• 专利附录
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  • 类似技术
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    • 专利摘要:
    Compounds and compositions comprising carbon nanotubes and compounds of formula (I) and their use as contrast agents. Compounds comprising carbon nanotubes and paramagnetic gadolinium chelates (III), derivatives of 1,4,7,10-tetraaza-1,4,7,10-cyclododecanotetraacetic acid (dota). These compounds are useful as contrast agents for nuclear magnetic resonance, a technique used to obtain images for clinical diagnosis and to provide alternative anisotropic contrast agents to those commonly used. The present invention relates to compounds comprising carbon nanotubes and compounds of formula (I), where the presence of a pyrene ring is indispensable for the formation of adducts through bonds π - π with carbon nanotubes, mono or multilayer and of length between 150 and 300 nm. R is selected, inter alia, by aliphatic amides, diamino derivatives, polyethylene glycol, alkyl squarate, and polyethylene glycol derivatives linked to dota monoamide. Their pharmaceutical compositions are used as contrast agents in anisotropic magnetic resonance imaging. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2541787A1
    申请号:ES201400058
    申请日:2014-01-23
    公开日:2015-07-24
    发明作者:Paloma Ballesteros García；Viviana NEGRI；Daniel CALLE HERNÁNDEZ
    申请人:Consejo Superior de Investigaciones Cientificas CSIC；Universidad Nacional de Educacion a Distancia UNED；Universidad Autonoma de Madrid；
    IPC主号:
    专利说明:

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    权利要求:
    Claims (1)
    [1]
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    类似技术:
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    同族专利:
    公开号 | 公开日
    ES2541787B1|2016-05-03|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    WO2006051142A1|2004-11-08|2006-05-18|Universidad Nacional De Educación A Distancia |1-pyrazolylethyl-1,4,7,10-tetraazacyclododecane-4,7,10-triacetic acids and application of the gadolinium complexes thereof in clinical diagnosis|
    US20130231475A1|2010-09-30|2013-09-05|Kyungpook National University Industry-Academic Cooperation Foundation|Mri contrast agent having gadolinium complex|
    US20130079503A1|2011-09-08|2013-03-28|Research & Business Foundation Sungkyunkwan University|Go-gd-dtpa complex, preparation method thereof, and mri contrast agent comprising the same|WO2019160419A1|2018-02-16|2019-08-22|Universiteit Leiden|Tripodal squaramide-based monomers|
    NL2020453B1|2018-02-19|2019-08-27|Univ Leiden|Tripodal squaramide-based monomers|
    法律状态:
    2016-05-03| FG2A| Definitive protection|Ref document number: 2541787 Country of ref document: ES Kind code of ref document: B1 Effective date: 20160503 |
    2016-08-01| PC2A| Transfer of patent|Owner name: UNIVERSIDAD NACIONAL DE EDUCACION A DISTANCIA Effective date: 20160726 |
    优先权:
    申请号 | 申请日 | 专利标题
    ES201400058A|ES2541787B1|2014-01-23|2014-01-23|Compounds and compositions comprising carbon nanotubes and compounds of formulaand their use as contrast agents|ES201400058A| ES2541787B1|2014-01-23|2014-01-23|Compounds and compositions comprising carbon nanotubes and compounds of formulaand their use as contrast agents|
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