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    • 专利摘要:
    the antimicrobial foaming composition of the present invention comprises a cationic active ingredient, a cationic compatible surfactant, a foam enhancer, a foam structure enhancing agent, dermal adjuvants and a carrier. the present antimicrobial compositions are free of triclosan (i.e., 2,4,4'-trichloro-2'hydroxy-diphenyl ether) antimicrobial agents and lower alcohols. they are also free of anionic surfactants. the foaming compositions have rapid acid activity, provide a stable and abundant foam, and exhibit improved tissue (e.g., skin) compatibility.
    公开号:BR112017002131B1
    申请号:R112017002131-5
    申请日:2015-07-30
    公开日:2021-07-27
    发明作者:Hilina Emiru；Cheryl A. Littau；Joseph R. Wegner；Daniel E. Pedersen；Mai Le；Amanda L. Wessinger
    申请人:Ecolab Usa Inc；
    IPC主号:
    专利说明:

    FIELD OF THE INVENTION
    [001] The present invention relates to antimicrobial compositions that result in a product that has superior aesthetic attributes, broad-spectrum antimicrobial efficacy and is also gentle on the skin. More particularly, the present invention relates to antimicrobial compositions that exhibit the antimicrobial effectiveness of cationic active ingredients, a cationic compatible surfactant, a foam enhancing agent, a foam structure enhancing agent and skin conditioning agent for reduced tissue irritation cutaneous of mammals. The composition is essentially free of aromatic biocides such as triclosan, anionic surfactants and C1 to C4 alcohols. FUNDAMENTALS OF THE INVENTION
    [002] Antimicrobial compositions for personal care are known in the art. Antimicrobial cleansing compositions are especially useful, as they are typically used to clean the skin and kill bacteria and other microorganisms present on the skin, especially on the user's hands, arms, and face.
    [003] Antimicrobial compositions are used, for example, in the healthcare industry; long-term care, hospitality and medical/exercise facilities; food service industry, meat processing industry, and in the private sector by individual consumers. The use of antimicrobial compositions is recognized as an important factor in controlling populations of bacteria and other microorganisms on the skin to reduce the potential spread of pathologies, particularly in care and food service environments. However, it is important that antimicrobial compositions provide a substantial and broad spectrum reduction in populations of microorganisms quickly and without problems associated with toxicity or skin irritation.
    [004] In particular, antimicrobial cleaning compositions typically contain an active antimicrobial agent, an anionic surfactant for cleaning and foaming, skin conditioning agents for cosmetic purposes, dyes, perfumes, and thickening agents such as clays, polymers , cellulosic derivatives, or colloids, for aesthetic purposes, all in an aqueous carrier.
    [005] Several different classes of antimicrobial agents have been used in antimicrobial cleaning compositions. They include active ingredients selected from the following classes: phenolic compounds, carbanalide compounds, lower alcohols and carboxylic acids. Each of these classes has its own unique advantages and challenges. Examples of specific antimicrobial agents include PCMX (para-chloromethoxylenol), triclosan, triclocarban, benzyl alcohol, quaternary ammonium compounds (QAC), iodine and iodine complexes and biguanides (eg, chlorhexidine digluconate). At this time, triclosan is the dominant antimicrobial active ingredient in the US dermal antiseptic cleaning solutions market.
    [006] Even though there is a growing consumer demand for products that have an activity against both bacteria and other microorganisms, there is an even greater demand to meet consumer expectations regarding their level of concern with certain biocides, such as triclocarbane and triclosan.
    [007] Triclosan is not approved as an antimicrobial agent due to environmental persistence and health concerns due to the possible formation of intermediate and/or environmental by-products. Therefore, there is a need for an effective antimicrobial personal care composition that is substantially free of biocides, such as triclocarban and triclosan, but still provides adequate foam volume during washing and a foam structure that leads to dense foam, rigid and stable desired by consumers and also be gentle on the skin. The present invention is directed to such antimicrobial compositions.
    [008] The aforementioned disadvantages of current antimicrobial compositions are addressed by the embodiments of the present invention and will be understood by reading and studying the following descriptive report. The following summary is intended as an example and is not limiting. It is merely provided to assist the reader in understanding some aspects of the invention. SUMMARY OF THE INVENTION
    [009] According to the present invention, a composition is provided that has superior aesthetic attributes, broad-spectrum antimicrobial efficacy and is also gentle on the skin. The antimicrobial composition comprises a cationic active ingredient, a cationic compatible surfactant which may include nonionic, cationic or amphoteric surfactants; a foam enhancing agent, a foam structure enhancing agent, skin conditioning agents, which may include emollients, humectants, vitamins, antioxidants; and water. The present antimicrobial compositions are free of the antimicrobial agent triclosan (i.e., 2,4,4'-trichloro-2'hydroxy-diphenyl ether), anionic surfactants, and C1 to C4 alcohols and have rapid acid efficacy. The compositions also provide a stable foam, yet no rinsing is required, and may optionally contain ingredients to enhance skin compatibility and skin health.
    [010] Correspondingly, one aspect of the present invention is to provide an antimicrobial composition for reducing the microbial population in dermal tissue, the antimicrobial composition comprising: (a) about 0.01% by weight to about 15% by weight of one or more cationic actives; (b) about 0.1% by weight to about 25% by weight of one or more cationic compatible surfactants (c) 0.01% to about 15% of one or more foam enhancing agents ( d) 0.01% to about 15% of one or more foam structure enhancing agents (e) 0.01% to about 15% of one or more skin conditioning agents, and (f) water or other suitable diluent, wherein the composition is essentially free of triclosan, anionic surfactants, cocamide DEA, betaine-based surfactants, triclosan, p-chloro-m-xylenol, and iodine.
    [011] Another aspect of the present invention is to provide an antimicrobial composition for reducing the microbial population in dermal tissue that is stable and has a pH of from about 5.0 to about 8.0. The present composition also exhibits excellent aesthetic properties, such as adequate foam volume during washing and foam structure that leads to a dense, rigid and stable foam. The present composition optionally contains ingredients to enhance skin health and compatibility. Furthermore, the composition may exhibit a reduced potential for tissue irritability.
    [012] A further aspect of the present invention is to provide personal use products based on an antimicrobial composition of the present invention, for example, a skin cleansing solution, a surgical brush, an antiseptic hand gel, a disinfectant , an antiseptic wash solution, and the like.
    [013] A further aspect of the present invention is to provide a method to reduce populations of gram positive and/or gram negative bacteria in mammalian tissue, including human tissue, by placing the tissue, such as the dermis, in contact with a composition of the present invention for a time sufficient, such as about 10 seconds to 5 minutes, to reduce the level of bacteria to a desired level. In some modalities, the time may be less than 5 seconds. Antimicrobial efficacy is applicable to viral and fungal organisms as well as gram positive and gram negative bacteria.
    [014] Although several embodiments are disclosed, still other embodiments of the present invention will become apparent to those of skill in the art from the following detailed description, which shows and describes illustrative embodiments of the invention. Correspondingly, the detailed description is to be regarded as illustrative in nature and not restrictive. BRIEF DESCRIPTION OF THE DRAWINGS
    [015] Figure 1 is a graph showing the foam stiffness and strength results from examples 1-5, 8, 9, 11 and 12.
    [016] Figure 2 is a graph that shows the results of stiffness and strength of the foam from examples 13 to 15.
    [017]Figure 3 is a graph showing the panel test results of example 13 vs. example 14
    [018]Figure 4 is a graph that shows the panel test results of the 15 vs formulation example. commercially available foam hand soaps.
    [019] Figure 5 is a graph showing the pH range of the antimicrobial efficacy of Exemplifying Formulation 15 at an exposure time of 30 seconds. DETAILED DESCRIPTION OF PREFERRED MODALITIES
    [020]Except in the operating examples, or where otherwise indicated, all numbers expressing amounts of ingredients or reaction conditions used herein are to be understood to be modified in all instances by the term "about".
    [021] Depending on the use in question, percent by weight (% w), percent by weight, % by weight, and the like are synonyms that refer to the concentration of a substance as the weight of such substance divided by the total weight of the composition and multiplied by 100.
    [022] Depending on the use in question, the term "about" that modifies the amount of an ingredient in the compositions of the invention or employed in the methods of the invention refers to the variation in the numerical amount that can occur, for example, through a measurement typical and liquid handling procedures used to produce concentrates or solutions for real-world use; through an inadvertent error in these procedures; through differences in the manufacture, source, or purity of the ingredients used to make the compositions or carry out the methods; and the like. The term "about" also encompasses amounts and proportions that differ due to different equilibrium conditions for a composition resulting from a particular starting mixture. Whether or not modified by the term "about", the claims include equivalents to amounts.
    [023] Depending on the use in question, the term “cationic active” is defined as the ingredient that provides an acidic antimicrobial activity.
    [024] According to the use in question, the term "cationically compatible" means a component that does not induce an insoluble complex with the cationic active agent and/or does not substantially reduce the antimicrobial action of the cationic active agent.
    [025]As used, the term “skin conditioning agent” is defined as the ingredient or ingredients that improve or maintain skin health and/or a post-wash aesthetic feel.
    [026]The term "alkyl" refers to a straight or branched chain monovalent hydrocarbon radical having a specific number of carbon atoms. As the usage in question, "alkyl" refers to a straight or branched C6-C18 carbon chain.
    [027] The term "microbial" or "microbial population" refers to bacterial, fungal, yeast, or viral populations or combinations thereof or any mixture thereof in a laboratory or natural environment.
    [028]The term rapid acid efficacy refers to a kill >3 log within 60 seconds in the ASTM E 2315 in vitro time kill test.
    [029] The term "surfactant" or "surface active agent" refers to an organic chemical that when added to a liquid changes the properties of that liquid on a surface or interface.
    [030]“Cleaning” means performing or assisting in the removal of dirt, bleaching, microbial population reduction, rinsing, or a combination thereof.
    [031] Depending on the usage in question, the term “free from” refers to a composition completely devoid of the component or having a small proportion of the component that does not affect the effectiveness of the composition. The component can be present as an impurity or as a contaminant and must be less than 0.5% by weight. In another embodiment, the component proportion is less than 0.1% by weight, and in yet another embodiment, the component proportion is less than 0.01% by weight.
    [032] It should be noted that, as used in this specification and the accompanying claims, the singular forms "a", "an", "the" and "a" include plural referents except where the context clearly indicates in contrary. So, for example, a reference to a composition containing “a compound” includes a mixture of two or more compounds. It should also be noted that the term “or” is used generically in its sense that includes “and/or” except where the content clearly indicates otherwise.
    [033] The terms "assets" or "percentage of assets" or "percentage by weight of assets" or "concentration of assets" are used interchangeably herein and refer to the concentration of those ingredients involved in cleaning expressed as a percentage less inert ingredients such as water or salts. Note that the percentages reported in the examples section are total percentages of components as received from commercial vendors and in the tables, do not include inert ingredients such as water or salts.
    [034] As used, the term "substantially free from" refers to compositions completely lacking the component or having a small proportion of the component that does not affect the performance of the composition. The component may be present as a minor constituent and/or impurity or contaminant and must be less than 5% by weight. In another embodiment, the component proportion is less than 1% by weight, and in yet another embodiment the component proportion is less than 0.1% by weight.
    [035] Depending on the usage in question, the terms "triclosan-free" or "triclosan-free" refers to a composition, mixture, or ingredients that do not contain triclosan (2,4,4'-trichloro-2'hydroxy- diphenyl ether) or compounds containing or to which triclosan has not been added. Triclosan or triclosan-containing compounds must be present through contamination of a composition, mixture, or ingredients, the proportion of which must be less than 0.5% by weight. In another modality the proportion of triclosan is less than 0.1% by weight, and in yet another modality the proportion is less than 0.01% by weight.ANTIMICROBIAL COMPOSITIONS CONTAINING ACTIVE ACTIVE COMPOUNDS
    [036] The present invention relates to an antimicrobial composition that exhibits rapid acidic antimicrobial efficacy and excellent foaming attributes. The antimicrobial composition comprises a cationic active ingredient, a cationic compatible surfactant which may include nonionic, amphoteric or cationic surfactants, a foam enhancing agent, a foam structure enhancing agent, a skin conditioning agent and water. The present antimicrobial compositions are free of the antimicrobial agent triclosan (i.e., 2,4,4'-trichloro-2'hydroxy-diphenyl ether), anionic surfactants, and C1 to C4 alcohols, have rapid acid effectiveness and provide bulk foam suitable during washing and foam structure which leads to dense, rigid and stable foam and also contain ingredients to increase skin compatibility and skin health.
    [037] Correspondingly, one aspect of the present invention is to provide an antimicrobial composition for reducing the microbial population in dermal tissue, the antimicrobial composition comprising: (a) about 0.01% by weight to about 10% by weight of one or more cationic actives; (b) about 0.1%, by weight, to about 12.5%, by weight, of one or more cationic compatible surfactants; foam (d) 0.01% to about 20% of one or more foam structure enhancing agents (e) 0.01% to about 15% of one or more skin conditioning agents, and (f) water or other suitable diluent, wherein the composition is essentially free of triclosan, anionic surfactants, DEA cocamide, betaine-based surfactants, triclosan, p-chloro-m-xylenol, and iodide.
    [038] Another aspect of the present invention is to provide an antimicrobial composition for reducing the microbial population in dermal tissue that is stable and has a pH of from about 5.0 to about 8.0. The present composition also exhibits excellent aesthetic properties during the washing process, providing adequate foam volume and a foam structure that leads to a dense, rigid and stable foam and ingredients to enhance skin compatibility and skin health. Furthermore, the composition can exhibit reduced tissue irritation potential.
    [039] A further aspect of the present invention is to provide products for personal use based on an antimicrobial composition of the present invention, for example, a skin cleansing solution, a surgical brush, a hand sanitizer, a disinfectant, and similar.
    [040] A further aspect of the present invention is to provide a method to reduce populations of gram positive and/or gram negative bacteria in mammalian tissue, including human tissue, by placing the tissue, such as the dermis, in contact with a composition of the present invention for a time sufficient, such as about 10 seconds to 5 minutes, to reduce the level of bacteria to a desired level.
    [041] The following illustrate non-limiting embodiments of the present invention. CATIONIC ASSETS
    [042] One or more cationic actives are present in an antimicrobial composition to reduce the microbial population in the dermal tissue of a mammal of the present invention in a proportion from about 0.01% by weight to about 10% by weight , and preferably from about 0.05% by weight to about 5% by weight, and more preferably from about 0.1% by weight to about 4% by weight , of the composition.
    [043] The proportion of antimicrobial agent in the composition is related to the final use of the composition. The proportion of antimicrobial agent is sufficient in the compositions of the invention to achieve a microbial kill in a short contact time, for example, 15 to 30 seconds.
    [044] The cationic active ingredients consist of an antimicrobial agent useful in the present invention. Cationic active ingredients are substances based on cationic moieties with a nitrogen center with net positive change. Cationic active ingredients are preferably selected from the group consisting of cationic polymers, cationic surfactants, cationic monomers, cationic silicon compounds, cationic derivative protein hydrolysates and betaines with at least one cationic or cationically active group.
    [045]Suitable cationic active ingredients contain quaternary ammonium groups. Suitable cationic active ingredients especially include those of the general formula: N(+)R1R2R3R4X(-)
    [046]wherein R1, R2, R3 and R4 independently of each other represent alkyl groups, aliphatic groups, aromatic groups, alkoxy groups, polyoxyalkylene groups, alkylamido groups, hydroxyalkyl groups, aryl groups, H+ ions, each with from 1 to 22 carbon atoms, with the provision that at least one of the groups R1, R2, R3 and R4 has at least eight carbon atoms and where X(-) represents an anion, for example a halogen, acetate, phosphate, nitrate or alkyl sulfate, preferably a chloride. Aliphatic groups may also contain cross-linking groups or other groups, for example additional amino groups, in addition to carbon and hydrogen atoms.
    [047] Particular cationic active ingredients include, for example, but not limited to, alkyl dimethyl benzyl ammonium chloride (ADBAC, or benzalkonium chloride), alkyl dimethyl ethyl benzyl ammonium chloride, dialkyl dimethyl ammonium chloride, sodium chloride benzethonium, N,N-bis-(3-aminopropyl) dodecylamine, chlorhexidine gluconate, a chlorhexidine gluconate salt, PHMB (polyexamethylene biguanide), a biguanide salt, a substituted biguanide derivative, an organic salt of a compound containing quaternary ammonium or an inorganic salt of a compound containing quaternary ammonium or mixtures thereof.
    [048] According to an important feature of the present invention, a present antimicrobial composition is substantially free of triclosan. The phrase "substantially free" of triclosan is defined to mean that the composition contains from 0% to about 0.25%, by weight, in total triclosan. In particular, triclosan may be present in an antimicrobial composition in a total proportion of 0.25% or less either as a by-product or as a component of an ingredient in the composition, but triclosan is not intentionally introduced into the composition. CATIONIC COMPATIBLE SURFACE-ACTIVE COMPONENT
    [049] The present antimicrobial composition also contains one or more compatible cationic surfactants. These surfactants include non-ionic, amphoteric or cationic surfactants. One or more cationic compatible surfactants are present in a proportion of from about 0.1% by weight to about 12.5% by weight, preferably about 0.5% by weight to about 10 % by weight, and more preferably from about 1% by weight to about 7.5% by weight of the composition. In a particularly preferred embodiment, the surfactant component comprises less than 5% by weight of the composition.
    [050]The proportion of cationic compatible surfactant present in the composition is related to the proportion of cationic active in the composition, the identity of the cationic compatible surfactant, and the final use of the composition.
    [051] Suitable cationic compatible surfactants include compounds that function as primary cleaning and foaming ingredients, they may be (a) nonionic surfactants, (b) amphoteric surfactants, or (c) cationic surfactants, or mixtures thereof. The formulation is essentially free of anionic surfactants. NON-IONIC SURFACTANTS
    [052] Examples of nonionic surfactants include, but are not limited to, amine oxide surfactants, which may be: di(C1-C7) alkyl amine oxides whose alkyl group has about 10 to 20, and, of preferably 12 to 16 carbon atoms, and may be straight chain or branched, saturated or unsaturated. Examples of such compounds include lauryl dimethyl amine oxide, myristyl dimethyl amine oxide, and those whose alkyl group is a mixture of different amine oxides, dimethyl cocoamine oxides, dimethyl (hydrogenated tallow) amine oxides, and myristyl/palmitil oxides dimethyl amine; alkyl di(C 1 -C 7 hydroxy hydroxy amine oxides) whose alkyl group has about 8 to 20, and preferably 12 to 16 carbon atoms, and may be straight chain or branched, saturated or unsaturated. Examples of such compounds include (2-hydroxy ethyl) cocoamine oxide, bis(2-hydroxy ethyl) tallow amine oxide; and bis(2-hydroxy ethyl) stearyl amine oxide; alkylamidopropyl di(C1-C7) amine oxides whose alkyl group has about 8 to 20, and preferably 12 to 16 carbon atoms, and can be straight or branched chain, saturated or unsaturated. Examples of such compounds include cocoamidopropyl dimethyl amine oxide and amidopropyl dimethyl amine tallow oxide; and alkyl morpholine oxides whose alkyl group has about 10 to 20, and preferably 12 to 16 carbon atoms, and may be straight chain or branched, saturated or unsaturated. Particularly preferred alkyl amine oxides are those whose alkyl group has about 10 to 14, and preferably has 12 carbon atoms, which are preferably saturated. Lauryl dimethyl amine oxide is especially preferred.
    [053]Additional nonionic surfactants include alcoholic ethoxylates, fatty acid ethoxylates, alkyl phenol ethoxylate, monoalconaolamide ethoxylates, sorbitan esters and their ethoxylated derivatives, ethoxylated fats and oils, amine ethoxylates, ethylene oxide copolymers of propylene, glycol esters, glycerol and polyglycerol esters, sucrose ester mono and polysaccharide surfactants, such as alkyl polyglycosides.
    [054]The antimicrobial composition may contain a nonionic surfactant component that includes a detersive proportion of nonionic surfactant or a mixture of nonionic surfactants. Typically, a nonionic surfactant has a hydrophobic region, such as a long chain alkyl group or an alkylated aryl group, and a hydrophilic group comprising an ethoxy and/or other hydrophilic moieties. AMPHOTERIC SURFACE ACTIVE
    [055]The cationic compatible surfactant component may include a detersive proportion of amphoteric surfactant or a mixture of amphoteric surfactants. Exemplary useful amphoteric surfactants include those which can be represented by the following general formula.

    [056]wherein, R represents a C4 to C24 alkyl group, and preferably is a C10 to C16 alkyl group, R1 and R2 independently represent a C1 to C8 alkyl group, is preferably --CH2CH2—or --CH2CH2CH2--, and M can be any salt-forming anion that affords water solubility or water miscibility of the compound, for example, chloride, bromide, methosulfate, ethosulfate, lactate, saccharate, acetate, or phosphate. Such compounds are currently commercially available, such as those marketed in the Tomamine Amphoteric series of amphoteric surfactants, eg, Air Products Inc.
    [057] Additional amphoteric surfactants that can be used include, but are not limited to, imidiazolines and imidiazoline derivatives, betaine derivatives, amphoacetate derivatives, propionates and mixtures thereof.
    [058]Exemplary betaine surfactants include those that can be represented by the general formula:

    [059]wherein R1 is an alkyl group containing from 8 to 18 carbon atoms, or the amido radical which can be represented by the following general formula:

    [060]wherein R is an alkyl group having from 8 to 18 carbon atoms, a is an integer having a value from 1 to 4 inclusive, and R2 is a C1C4 alkylene group. Examples of such water-soluble betaine surfactants include dodecyl dimethyl betaine as well as cocoamidopropyl betaine.
    [061] One or more amphoacetates, such as sodium lauroamphoacetate, or dianphoacetates may also be used. Amphoacetates can be represented by the following general formula:

    [062]e, diaphoacetates can be represented by the following general formula:

    [063]wherein in both formulas, R represents an aliphatic group having from 8 to 18 carbon atoms, R1 represents an aliphatic group having from 1 to 5 carbon atoms, but preferably it is --CH2--, or --CH2CH2--, and M is a cation, such as sodium, potassium, ammonium, or substituted ammonium. Examples of such compounds include: sodium lauroamphoacetate, sodium cocoamphoacetate, disodium lauroamphoacetate, and disodium cocoamphoacetate. In a preferred embodiment, the composition is substantially free of sodium cocoamphoacetate and cocoamidoproyl hydroxysultaine which may reduce the antimicrobial activity of the cationic active compound.
    [064] In a preferred embodiment, the composition is also substantially free of betaine-based surfactants. CATIONIC SURFACANT
    [065]The surfactant component of the composition may also include a detersive proportion of cationic surfactants or a mixture of cationic surfactants. Cationic surfactants that can be used in the antimicrobial composition include, but are not limited to, quaternized sugar-derived surfactants, quaternized polysaccharides, quaternized alkyl polysaccharides, alkoxylated amines, alkoxylated ether amines, and mixtures thereof. The proportion of cationic compatible surfactant present in the composition is related to the proportion of cationic active in the composition, the identity of the cationic surfactant, and the final use of the composition.
    [066] The cationic compatible surfactant can be a quaternized sugar derived surfactant that is a quaternized alkyl polyglycoside or a polyquaternized alkyl polyglycoside, and the like.
    [067]Quaternary functionalized alkyl polyglycoside is a cationic surfactant naturally derived from alkyl polyglycosides and has a sugar backbone. Quaternary functionalized alkyl polyglycosides have the following representative formula:

    [068]wherein R1 is an alkyl group having from about 6 to about 22 carbon atoms, and R2 is CH3(CH2)n' where n' is an integer ranging from 0 to 21. Examples of polyglycoside components Suitable quaternary functionalized alkyl groups that can be used in the cleaning compositions in accordance with the present invention include those whose alkyl portion R1 contains primarily about 10 to 12 carbon atoms, the group R2 is CH3 and n is the degree of polymerization of 1 to 2. Additional examples of a suitable quaternary functionalized alkyl polyglycoside include, but are not limited to, the antimicrobial and antifungal quaternary functionalized alkyl polyglycosides described in US Patents 7,084,129 and US 7,507,399, the disclosures of which are incorporated herein. by way of reference. Examples of commercially suitable quaternary alkyl functionalized polyglycosides useful in cleaning compositions of the present invention include, but are not limited to: Suga ®Quat TM 1212 (primarily C12 quaternary alkyl functionalized polyglycoside), Suga ®Quat L 1210 (primarily alkyl polyglycoside) C12 functionalized quaternary), and Suga ®Quat S 1218 (primarily C12 functionalized alkyl polyglycoside) available from Colonial Chemical, Inc., headquartered in South Pittsburg, TN, USA.
    [069] A polyquaternary alkyl polyglycoside is naturally derived from alkyl polyglycosides and has a sugar backbone. Polyquatemary alkyl polyglycosides have the following representative formula:

    [070]wherein R is an alkyl group having from about 6 to about 22 carbon atoms and n is an integer ranging from 4 to 6. Examples of suitable polyquaternary functionalized alkyl polyglycosides that can be used in the compositions include those whose alkyl portion R contains from about 8 to about 12-carbon atoms. In a preferred embodiment, the quaternary functionalized alkyl polyglycoside primarily contains about 10 to 12 carbon atoms. Examples of commercially available polyquaternary alkyl functionalized polyglycosides useful in cleaning compositions of the present invention include, but are not limited to: Poly Suga ®Quat series of quaternary alkyl functionalized polyglycosides, available from Colonial Chemical, Inc., based in South Pittsburg. , TN, USA. FOAM ENHANCING AGENT
    [071] The compositions of the invention include one or more foam enhancing agents. They are present in the composition in a proportion from about 0.01% by weight to about 15% by weight, preferably from about 0.05% by weight to about 10% by weight. weight, and more preferably from about 1% by weight to about 5% by weight. Suitable foam enhancing agents include compounds that increase the volume of foam in a user's hands. Specifically, for a foam formulation to remain in the foam phase, bubbles in the foam must maintain their shape and volume without draining. When a drainage occurs, the liquid from the outer portion or lining of the bubbles drains through the foam due to the action of gravity and the bubbles cease to exist from top to bottom. As the foam volume decreases, the formulation balance begins to build up under the remaining foam as liquid as there are no more bubbles and liquid is all that is left.
    [072] Some examples of foam enhancing agents include caprylate sorbinate sesquicaprylate/glyceryl caprate, phospholipids, phospholipid derivatives, PEG dimethicone with methyl esters, PEG-7 glyceryl cocoate, and capric/caprylic monoglycerides.
    [073] The composition, in a preferred embodiment, includes glyceryl caprylate/caprate which the inventors have identified as a foam enhancing agent. The caprylate/glyceryl caprate foaming agent, which may be present as part of the foaming component, may be present in a proportion of from about 0.05% by weight to about 8% by weight of preferably, from about 0.1% to about 5%, by weight.
    [074]The foam enhancer component can also include a polymer. Polymers that function according to the invention comprise a hydrophobically modified cationic polymer obtainable from polymerization of the following structural units:
    [075] (i) a first structural unit derived from one or more cationic ethylenically unsaturated monomers;
    [076] (ii) a second structural unit derived from one or more water-soluble monomers. (i) First Structural Unit
    [077]The first structural unit is a water-soluble cationic ethylenically unsaturated monomer. The first structural unit can be a dialkyl diallyl ammonium with halides, hydrogen sulfate or methosulfate as counterions according to formula (I):

    [078]where:
    [079]R1 and R2are, independently of one another, hydrogen or C1-C4 alkyl;
    [080] R3 and R4 are, independently of one another, hydrogen, alkyl, hydroxyalkyl, carboxyl alkyl, carboxyamide alkyl or alkoxyalkyl groups having from 1 to 18 carbon atoms; and
    [081] Y— is the counterion selected from the group consisting of chloride, bromide, iodide or hydrogen sulfate or methosulfate.
    [082] In another embodiment, the first structural unit is a quaternary salt or acid of dialkyl amino alkyl (meth)acrylate. In a further embodiment, the first structural unit is an acid salt of a dialkyl amino alkyl (meth)acrylamide or a quaternary dialkyl amino alkyl (meth)acrylamide according to formula (II):

    [083]where:
    [084] R1 is H or C1-C4 alkyl;
    [085] R2 is H or methyl;
    [086] R3 is C1-C4 alkylene;
    [087] R4, R5 and R6 are independently H or C1-C30 alkyl;
    [088] X is -O- or -NH-; and
    [089] Y is Cl; Br; I; hydrogen sulfate or methosulfate.
    [090] In one embodiment of the present invention, it is preferred that, in the cationic monomer of formula (II), in which:
    [091] R1 and R2 are each H or
    [092] R1 is H and R2is CH3 or, preferably, also H.
    [093] Suitable examples of the first structural unit are diallyl dimethyl ammonium chloride (DADMAC), (3-acrylamidopropyl)-trimethylammonium chloride (APTAC), (3-methacryl-amidopropyl)-trimethylammonium chloride (MAPTAC), dimethylaminopropylacrylate methochloride, dimethylaminopropylmethacrylate methochloride. Additional suitable examples of the first structural unit are [2-(acryloyloxy)ethyl]trimethylammonium chloride, also referred to as dimethylaminoethyl acrylate (DMA3*MeCl), or trimethyl-[2-(2-methylprop-2-enoyloxy) chloride ethyl]azanium, also referred to as dimethylaminoethyl methacrylate methochloride (DMAEMA*MeCl). Preferably, the first structural unit is DADMAC.(ii) Second Structural Unit
    [094] The second structural unit is acylamide or methacrylamide
    [095]The entire percentage, by weight, for each of the structural units is calculated based on 100%, by weight, of all structural units derived from all monomers in the copolymer. A preferred copolymer is a DADMAC/(meth)acrylamide copolymer with a molecular weight of approximately 2,000,000, such as the Mackermium 007 line of copolymers available from Rhodia, Inc. FOAM STRUCTURE ENHANCER AGENT
    [096] Foam structure enhancing agents are agents that change the physical structure of the foam including foam stability, bubble size, density and stiffness, thus conferring sensory attributes during the washing process. Users can describe these sensory attributes as foaming, creaminess, cushioning, and/or slipping.
    [097] In a preferred embodiment, an innovative foam structure agent is disclosed as a linear, unsubstituted high molecular weight polyethylene glycol such as PEG 300 or greater, or PEG 1000 or greater. In a particularly preferred embodiment, PEG 8000 is the foam structure enhancing agent. One or more foam structure enhancing agents are present in a proportion of from about 0.01% by weight to about 20% by weight, preferably from about 0.05% by weight to about from 15% by weight, and more preferably from about 1% by weight to about 10% by weight.
    [098] Examples of other foam structure enhancing agents include an organic solvent, other than a short-chain alcohol, typically soluble in both water and oil. Examples of foam structure enhancing agents according to the present invention include: polyols such as glycerol (glycerin), propylene glycol, hexylene glycol, diethylene glycol, propylene glycol n-alkanols, ethylene glycol, other glycols, ethoxylated glyceride monooleate (with 8 to 10 ethylene oxide units); esters like isopropyl myristate/palmitate, myristyl alcohol, lauryl alcohol, lauryl lactate, amides like acetamide oleates like triolein. In a preferred embodiment, the foam stabilizer is hexylene glycol.
    [099] The constituents of the foam structure enhancing agents may also comprise at least one fatty alkanolamide, examples thereof include, but are not limited to: cocamide MEA, cocamide DEA, soy amide DEA, lauramide DEA, Oleamide MIPA, stearamide MEA, myristamide MEA, lauramide MEA, capramide DEA, ricinoleamide DEA, myristamide DEA, stearamide DEA, oleylamide DEA, tallow amide DEA, lauramide MIPA, amide MEA tallow, isostearamide DEA, isostearamide MEA, and mixtures thereof. Alkanol amides may also provide an auxiliary thickening benefit. A preferred alkanol amide is diisopropanolamide, such as the Cola® liquid non-DEA amides available from Colonial Chemical which include cocamide DIPA (diisopropanolamide), soy amide DIPA, lauramide DIPA, or myristamide DIPA. In a preferred embodiment, the composition is substantially free of DEA and/or MEA, as in cocamide DEA. In yet another preferred embodiment, the composition includes diisopropanolamide as a part of the foam structure enhancing component. Diisopropanolamide may be present throughout the composition in a proportion of from about 0.01% by weight to about 8% by weight to about 0.05% by weight to about 5% by weight , and more preferably from about 0.1% by weight to about 3% by weight.
    [0100]Additional foam structure enhancing agents may include agents that modify slip during the handwashing process helping the foam structure enhancing agents to flow more easily and more smoothly into a user's hands. Examples of such agents may include; caprylyl glycol, ethylhexyl glycerin and phenoxyethanol. In a preferred embodiment, the foam structure enhancing agent is phenoxyethanol. Phenoxythanil is generally recognized as a preservative; however, it has surprisingly been found to act as an excellent foam structure enhancing agent. The slip modifying agent is present in the composition in a proportion from about 0.05% by weight to about 10% by weight, preferably from about 0.1% by weight to about 7 % by weight. DERMIC ADJUVANTS / SKIN CONDITIONING AGENTS
    [0101] The composition may contain from about 0.01% by weight to about 15% by weight of dermal adjuvants, preferably from about 0.05% by weight to about 10% by weight, and more preferably from about 1% by weight to about 5% by weight. Dermal adjuvants/skin conditioning agents generally include any substance that improves or maintains the health of the epidermis. Some examples include, but are not limited to, emollients, humectants, vitamins, antioxidants, skin nutrients, skin moisturizers and conditioners.
    The composition may include emollients including, without limitation, dicaprilyl carbonate, dibutyl adipate, hexyl laurate, dicaprilyl ether, propyl heptyl caprylate. Also included are natural and synthetic ethoxylated oils. Examples include C12-15 alkyl benzoate, capric triglyceride, caprylic triglyceride, isopropyl moristrate, isopropyl palmitate, octyldodecanol, decyl oleate, cocoglycerides, ethyl hexyl stearate, ceteraryl isononanoate, cetyl cetyl hexanoate, ethyl hexanoate dimethicone, ethyl hexyl palmitate, PPG-11 stearyl ether, PPG-15 stearyl ether and PPG-14 butyl ether.
    [0103]These materials may also include derivatives of water-soluble oils and waxes, ethoxylated fats and oils, lanolin ethoxylate; examples include mono-, di-, and tri-glycerides and butters and hydrogenated versions of seed and oilseed oils including, without limitation; palm oil, coconut oil, vegetable oil, avocado oil, canola oil, corn oil, soybean oil, sunflower oil, safflower oil, meadowfoam seed oil, cranberry seed oil, seed oil of watermelon, olive oil, cranberry, macadamia oil, argan oil, pomegranate oil, Moroccan argan oil, blueberry oil, raspberry oil, walnut oil, pecan oil, peanut oil, peanut oil, myrica, mango seed oil, marula oil, castor oil, shea butter, jojoba oil, hydrolyzed jojoba oil, carnauba butter, carnauba wax, castor stearyl isostearate heptanoate, cetyl ricinoleate, frucate of oleyl, sucrose monostearate, sucrose distearate, sucrose tristearate, sucrose tetrastearate, cetyl alcohol, lanolin, lanolin ethoxylate, low molecular weight polyethylene waxes, low molecular weight polypropylene waxes, PEG-glyceryl cocoate 30, PEG-80 glyceryl cocoate, is PEG-30 Glyceryl Erate, PEG-8 Ricinoleate, PEG-8 Raspberry, Linear Versions (also known as bis) and Hydroxyl Termination and Methyl Ether Termination Inclusion Pendants; PEG-3 to PEG-32 Dimethicone (including, without limitation: PEG-3 Dimethicone, PEG-8 Dimethicone, PEG-9 Dimethicone, PEG-10 Dimethicone, PEG-11 Dimethicone Methyl Ether, PEG Dimethicone -12, PEG-14 Dimethicone, PEG-17 Dimethicone, PEG-32 Dimethicone), Bis-PEG/PPG-20/20 Dimethicone, PEG/PPG 20/23 Dimethicone, Butyl Ether PEG/PPG Dimethicone 20/22, PEG/PPG Dimethicone 23/6, PEG/PPG Dimethicone 20/15.
    [0104]Alkyl modified dimethicone (stearoxy dimethicone, behenoxy dimethicone, cetyl dimethicone, certeryl methicone, C30-45 alkyl cetearyl dimethicone, C30-45 alkyl dimethicone, caprylyl methicone, PEG-8 dimethicone, dimeric dimeric acid copolymer Bis-PEG-10 dimethicone/dimeric dilinoleate copolymer, stearoxy methicone/dimethicone copolymer, diphenyl dimethicone, lauryl polyglycerol-3 polydimethylsiloxy ethyl dimethicone, lauryl polydimethylsiloxy ethyl dimethicone), dimethicone fluid (>20cst silicone polymers), quaternized ammonium, amino silicones, silicone quaternium-18, amodimethicone, phenyltrimethicone, amino silicone polyethers, polyglycerol-3 disiloxane dimethicone, polyglycerol-3 polydimethylsiloxy ethyl dimethicone, and PEG-9 polydimethylsiloxy ethyl dimethicone.
    [0105] The composition may include one or more skin conditioners, such as vitamins, humectants, an occlusive agent, or other moisturizing material to provide skin hydration, skin softening, skin barrier maintenance, anti-irritation, or others skin health benefits. Some non-limiting examples of additional skin conditioners include cationic and non-ionic guar and derivatives thereof, alkyl benzoate, myristyl myristate, cetyl myristate, gelatin, lactic acid, glyceryl dioleate, methyl laurate, PPG-9 laurate , lauryl lacylate, allantoin, octyl palmitate, lanolin, propylene glycol, butylene glycol, ethylene glycol, caprylyl glycol, monobutyl ether, glycerin, fatty acids, proline, natural oils such as almond oil, mineral, canola, sesame, soybean, pyrrolidine, wheat germ, hydrolyzed wheat protein, hydrolyzed cereal protein, hydrolyzed collagen, corn, peanut and olive, isopropyl myristate, myristyl alcohol, aloe vera, seaweed extract, cocamidopropyl chloride PG demon phosphate, gluconic acid , hydrolyzed silk protein, 1,3-propane-diol, vitamin E, nicatinamide, stearyl alcohol, isopropyl palmitate, sorbitol, amino acid complexes, panthenol, cocoamidopropyl PG demon chloride io, quaternized hydrolyzed protein such as collagen, cereal, wheat, etc..., inositol, fructose, sucrose, hydrolyzed vegetable proteins, kelp extract, polyethylene glycol, ammonium lactate, sodium hyaluronate and cyclic peptides.
    [0106] Some non-limiting examples of humectants include hydroxyethyl urea, agarose, urea, fructose, glucose, glutamic acid, glycerin, honey, lactose, maltose, polyethylene glycol, sorbitol and mixtures thereof.
    [0107] Some non-limiting examples of occlusive agents include ethoxylated petrolatum, ethoxylated version of shea butter, avocado oil, lemon balm oil, cod liver oil, mineral oil, trimyristin, stearyl stearate, synthetic wax, or mixtures thereof. Some non-limiting examples of other moisturizers include ethyl hexylglycerin, cholesterol, cystine, hyaluronic acid, keratin, lecithin, egg white, glycine, PPG-12, polyquaternium polymers such as polyquaternium-11, behetrimonium bandstand, dihydroxy propyl PEG -5 linolemonium, glycerol oleate, PEG-7 glyceryl cocoate, cocoglucoside, PEG-200 hydrogenated glyceryl palmate, panthenol, retinol, salicylic acid, vegetable oil, methyl glucet-10, methyl glucet-20, ethoxylated derivatives of skin conditioners such as glyceret-26 and ethoxylated shea butter, and mixtures thereof. Finally, some non-limiting examples of anti-irritants include bisabolol and panthenol.
    [0108] The skin conditioner can include an antioxidant for improved skin condition through the removal of free radicals, and improved product stability. Some non-limiting examples of antioxidants include retinol and retinol derivatives, ascorbic acid and ascorbic acid derivatives, BHA, BHT, beta carotene, cysteine, erythorbic acid, hydroquinone, tocopherol and tocopherol derivatives, and the like. CONDOMS
    [0109] The composition may optionally include a preservative. In general, preservatives fall into specific classes that include phenolics, halogen compounds, quaternary ammonium compounds, metal derivatives, amines, alkanolamines, nitro derivatives, biguanides, analides, organosulfur and sulfur-nitrogen compounds, alkyl parabens, and miscellaneous compounds. Some non-limiting examples of phenolic preservatives include pentachlorophenol, orthophenylphenol, chloroxylenol, p-chloro-m-cresol, p-chlorophenol, chlorothymol, m-cresol, o-cresol, p-cresol, isopropyl cresols, mixed cresols, phenoxyethanol, phenoxyethylparaben , phenoxyisopropanol, phenyl paraben, resorcinol, and derivatives thereof. Some non-limiting examples of halogen compounds include sodium trichloroisocyanurate, sodium dichloroisocyanurate, iodine-poly(vinylpyrolidin-onen) complexes, and bromine compounds such as 2-bromo-2-nitropropane-1,3-diol, and derivatives of the same. Some non-limiting examples of quaternary ammonium compounds include benzalkonium chloride, benzethonium chloride, behetrimonium chloride, cetrimonium chloride, and derivatives thereof. Some non-limiting examples of amines and nitro-containing compounds include hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine, dithiocarbamates, such as sodium dimethyldithiocarbamate, and derivatives thereof. Some non-limiting examples of biguanides include polyaminopropyl biguanide and chlorhexidine gluconate. Some non-limiting examples of alkyl parabens include methyl, ethyl, propyl and butyl parabens.
    [0110] The preservative is preferably present in the composition in a proportion of from about 0.01% by weight to about 5% by weight to about 0.05% by weight to about 3%, by weight, and from about 0.1% by weight to about 2% by weight. CARRIER
    [0111] The carrier of the present antimicrobial composition comprises water, propylene glycol, glycerols, alcohols or mixtures thereof. It should be appreciated that the water can be supplied as deionized water or as softened water. The water supplied as part of the composition can be relatively free from hardness. It is expected that water can be deionized to remove a portion of the dissolved solids. That is, the concentrate can be formulated with water that includes dissolved solids, and it can be formulated with water that can be characterized as hard water. The carrier present in the composition may be present in a proportion of from about 30% by weight to about 99% by weight, preferably from about 55% by weight to about 97% by weight, and more preferably from about 68% by weight to about 95% by weight. OPTIONAL PH ADJUSTMENT AGENT
    [0112] The antimicrobial composition of the present invention does not depend on a low pH or a high pH to provide a rapid reduction in microbial populations. The composition for the present invention has a pH of from about 5.0 to about 8.0. Within this pH range, the present composition effectively reduces microbial populations, and is acceptable to consumers, i.e., it provides adequate foam volume during washing, generates a stable, dense and rigid foam, and is soft to the skin and stable on phase.
    [0113] In some instances, a pH adjusting compound may be needed in a sufficient proportion to provide a desired composition pH. To achieve the full advantage of the present invention, the pH adjusting compound is present in a proportion of from about 0.05% to about 3.5% by weight.
    [0114]Examples of basic pH adjusting compounds include, but are not limited to, ammonia; mono-, di-, and trialkyl amines; mono-, di-, and trialkanolamines; alkali metal and alkaline earth metal hydroxides; alkali metal phosphates; alkaline sulfates; alkali metal carbonates; and mixtures thereof. However, the identity of the basic pH adjuster is not limited, and any basic pH adjuster compound known in the art can be used. Specific non-limiting examples of basic pH adjusting compounds are ammonia; sodium, potassium, and lithium hydroxide; sodium and potassium phosphates, including hydrogen and dihydrogen phosphates; sodium and potassium carbonate and bicarbonate; sodium and potassium sulfate and bisuphate; monoethanolamine; trimethylamine; isopropanolamine; diethanolamine; and triethanolamine.
    [0115]The identity of an acidic pH adjusting compound is not limited and any acidic pH adjusting compound known in the art, alone or in combination, can be used. Examples of specific acidic pH adjusting compounds are mineral acids and polycarboxylic acids. Non-limiting examples of mineral acids are hydrochloric acid, nitric acid, phosphoric acid, and sulfuric acid. Non-limiting examples of polycarboxylic acids are citric acid, glycolic acid and lactic acid. ADDITIONAL FUNCTIONAL MATERIALS
    [0116]The antimicrobial composition may include additional components or agents, such as additional functional materials. As such, in some embodiments, the antimicrobial composition comprises a cationic active ingredient, a cationic compatible surfactant, a foam enhancing agent, a foam structure enhancing agent, a skin and water conditioning agent, or even the total weight of the antimicrobial composition, for example, in embodiments having little or no additional functional material provided herein. Functional materials provide desired properties and functionality to the antimicrobial composition. For the purpose of this application, the term "functional materials" includes a material which when dispersed or dissolved in a use solution/or concentrate, such as an aqueous solution, provides a beneficial property in a particular use. The antimicrobial composition comprises a cationic active ingredient, a cationic compatible surfactant, a foam enhancing agent, a foam structure enhancing agent, a skin conditioning agent and water. It may optionally contain chelators, pH adjusting compounds, antioxidants, fragrances, dyes, other disinfectants, sanitizers, thickening or gelling agents, or mixtures thereof. Some particular examples of functional materials will be discussed in greater detail below, but it should be understood by those skilled in the art and by third parties that the particular materials discussed are given by way of example only, and that a wide variety of other functional materials may be used. For example, many of the functional materials discussed below refer to materials used in disinfectant and/or cleaning applications, but it should be understood that other modalities may include functional materials for use in other applications. CHELATING AGENT
    [0117]In general, the composition is a concentrate or a ready-to-use composition that may optionally include a chelating agent. In general, a chelating agent is a molecule capable of coordinating (ie, binding) metal ions commonly found in water sources to prevent metal ions from interfering with the action of other ingredients. Examples of chelating agents include phosphonic acid and phosphonates, phosphates, aminocarboxylates and their derivatives, pyrophosphates, ethylenediamine and ethylenetriamine derivatives, hydroxy acids, and mono-, di-, and tri-carboxylates and their corresponding acids. In certain embodiments, the composition is phosphate free. Preferred chelating agents form calcium chelating agent complexes with a stability constant (expressed in log form) of about 5.5 or greater. The calcium chelating agent stability constant (K) is a measure of the stability of a calcium chelating agent (CaL) complex formed by the reaction of a calcium ion (Ca) with a chelating agent (L) in an aqueous solution .

    [0118] The stability constant is expressed as:

    [0119]where:
    [0120]K = stability constant for the calcium chelating agent complex
    [0121][CaL] = concentration (mol/L) of the calcium chelating agent complex
    [0122][Ca] = concentration (mol/L) of calcium ions
    [0123][L] = concentration (mol/L) of the chelating agent
    [0124] Preferred chelating agents are selected from the group comprising ethylenediamine tetraacetic acid (EDTA); diethylenetriamine pentaacetic acid (DTPA); methylglycine-N,N-diacetic acid (MGDA); glutamic acid-N,N-diacetic acid (GLDA); aspartic acid-N,N-diacetic acid (ASDA) and alkali metal, alkaline earth metal, transition metal and/or ammonium salts thereof. THICKENER
    [0125] The composition may optionally include a thickener. Exemplary thickeners include (1) cellulosic thickeners and their derivatives, (2) natural gums, (3) starches, (4) stearates, and (5) fatty acid alcohols. Some non-limiting examples of cellulosic thickeners include carboxymethyl hydroxy ethyl cellulose, cellulose, hydroxy butyl methyl cellulose, hydroxy ethyl cellulose, hydroxy propyl cellulose, hydroxy propyl methyl cellulose, methyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and the like. Some non-limiting examples of natural gums include acacia, calcium carrageenan, guar, gelatin, guar gum, hydroxy propyl guar, karaya gum, seaweed, locust bean gum, pectin, sodium carrageenan, gum tragacanth, xanthan gum, and the like. Some non-limiting examples of starches include cereal flour, potato starch, wheat flour, wheat friend, and the like. Some non-limiting examples of stearates include PEG-150 distearate, PEG-22 methoxy/dodecyl glycol copolymer, and the like. Some non-limiting examples of fatty acid alcohols include caprylic alcohol, cetearyl alcohol, lauryl alcohol, oleyl alcohol, palm kernel alcohol, and the like.
    [0126]The proportion of thickener in the composition depends on the desired viscosity of the composition. FRAGRANCE
    [0127]The composition may optionally include a fragrance. Examples of possible fragrances include, but are not limited to, natural oils or naturally derived materials, and synthetic fragrances such as hydrocarbons, alcohols, aldehydes, ketones, esters, lactones, ethers, nitriles, and polyfunctionals. Non-limiting examples of natural oils include: basil oil (Ocimum basilicum), laurel oil (Pimento acris), monarda oil (Monarda didyma), bergamot oil (Citrus aurantium bergamia), cardamom oil (Elettaria cardamomum), oil cedar (Cedrus atlantica), chamomile oil (Anthemis nobilis), cinnamon oil (Cinnamomum cassia), citronella oil (Cymbopogon nardus), sage oil (Salvia sclarea), clove oil (Eugenia caryophyllus), leaf oil clove (Eufenia caryophyllus), Cyperus esculentus oil, cypress oil (Cupressus sempervirens), Eucalyptus citriodora oil, Geranium maculatum oil, ginger oil (Zingiber officinale), grapefruit oil (Citrus grandis), hazelnut oil ( Corylus avellana), jasmine oil (Jasminum officinale), Juniperus communis oil, Juniperus oxycedrus tar, Juniperus virginiana oil, kiwi water (Actinidia chinensis), lavender oil (Lavandula hybrida), lavender oil (Lavandula angustifolia) , water of lavender (Lavandula angustifolia), lemon oil (Citrus medica limonum), lemon grass oil (Cymbopogon schoenanthus), lime oil (Citrus aurantifolia), lime oil (Tilia cordata), linden water (Tilia cordata), oil of mandarin (Citrus nobilis), nutmeg oil (Myristica fragrans), orange flower oil (Citrus aurantium dulcis), orange oil (Citrus aurantium dulcis), orange water (Citrus aurantium dulcis), patchouli oil (Pogostemon cablin), peppermint oil (Menthe piperita), peppermint water (Menthe peperita), rosemary oil (Rosmarinus officinalis), rose oil, rose extract (Rosa damascena), rose extract (Rosa multiflora) , rosewood extract (Aniba rosaeodora), sage oil (Salvia officinalis), sandalwood oil (Santalum album), spearmint oil (Menthe viridis), tea tree oil (Melaleuca alternifolia), and ylang oil ( Cananga odorata). Some non-limiting examples of synthetic hydrocarbon fragrances include caryophyllene, β-farnesene, limonene, α-pinene, and β-pinene. Some non-limiting examples of synthetic alcohol fragrances include bacdanol, citronellol, linalool, phenethyl alcohol, and α-terpineol (R=H). Some non-limiting examples of synthetic aldehyde fragrances include 2-methyl undecanal, citral, hexyl cinnanic aldehyde, isocicolcitral, lilial, and 10-undecanal. Some non-limiting examples of synthetic ketone fragrances include cashmere, α-ionone, isocyclemone E, koavone, muscone, and tonalide. Some non-limiting examples of synthetic ester fragrances include benzyl acetate, 4-t-butylcyclohexyl acetate (cis and trans), cedril acetate, cyclacet, isobornyl acetate, and α-terpinyl acetate (R=acetyl). Some non-limiting examples of synthetic lactone fragrances include coumarin, jasmine lactone, muskalactone, and pear aldehyde. Some non-limiting examples of synthetic ether fragrances include ambroxan, anther, and galaxolide. Some non-limiting examples of synthetic nitrile fragrances include cinnamon nitrile and gernonitrile. Finally, some non-limiting examples of synthetic polyfunctional fragrances include amyl salicylate, isoeugenol, hedione, heliotropine, liral and vanillin.
    [0128] The composition may include a blend of fragrances including a blend of natural and synthetic fragrances. The fragrance may be present in a composition in a proportion of up to about 5% by weight, preferably from 0 to about 3% by weight, from about 0 to about 1% by weight, and from about 0 to about 0.2% by weight. DYE
    [0129] The composition may optionally include a colorant. Examples of dyes include any water soluble or product soluble dye, any FD&C or D&C approved dye. COMPOSITIONS PRODUCTION METHODS
    [0130] The compositions of the invention are easily produced by any of a number of known techniques. Conveniently, a portion of the water is supplied to a suitable mixing vessel additionally provided with a mixer or stirrer, and during stirring, the remaining constituents are added to the mixing vessel, including any final proportion of water necessary to provide 100%, in weight, of the inventive composition.
    [0131] The compositions may be packaged in any suitable container, particularly bottles or bottles, including squeeze or pump type bottles, as well as bottles provided with a spray apparatus (e.g., trigger spray) that is used to dispense the composition by sprinkling. The selected package can have a pumphead foamer. Examples of commercially available pumphead foamers include the F2 foamer available from Rexam PLC (London, England, formerly Airspray), and the RF-17 Palm Foamer available from Rieke Corporation (Auburn, Indiana, USA). Correspondingly, the compositions are desirably provided as concentrates or products ready for use in manual or automated dispensing equipment.
    [0132]The composition can be provided in various sizes of packaging. Examples of pack sizes include 44 ml (1.5 oz), 500 ml and 1 liter bottles.
    [0133] While the compositions of the present invention are intended to be used in the types of liquid forms described, no part of this specification is to be understood as limiting the use of the composition according to the invention with an additional proportion of water to form a solution from it. Conversely, no part of this descriptive report should be understood as limiting the formation of a “super-concentrated” composition based on the composition described above. This super-concentrated ingredient composition is essentially the same as the compositions described above except that they include a smaller proportion of water. METHODS USING THE COMPOSITIONS
    [0134] The invention includes compositions and methods for reducing the population of microorganisms in the skin, a method for treating a skin disease, and the like. These compositions and methods can operate by bringing the body into contact with a composition of the invention. Contacting can include any of a number of methods for applying a composition of the invention, such as spraying the compositions, dipping, foaming or gelling the skin with the composition, or a combination thereof. The compositions and methods can be used without further dilution with water or other suitable diluents or can be provided as concentrated compositions.
    [0135] The compositions of the invention can be included in any skin application products such as sanitizers, deodorants, antiseptics, fungicides, germicides, virucides, waterless hand antiseptics, and pre- or post-surgical brushes, pre-preparations skin operatives. MODALITIES OF THE PRESENT INVENTION
    [0136] The antimicrobial composition of the present invention has a highly broad spectrum of antimicrobial effectiveness, adequate foam volume during washing and foam structure that leads to a dense, rigid and stable foam desired by consumers and low irritability to mammalian tissue. Exemplary compositions are provided in the table below.TABLE A - Antimicrobial composition with improved foam profile (expressed as percentage by weight of actives) (pH 5.0 to 6.7)

    EXAMPLES
    [0137] The present invention is more particularly described in the following examples which are intended for illustration only, since various modifications and variations in the scope of the present invention will become apparent to individuals skilled in the art. Except where noted otherwise, all parts, percentages and ratios reported in the examples below are on a weight basis, and all reagents used in the examples were obtained, or are available, from the chemical suppliers described below, or can be synthesized by conventional techniques.
    [0138] The following methods were used in preparing and testing the examples: ANTIMICROBIAL AND MICROBIAL EFFECTIVENESS:
    [0139](a) Determination of Time Killing Activity: The activity of the antimicrobial compositions was measured by the time killing method [ASTM E 2315 Standard Guide for Assessment of Antimicrobial Activity Using a Time Kill Procedure], whereby the survival of challenged organisms exposed to an antimicrobial test composition is deterred as a function of time. In this test, a diluted aliquot of the composition is contacted with a known population of test bacteria for a specified period of time at a specified temperature. The test composition is neutralized at the end of the time period, which controls the antimicrobial activity of the composition. The percentage or, alternatively, the logarithmic reduction is calculated from the original bacterial population. In general, the method of time extermination is known to those skilled in the art. In addition, comparative data on the foam profile of representative systems is shown.
    [0140](b) The composition can be tested at any concentration from 0 to 100%. The choice of which concentration to use is at the discretion of the investigator, and the appropriate concentrations are readily determined by individuals skilled in the art. All tests are performed in triplicates, the results are combined, and the mean log reduction is reported.
    [0141](c) the choice of the contact time period is also at the researcher's discretion. You can choose any contact time period. Typical contact times range from 10 seconds to 5 minutes, with 30 seconds and 1 minute being typical contact times. The contact temperature can also be any temperature, typically room temperature, or about 25 degrees Celsius.
    [0142](d) The microbial suspension, or test inoculum, is prepared by growing a microbial culture on any suitable solid medium (eg, agar). The microbial population is then washed from the agar with a sterile physiological saline solution and the microbial suspension population is adjusted to about 108 colony forming units per ml (cfu/ml).
    [0143](e) The table below lists the microbial test cultures used in the following tests and includes the name of the bacteria, the ATCC (American Typical Culture Collection) identification number, and the abbreviation for the name of the organism used plus later in this document.

    S. aureus is a Gram positive bacterium, while E. coli is a Gram negative bacterium. Logarithmic reduction is calculated using the formula: Logarithmic reduction = logw (control numbers) - logio (test sample survivors). DETERMINING THE HEIGHT OF THE FOAM
    [0144] The foam height was determined with the following procedural steps:
    [0145]1. Prepare a 1% solution of the product in water from 5 grains.
    [0146]2. Pour 150 mL of the solution into a blender
    [0147]3. Blend on medium speed for 10 seconds.
    [0148]4. Pour into a 1000 mL beaker and measure the height of the foam.
    [0149]5. Measure the foam height in 3 and 5 minutes. DETERMINATION OF FOAM STRENGTH
    [0150] The foam strength was determined by measuring 40 grams of the test product in a mixer and mixing for about 30 seconds at medium speed. Subsequently, the test solution was poured into a cylinder and a plastic ball was placed in the test solution and timed to determine how many seconds it took for the plastic ball to move from a predetermined first level to a second level predetermined, for example, from the marking of 100 ml on the cylinder to the marking of 40 ml on the cylinder.
    [0151]The following table reports various formulations made and tested. Note that the percentages reported in this section are only the total percentages of components as received from commercial vendors and in these tables, include inert ingredients such as water or salts. In each instance where this occurs, the percentage of active component in the product as received from the commercial seller is listed and the percentage assets can be easily calculated from this information. Formulation Examples 1-12, 17-18
    TABLE #1: Exemplary Formulations 1-12, 17-18 Efficacy Test Results
    TABLE #2: Results of Antimicrobial Efficacy from Examples 1-3
    [0152] The efficacy test results in Table 2 demonstrate that introducing foam structure enhancing agents such as PEG 8000, Hexylene Glycol, and Myristamide diisoamidopropyl amide or a combination thereof does not interfere with the antimicrobial effectiveness of the cationic active, benzalkonium chloride .RESULTS OF THE FOAM HEIGHT TEST OF EXAMPLES 1-11
    [0153] The foam heights of the formulations were determined by preparing a 1% solution and using a rotational device. The device was rotated for 2 minutes and the foam height was recorded after 30 seconds, 3 and 5 minutes.
    TABLE #3: Foam Height Result for Examples 1-11, 17-18
    [0154] As shown in table 3, formulation example 7 had a significantly higher foam height that had the contribution of the foam enhancing agent, Caprilate/Glyceryl Caprate. Therefore, Caprilate/Glyceryl Caprate is a primary foaming agent in the preferred formula. It is also shown in table 3 that the formulation example 11 exhibits a higher foam height, this is due to the combination of foam enhancing components and foam structure enhancing components such as; Glyceryl Caprilate, Polyethylene 8000, Hexylene Glycol, and Myristamide Diisopropanolamide, you can get the ideal foam height. It is also shown in table 3, an example of formulation 18, that it is essential to have a compatible cationic surfactant for foam generation.RESULTS OF DETERMINING FOAM STRENGTH
    [0155] The foam strength was determined by measuring 40 mls of the test product in a mixer and mixing for about 30 seconds at medium speed. The test solution was poured into a graduated cylinder and a plastic ball was placed in the test solution and timed to determine how many seconds it took for the plastic ball to move from the 100 mL mark on the cylinder to the mark 40 mL. FIGURE 1: foam stiffness and strength results from examples 1-5, 8, 9, 11 and 12
    [0156] As shown in figure 1, formulation example 2 has the stiffest foam when compared to formulation examples 1, 4, 8 and 12. Therefore, Polyethylene Glycol 8000 is a primary contributor to the rigidity and strength of the foam. It is also shown in figure 1 by formulation example 3 that the combination of Polyethylene Glycol and Hexylene Glycol is essential for the rigidity and strength of the foam. Optimum foam rigidity and strength can be achieved by combining a foam enhancing agent such as Caprilate/Glyceryl Caprate and foam structure enhancing components such as Polyethylene 8000, Hexylene Glycol, and Myristamide Diisopropanolamide,


    EXAMPLES 13-15 ARE BASED ON CATIONIC ACTIVE FORMULAS. EFFECTIVENESS RESULTS OF EXAMPLES 13-15
    TABLE #4: Antimicrobial Efficacy Results of Examples 13-15
    [0157]Exemplary formulations 13, 14 and 15 are various formulations based on the cationic active. Exemplary formulation 15 contains unique foam enhancing agents and foam structure enhancers. The addition of these innovative agents improves the aesthetic profile of the product, thus improving the acceptability of the product by consumers without harming the antimicrobial effectiveness of the cationic active. As seen in Table 4, all formulations maintained high acidic antimicrobial efficacy. The 15-second test of Example 15 was performed on a different day from the 30-second tests. Therefore, there were likely differences in bacterial populations, which may contribute to the differences in logarithmic reduction between the 30-second test and the 15-second test data.EXAMPLES FOAM HEIGHT TEST RESULTS 13-15
    TABLE #5: Foam Height Measurements from Examples 13-15
    [0158]Example 15 has a significantly higher foam height in 30 s, 3 and 5 minutes compared to formulation examples 13 and 14. This demonstrates that the addition of foam enhancing agents and foam structure enhancers, Caprilate/Caprate of Glyceryl, PEG 8000 and Hexylene Glycol, Myristamide Diisopranolamide to the cleaning composition increases foam height, thereby increasing consumer product preference. 1315
    [0159] Example 15 has the stiffest foam compared to formulation examples 13 and 14. This demonstrates the addition of foam enhancing agents and foam structure enhancers such as Caprilate/Glyceryl Caprate, PEG 8000 and Hexylene Glycol and Myristamide Diisopranolamide to the cleaning composition increases foam rigidity and foam strength, thus increasing consumer product preference. PANEL TEST
    [0160] The development of the antimicrobial composition containing cationic active ingredient, cationic compatible surfactant, foam enhancing agent, foam structure enhancing agent, and skin conditioning agent with the ideal addition of preservative, pH adjustment additive and fragrance was submitted to a panel test to determine its aesthetic acceptability to consumers.
    [0161]During the first session, about 40 candidates tested the cosmetic attributes of formulation example 13 compared to formulation example 14. Candidates were asked to wash their hands with normal soap to normalize the skin between candidates, then, dirt was applied to the hands and they proceeded with washing with the test products. FIGURE 3: Panel test results of example 13 vs. example 14
    [0162]The panelist preferred formulation example 14 to formulation example 13 by almost 50%. This corresponds to the foam height results (table 5) and the foam stiffness and strength results (figure 2) where formulation 14 fared better than formulation 13. Therefore, improved foam height and foam stiffness confirm a better aesthetic foam profile that can be translated into consumer preference.
    [0163]During the second session, 30 candidates tested the cosmetic attributes of Formulation Example 15 with unique foam enhancing agents and foam structure enhancers, compared to commercially available Triclosan active foaming hand soaps.FIGURE 4: results of 15 vs. formulation example panel test. commercially available foaming hand soaps.
    [0164] As noted by the above results, formulation example 15 with exclusive foam enhancers and foam structure enhancers is more preferred than commercial product 1 and equally preferred to commercial product 2.
    [0165]From the panel tests conducted, and the results of the foam height and foam stiffness, it has been proven that the addition of unique foam enhancing agents and foam structure enhancers improves the aesthetic profile of the formula thus leading to , to consumer acceptability while maintaining the required antimicrobial efficacy. ANTIMICROBIAL ACTIVE pH DEPENDENCE
    [0166]The activity of the cationic antimicrobial active depends on the final pH of the cleaning composition. Figure 5 shows the results of the antimicrobial effectiveness of formulation example 15 at various pH ranges (5.50 to 7.0) FIGURE 5: pH range of antimicrobial effectiveness of formulation example 15 at exposure time of 30 s
    [0167]The results of the efficacy test show that the antimicrobial efficacy depends on the pH of the formulation. Within the pH range of 5.75 to 7.0, the cleaning composition effectively reduces microbial populations, is stable in phase, generates a foam stable during washing and is gentle on the skin.ALTERNATIVE CATIONIC ACTIVE INGREDIENTS
    TABLE # 7: Antimicrobial Efficacy of Various Cationic Assets
    [0168]Table 7 illustrates the effectiveness of four different cationic actives formulated independently in the composition of formulation example 15 at pH 6.25. All actives have a high antimicrobial activity against S.aureus and E.coli bacteria in an exposure time of 30 seconds.
    EFFECTIVENESS RESULTS OF FORMULATION EXAMPLE 16

    [0169] Formulation example 16 shows that the antimicrobial activity of S. aureus was reduced to "No detectable reduction" when the antimicrobial cationic biocide was removed. Therefore, it can be concluded that the composition must have an antimicrobial active in order to be efficient.
    [0170] The antimicrobial compositions of the present invention have several practical end uses, including hand cleaning solutions, surgical brushes, hand sanitizers, and similar personal care products. Additional types of compositions include foaming compositions such as creams, mousses, and the like. The present antimicrobial compositions can be manufactured as ready-to-use diluted compositions, or as concentrates that are diluted before use, or when used. Dilution can occur manually or through automated dispensing and/or dilution equipment.
    [0171] Many modifications and variations of the invention as set forth above herein may be made without departing from the spirit and scope of the invention, and therefore only these limitations shall be imposed as indicated by the appended claims.
    权利要求:
    Claims (15)
    [0001]
    1. Foaming antimicrobial dermal cleaner, CHARACTERIZED by the fact that it comprises: a. a cationic active ingredient; b. a cationic compatible surfactant, wherein the cationic compatible surfactant is an alkyl amine oxide and/or an alkyl ether amine oxide; c. from 0.01% by weight to 1% by weight of a foaming agent; wherein said foaming agent is selected from the group consisting of: glyceryl caprate/caprylate, sorbinate sesquicaprylate, phospholipids , polyethylene glycol dimethicone with methyl esters, polyethylene glycol-7-glyceryl cocoate, caprylic/capric monoglycerides, hydrophobically modified cationic polymers and combinations thereof; d. from 0.01% by weight to 8% by weight of a foam structure enhancing agent; e. a skin conditioning agent, wherein the skin conditioning agent comprises one or more of glycerin, vitamin E acetate, methyl glucet 20 and hydroxypropyl guar hydroxy propyltrimonium chloride; and water, wherein said cleaner is substantially free of anionic surfactants and triclosan.
    [0002]
    2. Foaming antimicrobial dermal cleaner according to claim 1, CHARACTERIZED by the fact that the foaming antimicrobial dermal cleaner comprises from 0.01% by weight to 10% by weight of at least one of the cationic active ingredients.
    [0003]
    3. Foaming antimicrobial dermal cleanser according to claim 1 or 2, CHARACTERIZED by the fact that the cationic active ingredient is selected from the group comprising: a salt of a biguanide, substituted biguanide, an organic salt of a compound containing quaternary ammonium or an inorganic salt of a compound containing quaternary ammonium, and an organic salt of chlorhexidene, chlorhexidene digluconate.
    [0004]
    4. Foaming antimicrobial dermal cleaner according to any one of claims 1 to 3, CHARACTERIZED by the fact that the surfactant component includes from 0.1% by weight to 12.5% by weight of an alkyl oxide amine and/or alkyl ether amine oxide.
    [0005]
    5. Foaming antimicrobial dermal cleaner according to any one of claims 1 to 4, CHARACTERIZED by the fact that the foam enhancing agent comprises glyceryl caprate/caprylate
    [0006]
    6. Foaming antimicrobial dermal cleaner, according to any one of claims 1 to 5, CHARACTERIZED by the fact that the foam structure enhancing agent comprises polyethylene glycol 8000, hexylene glycol, myrsiamide diisopronolaiamide and phenoxyethanol.
    [0007]
    7. Foaming antimicrobial dermal cleaner, according to any one of claims 1 to 6, CHARACTERIZED by the fact that said foam structure enhancing agent is hexylene glycol.
    [0008]
    8. Foaming antimicrobial dermal cleaner, according to any one of claims 1 to 7, CHARACTERIZED by the fact that said foam structure enhancing agent comprises phenoxyethanol.
    [0009]
    9. Method for reducing bacterial, microbial, fungal or viral population in a dermal tissue of a mammal, CHARACTERIZED by the fact that it comprises the step of: placing the dermal tissue of a mammal in contact with the foaming antimicrobial dermal cleaner, as defined in any one of claims 1 to 8, for a time sufficient to provide substantial bacterial, microbial, fungal or viral reduction, wherein the sufficient time is from 5 seconds to 10 minutes.
    [0010]
    10. Method according to claim 9, CHARACTERIZED by the fact that the sufficient contact time is approximately 5 to 60 seconds.
    [0011]
    11. Method according to claim 9 or 10, CHARACTERIZED by the fact that the foaming antimicrobial dermal cleaner is rinsed from the dermal tissue after contact or remains in the dermal tissue after contact.
    [0012]
    12. Foaming antimicrobial dermal cleaner, CHARACTERIZED by the fact that it comprises: a. a cationic active ingredient; b. from 0.1% by weight to 5% by weight of a cationic compatible surfactant wherein the cationic compatible surfactant is an alkyl amine oxide and/or an alkyl ether amine oxide; c. from 0.01% by weight to 1% by weight of a foam enhancer, wherein said foam enhancer is selected from the group consisting of: glyceryl caprate/caprylate, sorbinate sesquicaprylate, phospholipids, polyethylene glycol dimethicone with methyl esters, polyethylene glycol-7-glyceryl cocoate, caprylic/capric monoglycerides, hydrophobically modified cationic polymers and combinations thereof; d. from 0.01% by weight to 8% by weight of a foam structure enhancing agent, e.g. a dermal adjuvant; and water, wherein said cleaner is substantially free of anionic surfactants, lower alcohols and triclosan.
    [0013]
    13. Foaming antimicrobial dermal cleaner, according to claim 12, CHARACTERIZED by the fact that the foam structure enhancing agent comprises one or more of the following: polyethylene glycol 8000, hexylene glycol, mirsiamide diisopronolamide and phenoxyethanol.
    [0014]
    14. Foaming antimicrobial dermal cleaner according to claim 12 or 13, CHARACTERIZED by the fact that one or more foam structure enhancing agents include hexylene glycol.
    [0015]
    15. Foaming antimicrobial dermal cleaner, according to any one of claims 12 to 14, CHARACTERIZED by the fact that it also comprises a preservative.
    类似技术:
    公开号 | 公开日 | 专利标题
    BR112017002131B1|2021-07-27|SPARKLING ANTIMICROBIAL DERMIC CLEANER AND METHOD TO REDUCE BACTERIAL, MICROBIAL, FUNGAL, OR VIRAL POPULATION IN A MAMMALIAN DERMIC TISSUE
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    同族专利:
    公开号 | 公开日
    WO2016019174A1|2016-02-04|
    US20180256466A1|2018-09-13|
    CN106687101A|2017-05-17|
    JP2017522356A|2017-08-10|
    JP6431180B2|2018-11-28|
    EP3174518A1|2017-06-07|
    AU2018214102A1|2018-08-30|
    US9956153B2|2018-05-01|
    AU2018214102B2|2020-03-12|
    AU2015296250B2|2018-05-31|
    MX2017001517A|2017-05-08|
    CA2956935C|2018-12-11|
    US10517806B2|2019-12-31|
    EP3174518A4|2018-03-21|
    US20160030315A1|2016-02-04|
    BR112017002131A2|2017-11-21|
    AU2015296250A1|2017-02-16|
    CA2956935A1|2016-02-04|
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    法律状态:
    2019-08-27| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-08-18| B07A| Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]|
    2021-03-02| B06A| Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]|
    2021-05-18| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-07-27| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/07/2015, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US14/449,895|2014-08-01|
    US14/449,895|US9956153B2|2014-08-01|2014-08-01|Antimicrobial foaming compositions containing cationic active ingredients|
    PCT/US2015/042969|WO2016019174A1|2014-08-01|2015-07-30|Antimicrobial foaming compositions containing cationic active ingredients|
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