• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
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  • 优先权
    • 专利摘要:
    The invention relates in particular to a device (100) for sampling a liquid in a container, characterized in that it comprises: - a housing (10) having a longitudinal axis (AL); a component (20, 20 ', 20 ") comprising: a body (26) provided with at least one channel (21) with a proximal end (21p) and a distal end (21d); (24), fixed relative to the body (26), and located in the extension of the proximal end (21 p) of said at least one channel (21), said component (20) being rotatably mounted relative to the housing ( 10) about the longitudinal axis of this housing (10) between a closed position in which the distal end (21 d) of said at least one channel (21) is closed by the housing (10) and a position of opening in which the distal end (21 d) of said at least one channel (21) is adapted to establish fluid communication with the container, and - an elastic valve (30) housed in the receptacle (24).
    公开号:FR3060305A1
    申请号:FR1662671
    申请日:2016-12-16
    公开日:2018-06-22
    发明作者:Laurie LABROC；Michel Robin；Daniel Aneas
    申请人:Virbac SA；
    IPC主号:
    专利说明:

    ® FRENCH REPUBLIC
    NATIONAL INSTITUTE OF INDUSTRIAL PROPERTY © Publication number:
    (to be used only for reproduction orders)
    ©) National registration number
    060,305
    62671
    COURBEVOIE © Int Cl 8 : A 61 J 1/20 (2017.01)
    PATENT INVENTION APPLICATION
    A1
    ©) Date of filing: 16.12.16. ©) Applicant (s): VIRBAC SA - FR. (30) Priority: @ Inventor (s): LABROC LAURIE, ROBIN MICHEL and ANEAS DANIEL. (43) Date of public availability of the request: 22.06.18 Bulletin 18/25. ©) List of documents cited in the report preliminary research: Refer to end of present booklet (© References to other national documents ® Holder (s): VIRBAC SA. related: ©) Extension request (s): ©) Agent (s): GEVERS & ORES Société anonyme.
    CONTAINED IN A CONTAINER, LINKED CONTAINER AND
    FR 3 060 305 - A1 (□ 4) DEVICE FOR COLLECTING A LIQUID USE OF THIS CONTAINER.
    ©) The invention relates in particular to a device (100) for withdrawing a liquid from a container, characterized in that it comprises:
    - a housing (10) having a longitudinal axis (AL);
    - a component (20, 20 ', 20) comprising:
    a body (26) provided with at least one channel (21) with a proximal end (21 p) and a distal end (21 d);
    a receptacle (24), fixed relative to the body (26), and located in the extension of the proximal end (21 p) of said at least one channel (21), said component (20) being mounted for rotation relative to the housing (10) around the longitudinal axis of this housing (10) between a closed position in which the distal end (21 d) of said at least one channel (21) is closed by the housing (10) and a position opening in which the distal end (21 d) of said at least one channel (21) is capable of establishing fluid communication with the container; and
    - an elastic valve (30) housed in the receptacle (24).
    DEVICE FOR COLLECTING A LIQUID CONTAINED IN A CONTAINER, RELATED CONTAINER AND USE OF THIS CONTAINER
    The invention relates to a device for withdrawing (or transferring) a liquid contained in a container.
    It also relates to a container provided with such a sampling device.
    It also relates to a use of this container.
    The invention mainly relates to an application to the sampling of a liquid of medicinal scope, in particular intended for the treatment of animals.
    This type of device allows the withdrawal of liquid while ensuring, moreover, a seal.
    To this end, a device has already been proposed for withdrawing liquid from a container, comprising a tap which allows a user, by turning this tap, to close or open a passage between the internal volume of the container and the outside. from this container.
    When this passage is closed, the liquid contained in the container cannot escape from it. Any leakage of liquid from the interior to the exterior of the container is then prevented and the introduction of any external pollution (unwanted fluid or dust, for example) inside the container is avoided.
    When this passage is open, a sample of the liquid contained in the container can be taken.
    Such a solution is for example proposed in the document WO 2012/057843 (D1).
    However, this solution is not perfect.
    In fact, after a first use, the tap is closed and the upper part of the passage between the external volume and the internal volume of the container remains in contact with the external medium. This upper part of the passage can therefore be loaded with pollutants and in particular load with pollutants the liquid residues coming from inside the container. Also, during a subsequent opening of the sampling device, pollutants can then enter inside the container. Such pollutants can also be introduced into the container when the tap is open.
    For this purpose also, an alternative solution to the use of a tap is the use of an elastic valve generally produced with an elastomer.
    This is for example what is proposed in the US document
    425,465 (D2).
    The advantage of the elastic valve, compared to a tap, lies mainly in the absence of a zone for the passage of the liquid contained in the container in contact with the outside.
    However, such an elastic valve is stressed heavily and frequently so that its longevity can be altered, in particular compared to that of a tap.
    Furthermore, with this solution, maintaining a seal in all cases is difficult. Thus, for example, if the container is overturned, the liquid it contains applies pressure to the elastic valve and leaks can then be observed.
    There is therefore a need for a device for withdrawing a liquid from an improved container.
    To this end, the invention provides a device for withdrawing a liquid from a container, characterized in that it comprises:
    - a housing having a longitudinal axis;
    - a component comprising:
    • a body provided with at least one channel with a proximal end and a distal end;
    • a receptacle, fixed relative to the body, and located in the extension of the proximal end of said at least one channel, said component being rotatably mounted relative to the housing around the longitudinal axis of this housing between a closed position in which the distal end of said at least one channel is closed by the housing and an open position in which the distal end of said at least one channel is capable of establishing fluid communication with the container; and
    - an elastic valve housed in the receptacle.
    The device according to the invention may also include the following characteristics, taken alone or in combination:
    - The elastic valve has a central orifice, one distal end of which is in fluid communication with the proximal end of said at least one channel of the component and one proximal end of which is in the form of a plug provided with at least one slot;
    - The elastic valve is made of elastomer, for example silicone elastomer;
    - The component comprises a skirt, for example a cylindrical skirt, surrounding the receptacle;
    the body of the component comprises a housing as well as at least a second channel, a proximal end of which opens into the housing, which housing comprises an air filter in fluid communication with the outside, and of which a distal end is capable of establishing a fluid communication with the container;
    the component comprises another housing as well as at least a third channel, a proximal end of which opens into this other housing, which other housing comprises another air filter in fluid communication with the outside, and of which a distal end is suitable for establishing fluid communication with the container;
    - the distal end of said at least one third channel opens into the housing;
    - the or each air filter is hydrophobic and advantageously lipophobic;
    the or each air filter has orifices the largest dimension of which is less than or equal to 0.22 μm;
    - The housing includes a shutter to close the distal end of said at least one second channel and / or said at least one third channel when the component is in its closed position;
    - The device includes a witness of the closed or open position of the component;
    - The device further comprises a cap removably mounted on the housing;
    - The device includes a tamper indicator of the cap relative to the housing;
    - The housing includes a first base intended to be mounted on the outside of the container; and a second base intended to be mounted on the interior of the container, said second base, integrally formed or cooperating with the first base, forming the part of the housing with which the component cooperates to pass from its closed position to its position d 'opening and vice versa.
    The invention also relates to a container comprising a liquid and an opening, said container being characterized in that it comprises, at its opening, a liquid withdrawal device according to the invention.
    The container may include a dip tube connected to the distal end of the body.
    Finally, the invention also relates to the use of a container in accordance with the invention, as packaging for a liquid consisting of a sterile pharmaceutical composition.
    The invention will be described more precisely with reference to the appended figures, given without implied limitation:
    - Figure 1, which includes Figures 1 (a) to 1 (g), shows a first embodiment of a device according to the invention;
    - Figure 2, which includes Figures 2 (a) and 2 (b), shows a second embodiment of the invention;
    - Figure 3, which includes Figures 3 (a) to 3 (d), shows a third embodiment of the invention;
    - Figure 4, which includes Figures 4 (a) and 4 (b), shows a possible embodiment for an opening / closing state indicator of the device according to the invention;
    - Figure 5 is an alternative embodiment in which a dip tube is shown.
    Figure 1 shows a first embodiment of the invention.
    In general, the device 100 for withdrawing a liquid from a container according to the invention comprises a housing 10, a component 20 located in the housing 10, an elastic valve 30 and a cap 40 removably mounted on the housing 10 All these components are represented in the general view, produced from a cut perspective, of FIG. 1 (a).
    The housing 10 comprises a first base 11 intended to be mounted on the outside of the container and a second base 12 intended to be mounted on the inside of the container. The first base 11 is shown in a sectional view in Figure 1 (b) and the second base 12 is shown in a sectional view in Figure 1 (c). The bases 11 and 12 are mounted one on top of the other, according to a mounting which is preferably irremovable and without any relative movement being possible between them. A more detailed view of a zone for fixing the two bases 11, 12 to each other and to a container R is shown in the sectional view of FIG. 1 (d). In this assembly, elements 111 of the hook type of the first base are for example implemented to cooperate with an annular edge 122 of the second base 12. The assembly is carried out to ensure a very good seal between the two bases 11, 12 so that the risks of liquid leakage or introduction of pollutants (such as liquids, dust or pollutants such as bacteria) between the two bases are limited. It should be noted that the second base 12 also comprises a central orifice 123 which makes it possible to receive part of the component 20 and an upper wall 12SUP on which the component 20 comes to bear. As for the first base 11, it is hollow to be able to accommodate on the one hand the component 20 and on the other hand, in its lower part the second base 12.
    Advantageously, mounting on the container R requires an axial compression force F less than or equal to 300 N.
    Furthermore, the connection between the sampling device according to the invention and the container R is advantageously manually removable.
    The component 20 is rotatably mounted relative to the housing 10, that is to say both relative to the first base 11 and the second base 12 taking into account the fixing of the two bases 11,12 one by compared to each other. This rotation takes place between a so-called closed position and a so-called open position. This rotation takes place around the longitudinal axis AL of the housing 10. In practice, it is then advantageous to provide a rotation, between the closed position and the open position, around this longitudinal axis AL of 180 °.
    Component 20 is shown more precisely in Figure 1 (e). This component 20 is also shown in its closed position in Figure 1 (a).
    Component 20 comprises a body 26 provided with at least one channel 21 with a proximal end 21 p and a distal end 21 d. The channel 21 passes through the body 26 of the component 20.
    In the closed position (Figure 1 (a)), the distal end 21d of said at least one channel 21 is closed by the housing 10 and more precisely by an internal wall 12PI of the second base 12, internal wall which delimits the channel central 123 of this second base 12.
    In the open position (not shown), the distal end d of said at least one channel 21 is capable of establishing fluid communication with the container. More precisely, when one rotates, from the closed position, the component 20 around the longitudinal axis AL of the housing 10, for example by 180 °, the distal end 21 d of said at least one channel 21 arrives then opposite a passage 120 of the second base 12 emerging, in this case towards the inside of a container when the device 100 is mounted on such a container R as shown in FIG. 1 (d ). The open position corresponds to this situation where the liquid can pass from the container to the channel 21 of the component 20, through the passage 120 of the second base 12.
    The component 20 also includes a receptacle 24 situated in the extension of the proximal end 21 p of said at least one channel 21. This receptacle 24 is fixed relative to the body 26, and more precisely mounted fixed on the body 26. For example, to fix the receptacle 24 securely on the body 26, a circumferential groove 260 can be provided, situated at the level of the upper wall 26SUP of the body 26, and capable of receiving, for example by snap-fastening, a corresponding wall of the receptacle 24.
    Another type of mounting between the body 26 and the receptacle 24 can be envisaged, the main thing being that this mounting, removable or not, allows a fixing preventing any relative movement between the body 26 and the receptacle 24.
    In this regard, it is therefore possible, as a variant, and so that the receptacle 24 is fixed relative to the body 26, to provide that the receptacle 24 and the body 26 are in one piece. This will not prevent the mounting of the elastic valve 30. In fact, because of its elasticity, the elastic valve 30 can be housed inside the part formed by the receptacle 24 and the body 26, via the orifice 240 of receptacle 24.
    Thus, the receptacle 24 makes it possible to house the elastic valve 30 within the component 20. More precisely, the elastic valve 30 is held between the body 26 and the walls of the receptacle 24.
    The elastic valve 30 has a complementary shape with the internal wall of the receptacle 24. It also bears against the body 26.
    This elastic valve 30 is advantageously made of elastomer, for example silicone elastomer.
    It comprises a central orifice 31 of which a distal end 31 d is in fluid communication with the proximal end 21 d of said at least one channel 21 of the component 20. This fluid communication between the channel 21 and the central orifice 31 is present whatever or the angular position of the component 20 relative to the housing 10.
    The central orifice 31 also has a proximal end 31 p which is in the form of a plug 33 provided with a slot 34. The slot 34 can be simple (straight) or complex (in the form of a circular arc or star for example). When the elastic valve 30 is not stressed by an external action (Luer or other type syringe), the slot 34 is closed and a seal is provided between the outside of the component 20 and the inside of the component 20. C ' is what is shown in Figures 1 (a), 1 (e) and 1 (f). On the contrary, when the elastic valve 30 is stressed by an external action, the latter deforms axially, namely along the longitudinal axis AL of the housing 10. This is what is shown in FIG. 1 (g). It is therefore understood that the elastic valve 30 is not fixed to the internal wall of the receptacle 24.
    Moreover, when it is desired to take a liquid from a container fitted with a device as shown in FIG. 1, one starts from a situation conforming to that of FIG. 1 (a). The cap 40 is removed from the housing 10 and more precisely from the first base 10.
    A Luer L is introduced into the component 20, which has the effect (FIG. 1 (g)) of compressing the elastic valve 30 axially and of opening the slit 34 of the plug 33 at the level of the proximal end 31 d of the channel central 31 of the elastic valve 30. It is therefore understood that the elastic valve is not fixed to the internal wall of the receptacle 24.
    Then, using the Luer L, the component 20 and the elastic valve 30 are rotated, both then engaged with the Luer L. This rotation takes place around the longitudinal axis AL of the housing 10. The longitudinal axis AL of the housing 10 then merges with the longitudinal axis of the Luer L as with that of the central channel 31 of the elastic valve 30. The component 20 then passes from its closed position to its open position. In practice, the component 20 and more precisely the wall 26INF of the body 26 then slides against the upper wall 12SUP of the second base 12 of the housing 10. In the open position, a passage then exists between the interior volume of the container and the Luer L. The liquid contained in the container can then be withdrawn by Luer L.
    Once the liquid has been drawn from the container, the user turns the Luer L in the other direction, always around the longitudinal axis AL of the housing 10, to go from the open position to the closed position of the component 20. Once the closed position has been reached, the user can remove the Luer L from component 20. The elastic valve 30, which then no longer undergoes external action, returns to its initial shape, namely that of FIG. 1 ( a), thus closing the slot 34 of the plug 33 in a sealed manner.
    The device 100 according to the invention provides a double seal on the liquid sampling path.
    The first seal is produced by a valve type system, in this case between the component 20 and the second base 20. The second seal is produced by an elastic valve 30 located above the valve type system.
    The elastic valve 30 limits or prevents any introduction of pollutants into the upper part of the component 20, during before or after use. Furthermore, the presence of a valve type system between the container and the elastic valve 30 limits the stress on the latter and also limits the presence of liquid in the channels 21 and 31.
    Furthermore, during storage upside down of a container R comprising the device for withdrawing a liquid according to the invention, the system in the closed tap position remains tight and no leakage of the composition contained in the container. 'is visible even at high temperature, typically 40 ° C.
    In addition, the fact of accommodating the elastic valve 30 in the component 20 makes it possible to implement a valve type system with which the rotation of the component 20 relative to the housing 10 takes place around the longitudinal axis AL of the housing 10 The component 20 can therefore rotate in the housing 10, without a significant space being present between the component and the housing 10, which makes it possible to limit the space requirement, in particular radial, of the device is therefore particularly suitable for a container. Furthermore, with this design, the Luer L can remain in the longitudinal axis of the housing 10, and therefore of the component 20 intended to rotate, without being hindered by the container R. In addition, the rotation of the Luer L around this axis longitudinal to achieve the opening or closing of the component 20 also causes the elastic valve 30 to rotate. It therefore does not undergo any other stresses than the axial deformation imparted by the Luer L.
    In use, it is nevertheless necessary to provide a certain torque in order to open the channel 21 and thus to connect a puncture or collection system with the content of the container. This should be easy while giving the user a feeling of connection. In order to avoid the risk of contamination, the connection with the container is advantageously made once the connection between the sampling device and the Luer L is ensured. Advantageously, the assembly effort of the Luer L on the sampling device according to the invention must be less than 27.5 N (for 5 sec) with an insertion torque less than 0.1 N.m. The opening of channel 21 is then carried out once the Luer L link is effective, the opening torque then being advantageously less than 0.35 N.m. Closing channel 21 advantageously requires a torque of less than 0.35 N.m. Advantageously, the disassembly effort of the Luer L must be less than 27.5 N (for 5 sec) with a torque necessary to remove the Luer L less than 0.1 N.m.
    The cap 40 has a complementary shape with the housing 10 and more precisely with the first base 11, for example to be able to be screwed or unscrewed (the elements 110 of Figure 1 (b) represent the threads of the first base 11 ).
    The fitting torque of the cap 40 must be sufficient to ensure the closure of the liquid sampling device. A normally constituted adult person can provide a tightening torque on the cap 40 of approximately 1.1 N.m. Thus and advantageously, the closure of the cap 40 is carried out for a torque of less than 1.1 N.m. Similarly, an opening torque on the cap of about 1.1 N.m. can be applied by a normally constituted adult person and advantageously the cap is removed for a torque of less than 1.1 N.m.
    The cap 40 may advantageously provide at least one tamper-evident indicator 41 of the cap 40 relative to the housing 10. The tamper-evident indicator 41 may be in the form of an annular strip connected by frangible bridges (not visible on the FIG. 1) at the first base 11 of the housing 10. The bridges are broken at the first opening of the cap 40.
    Advantageously, the effort necessary to tear the frangible bridges during the first opening of the cap, must be such that the system can be used by a normally constituted person. For example, for a container opening diameter R of 20 mm, the first opening torque of the system C is advantageously less than 1.2 N.m
    It should be noted that if it is advantageous to provide a cap 40, its presence is not compulsory.
    Figure 2 shows a second embodiment of the invention.
    This second embodiment incorporates the characteristics of the first embodiment. Also, compared to Figures 1 (a) to 1 (g), the same elements have the same references.
    ίο
    However, this second embodiment includes additional features.
    Indeed, in this second embodiment, the body 26 of the component 20 ’is modified and includes a second channel 22 and a housing 27 into which the second channel 22 opens. More specifically, the distal end 22d of the second channel 22 is capable of establishing fluid communication with the container and the proximal end 22p of this second channel 22 opens into the housing 27, the latter comprising an air filter 50 in fluid communication with outside air.
    This makes it possible to be able to balance the pressures between the internal volume of the container and the outside, in particular when drawing a liquid from the container. Indeed, by withdrawing liquid from the container, and in the absence of an air intake on the outside, a vacuum is gradually created which makes the withdrawal of additional liquid a little more difficult for the user. . This is mainly encountered when the container is rigid.
    The air intake avoids this type of problem.
    Furthermore, the air filter 50 makes it possible to filter the air taken from the outside to prevent it from polluting the liquid contained in the container, for example by adding dust or other contaminants liable to pollute the contents of the container, such as bacteria.
    Furthermore, it should be noted that the addition of this air intake, incorporating an air filter 50, does not modify, compared to the first embodiment, the size of the sampling device 100 ’.
    And when the component 20 ’is rotated, the air filter 50 which is located in the housing 27 defined in the body 26 of the component 20’ accompanies the rotational movement.
    According to a particularly advantageous embodiment, the air filter 50 is hydrophobic. This helps prevent water from entering the container, thereby protecting the contents from hydration. The air filter 50 can have different porosities and advantageously a porosity which allows the return to sterile air, when the pores (orifices) of the filter have a larger dimension less than or equal to 0.22 μm. In this way the sterility of the composition contained in the container R can be preserved. The air filter 50 can advantageously be hydrophobic and lipophobic (oleophobic). In this case, it makes it possible to limit or prevent the penetration and / or escape of both water and non-polar solvents such as lipids (fatty substances).
    Figure 3 shows a third embodiment of the invention.
    This third embodiment incorporates the characteristics of the second embodiment. Also, compared to Figures 1 (a) to 1 (g) and Figures 2 (a) and 2 (b), the same elements have the same references.
    Figure 3 (a) shows a sectional view of a 100 ”device for withdrawing liquid from a container, when the component 20 is in its closed position. Figure 3 (b) shows in a sectional view, this same device 100 ”, but when the component 20 is in its open position. Figure 3 (c) is a partial view, in section, taken at the level of the air filters 50, 51. Figure 3 (d) shows, in a perspective view, the component 20 ”.
    However, it includes additional features.
    Indeed, in this third embodiment, the body 26 of the component 20 "is modified and includes a third channel 23 as well as another housing 28 in which the third channel opens. The third channel 23 allows an additional air intake between the outside of the container towards the inside of the container through another air filter 51 which is housed in the housing 28.
    Advantageously, the proximal end 23p of this third channel 22 opens into the housing 28 comprising the other air filter 51 and the distal end 23d of this third channel 23, capable of establishing fluid communication with the container, opens into the housing 27 of the air filter 50. In this way, the outside air entering through the air filter 51 passes through the third channel 23, then through the second channel 22 before arriving in the container. This design avoids making a third channel 23 in the same way as that of the second channel 22 and therefore makes the best use of the space available in the body 26 of the component 20 ".
    Alternatively, a third channel 23 could however be provided which is completely independent of the second channel 22.
    Again, the other air filter 51 due to its insertion into a housing 28 of the 20 "component, follows the rotational movement of this 20" component.
    This additional air intake improves the speed of pressure balancing when withdrawing liquid from the container, in particular for rigid containers, without impacting the overall size of the 100 ”device.
    According to a particularly advantageous embodiment, the air filter 51 is hydrophobic. This helps prevent water from entering the container, thereby protecting the contents from hydration. The air filter 51 can have different porosities and advantageously a porosity which allows the return to sterile air, when the pores (orifices) of the filter have a larger dimension less than or equal to 0.22 μm. In this way the sterility of the composition contained in the container R can be preserved. The other air filter 51 can advantageously be hydrophobic and lipophobic (oleophobic). In this case, it makes it possible to limit or prevent the penetration and / or escape of both water and non-polar solvents such as lipids (fatty substances).
    An additional feature provided in the third embodiment concerns the addition of a shutter 121 of the air intake channel on the housing and more precisely on the second base 12 of this housing 10.
    In fact, the second base 12 includes a shutter 121 for the second channel 22. Thus, when the component 20 ”is in its closed position (FIG. 3 (a)), the second channel 22 is closed by this shutter 121, at the level of its distal end 22d. In this case, it is recalled that the distal end 21d of the channel 21 intended for the withdrawal of liquid is also closed by the internal wall 12PI of the second base 12, moreover, when the component 20 "is in its open position ( Figure 3 (b)), the second channel 22 is open at its distal end 22d. In this case, it is recalled that the distal end 21d of the channel 21 then opens into the passage 120 of the second base 12, a passage which opens inside the container R.
    The use of a shutter 121 provides additional security when the 20 ”component is in its closed position. In fact, if the container R is overturned, the liquid which cannot enter the closed channel 21 will also not be able to enter the second channel 22.
    Another additional feature provided in the third embodiment concerns the addition of a skirt 25, for example cylindrical, surrounding the receptacle 24. This skirt 25 can be made of the same material as the body 26 and therefore be molded at the same time. as long as the body 26. This skirt allows, as can be seen in FIG. 3 (b) to offer guidance for a Luer L. Indeed, the Luer L can thus be guided in the space defined between the receptacle 24 and the skirt 25. This facilitates the action of the user in particular by preventing misuse which would consist in applying the Luer L laterally, that is to say at an angle to the longitudinal axis (AL).
    Furthermore, the presence of this skirt 25 can allow a user to ensure an opening or closing action of the component 20 manually and directly, namely without the intermediary of a syringe of the type
    Luer or other, by manipulating the skirt 25 without touching the receptacle 24 or the plug 33. As a result, this actuation can be carried out without the user touching the elements likely to be in contact with the liquid contained in the container. This ensures the cleanliness and / or sterility of the plug 33.
    It should be noted that the invention is not limited to the three embodiments shown in the appended figures.
    The invention indeed covers other embodiments.
    Thus, the skirt 25 of the component 20 ”surrounding the housing 24 for the elastic valve 30, discussed in support of the third embodiment, can be added to the embodiment shown in Figure 1 or to that shown in the figure 2. Indeed, the function fulfilled by the skirt 25 is also of interest in these cases.
    Thus also, the arrangement of the housing 10 making it possible to close concomitantly on the one hand, the channel 21 of the component 20 ”, provided for the flow of the liquid contained in the container and on the other hand, the intake channel 22 component air 20 ”by a shutter, as discussed in support of the third embodiment, can also be provided for a modified embodiment of FIG. 2. In fact, the presence of a shutter 121 brings a benefit as soon as '' an air intake is envisaged.
    Whatever the embodiment envisaged, an indicator of the state of the component 20, 20 ’, 20” can be provided, open or closed. For this, it suffices to provide at least one opening O on the first base 11 making it possible to see, through this opening, a part of the component 20 comprising a visual indicator TV of its state.
    This is what is shown in Figure 4, where Figure 4 (a) shows the closed position of the component 20, 20 ', 20 ”(red TV visual indicator for example) and Figure 4 (b) its position opening (green TV visual indicator for example).
    This provides additional security for the user.
    It is advantageous to also provide, on the first base 11, at least one barbican or an opening, laterally with respect to the opening O, in order to allow the evacuation of liquids possibly collected behind the first base 11. In fact, it has been found that when liquid is trapped behind the first base 11, its evaporation can bring, in contact with the filter or filters, residues capable of reducing the effectiveness of the filters for balancing the pressures between the interior and the outside of container R. The evacuation of liquids is increased thanks to the presence of barbacans and the risk of degrading the quality of the filters is reduced.
    Different materials can be envisaged to make the different elements of the device 100, 100 ’, 100” according to the invention.
    The first base 11 of the housing 10 may be made of Acrilonitrile Butadiene Styrene (ABS), polycarbonate (PC) or poly (butylene terephthalate) (PBT). The second base 12 of the housing 10 and the elastic valve 30 can be made of elastomeric thermoplastic (TPE), vulcanized elastomeric thermoplastic (TPV), thermoplastic urethane elastomer (TPU), silicone, fluorosilicone, chlorobutyl, bromobutyl, nitrile, fluoroelastomer (FKM) or ethylene-propylene-diene monomer (EPDM). Advantageously, these elastomers can be coated with a protective film.
    Component 20, 20 ', 20 ”(therefore the body 26, the receptacle 24 and, where appropriate, the skirt 25) can be made of poly (butylene terephthalate) (PBT), Polypropylene (PP) or Polyethylene Terephthalate (PET).
    The cap 40 may in particular be made of polypropylene (HP).
    These materials can be sterilized by conventional means. Advantageously, they can be irradiated or autoclaved.
    It should be noted that in the above description, the housing 10 is presented as being formed of two bases 11, 12 mounted one on the other. In the context of the invention, provision could be made for the housing 10 to be made in one piece, a first part fulfilling the function of the first base 11 and a second part fulfilling the function of the second base 12. It is possible, for example, consider the use of a crimped, clipped or screwed cap on the opening of container R. Advantageously, the device 100, 100 ′, 100 ″ of liquid collection according to the invention is non-removable in order to '' ensure the safety of children vis-à-vis the composition contained in the container R or to guarantee that the content has not been modified.
    The invention also relates to a container R comprising a liquid (solution or suspension) and an opening, said container R comprising, at its opening, a device 100, 100 ’, 100” for withdrawing liquid according to the invention. According to one embodiment, the container R comprises a dip tube TP, flexible or rigid, in connection with the distal end 21 d of the body 26. Advantageously the dip tube TP has a length corresponding to the height of the container R, which allows the withdrawal of the composition contained in the container R, head up. The dip tube TP is for example shown in Figure 5. This Figure 5 actually corresponds to Figure 3 (a), to which the dip tube TP has been added. Of course, such a dip tube can be envisaged regardless of the embodiment considered.
    The container R can be a bottle, a vial or a pocket.
    The container R can be flexible or rigid. The material of which the container R is made can advantageously be glass or plastic (different types of plastic can be envisaged).
    Finally, the invention also relates to the use of a container R 10 comprising a liquid and provided with an opening and comprising, at the level of its opening, a device 100, 100 ′, 100 ″ for withdrawing liquid according to the invention as a packaging of a liquid consisting of a sterile pharmaceutical composition.
    The invention also relates to the use, within the framework of a curative or preventive therapeutic treatment, of a pharmaceutical composition contained in a container R comprising said pharmaceutical composition and an opening, said container R comprising, at the level of its opening, a device 100, 100 ′, 100 ”for withdrawing liquid according to the invention. According to a particularly preferred embodiment of the invention, said use takes place in the veterinary field for administering to an animal a sterile pharmaceutical composition.
    权利要求:
    Claims (17)
    [1" id="c-fr-0001]
    1. Device (100, 100 ’, 100”) for withdrawing a liquid from a container, characterized in that it comprises:
    - a housing (10) having a longitudinal axis (AL);
    - a component (20, 20 ’, 20”) comprising:
    • a body (26) provided with at least one channel (21) with a proximal end (21 p) and a distal end (21 d);
    • a receptacle (24), fixed relative to the body (26), and located in the extension of the proximal end (21 p) of said at least one channel (21), said component (20, 20 ', 20 ”) being rotatably mounted relative to the housing (10) about the longitudinal axis of this housing (10) between a closed position in which the distal end (21 d) of said at least one channel (21) is closed by the housing (10) and an open position in which the distal end (21 d) of said at least one channel (21) is capable of establishing fluid communication with the container; and
    - an elastic valve (30) housed in the receptacle (24).
    [2" id="c-fr-0002]
    2. Device (100, 100 ', 100 ”) according to claim 1, characterized in that the elastic valve (30) has a central orifice (31) of which a distal end (31 d) is in fluid communication with the end proximal (21 d) of said at least one channel (21) of the component (20) and one proximal end (31 p) of which is in the form of a plug (33) provided with at least one slot (34).
    [3" id="c-fr-0003]
    3. Device (100, 100 ’, 100”) according to one of the preceding claims, characterized in that the elastic valve (30) is made of elastomer, for example silicone elastomer.
    [4" id="c-fr-0004]
    4. Device (100, 100 ’, 100”) according to one of the preceding claims, characterized in that the component (20) comprises a skirt (25), for example a cylindrical skirt, surrounding the receptacle (24).
    [5" id="c-fr-0005]
    5. Device (100, 100 ', 100 ”) according to one of the preceding claims, characterized in that the body (26) of the component (20', 20”) comprises a housing (27) as well as at least one second channel (22), one proximal end (22p) of which opens into the housing (27), which housing (27) comprises an air filter (50) in fluid communication with the outside, and one distal end (22d) of which is suitable for establishing fluid communication with the container.
    [6" id="c-fr-0006]
    6. Device (100, 100 ', 100 ”) according to claim 5, characterized in that the component (20”) comprises another housing (28) as well as at least a third channel (23) including a proximal end ( 23p) opens into this other housing (28), which other housing (28) comprises another air filter (51) in fluid communication with the outside, and one distal end (23d) of which is capable of establishing fluid communication with the recipient.
    [7" id="c-fr-0007]
    7. Device (100, 100 ’, 100”) according to the preceding claim, characterized in that the distal end (23d) of said at least one third channel (23) opens into the housing (27).
    [8" id="c-fr-0008]
    8. Device (100, 100 ’, 100”) according to one of claims 5 to 7, characterized in that the or each air filter (50, 51) is hydrophobic and advantageously lipophobic.
    [9" id="c-fr-0009]
    9. Device (100, 100 ', 100 ”) according to one of claims 5 to 8, characterized in that the or each air filter (50, 51) has orifices the largest dimension of which is less than or equal to 0.22 pm.
    [10" id="c-fr-0010]
    10. Device (100, 100 ', 100 ”) according to one of claims 5 to 9, characterized in that the housing (10) comprises a shutter (120) for closing the distal end (22d, 23d) of said au at least one second channel (22) and / or said at least one third channel (23) when the component (20) is in its closed position.
    [11" id="c-fr-0011]
    11. Device (100, 100 ’, 100”) according to one of the preceding claims, characterized in that it comprises a tell-tale (T) of the closed or open position of the component (20).
    [12" id="c-fr-0012]
    12. Device (100, 100 ’, 100”) according to one of the preceding claims, characterized in that it further comprises a cap (40) removably mounted on the housing (10).
    [13" id="c-fr-0013]
    13. Device (100, 100 ’, 100”) according to the preceding claim, characterized in that it comprises a tamper indicator (41) of the cap (40) relative to the housing (10).
    5
    [14" id="c-fr-0014]
    14. Device (100, 100 ’, 100”) according to one of the preceding claims, characterized in that the housing (10) comprises:
    - a first base (11) intended to be mounted on the outside of the container; and
    - a second base (12) intended to be mounted on the interior of the container, said second base (12), made in one piece or cooperating with the first base
    10 (11), forming the part of the housing (10) with which the component (20) cooperates to pass from its closed position to its open position and vice versa.
    [15" id="c-fr-0015]
    15. Container (R) comprising a liquid and an opening, said container being characterized in that it comprises, at its opening, a device (100,
    15 100 ’, 100”) of liquid sample according to one of the preceding claims.
    [16" id="c-fr-0016]
    16. Container (R) according to claim 15, said container comprising a dip tube in connection with the distal end (21 d) of the body (26).
    [17" id="c-fr-0017]
    17. Use of a container (R) according to one of claims 15 or 16, as a packaging for a liquid consisting of a sterile pharmaceutical composition.
    1/7
    2/7
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    同族专利:
    公开号 | 公开日
    EP3554451B1|2020-11-11|
    AU2017378199A1|2019-07-18|
    US20200038290A1|2020-02-06|
    EP3554451A1|2019-10-23|
    WO2018109215A1|2018-06-21|
    KR20190002569U|2019-10-14|
    CN110446481B|2022-01-11|
    ES2835298T3|2021-06-22|
    FR3060305B1|2019-05-24|
    SI3554451T1|2021-08-31|
    JP2020514194A|2020-05-21|
    CN110446481A|2019-11-12|
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    GB2578705B|2013-08-07|2020-11-11|West Pharmaceutical Services Il Ltd|Liquid transfer devices for use with infusion liquid containers|FR3080368B1|2018-04-20|2021-04-23|Virbac|SHOCK PROTECTION DEVICE SUITABLE TO EQUIP A BOTTLE|
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    法律状态:
    2017-10-24| PLFP| Fee payment|Year of fee payment: 2 |
    2018-06-22| PLSC| Publication of the preliminary search report|Effective date: 20180622 |
    2018-09-25| PLFP| Fee payment|Year of fee payment: 3 |
    2019-11-20| PLFP| Fee payment|Year of fee payment: 4 |
    2020-11-20| PLFP| Fee payment|Year of fee payment: 5 |
    2021-11-17| PLFP| Fee payment|Year of fee payment: 6 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1662671A|FR3060305B1|2016-12-16|2016-12-16|DEVICE FOR COLLECTING A LIQUID CONTAINED IN A CONTAINER, CONTAINER AND USE THEREOF.|
    FR1662671|2016-12-16|FR1662671A| FR3060305B1|2016-12-16|2016-12-16|DEVICE FOR COLLECTING A LIQUID CONTAINED IN A CONTAINER, CONTAINER AND USE THEREOF.|
    US16/468,980| US20200038290A1|2016-12-16|2017-12-15|Device for collecting a sample of a liquid contained in a container, associated container, and use of this container|
    KR2020197000054U| KR20190002569U|2016-12-16|2017-12-15|Apparatus, associated containers and uses for collecting the samples of liquid in the containers|
    SI201730512T| SI3554451T1|2016-12-16|2017-12-15|Device for collecting a sample of a liquid contained in a container, associated container, and use of this container|
    AU2017378199A| AU2017378199A1|2016-12-16|2017-12-15|Device for collecting a sample of a liquid contained in a container, associated container, and use of this container|
    CN201780081963.0A| CN110446481B|2016-12-16|2017-12-15|Device for sampling a liquid contained in a container, associated container and use of the container|
    ES17825480T| ES2835298T3|2016-12-16|2017-12-15|Device for the extraction of a liquid contained in a container, related container and use of this container|
    EP17825480.1A| EP3554451B1|2016-12-16|2017-12-15|Device for collecting a sample of a liquid contained in a container, associated container, and use of this container|
    JP2019532026A| JP2020514194A|2016-12-16|2017-12-15|Device for collecting a sample of liquid contained in a container, associated container, and use of this container|
    PCT/EP2017/083162| WO2018109215A1|2016-12-16|2017-12-15|Device for collecting a sample of a liquid contained in a container, associated container, and use of this container|
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