such as a mouthwash or spray. The composition does not affect the flavor of the gum or other product to be incorporated. Specifically, the sulfur adsorbent composition of the present invention does not affect the fragrance of mint oil, which is often present in chewing gum, mint formulations or mouthwashes.
    [21] Metal complexes with substances other than amino acids may also be effective sulfur odor-reducing compositions. Like sulfonic acids, compounds having strong cation exchange groups as functional groups can be complexed with metal ions to produce complexes effective for removing odors from sulfur containing compounds. The expression "strong cation exchanger" as used herein has a conventional meaning, i.e., a compound in which a reversible chemical reaction occurs easily in which cations are interchanged between the compound and other compounds. One type of strong cation exchanger is a strong cation exchanger based on polystyrene which is produced from monomer (C 6 H 5 CHCH 2 ) n and preferably has a SO 3 − group at the 3 ′ position. For example, Dowex®, a strong cation exchanger resin based on polystyrene . 50W (Dow Chemical Company) is an effective sulfur adsorbent when complexed with metal ions.
    [22] The compositions of the present invention are administered by oral placement of gums, mints, sprays, mouthwashes or other vehicles for delivering the compositions. Preferably, the composition remains in the oral cavity for a period of time up to about one hour, sufficient to remove or reduce sulfur related odors.
    [23] The adsorbent concentration in gum, mint, mouthwash or spray can vary widely and depends on many factors that vary with each situation. These factors include the type of complex, the odor being reduced, the form of the food, and the duration of the desired effect. In one example, cystine-copper is added to the gum at a concentration of 0.3% by weight. In addition, when a carrier is used, the concentration of the metal complex in the carrier may also vary widely. The concentration should not be high enough to adversely affect the gelation of the carrier, but should not be low enough to be ineffective. A concentration of 20% by weight in the carrier was found to be suitable.
    [24] Reference may be made here to adsorption and adsorbents, but this should not be understood as excluding other mechanisms that occur in reducing odors. Adsorption is the primary mechanism for reducing odor, but other mechanisms such as absorption are also believed to occur.
    [25] Example 1: Synthesis of Cystine-Copper Complex
    [26] 40 ml of water were combined with 4.42 g of cystine HCl and its pH was set to 10 with 1M NaOH to prepare a cystine solution. A drop of 1 M copper sulfate was added and at room temperature, oxygen was bubbled through the solution until the purple solution turned green. The pH was adjusted to 6-8 using hydrochloric acid.
    [27] A solution of the metal salt was prepared by combining 4.32 g of copper chloride dihydrate with 10 ml of water. Slow combinations of the metal and amino acid solutions with stirring gave an insoluble complex immediately. The pH was adjusted to 6-8 using 1M sodium hydroxide. The complexes were washed with water and removed by filtration with a Buechner funnel. The complex was dried overnight in a 60 ° C. oven.
    [28] Example 2: Synthesis of Silica-Supported Cystine-Copper Complex
    [29] An aqueous suspension of the cystine-copper complex of Example 1 (5 g in 50 ml) was diluted with sodium silicate (200 ml of sodium silicate (SiO 2 : Na 2 O ratio of 3:22 w / w, 37.6% solids) + 200 mL water), to which about 20 mL of 8 N sulfuric acid was quickly added and mixed. The suspension gelled in 3 minutes. After incubation at room temperature for 60 minutes, the solids were broken, washed with water having a conductivity of 650 μSimens, dried at 60 ° C. and then ground to a powder.
    [30] Example 3: Synthesis of Cation Exchanger-Copper Complexes Based on Polystyrene
    [31] Dowex An aliquot (2.0 g) of 50 W (H + type, 200-400 mesh) was stirred with 50 ml of 0.1 M copper chloride at room temperature for 2 minutes. The pH was adjusted to neutral with 10 N and 1 N sodium hydroxide and stirring continued for 10 minutes. The green solid was then filtered off, washed three times with 500 ml of water and then dried at 60 ° C. overnight.
    [32] Example 4: Activity of Cystine-Copper Complex
    [33] All dilution operations were performed with water under nitrogen in the capped bottle. Hydrogen emulsion was measured as a gas in a syringe and injected into a sealed bottle containing deoxygenated water. After shaking, it was assumed that all hydrogen sulfide (H 2 S) was dissolved in water, and the concentration (ppb w / w) was calculated using the density of the gas.
    [34] All liquid compounds were treated with a syringe. Thiol concentrations were recorded assuming that their specific gravity was 1. Prior to sealing and prior to addition of the dilute sulfide solution at room temperature, an adsorbent as prepared in Example 1 was weighed into the bottle as a dry powder. After shaking for 20 minutes, the bottle was opened and carefully smelled the contents.
    [35] Table 1 shows the adsorption of sulfur compounds even in the presence of mint oil. The purpose of this experiment was to remove the thiol odor, not the mint oil aroma. The adsorbent not only removed the smell of all three sulfur compounds, but also did not reduce the fragrance of the mint oil at all.
    [36] Sulfur compound adsorption in the presence of mint oil. All sulfur compounds were present in 5 ppb (w / v) except hydrogen sulfide (50 ppb). Mint oil was added at the 50 ppb level. The adsorbent was 0.1% w / v. Sulfur compoundsH 2 SDiallyl disulfidePropane thiolAllyl mercaptan smellgarlicMintgarlicMintgarlicMintgarlicMint effectnoneStrongVery weakModerateFaintModerateVery faintModerate
    [37] Example 5: Activity of Other Metal-Amino Acid Complexes
    [38] Each amino acid solution was prepared by dissolving 2.74 g of amino acid in 40 ml water. A complex with a metal was synthesized according to the description in the second step of Example 1.
    [39] Allyl mercaptan in water was tested for 5 ml solution odor removal containing 627 nmol. The suspension of the metal complex was mixed with the mercaptan solution and reacted in a sealed vial at room temperature for 10 minutes before taking off the residual odor.
    [40] Table 2 shows that in addition to the copper complexes, the ferric ion and zinc complexes have some activity in removing allyl mercaptans.
    [41] Activation of metal complexes for eliminating garlic odors. (Symbol: ++ = complete odor removal; + = slight odor remaining;-= no odor removal; NA = complex was insoluble; = Allyl mercaptan odor masked by methionine odor) metalamino acid MethionineAsparagineCysteineCystineGlycineAspartic acidIon Exchange Resin (Dowex 50) Cu ++++++-+++ Fe III +++-++ Zn +++-++ Mg------- Mn--NANA--+
    [42] As indicated above and shown in Table 2, metal complexes with substances other than amino acids are effective. Compounds having strong cation exchange groups as functional groups, such as sulfonic acids, can be complexed to metal ions to produce complexes effective for removing odors from sulfur containing compounds. By way of example, in a strong cation exchange resin based on polystyrene Dowex 50 (particle size 38-75 μm, obtained from Dow Chemical Company) is an effective sulfur adsorbent when complexed with metal ions.
    [43] Although described and described herein with reference to certain specific embodiments, it is not intended to be limited to the details shown herein. Various modifications may be made in the details within the scope and range equivalent to the claims without departing from the spirit of the invention.
    权利要求:
    Claims (17)
    [1" claim-type="Currently amended] A composition for adsorbing a sulfur-containing compound containing a metal complex of a ligand and a substrate, wherein the complex has low solubility in an aqueous environment.
    [2" claim-type="Currently amended] The composition of claim 1 wherein the substrate is a metal selected from the group consisting of copper, zinc and iron.
    [3" claim-type="Currently amended] 2. A compound according to claim 1 wherein the ligand is a naturally occurring amino acid containing sulfur, nitrogen or carboxylic acid; Naturally occurring modified amino acids containing sulfur, nitrogen or carboxylic acids; And a non-naturally occurring amino acid containing sulfur, nitrogen or carboxylic acid.
    [4" claim-type="Currently amended] 4. The composition of claim 3 wherein the amino acid is selected from the group consisting of cystine, cysteine, methionine, tryptophan, asparagine, glutamine, lysine, arginine and histidine.
    [5" claim-type="Currently amended] The composition of claim 4 wherein the amino acid is cystine and the metal is copper.
    [6" claim-type="Currently amended] 6. The composition of claim 5, wherein the amino acid is cystine HCl.
    [7" claim-type="Currently amended] The composition of claim 1, further comprising a carrier.
    [8" claim-type="Currently amended] 8. The composition of claim 7, wherein the carrier is silica gel.
    [9" claim-type="Currently amended] The composition of claim 8 wherein the ligand is cystine and the substrate is copper.
    [10" claim-type="Currently amended] 10. The composition of claim 9, wherein the amino acid is cystine HCl.
    [11" claim-type="Currently amended] The composition of claim 8 wherein the ligand is a strong cation exchange group and the substrate is a metal.
    [12" claim-type="Currently amended] 12. The composition of claim 11 wherein the strong cation exchange group is based on polystyrene having sulfonic acid functionality and the metal is copper.
    [13" claim-type="Currently amended] A composition for adsorption of sulfur containing a complex of cystine HCl and copper in silica gel.
    [14" claim-type="Currently amended] The composition of claim 1 contained in a gum, mint, mouthwash or spray.
    [15" claim-type="Currently amended] The composition of claim 13 contained in a gum, mint, mouthwash or spray.
    [16" claim-type="Currently amended] A method for removing or reducing bad breath caused by sulfur containing compounds, comprising administering to the individual a composition according to claim 12.
    [17" claim-type="Currently amended] A method for eliminating or reducing bad breath caused by sulfur containing compounds, comprising administering to the individual a composition according to claim 13.
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    同族专利:
    公开号 | 公开日
    DE60016235T2|2005-12-22|
    CN1368873A|2002-09-11|
    CN1148164C|2004-05-05|
    WO2001012136A2|2001-02-22|
    JP3595797B2|2004-12-02|
    EP1204402B1|2004-11-24|
    ES2231238T3|2005-05-16|
    AU6775300A|2001-03-13|
    JP2003506469A|2003-02-18|
    AT283029T|2004-12-15|
    CA2380680C|2005-12-27|
    AU762783B2|2003-07-03|
    DE60016235D1|2004-12-30|
    WO2001012136A3|2001-09-13|
    CA2380680A1|2001-02-22|
    EP1204402A2|2002-05-15|
    US6403642B1|2002-06-11|
    KR100488609B1|2005-05-11|
    MXPA02001414A|2002-07-30|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    法律状态:
    1999-08-16|Priority to US14903199P
    1999-08-16|Priority to US60/149,031
    2000-08-14|Application filed by 피큐 홀딩, 인코포레이티드
    2002-08-27|Publication of KR20020068498A
    2005-05-11|Application granted
    2005-05-11|Publication of KR100488609B1
    优先权:
    申请号 | 申请日 | 专利标题
    US14903199P| true| 1999-08-16|1999-08-16|
    US60/149,031|1999-08-16|
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