• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Device for the detection and measurement of at least one analyte in aqueous medium and its method of use, simpler than known. The device comprises a base with a support with at least one biochip on which a sample, lighting means, a digital camera and a head that houses them are arranged, the support is in contact with the base and arranged between the head and the base, and is movable with respect to the base, means of introduction and removal of water to the sample, and the support has at least a first hole for the passage of water. The method of use comprises the steps: arranging sample in contact with the biochip; the sample aligns with the head; head contact with support; introduction of water; water extraction; lighting and photo taking, analysis of the color change of the sample. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2736038A1
    申请号:ES201830631
    申请日:2018-06-22
    公开日:2019-12-23
    发明作者:Calzada Saul Vallejos；Perez Jose Miguel Garcia；Garcia Felix Garcia；Arenas Felipe Serna；Alvarez Jon Mabe；Andoni Delagado；Alonso Patricia Lopez；Mediavilla Daniel Moreno
    申请人:Univ Internacional de la Rioja S A；Universidad de Burgos；
    IPC主号:
    专利说明:

    [0001]
    [0002] DEVICE FOR DETECTION AND MEASUREMENT OF AT LEAST ONE ANALYTE IN
    [0003]
    [0004] TECHNICAL FIELD OF THE INVENTION
    [0005]
    [0006] The present invention is included in the field of research or analysis of materials by the use of optical means, in particular those that use color measurement.
    [0007]
    [0008] BACKGROUND OF THE INVENTION
    [0009]
    [0010] Biochips are known as miniaturized electronic devices that have colorimetric property in the presence of certain analytes in aqueous media, and differ from sensor strips in several features and advantages:
    [0011] - very good optical properties, they are transparent;
    [0012] - very good manageability;
    [0013] - Covalent chemical bonds: it does not spread chemical species to the aqueous medium that it is analyzing.
    [0014]
    [0015] Patent WO2017085766A1 is known which discloses a device for the automatic detection and quantification of analytes in liquid samples with application to the determination of water quality. The device comprises a circular rotary support divided into sectors in which biochips are housed that react with the analyte to be determined, which have channels and reservoirs with reagents. The device also incorporates lighting means for irradiating the biochips and a unit for detecting the light emitted in response. The detected light is converted into an electrical signal and processed according to predetermined parameters to obtain a numerical value such as, for example, the amount of analyte. The biochips of this device are relatively complex and involve the inclusion of reagents.
    [0016]
    [0017] Patent ES2555161A1 is known which discloses a detection method and measurement of the concentration of chemical species in aqueous media in which reference is made to the use of polymeric colorimetric sensors in film form. The method comprises first contacting standard solutions of an analyte with a certain colorimetric chemical sensor and subsequently contacting the problem solution with said colorimetric chemical sensor. Next, photographs are taken of the sensors in contact with the standard solution and of the sensor in contact with the test sample. The images are sent to a database and processed for analysis. The processing includes the extraction of the RGB parameters related to color, the determination of a representative value of the RGB parameters associated with the color and the adjustment of the experimental curve to a mathematical expression that allows the detection and quantification of the problem analyte, thus generating the result for the user.
    [0018]
    [0019] US2007092975A1 is known, which discloses a device that allows simultaneous analysis of the concentrations of different analytes in an aqueous sample. For this, multiple sensors that change optical properties when reacting with a certain analyte are used. The sensors may include, among others, polymers that are housed in reservoirs to which the sample arrives, which is applied at a single point of entry, by means of channels through which it moves by capillarity. The system also comprises a light source that is projected onto the sensors and a detector that receives the optical response. Said response, for example a color image, is digitized and processed, allowing in said processing the determination of the concentration of each analyte in the sample. Like the patent cited above, the sensors of this device are relatively complex and involve the inclusion of reagents.
    [0020]
    [0021] DESCRIPTION OF THE INVENTION
    [0022]
    [0023] The present invention is established and characterized in the independent claims, while the dependent claims describe other features thereof.
    [0024]
    [0025] The object of the invention is a device for the detection and measurement of at least one analyte in aqueous medium and the method of use thereof, which are simpler than known devices and procedures. The technical problem to solve is to configure the device and to establish the steps of the procedure to reach the mentioned object.
    [0026]
    [0027] In view of the foregoing, the present invention relates to a device for the detection and measurement of at least one analyte in aqueous medium, comprising a base on which a support is provided comprising at least one biochip, of the known, on which an aqueous sample containing the analyte, lighting means of the sample and a digital camera can be arranged to capture an image of the sample, as is known in the state of the art. By quoting "at least one biochip" here it is meant that in what is explained below, both one and several biochips that are placed together to perform several measurements can be considered or several analytes are measured in each measurement.
    [0028]
    [0029] It characterizes the device which also comprises a head, the support is in contact with the base and disposed between the head and the base, said head is movable with respect to the base, usually by translation, from a first position separated from the support to a second position in contact with the support, the head includes the lighting means and the digital camera, the device also comprises means for introducing water to the sample and means for removing it, and the support has at least a first hole for The passage of water.
    [0030]
    [0031] An advantage is that the device is simple because it requires neither reservoirs nor the like in the biochip, but the sample is arranged directly on the biochip.
    [0032]
    [0033] The invention also relates to the method of the device described above comprising the following steps:
    [0034] to. placing the aqueous sample in contact with the biochip;
    [0035] b. support arrangement so that the sample of the stage is aligned with the first cavity of the head;
    [0036] c. movement of the head, from its first position separated from the support to its second position until it comes into contact with the support so that the sample and the biochip are housed in the first cavity;
    [0037] d. introduction of water to the first cavity by means of the water introduction means;
    [0038] and. extraction of water from the first cavity by means of the water withdrawal means, in which the passage of water through the first hole of the support is implicit; F. lighting of the sample by means of lighting means and taking a picture of the sample by the digital camera;
    [0039] g. sample color change analysis; Normally, the CIELAB 94 standard parameters are used to establish the permissible tolerances, such as establishing the color change by an increase in E (AE) with a standard procedure, although the color change can also be established as a custom-made procedure according to the need and the concrete application.
    [0040]
    [0041] An advantage of the invention is that it allows the monitoring of different parameters, such as iron concentration, pH, turbidity and conductivity, among others, in the field of the detection and monitoring of pollutants, species of environmental interest and physical properties.
    [0042]
    [0043] Another advantage of the invention is that being able to include as many biochips as required allows continuous analysis and instant quality control, for example in industrial plants where one or more steps / stages are performed in which a Excessive concentration of a given species can spoil an entire lot, because until the quality control step the problem is not detected, and it is usually already late. With the proposed invention, this problem can be detected at the moment, and the corresponding actions can be carried out.
    [0044]
    [0045] The invention is of advantageous application to the control of industrial process water, drinking water, wastewater, and ultimately any aqueous medium in which one or more chemical species is to be detected, controlled and / or monitored.
    [0046]
    [0047] BRIEF DESCRIPTION OF THE FIGURES
    [0048]
    [0049] The present specification is complemented with a set of figures, illustrative of the preferred example, and never limiting the invention.
    [0050] Figure 1 represents a rear perspective view of the device.
    [0051]
    [0052] Figure 2 represents the device of Figure 2, on a smaller scale and with a cover.
    [0053]
    [0054] Figure 3 represents a perspective view of certain components of the device of Figure 1, in which the head can be seen.
    [0055]
    [0056] Figure 4 represents the device of Figure 3, with a base and a disk-shaped support with various biochips.
    [0057]
    [0058] Figure 5 represents a perspective view of a sectional detail of Figure 3 showing the head.
    [0059]
    [0060] Figure 6 represents a plan view of a photograph of several biochips placed in contact with an analyte.
    [0061]
    [0062] Figure 7 shows a color adjustment graph for the calculation of the analyte concentration.
    [0063]
    [0064] Figure 8 represents a perspective view of a tape-shaped support with a coil winding at one end, showing a barcode next to each biochip and reference pair.
    [0065]
    [0066] Figure 9 represents a perspective view of a device with a tape-shaped support.
    [0067]
    [0068] DETAILED EXHIBITION OF THE INVENTION
    [0069]
    [0070] Figure 1 shows a device for the detection and measurement of at least one analyte in aqueous medium, comprising a base (1) on which a support (2) is provided, in the form of a disk in this figure and in the Figure 4, comprising at least one biochip (2.1) on which an aqueous sample, not shown in the figures, containing the analyte, lighting means (3) of the sample, of the type can be arranged led in the embodiment shown and shown in figure 5, and a digital camera (4), also shown in figure 5, to capture an image of the sample.
    [0071]
    [0072] The device comprises a head (5), shown in Figures 1.3 to 5, the support (2) is in contact with the base (1) and disposed between the head (5) and the base (1), said head (5) is movable, usually by translation, with respect to the base (1) from a first position separated from the support (2), as shown in Figure 3 in which the support (2) is not included, to a second position in contact with the support (2), as shown in figure 4. The head (5) includes the lighting means (3) and the digital camera (4), as shown in figure 5. The means of illumination (3) are shown arranged parallel to the biochip (2.1) and, therefore, to the sample, although they could acquire an inclination, for example of 45 ° with respect to the horizontal, or any other.
    [0073]
    [0074] The device also comprises means for introducing water to the sample (6) and means for withdrawing it (7), as seen in Figures 1, 3 and 9, and the support (2) has at least a first hole (2.2) for the passage of water, as shown in Figure 4.
    [0075]
    [0076] The embodiment of Figure 1 is a compact device with a cover (1.6) that protects the support (2) both during operation and for transporting the device. As can be seen in figures 1 and 4, the device includes two PCB boards (9) in which the different electronic components are arranged. In order to favor the compactness of the embodiment shown, said plates (9) have been divided into two sections, one arranged at the top and one at the rear, although they could be arranged in any other way depending on the specific embodiment of the assembly.
    [0077]
    [0078] Likewise, other elements known as solenoid valves for controlling the entry and exit of water to the device are included in the embodiment. In Figure 5 it is shown that the lighting means (3) are of the LED type, which is preferred although they could be of another type, and in front of them there is a diffusing lens (10) to blur the light rays as is known . Also, in figure 5 it is shown that the head is divided into two parts to house an element transparent protector (11), both parts tightly connected by means of third sealing means (5.3). In the embodiment shown in Figure 5, the digital camera (4) is an electronic component fixed to the same plate (9) as the lighting means (3), and the head (5) has a tubular projection (5.4) facing said digital camera (4) as a camera lens, which makes the diffuser lens (10) annular.
    [0079]
    [0080] A detail of the embodiment, shown in Figure 5, is that the head (5) comprises a first cavity (5.1) to house the biochip (2.1) and allows the rays of the lighting means (3) to exit to the sample and the input of reflected light from the sample to the digital camera (4). In the same figure 5 the detail is appreciated that the first cavity (5.1) has a second hole (6.3) for the entry of water.
    [0081]
    [0082] Another detail of the embodiment, shown in Figure 5, is that the head (5) comprises first sealing means (5.2) surrounding the first cavity (5.1) at the end of the head (5) that can come into contact with the support (2). In the same sense, another detail, shown in Figures 3 and 5, is that the base (1) comprises a support (1.2) for the support (2), said support (1.2) comprises a second cavity (1.3) and about second sealing means (1.4), figure 5, surrounding it.
    [0083]
    [0084] Another detail of the embodiment, shown in Figures 3 and 5, is that the second cavity (1.3) has at least a third hole (1.5) for the water outlet of the sample, in the shown embodiment two holes are shown to facilitate The passage of water.
    [0085]
    [0086] Another detail of the embodiment, shown in Figure 1, is that the water introduction means (6) comprise an entrance to the base (6.1) and an entrance to the head (6.2), the water withdrawal means (7) they comprise an exit of the support (7.2), this one shown in figure 2, and an exit of the base (7.1). The detailed explanation of the pipes through which the water passes, which are tubular pipes of the known ones, is obvious, assuming that the path of the water from the entrance to the base (6.1) is understood, passing through the device as explained, until the base exit (7.1).
    [0087] Another detail of the embodiment, shown in Figures 4 and 8, is that next to the biochip (2.1) a reference (2.3) of the sample size is arranged, so that the first cavity (5.1) can house the biochip (2.1), to reference (2.3) and to the first hole (2.2), this first hole (2.2) is not represented in figure 8, for simplicity of representation of the figure.
    [0088]
    [0089] In the embodiment shown in figures 1 to 4, the configuration is shown that the base (1) comprises turning means (1.1), figure 3, on which the support (2), figures 1 and 4, are arranged, the support (2) is rigid, in particular in the form of a disk, so that it can rotate in solidarity with said turning means (1.1), which can be a direct current motor of the known ones that together with a discoidal configuration such as the one shown in the figures serves so that the support (2) in the form of a disk rests on it and is inserted through a central hole that presents in a protuberance of said discoidal configuration. While in figures 8 and 9 the configuration is shown that the device comprises winding and unwinding means (8) which in turn comprise two coil shafts (8.1), only one is explicitly seen in figures 8 and 9 , in figure 9 another axis is assumed in the coil partially represented on the back of the device, the support (2) is flexible so that it can be unwound from one coil axis (8.1) to be wound on the other coil axis.
    [0090]
    [0091] In Figure 8, two different types of biochips (2.1) have been arranged that produce different color gamut in their reaction, such as one being in the range of greens and another in the range of blues, for example; It can also be implemented in disk configuration. Also, in the embodiment set forth in Figures 8 and 9, the option is added that next to each pair of biochip (2.1) and reference (2.3), a barcode (2.4) is added that helps the coding of each biochip (2.1), and may include information such as lot number, expiration date, type of biochip (2.1), etc. This possibility has been shown in the embodiment of flexible roller support of these figures but it can also be implemented in the disk configuration of the previous figures.
    [0092]
    [0093] The method of using a device as described for the Detection and measurement of at least one analyte in aqueous medium comprises the following steps:
    [0094] to. placement of the aqueous sample in contact with the biochip (2.1);
    [0095] b. arrangement of the support (2) so that the sample of the stage is aligned with the first cavity (5.1) of the head (5);
    [0096] c. movement of the head (5) until it comes into contact with the support (2) so that the sample and the biochip (2.1) are housed in the first cavity (5.1);
    [0097] d. introduction of water to the first cavity (5.1) by means of the water introduction means (6);
    [0098] and. extraction of water from the first cavity (5.1) by means of the water withdrawal means (7);
    [0099] F. lighting of the sample by means of the lighting means (3) and taking a photo of the sample by the digital camera (4);
    [0100] g. Sample color change analysis.
    [0101]
    [0102] One option is that stage g is carried out by comparison with a reference (2.3) arranged next to the biochip (2.1). Thus, it is said that each measure is self-calibrated.
    [0103]
    [0104] Stage g can be carried out "in situ" by the same device. However, depending on the need, one option is that after stage f the photo is sent by cable or wireless communication to an external station, not shown in the figures, to carry out the analysis stage g, so that it It is not carried out at the site where the device operates, but away from it, sometimes due to confidentiality of the data taken. Currently, Wi-Fi type wireless communication is more common, which can even be used to communicate with a smartphone, reserving the cable connection for maintenance work.
    [0105]
    [0106] Another option is that stage g of analysis is carried out when in stage e all the water has been extracted from the sample, which is considered as a point measure. An alternative is that the analysis stage g is carried out when the stage e of extraction of the water from the sample has not been completed, but during the passage of water through the sample, that is, the analysis is carried out having current from water on the sample, which is considered as a continuous measurement, necessary in some chemical species that require a continuous water flow.
    [0107]
    [0108] Another option is that the contact of stage c is carried out in a sealed manner by means of the first sealing means (5.2) surrounding the first cavity (5.1) at the end of the head (5) and the second sealing means (1.4) surrounding the second cavity (1.3) of the support (1.2). This is the option represented in Figures 1 and 4, carried out by means of O-rings as a means of sealing, which are simple and effective, however, they are not strictly necessary nor are they the only option as a means of sealing. means such that the sealing is made by the same materials in contact with each other by compression, or that some include a lip or configuration that makes the sealing, such as an added lip or even over-injected if the configuration allows.
    [0109]
    [0110] Another advantageous option to carry out the continuous process is that after stage g the head (5) is separated from the support (2), the steps ag being repeated, and can be repeated consecutively for all the biochips (2.1) of the support (2). Stage b refers to the advance of the support (2), which will be a rotation in the case represented of the disk in figures 1 to 4, of unwinding-winding in the case represented in figure 9, or of any other that is implemented as the case may be, such as a straight strip that will move by translation, etc. One option is that the head (5) has in addition to the two specified positions, a first position separated from the support and a second position in contact with the support, a third position in which it is very separate from the support (2), more separated that in the first position, this is advantageous so as not to become contaminated when passing from one biochip (2.1) to another; Such contamination can also be avoided if instead of moving from a used biochip (2.1) to an unused one directly when it is in the first position, not far from the support (2), it passes through the used biochips (2.1) before separating to the third position, further away, and moving to the unused biochip (2.1), obviously this is possible when the support (2) is relatively small like the disk or a strip, it is not applicable for example when it is of the roll type because it is not Productively unwind everything rolled up to rewind it.
    [0111] As an example, it can be mentioned that the measurement is carried out in fluids of viscosity between 0.5 cSt and 2.5 cSt at a pressure between atmospheric and 10 bar. The digital camera (4) is compatible with fluids with turbidity levels below 15 NTU. The lighting means (3) are stable (± 5% error) under laboratory conditions (21 ° C) and homogeneous throughout the measurement area (± 10% error). Thus, for example, the photo of the biochips when they have been put in contact with the sample that contains a contaminant - analyte - shows a green color and is related to clean water, that is, low or no concentration of the contaminant, an orange color means high concentration of the contaminant, Figure 6 shows an illustrative example in which the photograph covers from one state, clean green water (V), to the other opposite, orange contaminated water (N), showing the gradation from one to the other . Likewise, a color adjustment graph is usually prepared for the calculation of the concentration of the contaminant, figure 7 representing the log of the concentration of a contaminant, abscissa axis, versus the main components of the color (RGB), axis of neat.
    权利要求:
    Claims (18)
    [1]
    1. Device for the detection and measurement of at least one analyte in aqueous medium, comprising a base (1) on which a support (2) is provided comprising at least one biochip (2.1) on which it can be arranged an aqueous sample containing the analyte, lighting means (3) of the sample and a digital camera (4) to capture an image of the sample, characterized in that it also comprises a head (5), the support (2) is in contact with the base (1) and arranged between the head (5) and the base (1), said head (5) is movable with respect to the base (1) from a first position separated from the support (2) to a second position in contact with the support (2), the head (5) includes the lighting means (3) and the digital camera (4), the device also includes means for introducing water to the sample (6) and withdrawal means thereof (7), and the support (2) has at least a first hole (2.2) for the passage of water.
    [2]
    2. Device according to claim 1 wherein the head (5) comprises a first cavity (5.1) that can house the biochip (2.1) and allows the rays of the lighting means (3) to exit to the sample and the input of reflected light from the sample to the digital camera (4).
    [3]
    3. Device according to claim 2 wherein the first cavity (5.1) has a second hole (6.3) for the entry of water.
    [4]
    4. Device according to claim 2 wherein the head (5) comprises first sealing means (5.2) surrounding the first cavity (5.1) at the end of the head (5) that can come into contact with the support (2 ).
    [5]
    5. Device according to claim 1 wherein the base (1) comprises a support (1.2) for the support (2), said support (1.2) comprises a second cavity (1.3) and second sealing means (1.4) surrounding it.
    [6]
    6. -Device according to claim 5 wherein the second cavity (1.3) has at least a third hole (1.5) for the water outlet of the sample.
    [7]
    7. Device according to claim 5 wherein the water introduction means (6) comprise an entrance to the base (6.1) and an entrance to the head (6.2), the water withdrawal means (7) comprise an outlet of the support (7.2) and an exit from the base (7.1).
    [8]
    8. -Device according to claim 7 in which next to the biochip (2.1) a reference (2.3) of the sample measurement is arranged, so that the first cavity (5.1) can house the biochip (2.1), a the reference (2.3) and the first hole (2.2).
    [9]
    9. -Device according to claim 8 in which next to each pair of biochip (2.1) and reference (2.3) there is a bar code (2.4)
    [10]
    10. - Device according to claim 1 wherein the base (1) comprises turning means (1.1) on which the support (2) is arranged, the support (2) is rigid so that it can rotate in solidarity with said turning means (1.1).
    [11]
    11. Device according to claim 1 comprising winding and unwinding means (8) which in turn comprise two coil axes (8.1), the support (2) is flexible so that it can be unwound from a coil axis ( 8.1) to roll up on the other.
    [12]
    12. Method of using a device according to claim 1 for the detection and measurement of at least one analyte in aqueous medium, characterized in that it comprises the following steps:
    to. placement of the aqueous sample in contact with the biochip (2.1);
    b. arrangement of the support (2) so that the sample of the stage is aligned with the first cavity (5.1) of the head (5);
    c. movement of the head (5) until it comes into contact with the support (2) so that the sample and the biochip (2.1) are housed in the first cavity (5.1); d. introduction of water to the first cavity (5.1) by means of the water introduction means (6);
    and. extraction of water from the first cavity (5.1) by means of the water withdrawal means (7);
    F. lighting of the sample by means of the lighting means (3) and making a photo of the sample by the digital camera (4);
    g. Sample color change analysis.
    [13]
    13. -Procedure according to claim 12 wherein step g is carried out by comparison with a reference (2.3) arranged next to the biochip (2.1).
    [14]
    14. -Procedure according to claim 12 wherein after step f the photo is sent by cable or wireless communication to an external station to carry out the analysis stage g.
    [15]
    15. -Procedure according to claim 12 wherein step g of analysis is carried out when in stage e all the water has been extracted from the sample.
    [16]
    16. -Procedure according to claim 12, wherein the analysis stage g is carried out when the stage e for extracting the water from the sample has not been completed, but during the same step of water passing through the sample.
    [17]
    17. -Procedure according to claim 12 wherein the contact of stage c is carried out in a sealed manner by means of the first sealing means (5.2) surrounding the first cavity (5.1) at the end of the head (5) and of the second sealing means (1.4) surrounding the second cavity (1.3) of the support (1.2).
    [18]
    18. -Procedure according to claim 12 wherein in step g the head (5) is separated from the support (2), the steps a-g being repeated, and can be repeated consecutively for all biochips (2.1) of the support (2).
    类似技术:
    公开号 | 公开日 | 专利标题
    ES2791181T3|2020-11-03|Test strip and methods and apparatus for reading the same
    ES2696600T3|2019-01-17|Test apparatus for testing and software for a portable device
    KR20170024300A|2017-03-07|Mobile multi-air quality measurement system using a drone
    AU2014261825B2|2018-09-06|Device for analysis of cellular motility
    US20190094146A1|2019-03-28|Method and apparatus for continuous gas monitoring using micro-colorimetric sensing and optical tracking of color spatial distribution
    ES2736038B2|2021-04-06|DEVICE FOR THE DETECTION AND MEASUREMENT OF AT LEAST ONE ANALYTE IN AQUEOUS MEDIUM AND PROCEDURE FOR THE USE OF THE SAME
    ES2890884T3|2022-01-24|Methods and devices for performing an analytical measurement based on a color-forming reaction
    CN107807093B|2021-03-23|Fluid sensor device
    GB1341288A|1973-12-19|Exposure calculator and filter device for darkroom colour photography
    JP5821885B2|2015-11-24|Inspection specimen and analyzer
    KR20190039880A|2019-04-16|A system for conditioning air quality in a closed environment
    KR102202027B1|2021-01-12|Device and system for monitoring water quality based on IoT
    EP3293512B1|2020-08-05|Colorimetric gas detection
    US20200400584A1|2020-12-24|Fluid sensor card
    CN110226085B|2022-02-01|Urine test paper comprising timer, and urine test paper detection and analysis method
    ES2555161B1|2016-10-07|Procedure for measuring the concentration of chemical species
    KR20180056235A|2018-05-28|Sensor for measuring concentration of substance by color changing, sensing system including sensor and method of manufacturing sensor
    US8993972B2|2015-03-31|Fluorescence based sensors utilizing a mirrored cavity
    JP2019537006A|2019-12-19|Portable microfluidic device for nitrite-nitric acid detection
    Mills et al.2010|Application of passive sampling techniques for monitoring the aquatic environment
    JP6722841B2|2020-07-15|Optical measuring device
    US11175234B2|2021-11-16|System for visual and electronic reading of colorimetric tubes
    WO2021247750A1|2021-12-09|Optical imaging of smart hydrogel structures for sensing applications
    JP4628134B2|2011-02-09|Live bacteria detection method and live bacteria detection tool
    同族专利:
    公开号 | 公开日
    ES2736038B2|2021-04-06|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US4291986A|1978-12-14|1981-09-29|Hitachi, Ltd.|Optical rate assay apparatus|
    WO1995008774A2|1993-09-24|1995-03-30|Abbott Laboratories|Automated continuous and random access analytical system and components thereof|
    WO2008080074A2|2006-12-21|2008-07-03|Johnson & Johnson Vision Care, Inc.|Interferometry testing of lenses, and systems and devices for same|
    WO2014031327A2|2012-08-20|2014-02-27|Siemens Healthcare Diagnostics Inc.|Clam-shell luminometer|
    WO2017085766A1|2015-11-16|2017-05-26|日立化成株式会社|Centrifugal analysis device and centrifugal analysis chip|
    法律状态:
    2019-12-23| BA2A| Patent application published|Ref document number: 2736038 Country of ref document: ES Kind code of ref document: A1 Effective date: 20191223 |
    2021-04-06| FG2A| Definitive protection|Ref document number: 2736038 Country of ref document: ES Kind code of ref document: B2 Effective date: 20210406 |
    优先权:
    申请号 | 申请日 | 专利标题
    ES201830631A|ES2736038B2|2018-06-22|2018-06-22|DEVICE FOR THE DETECTION AND MEASUREMENT OF AT LEAST ONE ANALYTE IN AQUEOUS MEDIUM AND PROCEDURE FOR THE USE OF THE SAME|ES201830631A| ES2736038B2|2018-06-22|2018-06-22|DEVICE FOR THE DETECTION AND MEASUREMENT OF AT LEAST ONE ANALYTE IN AQUEOUS MEDIUM AND PROCEDURE FOR THE USE OF THE SAME|
    [返回顶部]