• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Biopsy kit The present invention relates to a biopsy kit that has utility in the diagnostic process of oncological patients to direct biopsies in tissues with metabolic activity in studies with positron-emitting radiopharmaceuticals and in which no morphological alterations are visualized in structural radiological studies. It also allows increasing the profitability of punctures of structural lesions with different areas of metabolic activity. Solves the problem of guiding the biopsy needle with positron emission image without the need for conventional x-ray support image, since the elements that make up the kit are visible in the positron emission image. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2600870A1
    申请号:ES201531185
    申请日:2015-08-10
    公开日:2017-02-13
    发明作者:María Ángeles GARCÍA FIDALGO；Jesús CORTES RODICIO；Gaspar SÁNCHEZ MERINO；Ignacio TOBALINA LARREA
    申请人:Administracion General de la Comunidad Autonoma de Euskadi；
    IPC主号:
    专利说明:

    BIOPSY KIT
    D E S C R I P C I O N
    5 OBJECT OF THE INVENTION
    The present invention relates to a biopsy kit that has utility in the diagnostic process of oncological patients to direct biopsies in tissues with increased metabolic activity with positron emitting radiopharmaceuticals and in which morphological alterations are not visualized in structural radiological studies. It also allows to increase the profitability of punctures of structural lesions with different areas of metabolic activity by directing the puncture to the most metabolically active areas where there is a greater probability of the existence of a viable tumor.
    The object of the present invention is a biopsy kit that solves the problem of guiding the biopsy needle with positron emission image without the need for conventional support X-ray image, since the elements that form the kit are also visible in the positron emission image.
    20 BACKGROUND OF THE INVENTION
    Biopsy procedures that combine PET (positron emission tomography ”) and CT (x-ray) computed tomography”) techniques are known in the state of the art and are based on extraction of coordinates and 25 verification of the puncture through the morphological image of the CT, then merge this
    PET image.
    These procedures are valid as long as the patient's position between the PET image and the CT image is not modified, so that the fusion of both is correct.
    The international application WO2010 / 048309A2 discloses a method of rapid image reconstruction, which allows guiding almost in real time.
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    Said method uses a high resolution PET that immobilizes and fixes the tissue to be biopsied and locates the area to be biopsied due to its position relative to the detecting / immobilizing elements.
    In other embodiments, the above method is combined with a radioactively labeled biopsy device so that its position can be detected with the PET equipment, where the biopsy device must be inserted into the tissue, also presenting radioactive markers arranged inside the patient tissue
    Because the radioactive markers must be introduced into the tissue to be biopsied, the procedure becomes considerably more expensive, being also much more complex to carry out.
    It is also known the patent application US2007 / 0167749 relating to a method and a device for marking a region of interest and that is visible in the image of nuclear emission and positron emission.
    In the previous device, the radioactive source must be placed inside the tissue, near the area to be biopsied, presenting the same drawbacks as the previous document.
    The present invention solves all the above drawbacks by means of a biopsy kit that solves the problem of guiding the biopsy needle with positron emission image without the need for a conventional support X-ray image and without the need to provide the radioactive source in the inside the tissue to biopsy.
    DESCRIPTION OF THE INVENTION
    The present invention relates to a biopsy kit that is useful in the diagnostic process of oncological patients to direct biopsies in tissues with increased metabolic activity with positron emitting radiopharmaceuticals and in which morphological alterations in structural radiological studies are not visualized. It also allows to increase the profitability of punctures of structural lesions with different areas of metabolic activity and for other imaging techniques.
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    The biopsy kit includes:
    a) a stereotactic framework that parameterizes the patient's biopsy space using a spherical coordinate system, where the stereotactic framework comprises at least three first accommodation areas for accommodation in each of them of a marker and a second accommodation area for the housing of a biopsy needle attachable in the stereotactic frame, and
    b) a processing system to obtain the spherical coordinates of the area to be biopsied from at least one image of the markers.
    Preferably the markers are positron emitting sources, although they could also be radiopaque markers.
    Preferably, the stereotactic frame comprises a support where the first housing areas of the markers are arranged, a first goniometer for measuring a polar angle 9, which is rotatable with respect to the support around a vertical axis, a second goniometer for measurement of an azimuthal angle 0, which in turn comprises a rotating arc with respect to a horizontal axis, where the rotating arc comprises the second housing area, which is preferably a bushing for housing and guiding the biopsy needle.
    In this way, the coordinates of the three markers arranged in the stereotactic frame and the region to be biopsied are known, the spherical coordinates are obtained, ie, polar angle 9 and azimuthal angle 0, which orient the direction of the biopsy needle, and it obtains the depth of penetration or depth to which the biopsy needle must be introduced.
    Optionally, the biopsy needle comprises a housing for positioning a marker, which will allow the processing system to obtain the verification of the position of the needle, knowing the coordinates of the three markers arranged in the stereotactic frame, of the marker arranged in the biopsy needle and the depth of penetration obtained previously.
    Since the kit is marked and calibrated with specific markers, it is possible to perform the tissue biopsy by guiding it through the image of the markers, which allows the use of the kit both in those patients who do not have a structural radiological alteration that allows the biopsy to be guided, such as in those patients with radiological structural lesions
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    but with heterogeneous captation in the study with positrons, which would allow it to obtain a sample of an area of greater metabolic activity avoiding punctures of necrotic or hemorrhagic tissue that are not useful for histological diagnosis.
    In other words, the biopsy kit of the present invention allows tissue biopsies to be carried out where there is no radiological structural lesion and therefore are not distinguishable in X-ray imaging. Specifically, candidates for this type of biopsy are oncological patients with visible pathological uptake in the tomograph by positron emission in which the presence of viable tumor cells without anomalous radiological finding is suspected, or patients with masses with heterogeneous uptakes directing the biopsy to areas of greater metabolic activity, improving profitability avoiding non-diagnostic punctures.
    BRIEF DESCRIPTION OF THE DRAWINGS
    Figure 1 shows a perspective view of the stereotactic frame of the biopsy kit of the present invention.
    Figure 2 shows an elevation view of the stereotactic frame of the biopsy kit of the present invention.
    Figure 3 shows a sectional view A-A of Figure 2.
    Figure 4 shows an elevational view of the biopsy needle attachable in the stereotactic frame of the biopsy kit of the present invention.
    PREFERRED EMBODIMENT OF THE INVENTION
    The biopsy kit of the present invention will be described in detail below.
    The biopsy kit includes:
    a) a disposable stereotactic frame (1) that parameterizes the patient's biopsy space using a spherical coordinate system, where the stereotactic frame (1) comprises at least three first areas (2) of accommodation for
    the accommodation in each of them of a marker, which are positron emitting sources or radiopaque markers,
    b) a biopsy needle (3) attachable in the stereotactic frame (1), and
    c) a processing system to obtain the spherical coordinates of the area
    5 to biopsy from at least one image of the markers.
    The stereotactic frame (1) comprises a support (4) where the first three areas (2) of housing of the markers, support (4) comprising a reference indicator (5) are arranged.
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    The support (4) further comprises fixing means, preferably arranged on a lower face (6) of the support (4), which are preferably adhesive fixing means (not shown) for carrying out the fixation of the stereotactic frame (1 ) to the patient's body.
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    The stereotactic frame (1) also comprises a first goniometer (7) for the measurement of a polar angle 9, which is rotatable with respect to the support (4) around a vertical axis, a second goniometer (8) for the measurement of an angle azimuthal 0 fixed to the first goniometer (7), where the second goniometer (8) for the measurement of an azimuthal angle 0 comprises a 20 arc (9) movable with respect to the second goniometer (8) and rotatable with respect to a horizontal axis, where the The arch (9) comprises a bushing (10) for housing and guiding the biopsy needle (3) that is arranged symmetrically with respect to the support (4). Optionally, the arc (9) comprises a housing (14) for positioning a marker.
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    The bushing (10) for housing and guiding the biopsy needle (3) comprises a hole (12) through which the biopsy needle (3) moves.
    The biopsy needle (3) comprises a housing (11) for positioning a marker. In addition, the biopsy needle (3) comprises a graduated scale (13).
    权利要求:
    Claims (14)
    [1]
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    R E I V I N D I C A C I O N E S
    1. - Biopsy kit characterized by comprising:
    a) a stereotactic framework (1) that parameterizes the space of the patient to be biopsied by means of a spherical coordinate system, where the stereotactic framework (1) comprises at least three first housing areas (2) for accommodation in each of them a marker, and a second housing area for housing a biopsy needle attachable in the stereotactic frame, and
    b) a processing system to obtain the spherical coordinates of the area to be biopsied from at least one image of the markers.
    [2]
    2. - Biopsy kit according to claim 1 characterized in that it comprises a biopsy needle (3) attachable in the second housing area of the stereotactic frame (1).
    [3]
    3. - Biopsy kit according to any one of the preceding claims characterized in that the stereotactic frame (1) comprises a support (4) where the housing areas (2) of the markers are arranged, a first goniometer (7) for the measurement of a polar angle 9, which is rotatable with respect to the support (7) around a vertical axis, a second goniometer (8) for the measurement of an azimuthal angle 0, which in turn comprises a rotating arc (9) with respect to a horizontal axis, where the arc (9) comprises the second housing area which is a bushing (10) for housing and guiding the biopsy needle (3).
    [4]
    4. - Biopsy kit according to claim 3 characterized in that the second goniometer (8) is fixed to the first goniometer (7).
    [5]
    5. - Biopsy kit according to any of claims 3 or 4, characterized in that the bushing (10) for housing and guiding the biopsy needle (3) is arranged symmetrically with respect to the support (4).
    [6]
    6. - Biopsy kit according to any one of claims 3 to 5 characterized in that the sleeve (10) for housing and guiding the biopsy needle (3) comprises a hole (12) through which the biopsy needle moves ( 3).
    [7]
    7. - Biopsy kit according to any of claims 3 to 6 characterized in that the support (4) of the stereotactic frame (1) comprises a reference indicator (5).
    [8]
    8. - Biopsy kit according to any of claims 3 to 7 characterized in that the support (4) comprises means for fixing to the patient's body.
    [9]
    9. - Biopsy kit according to claim 8 characterized in that the fixing means are arranged on a lower face (6) of the support (4).
    10 10.- Biopsy kit according to claim 8 characterized in that the fixing means are
    adhesive fixing means.
    [11]
    11. - Biopsy kit according to any of claims 2 to 10 characterized in that the biopsy needle (3) comprises a housing (11) for positioning a
    15 marker.
    [12]
    12. - Biopsy kit according to any of claims 3 to 11 characterized in that the arch (9) comprises a housing (14) for positioning a marker.
    13. A biopsy kit according to any of claims 2 to 12 characterized in that the
    Biopsy needle (3) comprises a graduated scale (13).
    [14]
    14. - Biopsy kit according to any of the preceding claims characterized in that the stereotactic frame (1) is disposable.
    25
    [15]
    15. - Biopsy kit according to any of the preceding claims characterized in that the markers are positron emitting sources.
    [16]
    16. - Biopsy kit according to any of claims 1 to 14 characterized in that the markers are radiopaque markers.
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    同族专利:
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    ES2600870B1|2017-11-21|
    WO2017025653A1|2017-02-16|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    GB922007A|1959-06-19|1963-03-27|Thomas Joseph Connelley|Improvements in or relating to surgical instruments|
    US6122541A|1995-05-04|2000-09-19|Radionics, Inc.|Head band for frameless stereotactic registration|
    WO2001062134A2|2000-02-24|2001-08-30|V-Target Ltd.|A method and system for guiding a diagnostic or therapeutic instrument towards a target region inside the patient's body|
    US20050033315A1|2003-08-01|2005-02-10|Hankins Carol A.|Apparatus and method for guiding a medical device|
    US5196019A|1991-10-04|1993-03-23|Dlp, Inc.|Goniometer for needle placement|
    AU6818694A|1993-04-26|1994-11-21|St. Louis University|Indicating the position of a surgical probe|
    DE10029737B4|2000-06-23|2006-01-19|Mri Devices Daum Gmbh|Navigation of a medical instrument|
    WO2007056458A2|2005-11-07|2007-05-18|Vanderbilt University|Adjustable universal surgical platform|
    US8315689B2|2007-09-24|2012-11-20|MRI Interventions, Inc.|MRI surgical systems for real-time visualizations using MRI image data and predefined data of surgical tools|DE102017104302A1|2017-03-01|2018-09-06|Hubert Noras|Biopsy needle guide with pointer for easy angulation|
    法律状态:
    2017-11-21| FG2A| Definitive protection|Ref document number: 2600870 Country of ref document: ES Kind code of ref document: B1 Effective date: 20171121 |
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    优先权:
    申请号 | 申请日 | 专利标题
    ES201531185A|ES2600870B1|2015-08-10|2015-08-10|Biopsy kit|ES201531185A| ES2600870B1|2015-08-10|2015-08-10|Biopsy kit|
    PCT/ES2016/070575| WO2017025653A1|2015-08-10|2016-07-28|Biopsy kit|
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