专利摘要:
The device (1) comprises: a first assembly (6) capable of cooperating with a handle subjected to control means for the actuation of the assembly for setting up and fixing an artificial rope (7) on the abutment (8) of a broken rope, said assembly is arranged at the end of a handling rod and comprises an elastic clip (9) pivotally and removably connected to the end of the rod so as to passing, under the action of the control means, a folded position along the rod to a position tilted angularly relative to the rod, to be placed perpendicularly to the pillar where the rope must be replaced, the first set ( 6) comprises means for opening the clip (9) for, under the action of the control means, anchoring the abutment (8) of the broken rope, the first set (6) comprises unlocking means allowing, under the action of the control means, to release the clip (9), the said clip afe (9) being connected to an artificial rope (7) which goes up in the stem; - A second assembly (13) adapted to cooperate with a handle subject to control means for actuating the assembly for the establishment and fixing of the artificial rope (7) to a leaflet (2a) of the valve (2), the second assembly (13) is arranged at the end of a handling rod and comprises fastening means (9, 16) for sliding along the artificial rope (7) and pivotally connected to the end of the rod so as to pass, under the action of the control means, a folded position along the rod at a position tilted orthogonally to the rod, the fastening means (9, 16) being suitable under the action of the control means, to fix the artificial rope (7) to said sheet (2a).
公开号:FR3063631A1
申请号:FR1752019
申请日:2017-03-13
公开日:2018-09-14
发明作者:Marco Vola;Bernard Pain
申请人:Cminov;
IPC主号:
专利说明:

TECHNICAL AREA
The invention relates to a device for repairing the cords of the mitral valve of a heart, in particular by transfemoral route, for example in the case of mitral prolapse.
PRIOR STATE OF THE ART
The treatment of mitral prolapse, linked in particular to the elongation or rupture of one or more ropes connecting the mitral valve to the papillary muscles of the heart, is a long and cumbersome operation that requires the opening of the cardiac chambers, the cage chest and extracorporeal blood circulation. The operation consists in particular of replacing the defective cord, that is to say of hanging an artificial cord between a sheet of the mitral valve and the pillars of the mitral valve apparatus or the apical part of the heart.
A known solution of the state of the art consists in using devices which can implant artificial ropes on the edges of the balancing valves by the transapical route, that is to say using a device intended to be positioned in a sealed introducer arranged into the thoracic cavity between two ribs to enter the left ventricle through the apex of the heart.
This device can be further improved, in particular by avoiding piercing the cardiac apex and by reducing the invasiveness of the surgical operation performed with this type of device.
STATEMENT OF THE INVENTION
The invention is intended to remedy the drawbacks of the state of the art in a safe, simple, effective and rational manner.
The problem which the invention proposes to solve is to facilitate the operation of repairing the cords of the mitral valve of a heart, by transfemoral route and without puncturing the artery, but the femoral vein
To this end, a device has been developed for repairing the cords of the mitral valve of a heart by the transfemoral route, and intended to be positioned in a sealed introducer placed in a femoral vein to penetrate into the left atrium of the heart through the septum wall that separates the right and left atrium.
According to the invention, the device comprises:
a first assembly capable of cooperating with a handle subject to control means for actuating the assembly for the establishment and fixing of an artificial cord on the pillar of a broken or pathologically elongated cord, said assembly is arranged at the end of a handling rod and comprises an elastic clip pivotally and removably connected to the end of the rod so as to pass, under the action of the control means, from a folded position on along the rod in a position tilted angularly relative to the rod to be placed perpendicularly facing the pillar where the rope is to be replaced, the first assembly comprises means of opening the clip for, under the action of the means of command, staple the pillar of the broken cord, (either by simple compression of two pors with irregular surface, or by compression of the two jaws of the graphite which contain extremit s perforating the pillar, partially or transfixing it completely), the first set includes unlocking means allowing, under the action of the control means, to release the clip, said clip being connected to an artificial cord which rises in the rod ;
a second assembly capable of cooperating with a handle subject to control means for actuating the assembly for the establishment and fixing of the artificial cord to a sheet of the valve, the second assembly is arranged at the end of a handling rod and comprises fixing means intended to slide along the artificial rope and pivotally connected to the end of the rod so as to pass, under the action of the control means, from a position folded along the rod in an angularly tilted position relative to the rod to be placed parallel to the mitral sheet, the fixing means being able, under the action of the control means, to fix the artificial cord to said sheet.
In this way, and advantageously, the device according to the invention makes it possible, in combination with a handle and actuating means which are not part of the invention, to carry out the repair operation of a mitral valve cord by the transfemoral route up through the vena cava. The active sets of the device navigate in the vena cava where the blood pressure is relatively low.
According to a first embodiment, the fixing means comprise an opening, repositionable and removable elastic clip, means for opening the clip, and means for unlocking the clip similar to those of the first assembly. The clip of the second set is intended to be anchored on the sheet to fix the artificial rope
The artificial cord is, for example, in the form of a non-absorbable polyamide or teflon suture thread.
The artificial rope can be notched, and the clip of the second set includes means for sliding on the artificial rope notched only in the direction of the clip of the first set.
According to another embodiment, the clip of the second set comprises a wire intended to form a fixing loop around the artificial cord, the artificial cord being able to be tied around said loop.
Advantageously, the second assembly comprises a stabilizing clamp pivotally connected to the end of the rod so as to pass, under the action of the control means, from a folded position along the rod to a position tilted angularly at the rod to be parallel to the plane of the sheet, and from an open position to a closed position to pinch and stabilize the sheet for stapling.
According to another particular embodiment, the fixing means comprise a clamp pivotally connected to the end of the rod so as to pass, under the action of the control means, from a folded position along the rod at a position tilted angularly to the rod to be parallel to the plane of the sheet fabric, and from an open position to a closed position to pinch the sheet. The second set includes a movable needle for coming, under the action of the control means, to pierce the sheet through an opening presented by the clamp and fix the artificial cord to the sheet.
Preferably, the needle internally comprises a shape memory suture capable of being extracted to form a loop to fix the artificial cord to the sheet.
According to another particular embodiment, the needle comprises means for gripping the artificial cord after piercing the sheet.
According to a particular embodiment, the clip comprises two elastic branches close to one another with hooked end portions. The opening / unlocking means comprise two arms arranged between the elastic branches of the clip and articulated around a pivot so as to pass, under the action of the control means, from a close position one of the 'other to a position apart by forcing the spacing of the branches of the clip to cause its opening. The two arms are retractable to allow the release of the removable clip.
Preferably, the clamp comprises an upper jaw and a lower jaw, perforated for the passage of the needle. The lower jaw comprises a valve intended to adopt a closed position to hold the artificial cord, while allowing the clamp to slide around and along said artificial cord, and an open position for releasing the artificial cord.
Preferably, and to facilitate the surgical operation, the clip and the fixing means are radiopaque or else each comprise one or more radiopaque and / or ultrasound marker. They can also incorporate magnets to facilitate navigation under the presence of a specifically generated magnetic field.
Advantageously, and to facilitate the rehabilitation of human tissues, the staple (s) are sheathed in textile.
BRIEF DESCRIPTION OF THE DRAWINGS
Other characteristics and advantages of the invention will emerge clearly from the description which is produced below, by way of indication and in no way limiting, with reference to the appended schematic figures in which:
- Figure 1 illustrates a heart and the introduction, into the left atrium of the heart and through the mitral valve, of the manipulation rod of a first set that includes the device according to the invention;
- Figure 2 illustrates is a view similar to that of Figure 1, the head of the rod being retracted to reveal an elastic clip in the folded position;
- Figure 3 is a view similar to that of Figure 2, the clip being tilted into a position orthogonal to the rod;
- Figure 4 is a view similar to that of Figure 3, the clip having come to anchor on the pillar of the broken rope to be repaired;
- Figure 5 is a view similar to that of Figure 4, the rod of the first set having been removed so as to leave an artificial cord connected to the clip;
- Figure 6 is a detail view of the end of the rod of the first assembly according to the invention, with the retracted head and the clip in the folded position;
- Figure 7 is a view similar to that of Figure 6, with the clip tilted into a position orthogonal to the rod, and in the closed position;
- Figure 8 is a view similar to that of Figure 7, the clip being shown in the open position;
- Figure 9 is a detail view illustrating in perspective the clip used for anchoring to the pillar of the rope;
- Figure 10 is a view similar to that of Figure 9, the clip being shown in the open position;
- Figure 11 is a representation of a first embodiment for attaching the artificial cord to the sheet of the mitral valve, and illustrating the manipulation rod of a second assembly having passed through the mitral valve, the head of the rod having been retracted to reveal a second clip in the folded position along the rod;
- Figure 12 is a view similar to that of Figure 11, the clip having been tilted into a position orthogonal to the rod, the clip having slid along the artificial cord;
- Figure 13 illustrates the anchoring of the clip to the leaflet of the mitral valve, and the release of said clip, which is connected to the artificial cord;
- Figure 14 is a view similar to that of Figure 13, the cord having been knotted around a loop that includes the second clip, the cord replacement operation being completed;
- Figure 15 is a view illustrating in perspective the end of the handling rod of the second set, with the clip in the tilted and open position;
- Figure 16 is a schematic representation of a second embodiment, comprising an end rod of a second assembly having passed through the mitral valve of the heart, and illustrating a clamp tilted in angular position relative to the rod and having slid along the artificial rope connected to the first clip;
- Figure 17 is a view similar to that of Figure 16, the forceps having pinched the leaflet of the mitral valve;
- Figure 18 is a view similar to that of Figure 17, a suture having been released to form a loop for fixing the artificial cord to the sheet;
- Figure 19 is a view similar to that of Figure 18, the manipulation rod of the second set being shown in the process of withdrawing;
FIG. 20 is a view similar to that of FIG. 19, illustrating the artificial cord fixed to the pillar of the cord and to the leaflet of the valve by means of the suture, before the step consisting in knotting and tensioning said artificial rope to complete the operation;
- Figure 21 is a schematic perspective representation of the clamp of the second set according to the second embodiment, intended to attach the artificial cord to the leaflet of the valve;
- Figure 22 is a schematic representation of the manipulation rod of the second set according to the second embodiment, the clamp being shown in the folded position along the rod;
- Figure 23 is a view similar to that of Figure 22, the clamp having been tilted angularly relative to the rod and shown in the open position, in particular with the lower jaw of the clamp positioned under the sheet of the mitral valve;
- Figure 24 is a schematic representation similar to that of Figure 23, the clamp being shown in the closed position and in the pinching position of the valve sheet;
- Figure 25 is a view similar to that of Figure 24, a needle having been moved to pierce the leaflet of the mitral valve;
- Figure 26 is a view similar to that of Figure 25, a suture having been extracted to form a loop around the artificial cord and through the sheet;
- Figure 27 is a view similar to that of Figure 26, the needle having been withdrawn and the artificial cord having been released by the clamp;
- Figure 28 is a view similar to that of Figure 27, the manipulation rod of the second set having been removed, and the artificial cord being fixed to the sheet via the shape memory suture.
DETAILED PRESENTATION OF THE INVENTION
The invention relates to a device (1) for performing a surgical operation consisting in repairing broken or elongated cords of a mitral valve (2), for example in the case of a mitral prolapse.
The device (1) is intended to be positioned in a sealed introducer of any known and appropriate type (not shown) and with a diameter less than or equal to 12 mm, placed in a femoral vein to ascend and penetrate the left atrium (3) a heart (4) passing through its septal wall.
Referring to Figures 1 to 8, the device (1) comprises a first handling rod (5), at the end of which is arranged a first assembly (6) for the establishment and fixing of an artificial rope (7) on the pillar (8) of a broken rope. The other end of the first rod (5) is intended to cooperate with a handle subject to control means, not shown, for example in the form of a trigger for the actuation of the first assembly (6). The device (1) according to the invention allows, under ultrasound control and possibly also radiography, after having ascended the vena cava, to penetrate the first set (6) into the left atrium (3) of the heart (4) while passing through the septal wall. Then, when the first set (6) is in the left atrium (3) of the heart (4), it is able to pass through the mitral valve (2) to come opposite the pillar (8) of the cord broken (see Figure 2). The carrying catheter can be temporarily stiffened with the ideal curvature to work opposite the plane of the mitral valve.
The head of the first rod (5), constituted for example by an atraumatic warhead, is retractable to reveal internally an elastic clip (9) pivotally and removably connected to the end of the rod (5). The elastic clip (9), secured to the handle control means, is capable of passing, under the action of said control means, from a folded position along the rod (see FIGS. 2 and 6) to a tilted orthogonally position (see Figures 3, 4, 7, 8). To this end, the elastic clip (9) is received in a base (10), itself pivotally mounted about an axis (11), under the actuation of the control means. These control means, not shown, for example include sets of cables, connected to a part of the base (10), opposite to the clip (9), to pull or press on this rear part and to pivot the base (10) around its axis (11).
With reference to FIGS. 9 and 10, the clip (9) comprises two elastic branches (9a), brought together, with hooked end portions (9b) for anchoring as such . Referring to Figures 6 to 8, the clip (9) is held in the base (10) by means of two arms (12) disposed between the elastic arms (9a) of the clip (9), and articulated around a pivot, in particular around the axis (11) so as to pass, under the action of the control means, from a position close to one another (cf. FIGS. 6, 7, 15 ) in a separated position by forcing the spacing of the branches (9a) of the clip (9) to cause it to open. The pivoting of the arms (12) is carried out by the pivoting of the base (10).
The attachment of the clip (9) to the pillar (8) of the broken cord (see FIG. 4) makes it possible to maintain a sufficient distance between the elastic branches (9a) of the clip (9), creating a play by relative to the arms (12) which constitute means for opening and unlocking the clip (9), allowing said arms (12) to retract and release the removable clip (9) (cf. FIG. 5) .
Referring to Figure 5, the artificial cord (7) is knotted to the clip (9) and goes back inside the first rod (5) so that after removal of said rod, the artificial cord (7 ) goes up along the femoral vein.
Referring to Figures 12 to 28, the device (1) according to the invention also comprises a second assembly (13) able to cooperate with a handle, which can be the same handle as that of the first assembly (6), subject to control means for actuating this second assembly (13) for the establishment and fixing of the artificial cord (7) to a sheet (2a) of the valve (2).
In the same way as for the first set (6), the second set (13) is intended to go up the vena cava, and to penetrate into the left auricle (3) of the heart (4) while passing through the wall septal, in particular by following and sliding along the artificial cord (7) already present.
The second assembly (13) is arranged at the end of a second handling rod (14) and comprises fixing means (9, 16), pivotally connected to the end of the rod so as to pass, under the action of the control means, from a folded position ίο along the rod (14) (see Figure 11) to a tilted position (see Figures 12, 15 to 18, 21 and 23 to 27) to fix the artificial cord (7) to the sheet (2a) of the valve (2).
From this concept, several embodiments of the invention have been imagined.
According to a first embodiment, in particular illustrated in FIGS. 11 to 15, the means for fixing the artificial cord (7) to the sheet (2a) are in the form of a staple (9), similar to that of the first set ( 6), and which is intended to be anchored on the pillar (8) of the broken rope. In the same way, this second clip (9) is received in a base (10) pivotally mounted about an axis (11) to pass from a folded position along the second rod (14) (Cf. figure 11 ) in an angularly tilted position (see FIG. 12, 15) in order to be anchored on the sheet (2a) of the mitral valve (2). Arms (12) are arranged between the elastic branches (9a) of this second clip (9), to form unlocking locking means, in the same way as with the first clip (9). The second clip (9) is therefore designed to open and come to anchor on the sheet (2a). When the clip (9) is anchored on the sheet (2a), the arms (12) can be retracted to release said clip (9).
The second clip (9) is connected to the artificial cord (7). To do this, and with reference to FIGS. 13 and 14, the second clip (9) comprises, for example, a wire (15) which forms a loop around the artificial cord (7). This loop allows in particular said second clip (9) and the second assembly (13) to slide along the artificial cord (7). In this configuration, the artificial rope (7) can be tied around the loop and stretched to complete the rope repair operation. The artificial cord (7) is therefore fixed to the pillar (8) and the sheet (2a) by means of clips (9).
According to a second example not illustrated, the artificial cord (7), which is for example in the form of a nonabsorbable polyamide or teflon suture, can be notched. In this configuration, the clip (9) of the second set (13) can comprise any suitable means, such as a rack, for sliding along said artificial rope (7) notched and only in the direction of the clip (9) of the first set (6). In other words, when the second clip (9) is anchored on the sheet (2a), the tension of the artificial cord (7) is adjusted by sliding the second clip (9) along the notched artificial cord (7) .
The anchoring of the second clip (9) on the sheet (2a) of the valve (2) can be facilitated by means of a stabilizing clamp, not shown, similar to the clamp (16) which will be described below. . For this purpose the second assembly (13) comprises such a clamp pivotally connected to the end of the second rod (14) so as to pass, under the action of the control means, from a folded position along the rod (14) in a position regularly tilted to the rod (14), that is to say parallel to the sheet (2a) of the valve (2), and from an open position to a closed position for pinching and stabilize the sheet (2a) for anchoring the second elastic clip (9).
The fixing of the artificial cord (7) to the sheet (2a) of the valve (2) can be carried out in a different way. Indeed, with reference to FIGS. 16 to 28, instead of a second clip (9), the means for fixing the second assembly (13) may comprise a clamp (16) pivotally connected to the end of the second rod (14) so as to pass, under the action of the control means, from a folded position along the rod (14) (cf. FIG. 22) to an angularly tilted position (cf. FIGS. 16 to 18, 21 and 23 to 27), in particular parallel to the sheet (2a) of the valve (2). This clamp (16) is designed to pass from an open position to a closed position to clamp the sheet (2a), by the action, for example, of push and / or push cables. The clamp (16) is connected to the artificial cord (7) to slide along it when the second set (13) is introduced into the left atrium (3) of the heart (4). For this purpose, the clamp (16) comprises an upper jaw (16b), and a lower jaw (16a) equipped with a valve (17) articulated to adopt a closed position (see Figures 22 to 26) in which it encloses and maintains the artificial cord (7), while allowing the gripper (16) to slide around and along said artificial cord (7), and an open position (see FIGS. 21 and 27) for releasing the artificial cord (7 ).
Figures 21 to 28 illustrate the different steps implemented by the device in the steps illustrated in Figures 16 to 20. With reference to these figures, the clamp (16) is intended to pinch the sheet (2a) (Cf. figures 17 and 24), while being connected to the artificial cord (7). The jaws (16a, 16b) of the clamp (16) are both perforated to allow a needle (18), which is arranged inside and along the second manipulation rod (14), to move to drill and cross the thickness of the sheet (2a) of the valve (2) (see Figures 25).
The needle (18) fixes the artificial cord (7) to the sheet (2a) of the mitral valve (2). To do this, the needle (18), after having crossed the sheet (2a) can grasp the artificial cord (7) maintained by the valve (17), and be withdrawn to make the artificial cord (7) pass through said sheet (2a) for fixing it, in particular by knotting.
The needle (18) therefore has means for gripping the artificial cord (7), for example in the form of an inclined notch forming a hook at the end of the needle (18).
According to another technique, illustrated in FIGS. 18 to 20 and 26 to 28, the needle (18) has internally a suture (19) with shape memory, capable of being extracted to pass through the thickness of the sheet (2a), and forming a loop, again crossing the thickness of the sheet (2a), to attach the artificial cord (7) to said sheet (2a).
In this latter configuration, and with reference to FIGS. 19-20 and 27-28, the artificial cord (7) is fixed to the pillar (8) by means of a clip (9), and to the sheet (2a) by through a shape memory suture (19), forming a loop.
The characteristics of the device (1) according to the invention provide numerous advantages over existing solutions. Going through the transfemoral route reduces the duration and invasiveness of the operation. Note that the staples (9), and the clips (16) used are radio-opaque, or else include radioopaque and / or ultrasound markers allowing the surgeon to perform a 2D or 3D control of their position, as and as the operation progresses. Advantageously, the staples (9) used are sheathed in textile to facilitate their rehabilitation by human tissue.
权利要求:
Claims (2)
[1" id="c-fr-0001]
Device (1) for repairing a cord of the mitral valve (2) of a heart (4) by the transfemoral route, and intended to be positioned in a sealed introducer disposed in a femoral vein (percutaneous transfemoral access) to penetrate into the left atrium (3) of the heart (4) passing through its septal wall (trans-septal), characterized in that it comprises:
a first assembly (6) able to cooperate with a handle subject to control means for actuating the assembly for the establishment and fixing of an artificial cord (7) on the pillar (8) of a broken cord, said assembly is arranged at the end of a handling rod (5) and comprises an elastic staple (9) pivotally and removably connected to the end of the rod (5) so as to pass, under the action of the control means, from a folded position along the rod (5) to a position tilted angularly relative to the rod (5), to be placed perpendicularly opposite the pillar where the rope is to be replaced, the first assembly (6) comprises means for opening the clip (9) for, under the action of the control means, stapling the pillar (8) of the broken cord, the first assembly (6) comprises means for unlocking allowing, under the action of the control means, to release the clip ( 9), said clip (9) being connected to an artificial cord (7) which rises in the rod (5);
a second assembly (13) able to cooperate with a handle subject to control means for actuating the assembly for the establishment and fixing of the artificial cord (7) to a sheet (2a) of the valve ( 2), the second assembly (13) is arranged at the end of a handling rod (14) and comprises fixing means (9, 16) intended to slide along the artificial rope (7) and so connected pivoting at the end of the rod (14) so as to pass, under the action of the control means, from a folded position along the rod (14) to a position tilted angularly relative to the rod (14 ), to be placed parallel to the mitral sheet, the fixing means (9, 16) being able, under the action of the control means, to fix the artificial cord (7) to said sheet (2a).
Device (1) according to claim 1, characterized in that the fixing means (9, 16) comprise an elastic staple (9), openable, repositionable and removable, means for opening the staple (9), and means for unlocking the clip (9) similar to those of the first set (6), the clip (9) of the second set (13) being intended to be anchored on the sheet (2a) to fix the rope therein artificial (7).
3. Device (1) according to claim 2, characterized in that the artificial cord (7)
5 is notched, and the clip (9) of the second set (13) comprises means for sliding on the artificial rope (7) notched only in the direction of the clip (9) of the first set (6).
4. Device (1) according to claim 2, characterized in that the clip (9) of the
10 second set (13) comprises a wire (15) intended to form a fixing loop around the artificial cord (7), the artificial cord (7) being able to be tied around said loop.
5. Device (1) according to claim 2, characterized in that the second set
15 (13) comprises a stabilizing clamp pivotally connected to the end of the rod (14) so as to pass, under the action of the control means, from a folded position along the rod (14) to a position tilted angularly to the rod (14), to be parallel to the plane of the sheet and from an open position to a closed position for pinching and stabilizing the sheet (2a) for stapling.
6. Device (1) according to claim 1, characterized in that the fixing means (9, 16) comprise a clamp (16) pivotally connected to the end of the rod (14) so as to pass under the action of the control means, from a folded position along the rod (14) to a position tilted angularly to the rod (14),
25 to be parallel to the plane of the sheet fabric and from an open position to a closed position for pinching the sheet (2a), the second assembly (13) comprising a needle (18) movable to come, under the action of control means, pierce the sheet (2a) through an opening presented by the clamp (16) and fix the artificial cord (7) to the sheet (2a).
7. Device (1) according to claim 6, characterized in that the needle (18) internally comprises a suture (19) with shape memory capable of being extracted to form a loop to fix the artificial cord (7) to the sheet (2a).
8. Device (1) according to claim 6, characterized in that the needle (18) comprises means for gripping the artificial cord (7) after piercing the sheet (2a).
9. Device (1) according to claim 1, characterized in that the clip (9) comprises
5 two elastic branches (9a) brought together with hooked end portions (9b), the opening / unlocking means comprise two arms (12) arranged between the elastic branches (9a) of the 'clip (9) and articulated around a pivot (11) so as to pass, under the action of the control means, from a position close to one another to a separated position by forcing
10 the spacing of the branches of the clip (9) to cause it to open, the two arms (12) being retractable to allow the release of the removable clip (9).
10. Device (1) according to claim 6, characterized in that the clamp (16) comprises an upper jaw (16b) and a lower jaw (16a), perforated for the passage of
15 the needle (18), the lower jaw (16a) comprises a valve (17) intended to adopt a closed position to maintain the artificial cord (7), while allowing the clamp (16) to slide around and along said artificial cord (7), and an open position for releasing the artificial cord (7).
1/7
3 3
[2" id="c-fr-0002]
2/7
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US10945718B2|2014-09-17|2021-03-16|Cardiomech As|Device for heart repair|
US9345573B2|2012-05-30|2016-05-24|Neovasc Tiara Inc.|Methods and apparatus for loading a prosthesis onto a delivery system|
CN111263622A|2017-08-25|2020-06-09|内奥瓦斯克迪亚拉公司|Sequentially deployed transcatheter mitral valve prosthesis|
EP3796876A1|2018-05-22|2021-03-31|Boston Scientific Scimed, Inc.|Percutaneous papillary muscle relocation|
CN110934664A|2018-09-25|2020-03-31|先健科技有限公司|Heart valve|
法律状态:
2018-03-29| PLFP| Fee payment|Year of fee payment: 2 |
2018-09-14| PLSC| Publication of the preliminary search report|Effective date: 20180914 |
2020-03-24| PLFP| Fee payment|Year of fee payment: 4 |
2021-03-25| PLFP| Fee payment|Year of fee payment: 5 |
优先权:
申请号 | 申请日 | 专利标题
FR1752019|2017-03-13|
FR1752019A|FR3063631B1|2017-03-13|2017-03-13|DEVICE FOR REPAIRING MITRAL VALVE CORDAGES FROM A HEART BY A TRANSFEMORAL PATH|FR1752019A| FR3063631B1|2017-03-13|2017-03-13|DEVICE FOR REPAIRING MITRAL VALVE CORDAGES FROM A HEART BY A TRANSFEMORAL PATH|
PCT/FR2018/050243| WO2018167388A1|2017-03-13|2018-02-01|Device for transfemoral repair of the mitral valve chordae of a heart|
EP18713714.6A| EP3573544B1|2017-03-13|2018-02-01|Device for transfemoral repair of the mitral valve chordae of a heart|
US16/493,315| US11191643B2|2017-03-13|2018-02-01|Device for repair of the cords of the mitral valve of a heart by transfemoral approach|
IL26925719A| IL269257D0|2017-03-13|2019-09-10|Device for transfemoral repair of the mitral valve chordae of a heart|
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