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    • 专利摘要:
    The present invention relates to an antistress composition that includes various medicinal plants as an active ingredient to relieve stress and to suppress memory loss. Specifically, the present invention relates to malt ( fr , fructus hordel germintus ), new song, 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of messa medicata fermentata ), sine ( 砂仁 , fructus amomi ), and sansa (mountain company, fructus crataegei ), radix polygalae ( 원 志 ), sanjoin (酸棗仁, consisting of semen zizyphi spinosae) and seokchangpo (石菖浦, graminei rhizoma acori) 2.0 40.0 ~ g one or more herbs selected from the group consisting of, baekboksin (白茯神, poria holen) and baekbokryeong (百茯笭coming, poria) 2.0-40.0 g of one or more medicinal herbs selected from the group, bamboo leaves (竹葉, folium phyllostachyos ), kill (竹茹, calus in taein phyllostachyos ), bamboo shoots (竹瀝, succus phyllostachyos ) and golden (黄 芩, radix scu one or more medicinal herbs selected from the group consisting of tellariae ) 2.0-40.0 g, rhubarb wang (大 um 黃 卷, leguminosae ), baekdu ( fructus amomi cardamomi ), black soybean (black semen , semen glycine ) and white migraine ( 2.0-40.0 g of at least one medicinal herb selected from the group consisting of 白 篇 豆, semen lablab ), ginger (生 rhi, rhizoma zingiberis ), sexin (細辛, radix asari ), health (乾薑, rhizoma zingiberis siccatum ) and 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of the rich ( radix aconiti ), ginseng ( bulusus allii fistulosi ), ephedra ( herba ephedrae ) and lobule ( folium perillae ) A mixture consisting of 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of red pepper and radix platycodi as an active ingredient Contains antistress agent It relates to the sacred. Since the antistress agent composition of the present invention has an excellent effect of relieving stress and suppressing memory loss due to excessive stress, it may be usefully used as a preventive and therapeutic agent for stress as well as being applied to health food.
    公开号:KR20020022342A
    申请号:KR1020000055082
    申请日:2000-09-20
    公开日:2002-03-27
    发明作者:최병학；박경미
    申请人:최병학；
    IPC主号:
    专利说明:

    An antistress composition for a stress prevention and treatment
    [8] The present invention relates to an antistress composition that includes various medicinal plants as an active ingredient to relieve stress and to suppress memory loss. Specifically, the present invention relates to malt ( fr , fructus hordel germintus ), new song, 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of messa medicata fermentata ), sine ( 砂仁 , fructus amomi ), and sansa (mountain company, fructus crataegei ), radix polygalae ( 원 志 ), sanjoin (酸棗仁, consisting of semen zizyphi spinosae) and seokchangpo (石菖浦, graminei rhizoma acori) 2.0 40.0 ~ g one or more herbs selected from the group consisting of, baekboksin (白茯神, poria holen) and baekbokryeong (百茯笭coming, poria) 2.0-40.0 g of one or more medicinal herbs selected from the group, bamboo leaves (竹葉, folium phyllostachyos ), kill (竹茹, calus in taein phyllostachyos ), bamboo shoots (竹瀝, succus phyllostachyos ) and golden (黄 芩, radix scu one or more medicinal herbs selected from the group consisting of tellariae ) 2.0-40.0 g, rhubarb wang (大 um 黃 卷, leguminosae ), baekdu ( fructus amomi cardamomi ), black soybean (black semen , semen glycine ) and white migraine ( 2.0-40.0 g of at least one medicinal herb selected from the group consisting of 白 篇 豆, semen lablab ), ginger (生 rhi, rhizoma zingiberis ), sexin (細辛, radix asari ), health (乾薑, rhizoma zingiberis siccatum ) and 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of the rich ( radix aconiti ), ginseng ( bulusus allii fistulosi ), ephedra ( herba ephedrae ) and lobule ( folium perillae ) A mixture consisting of 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of red pepper and radix platycodi as an active ingredient Contains antistress agent It relates to a composition.
    [9] In general, when the stimulus on the living body is above a certain degree, it is injured. The living body shows a general adaptative syndrome which is non-specific in response to a certain threat regardless of the type of the stimulus. It was defined as stress (Selye, H .: The stress of life , Toronto, Longnans Green and Co., pp. 1-50, 1958).
    [10] These reactions appear in various phenomena in the body, such as tension headache, migraine, high blood pressure, indigestion, fatigue, pain, menopausal disorders, hair growth, roughness of the skin, and when chronically persisted, they cause various neurosis and stomach ulcers. As the body's physiological and immune activity is lowered and the body's homeostasis is broken, the body's resistance is weakened and other diseases are caused, which can pose a significant threat to health, reduce mental activity, and unstable emotions, resulting in abnormal behavior. It may cause. In particular, because stress is excessively occurring in modern society, stress is a very important social problem.
    [11] The stress, which is said to be the cause of modern disease, is caused by a variety of causes.
    [12] (1) Physical factors-overwork, lack of sleep, trauma, addiction, etc.
    [13] (2) External factors-natural environment, cultural situation, human relations at home or at work
    [14] (3) internal factors-personality, psychological conflict in reality, mental wounds in childhood, etc.
    [15] The effects of such stress on the human body are varied, causing symptoms such as nervousness, headache, and blood pressure rise. If the stress persists, the body's function decreases and develops into another secondary disease. The causes of stress vary as described above depending on the method applied to the living body, but in general, it is known that all reactions are mediated by promoting the secretion of the pituitary-adrenal system (HPA), which is the sympathetic nervous system, to induce hormone secretion. . The reactions are summarized as follows. The adrenal glands stimulated by adrenal cortical stimulating hormones increase in weight, decrease in lipids, and spleens are significantly reduced in weight due to decreased immune function. On the other hand, the adrenal glands secrete other steroid hormones in the blood so that cholesterol, blood sugar, alkaline phosphatase (ALP), lactate dehydrogenase (LDH), aspartate aminotransferase: AST or GOT) and alanine aminotransferase (ALT or GPT), and in severe cases, lead to a decrease in neutral lipids. These in vivo changes are known to be intermediates of the out-of-body symptoms mentioned above. Therefore, in order to prevent or treat stress, it is desirable to restore various physiological changes in the human body caused by stress.
    [16] The stress-induced changes are very diverse, and if this condition persists, it is urgently needed to control stress because it is a source of many diseases, but only physical treatment methods such as exercise, sleep, and rest are suggested. However, the method of promoting the recovery of physiological changes caused by stress with medicines or health foods has not been sufficiently presented, and there has been a need for development of medicines having a preventive and therapeutic effect on stress.
    [17] As part of this research, antistress agents have been developed that have the effect of preventing and treating stress using choline acids (Korean Patent No. 95-6225). The antistress agent containing choline acids is widely used as a gallstone dissolving agent, and has a dipharyngeal effect, liver detoxification, hepatic blood flow improving action, fat absorption promoting action, and excretion of waste products through microbilitery. It is marketed as urusdeoxycholic acid, a gallstone dissolving agent, which is known to have an effect on improvement of function, systemic malaise due to liver dysfunction, indigestion, anorexia, physical fatigue, and it is effective in treating fatty liver. Oral administration improves liver function and decreases in liver fat mass (see Japanese Patent Application Laid-Open No. Hei 4-235918) Taurorsodeoxycholic acid, a chenodeoxycholine marketed as a gallstone dissolving agent Acid (Chenodeoxycholic acid) and dihydrocholic acid (Dehydrocholic acid) contains as an active ingredient.
    [18] However, the antistress composition using choline acids is effective in the general symptoms caused by stress, such as increase of adrenal weight by stress and prevention of spleen atrophy, inhibition of ascorbic acid content change of adrenal gland and inhibition of blood biochemical changes. It has been demonstrated that there is no mention of the effects of suppressing or restoring memory loss.
    [19] In addition, as a herbal medicine or a folk remedy, various types of medicines have been developed that contain ingredients such as ginseng, tofu, and thorny ginseng which are known to have a useful effect on stress (Korean Patent No. 96-8230). Nutrient tonic drinks are mainly commercially available, and alcoholic drinks are also commercially available, and various ingredients such as honey and vitamins are also marketed as nourishing tonic. However, Ginseng, B. g. (Brekhman, II, Pharmacological investigation of glycosides from Gingseng and Eleutherococcus, Lloydia, Vol. 32, No. 1, pp. 46-51, 1969), Ocimum sanctum Linn, Tinosporamalabarica Herbs and melatonin, such as (Sen, P., Maiti, PC and Ray, A. Mechanism of anti-stress activity of Linn, eugenol and in experimentalanimals, Indian J. Exp. Biol. , 30, 592-596, 1992) Although biomaterials have been reported to exhibit anti-stress effects, among the various changes caused by stress, only a few items have been shown to be effective or ineffective, and herbal extracts that have been used as herbal medicines in the Orient have been used simply. In this respect, a large characteristic technology was not found, and the general purpose was merely to use nourishment tonic or known efficacy.
    [20] In this situation, the development of a desirable anti-stress agent that has an inhibitory effect against a variety of symptoms caused by stress, which is a big problem in modern society is required, in particular by the appropriate combination of herbal extracts are caused by a variety of causes There is an urgent need for the development of desirable anti-stress agents that are excellent in preventing or treating stresses that exhibit various symptoms.
    [21] In order to develop an antistress agent of a new composition that has not been used conventionally in combination with excellent efficacy against stress in general, the present inventors use malt, raw paper, baekxin, bamboo leaf, soybean yellow roll, ginger, baekbaek and The present invention was completed by developing a composition comprising red pepper as an active ingredient and confirming that the composition exhibits a wide range of excellent effects in preventing and treating stress and suppressing memory loss.
    [22] In order to alleviate the stress of modern people and to suppress memory loss due to excessive stress, the present invention provides a mixture of malt, grass, baekxin, bamboo leaf, soybean yellow roll, ginger, baekbaek and red pepper among medicinal plants that have a stress preventing and treating effect. It is to provide an antistress agent composition characterized by containing as an active ingredient.
    [1] 1 is a result of observing the weight change of each group according to the administration period after administration of the liquid extract of the anti-stress agent composition of the present invention to the experimental animal.
    [2] Control group; Group not administered the liquid extract of the antistress agent composition of the present invention
    [3] Experimental group; Group to which the liquid extract of the antistress agent composition of the present invention was administered
    [4] ◆; Unstressed control
    [5] ■; Stressed control group
    [6] ▲; Unstressed experimental group
    [7] *; Stressed experimental group
    [23] In order to achieve the above object, the present invention is 2.0-40.0 g of at least one medicinal herb selected from the group consisting of malt, singok, sine and hawthorn, at least one medicinal herb 2.0-40.0 selected from the group consisting of raw paper, Sanjoin and Seokchangpo g, 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of Baeksin and Bakbok-ryeong, 2.0-40.0 g of the one or more medicinal herbs selected from the group consisting of bamboo leaf, kill, mortality and gold, soybean rhubarb, baekdugu, black soybean and white flakes 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of two, 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of ginger, sessin, health and rich, 1 selected from the group consisting of baekbaek, ephedra and lobule A mixture consisting of 2.0 to 40.0 g of at least one medicinal herb and at least 2.0 to 40.0 g of one or more medicinal herbs selected from the group consisting of red pepper and Giltyeong is effective. Providing a first composition comprising the anti-stress time.
    [24] In another aspect, the present invention provides a pharmaceutical composition having the anti-stress agent composition as an active ingredient having a stress prevention and treatment effect.
    [25] In addition, the present invention provides a health food having a stress prevention and treatment effect by containing the anti-stress agent composition as an active ingredient.
    [26] Hereinafter, the present invention will be described in detail.
    [27] The antistress agent composition of the present invention is 2.0-40.0 g of at least one medicinal herb selected from the group consisting of malt, new song, sine and hawthorn, at least one medicinal herb 2.0-40.0 g selected from the group consisting of raw paper, sanjoin and quarry 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of Baek-sin and Baek-bok-ryeong, 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of bamboo leaf, kill, killing and gold, soybean yellow flakes, Baekdu-gu, black soybean and white migraine At least one medicine selected from the group consisting of 2.0-40.0 g, at least one medicine selected from the group consisting of ginger, sessin, health and the rich at least one selected from the group consisting of 2.0-40.0 g, baekbaek, ephedra and leaflets A mixture consisting of 2.0 to 40.0 g of medicinal herbs and one or more medicinal herbs 2.0 to 40.0 g selected from the group consisting of red pepper and Giltyeong as an active ingredient Include.
    [28] Malt (麥芽, fructus hordel germintus ) is obtained from germinating barley, a year-old herb , which is a traditional Korean food called malt, but is considered an enzyme derived from nature used worldwide. Malt is a germinated shoot that gives barley adequate moisture and maintains a constant temperature, which contains a large amount of amylase. By using the action of the amylase is used to prepare Sikhye, persimmon, syrup, syrup, beer and the like. Well-made malt contains not only amylase but also protease, invertase, oxidase and phytase. Among the amylases, the malt contained in the malt is alpha-amylase and beta-amylase contains little. In addition, malt protease breaks down the protein of barley to improve the aroma and taste of the beer and bring about a foaming effect.
    [29] Malt is soaked barley in water, pulled out, put it in baskets, weave it with bundles, and often watered in the state covered with bundles, soaked shoots at 60 ℃ or lower, and collected when the length of the shoots was about 3-5 cm. Use sun-dried ingredients. Malt is effective in the treatment of acute and chronic hepatitis, promotes appetite, suppresses wheezing, and treats indigestion, vomiting and diarrhea. It is preferable that the antistress agent composition of this invention contains 2.0-40.0g of malt.
    [30] As alternative medicine of the malt, a new song, sine, hawthorn may be used.
    [31] Radix polygalae (뿌리 志, radix polygalae ) is a perennial herb that belongs to the genus. The root portion contains a large amount of saponin, and the saponin is hydrolyzed and divided into two crystals, tenuiginin A and tenuginin B. In addition, it contains polygalitol, N-acetylglycosamine, alkaloid tenuidine, fatty oil and resin. Plant saponin contained in the base stimulates the gastric mucosa and causes mild nausea, so it is reflexively increasing the secretion of the bronchus and acts to dissolve red blood cells. It has also been reported that native prostheses induce excitatory action on the uterine extraction uterus of guinea pigs, rabbits, non-pregnant dogs and pregnant dogs.
    [32] The ground is taken from the roots of the ground in spring and summer to remove the core inside, soaked in licorice soaked water for 15 to 20 minutes and then dried in the shade as a medicinal herb. The base has the effect of calming the mind, clearing the head, removing the wall and releasing congestion. It also increases wisdom, improves physical strength and vision, and enhances memory. It is preferable that the antistress agent composition of this invention contains 2.0-40.0g of base papers.
    [33] Sanjoin, Seokchangpo, etc. may be used as an alternative medicine of the base paper.
    [34] Baek-sin ( poria holen ) is the root part of the plant belonging to the fungi family, which is a white part that naturally contains pine needles in the middle of the fungal nucleus. Baeksin is sweet, sour, and has a flat nature. It is generally known to calm the mind, drain water, and treat deep borders, forgetfulness, insomnia, span, and urine. When the vaccine was injected into the intestine of an excited animal by taking caffeine or the like, the experimental animal stabilized and entered a sleepy state, but there was no sleep phenomenon.
    [35] Baekboksin is harvested in the spring or summer and used as medicine. It is preferable that the antistress agent composition of this invention contains 2.0-40.0g of vaccine.
    [36] Baekbokryeong can be used as an alternative medicine for the Baeksin.
    [37] Bamboo leaf ( folium phyllostachyos ) refers to the young leaves of cotton wool, a perennial plant belonging to the family of asteraceae, which are triterpenoid compounds arundoin, cylindrin, taraxerol and free It contains delrin, and the ground portion also contains phenolic fats, amino acids, organic acids, and sugars. Bamboo leaves have a sweet, sour, and cold nature. They treat swollen gums, painful symptoms and oral infections, quench thirst due to fever, urinate well, and refresh the mind. Bamboo leaves also have the effect of sputum sputum, brightening eyes, lowering heat and detoxifying. Bamboo leaf showed an excellent antipyretic effect when orally administered to artificially heated rats, and it was reported to increase diuretic chloride excretion.
    [38] Bamboo leaves are harvested when the young leaves of cotton swabs are not blossomed in May to June, and the beard roots are removed and dried in the sun. Bamboo leaves have excellent antipyretic and diuretic effects, brighten the eyes, treat swollen gums, painful symptoms and oral inflammation. It is preferable that the antistress agent composition of this invention contains 2.0-40.0 g of bamboo leaves.
    [39] As an alternative medicine for the bamboo leaves, kill, gold, etc. can be used.
    [40] Soybean hwangwon (大豆 黃 卷, leguminosae ) is a germinating black bean, a year-old herb belonging to the legume, generally refers to bean sprouts. Sprouts are foods made by germinating soybeans, but they are much better for our bodies than eating soybeans, and have the effect of preventing and treating various adult diseases. What is noteworthy about soybean sprouts is that they produce vitamin C and vitamin B 2 , which are not found in soybeans, and nisin and vitamin K. In addition, it contains high amounts of minerals such as potassium and calcium and dietary fiber, so bean sprouts are highly regarded as a valuable source of vitamins and minerals. Soybean sprouts have a low digestive absorption rate, but soybean sprouts have digestive enzymes such as amylase and invertase, and thus have high digestive absorption rates, and are plant proteins containing essential amino acids such as lysine, tryptophan, and methionine. . In addition, mung bean sprouts and mung bean sprouts contain a lot of phosphorus and vitamin B 2 of the mineral components, which are easily eluted in water and should be roasted in oil. Low-calorie and bulky bean sprouts are gaining popularity as a dietary food. Cooking with other vegetables consumes a lot of fiber, which is known to be effective for improving the health of the intestines.
    [41] Soybean yellow soybeans are soaked in soybean sprouts for about a day, germinated, and then dried for 5 days at room temperature in a cool place. The soybean yellow area gives mental and physical vitality, and it cures hangover, abdominal pain, diarrhea and skin disease caused by hangover effect and cold. It is preferable that the antistress agent composition of this invention contains 2.0-40.0 g of soybean yellow roll.
    [42] Baekdu-gu, blackdugu, white-migraine and the like may be used as an alternative medicine of the soybean rhubarb.
    [43] Ginger (生 다, rhizoma zingiberis ) is a perennial herb belonging to the family of ginger, and is used in oriental medicine and seasonings regardless of the East or West, and is a food that has a great effect on health as well as flavor. Ginger, in particular, exhibits anti-ulcer activity, which contains the same ingredients as the chemical gastric ulcer drugs on the market. The mixture of 6-ginzetol and 26-ginzetol, which is the essential oil component of ginger's spicy taste, functions to increase bile secretion by 1.3 times to promote digestion and absorption of fat. In addition, ginger suppresses nausea and vomiting, promotes bowel movements, helps constipation, and prevents diarrhea. It is also known to sterilize anniches that invade and cause agitation.
    [44] Ginger, which exhibits strong antioxidant activity with vitamin E, vitamin C, beta-carotene, and green tea, may have the same or stronger potency as synthetic drugs, and may have synergistic effects with other ingredients. It is a natural medicine that has no side effects at all.
    [45] Ginger is dug up in the summer to remove the stems, leaves, and beard roots. Ginger acts on the digestive system to relieve vomiting and to communicate with the phlegm, induces excitability in the vascular and respiratory centers, and has antimicrobial and antigenic effects. It is preferable that the antistress agent composition of this invention contains 2.0-40.0g of ginger.
    [46] Sessin, health, rich and the like can be used as an alternative medicine of the ginger.
    [47] Chongbaek ( 白, bulbus allii fistulosi ) is a perennial herb that belongs to the family Liliaceae , which is a panacea for the tonsils, longitudinal pain, headache, kidney disease, cold, nervous breakdown, insomnia, fever and diarrhea. It is up. Currently, green onion is used only as a food ingredient in Korea, but it has been developed and used as a medicine in the United States, Japan, and Europe including China.
    [48] The hot component of the leek is by allyl sulfide, which is present in the form of glycosides in living organisms, which are destroyed by the action of enzymes and are evaporated by heating. . Green onions contain large amounts of water, but when they are dry they contain a large amount of amino acids, including 30% of arginin, which enters the body to break down fats and restore fatigue and strengthen mental power. It contains about 30% of glutamine, which promotes the development of bacteria, detoxifies harmful substances in the brain, and helps with fat metabolism.
    [49] Chongbaek washes off the dirt and cleansed it. Chongbaek is a fever, headache, abdominal pain, stool irritation, dysentery, swelling to treat the large intestine, and muscle spasm caused by ovulation, each is effective. It is preferable that the antistress agent composition of this invention contains 2.0-40.0 g of total bags.
    [50] Ephedra, leaflets and the like can be used as an alternative medicine of the total bag.
    [51] Red pepper contains capsacin to give it a spicy taste, and it contains carotene, which is a pigment, to combine with fatty acids as the blue pepper matures, oxidizing to capsanthin to give a deep red color. Indicating become red pepper. Ingestion of capsaicin in moderation is effective for food intake, warmth, intestinal sterilization, etc. In hot countries, people do not eat heat as a vital source of energy, people in cold countries are eating red peppers to warm the body.
    [52] In oriental medicine, red pepper has the effect of improving eyesight, and it is widely introduced as a folk remedy that helps the body's blood circulation by active digestion by keeping the above activity active, and it is neuralgia by steaming with red pepper powder in folk remedies. It also works to relieve the pain of arthritis and to cure gout or rheumatism. In addition to the red pepper, the effect of promoting metabolism, strengthening of the fascia membrane, etc. and smooth the flow of lymph.
    [53] Chili peppers are picked ripe red peppers in autumn, dried in the sun and wiped clean with a dry towel one by one. It is preferable that the antistress agent composition of this invention contains 2.0-40.0g of red peppers.
    [54] Ginger, Giltyeong, etc. may be used as an alternative medicine of the red pepper.
    [55] In another aspect, the present invention provides a pharmaceutical composition having the anti-stress agent composition as an active ingredient having a stress prevention and treatment effect.
    [56] Formulation method of the anti-stress agent composition of the present invention can be carried out by conventional methods known in the art, it is possible to formulate in the form of tablets, capsules, tablets, soft capsules, solutions, powders, granules and the like.
    [57] In general, agitation is also called premises, which is a kind of liquid formulation. In other words, put water in the medicine and heat for a while, then throw away the residue and use only the water that comes out as a medicine. Acupuncture is the most widely used formulation of herbal medicines. It has the advantages of easy absorption, rapid therapeutic effect, and simple preparation process. It is preferable to use a container such as porcelain, enamel, etc., made of clay. This is to prevent the medicinal herbs containing components such as tannins and organic acids from causing a change reaction and affecting the medicinal effects. It is not preferable to use a device made of iron or motives.
    [58] In addition, it is preferable to use a bag made of mineral wood, etc. as a medicine bag used when putting the medicinal herbs in the herbal extractor, because the mineral wood does not cause the chemical reaction of the medicine to properly filter out the fine particles.
    [59] In this way, the extract of the sugar liquid, which is chopped in the herbal medicine extractor is vacuum-packed so that it is easy to eat as much as the amount to be eaten at a time by extracting only the liquid component using an automatic packaging machine.
    [60] On the basis of the above-described general method for producing a demulsifier, a method for producing demulsifiers of the antistress agent composition of the present invention is
    [61] 1) weighing the weight of the medicinal composition of the prescription on a scale, and then immersing the remaining medicinal herbs except pepper and baekbaek in water;
    [62] 2) extracting the medicinal liquid by pouring the medicinal herbs of step 1 into a furoshiki, adding total bag and red pepper in the amount added, and then pouring water into a preheated herbal extractor and heating it;
    [63] 3) It is composed of the step of packaging the amount of liquid to be taken once by moving the extracted liquid solution to the automatic packaging machine as described above.
    [64] The process of immersing the medicinal herbs in water in step 1 is suitable for about 30 minutes to 1 hour, which is to facilitate the active ingredients of the medicinal herbs.
    [65] In step 2, it is preferable to use a cloth made of gwangbok, and water is extracted by heating about 1 hour and 30 minutes by adding 4000 cc of water per 500 g of dry medicine.
    [66] In step 3, the pressure of the extractor is raised instantaneously, and a valve for the automatic packing machine is opened to move only the extracted hot liquor to the packing machine so that the residue remains in the extractor.
    [67] A pill refers to various granular formulations made by adding a viscosity agent to a fine powder of a medicinal herb, and wheat pill, hydration, and compatibility are mainly used in clinical practice. Pills have the advantages of simple taking, relatively slow absorption of the drug, long lasting efficacy and convenient carrying and storage of the drug.
    [68] Method for producing pill of antistress agent composition of the present invention
    [69] 1) preparing a medicinal mixture by weighing and weighing all of the constituent medicinal ingredients in a prescription in a scale, then finely powdering and evenly mixing them;
    [70] 2) heating and filtering the honey, heating again, and then repeating three or four times of filtration to continue heating until it turns yellow with a light fire;
    [71] 3) when step 2 is completed, kneading by adding the herbal mixture of step 1 to hot honey;
    [72] 4) molding the dough of step 4 into rings of equal size using an artificial or machine; And
    [73] 5) The ring of step 4 is dried in a cool and dry place and then stored in a cool place closed.
    [74] In step 1, powder each of the constituents, put them together, put them back into the powder machine, and repeat the process several times so that the respective medicines are evenly mixed.
    [75] In step 2, honey is prepared at about 250 cc per 500 g of powdered medicine, water, hodo oil, and vinegar can be used instead of honey, and it can be picked up by hand to be viscous, yellow dusty, and not sticky even after cooling. Heat until no longer
    [76] Capsules of the anti-stress agent composition of the present invention was prepared by lyophilizing the type of powder produced by the above-mentioned type of powder preparation and putting it in the capsule in an appropriate amount.
    [77] On the other hand, the pharmaceutical composition of the present invention is selected in the conventional pharmaceutical formulation by selecting one or two or more pharmaceutically acceptable conventional carriers and one or two or more additives in an effective amount of the antistress agent composition as the main component. Manufacture.
    [78] The carrier may be used by selecting one or two or more from diluents, lubricants, binders, disintegrants, sweeteners, stabilizers, and preservatives, and one or two or more of the fragrances, vitamins, and antioxidants. The pharmaceutical preparation of the present invention can be used orally in preparation as a powder, pill, tablet, capsule, soft capsule, liquid, powder, granule, and the like.
    [79] In the present invention, the carrier and the additive may be used in any pharmaceutically acceptable, and specifically, as a diluent, lactose monohydrate, corn starch, cornbean oil, soybean oil, microcrystalline cellulose Or mannitol (D-mannitorl) is preferable, magnesium stearate or talc is preferred as a lubricant, and polyvinylpyrrolidone (PVP) or hydroxypropyl cellulose (HPC; hydroxypropylcellulose). In addition, the disintegrant may be selected from among carboxymethylcellulose calcium (Ca-CMC; carboxymethylcellulose calcium), sodium starch glycolate, polacrylin potassium, and cross-linked polyvinylpyrrolidone. Preferably, the sweetener is selected from sucrose, fructose, sorbitol or aspartame, and the stabilizer is carboxymethylcellulose sodium (Na-CMC), beta-cyclodextrin, It is selected from white bee's wax or xanthan gum, and preservatives include methyl p-hydroxy benzoate, methylparaben, propyl p-hydroxy benzoate, propylparaben or potassium sorbate. It is preferable to select from (potassium sorbate).
    [80] In addition to the above main components, the pharmaceutical composition of the present invention may use mineral-containing compounds such as vitamins B, C, E, beta carotene, Ca, Mg, and Zn, phospholipids such as lecithin, or compounds such as maltol and amino acids. Among them, the use of a mixture of two or three components of vitamin C, E or beta carotene, maltol, etc. is more preferable because it can increase or enhance the biological activity effect.
    [81] In addition to the above ingredients, in order to enhance the taste as a known additive, natural flavors such as plum, lemon, pineapple or herb, or natural fruit juice, natural pigments such as chlorophyllin, flavonoids, and fructose, sweet sugars, It may be used by mixing an acidulant such as citric acid and sodium citrate with beehives, sugar alcohols and sugars.
    [82] In general, in order to obtain a preventive and therapeutic effect of the desired stress in medicine, as an active ingredient, the antistress composition is an anti-stress agent so that the total daily amount is 30 to 140 g, preferably 40 to 60 g, based on the weight of 60 kg adult. It is preferable to orally administer a pill, capsule, tablet, soft capsule, liquid, granule, or powder several times.
    [83] The antistress agent composition of the present invention is widely used as a medicinal herb, and contains a medicinal plant well known in its ingredients and toxicity data as an active ingredient, so the acute toxicity test is meaningless and omitted.
    [84] In addition, the present invention provides a health food having a stress prevention and treatment effect by containing the anti-stress agent composition as an active ingredient.
    [85] As a health food containing the anti-stress agent composition of the present invention, folk remedies such as tea, jelly, juice, juice, extracts, beverages, etc. with the above-mentioned medicinal plants as active ingredients for the purpose of preventing stress and suppressing memory loss, etc. Can be mentioned.
    [86] The anti-stress and memory deterioration inhibitory effect of the antistress agent composition of the present invention prepared as described above was confirmed through animal experiments. The effect of the liquid extract extract of the antistress composition of the present invention and stress on the experimental animals trained by the Morris water maze experiment was measured by the time required to arrive at the arrival point and the change in the number of visits to the arrival point. In the normal state, however, the experimental animals remembered the arrival points learned after 20 times of training even after 6 weeks, but the memory was significantly decreased due to external physical stress lasted for 6 weeks. However, this memory loss phenomenon is that the drug administered with the external physical stress suppresses the decrease in memory caused by stress, so that the extract of the liquid extract of the antistress agent composition of the present invention suppresses the memory decrease caused by stress and restores memory Confirmed effective
    [87] Taken together, the antistress agent composition of the present invention has a synergistic effect due to the mixing composition of the main active ingredient is administered to the experimental animal showing a decrease in learning ability and memory by physical stress from the outside It was confirmed that excellent antistress effect was obtained by suppressing learning ability and memory decline and restoring memory.
    [88] Hereinafter, the present invention will be described in detail by way of examples.
    [89] However, the following examples are merely to illustrate the invention, but the content of the present invention is not limited to the following examples.
    [90] Example 1 Preparation of Pharmaceutical Composition for Antistress; Prosperity
    [91] <1-1>
    [92] In order to prepare a pharmaceutical composition containing the anti-stress agent composition of the present invention as an active ingredient, malt 5.0 g, base paper 3.0 g, baeksinsin 3.0 g, bamboo leaf 3.0 g, soybean yellow roll 3.0 g, ginger 2.0 g, total white 2.0 After weighing g and 2.0 g of red pepper in the amount of the balance, the medicines were immersed in water for 30 minutes to 1 hour, except for pepper and baekbaek, so that the active ingredients of the medicine came out easily.
    [93] After immersing the medicinal herbs from the water, put them in a furoshiki, add the total bag and red pepper in the amount, and pour water into a preheated Chinese herbal extractor and heat the extract. At this time, the furoshiki is preferably used to be made of gwangbok, and water is extracted by heating about 1 hour 30 minutes by adding 4000 cc of water per 500 g of dry medicine.
    [94] In order to move the extracted sugar solution to the automatic packing machine as described above, the pressure of the extractor was momentarily raised, and then the valve was opened to the automatic packing machine to move only the extracted sugar solution to the packing machine, and then packaged in a quantity to be taken once. It was left in the extractor.
    [95] <1-2>
    [96] The constituent medicaments of the anti-stress agent composition were malted 20.0 g, raw paper 16.0 g, white baeksin 16.0 g, bamboo leaf 16.0 g, soybean rhubarb 15.0 g, ginger 10.0 g, total white 10.0 g, and red pepper 8.0 g. In the same manner as &gt;
    [97] <1-3>
    [98] The composition of the anti-stress agent composition is 20.0 g of malt, 16.0 g of sanjoin, 16.0 g of baekxin, kill 16.0 g, 15.0 g of soybean yellow rye, 10.0 g of sesame, 10.0 g of total white, and 8.0 g of long diameter. In the same manner as in the preparation of the pouring.
    [99] <1-4>
    [100] The composition of the anti-stress agent composition is 20.0 g of new song, 16.0 g of original paper, 16.0 g of Baekbokyeong, 16.0 g of bamboo leaf, 15.0 g of Baekdugu, 10.0 g of ginger, 10.0 g of ephedra and 8.0 g of red pepper. In the same manner as in the preparation of the pouring.
    [101] <1-5>
    [102] The compositional medicines of the antistress agent composition were made into 20.0 g of new song, 16.0 g of Sanjoin, 16.0 g of Baekbokryeong, 16.0 g of kill, 15.0 g of Baekdugu, 10.0 g of sesame, 10.0 g of ephedra, and 8.0 g of Gil length. In the same manner, the tang was prepared.
    [103] <1-6>
    [104] The constituent medicines of the anti-stress agent composition were 20.0 g of sine, 16.0 g of Seokchangpo, 16.0 g of Baekbokyeong, 16.0 g of black power, 15.0 g of black soybean, 10.0 g of healthy, 10.0 g of lobules, and 8.0 g of the above diameter. In the same manner, the tang was prepared.
    [105] <1-7>
    [106] The constituent medicines of the antistress agent composition were made of 20.0 g of hawthorn, 16.0 g of zojoin, 16.0 g of baeksin, 16.0 g of golden flakes, 15.0 g of migraine, 10.0 g of rich man, 10.0 g of lobule, and 8.0 g of long diameter. In the same manner as in the preparation of the pouring.
    [107] Example 2 Preparation of Pharmaceutical Composition for Antistress; Pill
    [108] <2-1>
    [109] To prepare a pharmaceutical composition containing the anti-stress agent composition of the present invention as an active ingredient as a pill, malt 5.0 g, base paper 3.0 g, baekxin 3.0 g, bamboo leaf 3.0 g, soybean yellow roll 3.0 g, ginger 2.0 g, total white 2.0 g and 2.0 g of red pepper were weighed into the balance, and each powder was finely powdered and mixed evenly to prepare a medicinal mixture. At this time, each of the medicinal herbs to make a powder, put them all together again and put them back into the powder machine was repeated several times to make each of the medicinal herbs evenly mixed.
    [110] Heat honey prepared at around 250 cc per 500 g of powdered medicine, filter, heat again, filter again, and then repeat three or four times, then pick it up by hand and rub it to make it viscous, yellow sand, and not sticky even after cooling. Heated until no more. Water, lake oil and vinegar may be used instead of honey. The medicine was added to the hot honey prepared in this way and kneaded to prepare a pill by molding the dough into a ring of equal size using an artificial or a recirculator. The pills were dried in a cool and dry place and then stored in a cool and airtight place.
    [111] <2-2>
    [112] The composition of the anti-stress agent composition is 20.0 g of malt, 16.0 g of raw paper, 16.0 g of baekxin, 16.0 g of bamboo leaf, 15.0 g of soybean rhubarb, 10.0 g of ginger, 10.0 g of ginseng, and 8.0 g of red pepper. Pills were prepared in the same manner as>.
    [113] <2-3>
    [114] The composition of the anti-stress agent composition is 20.0 g of malt, 16.0 g of sanjoin, 16.0 g of baekxin, 16.0 g of kill, 15.0 g of soybean rhubarb, 10.0 g of sesame, 10.0 g of ginseng, and 8.0 g of long diameter. In the same manner as in the preparation of pills.
    [115] <2-4>
    [116] The composition of the antistress agent composition is 20.0 g of new song, 16.0 g of original paper, 16.0 g of Baekbokryeong, 16.0 g of bamboo leaf, 15.0 g of Baekdugu, 10.0 g of ginger, 10.0 g of ephedra and 8.0 g of red pepper. In the same manner as in the preparation of pills.
    [117] <2-5>
    [118] The composition of the anti-stress agent composition is 20.0 g of new song, 16.0 g of Sanjoin, 16.0 g of Baekbokryeong, 16.0 g of kill, 15.0 g of Baekdugu, 10.0 g of sesame, 10.0 g of ephedra, and 8.0 g of Gil length. Pills were prepared in the same manner.
    [119] <2-6>
    [120] The constituent herbs of the anti-stress agent composition were 20.0 g of sine, 16.0 g of Seokchangpo, 16.0 g of Baekbokyeong, 16.0 g of black power, 15.0 g of black soybean, 10.0 g of healthy, 10.0 g of lobule, and 8.0 g of L. p. Pills were prepared in the same manner.
    [121] <2-7>
    [122] The composition of the anti-stress agent composition is 20.0 g of hawthorn, 16.0 g of sanjoin, 16.0 g of baeksin, golden 16.0 g, 15.0 g of migraine, 10.0 g of rich man, 10.0 g of lobule, and 8.0 g of long diameter. In the same manner as in the preparation of pills.
    [123] Example 3 Preparation of Pharmaceutical Composition for Antistress; Capsule
    [124] The capsules of the antistress agent composition of the present invention are freeze-dried in the above-mentioned examples <1-1> to <1-7>, and then mixed with an excipient, and a capsule of 222 mg by weight of 1 capsule by weight. It was prepared by the manufacturing method.
    [125] Example 4 Preparation of Pharmaceutical Composition for Antistress; Soft Capsule
    [126] Soft capsules of the anti-stress agent composition of the present invention after freeze-drying the powders prepared in Examples <1-1> to <1-7> and the excipients were mixed to weigh the weight of one capsule 324.3 mg each It was prepared by a soft capsule manufacturing method.
    [127] Example 5 Preparation of Pharmaceutical Composition for Antistress; Liquid
    [128] The solution of the antistress agent composition of the present invention is prepared by adding an excipient to the hot water prepared in Examples <1-1> to <1-7> above, followed by dissolving, and adding purified water to make the final amount 10 liter. It was prepared by.
    [129] Example 6 Preparation of Pharmaceutical Composition for Antistress; Powder
    [130] The powder of the anti-stress agent composition of the present invention was added to the hot water prepared in Examples <1-1> to <1-7>, followed by drying with an excipient, and then the weight per one packet by the conventional powder preparation method. Prepared.
    [131] Experimental Example 1 Preparation of Experimental Animals, Drug Administration and Stress
    [132] 7-week-old ICR male mice Morris won the maze experiment (for animals (week), voice, Chungbuk) (Morris water maze test, Redish , AD and Touretzky, DS, The role of the hippocampus in solving the Morris water maze. Neural computation, 10: 73-111, 1998; Moriguchi, T., Saito, H., and Nishiyama, N., Aged Garlic extract prolongs longevity and Improves spatial memory deficit insenescence-accelerated mouse.Bio.Pham.Bull ., 19: 305-307, 1996) and then well-educated individuals were selected and used as experimental animals, and these were administered with a control group not administered the liquid extract of Examples <1-1> to <1-7>. After dividing into the experimental group, the experiment was divided into four groups, each divided into a stressed group and a non-stressed group as follows.
    [133] 1) the control group (Cont-Not) not receiving the stress extract without stress
    [134] 2) a control group (Cont-Stress) that was stressed and did not receive a liquid extract,
    [135] 3) the experimental group (Treat-Not) to administer the liquid extract without stress,
    [136] 4) The experimental group (Treat-Stress) under the stress and administration of the liquid extract.
    [137] Ten to twelve animals were used in each group, and medicinal herbs were orally administered with medicinal herb extracts (Sugar extracts of Examples <1-1> to <1-7>) at a dose of 8 g / kg / day per dry medicinal herb. . The liquid extract of medicinal herbs was stored frozen in aqueous solution and administered, and the control group was orally administered with the same amount of water. Stressing was carried out by placing the animals in a frame large enough to fit the animals into the stress, and giving them stress for 15 minutes / day for 6 weeks. The liquid extract extract and stress were administered in the same period. After 6 weeks, all anesthetized with ether and all organs were extracted after taking the total amount of blood collected by heparinized syringe in the posterior vein. The collected blood was used for complete blood cell count (CBC count), and plasma was separated by centrifugation at 10,000 rpm (eppendorf 5402 centrifuge) at 4 ° C for 10 minutes. Extracted organs and separated plasma were stored at -70 ° C.
    [138] Experimental Example 2 Education of Experimental Animals
    [139] In order to verify the memory of experimental animals, Morris water maze experiments were performed to educate experimental animals. A cylindrical tank of 120 cm in diameter filled the water so that the arrival point (outlet) was submerged 5 mm below the surface of the water, and 6 liters of milk was added to the tank to make the arrival point invisible. Indirect illumination was used to rule out visual direction. The experimental animals were dropped in the opposite direction to the arrival point of the tank, and then the movement, speed, and landing of the arrival point were observed through the installed video. The maximum swimming time was 2 minutes and 30 seconds, and if the arrival point could not be found within that time, it was artificially landing at the arrival point for 5 seconds to teach that the arrival point was located at a straight distance from the position where it entered the tank. A total of 20 training sessions were conducted, from which well-trained individuals were selected and embarked on animal experiments. After six weeks of dosing and stress treatment, Morris water maze experiments were conducted four times to observe the learning memory prior to dosing and stress application.
    [140] The results were compared between the last four (17, 18, 19 and 20) of the 20 well-trained individuals and the four trainings 6 weeks after the sugar extract and stress. Two comparisons were made: the time taken to reach the arrival point (sec) and the frequency of finding the arrival point. Each result was tested by t-test, ANOVA-test, Bonferroni multiple comparison, and Fisher's least-significant-difference test. Or, it was judged that there was a significant difference that the difference before and after administration was p <0.05.
    [141] Experimental Example 3 Measurement of Weight Change by Administration of Extracts and Stress
    [142] After training the experimental animals 20 times in the Morris water maze experiment, the weight of each group was measured every week for 6 weeks before and after stressing while administering the extract of Example <1-1>, and is shown in Table 1 and FIG. 1 .
    [143] <Table 1> Weight change of each group according to the administration period
    [144] Period of administration (weeks)Cont-notCont-tressTreat-NotTreat-Stress 035.76 ± 1.1335.82 ± 0.7336.95 ± 0.4836.09 ± 0.72 One37.11 ± 1.0836.28 ± 0.8737.60 ± 0.4635.98 ± 0.56 237.73 ± 0.8736.01 ± 0.7538.08 ± 0.4035.78 ± 0.63 338.79 ± 1.1636.69 ± 0.9538.80 ± 0.4636.03 ± 0.63 440.32 ± 1.1535.44 ± 0.64 # 39.63 ± 0.86 * 35.78 ± 0.82 #541.27 ± 1.01 * 38.02 ± 0.9539.75 ± 0.49 ** 37.18 ± 0.61 ##641.19 ± 0.97 * 38.16 ± 0.9139.83 ± 0.45 ** 37.23 ± 0.49 ##
    [145] Comparison with Bonferroni multiple comparison method,
    [146] * Compared to 0W of each group; p <0.05, **; p <0.01,
    [147] Compared to Cont-Not group in each week of age #; p <0.05.
    [148] In the control group, the stress-free group (Cont-Not) showed a significant increase in body weight from the 5th week after the liquid extract was administered (p <0.05), compared to before the liquid extract (0 week). Group (Treat-Not) showed significant body weight gain (p <0.05, p <0.01) from the 4th week of the administration of the extract, whereas the stress-treated groups (Cont-Stress and Treat-Stress) of the control and experimental groups were There was no increase in body weight during the six week period prior to administration. These results indicate that the body weight increases with the increase of the age at steady state, and that the administration of the liquid extract has no effect on the increase of the body weight with the increase of the age. The increase in body weight accordingly is suppressed and administration of the juice extract has no effect on this inhibition. The liquid extract of Examples <1-2> to <1-7> also showed the same results as above.
    [149] Experimental Example 4 Measurement of Whole Blood Cell Change by Infusion of Stress Solution and Stress
    [150] Six weeks after the administration of the sugar extract and stress application, the whole blood cell counts of blood collected from all experimental animals were measured to determine whether the immune system was abnormal and the hematopoietic function was abnormal due to the administration of the juice extract and stress application. To this end, the number of leukocytes, lymphocytes, monocytes, granulocytes, and erythrocytes was measured from the extract obtained from the experimental animals without or without stress while administering the extract of Example <1-1>, and the hemoglobin and erythrocyte volume ratios were measured. The results are shown in Table 2 below.
    [151] <Table 2> Changes in Whole Blood Cell Counts after Administration of Extracts and Stress
    [152] Cont-notCont-tressTreat-NotTreat-Stress leukocyte4.00 ± 0.932.30 ± 0.472.77 ± 0.472.97 ± 0.37 Lymphocyte3.28 ± 0.751.38 ± 0.182.11 ± 0.362.20 ± 0.27 Monocytes0.40 ± 0.110.70 ± 0.430.51 ± 0.090.61 ± 0.10 Granulocyte0.30 ± 0.120.30 ± 0.160.16 ± 0.060.15 ± 0.03 Red blood cells8.51 ± 0.238.55 ± 0.218.60 ± 0.128.93 ± 0.20 hemoglobin14.56 ± 0.3414.51 ± 0.2814.26 ± 0.1914.76 ± 0.26 Erythrocyte volume fraction (%)42.12 ± 1.0742.67 ± 0.7442.43 ± 0.5143.94 ± 0.80
    [153] As shown in Table 2 , as a result of measuring the whole blood cell count, there was no change in immune system and hematopoietic function due to administration of stress extract and stress application. Examples 1 to 2 The liquid extract of showed the same result.
    [154] Experimental Example 5 Measurement of Changes in Arrival Time by Administration of Liquid Extracts and Stress
    [155] The present inventors performed the final four times of the Morris water maze experiment conducted before the administration of the liquid extract using the liquid extract of Example <1-1> and four times the Morris water maze performed 6 weeks after the administration of the liquid extract. The experimental results are shown in Table 3 by showing the time required for the experimental animals to reach the arrival point.
    [156] <Table 3> Change in arrival time (sec) due to the administration of the liquid extract extract and stress.
    [157] Before the liquid extract6 weeks after administration of liquid extract Cont-not75.24 ± 8.5969.95 ± 8.53 Cont-stress61.41 ± 7.5997.43 ± 8.18 ** $$Treat-not42.36 ± 6.0249.55 ± 6.89 Treat-stress49.30 ± 6.2954.77 ± 7.12 ## &&
    [158] comparing 0 and 6 weeks of each group in the t-test **; p <0.01,
    [159] Comparison of Cont-Stress and Treat-Stress in t-test ##; p <0.01,
    [160] Compare week 0 and week 6 in the ANOVA test $$; p <0.01,
    [161] Comparison of Cont-Stress and Treat-Stress in ANOVA Test &&; p <0.01.
    [162] In the non-stressed group, the Morris water maze experiment before and after 6 weeks of administration of the sugar extract showed that the time required for finding the arrival point was 75.24 ± 8.59 sec and 69.95 ± 8.53 sec. However, in the stressed group for 15 minutes daily, the time taken to find the point of arrival was significantly increased to 61.41 ± 7.59 seconds and 97.43 ± 8.18 seconds after 6 weeks of injection of the extract (p <0.01). ). On the other hand, in the non-stressed group, the time required for finding the arrival point before and after 6 weeks of administration of the sugar extract was 42.36 ± 6.02 seconds and 49.55 ± 6.89 seconds. There was no significant change at 6.29 seconds and 54.77 ± 7.12 seconds. In other words, the ICR mouse was able to remember the arrival point learned after 20 times of training even after 6 weeks in the normal state, but it was shown that the learned memory was greatly degraded due to external physical stress lasted for 6 weeks. However, this memory loss phenomenon is that the liquid extract administered together with the external physical stress suppresses the decrease in memory caused by stress, so that the antistress composition of the present invention is effective in suppressing the memory decrease caused by stress and restoring memory. Confirmed that
    [163] Experimental Example 6 Measurement of the Change in the Number of Finding Arrival Points by Administration of the Liquid Extract and Stress
    [164] The final four results of the 20 Morris water maze experiments conducted prior to administration and stress application, and the four water maze experiments conducted six weeks after administration and application of stress extract were placed within 2 minutes and 30 seconds. In total, it is shown in Table 4 below.
    [165] <Table 4> Number of arrivals of each group before and after administration of liquid extract
    [166] Before administration of liquid extract6 weeks after administration of liquid extract Cont-not3.18 ± 0.263.46 ± 0.16 Cont-stress3.42 ± 0.152.42 ± 0.38 *Treat-not3.73 ± 0.143.55 ± 0.25 Treat-stress3.70 ± 0.153.70 ± 0.15 #
    [167] t-test before and after 6 weeks of administration, *; p <0.05.
    [168] comparing Cont-Stress and Treat-Stress with a t-test, #; p <0.05
    [169] As a result of measuring the number of landings at the arrival point of the tank within 2 minutes and 30 seconds, which is the reference time of the Morris water labyrinth experiment, there was no change in the number of arrival points before the injection of the extract and after 6 weeks of the injection of the extract. In the stressed group, 3.42 ± 0.15 times before the liquid extract was administered 2.42 ± 0.38 after 6 weeks, which significantly reduced the number of destinations (p <0.05). On the other hand, in the unstressed group, there was no change in the number of arrival points before and after the administration of the sugar extract, as in the normal state. There was no change in the number of times found. In addition, comparing the stress-treated group (Cont-Stress) with the liquid extract and the stress-treated group (treat-Stress) without the liquid extract was compared, the number of finding the arrival point between the two groups before the liquid extract was administered. There was no significant difference, but after 6 weeks of administration of the sugar extract, the number of finding the arrival point was increased in the group in which the liquid extract was administered and the stress was given (p <0.05). The liquid extract of Examples <1-2> to <1-7> also showed the same result.
    [170] Thus, these results indicate that physical stress applied externally decreases the learned memory and reduces the number of times of finding the arrival point, but this reduction can be normalized by administration of the antistress agent composition of the present invention.
    [171] Based on the above results, the experimental animal exhibited a decrease in learning ability and memory due to physical stress from the outside, but this learning ability and memory loss was suppressed by the administration of the antistress crude fiber of the present invention. You can see that.
    [172] As described above, the antistress agent composition of the present invention exhibits excellent pharmacological effects on the prevention and treatment of stress, as well as effectively inhibits memory loss caused by excessive stress, and thus can be usefully used as a stress prevention and treatment agent. In addition, it can be applied as a health food has proved to be an industrially useful invention.
    权利要求:
    Claims (16)
    [1" claim-type="Currently amended] At least one medicinal herb selected from the group consisting of malt ( fructus hordel germintus ), new song ( mesok medicata fermentata ), sine ( 砂仁 , fructus amomi ), and sansa (mountain company, fructus crataegei ) 2.0-40.0 g, radix polygalae ( 원 志 , radix polygalae ), Sanjoin ( 酸棗仁 , semen zizyphi spinosae ) and Seokchangpo (石菖 浦, rhizoma acori graminei ) 2.0 to 40.0 g or more selected from the group consisting of poria holen ) and one or more medicinal herbs selected from the group consisting of poria ( poria ) 2.0-40.0 g, bamboo leaf ( folium phyllostachyos ), kill (竹茹, calus in taein phyllostachyos ), killing force ( 2.0-40.0 g of one or more medicinal herbs selected from the group consisting of 竹瀝, succus phyllostachyos ) and golden ( radix scutellariae ), rhubarb wang (大 um 黃 卷, leguminosae ), baekdu ( fructus amomi cardamomi ), heukdaedu (黑大豆, semen glycine) and Lentils (白篇豆, semen lablab) 1 jong medicinal 2.0 to 40.0 g or more selected from the group, ginger (生薑, zingiberis rhizoma), slender (細辛, radix asari) consisting of healthy (乾薑, zingiberis rhizoma siccatum ) And at least one medicinal herb 2.0-40.0 g selected from the group consisting of rich (附子, radix aconiti ), ginseng ( bulbus allii fistulosi ), ephedra ( herba ephedrae ) and lobule ( folium perillae) A mixture of 2.0 to 40.0 g of one or more medicinal herbs selected from the group consisting of 1) and 2.0 to 40.0 g of one or more medicinal herbs selected from the group consisting of red pepper and radix platycodi An antistress composition comprising as a component.
    [2" claim-type="Currently amended] 2. Malt 2.0-40.0 g, raw paper 2.0-40.0 g, Baeksin 2.0-40.0 g, bamboo leaf 2.0-40.0 g, soybean rhubarb 2.0-40.0 g, ginger 2.0-40.0 g, total white 2.0-40.0 g, and red Anti-stress composition comprising a mixture consisting of red pepper 2.0 to 40.0 g as an active ingredient.
    [3" claim-type="Currently amended] The malt 2.0-40.0 g, sanjoin 2.0-40.0 g, baeksincin 2.0-40.0 g, 2.0-40.0 g of killing, 2.0-40.0 g of soybean paste, 2.0-40.0 g of sesame, 2.0-40.0 g, total white 2.0-40.0 g, and Gilkyung of Claim 1 An antistress agent composition comprising a mixture consisting of 2.0 to 40.0 g as an active ingredient.
    [4" claim-type="Currently amended] The method according to claim 1, 2.0-40.0 g of new song, 2.0-40.0 g of raw paper, 2.0-40.0 g of Baekbokryeong, 2.0-40.0 g of bamboo leaf, 2.0-40.0 g of Baekdugu, 2.0-40.0 g of ginger, 2.0-40.0 g of ephedra and red pepper An antistress agent composition comprising a mixture consisting of 2.0 to 40.0 g as an active ingredient.
    [5" claim-type="Currently amended] 2. New song 2.0-40.0 g, Sanjoin 2.0-40.0 g, Baekbokryeong 2.0-40.0 g, Kill 2.0-40.0 g, Baekdugu 2.0-40.0 g, Secinin 2.0-40.0 g, Ephedra 2.0-40.0 g, and Gil length 2.0 An antistress agent composition comprising a mixture consisting of ~ 40.0 g as an active ingredient.
    [6" claim-type="Currently amended] The method according to claim 1, 2.0 to 40.0 g of sine, 2.0 to 40.0 g of Seokchangpo, 2.0 to 40.0 g of Baekbokyeong, 2.0 to 40.0 g of bamboo, 2.0 to 40.0 g of black soybean, 2.0 to 40.0 g of health, 2.0 to 40.0 g of lobule 2.0 An anti-stress composition comprising a mixture consisting of ~ 40.0 g as an active ingredient.
    [7" claim-type="Currently amended] 2. The litter 2.0 to 40.0 g, Sanjoin 2.0 to 40.0 g, Baeksin 2.0 to 40.0 g, Golden 2.0 to 40.0 g, Baekdu 2.0 to 40.0 g, Rich 2.0 to 40.0 g, Small leaf 2.0 to 40.0 g and Gil length An antistress agent composition comprising a mixture consisting of 2.0 to 40.0 g as an active ingredient.
    [8" claim-type="Currently amended] The anti-stress composition according to claim 1, wherein the dosage form is selected from the group consisting of water preparations, pills, tablets, capsules, soft capsules, solutions, granules and powders.
    [9" claim-type="Currently amended] The method of claim 8, wherein
    1) weighing the weight of the medicinal composition of the prescription on a scale, and then immersing the remaining medicinal herbs except pepper and baekbaek in water;
    2) extracting the medicinal liquid by pouring the medicinal herbs of step 1 into a furoshiki, adding total bag and red pepper in the amount added, and then pouring water into a preheated herbal extractor and heating it;
    3) The anti-stress composition, characterized in that it is manufactured by the step of packaging the extracted liquid solution as an amount to be taken once by moving to an automatic packaging machine.
    [10" claim-type="Currently amended] The method of claim 8, wherein the pill
    1) preparing a medicinal mixture by weighing and weighing all of the constituent medicinal ingredients in a prescription in a scale, then finely powdering and evenly mixing them;
    2) heating and filtering the honey, heating again, and then repeating three or four times of filtration to continue heating until it turns yellow with a light fire;
    3) when step 2 is completed, kneading by adding the herbal mixture of step 1 to hot honey;
    4) molding the dough of step 4 into rings of equal size using an artificial or machine; And
    5) The anti-stress composition, characterized in that it is prepared by the step of drying the ring of step 4 in a cool dry place and then airtight storage in a cold place.
    [11" claim-type="Currently amended] 11. A pharmaceutical composition according to claim 10, wherein water, lake oil or vinegar can be used instead of the honey of step 2.
    [12" claim-type="Currently amended] 9. The antistress composition of claim 8, wherein the capsule is prepared by lyophilizing the anti-stress agent composition in a capsule by an appropriate amount.
    [13" claim-type="Currently amended] An antistress preventive and therapeutic agent using a pharmaceutical composition comprising the antistress agent composition of claim 1 as an active ingredient.
    [14" claim-type="Currently amended] A memory loss preventing agent and a therapeutic agent using the pharmaceutical composition containing the anti-stress agent composition of claim 1 as an active ingredient.
    [15" claim-type="Currently amended] Health food effective for the prevention and treatment of anti-stress using a pharmaceutical composition containing the anti-stress agent composition of claim 1 as an active ingredient.
    [16" claim-type="Currently amended] A health food effective for preventing and treating memory loss using a pharmaceutical composition containing the antistress agent composition of claim 1 as an active ingredient.
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    同族专利:
    公开号 | 公开日
    KR100373501B1|2003-02-25|
    US20020054920A1|2002-05-09|
    US6416795B1|2002-07-09|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    法律状态:
    2000-09-20|Application filed by 최병학
    2000-09-20|Priority to KR10-2000-0055082A
    2002-03-27|Publication of KR20020022342A
    2003-02-25|Application granted
    2003-02-25|Publication of KR100373501B1
    优先权:
    申请号 | 申请日 | 专利标题
    KR10-2000-0055082A|KR100373501B1|2000-09-20|2000-09-20|An antistress composition for a stress prevention and treatment|
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