• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
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    • 专利摘要:
    Transluminal device and procedure for the mechanical characterization of structures. The invention describes a device comprising at least one emitter of P and/or S waves, preferably shear waves, more preferably axisymmetric waves, and at least one wave receiver, in which the receiver or receivers are arranged concentrically and the disposition of the transmitters and receivers allows them to enter, simultaneously, in direct contact with the specimen whose structure is to be characterized. A procedure is also described to characterize the spatial distribution of mechanical parameters of a specimen based on the emission of shear waves and their subsequent reception. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2687485A1
    申请号:ES201730415
    申请日:2017-03-24
    公开日:2018-10-25
    发明作者:Guillermo Rus Calborg；Nader SAFFARI；Antonio GÓMEZ FERNÁNDEZ；Elena SÁNCHEZ MUÑOZ
    申请人:Universidad de Granada；
    IPC主号:
    专利说明:

    TRANSLUMINAL DEVICE AND PROCEDURE FOR THE MECHANICAL CHARACTERIZATION OF STRUCTURES
    SECTOR OF THE TECHNIQUE
    The present invention is related to piezoelectric transducers widely used in the industries of medical diagnosis, industrial and aeronautical monitoring, among others. It is a transluminal device for the generation and reception of mechanical shear waves in soft solid media with a coefficient of 10 Poisson close to 0.5 (quasi-incompressible media) containing an accessible lumen, such as gels and other viscous fluids. This type of device allows obtaining information on the elastic characteristics of the medium to be studied and its distribution throughout it. In certain situations, changes in consistency in the tissue may indicate the presence of certain pathologies, which would allow the use of this
    15 technique for diagnosis. In turn, certain focused heat treatments generate irreversible transformations in the consistency of the tissue, so that their evolution could be monitored.
    Its field of application ranges from non-destructive analysis and mechanical characterization
    20 materials, up to quantitative dynamic elastography of biological tissues. In particular, this invention is applicable to perform transurethral elastography analysis for the diagnosis of prostate cancer and monitor thermal ablation as a focused therapy of prostate cancer.
    25 STATE OF THE TECHNIQUE
    The mechanical shear waves, also known as shear waves, applied transluminally in a particular segment of the luminal wall, form a quasi-spherical distribution of shear waves that propagate from the area of
    30 application on the lumen wall into the middle. Its behavior is basically governed by the viscoelastic parameters of shear of the medium.
    The propagation of the shear waves is governed by the mechanical shear parameters of the medium to be studied. In the case of longitudinal waves, it is the 35 volumetric compressibility parameters that govern its behavior. At
    In the case of first application of the invention, prostate imaging, as well as in most soft tissues, the compressibility parameters vary only in percentage fractions, while the shear varies in several orders of magnitude. This allows using image techniques based on sharp wave transducers can detect
    5 alterations in the elasticity of the medium where techniques based on compression wave transducers do not allow. A clear example of this phenomenon is the image of rigid prostate tumors
    A transducer is a device capable of transforming or converting a certain type
    10 of input energy, in another of different to the output. Among these devices are electromechanical transducers, which transform electrical energy into mechanics in the form of displacements coupled elastically with voltages, in a bidirectional way. Piezoelectric transducers are a type of electromechanical transducer, which emit and receive mechanical waves allowing applications of
    15 ultrasound and / or elastographic image.
    Torsion-based shear wave generators with applications in geophysics are known. This is the case of US 5,321, 333, which presents a bilateral device (generates two waves at each end) to generate shear movements based on
    20 in the combination of polarized piezoelectric elements, which are attached to a solid rod to transmit the movement. However, applications in geophysics, unlike those in biomedicine, use very low frequencies since the elements to be monitored are on the meter scale.
    25 Transducers that emit torsion waves from accessible surfaces with soft tissue elastography applications are also known, such as those described in WO 2012172136. In this patent, the generation of torsion waves is performed thanks to a transmission disk that combines a torque of elastic discs that provides the necessary inertia to reduce the resonance frequency and stiffness to reduce the
    30 expansion waves, and a selection of transversely polarized piezoelectric elements that transform the electrical signal into mechanical movement. However, the signal received with the described devices contains too much noise, so their analysis presents serious difficulties. The lack of quality of this signal does not allow a correct reconstruction of the mechanical characteristics of the medium in certain
    35 situations
    In the application WO / 20171009516 an electromechanical device is described that allows to emit axisymmetric waves and that contacts the tissue by a face perpendicular to the axis of rotation of the contact element.
    Vascular elastography devices are also known, such as that described in US 20070282202 A 1. This patent details the design and use of a system for quasi-static vascular elastography. This type of elastography is based on the comparison of the radio frequency signals obtained before and after applying a compression strain to the tissue to be studied. The result is a contrast elasticity map, but without quantitative information about the mechanical parameters of the tissue.
    Transluminal devices with applications in quantitative dynamic elastography are not known as of this document.
    In the specific case of the first application of this invention, we can find different types of prostate elastography, however, none of them is performed through the urethra.
    Prostate elastography
    Prostate Elastography is an emerging modality of medical imaging, which consists of the evaluation of the rigidity of the prostate. Similarly to the wound healing process, it is believed that the normal tissue stroma responds in an effort to repair the damage caused by the invasion of cancer cells. Said reaction is characterized by a high deposition of COlagen. Since the increase in the deposition of COlágeno with leads to an increase in the stiffness of the cancerous tissue, it has been suggested in numerous studies that the quantitative estimation of tissue stiffness can be an effective biomarker to assess the degree of prostate cancer. Identify the most aggressive tumors.
    Real-time elastography is available in some ultrasound systems for prostate imaging along with other techniques that are currently being developed.
    Currently, two different approaches to elastography are commercially available:
    • Quasi-static elastography, also known as Strain Elastography (SE).
    • Dynamic elastography, mainly using Acoustic Radiation Force (ARF).
    Quasi-static elastography (SE) in the prostate is based on the comparative analysis of tissue deformation before and after applying a slight mechanical compression through the wall of the rectum. The more rigid areas experience less deformation than those less rigid areas. Relative changes in the degree of deformation
    10 provide an idea of areas with a higher stiffness and therefore suspected of containing pathogenic nodules. Quantitative values of stiffness are not provided. This technique is commercially available on several medical ultrasound platforms. It has some limitations:
    • Lack of non-uniform compression over the entire prostate, which can lead to false interpretations.
    • Intra-e inter-operational dependence.
    • Difficulty penetrating larger prostates.
    • Artifacts due to landslides in the compression plane.
    20 Dynamic elastography for the detection of prostate cancer has been mainly tested using Shear Wave Elastography (SWE) transrectally using the Aixplorer ultrasound equipment (SuperSonic Imagine, Aix-en-Provence, France). In transrectal SWE the ARF generates a shear wavefront with a conical geometry of small inclination. This wave propagates within the tissue from the area of
    25 generation of the ARF outwards. An ultrafast ultrasound scanner allows real-time monitoring of wave propagation, thus obtaining its propagation speed and therefore a tissue elasticity map. The spatial resolution is worse than that generated by SE, but quantitative stiffness values are provided.
    30 Recent studies on prostate cancer diagnosis using SWE transrectally have shown very promising results. The use of a Young Threshold module between lesions and normal 35 kPa tissue in the peripheral area of the prostate can provide additional information for cancer detection and biopsy guidance, allowing a substantial reduction in the final number of biopsies to be performed. . The
    35 limitations of this technique are:
    • Pressure artifacts due to the transrectal transducer design, which requires tilting the probe to scan the middle prostate and its vertex.
    • Slow acquisition of images, specifically one image per second.
    • Limited size of the region of interest, specifically only a 5-20 plane of half of the prostate is covered.
    • Delay in the stabilization time of the signals for each acquisition plane.
    • Signal attenuation in large prostates, which makes it difficult to evaluate the anterior area of the prostate.
    The reason why it is not immediate to design a transluminal ultrasonic probe with the capacity to generate enough acoustic radiation (Acoustic Radiation Force) to generate a shear wave propagating inside the tissue is mainly the lack of space to contain the size of acoustic lens that is
    15 technique required. At the same time a lack of space would be observed to incorporate the monitoring system of the shear wave propagation. That is why it is necessary to think of a design where the shear wave is generated by mechanical actuators, and where the detection system allows its miniaturization.
    20 Mechanical characterization of structures The physical principle to mechanically characterize the structure of a medium is as follows: A physical quantity is propagated in a waveform through the medium to be analyzed, which distorts the wave until it is measured in an accessible sub-surface. The mechanical parameters responsible for wave modification can be deduced at
    25 based on the measurements that are made through the theory of the inverse problem based on models. This technique is the most powerful strategy known so far.
    The use of Genetic Algorithms for the optimization of cost functions whose variables are the mechanical parameters to be quantified has been previously described. Another 30 complementary methods such as Reverse Time Migration can help reduce the size of the optimization domain of the Genetic Algorithm.
    OBJECT OF THE INVENTION
    The object of the invention is a piece-electromechanical transducer probe containing a set of transmitters and receivers of sharp waves for solid, quasi-compressible media and some fluid gels, from a cavity inside the medium, or by inserting the probe through an accessible surface in the case of fluid gels. 5 The rotational oscillatory force induced by each emitter is transmitted in the middle in the form of pseudo-spherical radiation of sharp waves. The analysis of the waves detected by the receptors, once they have traveled through the tissue, allows obtaining valuable information about the elastic being and its spatial distribution, which would allow, for example, to detect areas of greater rigidity that could be associated with
    10 tumors All existing methods of prostate elastography are based on the transrectal approach. In the case of this invention, access to the gland would be transurethral, which entails a series of inherent advantages:
    • Better accessibility to the anterior area of the prostate, which is less accessible when transrectal access is used.
    • Possibility of using frequencies (higher than 500 Hz) higher than those currently used. This would allow a greater spatial resolution and therefore a better capacity to detect small tumors.
    • Ability to scan the entire gland in a single process, thus obtaining a 3D map of mechanical parameters of the tissue.
    • Low thermal and mechanical levels compared with techniques that use ARF as a source of excitation of sharp waves.
    • The use of the urethra as an access channel keeps the rectal passage free for
    transrectal therapies such as thermal ablation using HIFU, which would allow their monitoring.
    Thus, a first aspect of the invention consists of a transluminal or intraluminal probe to analyze the structure of a specimen comprising at least one emitter of S waves or P and S waves, preferably shear waves, more preferably 30 axisymmetric waves, and at least one wave receiver, in which the receiver or the receivers are arranged concentrically and the arrangement of the emitters and receivers allows them to simultaneously enter into direct contact with the specimen.
    In a second aspect, the invention relates to a method for obtaining data useful for characterizing the spatial distribution of mechanical parameters of a
    specimen, in particular elastographic analysis of the specimen, preferably theobtaining useful parameters as biomarkers, which includes the emission ofP and / or S waves, preferably shear waves, more preferably wavesaxisimetric, and the extraction of mechanical constants from the reception of waves5 reflected from a probe located inside a vessel or duct of the specimen.
    DESCRIPTION OF THE FIGURES
    Figure 1.- Representation of two concentric arrangements of the recipients of the
    10 probe (S) of the invention where ® represents a receiver and (d) the distance from the outer surface of the receiver to the longitudinal axis, (O).
    Figure 2.-Schematic representation of an emitter formed by an element of
    contact (C) with a substantially toroidal shape connected by its inner part to four
    15 piezoelectric elements (pcs). (O) represents the longitudinal axis of the probe of the invention, (T) the direction of movement of the contact element and (E) a central element on which the different elements that make up the area are fixed.
    Fig ura 3.-Schematic representation of an emitter or receiver formed by a
    20 contact element (C) with a substantially toroidal shape connected by its inner part to four piezoelectric elements (pz). (O) represents the longitudinal axis of the probe of the invention, (T) the direction of movement of the contact element and E a central element on which the different elements that make up the area are fixed.
    25 Figure 4.-Schematic representation of two sets of 3 and 4 receivers formed by contact elements (C) in the form of a toroid segment whose axis of revolution coincides with the center on the longitudinal axis (O) and whose inner part is fixed a piezoelectric element (pz) with a polarization that allows a rotation movement with tangential direction (T) to be transformed to the outer surface of the contact element in
    30 an electrical signal. E a central element on which the different elements that make up the area are fixed.
    Figure 5.-Scheme of a particular embodiment of the device with 5 sets of 4 receivers (j = 5, k = 4). (O) represents the longitudinal axis of the probe of the invention and € 35 a central element on which the different elements that make up the area are fixed.
    Figure 6.-Schematic representation of the position of the probe inside a
    vessel (V) of a specimen (Sp).
    5 Figure 7.-Schematic representation of the position of the probe inside avessel (V) of a specimen (Sp) before and after air suction.
    Figure 8.-Scheme of an embodiment in which the probe comprises four sets of 4 receivers (receivers) and a wave emitter (emitter) with a toroidal shape.
    Figure 9.-Scheme of an embodiment in which the probe comprises four receivers (receivers) and a wave-shaped emitter (transmitter) and is connected to an electromagnetic motor (Motor).
    15 Figure 10.-Experimental signals obtained with the prototype in simulated prostate with 13% gel.
    Figure 11.-Simulated signals for the simulated prostate prototype with 13% gel.
    Detailed description of the invention
    Definitions
    Throughout this specification "axisymmetric shear wave" or "ASW '(axisymmetric shear wave) shall be understood as a mechanical shear wave propagated in media
    Quasi-incomprehensible, preferably biological tissues, governed by the deviating component of elasticity and which propagates at the shear velocity of 30 shears, in radial and axial direction, according to the first approximation mathematical model described below.
    The equations that describe the propagation of the axisymmetric wave, as well as the angular oscillatory displacement that the particles of the medium undergo the passage of the wave can be described by the equations of conservation of amount of movement, of balance between deformations and displacements, and finally mechanical constituents of the propagation medium. This last group of equations describes how
    the means of propagation responds in terms of deformation when subjected to stress, numerous constitutive models have been proposed, this document describes the so-called Kelvin-Voigt Fractional Derivative (KVFD), as it is a generalization of other simpler constitutive models, in addition of being postulated in recent literature as one of the ideal constitutive models for dynamic elastography simulation:
    Conservation of the amount of movement:
    (} 2u o = ~ (iJ (Tro + i) uoz + ~ u)
    at2 p ar az r rO
    Where Uo is the angular displacement of the particles, p is the density of the propagation medium, t is time, UrO Y (Toz are shear stresses, r is
    the radial coordinate and z is the axial coordinate.
    Balance between deformations and displacements:
    and. = ~ (aUO _UO) _
    I
    2iJr r '
    1 year COz = '2 az
    Where cro and coz are shear deformations.
    KVFD constitutive model:
    aa CrO
    arO = 2J..lErO + 21] -; ¡¡c; -; Or <a <2 aa coz
    (Toz = 2J..lEoz +21] -; ¡¡c; -; or <a <2
    Where J..l is the instantaneous elastic behavior component of the propagation medium, 1J is the viscous behavior component of the propagation medium, it is already the order of the fractional derivative, also related to the power law that describes the attenuation of the wave depending on the frequency of it.
    We will say that a device is "intraluminate or" transluminate when it is suitable to be introduced inside a vessel or duct. A catheter or bladder catheter is considered transluminal devices.
    "Toroid" means a surface of revolution generated by a simple closed flat curve or a polygon that rotates around a coplanar outer line (axis of rotation) with which it does not intersect.
    It will be said that a plurality of wave emitters or receivers located in an intraluminal device are "concentrically arranged" or "equidistant from the longitudinal axis [Fig. 1], when the distance, d, from the outer surface of the emitters or receivers, R, to the longitudinal axis, O, of the device, S, is constant, by extension, this definition also includes the case in which an emitter or receiver has a cylindrical surface or toroidal shape and its axis of revolution coincides with The axis of the device.
    Throughout this description we will understand as "specimen" the material, preferably woven, more preferably living tissues, through which the waves emitted by the transducer are passed to know their structural characteristics (elastic, viscoelastic parameters, microstructural geometry, porous, or models of energy dissipation, among others).
    For the purposes of the present invention, "electromechanical actuator" shall be understood as a device capable of transforming electrical energy into a movement, particularly a rotational movement. In a particular embodiment, suitable for this invention, the electromechanical actuator is stimulated with an electrical signal generated by an electric pulse generator and is capable of transforming that signal into a minimum turn fraction, which will be used to generate the wave that is subsequently analyzed. . In a more particular embodiment, the electromechanical actuator will be an electromagnetic motor, so that the rotation is induced by transforming electrical energy into magnetic.
    An example of this type of actuator may consist of a small-sized or micromotor electromagnetic motor.
    For the purposes of the present invention, the electromechanical actuator is stimulated by means capable of generating waves or electrical signals, hereinafter "generator of electrical signals".
    We will understand by "electrical signal" an electrical magnitude whose value depends on time. For the purposes of the present invention, constant magnitudes will be considered as particular cases of electrical signals.
    The electrical signals generated by an electric signal generator can be periodic (sine, square, triangular, shaped like "sawtooth", etc.). Thus, when connected to an actuator that transforms the signal into a rotation movement, it rotates a minimum fraction of rotation depending on the voltage, frequency and / or time between pulses that are determined by the signal.
    As an electrical signal generator, any electronic circuit that digitizes the electrical signals at the desired frequencies can be used. Another example of an electrical signal generator, used in the experimental designs of the present invention, can be an oscilloscope, since it allows to emit an electrical signal with a variable voltage over a given time.
    "Biocompatible material" means a material whose composition does not interfere or degrade the biological medium in which it is used. These materials are often used to make devices or elements thereof that must be in direct, brief or prolonged contact with the tissues and internal fluids of the body such as probes, syringes, prostheses, etc. An example of this material is polylactic acid (PLA).
    We will call "contact element" the part or element located in the distal part
    or earlier of the emitter or receiver and that comes into contact with the specimen on which the wave is intended to be transmitted. Preferably, the superstition of the contact element that comes into contact with the specimen should approximate the curvature of the lumen section to allow adequate transmission of the wave. Also preferably, the contact element of a transmitter or receiver will be made of a material with an acoustic shear impedance between the impedance
    Shear acoustics of the piezoelectric elements and that of the specimen in order to maximize the energy of the waves that will be emitted on it.
    We will call "shear acoustic impedance" at the value Zs determined by the equation
    Where Zs is the acoustic shear impedance at a given volume of the propagation medium, p is the density, and it is the velocity of the shear wave at the same determined volume of the propagation medium.
    10 Probe of the invention
    In the defined context, a first aspect of the invention consists of a transluminal or intraluminal probe to characterize the spatial distribution of mechanical parameters of a specimen, hereinafter "the device or probe of the invention", which
    15 comprises at least one emitter of S waves or P and S waves, preferably shear waves, more preferably axisymmetric waves, hereinafter "wave emitter", and at least one wave receiver, in which the receiver or receivers they are arranged concentrically and the arrangement of the emitters and receivers allows them to enter, simultaneously, in direct contact with the specimen.
    In particular, the device of the invention can generate axisymmetric waves at different frequencies by controlling the electrical excitation. The device can generate waves comprising frequencies ranging from 1 Hz to 50 MHz depending on the dimensions and materials of the specimen.
    In a particular embodiment, the probe of the invention comprises at least one concentrically located wave emitter. In a preferred embodiment, the probe comprises a single wave emitter located concentrically.
    In another particular embodiment, at least one wave emitter, preferably each wave emitter, comprises a contact element connected to an electromechanical actuator.
    In a preferred embodiment, at least one wave emitter, preferably each emitter, comprises a disc-shaped or cylindrical contact element attached to an electromagnetic device that converts electrical signals into rotational motion, such as an electromagnetic micromotor. An example of this type of issuers can be found in the application WO / 2017/009516.
    5 In a preferred embodiment in which the probe of the invention comprises an emitterof waves which in turn comprise a disk-shaped contact element orcylindrical attached to an electromagnetic device capable of converting electrical energyin a rotation movement, the union of the contact element to the device thatprovides the rotation movement is performed by a flexible shaft with a
    10 length greater than 5 cm, preferably greater than 25 cm and more preferably greater than 30 cm, which moves the induced rotation movement, allowing said electromagnetic device to be located outside the conduit or vessel into which the distal part of the probe and its diameter can be reduced.
    15 In another particular embodiment [Fig. 2], at least one wave emitter comprises at least one piezoelectric element (Pz), preferably two or more piezoelectric elements, fixed to the inside of a contact element (C) with a substantially toroidal shape whose axis of revolution coincides with center in the longitudinal axis of the probe (O) and the polarization of the piezoelectric element or elements allows transforming a signal
    20 electric in a rotation movement with tangential direction (T) to the outer surface of the contact element.
    In another particular embodiment at least one wave receiver, preferably each receiver, comprises a contact element attached to at least one element
    25 piezoelectric so that when a wave reaches a receiver, the contact element resonates and deforms the piezoelectric elements producing an elastic signal coupled with its voltage state.
    In another particular embodiment [Fig. 3], at least one receiver, preferably each
    The receiver comprises at least one piezoelectric element (pz) fixed to the inside of a contact element (C) with a substantially toroidal shape whose axis of revolution coincides with the center on the longitudinal axis (O) of the probe and the polarization of the element O piezoelectric elements allows to transform a rotation movement with tangential direction (T) to the outer surface of the contact element in an electrical signal.
    Preferably, [Fig. 4], the contact elements (C) of the wave receivers are segments of a cylinder or a toroid whose axis of revolution coincides with the center on the longitudinal axis (O) and whose piezoelectric element (pz) is fixed inside. with a polarization that allows to transform a rotation movement with direction
    5 tangential (T) to the outer surface of the contact element in an electrical signal.In this way, a set of k receivers is arranged, with le1, preferably k2: 2,more preferably k = 4, located in the same position of the longitudinal axis of theprobe. Increasing the number k of receptors ensures that the probe is moresensitive to the three-dimensional heroicity of the specimen.
    In another particular embodiment the probe of the invention comprises a single wave emitter located between the contact element and the receivers. In a preferred embodiment, the single emitter comprises a contact element with a cylindrical shape attached to an electromagnetic device that provides the rotational movement and
    15 which is located between the contact element and the receivers.
    In another particular embodiment, the contact element of at least one wave emitter, preferably the contact element of each emitter, is cylindrical in shape and has a plurality of holes that facilitate the suction of the air between the probe and the
    20 vessel wall or duct so that there is no separation between the receptors and the tissue.
    In a particular embodiment, the probe of the invention comprises at least 2, preferably at least 3, concentrically located receivers.
    In another preferred embodiment, the probe of the invention comprises j sets or blocks of receivers, being) '2: .2, so that the j sets of receivers are aligned along the longitudinal axis of the probe (Fig. 5].
    More preferably, the probe of the invention comprises j sets of k receptors, where j :. 2 and k :. 2, more preferably) !. 2 and k2: 3 And even more preferred,) '2: .3 and / (> 3,
    More preferably, the contact elements of each set of receivers 35 are segments of the same cylinder or of a toroid whose axis of revolution coincides with center in the longitudinal axis. In a specific embodiment, each of these segments is connected to a piezoelectric element so that all the piezoelectric elements of each set of receivers have the same polarization in a direction tangent to the outer surface of the cylinder or toroid.
    Ideally, both the emitters and the receivers have to be in contact with the specimen, so that in another particular embodiment, the probe of the invention is covered by a protective layer, preferably made of a hydrophobic material, preferably with a thickness of between 30 and 60 microns, so that
    10 contact elements will be separated from the specimen only by this layer for hygienic purpose without attenuating the signal or introducing interference. Preferably, this protective layer will be disposable.
    In another preferred embodiment, the device of the invention comprises means that
    15 allow the air existing between the surface of the probe and the wall of the vessel or duct to be sucked so that there is no separation between the receptors and the tissue. By extension, these means for sucking the air can be part of another device that is used in an auxiliary manner to facilitate elastographic analysis. An example of these means consists of a vacuum pump, a peristaltic pump or a syringe.
    The probe of the invention is completed with means suitable for transmitting the electrical signals that induce the movement of the emitters and receive the signals captured by the receivers, as well as means that allow the storage and processing of data obtained with the probe.
    Method for obtaining useful data for elastographic analysis
    Thus, the invention relates to a method, hereinafter "method of the invention" for obtaining useful data to characterize the spatial distribution of mechanical parameters of a specimen, in particular elastographic analysis of the specimen, preferably obtaining parameters useful as biomarkers, comprising the emission of P and / or S waves, preferably shear waves, more preferably axisymmetric waves, and the extraction of mechanical constants from the reception of reflected waves from a probe located inside a vessel
    35 or duct of the specimen.
    In a particular embodiment, the method of the invention emits and receives the waves by means of the probe of the invention.
    5 The extraction of constants or mechanical parameters, in particular useful parameters such as biomarkers, that govern the propagation of the waves from the waveform in the time recorded by the receiver can be done through a mere calculation of flight time to from the beginning of the signal in time, to an inverse problem based on propagation models simulated by semianalytical or numerical methods.
    In particular, the method consists of introducing a probe capable of emitting axisymmetric waves and receiving the reflected waves, preferably the probe of the invention, by a vessel or conduit, such as an artery or, preferably, the urethra until reaching the position closest to the area of the specimen to be analyzed,
    15 emit shear waves, preferably axisymmetric, and collect the signal from the re-emitted wave. [Fig. 6)
    In a particular embodiment, the process comprises a previous stage in which the gas or fluid existing inside the duct is suctioned to maximize the
    20 contact surface between the walls of the duct and the contact elements of the probe of the invention [Fig. 7], thus allowing a better propagation of the emitted and received waves.
    In a preferred embodiment, the method of the invention is a method for performing transurethral elastography analysis for the diagnosis of prostate cancer and monitoring thermal ablation as a focused therapy of prostate cancer.
    Procedure of reconstruction of elastographic parameters
    Elastographic parameters can be reconstructed from the signals received by the receivers of the probe of the invention by any of the methods described in the state of the art as optimization methods, such as Genetic Algorithms, or others of different nature such as Reverse -Time Migration widely
    35 employed in geophysics.
    In a particular embodiment, the movement induced by each emitter can be decomposed into a pseudo-spherical source of shear waves, minimizing the emission of compression waves. Subsequently a genetic algorithm is used that
    5 optimize a cost function whose variables are the mechanical parameters to be quantified. Other complementary methods such as Reverse-Time Migration can help reduce the size of the optimization domain of the Genetic Algorithm.
    10 The physical principle is based on the interaction between the transmitted shear waves and the internal mechanical structure of the specimen of interest. As an example, use the application for the diagnosis of prostate cancer and the monitoring of prostate-focused ablation. The shear waves propagated within the prostate tissue will be altered by the presence of stiffer lesions than the surrounding tissue. Both most of
    15 Prostate tumors as a tissue treated by thermal ablation have a high stiffness in reference to normal prostate tissue. These elastic tissue changes generate reflections of the waves, which are detected by the probe, and that, thanks to their treatment and the application of inversion methods, parameters of these lesions can be reconstructed, such as elastic modulus, viscosity, size and
    20 location.
    MODE OF INVENTION
    In a first embodiment, the probe of the invention comprises:
    • A single axisymmetric wave emitter [Fig. 4] formed by a contact element (C) made of PLA and shaped like a bull with a square section attached to 4 piezoelectric elements (pz) fixed inside in equidistant positions, so that the rotational movement (T) of the element of
    The contact is induced by said piezoelectric elements.
    • A set of 4 receivers [Fig. 5], each formed by a contact element (C) whose shape is a section of about 800 of a 1 mm thick PLA cylinder and attached to a piezoelectric element (pz) on its inside.
    In a second embodiment [Fig_ 8], wave reception is achieved by 4 sets of receivers located equidistant along the longitudinal axis of the probe (O), in which each set is formed of 4 receivers located with an identical angle between each of them, in which each receiver is
    5 formed by a contact element (C) whose shape is a section of about 80 ° of a 1 mm thick PLA cylinder and attached to a piezoelectric element (pz) on its inside.
    In a third embodiment (Fig. 9), the probe of the invention comprises:
    10 • A single axisymmetric wave emitter formed by a contact element made of PLA and shaped like a disk attached to an electromagnetic motor connected to an oscilloscope.
    • A set of 4 receivers [Fig. 5], each formed by a contact element (C) whose shape is a section of about 80 ° of a PLA cylinder
    15 with 1 mm thick and attached to a piezoelectric element (pz) on the inside.
    The probes described as examples are completed with electronics capable of exciting the transmitter and conditioning and digitizing the reception, the software capable of implementing
    20 the management and analysis interface, as well as the structure and housing capable of housing the above elements with hygienic and ergonomic conditions.
    Experimental results
    Using the prototype described in the third embodiment, with a receiver comprising a contact element formed 4 ring sectors connected to 4 piezoelectric elements and a single electromechanical wave emitter with a disk design emitter, on a gel-simulated prostate 13% sigma-aldrich on water,
    30 the following results of measured signals have been obtained [Fig. 10], which allow us to validate the prototype against simulated signals using finite differences using the theory of linear elasticity simulating the same configuration [Fig. 11], are compatible with the experimental ones. thus preliminary validating the functionality of the prototype.
    权利要求:
    Claims (14)
    [1]
    1.-Transluminal or intraluminal probe to characterize the spatial distribution of mechanical parameters of a specimen, which comprises at least one wave emitter
    5 S or P and S waves, and at least one wave receiver, in which the receiver orreceivers are arranged concentrically and the arrangement of the emitters andreceivers allow them to enter, simultaneously, in direct contact with the specimen.
    [2]
    2. Probe according to the preceding claim comprising at least one emitter of shear waves 10, preferably axisymmetric waves.
    [3]
    3.-Probe according to the preceding claim characterized in that at least one wave emitter is located concentrically.
    4. Probe according to the preceding claim comprising a single wave emitter.
    [5]
    5. Probe according to any of the preceding claims characterized in that at least one axisymmetric wave emitter comprises a contact element with a disk or cylindrical shape attached to an electromagnetic device that converts signals
    20 electric rotating motion.
    [6]
    6.-Probe according to the preceding claim by which the contact element is connected to the device that provides the rotation movement by means of a flexible shaft with a length greater than 5 cm, preferably greater than 25 cm and more preferred
    25 greater than 30 cm, which moves the induced rotation movement.
    [7]
    7. Probe according to any of the preceding claims in which the contact element of at least one axisymmetric wave emitter, preferably each contact element of the emitters, is cylindrical in shape and has a plurality of holes
    [8]
    8. Probe according to any of claims 1 to 4 or 7 characterized in that at least one emitter comprises at least one piezoelectric element, preferably two
    or more piezoelectric elements, fixed to the inside of a contact element
    With a substantially toroidal shape whose axis of revolution coincides with the center on the longitudinal axis 35 of the probe and the polarization of the piezoelectric element or elements allows the transformation of an electrical signal into a rotational movement with a tangential direction to the outer surface of the contact element. 9. Probe according to any of the preceding claims, wherein at least one receiver, preferably each receiver, comprises a contact element attached to the
    5 less to a piezoelectric element so that when a wave reaches a receiver,the contact element resonates and deforms the piezoelectric elementsproducing an elastic signal coupled with its tension state.
    [10]
    10.-Probe according to the preceding claim wherein at least one receiver,
    10 preferably each receiver, comprises at least one piezoelectric element fixed to the inside of a contact element with a substantially toroidal shape whose axis of revolution coincides with the center in the longitudinal axis of the probe and the polarization of the element or piezoelectric elements allows transforming a rotation movement with tangential direction to the outer surface of the contact element in a signal
    15 electric.
    [11 ]
    11. Probe according to claim 9 wherein the contact elements of the wave receivers are segments of a cylinder or a toroid whose axis of revolution coincides with the center on the longitudinal axis and whose piezoelectric element is fixed inside
    20 with a polarization that makes it possible to transform a rotation movement with a tangential direction to the outer surface of the contact element into an electrical signal.
    [12]
    12. Probe according to any of the preceding claims comprising at least 2, preferably at least 3, concentrically located receivers.
    13. Probe according to the preceding claim comprising j sets or blocks of receivers, with J ' ! 2, such that the j sets of receivers are aligned along the longitudinal axis of the probe.
    14. Probe according to the preceding claim comprising j sets of k receptors, where j !:. 2 and / e2. more preferably j !:. 2 y / e3 And even more preferred, J !. 3 y / e3.
    [15]
    15. Probe according to any of the preceding claims comprising means that allow suction of the air between the surface of the probe and the wall of the vessel or duct so that there is no separation between the receptors and the specimen.
    [16]
    16.-Procedure for obtaining useful data to characterize the spatial distribution of mechanical parameters of a specimen comprising the emission of S waves or P and S waves, and the reception of reflected waves from a probe
    5 located inside a glass or duct.
    [17]
    17. Method according to the preceding claim, characterized in that the emitted waves are shear waves, preferably axisymmetric waves.
    18. A method according to any of claims 16 or 17 comprising a previous stage in which the gas or fluid existing inside the duct is suctioned to maximize the contact surface between the duct walls and the probe. 19.-Method according to any of claims 16 to 18 using a
    15 probe according to claims 1 to 15.
    [20]
    20. Method according to any of claims 16 to 19 for the diagnosis of prostate cancer.
    20 21. Method according to any of claims 16 to 19 for monitoring thermal ablation as a focalized therapy of prostate cancer.
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    同族专利:
    公开号 | 公开日
    WO2018172591A1|2018-09-27|
    ES2687485B1|2019-07-31|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    WO2022034237A1|2020-08-14|2022-02-17|Universidad De Granada|A medical apparatus for the non-invasive transmission of focussed shear waves to impact cellular behaviour|US20130102932A1|2011-10-10|2013-04-25|Charles A. Cain|Imaging Feedback of Histotripsy Treatments with Ultrasound Transient Elastography|
    US10624609B2|2012-10-07|2020-04-21|Mayo Foundation For Medical Education And Research|System and method for shear wave elastography by transmitting ultrasound with subgroups of ultrasound transducer elements|
    US9420996B2|2014-01-30|2016-08-23|General Electric Company|Methods and systems for display of shear-wave elastographyand strain elastography images|
    CN104055541A|2014-06-26|2014-09-24|中国科学院苏州生物医学工程技术研究所|Method for intravascular ultrasound multi-slice shear wave elastography|
    WO2016001783A1|2014-06-30|2016-01-07|Koninklijke Philips N.V.|Ultrasound shear wave elastography featuring therapy monitoring|
    JP6415920B2|2014-10-06|2018-10-31|キヤノンメディカルシステムズ株式会社|Ultrasonic diagnostic equipment|
    CA2971676A1|2014-12-24|2016-06-30|Super Sonic Imagine|Shear wave elastography method and apparatus for imaging an anisotropic medium|
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    PCT/ES2018/070243| WO2018172591A1|2017-03-24|2018-03-26|Transluminal device and method for the mechanical characterisation of structures|
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