• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Method for the automatic filling of containers for intravenous administration medication in a machine for the automatic preparation of intravenous medication. The invention provides a method for the automatic filling of containers for intravenous administration medication in a machine for the automatic preparation of intravenous medication, said containers comprising at least one fluid inlet connector closed by a stopper comprising an internal passage through, said machine comprising punch-injector means actuated by at least one actuator means disposed in said machine. Said method is characterized in that said punch carries out a puncture of one of the ends of said cap directly injecting said component inside said container. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2549462A1
    申请号:ES201431570
    申请日:2014-10-24
    公开日:2015-10-28
    发明作者:Naiara Telleria Garay；Ainara Fol Ruiz De Loizaga；Borja Lizari Illarramendi
    申请人:Kiro Robotics SL；
    IPC主号:
    专利说明:

    Method for automatic filling of containers for intravenous administration medication in a machine for automatic preparation of intravenous medication
    The present invention is directed to the machine sector for the automatic preparation of intravenous medication preferably used for cytostatic, cytotoxic and / or analgesic treatments, among others.
    Particularly, the present invention refers to a method used in said type of machines for the automatic preparation of intravenous medication comprising at least one robotic arm capable of preparing at least one mixture of intravenous administration medication automatically and without manual intervention. by the user.
    The machines for the automatic preparation of intravenous medication are known in the state of the art, such as for example in the PCT patent application WO 2012/172418 or in the Spanish patent application No. 201430745. Such type of machines allows, by means of the actuation of at least one actuator (which can be, for example,
    20 of mechanical, electromechanical or robotic type, among others), the preparation of specific medication resulting from the mixing of different intravenous administration base components, such as, for example, a type of drug and a type of solvent, in others.
    It will be understood, in the present invention, as an intravenous administration component or
    25 base component, any medication, substance or drug for intravenous administration in patients, as well as any necessary solvent used for mixing with at least one intravenous drug, substance or drug.
    The base components used to obtain said medication mixtures
    30 are originally stored in specific vials or bags, which are usually arranged in a specific area inside the machine. By means of a syringe supported and operated by the actuator of said machine, the volume of base component necessary for the desired medication mixture is removed and deposited in a tank adapted to store the mixture of said base component with other base components
    35 previously deposited for the same medication mixture.

    Said type of deposits where the final intravenous medication mixture is stored is called "infuser" or "cassette". Said type of deposits, once filled with a medication mixture, can be used directly for intravenous infusion of said mixture in patients in different treatments, mainly analgesic and / or cytostatic, which comprise long periods of intravenous administration (between 24 and 72 hours) without the need for hospitalization of patients.
    On the one hand, the type of "infuser" filling reservoir is a reservoir that comprises an elastomeric inflatable balloon connected to an infuser inlet port through which the different base components for the desired medication mixture are introduced. The base components of the mixture are introduced into the elastomeric balloon causing the latter to swell. Said input port consists of a ~ Luer Lock "female threaded closure type connection adapted for connection to all types of syringes and devices with male" Luer Lock "connection, allowing a tight and secure closure, avoiding leaks and risks of direct contact It should be noted that in the healthcare field, a syringe whose distal end is of the type comprising a "Luer Lock" type connection, said "Luer Lock ~" connection is called "male" type, while at the point where that said "Luer Lock ~ male connection is connected in conjugate is called the" Luer Lock "female type connection, such as, for example, said infuser inlet port. Additionally, said infuser comprises an outlet port connected to a tube for direct intravenous administration to the patient and allow intravenous infusion The elastomeric material of the infuser's balloon exerts a pressure on the mixing liquid contained therein generating a flow or more or less continuous output for a certain time. Finally, said type of infusers usually includes an infusion closure cap called "Luer Lock" that allows the infuser to be closed in an aseptic way and thus prevents the entry of bacteria or any unwanted component and / or fluid into the inside the tank.
    On the other hand, the "cassette" type reservoir is a reservoir comprising a bag inside connected to a single inlet / outlet port that is connected to an intravenous administration tube to the patient, whose distal end also comprises a connection of Type "luer Lock" female adapted for connection to all types of syringes and devices with male uLuer Lock "connection, allowing a tight and secure closure, avoiding leaks and risks of direct contact. Said type of deposits, during the intravenous administration procedure to the patient, connect through the tube

    administration with an electronic pump that controls the speed of the medication outflow.
    Methods of filling infuser or cassette type tanks known in the state of the art usually require, before and after each filling, a manual pre-connection and disconnection stage of the male uLuer Lock ~ connector of an injector (such as by example, a syringe) to the female uLuer Lock ~ connector of an infuser or cassette type tank. This connection allows a tight seal by means of threading between both uLuer Lock ~ connectors. Likewise, these two manual stages of connection and disconnection between the respective "Luer LockH" connectors of the injector and reservoir respectively are repeated each time it is required to inject a component into a reservoir by means of an injector. Additionally, once the corresponding component has been filled in inside the tank, it is also required to cover the "Luer LockH female connector of the tank manually with a closure plug of the uLuer Lock type", allowing to close the port of entry of the tank aseptically and thus prevent the entry of bacteria or any component and / or unwanted fluid inside the tank. Said manual connection and disconnection stages of the "Luer LockH" connectors, which are carried out by the sanitary personnel authorized to perform this type of operations, considerably slow down the filling and mixture of components in said type of deposits and make automation impossible due to the need d of a considerable sophistication of technology that does not exist today. Additionally, in the case of manual filling of elastomeric infuser type tanks, the elastomeric balloon exerts a pressure contrary to the force exerted by the medical personnel during the filling procedure of said type of infusers. Said resistance exerted by the elastomeric balloon usually causes injuries to the health personnel who periodically and very often perform said filling procedure of elastomeric infusers. In addition, due to the high degree of toxicity of the drugs used to carry out the required medications, the involvement of health personnel in phases or stages of the method of preparation of said medication, such as for example the stages of connection and disconnection of the respective "Luer Lock" connectors between the injector and the tank respectively or the manual filling of the infusers by syringes, such personnel may expose a risk of contact with said highly toxic drugs.
    Thus, it is convenient to find a solution to solve the aforementioned problems. In particular, an object of the present invention is to provide an efficient and automated method of filling intravenous administration tanks that

    allow to accelerate the filling procedure of said type of deposits avoiding manual steps and reducing the risk of contact of the sanitary personnel in the preparation of these products that are highly toxic.
    To solve the aforementioned problems, the present invention discloses a method for the automatic filling of at least one type of base component in at least one container comprising at least one fluid inlet connector, by means of at least some injection means with punch actuated by at least one actuator means arranged in a machine for the automatic preparation of intravenous solutions, characterized in that said punch carries out a puncture of a closure cap of the container adapted to be perforated and arranged in said fluid inlet connector of said container, allowing direct injection of said component into said container. Thus, by having a pierceable cap, it is possible to directly pierce it by means of an injector means, such as a syringe with a needle, and inject the base component directly into the tank, without the need for connections and disconnections between the injection means and the reservoir. Additionally, by proceeding in this way, it is possible to avoid the participation of health personnel and thus reduce possible injuries that occurred when carrying out manual procedures for injection of components into the infusers. Additionally, the present method allows to reduce the risk of contact of health personnel with said highly toxic drugs.
    Preferably, the fluid inlet connector and the closure plug are of the uLuer LockM type
    •
    Preferably, said container is of the type used for direct infusion in intravenous patients.
    Both in the infuser type container and in the "cassette" type container, during the filling method by means of automatic intravenous medication preparation machines according to the present invention, in some cases, component dose losses for the final mixture usually occur. they do not get inside the infuser or cassette and they are deposited in the form of dead volumes inside said perforable closure cap disposed in the fluid inlet connector of the container. Due to the fact that the dose control introduced in an infuser or cassette container is carried out by means of a gravimetric control by weighing (that is, using the density value of the

    base components to transform the calculated weighing measurements to volume and thus know the accuracy of the volume of dosed base component), the calculated weight of infuser or cassette comprising a dead volume of dose that will not be administered to the patient causes an error of Calculation of the dose volume that has been given to the patient. As is well known, in this type of treatment it is crucial and very important that the respective dose (by volume) of each base component that is intended to be used for mixing is exactly the dose that is finally deposited inside the type container infuser or Ucassette ~, which is then injected by infusion into the patient. Given that the magnitude of the doses used in this type of mixtures is usually of the order of milliliters (mi), an error in the dose of a base component for the mixture can cause irreversible consequences and even the death of the patient .
    For all of the above, preferably, after direct injection of said component into said container, the punch retracts into said cap and removes a dead volume of base component remaining inside said cap. Thus, in this way an efficient and automated method of filling intravenous administration tanks is achieved that allows to determine and know the exact volume of dose introduced of each base component in said deposit.
    Preferably, said container comprises at least one elastomeric inflatable balloon connected to said fluid inlet connector and also comprises at least one outlet port internally connected to said inflatable balloon and externally connected to a tube for intravenous administration by infusion to the patient.
    Preferably, said container comprises at least one bag connected to a fluid inlet and outlet connector connected in turn to a tube for intravenous administration by infusion to the patient.
    Preferably, the injection means consist of a syringe with a plunger. In said case, after the direct injection of said component into said container, the syringe moves back inside said cap and removes a volume of said base component remaining inside said cap, by means of the piston recoil. of said syringe.

    Preferably, the injector means consist of a bag comprising a base component, said bag being connected to a peristaltic pump that allows said component to be pumped through a silicone tube connected to said pump whose distal end is topped by a punch. Additionally, and to solve the 5 problems mentioned above, the present invention discloses a method for the automatic filling of at least one type of base component originally arranged in a first base container, in at least a second container for intravenous infusion comprising at least one fluid inlet closed with a closure plug, by means of the action of at least one actuator means arranged in a machine for the
    10 automatic preparation of intravenous solutions, said machine additionally comprising at least at least some injection means for transferring at least said base component from the first to the second container, said method comprising the following steps:
    15 (upon extraction of at least said base component from the first container by means of said injector means actuated by said actuator means;
    (b) weighing the syringe with at least said base component inside;
    (C) puncture of the closure cap disposed in the fluid inlet of the second container with a needle of said injector means;
    20 (dl injection of said base component into said second container;
    (and) extracting said needle from said second container;
    (F) weighing of the empty injector means;
    Said method is characterized in that during the needle extraction stage of said second container (step (e '), the actuator places the needle of the injector means inside the cap, and by retracting the plunger of said injector means, also actuated by the actuator, removes the volume of said base component remaining inside said closure cap, thus, after weighing said means
    30 injectors (step (f », by means of the corresponding calculation by gravimetry, the exact volume of doses that have been deposited inside the second reservoir can be known, which will subsequently be used for intravenous administration by infusion to the patient.
    Preferably, the base component may consist of a type of intravenous medication or a type of solvent.

    Preferably, the first container may be a vial comprising at least one type of intravenous medication or it may be a bag comprising at least one type of solvent.
    Preferably, said second intravenous infusion container comprises at least one elastomeric inflatable balloon connected to a fluid inlet port and at least one outlet port connected to a tube for intravenous administration by infusion to the patient.
    Preferably, said second intravenous infusion container comprises at least one bag connected to a fluid inlet and outlet port connected in turn to a tube for intravenous administration by infusion to the patient.
    Preferably, the actuator means arranged in a machine for the automatic preparation of intravenous solutions may consist of at least one actuator of the mechanical, electromechanical or robotic type, among others.
    For the best understanding of the invention, some drawings of a preferred embodiment thereof are attached for explanatory and non-limiting purposes.
    Figure 1 shows a perspective view of an infuser type container or reservoir together with a "Luer Lock" type closure cap used in the method according to the present invention.
    Figure 2 shows a longitudinal section of the "Luer Lock" type plug of Figure 1.
    Figure 3 shows a perspective view of a step of the method according to the present invention in which the infuser type tank of Figure 1 is filled by a syringe.
    Figure 4 shows an enlarged longitudinal section view of a detail of Figure 3, in which the insertion of the syringe needle into the Luer Lock type closure plug connected to the infuser type tank is detailed.

    Figure 5 shows a perspective view similar to that of Figure 3 of a step of the method according to the present invention in which the contents of the syringe have been emptied inside the infuser type reservoir.
    Figure 6 shows a perspective view similar to that of Figure 5 of a step of the method according to the present invention in which the syringe is arranged to remove the dead dose volume from the reservoir closure cap.
    Figure 1 shows a type of reservoir -1-for the storage of a mixture of intravenous administration medication according to the method of the present invention. Said type of tank illustrated in Figure 1 is called ~ infuser "or elastomeric infuser" and comprises in its interior an elastomeric balloon -13-inflatable which, as can be seen in Figures 3 to 6, is connected to a port of input -10-to the infuser -1-by which the different base components -7- are introduced for the desired medication mixture. Said input port -10- consists of a uLuer Lock type connection "female threaded closure adapted for connection to all types of syringes and devices with male" Luer Lock "connection, allowing a tight and secure closure, avoiding leakage and risks of direct contact As indicated above, in the healthcare field, a syringe whose distal end is of the type comprising a "Luer Lock" type connection, said "Luer Lock" connection is called Umacho type ", while the point at which said "Luer Lockn male" connection is connected in conjugate is called the "Luer Lock" female type connection, such as, for example, the said input port -10-of the infuser -1-. Additionally, said infuser -1-comprises an outlet port -12-, connected to an intravenous administration tube (not illustrated), for direct connection to the patient and thus allowing intravenous infusion of the medication mixture.Elastomeric material exerts a pressure on the mixing liquid it contains, generating a more or less continuous outflow to the patient for a certain time. As can also be seen in Figure 1, this type of tank usually uses a closure plug -2-, of the "Luer Lock" type, which allows to close the inlet port -10-to the infuser -1-and thus prevent the entry of bacteria or any component and unwanted fluid into the tank.
    As can be seen in Figure 2, said closure plug -2- "Luer Lock" consists of a -25-cylindrical body comprising an internal volume -240-opened by one of its ends whose internal surface comprises helical grooves -241-internal threading to engage with the input port -10-type uLuer Lock ~ through threading
    P201 431570
    corresponding conjugate, as can be seen in Figures 3 to 6. Additionally, said internal volume -240- comprises a cylindrical duct -21concentric to said volume -240- comprising an opening -21 '-by one of its ends and the opposite end of said conduit -21- coincides with the other end of the body -25- comprising a hole -22-. The interior -23-of said cylindrical conduit -21 is of the intern type between the end -21'- and the end -22- for the possible passage of fluids. Said cylindrical duct -21- has a diameter smaller than the diameter of the inlet port -10-of the infuser -1-, so that when closing the inlet port -10- by said closing plug -2-, the cylindrical duct - 21-penetrates the interior of the input port -10-while the input port is screwed inside the internal volume -240-, getting a tight seal of the input port -10-. The hole -22- may comprise a closure membrane capable of being pierced and penetrated by the needle -32- of the syringe
    -3-.
    For the method described in the present invention, an intravenous medication container or reservoir of the infuser type or also another type of intravenous medication reservoir can be used such as, for example, a "cassette" type tank (not shown). The type of reservoir usually includes a bag inside connected to a single inlet / outlet port that is connected to an intravenous administration tube for direct connection to the patient and whose distal end is also closed by a "Luer Lockn" type closure cap. as described above, allowing to close the input / output of the cassette. Said type of deposits, during the intravenous administration procedure to the patient, is connected through the administration tube with an electronic pump that controls the speed of the medication outflow.
    As explained above, the present invention refers to a method used in a type of machines for the automatic preparation of intravenous medication, such as, for example, the machine disclosed in PCT Patent Application WO 2012/172418 or in the Spanish Patent Application No. 201430745. Said machine tip allows, through the actuation of at least one actuator (such as a robotic arm), the preparation of specific medication resulting from the mixing of different base components. for intravenous administration, such as, for example, one type of drug and one type of solvent, in others. In this type of machines, the general procedure of automatic filling of infusor or cassette type tanks comprises steps that have not been illustrated in the present description.

    An example of embodiment of solvent filling by a peristaltic pump and of filling a drug using an actuator is described below.
    Proceed according to the following steps, which are illustrated in Figures 3 to 6.
    Stage a): Manual solvent dosing by peristaltic pump (not shown)
    In this first stage, filling of the infuser -1-with a solvent is carried out by means of a peristaltic pump connected on one side to a base solvent bag and on the other side it has a tube with a ~ Luer type connector LockM to connect a -1-infuser or a vial using a disposable punch.
    For said filling procedure, a solvent dosage set is used, this is a silicone tube that connects with the base solvent bag at one end, passes through the peristaltic pump and leaves a free Luer Lock end for medication container connection (infuser -1-). Said silicone tube comprises a double channel in the central part designed for connection to double channel peristaltic pumps, thus offering greater accuracy in dosages. Also, in this case a punch has been added at one of the ends of said silicone tube to pierce the solvent bag of
    20 base and a "Luer Lock" connector on the other end to connect the medication containers (infuser -1-with Luer Lock or disposable punch for solvent dosing in drug vials).
    Said step a) comprises the following sub-stages carried out manually by the operator in interaction with the automatic medication preparation machine:
    one. Purging of the peristaltic pump for the elimination of possible residues therein;
    2. Weighing of the -1-empty fuser on a scale attached to the machine;
    30 3. Connection of the "Luer LockM" connector of the infusion inlet port -1-to the "Luer LockM of the dosing set connected to the peristaltic pump for filling the infuser -1-with physiological serum as solvent;
    4. Disconnection of the infuser -1-from the dosing set at the "Luer Lock" end;
    5. Placement of the plug -2- "Luer Lock" with membrane or also called the additive point, by twisting it by hand into the infuser inlet port -1-;
    P201 431570
    6. Weighing the infuser -1-on a scale attached to the machine and placing a label for the pre-identification of the final product;
    7. Calculation by gravimetry of the volume of solvent dose introduced in the infuser -1-;
    5 8. Placing the infuser -1-on a container holder of the machine by means of a clamp that holds the infuser -1-by the plug -2- "Luer Lock" or additive point;
    9. Insertion of the clamp into the container holder of the machine, carefully arranging the infuser administration tubes -1-in the upper part so as not to
    10 interfere with actuator movements; said infuser -1-is arranged in the container holder of the machine so that the plug -2- "Luer Lock" or additive point is arranged inferiorly with respect to the rest of the infuser body
    -one-.
    10. Loading of the rest of the materials necessary for the preparation of the medication 15 -3-syringe with needle, medication vials);
    11. Closing the machine window for automatic medication preparation;
    Stage b) Automatic dosage of the drug in the infuser -1
    20 12. Removing the cap arranged on the needle -32-;
    13. Optionally, a cap absence detection method can be carried out by means of a machine cap absence detection module;
    14. Optionally, the weighing of the empty syringe -3 can be carried out to tare the balance;
    fifteen. Automatic presentation of the vial with the desired drug -7 for mixing in the extraction position;
    16. Extraction of the drug -7-from the vial by actuating the piston -30-of the
    syringe -3- by an actuator that clamps the syringe body 30 -3- with a clamp;
    17. Weighing the syringe -3-lIena to verify that the dose of drug -7-extracted is correct;
    18. In this sub-stage, as can be seen in Figure 3, the needle -32-,
    by actuating the robotic arm that holds the syringe -3-, 35 is positioned so as to puncture the membrane disposed on the upper surface -22-of the cap -2

    "Luer LockH Or additive point, the latter arranged at the input port -10 of the fuser -1-;
    19. Subsequently, the dose of drug -7-is injected directly into the infuser -1-by actuation of the plunger -30-of the syringe -3-by the actuator that clamps the syringe body by means of a clamp - 3-. As can be seen in Figure 5, as the drug -7- is introduced directly into the balloon -13-of the infuser -7-, said balloon -13- swells by storing said drug -7 -inside;
    twenty. Once the entire drug -7-has been emptied inside the infuser -1-, the needle -32-is removed from the cap -2- "Luer Lock ~ or point of additivation. At this moment, as can be seen in figure 6, the needle -32- is optionally arranged, by actuator actuation, inside -23-of the cylindrical duct -21- of said plug -2- ~ Luer Lock ~ and by a recoil of the piston -30 from the syringe -3- the possible possible volume -8-of remaining drug dose is extracted inside -23-of the cylindrical duct -21-of said cap -2- ~ Luer
    Lock ~;
    21. Optionally, in a final sub-stage, the weighing of the syringe -3- and calculation of the dead volume of the syringe -3- can be carried out by gravimetry.
    Said eventual volume -8-, called dead uvolumen ", does not get into the balloon -13-of the infuser -1-, and therefore will not be administered subsequently to the patient. However, the sub-stage 20 allows to know exactly the volume exact dose introduced inside the infuser -1-which will then be used directly to administer to the patient the medication prepared in said infuser -1-.
    Sub-caps 12 to 21 (some of them optional) can be repeated several times depending on the number of different drugs needed for the desired medication for the patient without the need to carry out connections and disconnections manually between a syringe (without needle and with connector uLuer Lock ~) and the input port -10-of the infuser -1-. Finally, once the desired mixture has been made, a series of additional sub-stages can optionally be carried out:
    22 Positioning the cap on the needle -32-;
    2. 3. A detection process is carried out that the cap is well placed and the syringe -3-is thrown into a garbage disposed in the machine;
    24. Automatic storage of the preparation and initialization data of the engines is carried out;
    25. The infuser -1-is removed from the container holder of the machine by removing the clamp from the container holder;

    5 26. A reading of the infuser pre-identification tag -1 is carried out to verify that the correct product has been unloaded;
    27. Weighing is carried out to verify that the dose of drug introduced in the infuser -1 is correct;
    28. Finally, an administration label is printed and pasted on the infuser -1-.
    Alternatively, said infusion method -1-can be performed both for the filling of drugs extracted from vials and of solvents extracted from bags, such as for example physiological serum disposed in a base bag. Therefore, alternatively, the preamble of step a) as well as steps 2 to 4 and
    15 that the filling of the solvent is carried out automatically, just like that of the drug.
    The following steps are followed for automatic solvent and drug filling:B1. Preparation of infuser -1- (as explained in points 5 and 6 above)indicated);
    20 B2. Infuser load -1- (as explained in points 8 to 11 above); B3 Preparation of syringe -3- (as explained in points 12 to 14 above); B4 Solvent extraction with the syringe -3- of an infusion bag placed in another position of the same compartment in which the infuser -1- is located.
    25 B5. Weighing syringe -3-with solvent. B6 Injection of the solvent in the infuser -1-. B7 Automatic dosage of the drug (as explained in points 14 to 28 above).
    30 In the case of using a cassette of type ~ cassette ~ for the filling of a mixture of drugs and solvent, the complete preparation in automatic can be advantageous although it requires the occupation of a container position inside the automatic preparation machine to position the base solvent bag. The order of filling of the drug and the solvent can be programmed interchangeably, existing in some
    35 preference centers for solvent filling at the end, to leave the administration route of the "cassette" filled with clean solvent.
    P201 431570
    The invention has been described with reference to a preferred version thereof, by way of example only. As will be understood, any person skilled in the art, having the knowledge that emerges from the present description, drawings and claims, may introduce modifications in the object of the invention which, if included within the broader interpretation of the claims , will be within the scope of protection of the invention.
    权利要求:
    Claims (7)
    [1]
    1. Method for automatic filling of containers for administration medicationintravenously in a machine for the automatic preparation of intravenous medication,5 said containers of the type comprising at least one input connector offluid closed by a plug comprising an internal through passage, saidmachine of the type comprising at least one driven nozzle means with punchby at least one actuator means also arranged in said machine, characterizedbecause said punch carries out a puncture of one of the ends of said plug,
    10 allowing direct injection of said component into said container.
    [2]
    2. A method according to claim 1, characterized in that after direct injection of said component into said container, the punch retracts into said duct of said cap by removing a volume of said base component
    15 remaining inside said duct.
    [3]
    3. Method according to claim 1, characterized in that the base component consists of a type of intravenous medication.
    Method according to claim 1, characterized in that the base component consists of a type of solvent.
    [5]
    Method according to claim 1, characterized in that said container comprises at least one elastomeric inflatable balloon connected to said fluid inlet connector and
    25 also comprises at least one outlet port connected internally to said inflatable balloon and externally connected to a tube for intravenous administration by infusion to the patient.
    [6]
    Method according to claim 1, characterized in that said container comprises at least one bag connected to a single fluid inlet and outlet connector.
    [7]
    Method according to any one of the preceding claims, characterized in that the injector means consist of a syringe with a plunger.
    Method according to claim 1, characterized in that the injector means consist of a bag comprising a base component, said bag being connected to a

    peristaltic pump that allows said component to be pumped through a silicone tube connected to said pump whose distal end is topped by a punch.
    [9]
    Method according to any one of the preceding claims, characterized in that the fluid inlet and / or outlet connectors and the closure plug are of the "Luer Lock ~" type.
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    同族专利:
    公开号 | 公开日
    PL3011985T3|2018-02-28|
    ES2549462B1|2016-02-10|
    ES2549462A8|2015-11-25|
    ES2657418T3|2018-03-05|
    EP3011985B1|2017-11-15|
    US10080835B2|2018-09-25|
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    US20180071453A9|2018-03-15|
    US20160114097A1|2016-04-28|
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    申请号 | 申请日 | 专利标题
    ES201431570A|ES2549462B1|2014-10-24|2014-10-24|Method for automatic filling of containers for intravenous administration medication in a machine for automatic preparation of intravenous medication|ES201431570A| ES2549462B1|2014-10-24|2014-10-24|Method for automatic filling of containers for intravenous administration medication in a machine for automatic preparation of intravenous medication|
    ES15382503.9T| ES2657418T3|2014-10-24|2015-10-14|Method for automatic filling of medication containers for intravenous administration in a machine for automatic preparation of intravenous medication|
    EP15382503.9A| EP3011985B1|2014-10-24|2015-10-14|Method for the automatic filling of containers for medication for intravenous administration in a machine for the automatic preparation of intravenous medication|
    PL15382503T| PL3011985T3|2014-10-24|2015-10-14|Method for the automatic filling of containers for medication for intravenous administration in a machine for the automatic preparation of intravenous medication|
    US14/920,690| US10080835B2|2014-10-24|2015-10-22|Method for the automatic filling of containers for medication for intravenous administration in a machine for the automatic preparation of intravenous medication|
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