• 专利附录
  • 专利说明
  • 权利要求
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    • 专利摘要:
    This invention relates to a container (100) for storing medical and / or pharmaceutical products. The container comprises a plastic container body (102) including a side wall (202), a bottom (204) and an opening (206) defining a storage volume (108), a flange (104) formed on the body container (102) configured to receive a connecting member (312) of a plug (310) having tamper means (414), and an active insert (106) disposed within the body container (102). This container forms an improved container for storing medical and / or pharmaceutical products.
    公开号:FR3063282A1
    申请号:FR1751525
    申请日:2017-02-24
    公开日:2018-08-31
    发明作者:Bernardo Romeo；Valere Logel；Jacquy LEBON
    申请人:Clariant Healthcare Packaging France SAS；
    IPC主号:
    专利说明:

    Holder (s): CLARIANT HEALTHCARE PACKAGING (FRANCE) SAS Simplified joint-stock company.
    Extension request (s)
    Agent (s): BANDPAY & GREUTER.
    CONTAINER FOR MEDICAL AND / OR PHARMACEUTICAL PRODUCTS.
    FR 3 063 282 - A1 (5 / j This invention relates to a container (100) for storing medical and / or pharmaceutical products. The container comprises a plastic container body (102) comprising a side wall (202) , a bottom (204) and an opening (206) defining a storage volume (108), a flange (104) formed on the container body (102) and configured to receive a connection element (312) of a plug (310) provided with a tamper-evident means (414), and an active insert (106), disposed inside the container body (102).
    This container forms an improved container for the storage of medical and / or pharmaceutical products.

    ι
    CONTAINER FOR MEDICAL AND / OR PHARMACEUTICAL PRODUCTS
    FIELD OF THE INVENTION
    The present invention relates to a container for storing medical and / or pharmaceutical products and to a method for manufacturing this container.
    TECHNICAL BACKGROUND
    Document US 8,875,917 B2 describes a container which receives products stored in bulk such as pills or tablets, in particular effervescent tablets. One objective is to provide a closure cap for a container which exhibits improved storage performance and which can be manufactured cost effectively. The closure cap comprises a cover part connected by a hinge to a connection element intended to be fixed on a container body. The cover part comprises a skirt sealingly engaging in an opening of the container body and a dehydration chamber. The container body includes a flange which is used to securely receive an annular member for connecting the closure cap. The annular element can be snapped onto the flange (positive adjustment). The stopper comprises breakable tamper-evident links between the cover part and the annular part. During the first use, the user must first break the tamper-evident bridges to open the closure cap and access the products stored inside the container. Consequently, if the tamper-evident bridges are intact, the consumer is sure that the container has not been opened.
    The plug further comprises a dewatering housing for receiving a desiccant, for example silica gel, calcium chloride, molecular sieve, other drying agents or any mixture thereof. These active agents allow moisture to be removed from the interior of the container body to preserve stored moisture-sensitive products. Moisture comes from the external environment and can, for example, enter the interior of the container when it is filled with the products to be stored, but also during its storage, by permeation (diffusion) through the walls. of the container or via the seal between the container and its cap, or even during its use by the consumer by the repeated opening and closing of the container. The dehydration housing thus makes it possible to increase the period of preservation and storage of the products contained in the container.
    CLA.00472. FR1-2017.02.24-DESC
    In this context, there is a need to provide an improved container for the storage of medical and / or pharmaceutical products sensitive to humidity and / or to other gaseous substances, such as oxygen or volatile organic compounds. In particular, there is a need to provide an improved container that is reliable, easy to handle, economical, avoiding the problems of leaking desiccant or atmospheric treatment agents from inside the container, and making it possible to absorb the humidity and / or gaseous substances entering the container, even after a rapid opening / closing cycle while providing a tamper-evident indicator (first opening indicator).
    SUMMARY OF THE INVENTION
    A container is therefore proposed for the packaging of sensitive products, such as medical and / or pharmaceutical products, as described in the claims. The container includes a plastic container body. The container body includes a side wall, a bottom and an opening defining a storage volume. The container also includes an active insert inside the container body.
    The container also includes a flange configured to receive a connecting element of a plug comprising a tamper-evident means. The cap can be articulated (hinged cap) or not. It is preferably articulated.
    It is also proposed an assembly for the packaging of sensitive products, such as medical and / or pharmaceutical products, comprising the container assembled with a stopper comprising a tamper-evident means, preferably an articulated stopper.
    This container has the safety characteristics of containers having a tamper-evident system, said safety characteristics being particularly important in the field of containers for the storage of medical and / or pharmaceutical products. In this context, the presence of an active insert mounted inside the container body allows the use of a less bulky and lighter articulated cap, while ensuring better action on the periphery of the products. This container is compatible with existing filling lines as used to package sensitive products in a container and requires little or no modification for the packaging of sensitive products and the assembly of the cap on the container body. Compared to existing articulated caps, comprising a dehydration chamber, the assembly of the container and the articulated cap according to the present invention makes it possible to limit the obstruction of the opening.
    CLA.00472. FR1-2017.02.24-DESC for access to the contents of the container and the stopper is less inclined to fall, under the effect of its weight, on the container body.
    The container may not be delivered closed and may not require a step of opening the cover before being able to fill it and condition the products in the storage volume internal to the container. On the other hand, the container may include a tamper-evident witness (witness of the first opening of the container).
    The container may further include the cap assembled to the container body. The stopper is preferably articulated, that is to say that it is connected to the container body by means of a hinge. The container body and the stopper are configured to form an air and moisture tight seal between the container body and the stopper.
    The container may further include medical and / or pharmaceutical products stored within the storage volume. The container and / or the articulated cap can be configured to allow the distribution of the products.
    The active insert comprises an active material capable of acting on the atmosphere of the storage volume of the container. In other words, the active material is capable of acting on gaseous materials present in the storage volume of the container. The action makes it possible to maintain the quality of sensitive products during their storage, for example maintaining physical and / or chemical integrity as much as possible and / or for as long as possible, in particular by protecting the products against gaseous substances liable to harm their integrity and / or their properties. The active insert is preferably formed from a material comprising a polymer and at least one active agent capable of trapping and / or releasing one or more gaseous substance (s), such as, for example, humidity, oxygen and / or a volatile organic compound.
    Medical and / or pharmaceutical products can include any product having a medical and / or pharmaceutical function. This can include products such as test strips, drugs, dietary supplements, pills, tablets, capsules, tablets, granules and powders. The container and / or the cap, preferably articulated, can be configured to meet the air tightness and protection requirements necessary for this medical and / or pharmaceutical function when the container is closed by the cap. Likewise, the plastic material of the container body can be compatible with such a medical and / or pharmaceutical function.
    CLA.00472. FR1-2017.02.24-DESC
    The container body can be of any shape. The container body may have a generally tubular shape. By tubular shape is meant a shape of a cylinder with a circular or non-circular base. For example, the base can be a disc, an oval, a square, a rectangle, a regular or irregular polygon, or even a combination of planar surfaces and / or curved surfaces. In addition, the diameter and / or thickness of the tubular wall may vary at least partially along the length of the tubular wall of the container body.
    In examples, the container may additionally have any or any combination of the following characteristics:
    - The container body has a generally cylindrical shape.
    - The container body is injection molded.
    - The plastic material of the container body has a low permeability to humidity and / or to oxygen, preferably to humidity. The plastic material can be chosen from polyolefins (polyethylene, polypropylene), polyesters, polycarbonate, cycloolefins, preferably polyolefins, in particular polypropylene and / or polyethylene.
    - The active insert comprises a generally tubular side wall.
    - The lower end of the side wall of the active insert is closed by a bottom.
    - The active insert is molded separately from the container body, then inserted into the container body, for example by pushing the active insert into the container body or by mounting the container body on the active insert.
    - The active insert can be molded directly with the container body, in particular by overmolding.
    - Alternatively, the active insert can be molded separately from the container body, then assembled inside the container body. In the latter case, the active insert can be held by pressing or clamping at least part of its side wall on a peripheral portion of the internal surface of the side wall of the container body.
    - The active material comprises at least one active agent.
    - The active agent is an agent capable of interacting with at least one gaseous substance such as humidity, oxygen, volatile organic compounds and / or odors. In particular, the active agent is an agent capable of trapping and / or releasing at least one
    CLA.00472. FR1-2017.02.24-DESC gaseous substance such as humidity, oxygen, volatile organic compounds and / or odors.
    - The active agent is a desiccant and / or an oxygen absorber.
    - The desiccant is chosen from silica gel, calcium chloride, calcium oxide, clay, molecular sieve, zeolites or any combination of these.
    - The oxygen absorber is chosen from iron-based oxygen absorbers, ascorbic acid, polymer-based oxygen absorbers, or any combination of these.
    - The active material further comprises a polymer in which the active agent is entrained. The polymer may for example be a thermosetting or a thermoplastic, preferably a thermoplastic polymer.
    - The polymer is preferably substantially permeable to the gaseous substance interacting with the active agent. It can be chosen according to its transmission rate for the gaseous substance considered.
    - The polymer is chosen from polymers based on polyolefin, for example polyethylene, HDPE, LDPE, polypropylene (PP), polystyrene (PS), polyvinyl chloride (PVC), ethylene-vinyl acetate (EVA), an ethylene-vinyl acetate copolymer (EVOH), a cyclic olefin copolymer (COC); polyester-based polymers, for example polycaprolactone (PCD), polylactic acid (PLA), polyethylene terephthalate (PET}, polybutylene terephthalate (PBT); polycarbonate (PC), polyoxymethylene (POM), polyamide, polyethylene sulfide PPS, BOPP or cellulose.
    - The flange is peripheral, and forms a fixing means disposed on the external surface of the side wall of the container body and configured to receive a plug.
    - The collar is preferably continuous, that is to say formed over an entire periphery of the container body; in another embodiment, the collar may be discontinuous.
    - The flange is located towards the upper end of the side wall of the container body near the opening of the container body. In other words, she is
    CLA.00472. FR1-2017.02.24-DESC arranged on a portion of the side wall of the container body which is adjacent to the opening of the container body.
    - The flange has a thickness measured vertically T1 at the point of junction with the container body which is less than the thickness measured horizontally T2 of the side wall of the container body. Preferably Tl <2/3 T2, preferably Tl <1/2 T2.
    - The collar is reinforced by a network of ribs joining the collar to the external surface of the side wall of the container body. These ribs are particularly useful for strengthening the collar when its thickness is very small.
    - The flange has a horizontal part, which extends from the side wall of the container body towards the outside and perpendicular to it. In other words, the horizontal part (or section) extends radially outward from the side wall of the container body.
    - The collar further comprises a vertical part which extends from the end of the horizontal part of the collar vertically. Preferably, the vertical part (or section) extends perpendicular to the horizontal part. It can extend towards the opening of the container body (i.e. upwards when the container body rests on its bottom) or towards the bottom of the container body (downwards) . Preferably the vertical part extends downwards.
    - The horizontal part of the collar includes a horizontal upper surface. This horizontal surface serves as a support for the plug connection element (preferably articulated) and makes it possible to immobilize and secure the plug vertically on the flange, preventing the plug from slipping off or taking off the flange, especially when too great a force is applied to the stopper, for example during the assembly phase of the stopper on the container body. This configuration has an advantage over existing flanges having an inclined upper surface, on which the plug connection element tends to slide along the flange or even pass below the flange once the plug is mounted on the container body. Another advantage is that, the plug being well maintained vertically on the flange, the axis of rotation of the hinge of the plug is fixed and well defined, which makes it possible to precisely define the rotation stroke of the plug during the opening cycles. and closing, and therefore the good
    CLA.00472. FR1-2017.02.24-DESC positioning and quality of its sealing means (or sealing means) in the closed position, for better air and moisture tightness.
    - The horizontal upper surface of the horizontal section includes, at its outer end, a rounded or chamfer. This allows easier mounting of the cap, in particular an easier assembly of the plug connecting element on the fixing means of the container body which requires less force. In addition, the radius makes it possible to guide and refocus the stopper around the flange during its assembly when the stopper is not perfectly aligned with the container body on the assembly lines.
    - The collar has a cross section of angular shape, preferably at an angle of 90 °. This angle is formed by the horizontal part and the vertical part of the flange.
    - The angular shape has a rounded upper surface; in other words, the horizontal upper surface of the horizontal section has a rounded shape, at its outer end from which the vertical section extends. Thus, the flange has a radius between the horizontal upper surface of the horizontal part and the external lateral surface of the vertical part. The rounded upper surface allows easier assembly of the stopper on the flange of the container body, requiring a little less precision for the alignment of the stopper with respect to the flange and less force for the latching of the annular connection means of the cap on the collar.
    - The angular shape has a chamfered upper surface. In other words, the angular shape has a chamfer between the horizontal upper surface of the horizontal part and the external lateral surface of the vertical part. The chamfered upper surface also facilitates assembly of the cap on the flange of the container body.
    - The angular shape has a right angle between the upper horizontal surface of the horizontal part and the outer lateral surface of the vertical part.
    - The thickness of the horizontal part of the collar is smaller than the thickness of the vertical part.
    CLA.00472. FR1-2017.02.24-DESC
    - The thickness of the horizontal part of the flange is smaller than the thickness of the side wall of the container body.
    - The ratio between the thickness of the horizontal part of the flange and the thickness of the side wall of the container body on the area adjacent to the horizontal part is 2 less than or equal to -, preferably K terms, the thickness of the horizontal part represents at most 2/3 of the thickness of the wall of the container body, taken at its junction with the horizontal part of the flange. This thickness makes it possible in particular to avoid shrinkage (deformation or hollow) on the internal surface of the container body directly adjacent to the collar, and thus, to guarantee a well-defined internal surface on this zone, even by using cycle times. short cooling during manufacture, for example by injection molding, of the container body.
    - The container further comprises a stopper, preferably articulated. The cap is molded independently of the container body and assembled to the container body via the flange. This has the particular advantage of being able to use different materials and / or colors for the cap and for the container body.
    - The cap comprises an annular connection element configured to be fixed on the flange of the container body, a cover part configured to close the opening of the container body in a leaktight manner and a tamper-evident means between the cover part at the connecting element.
    - The stopper can be a tamper-evident stopper without a hinge, which therefore separates from the container body when the latter is open. This type of plug generally comprises a cover part, an annular connection element and a tamper-evident means, such as a plurality of breakable links between the connection element and the cover part. When the cap is closed for the first time after filling the products in the storage volume, the annular connection element snaps onto the flange of the container body.
    - According to a preferred embodiment, the stopper is an articulated stopper (or hinged stopper). Such an articulated plug comprises a hinge connecting the cover part to the annular connection element. In this way, the articulated stopper remains integral with the container during the opening and closing cycles of the container,
    CLA.00472. FR1-2017.02.24-DESC even after the first opening by the consumer. An articulated, tamper-evident cap comprising an annular connection element is for example described in document US 8,875,917 B2.
    - The cap, preferably articulated, is configured to cooperate with the side wall of the container body so as to form an airtight seal. This allows better protection of sensitive products to be stored.
    - The cap is made of plastic. The plastic may be the same or different from that of the container body. Preferably the plastic is different from that of the container body. For example, it may be advantageous to use a more flexible material (for example slightly) for the cap than that of the container body.
    - The cap is injection molded.
    - The plastic of the plug has a low permeability to humidity and / or to oxygen, preferably to humidity. The plastic can be chosen from polyolefins (polyethylene, polypropylene), polyesters, polycarbonate, cycloolefins, preferably polyolefins, in particular polypropylene and / or polyethylene.
    - The cap can be mono-material or injected in two different materials to combine the barrier properties of materials against different gases (an oxygen barrier material combined with a moisture barrier material for example) or even to combine the properties barrier of a first material with the elastic properties of a second material to form the hinge and / or form a flexible seal.
    - The cap is molded in one piece. When the plug is articulated, it is preferably molded in the closed position.
    - The plug connection element comprises, on its internal surface, a recess intended to cooperate with the flange of the container body.
    - The cover part has a sealing surface configured to cooperate with a sealing surface arranged on the container body so as to form an airtight seal between the cap and the container body when the cap is in position closed.
    CLA.00472. FR1-2017.02.24-DESC
    - The cover part includes a sealing skirt. The sealing skirt is configured to cooperate with the container body so as to form an airtight seal. In other words, the sealing surface of the cover part is located on this sealing skirt. Preferably, the sealing skirt includes a bulge on its lower part. The sealing skirt extends in a direction substantially perpendicular to the upper wall of the cover from the inner face of the cover. It preferably includes a bulge located towards the lower end of the sealing skirt (the free end of the skirt opposite the end by which the skirt is attached to the internal face of the upper wall of the cover). The bulge is oriented towards the side wall of the container body. The bulge formed on the sealing skirt of the lid part can thus constitute the sealing surface of the lid which cooperates with the side wall of the container body so as to form an airtight seal when the cap is in position. closed.
    - Preferably, the sealing skirt of the cover which cooperates with the side wall of the container body forms the only sealing surface between the plug and the container body.
    - The sealing surface of the container body is located on the side wall of the container body, preferably on the internal surface of the side wall of the container body. The sealing surface of the container body may be located on a flat portion of the inner surface of the side wall of the container body or may be located in a peripheral groove and / or a peripheral bulge formed on the internal surface of the wall side of the container body.
    - The sealing surface of the container body configured to cooperate with the sealing surface of the cover part is arranged in a peripheral groove on the internal surface of the side wall of the container body.
    - The radius of the annular groove is greater than the radius of the bulge located on the sealing skirt.
    - The sealing surface of the container body is preferably not axially adjacent to the peripheral flange (not vertically aligned).
    CLA.00472. FR1-2017.02.24-DESC
    - The plug connection element, preferably articulated, is configured to be snapped on (that is to say to form a positive engagement) on the flange.
    - The plug connection element, preferably articulated, is an annular element.
    - The plug connection element comprises, on its internal surface, a vertical cylindrical surface S5 which cooperates with the vertical part of the flange S4 once the plug is assembled on the container body. Preferably, the diameter of the vertical cylindrical surface S5 of the connecting element is less than the outside diameter of the vertical part S4 of the flange before the cap is assembled on the container body.
    - The plug connection element is made of a resilient material which allows its diametrical extension after assembly on the container body. In this way and after assembly of the stopper on the container body, the connection element of the stopper exerts pressure on the flange, thus limiting the rotation of the stopper around the container body, particularly that of an open articulated stopper.
    - The cap, preferably articulated, further comprises a tamper-evident means
    - The tamper-evident means comprises at least one breakable link connecting the cover part to the connection element, preferably a plurality of breakable links.
    - The tamper-evident means comprises a tearable strip connecting the cover part to the connection element.
    - The tamper-evident means is broken when the cap is opened for the first time.
    - The cap, preferably articulated, does not include a desiccant chamber and / or active agent.
    - The stopper, preferably articulated, comprises an opening means comprising a gripping portion and / or a cavity in the cover part.
    The plug, preferably articulated, has a total height of less than 15 mm, preferably less than 12 mm,
    - The cap, preferably articulated, has a total weight of less than 3 g.
    - When the cap closes the opening of the container body, the container has a humidity penetration rate W of less than 1 mg / day at 40 ° C and 75% humidity
    CLA.00472. FR1-2017.02.24-Relative DESC (HR), established according to the standard method ASTM D7709-12, preferably less than 0.7 mg / day, preferably less than 0.5 mg / day.
    - The humidity penetration rate is notably a function of the length of the seal between the cap and the container body. When the cap closes the opening of the container body, the container has a moisture penetration rate W of less than 10 pg / day / mm of length of the seal, preferably less than 7 pg / day / mm of length of the seal surface seal at 40 ° C and 75% relative humidity (RH), In other words, for a circular container comprising a seal with a diameter of 25 mm, the container has a humidity penetration rate of less than 785 pg / day at 40 ° C and 75% RH.
    - The humidity penetration rate also depends on the dimensions and construction materials of the container. Considering:
    o W the humidity penetration rate of the container closed by its cap and established at 40 ° C, 75% rH according to the standard method ASTM D7709-12, o S the total external surface of the container S in m2, oe the thickness mean of the container in mm, the moisture permeability of the container closed by its cap P = We / S is less than 220 mg.mm/m 2 .day preferably 160 mg.mm/m 2 .day, preferably 120mg .mm / m2.day at 40 ° C, 75% rH.
    The invention also relates to a method of manufacturing the container. The method comprises the manufacture of a container body as described in the claims, in particular by thermoplastic injection molding. The method also includes molding an active insert, in particular by thermoplastic injection molding, and assembling it inside the container body.
    The active insert can be assembled in the container body by any assembly technique known from the state of the art such as, for example, clamping and friction holding, snap-fastening, welding, bonding.
    Alternatively, the container can be obtained by overmolding, for example the container body can be overmolded around an active insert injected beforehand or vice versa by any techniques known in the plastics industry such as insert molding, bi-injection, co- molding, two-component injection.
    CLA.00472. FR1-2017.02.24-DESC
    The invention also relates to the use of such a container for the storage and / or packaging of medical and / or pharmaceutical products. Among the sensitive products, there may be mentioned, for example, drugs, such as effervescent tablets or not, capsules, granules, powders, food supplements such as vitamins or minerals, but also diagnostic strips.
    The invention also relates to a method of filling this container with medical and / or pharmaceutical products. The process includes:
    - the supply of a container comprising an active insert placed inside a container body provided with a collar configured to receive a connection element of a plug, preferably articulated, provided with a means of inviolability,
    - filling the container body with medical and / or pharmaceutical products, and
    - The assembly of a stopper, preferably articulated, provided with a tamper-evident means on the container body, preferably by applying vertical pressure on the stopper.
    The assembly is carried out by snap-fastening of the plug connection element on the flange of the container body.
    The container body can be conveyed on conventional filling lines designed for a snap closure of a stopper on the container body: after filling the products in the container body provided with its active insert, the container body is conveyed to an assembly station where a cap supply line deposits the cap on the opening of the container body and where vertical pressure is applied to snap and secure the cap on the flange of the container body.
    Another object of the invention relates to a container for packaging medical and / or pharmaceutical products comprising:
    a plastic container body comprising a side wall, a bottom and an opening defining a storage volume, and
    - A collar formed on the container body and configured to receive a connecting element of a plug, preferably articulated, provided with a tamper-evident means.
    This container may also have an active insert and / or any one or any combination of the characteristics mentioned above.
    CLA.00472. FR1-2017.02.24-DESC
    BRIEF DESCRIPTION OF THE DRAWINGS
    Figures 1-2 respectively represent a perspective view and a sectional view of an example of a container according to the invention.
    FIG. 3 represents an enlarged sectional view of the zone B of FIG. 2.
    Figures 4-5 show side and front views of the container fitted with an articulated cap.
    FIG. 6 represents a sectional view along the plane A-A of FIG. 4.
    Figure 7 shows an enlarged sectional view of the container according to another embodiment, comprising a stopper.
    Figure 8 shows an enlarged sectional view of the container according to another embodiment with another example of flange.
    DETAILED DESCRIPTION OF THE INVENTION
    The references below are used in the figures:
    100 container (without cap)
    102 container body
    103 horizontal part of the collar 104
    104 flange
    105 vertical part of the flange 104
    106 active insert
    107 flared upper part of the active insert 106
    108 storage volume
    109 external surface of the active insert 106
    118 peripheral cavity on the internal surface of the container body 102
    150 zone of the junction between the flange 104 and the side wall 202 of the container body
    202 side wall of the container body 102 204 bottom of the container body 102 206 opening of the container body 102 300 container (with stopper) moisture-proof 310 articulated stopper
    312 annular connection element 314 cover part
    CLA.00472. FR1-2017.02.24-DESC
    315 sealing skirt
    318 bulge of the sealing skirt 315
    321 protrusion on the internal surface of the connection element 323 protrusion on the internal surface of the connection element 325 recess on the internal surface of the connection element 412 hinge (connecting the cover part 314 to the annular element 312 )
    414 means of inviolability
    512 gripping portion (opening method)
    514 cavity part (opening means)
    602 side wall of the active insert 604 bottom of the active insert
    700 container
    702 container body
    703 horizontal section of the collar 704
    704 flange
    706 active insert 800 container
    802 container body
    803 horizontal section of the collar 804
    804 collar
    806 active insert external surface of the side wall 202 of the container body 102 internal surface of the side wall 202 of the container body 102 horizontal upper surface of the horizontal part 103 external side surface of the vertical part internal surface of the connecting element of the plug T1 thickness of the horizontal part 103 of the collar 104
    T2 thickness T2 of the side wall 202 of the container body 102
    FIGs. 1-3 represent a container 100 without cap. The container 100 comprises a plastic container body 102 defining a storage volume 108, a flange 104 formed on the container body 102 and an active insert 106 mounted inside the container body 102.
    CLA.00472. FR1-2017.02.24-DESC
    FIGs. 4-6 show a container 300 consisting of the container 100 of FIGS. 1 to 3 and of an articulated stopper 310 assembled to the container body 102. The articulated stopper 310 comprises an annular connection element 312, which is fixed to the flange 104, a cover part 314 and a hinge 412 connecting the cover part 314 to the annular element 312.
    The container can be obtained by molding the container body 102, preferably by injection, then for example by assembling the active insert 106 inside the container body 102. The active insert 106 can be mounted inside of the container body 102, for example by pushing down the active insert 106 in the container body 102.
    The process can then be followed by filling the container 100 with medical and / or pharmaceutical products. The filling can include the insertion of medical and / or pharmaceutical products into the container 100 and the assembly of the articulated stopper 310 to the container body 102 so as to obtain a moisture-proof container 300. The assembly can be carried out by conveying a stopper over a container body then applying a downward vertical force on the stopper so that the annular connection means of the stopper snaps onto the flange of the tube.
    The presence of the active insert 106 inside the container body 102 allows the use of an articulated cap which has a smaller footprint and weight than the articulated caps provided with a dehydration chamber. In particular, the articulated plug 310 does not contain any desiccant chamber and / or any active agent.
    The presence of the active insert 106 inside the container body 102 also reduces the risk of leakage of active agent compared to the solutions of the prior art using a plug comprising a chamber filled with desiccant. Indeed, the desiccant chambers of the prior art are generally closed by a cardboard disc which can be badly fixed (for example by crimping), which can move from its initial location or which can be damaged during the steps of handling the cap, especially when dispensing in bulk on packaging lines or when handled by the consumer.
    In addition, the active insert 106 is mounted inside the container body 102 and is therefore closer to the sensitive products stored in the container 100, compared to existing containers where the active agent is located in a dehydrating chamber of the cap. . In the figures, the active insert 106 surrounds said products. In other words, the active insert defines at least part of the storage volume. This proximity improves active function.
    CLA.00472. FR1-2017.02.24-DESC
    With reference to FIG. 1, the container body 102 has a generally cylindrical shape and the flange 104 is peripheral and continuous. The flange 104 is formed over the entire periphery of the container body 102. This allows simple manufacture and efficient holding of the cap once assembled on the flange.
    With reference to FIGs. 2-3, the container body 102 comprises a side wall 202, a bottom 204 and an opening 206 defining a storage volume 108.
    The container body 102 is further provided with a flange 104 which comprises a horizontal part 103 which extends perpendicularly from the external surface SI of the side wall 202 of the container body 102. The part 103 forms a ring on the body container 102. The part 103 comprises a horizontal upper surface S3. This surface S3 prevents the risk of downward movement of the annular connection element 312 of the articulated plug 310.
    Indeed, on the flanges of the prior art comprising an inclined upper surface, the annular connection element was capable of slipping or even disengaging from the flange when a strong vertical pressure was applied to the articulated plug 310. The plug articulated therefore has the advantage of being securely attached to the flange.
    Furthermore, the plug being well maintained on the flange, the axis of rotation of the hinge 412 remains fixed and well defined. The articulated stopper can therefore pivot along a fixed and well-defined axis of rotation, which allows good positioning of the sealing surfaces when the articulated stopper 310 is closed and therefore guarantees good airtightness between the stopper and the container body.
    The flange 104 further comprises a vertical part 105 which extends vertically and downwards from the periphery of the horizontal part 103. The part 105 forms a cylinder around the container body 102. Thus, the flange has a section transverse in the form of an angle, the angle here being 90 °. This angular shape allows a particularly good holding of the articulated stopper 310 on the collar.
    In the figures, the angular shape of the cross section of the flange 104 is rounded. In other words, the outer edges of the angular shape meet smoothly and a radius is present between the upper surface of the horizontal part 103 and the outer surface of the vertical part 105. This also allows easier snap-on, the articulated plug 310 being guided and refocused around the flange 104 during its
    CLA.00472. FR1-2017.02.24-DESC assembly on the container body 102 and to reduce the downward pressures necessary for the assembly of the articulated plug 310 on the container body 102.
    Other embodiments are also possible. For example, the angular shape of the cross section of the flange 104 can be chamfered or form a right angle. In the second case, this makes it possible to increase the horizontal upper surface of the horizontal part 103 and therefore further improve the behavior of the articulated plug on the flange.
    The horizontal part 103 has a thickness less than that of the side wall 202 of the container body 102 on the area adjacent to the flange. By this is meant that the thickness T1 of the horizontal part 103 is less than the thickness T2 of the side wall 202 of the container body 102 at the place where the flange 104 is formed on the container body 102. Plus 2 particularly, as illustrated in the figures, the Tl / T2 ratio is less than or equal to -, and preferably less than K This range of relative values makes it possible to reduce the risk of shrinkage (or surface defects due to an area 150 of accumulation of plastic material at the junction of the collar and the shrinking of this material during cooling) while having a sufficiently solid collar 104. Such a relative thickness of the horizontal part 103 thus allows a better quality of the internal surface of the container body 102 which can have a decisive impact on the quality of the airtightness of the container.
    With reference to FIGs. 2, 3 and 6, the cover 314 comprises a sealing skirt 315 which has a bulge 318. Furthermore, the internal surface of the container body 102 comprises a peripheral cavity 118. When the cap closes the opening of the container body , the bulge 318 formed on the sealing skirt 315 cooperates with the peripheral cavity 118 of the side wall 202 of the container body 102 so as to form an airtight seal. In this way, the storage volume 108 is sealed off from the atmosphere outside the container.
    The internal surface S2 of the side wall 202 of the container body 102 is configured to hold the active insert 106 inside the container body 102. For example, the active insert can be held by tightening.
    In FIG. 7, the container 700 comprises a container body 702 and an active insert 706. The plug connection element comprises, on its internal surface,
    CLA.00472. FR1-2017.02.24-DESC protrusions 321 and 323 intended to receive and fix the flange 704 of the container body 702. The plug connection element comprises, on its internal surface, a recess 325 (formed between the protrusions 321 and 323 ), intended to cooperate with the flange of the container body. In addition, the stopper 310 comprises a sealing skirt comprising a bulge 318 which cooperates with a peripheral cavity 118 on the internal surface of the side wall 202 of the container body 702.
    The plug connection element comprises, on its internal surface, a vertical cylindrical surface S5 which cooperates with the vertical part of the collar S4 once the plug is assembled on the container body. Preferably, the diameter of the vertical cylindrical surface S5 of the connecting element is less than the outside diameter of the vertical part S4 of the flange before the cap is assembled on the container body. The plug connection element is made of a resilient material which allows the diameter of the vertical cylindrical wall of the connection element to increase during assembly on the body of the container. In this way and after assembly of the cap on the container body, the connection element of the cap exerts pressure on the vertical surface of the flange, limiting the rotation of the cap around the container body, particularly in the case of a open hinged cap.
    FIG. 8 shows a container body 802 in which the flange has only a horizontal part 803. This horizontal part 803 is disposed at the upper end of the side wall of the container body but can be disposed on another portion of the side wall of the container body. The horizontal part 803 comprises a horizontal upper surface S3 which is rounded at its external end in order to facilitate the assembly of the plug on the flange.
    With reference to FIGs. 4-6, the articulated stopper 310 comprises a tamper-evident means comprising breakable links (or bridged) 414 connecting the cover part 314 to the annular connection element 312. The breakable links 414 are broken at the first opening of the articulated stopper 310, which is then visible to the consumer.
    The articulated plug 310 is also provided with an opening means comprising a gripping portion 512 formed in the cover part 314 and a cavity part 514 formed in the cover part 314 and / or in the annular element 312. Such a means opening is ergonomic. Such a plug can for example be injection molded using drawer molds.
    CLA.00472. FR1-2017.02.24-DESC
    权利要求:
    Claims (16)
    [1" id="c-fr-0001]
    1. Container (100,300) for the packaging of medical and / or pharmaceutical products comprising:
    a container body (102) of plastic material comprising a side wall (202), a bottom (204) and an opening (206) defining a storage volume (108),
    - a collar (104) formed on the container body (102) and configured to receive a connection element (312) of a plug, preferably articulated, (310) provided with a tamper-evident means (414), and
    - an active insert (106), disposed inside the container body (102).
    [2" id="c-fr-0002]
    2. Container according to claim 1, in which the active insert (106) is formed from a material comprising a polymer and at least one active agent capable of interacting with one or more gaseous substance (s) among the humidity, oxygen and / or a volatile organic compound.
    [3" id="c-fr-0003]
    3. Container according to claim 1 or 2, wherein the flange (104) has a part (103) which extends from the side wall (202) of the container body (102) outwards, the part (103 ) which extends from the side wall (202) of the container body (102) outwards preferably being a horizontal part (103) at least substantially perpendicular to the side wall (202) of the container body (102) .
    [4" id="c-fr-0004]
    4. Container according to claim 3, wherein the thickness of the horizontal part (103) of the collar (104) is less than the thickness of the side wall (202) of the container body (102), taken on the area adjacent to the horizontal part (103).
    [5" id="c-fr-0005]
    5. Container according to claims 3 or 4, in which the ratio between the thickness of the horizontal part (103) of the flange (104) and the thickness of the side wall (202) of the container body (102), taken on the zone (150) adjacent to the horizontal part (103), is lower
    2 1 or equal to -, preferably less than or equal to
    CLA.00472.FR1-2017.05.26-IRREG-CLMS
    [6" id="c-fr-0006]
    6. Container according to any one of claims 3 to 5, in which the collar (104) further comprises a vertical section (105) which extends vertically from the end of the horizontal section (103) of the collar ( 104).
    [7" id="c-fr-0007]
    7. Container according to claim 6, wherein the flange (104) has a cross section of angular shape, at an angle of 90 °.
    [8" id="c-fr-0008]
    8. Container according to any one of the preceding claims, in which the collar (104) is a peripheral collar, preferably continuous.
    [9" id="c-fr-0009]
    9. Container according to any one of the preceding claims, in which the horizontal upper surface (S3) of the horizontal section (103) comprises, at its external end, a rounded or a chamfer.
    [10" id="c-fr-0010]
    10. Container according to any one of the preceding claims, further comprising a stopper (310) provided with a tamper-evident means (414) and assembled to the container body (102), the stopper being preferably articulated.
    [11" id="c-fr-0011]
    11. The container of claim 10, wherein the plug (310) is configured to cooperate with the side wall (202) of the container body (102) so as to form an airtight seal.
    [12" id="c-fr-0012]
    12. Container according to claim 10 or 11, having a humidity penetration rate of less than 1 mg / day at 40 ° C and 75% relative humidity.
    [13" id="c-fr-0013]
    13. Container according to any one of claims 10 to 12, having a moisture penetration rate of less than 10 pg / day / mm of seal length at 40 ° C and 75% relative humidity.
    [14" id="c-fr-0014]
    14. Container according to any one of claims 10 to 13, having a humidity penetration rate of less than 220 mg.mm/m 2 .day at 40 ° C and 75% relative humidity.
    CLA.00472.FR1-2017.05.26-IRREG-CLMS
    [15" id="c-fr-0015]
    15. A method of manufacturing a container according to any one of claims 10 to 14, comprising:
    - the supply of a container comprising an active insert (106) disposed inside a container body (102) provided with a collar (104) configured to receive a
    5 connection element (312) of a plug (310) provided with a tamper-evident means (414), the plug preferably being articulated,
    - filling the container body (102) with medical and / or pharmaceutical products, and
    - The assembly of the cap (310) on the container body (102), preferably by
    10 application of a downward vertical pressure on the plug.
    [16" id="c-fr-0016]
    16. The use of a container according to any one of claims 1 to 14 for the packaging of medical and / or pharmaceutical products.
    CLA.00472.FR1-2017.05.26-IRREG-CLMS
    1/8
    类似技术:
    公开号 | 公开日 | 专利标题
    EP2024253B1|2009-10-07|Sealed arrangement comprising a flow-limiting device, for the storage and dispensing of solid pharmaceutical products
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    FR3063282A1|2018-08-31|CONTAINER FOR MEDICAL AND / OR PHARMACEUTICAL PRODUCTS
    US20050016873A1|2005-01-27|Desiccant vial assembly for effervescent tablets
    EP0680887A1|1995-11-08|Closure cap for a container provided with a collar presenting a single fixing flange
    EP2125553B1|2012-12-05|Dehydrating and reclosable hinged plug-lid with tamper indicator and compensation device
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    FR3076206A1|2019-07-05|CONTAINER FOR MEDICAL AND / OR PHARMACEUTICAL PRODUCTS WITH INTERSTICE
    BE1007750A6|1995-10-10|Plastic bottle.
    EP3196142B1|2018-09-12|Container and cap to be attached by snap-fitting to its neck
    WO2021099325A1|2021-05-27|Stopper having an incorporated metering device
    FR2581036A1|1986-10-31|Stopper allowing the closing of tubes and bottles, in particular for pharmaceutical products
    FR2742733A1|1997-06-27|Plastic container with cap removed by breaking seal
    BE881628A|1980-08-08|DISPENSING TIP FOR VISCOUS MATERIAL
    同族专利:
    公开号 | 公开日
    EP3585701A1|2020-01-01|
    WO2018153890A1|2018-08-30|
    CN110506008A|2019-11-26|
    TW201832749A|2018-09-16|
    CN208726269U|2019-04-12|
    KR20190126337A|2019-11-11|
    FR3063282B1|2020-11-20|
    US20190367247A1|2019-12-05|
    CN110506008B|2021-11-26|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    WO1996027533A1|1995-03-07|1996-09-12|Sarnatech Ammann S.A.|Stopper with a warranty strip|
    US20070272646A1|2003-12-19|2007-11-29|Didier Lancesseur|Device For The Leak-Tight Sealing Of Packaging Containers For Sensitive Products|
    US20160101914A1|2013-04-29|2016-04-14|Clariant Production Sas|Cap for a container|
    WO2016135226A1|2015-02-25|2016-09-01|Clariant Production S.A.S.|Container for loosely stored products and method for opening such container|
    EP3081505A1|2015-04-16|2016-10-19|Clariant Production S.A.S.|Tamper-evident closure and tamper-evident closure and container assembly|
    JP2006117305A|2004-10-25|2006-05-11|Coca Cola Co:The|Bottle cap|
    CN201154785Y|2008-02-20|2008-11-26|洪伟|Multifunctional double-refill bottle|
    US8875917B2|2008-05-15|2014-11-04|Clariant Production Sas|Closure cap with spring element for a container|
    DK2277799T3|2009-07-23|2012-05-21|Airsec Sas|Hydrated moisturizing agent and process for its preparation|US20180297752A1|2015-10-23|2018-10-18|Husky Injection Molding Systems Ltd.|Containers and closures|
    CN209337257U|2018-10-29|2019-09-03|江苏绿森包装有限公司|A kind of lid of paper-plastic container and the fastening structure of box|
    IL263644D0|2018-12-11|2020-06-30|I Katz Ltd|Tamper-resistant container with lid|
    法律状态:
    2018-02-23| PLFP| Fee payment|Year of fee payment: 2 |
    2018-08-31| PLSC| Publication of the preliminary search report|Effective date: 20180831 |
    2020-02-19| PLFP| Fee payment|Year of fee payment: 4 |
    2021-02-24| PLFP| Fee payment|Year of fee payment: 5 |
    2022-01-07| TP| Transmission of property|Owner name: AIRNOV, INC., US Effective date: 20211126 |
    2022-02-16| PLFP| Fee payment|Year of fee payment: 6 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1751525A|FR3063282B1|2017-02-24|2017-02-24|CONTAINER FOR MEDICAL AND / OR PHARMACEUTICAL PRODUCTS|
    FR1751525|2017-02-24|FR1751525A| FR3063282B1|2017-02-24|2017-02-24|CONTAINER FOR MEDICAL AND / OR PHARMACEUTICAL PRODUCTS|
    CN201721727371.5U| CN208726269U|2017-02-24|2017-12-12|The container of medical products and/or drug|
    EP18705011.7A| EP3585701A1|2017-02-24|2018-02-21|Container for medical and/or pharmaceutical products|
    PCT/EP2018/054228| WO2018153890A1|2017-02-24|2018-02-21|Container for medical and/or pharmaceutical products|
    CN201880013854.XA| CN110506008B|2017-02-24|2018-02-21|Container for medical and/or pharmaceutical products|
    KR1020197027774A| KR20190126337A|2017-02-24|2018-02-21|Containers for Medical and / or Pharmaceutical Products|
    US16/486,816| US20190367247A1|2017-02-24|2018-02-21|Container for medical and/or pharmaceutical products|
    TW107106218A| TW201832749A|2017-02-24|2018-02-23|Container for medical and/or pharmaceutical products|
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