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    • 专利摘要:
    The invention relates to a method for preparing a pill organizer (23) comprising a plurality of receiving receptacles for at least one pill, in which: - at least two filling steps are performed in which each filling stage is placed a set of at least one pill in at least one compartment of the pillbox (23) according to data, called filling data, - a step of acquiring an image of the pillbox (23) by a device (24) of image acquisition after at least two filling steps, characterized in that, after at least one acquisition step, called the current acquisition step, a step of controlling the filling of the pillbox (23) in which: An image acquired during said current acquisition step is compared with an image acquired during an acquisition step preceding said current acquisition step, then a conformity of the filling is evaluated.
    公开号:FR3063716A1
    申请号:FR1751996
    申请日:2017-03-10
    公开日:2018-09-14
    发明作者:Michel FOUBET；Gregory FOUBET；Olivier FOUBET
    申请人:Distraimed SARL；
    IPC主号:
    专利说明:

    Holder (s): DISTRAIMED.
    Agent (s): CABINET BARRE LAFORGUE & ASSOCIES.
    Q4 / PROCESS AND DEVICE FOR PREPARING A PILL.
    FR 3,063,716 - A1 57) The invention relates to a method for preparing a pill (23) comprising a plurality of receptacles for receiving at least one pill, in which:
    at least two filling steps in which, at each filling step, a set of at least one pill is placed in at least one housing of the pill box (23) according to data, called filling data,
    - A step of acquiring an image of the pill box (23) by an image acquisition device (24) after at least two filling steps, characterized in that after at least one step of acquisition, known as the current acquisition step, a step of checking the filling of the pill box (23) in which:
    O an image acquired during said current acquisition step is compared to an image acquired during an acquisition step preceding said current acquisition step,
    O then a conformity of the filling is evaluated.

    i
    METHOD AND DEVICE FOR PREPARING A PILL
    The invention relates to a method for preparing a pill container comprising a plurality of receptacles for receiving at least one medicament, known as a pill, in a divided solid dosage form (that is to say in the solid and divided state). , for example chosen from the group formed of tablets, cachets, capsules, capsules, pills, lozenges, dragees; as opposed to a solid mass or compact state such as pasta, ointments ...) - at least not entirely pulverulent or even non-pulverulent-, in which at least one pill is placed in at least one pillbox housing according to data filling a medical prescription for a therapeutic treatment of a patient. The invention also relates to a device for preparing a pill container.
    As part of a therapeutic treatment of a patient, drugs, called pills, in a divided solid dosage form can be dispensed by a nursing staff to the patient according to a medical prescription. This medical prescription notably indicates the dosage, the frequency of taking medication as well as the duration of treatment.
    In order to facilitate the distribution of the drugs to the patient, the pills to be dispensed are generally prepared upstream of the distribution by being gathered in a package, called a pill box, which may comprise a plurality of receptacles for receiving pills (for example as described by FR 2913 333). This preparation step is generally carried out manually by nursing staff.
    During this preparation step, at least one pill is placed in at least one pill box housing according to a medical prescription from a single patient. More particularly, the pill box can be a daily pill box or a weekly pill box for example.
    More particularly, in some pill dispensers, all the pills placed in the same housing are identical, that is to say that they have the same dosage form, the same dosage, the same active substance, the same size ...
    The preparation step is meticulous and requires concentration and gestural precision of the nursing staff during the manual placement of the pills in the pillbox housing.
    In particular, the preparation stage is all the more meticulous when the receptacles of a pill box are small and close to each other.
    When the conditions of concentration and gestural precision of the nursing staff are not met, it is possible that pills are not placed in the right accommodation. Indeed, it is possible that in case of fatigue and / or inattention of the nursing staff, the latter may inadvertently place a pill in the wrong place or be mistaken about the pill to be placed. In addition, it is possible that a pill may rebound, when placed, on a wall of a housing or on another pill, in a bad housing.
    However, incorrect placement of the pills in the pill box can lead to errors in administration, and therefore have negative consequences for the patient after dispensing. For example, the treatment may lose its therapeutic effectiveness or even lead to the development of side effects harmful to the patient.
    DE 102011086575 describes a filling method in which a pill box having a plurality of pill receiving receptacles is placed on a screen. A medicine is then placed in a container of a pill organizer to be prepared from filling data associated with a patient and then an image of the pill organizer is acquired. This image is then displayed on an area of the screen on which the pill organizer is not placed and is then stored in a database. These steps are repeated until all of the pillbox compartments are filled.
    The method described by DE 102011086575 makes it possible to monitor the filling of the pill box by archiving the images in a database. However, it does not avoid the aforementioned drawbacks.
    The invention aims to overcome these drawbacks.
    It aims in particular to propose a process for preparing a reliable pill organizer.
    The invention also aims to propose such a preparation process which is simple to implement.
    The invention also aims to propose a device for preparing a pill organizer adapted to implement such a process.
    The invention also aims to propose such a device which is inexpensive.
    To do this, the invention relates to a method for preparing a pill container comprising a plurality of receptacles for receiving at least one medicament, called pill, in a divided solid dosage form - at least not entirely pulverulent or even non-pulverulent -, process in which we carry out:
    a step, known as the initial step, in which the pillbox housings are placed opposite an image acquisition device,
    - At least two filling steps in which a set of at least one pill is placed in each filling step in at least one pillbox housing according to data, called filling data, of a medical prescription for a therapeutic treatment d 'a patient,
    - at least two steps of image acquisition of the pill organizer by the image acquisition device including:
    o a step of acquiring an image of the pill box after a filling step, o another step of acquiring an image of the pill box after another filling step, characterized in that after at least one in particular each acquisition step, known as the current acquisition step, a step, implemented by computer, of checking the filling of the pill box in which:
    o an image acquired during said current acquisition step is compared to an image acquired during an acquisition step preceding said current acquisition step so as to identify the pills placed between this acquisition step preceding said current acquisition step and the current acquisition step, o then compliance of the filling is evaluated on the basis of a comparison between the identified pills and the filling data.
    The invention extends to a device for preparing a pill container comprising a plurality of receptacles for receiving at least one medicament, called pill, in a divided solid dosage form - at least not entirely pulverulent or even non-pulverulent - device of preparation comprising an image acquisition device adapted for:
    - be placed opposite the pillbox housings during at least two filling steps in which, at each filling step, a set of at least one pill is placed in at least one pillbox housing according to data, called filling data , of a medical prescription for a therapeutic treatment of a patient,
    - carry out at least two image acquisitions of the pillbox by the image acquisition device including:
    o an acquisition of an image of the pill container after a filling step, o another acquisition of an image of the pill container after another filling step, characterized in that it comprises a data processing device comprising means for setting implemented, after at least one, in particular each, acquisition step, known as the current acquisition step, a step of controlling the filling of the pill box in which:
    o an image acquired during said current acquisition step is compared to an image acquired during an acquisition step preceding said current acquisition step so as to identify the pills placed between this acquisition step preceding said step d 'current acquisition and the current acquisition step, o then a conformity of the filling is evaluated from a comparison between the identified pills and the filling data.
    The invention also extends to a computer program comprising program code instructions for executing the steps of a method according to the invention when said program is executed on a computer.
    In particular, the computer program comprises program code instructions which, when the program is executed by a computer, cause the latter to implement a step of controlling a filling of a pill box comprising a plurality of receptacles for receiving at least one drug, known as a pill, in a divided solid dosage form, in which:
    an image comprising said pill box comprising a set, called first set, of at least one pill placed in at least one housing of the pill box is compared with an image comprising said pill box comprising said first set of at least one pill and a set, said second set, of at least one pill placed in at least one pillbox housing so as to identify each pill of said second set, o then a conformity of the filling is evaluated on the basis of a comparison between the identified pills and data, say fill data.
    The invention also extends to a computer-readable recording medium comprising program code instructions for carrying out the steps of a method according to the invention when they are executed on a computer.
    In particular, the computer-readable recording medium comprises program code instructions which, when executed by a computer, lead the latter to implement a step of controlling a filling of a pill box comprising a plurality of receptacles for receiving at least one drug, known as a pill, in a divided solid dosage form, in which:
    an image comprising said pill box comprising a set, called first set, of at least one pill placed in at least one housing of the pill box is compared with an image comprising said pill box comprising said first set of at least one pill and a set, said second set, of at least one pill placed in at least one pillbox housing so as to identify each pill of said second set, o then a conformity of the filling is evaluated on the basis of a comparison between the identified pills and data, say fill data.
    More particularly, the pill box to be filled can for example be a disposable pill box as described by FR 2913333. In particular, the pill box can for example be used for a daily or weekly medical prescription.
    The drugs to be placed during the preparation of the pill organizer can be chosen from the group formed in particular of tablets, cachets, capsules, capsules, pills, lozenges, dragees.
    Furthermore, preferably, the data processing device is a computer, that is to say a computer system, comprising at least one processor capable of performing at least the step of controlling a method according to the invention . The data processing device could also be a microprocessor, a server ...
    In particular, the data processing device includes input / output ports. In addition, the data processing device also includes a memory adapted to store digital data.
    The image acquisition device can be a photographic device, a camera, a scanner, in particular adapted to be used as a peripheral of said data processing device and connected to said data processing device.
    As used in the present text, the expression “computer-readable recording medium” can refer to any device which may contain, memorize, communicate, propagate or transport a program for its use by or in connection with a computer system, terminal, apparatus, or device for executing program code instructions. Such a computer-readable recording medium can be, by way of nonlimiting example, a terminal, a device, an apparatus, a system or an electronic, magnetic, optical, electromagnetic, infrared or semiconductor propagation medium. Some specific non-exhaustive examples of a computer-readable medium may be the following: a computer terminal, an electrical connection having one or more conductors, a mass memory (hard disk, USB key ...), a floppy disk, a memory with random access (RAM), a read-only memory (ROM), a read-only memory erasable by programming (EPROM or flash memory), an optical fiber, an optical read memory (compact disc read only or rewritable).
    In certain advantageous embodiments and according to the invention, during said step of controlling the filling of the pill box:
    the image acquired during said current acquisition step is compared with an image acquired during the acquisition step which chronologically precedes said current acquisition step so as to identify the pills placed between this acquisition step which chronologically precedes said current acquisition step and the current acquisition step, o then compliance of the filling is evaluated on the basis of a comparison between the identified pills and the filling data.
    Preferably, an acquisition step is carried out after each filling step.
    In addition, there is a step of checking the filling of the pill box after each acquisition step.
    In such embodiments, replacement of misplaced pills, identified following an evaluation of non-compliance of the filling, is simplified.
    However, in other embodiments, it is possible to carry out the image acquisition steps only after a certain number of filling steps between each of these image acquisition steps. A filling control step is then carried out after each image acquisition step by comparing the image acquired during this image acquisition step with that acquired during the previous acquisition step.
    In certain other embodiments, an image acquisition step is carried out after each filling step and a filling control step is carried out only after a certain number of image acquisition steps by comparing the image, called the last image, acquired during one of these image acquisition steps to that acquired during one of these acquisition steps and which precedes the step of acquiring said last image, several acquisition steps that may have taken place between these two acquisition steps.
    In certain other embodiments, the image acquisition steps are only carried out after a certain number of filling steps between each of these image acquisition steps and a filling control step is only carried out that after a certain number of image acquisition steps by comparing the image, called the last image, acquired during one of these image acquisition steps with that acquired during one of these steps d acquisition and which precedes the acquisition step of said last image, several acquisition steps having been able to take place between these two acquisition steps.
    In certain advantageous embodiments and according to the invention, a plurality of pills are placed in at least one pill box housing, all the pills placed in the same housing being identical.
    Thus, at the end of a preparation process according to the invention, the set of pills included in each container of the pill container comprising a plurality of pills comprises only identical pills (same dosage form, same dosage, same active substance, same cut...).
    Preferably, the pill container comprises a plurality of portions each comprising at least one housing - in particular a plurality of housings - each portion being intended to receive a unit intake of pills, that is to say a set of pills intended to be administered substantially in a single take to a patient at a given time, said set of pills being in accordance with the dosage of a medical prescription intended for the treatment of at least one pathology affecting this patient. The different housings of each portion are separated from each other so as to isolate from each other the different drugs from the same unitary intake of pills (as described by FR2913333).
    Preferably, said portions are detachable portions linked together by breakable links so as to be able to detach a portion for each unitary intake of pills.
    For each filling step, the filling data include information on the type of pill to be placed (including the name of the medication, the dosage or even the color and size of the pill), on the number of pills to be placed in the pill box and the housings (position, number) in which they are to be placed. These filling data are prerecorded in a memory of said data processing device and associated with a patient identifier.
    In particular, during the initial step, in particular a nursing staff indicates, to said data processing device the identifier of the patient for whom the pill container must be prepared so that said data processing device can retrieve from memory the filling data to be used during the pill dispenser preparation process.
    More particularly, advantageously and according to the invention, at each filling step, an indication, called filling indication, relating to the filling data for this filling step is displayed on a screen, called the filling help screen. Such a filling help screen is connected to said data processing device.
    In addition, in certain advantageous embodiments and according to the invention, there is the filling aid screen opposite the pillbox housings and opposite the image acquisition device with respect to the pillbox.
    More particularly, the filling aid screen is placed below the housings, that is to say opposite to access openings to the pill organizer housings.
    ίο
    Such a filling help screen is then adapted to indicate the housings in which at least one pill is to be placed by illuminating according to a predetermined color code regions of the screen placed below these housings. In addition, the number of pills to be placed in each of these slots can also be indicated on these areas of the screen.
    Such a filling help screen makes it easier to fill the pill box, which can be carried out in particular by nursing staff.
    In particular, in certain advantageous embodiments and according to the invention, in at least one filling step, a plurality of pills are placed in at least one pill box housing, the pills of said plurality of pills placed in the pill box during the same filling step being identical.
    Thus, we handle - in particular a nursing staff manipulates - only identical pills at each filling step. This not only reduces the risk of error in placing the pills, but also reduces the preparation time for the pill box.
    Furthermore, preferably, the pill organizer is fixed to a fixing support arranged so that the receptacles of the pill organizer are opposite the image acquisition device.
    The attachment of the pill organizer keeps the pill organizer in the same position relative to the image acquisition device which itself is fixed relative to the fixing support. Thus, the control step is facilitated.
    Furthermore, in certain advantageous embodiments and according to the invention, the initial step comprises a step of acquiring an image, called the initial image, of the pill box by the image acquisition device after having placed the pill box. next to the image acquisition device.
    Preferably, during this initial step, the pill box is empty of medication.
    However, in other embodiments, in particular when the same type of pill box is used for several methods of preparing a pill box, the initial image of the pill box is recorded in memory after a first acquisition of this initial image so as to be able to be reused for all of the pillbox preparation processes and avoid acquiring a new initial image for each of these processes.
    The image acquired during the first filling step following the initial step is compared to the initial image during the control step following this first filling step.
    In certain embodiments, when a filling step is completed, said data processing device is indicated by an input device connected to said data processing device that the filling step has been completed in order to be able to proceed to the acquisition stage and then the control stage.
    Alternatively, a balance can be placed under the pill box so as to detect the end of filling of a filling step as a function of the mass of the pill box and of a mass of the drugs indicated in the filling data so as to pass automatically at the acquisition stage then at the control stage.
    During each comparison step, digital data, in particular colorimetric data, representative of said image acquired during said current acquisition step, is compared in particular to digital data, in particular colorimetric data, representative of said image acquired during an acquisition step preceding said current acquisition step. This comparison makes it possible to identify, in digital data (in particular colorimetric data) produced during this comparison, the digital data representative of the pills placed between said acquisition step preceding said current acquisition step and the acquisition step. current.
    In particular, in order to compare said image acquired during said current acquisition step with said image acquired during an acquisition step preceding said current acquisition step, it is possible to make a difference between these two images ( in particular a difference in the colorimetric data of these two images) in order to obtain an image, called image to be analyzed, with which the pills placed during the previous filling step can be easily identified.
    In particular, at each control step the position of said identified pills is determined from image processing and analysis means and is compared to a position indicated by the filling data of the filling step preceding this step of control.
    For example, the position of the identified pills can be determined from the color data of said image to be analyzed. In addition, it is also possible to determine the position of the identified pills by detecting the contours of the identified pills (in particular from a black and white image obtained from said image to be analyzed or from the application of a filter Obey this image to be analyzed).
    In addition, at each control step, a quantity of said pills identified in each housing is determined from image processing and analysis means and compared with an amount indicated by the filling data of the preceding filling step. this control step.
    In particular, the quantity of pills in each housing can be determined from the position of the pills and the contours of said identified pills.
    In certain advantageous embodiments and according to the invention, at each control step, the image acquired during said current acquisition step is compared with the image acquired during the acquisition step preceding said step of current acquisition only in certain areas, called areas of interest, corresponding to the position of the pillbox housings whose spatial coordinates have been recorded.
    In addition, the processing and analysis means analyze only the image to be analyzed at the level of these areas of interest.
    In particular, the spatial coordinates are recorded in the memory of said data processing device from an image of a pill organizer acquired during a calibration step in which this pill organizer is placed, in particular fixed, opposite the recording device. image acquisition.
    After comparing said image acquired during said current acquisition step with said image acquired during an acquisition step preceding said current acquisition step, the conformity of the filling is evaluated.
    In particular, the compliance of the filling is assessed from a comparison between numerical data relating to the identified pills (in particular the position, quantity and type of the identified pills) and the filling data.
    The conformity assessment of the filling makes it possible to determine whether the pills placed during the filling step have been placed in the housings indicated by the filling data. It also makes it possible to determine if the number of pills placed in the housings corresponds to that indicated by the filling data. In addition, it also makes it possible to determine whether housings not indicated by the filling data include pills and also whether pills not indicated by the filling data are present in the filling housings indicated by the filling data.
    After evaluating the compliance of the filling, said data processing device is programmed to report compliance or not of the filling with respect to the filling data.
    In particular, preferably, at each control step, an indication of conformity of the filling of the pill container is displayed on at least one screen, called the control screen, after the conformity of the filling has been evaluated.
    As a variant or in combination, the indication of conformity of the filling of the pill box may be an audible signal.
    In a preferred embodiment and according to the invention, at each control step, an indication of conformity of the filling of each of the pillbox housings is displayed on at least one screen, called the control screen, after the conformity of the filling has been assessed.
    More particularly, this control screen can also be the filling aid screen (and can therefore be placed under the pillbox housings).
    In addition, the control screen displaying the indication of conformity of the filling of each of the pillbox receptacles can be the same as the control screen displaying the indication of conformity of the filling of the pillbox.
    In the event that the filling is assessed as non-compliant, the passage to a next filling step is prevented until the pills are placed according to the filling data.
    In particular, the accommodation that does not comply with the filling data is indicated on the control screen so that the pills that have to be moved to comply with the data can be identified quickly - in particular so that nursing staff can identify quickly. filling.
    In particular, the regions of the control screen placed opposite the housings which do not conform to the filling data can be colored according to a predetermined color code (in particular a red color) and the number of pills to be placed in these housings can be indicated there. also.
    Dwellings that comply with the filling data can also be indicated on the control screen.
    In particular, the regions of the control screen placed opposite the housings conforming to the filling data can be colored according to a predetermined color code (for example a green color).
    When the nursing staff has finished replacing the pills according to the filling data, a new step of acquiring an image of the pill organizer is carried out, then a new step of checking this image.
    In the event that the filling is assessed as compliant, the transition to a next filling step is authorized.
    Dwellings that comply with the filling data can also be indicated on the control screen.
    In particular, the regions of the control screen placed next to the housings can be colored according to a predetermined color code (for example a green color).
    When all the filling steps of the preparation process have been carried out and the pillbox housings comply with all of the filling data, the housings are covered with a seal to seal the pillbox.
    A method according to the invention makes it possible to assess the conformity of the filling after each filling step.
    A method according to the invention therefore makes it possible to determine after each filling step if an error in the filling of the pill container has occurred.
    A method according to the invention therefore makes it possible to assist a nursing staff during the preparation of a pill organizer by checking the conformity of the filling of the receptacles of the pill organizer.
    In addition, a method according to the invention makes it possible, by checking the conformity of the filling after each filling step, to facilitate the correction of the filling (if it does not comply with the filling data) compared to a method for preparing a filling. '' a pill box in which a single filling check would be carried out when all the pills to be placed are placed in the pill box slots.
    A method according to the invention is simple and easy to implement.
    In addition, a device for preparing a pill container according to the invention is inexpensive.
    The invention also relates to a method for preparing a pill box, a device for preparing a pill box, a computer program and a computer-readable recording medium characterized in combination by all or some of the characteristics mentioned above. or below.
    Other objects, characteristics and advantages of the invention will appear on reading the following description given without limitation and which refers to the appended figures in which:
    FIG. 1 is a diagram of a device for preparing a pill container according to one embodiment of the invention,
    FIG. 2 is a sequential diagram of a process for preparing a pill organizer according to an embodiment of the invention,
    - Figure 3 is a diagram of a pill box on which are represented areas, called areas of interest.
    A device 20, shown in FIG. 1, for preparing a pill box 23 according to the invention comprises a support 21 for fixing a pill box 23.
    The fixing support 21 comprises lugs 22 for fixing pill organizers 23 adapted to be placed in abutment with a pill organizer 23 to fix said pill organizer 23.
    More particularly, the pill box 23 includes openings 42 for receiving the pins 22 for fixing on at least one edge of the pill box 23.
    The fixing support 21 can for example be that described by FR 2 942 132.
    The pill box 23 comprises a plurality of receptacles 40 for receiving at least one medicament, called pill 41, in a solid galenical form divided at least not entirely powdery (for example capsules) or even non-powdery (for example tablets).
    Preferably, the pill container 23 comprises a plurality of portions each comprising at least one housing 40 - in particular a plurality of housings 40 - intended to receive a unitary intake of pills, that is to say a set of pills intended to be administered substantially in a single take to a patient at a given time, said set of pills being in accordance with the dosage of a medical prescription intended for the treatment of at least one pathology affecting this patient.
    In addition, in each of said plurality of portions, the adjacent housings 40 included in this portion can be separated by a common wall, in particular a removable wall. Alternatively, the adjacent housings 40 included in a portion of said plurality of portions can be spaced from each other.
    Preferably, said portions are detachable and linked together by breakable links so as to be able to detach a portion for each unitary intake of pills.
    The support 21 for fixing makes it possible to position the housings 40 of the pill organizer 23 opposite a device 24 for acquiring images itself placed opposite the support 21 for fixing.
    The image acquisition device 24 is therefore designed and adapted to carry out image acquisitions of a pill box 23 placed opposite this image acquisition device 24, in particular above the pill box 23, it that is to say next to the access openings of the housings 40.
    The image acquisition device 24 is preferably rigidly fixed to the support 21 for fixing the pill box.
    The image acquisition device 24 can be a photographic camera, a camera, a scanner 28, in particular adapted to be used as a peripheral of said data processing device 25 and connected to said data processing device 25.
    The image acquisition device 24 is connected to a data processing device 25. This data processing device 25 can for example be a computer.
    The data processing device 25 comprises in particular image processing and analysis means. In addition, the data processing device 25 comprises in particular a memory.
    Said data processing device 25 also includes a computer program adapted to use said image processing and analysis means.
    In particular, this computer program is recorded on a computer-readable recording medium. Preferably, said recording medium is the memory of the data processing device 25.
    Said computer program is used during a method according to the invention for the preparation of a pill box 23, in particular during steps of filling the pill box 23, of acquisition of images of the pill box 23 and of checking the filling of the pill box 23. pill box 23.
    In addition, the data processing device 25 is connected to a main screen 26 on which a graphical interface can be displayed from said computer program.
    A method for preparing a pill box 23, represented according to an embodiment of the invention in FIG. 2, comprises an initial step 30 in which an empty pill box 23 is placed and fixed, comprising a plurality of receptacles 40 for receiving at least one pill 41 on said support 21 for fixing so that the housings 40 of the pill box 23 are opposite the device 24 for acquiring images.
    Preferably, during this initial step 30, an image, called the initial image, of the empty pill organizer 23 is acquired by the image acquisition device 24 and transmitted to the data processing device 25 which stores it in memory.
    In addition, zones, called zones 43 of interest, shown as an example in FIG. 3, corresponding to the position of the housings 40 of the pill box 23 are defined during a calibration step (which may be included in the initial step 30 or precede it) and their spatial coordinates are recorded in memory of the data processing device 25.
    The acquisition of an image of the empty pill box 23 and a definition of areas of interest 43 can be carried out as soon as a process for preparing a pill box 23 according to the invention is carried out. As a variant, it is possible to carry out a single acquisition of an image of an empty pill box 23 and a single definition of areas 43 of interest for several methods according to the invention for preparation when the pill boxes 23 to be prepared during these processes are identical.
    A method for preparing a pill organizer 23 also includes a step 31 of loading data d L. n , called filling data, (n being equal to the number of filling steps described below of the filling preparation method) by the data processing device 25 in which a patient is selected from a database stored in memory of the device 25 of data processing according to a given patient's ID, then the device 25 data processing system extracts the data E n filling stored in memory device 25 processing and related to a given identifier of the patient.
    The filling data d L , n relate to a medical prescription of the patient to which they are linked. The filling data d Ln therefore include indications on a dosage of the prescription and therefore indications on the filling of pill organizer 23 to be prepared for distribution to the patient. In particular, the data E n of filling comprises indications regarding the position of pills 41 to be placed in the housing 40 of the tablet container 23, the amount of each pill 41 in each housing 40 of the tablet container 23 and the type of each of these pills 41.
    A method according to the invention comprises at least two steps 32 of filling the pill organizer 23 after step 31 of loading the data d L , n of filling.
    In addition, the filling data d E n are divided into filling data d, i being between 1 and n, relating to a filling step i of a process for preparing a pill organizer 23 according to the invention.
    Thus, at each filling step i, a set of at least one pill 41 is placed in at least one housing 40 of the pill box 23 according to an arrangement indicated by the filling data di which relate to this filling step.
    Before being placed in the receptacles 40 of the pill organizer 23, the pills 41 are packaged in pill boxes 41, each box comprising a set of pills 41 identical to each other (same dosage form, same dosage, same substance active, same size ...).
    Each box of pills 41 advantageously has a barcode.
    Preferably, the pills 41 to be placed during a filling step are identical to one another (same dosage form, same dosage, same active substance, same size ...).
    Thus, only 41 identical pills are handled at each filling step. This not only reduces the risk of misplacement of the pills 41 but also reduces the preparation time of the pill box 23.
    In addition, before placing the pills 41 in at least one housing 40 of the pill box 23 at each filling step, it is preferable to read, using a scanner 28 of the preparation device 20, the barcode of the box comprising the pills 41 to be placed during this filling step.
    Reading the bar code makes it possible to indicate to the data processing device 25 which is connected to the scanner 28 the pills 41 which will be placed during the filling step.
    Preferably, at each filling step, each housing 40 in which at least one pill 41 must be placed during a filling step is indicated by a filling indication on a screen 27 for filling assistance placed opposite the housings 40 of the pill box 23 below the pill box 23, and therefore opposite the acquisition device 24 relative to the pill box 23.
    More particularly, regions of the filling aid screen 27 placed opposite the housings 40 in which at least one pill 41 is to be placed are illuminated according to a predetermined color code. In addition, for each of these regions of the filling aid screen 27, a number can be displayed on this region so as to indicate the number of pills 41 to be placed in the housing 40 opposite this region.
    In the embodiment shown in FIG. 2, a method according to the invention comprises, after each step i of filling, a step i of acquisition (step 33 in FIG. 2) of an image of the pill organizer 23 by the device 24 image acquisition.
    In particular, when a filling step i is completed, said data processing device 25 is indicated by an input device 29 connected to said data processing device 25 that the filling step i has been completed in order to be able to go to step i of acquisition.
    As a variant, a balance can be placed under the pill box 23 so as to detect the end of filling of a filling step i as a function of the mass of the pill box 23 and of a mass of the drugs indicated in the filling data so to automatically go to acquisition step i.
    In the embodiment shown in FIG. 2, a method according to the invention comprises, after each acquisition step i, a step 34 for checking the filling of the pill container 23.
    In particular, step 34 of checking the filling of the pill box 23 includes a step 35 of comparing the image /, acquired during the acquisition step i with respect to the image acquired during the step i- 1 acquisition, i being between 1 and n, I o being the initial image and the acquisition step 0 being the initial step 30.
    The acquisition step i-1 is therefore the acquisition step which chronologically precedes the acquisition step i in all of the acquisition steps of the pill organizer preparation process 23.
    In image Z, ·.;, The pill box 23 comprises a set, called the first set, of at least one pill 41, if i is greater than 1 (no pill 41 for the image I o on which the pill box 23 is empty). This first set includes the pills 41 placed during the filling step i-1 which precedes the acquisition step i-1 and the pills 41 placed before this filling step i-1.
    In image f, the pill box 23 comprises the first set of at least one pill 41 and a second set of pills 41 comprising the pills 41 placed during the filling step i which precedes the acquisition step i
    The computer program is programmed to compare the image /, with respect to the image Z, · .; so as to identify each pill 41 of said second set of pills 41, and therefore each pill 41 having been placed in the pill box 23 during the filling step i.
    In particular, during the comparison step 35, the data processing device 25 uses a computer program to make a difference between the image /, and the image Z, · .; (in particular a difference in the color data of these two images) so as to identify each pill 41 of said second set of pills 41. The difference between the image /, and the image Z, · .; makes it possible to obtain an image, called image to be analyzed, on which only the pills 41 placed during filling step i are present so that they can be easily identified during an analysis step 36.
    When each pill 41 of said second set of at least one pill 41 has been identified, the processing device 25 determines, using said computer program, the position of each pill 41 of this second set.
    The position of the pills 41 is determined using means, in particular algorithms, of processing and analysis of images programmed in the computer program.
    For example, the position of the pills 41 can be determined from the color data of the image to be analyzed. In addition, it is also possible to determine the position of the pills 41 identified by identifying the contours of the pills 41 present on the image to be analyzed (in particular from a black and white image resulting from the image to be analyzed or even to from the application of a Sobel filter on the image to be analyzed).
    In addition, when each pill 41 of said second set of at least one pill 41 has been identified, the treatment device 25 also determines an amount of said pills 41 identified in each housing 40 of the pill box 23 by means of said computer program the position of each pill 41 of this second set.
    Said quantity of pills 41 identified can also be determined by means, in particular of algorithms, of processing and analysis of images programmed in the computer program.
    In particular, the quantity of pills 41 in each housing 40 can be determined from the position of the pills 41 and the contours of said pills 41 identified.
    In addition, the treatment device 25 can also determine by means of said computer program the type (in particular the name of the medicament) of each pill 41 of this second set.
    The type of each pill 41 of said second set can be determined using means, in particular algorithms, of processing and analysis of images programmed in the computer program.
    In particular, the type of each pill 41 of said second set can be determined from a colorimetric analysis of the image to be analyzed.
    Preferably, the analysis of the position, the quantity and the type of each pill 41 of said second set is carried out only at the level of said areas 43 of interest so as to reduce the number of calculations to be performed by the treatment device 25 of data.
    The determined position of each pill 41, the determined quantity of each pill 41 in each housing 40 and the determined type of each pill 41 are then compared in a step 37 with the position of each pill 41, the quantity of each pill 41 in each housing 40 and the type of each pill 41 indicated by t of filling data.
    More particularly, the processing and analysis of the image to be analyzed with respect to the filling data makes it possible to determine whether the pills 41 placed during the filling step i have been placed in the housings 40 indicated by the data d t filling. This treatment and this analysis also makes it possible to determine whether the number of pills 41 placed in the housings 40 corresponds to that indicated by the filling data d t . Moreover, they also allow to determine whether the housing 40 not shown by filling the di data include pills 41 and also if pills 41 not shown by the data of t filling are present in the housing 40 of filling indicated by the filling data.
    After evaluating the compliance of the filling carried out during the filling step i, the computer program is programmed to report compliance or not of this filling.
    In particular, the filling aid screen 27 is used so as to indicate the conformity or not of filling during a step 38 when the filling during a filling step of the pill container 23 is evaluated as conforming and during a step 39 when the filling during a filling step of the pill box 23 is evaluated as non-compliant.
    In the case where the filling carried out during the filling step i is evaluated as non-compliant, the passage to a next filling step i + 1 is prevented (by displaying for example a message of nonconformity of the filling in a modal window on main screen 26) until the pills 41 are placed according to the filling data d.
    In particular, the housings 40 that do not comply with the filling data d are indicated during step 39 by indications of conformity of the filling on the screen 27 for filling assistance so that the pills 41 that can be quickly identified are 'it must move to comply with the filling data.
    In particular, the regions of the filling aid screen 27 placed opposite the housings 40 that do not conform to the filling data can be colored according to a predetermined color code (in particular a red color) and the number of pills 41 to be placed in these housings 40 can also be indicated.
    The housings 40 conforming to the filling data can also be indicated during step 39 by other filling indications on the filling aid screen 27.
    In particular, the regions of the filling aid screen 27 placed opposite the housings 40 conforming to the filling data di can be colored according to a predetermined color code (for example a green color).
    When the pills 41 have been replaced according to the filling data, a new step i of acquiring an image i, of the pill box 23 is carried out, then a new step 34 of checking the filling in which the l is always compared. image to image ή · _ 7 of step i-1 of acquisition in which the pill box 23 comprises only said first set of at least one pill 41.
    In the case where the filling is evaluated as conforming, the passage to a next filling step according to data d i + 1 of filling is authorized by the computer program.
    The housings 40 conforming to the filling data d t can also be indicated during step 38 by indications of conformity of the filling on the screen 27 for assistance with filling.
    In particular, the regions of the filling aid screen 27 placed opposite the housings 40 can be colored according to a predetermined color code (for example a green color).
    When all the filling steps of the preparation process have been carried out and the housings 40 of the pill organizer 23 comply with all of the filling data, the housings 40 are covered with a seal to seal the pill organizer 23.
    The invention therefore relates to a method for preparing a pill box 23, a device 20 for preparing a pill box 23, a computer program and a computer-readable recording medium for placing pills 41 in a pill box 23. according to a patient's medical prescription reliably and inexpensively.
    A method according to the invention for preparing a pill organizer 23 can be carried out by nursing staff.
    The invention can be the subject of numerous variant embodiments with respect to the embodiments described above and represented in the figures. In particular, the initial step 30 and the filling steps 32 can be carried out by a machine. In addition, the control step 34 may not be carried out after each acquisition step.
    权利要求:
    Claims (15)
    [1" id="c-fr-0001]
    1 / - Process for the preparation of a pill organizer (23) comprising a plurality of housings (40) for receiving at least one medicament, called pill (41), in a divided solid dosage form, process in which:
    a step, called the initial step (30), in which the housings (40) of the pill box (23) are placed opposite a device (24) for acquiring images,
    - At least two filling steps in which, at each filling step, a set of at least one pill (41) is placed in at least one housing (40) of the pill box (23) according to data, called filling data, d '' a medical prescription for a therapeutic treatment of a patient,
    - at least two steps (35) of image acquisition of the pill box (23) by the device (24) of image acquisition including:
    o a step of acquiring an image of the pill box (23) after a filling step, o another step of acquiring an image of the pill box (23) after another filling step, characterized in that performs, after at least one acquisition step, called the current acquisition step, a step (34), implemented by computer, of checking the filling of the pill box (23) in which:
    o an image acquired during said current acquisition step is compared to an image acquired during an acquisition step preceding said current acquisition step so as to identify the pills (41) placed between this acquisition step preceding said current acquisition step and the current acquisition step, o then compliance of the filling is evaluated on the basis of a comparison between the pills (41) identified and the filling data.
    [2" id="c-fr-0002]
    2 / - Method according to claim 1 characterized in that during said step (34) of checking the filling of the pill box:
    the image acquired during said current acquisition step is compared to an image acquired during an acquisition step preceding said current acquisition step so as to identify the pills (41) placed between this acquisition step preceding said current acquisition step and the current acquisition step, o then a conformity of the filling is evaluated on the basis of a comparison between the pills (41) identified and the filling data.
    [3" id="c-fr-0003]
    3 / - Method according to any one of claims 1 or 2 characterized in that a step of image acquisition is carried out after each filling step.
    [4" id="c-fr-0004]
    4 / - Method according to one of claims 1 to 3 characterized in that there is carried out a step of controlling the filling of the pill box after each image acquisition step of the pill box (23).
    [5" id="c-fr-0005]
    5 / - Method according to one of claims 1 to 4 characterized in that a plurality of pills (41) are placed in at least one housing (40) of the pill box (23), and in that all the pills placed in the same accommodation are identical.
    [6" id="c-fr-0006]
    6 / - Method according to one of claims 1 to 5 characterized in that in at least one filling step is placed a plurality of pills (41) in at least one housing (40) of the pill box (23), and in that that the pills of said plurality of pills (41) placed in the pill box during the same filling step are identical.
    [7" id="c-fr-0007]
    7 / - Method according to one of claims 1 to 6 characterized in that the initial step (30) comprises a step of acquiring an image, called the initial image, of the pill box (23) by the device (24) image acquisition after placing the pill box (23) opposite the image acquisition device (24).
    [8" id="c-fr-0008]
    8 / - Method according to one of claims 1 to 7 characterized in that at each step (34) of control the position of said pills (41) identified is determined from image processing and analysis means and is compared with a position indicated by the filling data of the filling step preceding this checking step (34).
    [9" id="c-fr-0009]
    9 / - Method according to one of claims 1 to 8 characterized in that at each control step (34), a quantity of said pills (41) identified in each housing (40) is determined from processing means and image analysis and compared with an amount indicated by the filling data of the filling step preceding this step (34) of control.
    [10" id="c-fr-0010]
    10 / - Method according to one of claims 1 to 9 characterized in that at each control step (34), the image acquired during said current acquisition step is compared to the image acquired during acquisition step preceding said current acquisition step only on certain zones, called zones (43) of interest, corresponding to the position of the housings (40) of the pill box (23) whose spatial coordinates have been recorded.
    [11" id="c-fr-0011]
    11 / - Method according to one of claims 1 to 10 characterized in that at each control step (34), an indication of conformity of the filling of each of the housings (40) of the pill box (23) is displayed on at least one screen , says control screen, after the conformity of the filling has been evaluated.
    [12" id="c-fr-0012]
    12 / - Method according to one of claims 1 to 11 characterized in that at each filling step, an indication, called filling indication, relating to the filling data for this filling step is displayed on a screen, said screen (27) filling aid.
    [13" id="c-fr-0013]
    13 / - Device for preparing a pill container (23) comprising a plurality of housings (40) for receiving at least one medicament, known as a pill (41), in a divided solid dosage form, preparation device comprising a device ( 24) image acquisition suitable for:
    - be placed opposite the housings (40) of the pill box (23) during at least two filling steps in which, at each filling step, a set of at least one pill (41) is placed in at least one housing ( 40) of the pill box (23) according to data, called filling data, of a medical prescription for a therapeutic treatment of a patient,
    - carry out at least two image acquisitions of the pill box (23) by the image acquisition device (24) including:
    o an acquisition of an image of the pill box (23) after a filling step, o another acquisition of an image of the pill box (23) after another filling step, characterized in that it comprises a device (25) data processing comprising means for implementing, after at least one acquisition step, known as the current acquisition step, a step (34) for checking the filling of the pill box (23) in which:
    o an image acquired during said current acquisition step is compared with an image acquired during an acquisition step preceding said current acquisition step so as to identify the pills (41) placed between this acquisition step preceding said current acquisition step and the current acquisition step, then compliance of the filling is evaluated on the basis of a comparison between the pills (41) identified and the filling data.
    [14" id="c-fr-0014]
    14 / - Computer program comprising program code instructions for the execution of the steps of a method according to one of claims 1 to 12 when said program is executed on a computer.
    [15" id="c-fr-0015]
    15 / - A computer-readable recording medium comprising program code instructions for the execution of the steps of a method according to one of claims 1 to 12 when they are executed on a computer.
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    同族专利:
    公开号 | 公开日
    EP3593353A1|2020-01-15|
    FR3063716B1|2021-04-30|
    CA3052724A1|2018-09-13|
    WO2018162168A1|2018-09-13|
    US20200027212A1|2020-01-23|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    WO2002025568A2|2000-09-22|2002-03-28|Sound Vision, Inc.|Pill identification and prescription management device, system and method|
    DE102011086575A1|2011-11-17|2013-05-23|Martin Halm|Device for individual filling of blisters, has computer and monitor, where monitor is connected with computer, and filling tray for receiving cardboard blister is arranged on horizontally arranged monitor|
    WO2015113167A1|2014-02-03|2015-08-06|Synergy Medical Brg Inc.|System for assisting the preparation of medication dose packs and methods|WO2021191550A1|2020-03-25|2021-09-30|Distraimed|Device and method for preparing a pill organiser and for checking said preparation|DE10128324A1|2001-06-12|2003-01-09|Matsushita Electric Works Europe Ag|Device for optically checking the contents of blister packs|
    FR2913333A1|2007-03-05|2008-09-12|Olivier Michel Albert Lucien Foubet|Disposable pillbox for distributing capsule type medication in healthcare facility, has cells each including eight compartments and covered by adhesive label that is adhered on circumference of cell and on walls of each compartment|
    FR2942132B1|2009-02-13|2011-03-25|Olivier Michel Albert Lucien Foubet|FILLING SYSTEM OF PILLARS|US10892048B2|2017-09-28|2021-01-12|Puli Pravin Reddy|Machine learning pill identification|
    FR3095338A1|2019-04-25|2020-10-30|Medissimo|Device for filling a pill container and associated method.|
    法律状态:
    2018-03-20| PLFP| Fee payment|Year of fee payment: 2 |
    2018-09-14| PLSC| Search report ready|Effective date: 20180914 |
    2020-03-19| PLFP| Fee payment|Year of fee payment: 4 |
    2021-03-23| PLFP| Fee payment|Year of fee payment: 5 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1751996A|FR3063716B1|2017-03-10|2017-03-10|METHOD AND DEVICE FOR PREPARING A PILL BOX|
    FR1751996|2017-03-10|FR1751996A| FR3063716B1|2017-03-10|2017-03-10|METHOD AND DEVICE FOR PREPARING A PILL BOX|
    US16/491,402| US20200027212A1|2017-03-10|2018-02-08|Method and device for producing a pill box|
    CA3052724A| CA3052724A1|2017-03-10|2018-02-08|Method and device for producing a pill box|
    EP18703598.5A| EP3593353A1|2017-03-10|2018-02-08|Method and device for producing a pill box|
    PCT/EP2018/053200| WO2018162168A1|2017-03-10|2018-02-08|Method and device for producing a pill box|
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