• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Emulsion and procedure for its manufacture. The invention relates to an emulsion containing a mixture of aqueous and oil phases, wherein the aqueous phase comprises sea water, a viscosity and a humectant, and wherein the oil phase comprises: polyglyceryl, hectorite, propylene carbonate, t-butyl alcohol, a crospolymethyl polyacrylate-6, at least one viscosity, at least one emulsifier, at least one co-emulsifier and at least one emollient, so that the phases forming the emulsion are stabilized. It is also the object of the present invention the manufacturing process that allows to obtain the emulsion with sea water detailed above. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2614725A1
    申请号:ES201730139
    申请日:2017-02-07
    公开日:2017-06-01
    发明作者:Juan Ramón GARCÍA GÓMEZ；Jorge DÍAZ-CRESPO CARDONA
    申请人:Blue Sea Laboratories S L；Blue Sea Laboratories SL；
    IPC主号:
    专利说明:

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    D E S C R I P C I O N
    OBJECT OF THE INVENTION
    The present invention relates to a stabilized emulsion that has been made with seawater, the purpose of which is to enable topical application in an easy and rapid absorption manner, providing the skin with the emolliency properties of the hydrolipldic emulsion and reinforcement of the Barrier effect with acceleration of the natural process of skin repair offered by seawater.
    Thus, the emulsion contains a mixture of an aqueous and an oily phase, where the aqueous phase comprises, among other elements, seawater, a viscosifier and a humectant, and where the oil phase comprises, among other elements, polyglyceryl, hectorite. , propylene carbonate, t-butyl alcohol, crospollmero-6 polyacrylate.
    The object of the invention is to achieve a light and stable emulsion, both physically and microbiologically, with beneficial properties due to the presence of seawater.
    BACKGROUND OF THE INVENTION
    The properties of seawater in the field of dermatological cosmetics and its palliative effects of certain symptoms of skin conditions such as psoriasis, dermatitis, acne and eczema in general are well known in the state of the art. These properties come from its mineral composition rich in trace elements such as magnesium, bromine, selenium, strontium, potassium and calcium, among others, which, due to their ability to reduce the increase in transepidermic water loss, provide us with the reinforcement of the barrier effect, hydration and acceleration of the natural skin repair process.
    The different cosmetic skin treatment products can be presented at
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    final consumer under multiple cosmetic forms, such as serlociones, powder, etc. An especially advantageous cosmetic form is emulsions, since they are easy to apply thanks to their light texture, rapid absorption and because they offer an immediate sensation of comfort in the skin after application.
    More specifically, an emulsion is a mix of two liquids immiscible in a more or less homogeneous way. One of these liquids constitutes the dispersed phase and the other constitutes the dispersing or continuous phase. To give rise to the emulsion, the dispersed phase is dispersed in the dispersing phase, the addition of an emulsifying agent or surfactant being sometimes necessary to provide emulsion stability.
    The main problem to be solved during the preparation of emulsions is, precisely, their stability, understood as the ability of the emulsion to maintain the homogeneous mixture of the aqueous phase and the oil phase, without physical separation thereof.
    Additionally, this problem is exacerbated if the emulsions contain an aqueous phase based on seawater or brine, since the high concentrations of typical salt of these aqueous phases cause the separation of the phases.
    Documents such as patent no. ES2593682T3 or patent num. JP11228377 disclose cosmetic emulsions of oil in water that are stable, however, they do not solve the problem of emulsion stability associated with a phase with a high concentration of salts, such as seawater.
    The invention proposed herein solves the problem described above, by offering an emulsion composition that combines cosmetics and therapeutics in relation to the relief of symptoms of a seawater skin disease with high stability, both physical and microbiological. and the method of obtaining it.
    DESCRIPTION OF THE INVENTION
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    The emulsion object of the invention comprises the mixture of two phases, specifically an aqueous phase and an oil phase, where the aqueous phase comprises seawater.
    In this way, the emulsion will be obtained by mixing, on the one hand, all the water-soluble components to obtain the aqueous phase and, on the other hand, all the oil-miscible components, in the presence of an emulsifying agent.
    Thus, in the aqueous phase of the present invention, in addition to seawater, at least one viscosifier and at least one humectant are present, while the oil phase comprises polyglyceryl, hectorite, propylene carbonate, t-butyl alcohol, polyacrylate crospollmero-6, at least one viscosifier, at least one emulsifier, at least one coemulsifier and at least one emollient. In this way, the elements that make up the different phases allow the formation of an emulsion of homogenous stabilized phases and without being separated from each other.
    Thus, the amount of seawater present in the aqueous phase is in a range of between 1% and 90% (w / w) relative to the total amount of emulsion. Obviously, the higher the percentage of seawater, the higher the electrolyte content and, therefore, the greater the difficulty of mixing the phases to achieve homogenization and maintain its stability.
    On the other hand, the maximum percentages of polyglyceryl, hectorite, propylenecarbonate, t-butyl alcohol and the crospollmero-6 polyacrylate contained in the oil phase have a maximum percentage of 20% (w / w) each relative to the total amount of the emulsion.
    Next, the preferred components for the viscosifier, humectant, emollient and coemulsifier are detailed in order to obtain the emulsion of the invention:
    - Among the viscosizers usable in the aqueous phase and in the oil phase, at least one component selected from the following group can be used: an acrylamide copolymer, an acrylate copolymer, an acrylic acid copolymer, xanthan gum, a polyglyceryl methacrylate, a carbomer and hydroxyethyl cellulose.
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    - Among the humectants of the aqueous phase, at least one component selected from the following group can be used: glycerin, propylene glycol, sorbitol, pentaerythrol, polyglycerols and polyethylene glycols.
    - Among the emollients of the oil phase, at least one component selected from the following group can be used: isopropyl palmitate, isopropyl myristate, oleyl oleate, isostearyl isostearate, decyl oleate, glyceryl stearate and caprylate of diglyceride.
    - Among the coemulsifiers of the oil phase, at least one component selected from the following group can be used: cetllic alcohol, lauryl alcohol, stearic alcohol, oleic alcohol, cetearyl glucoside and ceteareth-12.
    The difficulty of the present invention lies in obtaining a mixture of the stable phases in order to offer a product whose composition and presentation lasts over time, in a homogeneous way, without separation of the phases, keeping all its properties unalterable. For this, it will be necessary for the emulsion to be obtained by the following manufacturing process:
    a) Preparation of an aqueous phase.
    At this stage it is sought to increase the viscosity of seawater by mixing it with a viscosifier and a humectant. In this way the mobility of the droplets of the aqueous phase is reduced, making the clash of one another more difficult.
    The formation of the aqueous phase is obtained by the following steps:
    - Introduction in a seawater reactor, a viscosifier and a humectant.
    - Agitation of seawater, viscosifier and humectant at a rate of at least 10 R.P.M. for at least 20 minutes and at a temperature between 50 ° C and 90 ° C,
    - Homogenization of seawater, viscosifier and humectant at a speed of at least 1500 R.P.M. for at least 20 minutes and at a temperature between 50 ° C and 90 ° C.
    b) Preparation of an oil phase.
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    At this stage an emulsifying system is selected that is stable against a significant amount of electrolytes (present in seawater). To do this, the use of surfactants is used, which when used to stabilize an emulsion are called emulsifiers and allow the surface tension of the phase obtained to be reduced. Preferably, this stage is carried out in a fuser because it is a vessel with temperature input, where the elements involved in the oil phase are heated and melted.
    The formation of the oil phase is obtained by the following stages:
    - Introduction in a polyglyceryl, hectorite, propylene carbonate, t-butyl alcohol, crospollmero-6 polyacrylate, at least one viscosizer, at least one emulsifier, at least one coemulsifier and at least one emollient.
    - Agitation of polyglyceryl, hectorite, propylene carbonate, t-butyl alcohol, crospollmero-6 polyacrylate, at least one viscosifier, at least one emulsifier, at least one coemulsifier and at least one emollient at a rate of at least , 10 RPM for at least 20 minutes and at a temperature between 50 ° C and 90 ° C,
    c) Following are the conditions conducive to the formation of the emulsion.
    In this way, the mechanical emulsification work allows the masses of the phases to be divided by mechanically overcoming their surface tension.
    For this, the temperature will be an essential parameter by directly influencing the surface tension. In this way, in the case at hand, as the temperature increases, the surface tension, the interfacial tension and the viscosity will decrease, favoring the emulsion between the phases.
    Addition of the oil phase on the aqueous phase and stirring at a rate of at least 10 R.P.M. for at least 10 minutes and at a temperature between 50 ° C and 90 ° C. Subsequently, homogenization is performed at a rate of at least 1500 R.P.M. for at least 10 minutes and at a temperature between 50 ° C and 90 ° C, obtaining a homogeneous emulsion with physical stability.
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    d) Microbiological stabilization of the emulsion.
    To this end, components such as caprilyl glycol and caprylic hydroxamic acid are added to the emulsion obtained in phase c) to provide it with microbiological stability, it being recommended that the emulsion be at a temperature between 20 ° C and 40 ° C.
    In this way, the combination of the elements mentioned above and their mixture, following the procedure described, allows to obtain an emulsion whose oily and aqueous phases are homogeneous and stable between them.
    The main advantage of the emulsion of the invention is the presence of seawater among the elements of its composition, so it is possible to easily apply a mixture on the skin of light texture and rapid absorption that offers proven improvements in the field of cosmetics dermatological and certain symptoms of skin conditions such as psoriasis, dermatitis, acne and eczema in general. These properties come from its mineral composition rich in trace elements such as magnesium, bromine, selenium, strontium, potassium and calcium, among others, which, due to their ability to reduce the increase in transepidermic water loss, provide us with the reinforcement of the barrier effect, hydration and acceleration of the natural skin repair process.
    EXAMPLE OF PREFERRED EMBODIMENT
    Next, the preferred manufacturing process that allows obtaining the emulsion of the invention is detailed:
    - Seawater, a copolymer of acrylamide and propylene glycol are mixed in a reactor, stirring for 25 minutes at a blade speed of 12 R.P.M. and with a temperature of 70 ° C.
    Then the working speed is raised to 2000 R.P.M. for 25 minutes for homogenization of the aqueous phase obtained.
    - The following components are mixed in a fusora: polyglyceryl, hectorite,
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    propylenecarbonate, t-butyl alcohol, crospollmero-6 polyacrylate, a copolymer of acrylamide as a viscosifier, isopropyl myristate as an emollient, cetyl alcohol as a coemulsifier and stirring with a speed of 15 R.P.M. for 25 minutes and with a working temperature of 70 ° C to obtain the oil phase
    - Next, the oil phase on the aqueous phase is added in a reactor maintaining an agitation of 15 R.P.M. for 20 minutes and at a temperature of 70 ° C, then homogenization is carried out at a speed of 2000 R.P.M. for 20 minutes and at a temperature of 70 ° C, obtaining a homogeneous emulsion with physical stability.
    - Finally, in order to obtain the microbiologically stabilized emulsion, the following components are added to the emulsion obtained in the previous stage: caprilil glycol and caprilhydroxamic acid at a temperature of 25 ° C.
    权利要求:
    Claims (9)
    [1]
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    R E I V I N D I C A C I O N E S
    1. - Emulsion, characterized in that it contains a mixture of an aqueous phase and an oil phase, where the aqueous phase comprises seawater, a viscosifier and a humectant, and where the oil phase comprises polyglyceryl, hectorite, propylene carbonate, t-butyl alcohol, crospollmero-6 polyacrylate, a viscosifier, an emulsifier, a coemulsifier and an emollient, and where the emulsion is stabilized, homogeneous and without separation between the phases.
    [2]
    2. - The emulsion according to claim 1, characterized in that the amount of seawater present in the aqueous phase is in a range of between 1% and 90% (w / w) in relation to the total amount of emulsion.
    [3]
    3. - The emulsion, according to claim 1, characterized in that the seawater of the aqueous phase has a brine form with a boron content of less than 1mg / l, is free of organic components, bacteria and macromolecules larger than 0 , 1 py has a pH higher than 8.2.
    [4]
    4. - The emulsion according to claim 1, characterized in that the polyglyceryl, hectorite, propylene carbonate, t-butyl alcohol and crospollimer-6 polyacrylate have an amount each not exceeding 20% (w / w) in relation to The total amount of emulsion.
    [5]
    5. - The emulsion, according to claim 1, characterized in that the viscosifier of the aqueous phase and the oil phase is at least one component selected from the group consisting of an acrylamide copolymer, an acrylate copolymer, a copolymer of acrylic acid, xanthan gum, a polyglyceryl methacrylate, a carbomer and hydroxyethyl cellulose.
    [6]
    6. - The emulsion, according to claim 1, characterized in that the humectant of the aqueous phase is at least one component selected from the group consisting of propylene glycol, sorbitol, glycerin, pentaerythrol, polyglycerols and polyethylene glycols.
    [7]
    7. - The emulsion according to claim 1, characterized in that the oil phase emollient is at least one component selected from the group consisting of palmitate
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    of isopropyl, isopropyl myristate, oleyl oleate, isostearyl isostearate, decyl oleate, glyceryl stearate and diglyceride caprylate.
    [8]
    8. - The emulsion, according to claim 1, characterized in that the coemulsifier of the oil phase is at least one component selected from the group consisting of kettle alcohol, lauryl alcohol, steary alcohol, oleic alcohol, cetearyl glucoside and ceteareth- 12.
    [9]
    9. - Procedure for the farication of an emulsion, which comprises the following steps:
    a) Preparation of an aqueous phase comprising the steps of:
    - introduction into a seawater reactor, a viscosifier and a humectant,
    - agitation of seawater, viscosifier and humectant at a rate of at least 10 R.P.M. for at least 20 minutes and at a temperature between 50 ° C and 90 ° C,
    - homogenization of seawater, viscosifier and humectant at a rate of at least 1500 R.P.M. for at least 20 minutes and at a temperature between 50 ° C and 90 ° C.
    b) Preparation of an oil phase comprising the stages of:
    - introduction into a fuser of polyglyceryl, hectorite, propylene carbonate, t-butyl alcohol, crospollmero-6 polyacrylate, at least one viscosifier, at least one emulsifier, at least one coemulsifier and at least one emollient.
    - stirring of the polyglyceryl, hectorite, propylene carbonate, t-butyl alcohol, crospollmero-6 polyacrylate, at least one viscosifier, at least one emulsifier, at least one coemulsifier and at least one emollient at a rate of at least , 10 RPM for at least 20 minutes and at a temperature between 50 ° C and 90 ° C,
    c) addition of the oil phase on the aqueous phase and stirring at a rate of at least 10 R.P.M. for at least 10 minutes and at a temperature between 50 ° C and 90 ° C, then homogenization is carried out at a rate of at least
    1500 R.P.M. for at least 10 minutes and at a temperature between 50 ° C and 90 ° C, obtaining a homogeneous emulsion with physical stability, and
    d) addition to the emulsion obtained in phase c) of stabilizing components 5 selected from the group consisting of caprylic glycol and caprylic hydroxamic acid,
    at a temperature between 20 ° C and 40 ° C, to provide the emulsion with microbiological stability.
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    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    WO1999002128A1|1997-07-10|1999-01-21|Dead Sea Laboratories Ltd.|A skin care and protection composition and a method for preparation thereof|
    FR2794023A1|1999-05-28|2000-12-01|Codif Internat Sa|Cosmetic composition reinforcing efficiency of active agents of other cosmetic preparations comprises micro-emulsion whose aqueous phase is based on sea-water|
    US20090258085A1|2008-03-17|2009-10-15|Ahava- Dead Sea Laboratories Ltd.|Emulsions and methods of their production|
    JP4562213B2|1998-02-10|2010-10-13|株式会社資生堂|Oil-in-water emulsion composition|
    JP4406035B1|2008-07-09|2010-01-27|株式会社資生堂|Oil-in-water emulsified skin cosmetic|
    JP6630506B2|2015-07-16|2020-01-15|花王株式会社|Method for producing oil-in-water emulsion composition|
    法律状态:
    2017-10-18| FG2A| Definitive protection|Ref document number: 2614725 Country of ref document: ES Kind code of ref document: B1 Effective date: 20171018 |
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    ES201730139A|ES2614725B1|2017-02-07|2017-02-07|Emulsion and manufacturing procedure|ES201730139A| ES2614725B1|2017-02-07|2017-02-07|Emulsion and manufacturing procedure|
    US16/079,224| US10596189B2|2017-02-07|2018-01-29|Emulsion and method for the manufacture thereof|
    PCT/ES2018/070063| WO2018146354A1|2017-02-07|2018-01-29|Emulsion and method for the production thereof|
    EP18750776.9A| EP3581167A4|2017-02-07|2018-01-29|Emulsion and method for the production thereof|
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