• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    A concentrate based on olive oil and a topical application for skin care comprising said concentrate. A concentrate based on olive oil to be used as an active ingredient in a topical application for skin care comprising olive oil, with an ORAC factor of at least 8 (μmol equivalent Trolox/g), enriched with at least one extract from the olive fruit rich in maslinic acid and with at least one extract also from the fruit or olive leaf rich in Hydroxytyrosol. The invention also relates to a topical preparation for skin care comprising between 1% and 3% by weight of the concentrate. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2756898A1
    申请号:ES201831041
    申请日:2018-10-26
    公开日:2020-04-27
    发明作者:Monjo Elena Grau
    申请人:E Grau Active Cosmetics S L U；
    IPC主号:
    专利说明:

    [0001]
    [0002] A concentrate based on olive oil and a preparation for topical application for skin care that includes said concentrate
    [0003]
    [0004] Technical sector of the invention
    [0005] The invention relates to the field of concentrates that are used as active ingredients for the preparation of topical creams or the like for skin care or to prevent or treat skin or dermatological diseases.
    [0006]
    [0007] Background of the Invention
    [0008] The properties of olive oil in maintaining skin integrity are well documented today. The practice of including olive oil in the formulation of creams, lotions and body milks is not something new, for example, to hydrate the skin and avoid the appearance of wrinkles; to polish hair and even as a base for therapeutic massages.
    [0009]
    [0010] On the one hand, it is known that olive oil is an antioxidant product in itself, and its role in reducing oxidative stress has been demonstrated, which makes it an interesting product in the field of cosmetics to strengthen skin function as a barrier and to reduce transepidermal water loss, improving the hydrolipidic mantle and the hydration levels of the skin.
    [0011]
    [0012] The antioxidant vitamins that olive oil possesses, mainly Vitamin E, play an important role in this decrease in oxidative stress because they help fix free radicals (unstable molecules that, for different reasons such as exposure to the sun or pollution environmental, they lack an electron destabilizing and creating reactions that can damage the cell membrane), contributing to delay skin aging.
    [0013]
    [0014] On the other hand, the antioxidant effect of 3,3-dihydroxyphenyl ethanol, hereinafter referred to as Hydroxytyrosol, is also well documented. To take advantage of this antioxidant action, Hydroxytyrosol extracts are ingredients used in the field of cosmetics. For example, the Hydroxytyrosol extract is a very useful product in the formulation of sunscreens since, due to its exclusive properties, it is one of the ingredients with greater capacity to combat sun damage on the skin.
    [0015]
    [0016] It is the case that the Hydroxytyrosol is a component, although a minority, of the aqueous fraction of the olive, present in the extra virgin olive oil (AOV) but not in the rest of the oils since it is eliminated with refining. To obtain high purity extracts of Hydroxytyrosol there are different documented methods, more or less complex. Currently, there are numerous suppliers of Hydroxytyrosol concentrates on the market.
    [0017]
    [0018] 2-alpha, 3-betadihydroxy-28-carboxyioleannan, hereinafter referred to as maslinic acid, is an acid not too naturally present, having been detected in several plants. Its antihistamine and anti-inflammatory effect is well documented. It is possible to obtain extracts of malic acid from waste products from the milling of the olive, especially from the waxes of the surface of the fruit of the European Olea, obtaining high yields and a high purity of the resulting concentrates.
    [0019]
    [0020] To take advantage of the properties of Masilic Acid, for example, the cosmetic use of Maslinic Acid, a salt thereof, a derivative thereof, or a mixture thereof, is known for skin redensification as well as dermocosmetic compositions for skin redensification comprising maslinic acid. Examples of cosmetic uses of maslinic acid are described in EP 1295587 and ES 2462565.
    [0021]
    [0022] Transepidermal water loss, to which we have previously referred, also called TEWL - by Transepidermal Water Loss- is defined as the amount of water that passes from the interior of the body to the atmosphere through diffusion and / or evaporation processes. It is an essential concept when you think about skin dryness and it is an index that is used to evaluate the reparative capacity in the skin of cosmetic products.
    [0023]
    [0024] An objective of the present invention is a concentrate suitable for use as an active ingredient in a topically applied preparation for skin care, especially with a strong antioxidant action on the skin, at least sufficiently to be used for the repair of aggressions, for the improvement of the hydrolipidic mantle or for the immediate and long-term hydration of the skin.
    [0025]
    [0026] On the other hand, this strong antioxidant action is also of interest for the preservation of the properties of the preparation, that is to prevent its deterioration by oxidation of acids unsaturated fats, for example due to excessive contact of the preparation with air (especially when the bottles are not closed after use) or by subjecting the preparation to heat or light (which is conventionally expected using colored or opaque bottles).
    [0027]
    [0028] Explanation of the invention
    [0029] The inventors of the present invention have surprisingly revealed that the antioxidant effect that was attributed in particular to Vitamin E in olive oil is enhanced in a non-deductible way by Hydroxytyrosol, when it is added to olive oil in amounts not present in naturally in the olive oil itself. This effect is not only not affected by the presence of maslinic acid in an unnatural proportion in olive oil, but it does not prevent said maslinic acid from displaying its properties, for example, anti-inflammatory.
    [0030]
    [0031] For this reason, according to claim 1, the invention refers to a concentrate based on olive oil to be used as an active ingredient in a topical preparation for skin care that comprises olive oil with an ORAC factor. of at least 8 (^ mol equivalent Trolox / g) that is enriched with at least one extract from the olive fruit rich in maslinic acid; and with at least one extract also from the fruit or olive leaf rich in Hydroxytyrosol.
    [0032]
    [0033] The ORAC is a scale of values on which the degree of antioxidant effect of a sample is recorded numerically by a value measured in micromoles of Trolox equivalents (a standard of measurement) per unit weight of the sample. The higher the value assigned in this index to a sample, the greater its antioxidant power.
    [0034]
    [0035] This value system, which translated from English means Oxygen Radical Absorbance Capacity, was developed by Tufts University, USA, in order to provide a fast and reliable means to know how beneficial a product can be to face the oxidative stress problem or oxidation process, possessing an error margin of / - 5%.
    [0036]
    [0037] For this case, the ORAC values of the assays to which we will refer later were obtained by spectrofluorescence and the fluorescence readings were performed on a Synergy ™ H1M model spectrofluorimeter, Hybrid Multi-Mode microplate Reader (BioTek Instruments, Inc., Winooski, VT, USA).
    [0038] This concentrate from olive oil enriched with Hydroxytyrosol and maslinic acid displays an effect on skin care, especially with a strong antioxidant action on the skin, of great interest for the repair of aggressions, for the improvement of the hydrolipidic mantle or for immediate and long-term hydration of the skin. The concentrate of the invention can therefore be used, among other purposes, to strengthen the skin's immune system; for wrinkle reduction; to provide greater luminosity and a more homogeneous tone to the skin; for the acceleration of the healing processes and / or for the improvement of post-scar marks.
    [0039]
    [0040] Advantageously, the aforementioned moisturizing properties have also been shown to be especially effective for sensitive skin (dry, reactive, sensitized or uncomfortable skin), as demonstrated below.
    [0041]
    [0042] The aforementioned effects are also appreciable at small doses. Then, in a variant of the invention, the amount of malic acid present in the concentrate amounts to at least 0.040% by weight of the concentrate; and the amount of Hydroxytyrosol in the concentrate represents at least 0.010% by weight of the concentrate. Preferably, the amount of malic acid present in the concentrate is from 0.045% to 1% by weight of the concentrate; and the amount of Hydroxytyrosol in the concentrate is from 0.010% to 2% by weight of the concentrate and more preferably between 0.020% and 1% by weight of the concentrate.
    [0043]
    [0044] According to a variant of the invention, the extract rich in Hydroxytyrosol has a richness of at least 20% in Hydroxytyrosol.
    [0045]
    [0046] According to a variant of the invention, the extract rich in maslinic acid has a richness of at least 60% in maslinic acid, preferably between 60% to 85%.
    [0047]
    [0048] It is also the case that the remarkable multiplying effect of the antioxidant properties of olive oil is such that the invention allows the formulation of dermocosmetic preparations, for example, in the form of creams, in which the concentrate of the invention is the active ingredient with a presence of only between 1% and 4%, and preferably between 1% and 3%, by weight of the preparation.
    [0049]
    [0050] The present invention therefore also relates to a dermocosmetic preparation with these characteristics, comprising between 1% and 3% by weight of the concentrate based on olive oil enriched with Hydroxytyrosol and maslinic acid.
    [0051]
    [0052] Advantageously, the effectiveness of the concentrate discloses an alternative for topically applied formulations and preparations that employ synthetic antioxidants such as butylated hydroxytoluene (BHT). The concentrate of the invention thus contributes to obtaining more natural, more related preparations for use on human skin and again especially for sensitive skin.
    [0053]
    [0054] Last but not least, since concentrate is a product obtained from the olive, the present invention offers a new incentive for this sector to remain one of the most dynamic in the Spanish agri-food system, which, in fact, acts as one of the fundamental engines of the Spanish economy.
    [0055]
    [0056] Brief description of the drawings
    [0057] Fig. 1 shows the antioxidant capacities of a concentrate according to the invention;
    [0058] Fig. 2 shows from which order the enhancing effect of the antioxidant properties of olive oil is evident in a concentrate according to the invention;
    [0059] Figs. 3 and 4, illustrate the effectiveness of a concentrate according to the invention, as well as a preparation that comprises only 2% by weight of the concentrate as an active ingredient, in repairing the skin that is reflected in improving its Erythema index and on improving their TEWL index, respectively;
    [0060] Figs. 5 and 6 illustrate the hydration kinetics of normal skin and sensitive skin, respectively, of respective dermocosmetic preparations comprising 1% and 2% by weight of a concentrate based on olive oil according to the invention.
    [0061]
    [0062] Detailed explanation of the invention
    [0063] The surprisingly enhancing effect of the antioxidant properties of an additive olive oil according to the present invention is made plausible in the following concentrate, which exemplifies the invention.
    [0064]
    [0065]
    [0066]
    [0067] (1) Extra virgin olive oil (Empeltre variety)
    [0068] (2) Extract from the fruit of the olive tree with purity of 60% in Maslinic acid.
    [0069] (3) Extract from the olive leaf with 20% purity in Hydroxytyrosol.
    [0070]
    [0071] Table 1 : Formulation of a concentrate according to a variant of the invention.
    [0072]
    [0073] The concentrate is obtained by adding a starting oil rich in Vitamin E and with a high antioxidant power with 850 ppm of OA MA 75 and 1,250 ppm of OA HT ECO 20%, therefore resulting in the total concentration, in the concentrate obtained , of:
    [0074] • 510 ppm of maslinic acid
    [0075] • 250 ppm of Hydroxytyrosol
    [0076]
    [0077] Table 2 below compares the antioxidant capacity on the ORAC scale of various olive oils, including the olive oil selected to obtain the concentrate. Note that the ORAC value of the concentrate is 10 times higher than that of the aforementioned starting oil, which reveals an unexpected increase in antioxidant capacity taking into account that the presence of Hydroxytyrosol (by way of adding) is only 250 ppm. That is, with very little addition of Hydroxytyrosol the antioxidant capacity of the starting oil is multiplied significantly, having selected a starting oil with an ORAC value greater than 8 and in this case specifically with an ORAC value of 9.56 ± 0.70.
    [0078]
    [0079]
    [0080]
    [0081]
    [0082] Table 2 : Significant increase in the ORAC value of olive oil rich in Vitamin E with a small addition of extract rich in Hydroxytyrosol.
    [0083] The enhancing effect of the antioxidant properties of the starting olive oil can also be corroborated by comparing the antioxidant capacity of the same neutral medium that it incorporates, in equal concentrations (100 ppm): in a first case, olive oil (which provides only the intrinsic antioxidant properties) of the mentioned olive oil); in a second case a synthetic antioxidant, specifically butylated hydroxytoluene (BHT); and in a third case, a concentrate according to the invention (in the version of Table 1), respectively.
    [0084]
    [0085] Fig. 1 shows this comparative test in which the antioxidant capacity has been measured in equivalent Trolox, at the same concentrations (100 ppm).
    [0086]
    [0087] See that the antioxidant potential is greater in the third case, that is in the neutral medium that incorporates a concentrate according to the invention.
    [0088]
    [0089] The incidence of the concentration of the ingredients that unnaturally contribute Hydroxytyrosol to the neutral media of Fig. 1 is shown in Fig. 2, the antioxidant potential having been measured for different concentrations.
    [0090]
    [0091] These tests show that the enhancing effect of the antioxidant properties of the olive oil added to obtain a concentrate according to the invention are seen for small concentrations, in particular from concentrations of 50 ppm of the concentrate in the medium. From these concentrations the antioxidant potential of the medium incorporated in the concentrate is even greater than that resulting from directly adding the medium with butylated hydroxytoluene (BHT).
    [0092]
    [0093] The efficacy, in terms of skin care, of this enhancing effect in a concentrate according to the invention, as well as of a dermocosmetic preparation comprising said concentrate, is revealed in in vivo tests.
    [0094]
    [0095] The efficacy is contrasted by testing the effect that the concentrate displays in a dermocosmetic preparation, using for this the repair / anti-inflammatory indices in Erythema and TEWL repair, as shown in Table 4.
    [0096]
    [0097] Specifically, the effect of the same placebo cream to which Hydroxytyrosol is incorporated in different ways is tested: in a first case, in a second case. Carried encapsulated in a LD (-Liphosome Device- in the form of a vesicle composed mainly of naturally occurring phospholipids organized in bilayers in which the active is integrated into the nucleus to facilitate the formulation and bioavailability of the active in the skin); and in a third case in which Hydroxytyrosol is incorporated via the concentrate, that is, as an additive in olive oil with a high ORAC index. Naturally, it is ensured that the placebo cream does not contain ingredients that can plausibly increase or contribute to the repair effect of the skin. The placebo cream formulation used is as shown in Table 3.
    [0098]
    [0099]
    [0100]
    [0101]
    [0102] Table 3 : Composition of the placebo cream used in the repair tests.
    [0103]
    [0104] in repair HT repair vs Efficacy prepared prepared ERITEMA TEWL contained in (Index / HT content
    [0105]
    [0106]
    [0107]
    [0108]
    [0109] (1) Efficacy tested at 30 'of application
    [0110] (2) Efficacy tested at 30 'of application
    [0111] (3) By way of extract with a minimum content of Maslinic acid of 60%.
    [0112] (4) By way of extract with a minimum content of Hydroxytyrosol of 20%.
    [0113]
    [0114] Table 4 : In vivo tests of dermoscosmetic preparations added with Hydroxytyrosol alone or via the concentration according to the invention based on olive oil with a high ORAC index.
    [0115]
    [0116] From the results shown in Table 4, it appears that a similar repairing effect is achieved with the dermocosmetic preparation according to the invention with 160 times lower concentrations of Hydroxytyrosol than with dermoscosmetic preparations added in isolation with Hydroxytyrosol extract, that is, not via the concentrate based on olive oil with a high ORAC index.
    [0117]
    [0118] The repairing effect is even greater at eight times lower concentrations of Hydroxytyrosol in the dermocosmetic preparation according to the invention compared to a dermocosmetic preparation added alone with encapsulated Hydroxytyrosol or LD (which is one of the preferred ways in the industry to facilitate formulation and the bioavailability of an asset in the skin).
    [0119]
    [0120] From the point of view of efficacy, Table 4 (see Efficacy column) reveals how the repair rates of Erythema and TEWL per molecule of HT (Hydroxytyrosol) are both of the order of ten times higher in the case of the preparation that incorporates the concentrate of the invention with respect to the preparation added with HT 40% encapsulated in an LD, which is, as noted above, a commonly preferred way to prolong the bioavailability of the active ingredient , that is, Hydroxytyrosol, improving its absorption, penetration and diffusion in the skin. In other words, a cream that incorporates the concentrate of the invention has a proven effectiveness ten times higher than this same cream added with the same amounts of Hydroxytyrosol, even when it is transported encapsulated in a LD.
    [0121]
    [0122] Figs. 3 and 4 graphically illustrate this effectiveness in incorporating the concentrate as an active ingredient in a dermoscosmetic preparation according to Table 4, that is in a concentration of 2%.
    [0123]
    [0124] Thus, Fig. 3 shows the repair rate in Erythema of a dermocosmetic preparation in the form of a cream with 2% of the concentrate and Fig. 4 shows the repair index TEWL of the same dermocosmetic preparation, in both cases in comparison with the placebo cream and with the 100% concentrate.
    [0125]
    [0126] In order to assess the repair power of the above mentioned formulations, skin stress (Erythema) has been induced by light photoirritation (UV radiation). After 24 hours of stress induction, the different formulations have been applied in the specific areas. More specifically, skin irritation was induced with ultraviolet radiation corresponding to 1.5 times the MED (minimum erythematous dose), previously calculated for each subject (a total of 20 subjects). The minimum dose that produces an evident Erythema is called the "minimum erythematous dose" or MED and can be evaluated visually by experts or instrumentally. A typical exposure time to produce Erythema on unprotected skin is 2 minutes. The ultraviolet radiation was obtained from a 300W xenon lamp, model Multiport Solar UV Simulator model 601 connected to a precision power supply, model XPS400 (Solar Light Co. Inc. Philadelphia, USA). The spectral output follows the distribution of sunlight from 290nm to 400nm.
    [0127]
    [0128] The repair rate in Erythema was measured with MEXAMETER®MX 18. These measurements are based on the absorption principle. A receiver measures the light reflected from the skin so that the amount of light absorbed by the skin can be calculated.
    [0129]
    [0130] TEWL repair index was measured with TEWAMETER® TM300. This measurement indicates the trans epidermal water loss (TEWL) and the method measures the vapor tension gradient between two electrodes located at different distances from the skin surface.
    [0131]
    [0132] The readings were taken in the moments:
    [0133] • A [t0] (baseline value): before slight irritation of light (UV exposure).
    [0134] • A [T0 ']: 24 hours after stress induction (UV exposure) and before the products are used.
    [0135] • A [T30min]: after 30 minutes of applying the products in the specific area.
    [0136] • A [T4h]: after 4 hours from the application of the products in the specific area.
    [0137]
    [0138] Repair rates are calculated using the following expressions:
    [0139] Repair rate at 30 'TEWL (IRt30) = 1 - (T30'-t0) / (T0'-t0)
    [0140] Repair rate at 30 'Erythema (IRe30) = 1 - (T30'-t0) / (T0'-t0)
    [0141] Average IR30 = (IRt30 IRe30) / 2
    [0142] Repair rate at 4h TEWL (IRe4h) = 1 - (T4H-t0) / (T0'-t0)
    [0143] Repair rate a
    [0144] 4h Erythema (IRe4h) = 1 - (T4H-t0) / (T0'-t0)
    [0145] Average IR4h = (IRt4h IRe4h) / 2
    [0146]
    [0147] From Figs. 3 and 4, it is again inferred not only the efficacy of the concentrate but how it can display its practical effect in small doses, which is undoubtedly of interest to optimize the formulations of the dermocosmetic preparations that will include the concentrate (remember that a cream that incorporates only 2% by weight of the concentrate of the invention has a proven efficiency ten times higher than this same cream added with the same amounts of an extract of Hydroxytyrosol, even when it is encapsulated in an LD).
    [0148]
    [0149] It is worth repairing the anti-inflammatory effect of both the concentrate and the cream that the concentrate incorporates, indicating that the properties provided by the maslinic acid added in the concentrate are not impaired, neither by combination with the Hydroxytyrosol also added in the concentrate, nor with the rest of the ingredients of the dermocosmetic preparation when the concentrate is used as its active ingredient.
    [0150] Regarding hydration kinetics, several versions of the dermocosmetic preparation were tested, in the form of the placebo cream and the same placebo cream as the base, and with concentrations of 1% and 2% of the concentrate in Table 3. The formulations for the kinetic test are shown in Table 5.
    [0151]
    [0152]
    [0153]
    [0154]
    [0155] Table 5 : Composition of the three dermocosmetic preparations in the form of separate creams for kinetic tests on skin hydration.
    [0156]
    [0157] The results obtained are illustrated graphically in Figs. 5 and 6. This is a graphic representation of the hydration kinetics of the skin measured by the corneometer for 24 hours after a single application of the placebo cream and creams with concentrations of 1% and 2% of the concentrate. , on the forearms of 20 volunteers with normal skin (Fig. 5) and on the forearms of 13 volunteers affected with sensitive skin (Fig. 6).
    [0158]
    [0159] From this Fig. 5 a remarkable increase in skin hydration is inferred after a single application of creams comprising a concentrate according to the invention with respect to the placebo cream. Likewise, a bimodal dynamic of interest is observed in which an immediate increase in hydration is distinguished within two hours of application and a long-term progressive increase (8h to 24h).
    [0160]
    [0161] Fig. 6 reveals an unexpected improved effect for users affected with sensitive skin. Indeed, note that although the effect of the cream with a concentration of 2% of the concentrate shows a value 15 points above the reference value at the hydration peak, this value is 20 points above the reference in the case of sensitive skin, which means approximately 5 points of improvement in the reparative response of the cream in sensitive skin.
    权利要求:
    Claims (7)
    [1]
    1. - A concentrate based on olive oil to be used as an active ingredient in a topically applied preparation for skin care characterized in that it comprises olive oil with an ORAC factor of at least 8 (^ mol equivalent Trolox / g) that it is enriched with at least one extract from the olive fruit rich in maslinic acid; and with at least one extract also from the fruit or olive leaf rich in Hydroxytyrosol.
    [2]
    2. - A concentrate based on olive oil according to claim 1, characterized in that the extract rich in Hydroxytyrosol has a richness of at least 20% in Hydroxytyrosol.
    [3]
    3. - A concentrate based on olive oil according to claims 1 or 2, characterized in that the extract rich in maslinic acid has a richness of at least 60% in maslinic acid.
    [4]
    4. - A concentrate based on olive oil according to any one of the preceding claims, characterized in that
    - the amount of malic acid present in the concentrate represents at least 0.040% by weight of the concentrate; and because
    - the amount of Hydroxytyrosol in the concentrate represents at least 0.010% by weight of the concentrate.
    [5]
    5. - A concentrate based on olive oil according to the preceding claim, characterized in that
    - the amount of malic acid present in the concentrate is between 0.045% and 1% by weight of the concentrate; and because
    - The amount of Hydroxytyrosol in the concentrate is between 0.020% and 1% by weight of the concentrate.
    [6]
    6. - A preparation for topical application for skin care comprising between 1% and 3% by weight of a concentrate based on olive oil according to any one of the preceding claims.
    [7]
    7. The use of a concentrate according to any one of claims 1 to 5 for the preparation of a dermocosmetic product.
    Ċ
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    同族专利:
    公开号 | 公开日
    EP3643293A1|2020-04-29|
    ES2756898B2|2021-11-26|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    ES2286953A1|2006-05-18|2007-12-01|Universidad De Granada|Formulation of natural triterpenes and biophenols obtained from the genus olea in liposomes|
    ES2311394A1|2007-02-22|2009-02-01|Universidad De Granada|Olive oil composition and use thereof as functional food|
    JP3958968B2|2000-03-31|2007-08-15|日清オイリオグループ株式会社|External preparation for skin and whitening agent|
    ES2389816B1|2011-04-07|2013-11-21|José María OLMO PEINADO|OLIVE SUB-PRODUCTION AND PROCEDURE FOR OBTAINING THE SAME|
    ES2395539B1|2011-06-16|2014-01-20|Agencia Pública Empresarial Sanitaria Hospital Alto Guadalquivir|Use of olive oil in the prevention and treatment of diseases that occur with an ischemic process|
    RO128713B1|2012-01-16|2019-07-30|Zbuchea Andrei-Gheorghe|Ointment with complex effects for treating burns and wounds, made exclusively of natural products|
    ES2462565B1|2012-11-22|2015-03-04|Biomaslinic S L|Dermocosmetic use of hydroxytyrosol to lighten the skin and compositions that comprise it|
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    申请号 | 申请日 | 专利标题
    ES201831041A|ES2756898B2|2018-10-26|2018-10-26|An olive oil-based concentrate and a topical skin care preparation comprising said concentrate|ES201831041A| ES2756898B2|2018-10-26|2018-10-26|An olive oil-based concentrate and a topical skin care preparation comprising said concentrate|
    EP19382848.0A| EP3643293A1|2018-10-26|2019-10-02|An olive oil-based concentrate and a topically applied preparation for skin care and repair comprising said concentrate|
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