• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The present invention relates to a fungicidal composition which contains a fungicidally effective amount of a compound of formula I, (3s,6s,7r,8r)-8-benzyl-3-(3-((isobutyryloxy)methoxy) isobutyrate -4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl and at least one fungicide selected from the group consisting of prothioconazole, epoxiconazole, cyproconazole, myclobutanil, prochloraz, metconazole, difenconazole, tebuconazole, tetraconazole, fenbuconazole, propiconazole, fluquinconazole, flusilazole, flutriafol and fenpropimorph.
    公开号:BR112017000066B1
    申请号:R112017000066-0
    申请日:2015-08-08
    公开日:2021-06-22
    发明作者:Thomas Schulz
    申请人:Dow Agrosciences Llc；
    IPC主号:
    专利说明:

    Cross Reference to Related Patent Applications
    [001] This patent application claims the benefit of Provisional Patent Application Serial No. US 62/035,198, filed August 8, 2014, which is incorporated herein by reference. Field
    [002] The present invention relates to a synergistic fungicidal composition containing (a) a compound of Formula I, (3S,6S,7R,8R)-8-benzyl-3-(3-((isobutyryloxy)methoxy) isobutyrate -4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-ila and (b) at least one ergosterol biosynthesis inhibitor fungicide selected from the group consisting of prothioconazole, epoxiconazole, cyproconazole, Meclobutanil, prochloraz, metconazole, difenconazole, tebuconazole, tetraconazole, fenbuconazole, propiconazole, fluquinconazole, flusilazole, flutriafol and fenpropimorph. Background
    [003] Fungicides are compounds, of natural or synthetic origin, which act to protect plants against damage caused by fungi. Current farming methods rely heavily on the use of fungicides. In fact, some crops cannot be usefully grown without the use of fungicides. The use of fungicides allows a producer to increase the yield and quality of the crop and, consequently, increase the value of the crop. In most situations, the increase in crop value is worth at least three times the cost of using the fungicide.
    [004] However, no one fungicide is useful in all situations and the repeated use of a single fungicide often leads to the development of resistance to that and related fungicides. Consequently, research is being conducted to produce safer, better performing fungicides and fungicide combinations that require lower dosages, are easier to use and cost less.
    [005] Synergism occurs when the effect of two or more compounds exceeds the effect of the compounds when used alone. summary
    [006] It is an objective of the present invention to provide synergistic compositions comprising fungicidal compounds. It is a further object of the present invention to provide processes using these synergistic compositions. The synergistic compositions are capable of preventing or curing, or both, diseases caused by fungi of the Ascomycetes and Basidiomycetes classes. In addition, the synergistic compositions are capable of providing improved growth in crops, where the growth improvement is characterized by at least one of the effects selected from the group consisting of preventing or curing pathogenic fungi and improving plant physiology, in which the Improved plant physiology is characterized by at least one of the effects selected from the group consisting of improved root growth, improved greening, better water utilization and efficiency, greater nitrogen use efficiency, senescence delay, and increased water efficiency. Yield. In accordance with this description, synergistic compositions are provided along with methods for their use. Detailed Description
    The present invention relates to a synergistic fungicidal mixture comprising a fungicidally effective amount of (a) a compound of Formula I, (3S,6S,7R,8R)-8-benzyl-3-(3) isobutyrate - ((isobutyryloxy)methoxy)-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-ila and (b) at least one ergosterol biosynthesis inhibiting fungicide selected from the group which consists of prothioconazole, epoxiconazole, cyproconazole, myclobutanil, prochloraz, metconazole, difenconazole, tebuconazole, tetraconazole, fenbuconazole, propiconazole, fluquinconazole, flusilazole, flutriafol, and fenpropimorph.

    [008] As used in the present invention, prothioconazole is the common name of 2-[(2RS)-2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2H-1,2, 4-triazol-3 (4H)-thione and has the following structure:

    [009] Its fungicidal activity is described in the Pesticide Manual, 15th Edition, 2009. Prothioconazole provides the control of diseases such as Acama mada (pseudocercosporella herpotrichoides), Fusarium (Fusarium spp., Microdochium nivale), leaf spot diseases (Septoria tritici, Leptosphaeria nodorum, Pyrenophora spp., Rhynchosporium secalis, etc.), rust (Puccinia spp.) and powdery mildew (Blumeria graminis), through foliar application, on wheat, barley and others cultures.
    [0010] In the compositions described in the present invention, the weight ratios of the compound of Formula I in which synergistic effects with the other fungicides are observed are within the ratio of about 1:10 and 10:1.
    [0011] In one embodiment, the weight ratio of the compound of Formula I to the other fungicides in which the fungicidal effect is synergistic is within the ratio of between about 1:5 to about 5:1 and, in in another embodiment, the weight ratio is in the ratio of about 1:2 to about 1:1, and in yet another embodiment, the weight ratio is in the ratio of about 100:195 to about 130 : 195. In yet another embodiment, the weight ratios described in the present invention are given for a compound of Formula I and other fungicides, wherein prothioconazole is representative of the other fungicides.
    [0012] In the compositions described in the present invention, the proportion by weight of the compound of Formula I wherein the improved plant physiology is synergistic, wherein the improved plant physiology is characterized by at least one of the effects selected from the group consisting of root growth increased, improved greening, better water utilization and efficiency, greater nitrogen use efficiency, delayed senescence and improved yield, for other fungicides it is within the ratio of about 1:10 to about 10:1 .
    [0013] In one embodiment, the weight ratio of the compound of Formula I to the other fungicides where the improved plant physiology effect is synergistic, where the improved plant physiology effect is the improved yield, is within the ratio of about 1:5 to about 5:1 and in another embodiment, the weight ratio of the compound of Formula I in which the synergistic yield increase is observed with the other fungicides is within the ratio of about 1: 2 and about 1:1. In another embodiment, the weight ratio of the compound of Formula I to the other fungicides to which the improved plant physiology effect is synergistic, wherein the improved physiological effect of the plant is characterized by an increase in greening of plant tissue, is within the ratio of about 1: 5 to about 5:1 and in another embodiment, the weight ratio of the compound of Formula I in which the effect of greening is observed with the other fungicides. within the ratio of about 1:2 and about 1:1. In yet another embodiment, the weight ratios described in the present invention are indicated for a compound of Formula I and other fungicides, wherein prothioconazole is representative of the others. fungicides.
    [0014] The speed at which the synergistic composition is applied will depend on the particular type of fungus to be controlled, the degree of control required and the timing and method of application. In general, the composition of the description can be applied at an application rate of between about 25 grams per hectare (g/ha) and about 850 g/ha based on the total amount of active ingredients in the composition.
    [0015] The synergistic composition comprising the compound of Formula I and prothioconazole is applied at a rate between about 60 g/ha and about 600 g/ha. Prothioconazole is applied at a rate between about 25 g/ha and about 300 g/ha and the compound of Formula I is applied at a rate between about 35 g/ha and about 300 g/ha. In a more particular embodiment, prothioconazole is applied at a rate of between about 100 g/ha and 200 g/ha, even more particularly about 195 g/ha, and the compound of Formula 1 is applied at a rate of between about about 75 g/ha and 150 g/ha, even more particularly between about 100 g/ha and 130 g/ha.
    [0016] The components of the synergistic mixture of the present description can be applied separately or as part of a multi-part fungicidal system.
    [0017] The synergistic mixture of the present invention can be applied together with one or more fungicides to control a wider variety of undesirable diseases. When used in conjunction with other fungicides, the presently claimed compounds may be formulated with the other fungicide(s), tank mixed with the other fungicide(s) or applied sequentially with the (s) other (s) fungicide (s). Such other fungicides may include 2-(thiocyanatomethylthio)-benzothiazole, 2-phenylphenol, 8-hydroxyquinoline sulfate, amethoctradine, amisulbrom, antimycin, Ampelomyces quisqualis, azaconazole, azoxystrobin, Bacillus subtilis, Bacillus subtilis strain QST713, benalaxyl, benalaxyl, benomyl benzylaminobenzenesulfonate (BABS), bicarbonates, biphenyl, bismerthiazole, bitertanol, bixafen, blasticidin-S, borax, Bordalesa syrup, boscalide, bromuconazole, bupirimate, calcium polysulfide, captafol, captan, carbendazim, carboxyvone, carpopamide, Chlorazelamine, chlorazepine, chlorophenone, cloneb, chlorothalonil, chlozolinate, Coniothyrium minitans, copper hydroxide, copper octanoate, copper oxychloride, copper sulfate, copper sulfate (tribasic), cuprous oxide, cyazofamid, cyflufenamide, cymoxanil , cyproconazole, cyprodinil, dazomet, debacarb, ethylenebis(dithiocarbamate) diammonium, dichlofluanid, dichlorophene, diclocimet, diclomezine, dichlorane, dietof enamide, difenoconazole, difenzoquat ion, diflumethorim, dimethomorph, dimoxystrobin, diniconazol, diniconazol-M, dinobutane, dinocap, diphenylamine, ditianon, dodemorph, dodemorph acetate, dodine, dodine free base, ediburinestrone, estronestrone , epoxiconazole, ethaboxam, ethoxyquin, etridiazol, famoxadone, fenamidone, fenarimol, fenbuconazole, fenfuram, fenhexamide, fenoxanil, fenpiclonil, fenpropidin, fenpropimorph, fenpirazamine, fentin, fentin hydroxide, fentin - rimzone, fluazinam, fludioxonil, flumorph, fluopicolide, fluopyr, fluoroimide, fluoxastrobin, fluquinconazole, flussilazol, flusulfamide, fluthianil, flutolanil, flutriafol, fluxapiroxad, folpet, formaldehyde, fosetyl, furinium, ethyl-alum , furametpyr, guazatine, guazatine acetates, GY-81, Hexachlorobenzene, hexaconazole, himexazol, imazalil, imazalyl sulfate, imibenconazol, iminoctadine, iminoctadine triacetate, iminoctadine tris(a). lbesylate), iodocarb, ipconazole, ipfenpyrazolone, iprobenfos, iprodione, iprovalicarb, isoprothiolane, isopirazam, isotianil, kasugamycin, kasugamycin hydrochloride hydrate, kresoxim-metyl, laminarin, methicil, mancophenam, mancophenam Meptyl-dinocap, mercuric chloride, mercuric oxide, mercuric chloride, metalaxyl, metalaxyl-M, metam, metam-ammonium, metam-potassium, metam-sodium, metonazol, metasulfocarb, methyl iodide, methyl isothiocyanate, , metaminostrobin, metraphenone, mildiomycin, myclobutanil, nabam, nitrothal-isopropyl, nuarimol, octilinone, ofurace, oleic acid (fatty acids), orysastrobin, oxadixyl, oxine-copper, oxpoconazole fumarate, peoxy-carboxylate , penconazole, pencycuron, penflufen, pentachlorophenol, pentachlorophenyl laurate, penthiopyrad, phenylmercury acetate, phosphonic acid, phthalide, picoxystrobin, polyoxin B, polyoxins, polyoxorim, potassium bicarbonate, sulfate d and potassium hydroxyquinoline, probenazole, prochloraz, procymidone, propamocarb, propamocarb hydrochloride, propiconazole, propineb, proquinazid, prothioconazole, pyraclostrobin, pyramethostrobin, pyraoxystrobin, pyrazolophos, pyribencarbime, pyriconazole, pyriconazole, pyroquinoline , quinoxyfen, quintazene, Reynoutria sachalinensis extract, sedaxane, silthiofam, simeconazole, sodium 2-phenylphenoxide, sodium bicarbonate, sodium pentachlorophenoxide, spiroxamine, sulfur, SYP-Z048, tar oils, tebuconazole, tebufloquin, tetraabazole, techazolnazen , thifluzamide, thiophanate-methyl, tyram, tiadinil, tolclophosmethyl, tolylfluanid, triadimephone, triadimenol, triazoxide, tricyclazole, tridemorph, trifloxystrobin, triflumizole, triforine, triticonazole, validamycin, vazonozine, valifexline olophila, Fusarium oxysporum, Gliocladium spp., Phlebiopsis gigantea, Streptomyces griseoviridis, Trichode rma spp., (RS)-N-(3,5-dichlorophenyl)-2-(methoxymethyl)succinimide, 1,2-dichloropropane, 1,3-dichloro-1,1,3,3-tetrafluoroacetone hydrate, 1-chloro-2,4-dinitronaphthalene, 1-chloro-2-nitropropane, 2-(2-heptadecyl-2-imidazolin-1-yl)ethanol, 2,3-dihydro-5-phenyl-1,4 -dithiine 1,1,4,4-tetraoxide, 2-methoxyethylmercury acetate, 2-methoxyethylmercury chloride, 2-methoxyethylmercury silicate, 3-(4-chlorophenyl)-5-methylrhodanine, 4-(2 -nitroprop-1-enyl)phenyl thiocyanateme, am-propylphos, anilazine, Azitiram, barium polysulfide, Bayer 32394, benodanil, benquinox, bentaluron, benzamacril; benzamacryl-isobutyl, benzamorph, binapacryl, bis(methylmercury) sulfate, bis(tributylstane) oxide, butiobate, calcium cadmium sulfate copper zinc chromate, carbamorph, CESC, clobenthiazone, chloraniformatane, chlorphenazol, chlorquinox, climbazol, copper bis (3-phenylsalicylate), copper chromate zinc, cufraneb, copper hydrazinium sulphate, cuprobam, cyclfuramid, cipendazole, ciprofuram, decafentine, diclone, dichlozoline, diclobutrazol, dimethirimol, dinocton, dinosulfone, dinoterbone, dipyrithion, dicynalymphos, drazoxolon, EBP, ESBP, etaconazole, etem, ethyrim, phenaminosulf, fenpanil, fenitropan, fluotrimazol, furcarbanil, furconazol, furconazol-cis, furmeciclox, furofanate, gliodin, griseofulvin, halacrinate, fluotrimazole, isovamilion 3944, , mebenyl, mecarbinzid, metazoxolon, metfuroxam, methylmercury dicyandiamide, metsulfovax, milneb, mucochloric anhydride, myclozoline, N-3,5-dichlorophenyl-succinimide, N-3-nitrophenylitaconimide , natamycin, N-ethylmercury-4-toluenesulfonanilide, nickel bis(dimethyldithiocarbamate), OCH, phenylmercury dimethyldithiocarbamate, phenylmercury nitrate, phosdiphene, prothiocarb; Prothiocarb hydrochloride, pyracarbolid, pyridinitrile, pyroxychlor, pyroxyfur, quinacetol; quinacetol sulphate, quinazamid, quinconazole, rabenzazole, salicylanilide, SSF-109, sultropen, tecoram, thiadifluor, thiciophen, thiochlorphenfin, thiophanate, thioquinox, thioximid, triamiphos, triarimol, triazbutylmid, triclzaramide, urbacid any combinations thereof.
    [0018] The compositions of the present description are preferably applied in the form of a formulation comprising a composition of (a) a compound of Formula I and (b) at least one ergosterol-fungicide biosynthesis fungicide selected from the group consisting of in prothioconazole, epoxiconazole, cyproconazole, myclobutanil, prochloraz, metconazole, difenconazole, tebuconazole, tetraconazole, fenbuconazole, propiconazole, fluquinconazole, flusilazole, flutriafol and fenpropimorph, together with a phytologically acceptable carrier.
    [0019] Concentrated formulations can be dispersed in water, or other liquid, for application, or formulations can be powder-like or granular, which can then be applied without further treatment. The formulations are prepared according to procedures which are conventional in the agricultural chemical art, but which are new and important due to the presence therein of a synergistic composition.
    [0020] The formulations that are most frequently applied are aqueous suspensions or emulsions. Such water-soluble, water-suspensible or emulsifiable formulations are solids, usually known as wet powders, or liquids, usually known as emulsifiable concentrates, aqueous suspensions or suspension concentrates. The present invention contemplates all vehicles by which the synergistic compositions can be formulated for delivery and use as a fungicide.
    [0021] As will be readily appreciated, any material to which these synergistic compositions may be added can be used, provided it yields the desired utility without significant interference with the activity of these synergistic compositions as antifungal agents.
    Wet powders, which can be compacted to form water-dispersible granules, comprise an intimate blend of the synergistic composition, a carrier and agriculturally acceptable surfactants. The concentration of the synergistic composition in the wet powder is usually from about 10% to about 90% by weight, more preferably about 25% to about 75% by weight, based on the total weight of the formulation. In preparing wet powder formulations, the synergistic composition can be compounded with any of the finely divided solids such as prophyllite, talc, chalk, gypsum, Fuller's earth, bentonite, attapulgite, starch, casein, gluten, montmorilanite clays, earth of diatoms, purified silicates or the like. In such operations, the finely divided support is crushed or mixed with the synergistic composition in a volatile organic solvent. Effective surfactants, comprising from about 0.5% to about 10% by weight of the wet powder, include sulfonated lignins, naphthalenesulfonates, alkylbenzenesulfonates, alkyl sulfates, and nonionic surfactants such as ethylene oxide adducts of alkylphenols.
    The emulsifiable concentrates of the synergistic composition comprise a convenient concentration, such as from about 10% to about 50% by weight, in a suitable liquid, based on the total weight of the emulsifiable concentrate formulation. The components of the synergistic compositions, together or separately, are dissolved in a vehicle, which is a water-miscible solvent or a mixture of water-immiscible organic solvents, and emulsifiers. Concentrates can be diluted with water and oil to form spray mixtures in the form of oil-in-water emulsions. Useful organic solvents include aromatics, especially the high boiling naphthalene and olphinic moieties of petroleum, such as heavy aromatic naphtha. Other organic solvents can also be used, such as, for example, terpenic solvents, including rosin derivatives, aliphatic ketones, such as cyclohexanone, and complex alcohols, such as 2-ethoxyethanol.
    [0024] Emulsifiers that can be used in the present invention advantageously can be readily determined by those skilled in the art and include various nonionic, anionic, cationic and amphoteric emulsifiers, or a mixture of two or more emulsifiers. Examples of nonionic emulsifiers useful in preparing the emulsifiable concentrates include polyalkylene glycol ethers and condensation products of alkyl and arylphenols, aliphatic alcohols, aliphatic amines or fatty acids with ethylene oxide, propylene oxides such as ethoxylated alkylphenols and carboxylic esters solubilized with Polyol or polyoxyalkylene. Cationic emulsifiers include quaternary ammonium compounds and fatty amine salts. Anionic emulsifiers include the oil-soluble (e.g., calcium) salts of alkylarylsulfonic acids, oil-soluble salts or sulfated polyglycol ethers, and appropriate salts of phosphated polyglycol ether.
    [0025] Representative organic liquids that may be used in preparing the emulsifiable concentrates of the present description are aromatic liquids such as xylene, propylbenzene fractions or mixed naphthalene fractions, mineral oils, substituted aromatic organic liquids such as dioctyl phthalate , kerosene, dialkylamides of various fatty acids, particularly the dimethylamides of fatty glycols and glycol derivatives such as n-butyl ether, ethyl ether and diethylene glycol methyl ether, and triethylene glycol methyl ether. Mixtures of two or more organic liquids are also often suitably used in preparing the emulsifiable concentrate. Preferred organic liquids are xylene and propylbenzene fractions, with xylene being most preferred. Surface-active dispersing agents are usually used in liquid formulations and in the amount of 0.1 to 20 percent by weight of the combined weight of the dispersing agent with the synergistic compositions. The formulations can also contain other compatible additives, for example plant growth regulators and other biologically active compounds used in agriculture.
    Aqueous suspensions comprise suspensions of one or more water-insoluble compounds, dispersed in an aqueous vehicle at a concentration in the proportion of about 5% to about 70% by weight, based on the total weight of the aqueous suspension formulation . Suspensions are prepared by finely grinding the components of the synergistic combination either together or separately, and vigorously mixing the ground material into a vehicle consisting of water and surfactants chosen from the same types discussed above. Other ingredients, such as inorganic salts and synthetic or natural gums, can also be added to increase the density and viscosity of the aqueous vehicle. It is often more effective to grind and mix while preparing the aqueous mixture and homogenizing it in a utensil such as a sand mill, ball mill, or piston-type homogenizer.
    [0027] The synergistic composition can also be applied as a granular formulation, which is particularly useful for soil applications. Granular formulations generally contain about 0.5% to about 10% by weight of the compounds, based on the total weight of the granular formulation, dispersed in a vehicle consisting entirely or largely of attapulgite, bentonite, diatomite, clay or a similar and economical substance. Such formulations are usually prepared by dissolving the synergistic composition in a suitable solvent and applying it to a granular support which has been preformed to the appropriate particle size, in the ratio of about 0.5 to about 3 mm. Such formulations can also be prepared by making a mass or paste of the support and the synergistic composition and crushing and drying to obtain the desired granular particle.
    Dusts containing the synergistic composition are prepared simply by intimately mixing the synergistic composition in powder form with a suitable dusty agricultural vehicle such as, for example, kaolin clay, molten volcanic rock and the like. Dusts can suitably contain from about 1% to about 10% by weight of the synergistic composition/vehicle combination.
    [0029] The formulations may contain agriculturally acceptable adjuvant surfactants to increase the deposition, wetting and penetration of the synergistic composition on the crop and the target organism. These adjuvant surfactants can optionally be employed as a component of the formulation or as a tank mix. The amount of adjuvant surfactant will range from 0.01 percent to 1.0 percent by volume/volume (v/v) based on a volume of spray water, preferably 0.05 to 0.5 percent. Suitable adjuvant surfactants include ethoxylated nonylphenols, ethoxylated synthetic or natural alcohols, salts of the sulphosuccinic esters or acids, ethoxylated organosilicones, ethoxylated fatty amines and surfactant mixtures with mineral or vegetable oils.
    The formulations may optionally include combinations which may comprise at least 1% by weight of one or more of the compositions synergistic with another pesticide compound. Such additional pesticide compounds may be fungicides, insecticides, nematocides, acaricides, arthropodicides, bactericides or combinations thereof that are compatible with the synergistic compositions of the present invention in the medium selected for application and not antagonistic to the activity of the present compounds. Therefore, in these embodiments the other pesticide compound is used as an additional toxicant for the same or a different pesticide use. The pesticidal compound and the synergistic composition can generally be mixed together in a weight ratio of 1:100 to 100:1.
    [0031] The present invention includes within its scope methods for the control or prevention of physiological attacks and methods for providing improved plant physiology, wherein the improved plant physiology is characterized by means of at least one of the effects selected from from the group consisting of improved root growth, better water use and efficiency, greater nitrogen use efficiency, delayed senescence, and increased yield. These methods comprise applying to the locus of the fungus, or to a locus at which infestation is to be prevented (for example, by applying to wheat or barley plants), a fungicidally effective amount of the synergistic composition. The synergistic composition is suitable for the treatment of various plants at fungicidal levels, while having low phytotoxicity. The synergistic composition is useful in a protective or eradicating way. The synergistic composition is applied by any of a variety of known techniques, either as the synergistic composition or as a formulation comprising the synergistic composition. For example, the synergistic compositions can be applied to the roots, seeds or foliage of plants to control various fungi without damaging the commercial value of the plants. The synergistic composition is applied in the form of any of the types of formulation generally used, for example, in the form of solutions, powders, wet powders, fluid concentrates or emulsifiable concentrates. These materials are conveniently applied in a number of known ways.
    [0032] The synergistic composition has been found to have a significant fungicidal effect, particularly for agricultural use. Additionally, the synergistic composition has been found to promote improved plant physiology, wherein the improved plant physiology is characterized by means of an improved green state and an improved yield. The synergistic composition is particularly effective for use with agricultural crops and horticultural plants, or with wood, paint, leather or carpet backing.
    [0033] In particular, the synergistic composition is effective in controlling a variety of undesirable fungi that infect crops of useful plants. The synergistic composition can be used against a variety of Ascomycete and Basidiomycete fungi, including, for example, the following representative fungal species: wheat brown rust (Puccinia recondita, PUCCRT); Wheat rust (Puccinia striiformis, PUCCST); Wheat leaf spot (Mycosphaerella graminicola, anamorph: Septoria tritici, SEPTTR); Wheat glume stain (Leptosphaeria nodorum, Bayer code LEPTNO, anamorph: Stagonospora nodorum); Barley leaf spot (Rhynchosporium sealis, RHYNSE), barley gluma spot (Cochliobolus sativum, COCHSA, anamorph: Helminthosporium sativum); Leaf spot of sugar beet (Cercospora beticola, CERCBE); Peanut leaf spot (Mycosphaerella arachidis, MYCOAR, anamorph: Cercospora arachidicola); Cucumber anthracnose (Glomerella lagenarium, anamorph: Colletotrichum lagenarium, COLLLA). It will be understood by those skilled in the art that the effectiveness of the synergistic compositions for one or more of the above fungi establishes the general utility of the synergistic compositions as fungicides.
    [0034] The synergistic compositions have a large proportion of effectiveness as a fungicide. The exact amount of the synergistic composition to be applied depends not only on the relative amounts of the components, but also on the particular action desired, the fungal species to be controlled and its growth phase, as well as the part of the plant or other product to be contacted. with the synergistic composition. Thus, formulations containing the synergistic composition may not be equally effective at similar concentrations or against the same fungal species.
    The synergistic compositions are effective in use with plants in a disease-inhibiting and phytologically acceptable amount. The term "disease inhibiting amount and phytologically acceptable amount" refers to an amount of the synergistic composition that kills or inhibits the disease of the plant for which control is desired, but is not significantly toxic to the plant. The exact concentration of synergistic composition required varies with the fungal disease to be controlled, the type of formulation employed, the method of application, the particular plant species, climatic conditions, and the like.
    [0036] The present compositions can be applied to fungi or their locus by using conventional soil sprays, granule applicators and by other conventional means known to those skilled in the art.
    [0037] The following examples are provided to further illustrate the description. They are not intended to be construed as limiting the present invention. barley leaf spot (Rhynchosporium sealis: RHYNSE):
    [0038] The results in Tables 1 to 3 were generated using foliar applications applied in research experiments of small plots (2.5 x 8.0 meters (m)) to evaluate the compositions in winter barley (Hordeum vulgare, HORVW) . Two treatments were applied at BBCH culture stages 31 and 43 to 49, respectively. Applications were made using a backpack sprayer (250kPa) equipped with a 2.5 m spray boom equipped with 5 flat Agrotop-AMl 1002 vent nozzles spaced at 50 centimeters (cm) oriented at 90 degrees. The output volume of the compositions, diluted in water, was 200 liters per hectare (L / ha). Visual evaluations for the control of barley leaf spot (Rhynchosporium sealis, RHYNSE) were reported as the percentage (%) of infected leaf area and were conducted at the time of application 1 (untreated control in BBCH 31), at the time of application 2 (BBCH 43-49) and 2 to 4 weeks after application 2. The phytosanitary status was improved by visual assessment of % green leaf area 6 weeks after application 2 at the BBCH 75-77 growth stage. Reported values are means from 4 replicates and statistical differences were determined using Duncan's Nova MRT (P = 0.5).
    [0039] The Colby equation was used to determine the expected fungicidal effects of the mixtures. (See Colby, S.R. Calculation of synergistic and antagonistic response of herbicide combinations. Weeds 1967, 15, 20 to 22).
    [0040] The following equation was used to calculate the expected activity of mixtures containing two active ingredients, A and B: Expected = A + B-(A x B / 100) A = observed effectiveness of active component A at the same concentration used in the mixture;B = observed efficacy of active component B at the same concentration used in the mixture.
    [0041] The ability of the compositions in the present invention described to provide adequate disease control is illustrated by the efficacy data in Table 1 and representative synergistic interactions of the compositions with respect to increased yield and improved plant health are shown in the Tables 2 to 3, respectively. Table 1. Biological Activity Observed with Synergistic Mixtures of Compounds of Formula I and Prothioconazole in Applications in Winter Barley (Hordeum vulgare, HORVW) to Control Barley Leaf Spot (Rhynchosporium secalis; RHYNSE)
    * g ai/h = grams of active ingredient / hectare* % visible lesions = (visible lesions in untreated lesions - visible lesions in treatment) / visible lesions in untreated lesions x 100.Table 2. Yield improvement observed with the synergistic blends of formula I compounds and prothioconazole in winter barley (Hordeum vulgare, HORVW) applications to control barley leaf spot (Rhynchosporium sealis, RHYNSE).
    * g ai / h = grams of active ingredient / hectare.* % Increase in Treated Yield Ratio: Untreated* = (Observed Yield / Untreated Yield) x 100-100.* Synergy Factor = % Increased Observed Yield/% Expected Yield Increase.* Observed gross yield data are measured in metric tons/hectare (t/ha). Table 3. Plant Environmentalization Improvements Observed with Synergistic Mixtures of Compounds of Formula I and Prothioconazole in Applications in Winter Barley (Hordeum vulgare, HORVW) to control Barley Leaf Spot (Rhynchosporium secalis) RHYNSE).

    * g ai / h = grams of active ingredient / hectare.* % increase in % of treated green leaf ratio: untreated = (% observed green leaf / % untreated green leaf) x 100-100.* Synergy Factor = % observed green leaf / % expected green leaf.
    权利要求:
    Claims (10)
    [0001]
    1. Synergistic mixture, characterized in that it comprises a fungicidally effective amount of: (a) a compound of Formula I,
    [0002]
    2. Synergistic composition to provide improved growth in crops, characterized in that it comprises: a mixture, as defined in claim 1, and a phytologically acceptable carrier material, the improved growth in crops being distinguished by at least one of the selected effects of the group consisting of preventing or curing pathogenic fungi and improving plant physiology, in which improved plant physiology is distinguished by at least one of the effects selected from the group consisting of improved root growth, improved greening, use and improved water efficiency, improved nitrogen use efficiency, delayed senescence, and improved yield.
    [0003]
    3. Composition according to claim 2, characterized in that the improved growth is distinguished by curing or preventing a disease caused by pathogenic fungi.
    [0004]
    4. Composition, according to claim 3, characterized in that the disease and pathogenic fungi are selected from the group consisting of barley leaf spot (Rhynchosporium sealis, RHYNSE) and barley gluma spot (Co - chliobolus sativum, COCHSA, anamorph: Helminthosporium sativum).
    [0005]
    5. Composition, according to claim 4, characterized in that the pathogen is Rhynchosporium secalis (RHYN-SE), the causal agent of barley leaf spot.
    [0006]
    6. Composition according to claim 2, characterized in that the improved growth is distinguished by an improved plant physiology, distinguished by the fact that the improved plant physiology is distinguished by at least one of the effects selected from the group that it consists of improved root growth, improved greening, improved water use and use efficiency, improved nitrogen use efficiency, delayed senescence, and increased yield.
    [0007]
    7. Composition according to claim 6, characterized in that the improved plant physiology is distinguished by means of an increased yield.
    [0008]
    8. Composition according to claim 6, characterized in that the improved plant physiology is distinguished through an increase in the greening of plant tissue.
    [0009]
    9. A method for improving crop growth, characterized in that it comprises applying a fungicidally effective amount of a synergistic mixture as defined in claim 1, said effective amount being applied to at least one plant, an area adjacent to a plant, soil adapted to support the growth of a plant, a root of a plant and foliage of a plant, said synergistic mixture being effective against at least one disease selected from the group consisting of barley leaf spot and leaf spot barley glume.
    [0010]
    10. Method according to claim 9, characterized in that the at least one disease is caused by fungal pathogens, and the fungal pathogens are Rhynchosporium secalis.
    类似技术:
    公开号 | 公开日 | 专利标题
    ES2744911T3|2020-02-26|Synergistic fungicide mixtures to fight against fungi in cereals
    BR112017000066B1|2021-06-22|SYNERGIC MIXTURE AND COMPOSITION, AND METHOD TO ENHANCE IMPROVED GROWTH IN CROPS
    AU2013370491B2|2016-10-06|Synergistic fungicidal mixtures for fungal control in cereals
    TWI640248B|2018-11-11|Synergistic fungicidal compositions
    DK2485592T3|2016-09-05|Synergistic fungicidal compounds for mushrooms fight in cereals
    JP5655080B2|2015-01-14|Synergistic fungicidal composition containing 5-fluorocytosine for controlling fungi in cereals
    BR112019010109A2|2019-08-20|fungicide compounds and mixtures for fungal control in cereals
    BR112019010138A2|2019-08-20|fungicidal compounds and mixtures for fungal control in cereals
    TW201842851A|2018-12-16|Synergistic mixtures for fungal control in cereals
    BR112019010147A2|2019-09-17|fungicidal compounds and mixtures for fungal control in cereals
    TW201230958A|2012-08-01|Synergistic fungicidal interactions of 5-fluorocytosine and other fungicides
    JP6407166B2|2018-10-17|Fungicidal composition for controlling sugar beet brown spot
    AU2016381080B2|2020-07-30|Synergistic fungicidal mixtures for fungal control of rice blast
    CA2821391A1|2012-06-21|Synergistic fungicidal interactions of aminopyrimidines and other fungicides
    同族专利:
    公开号 | 公开日
    US20160037774A1|2016-02-11|
    RU2690448C2|2019-06-03|
    RU2017100033A3|2018-12-17|
    WO2016023013A2|2016-02-11|
    BR112017000066A2|2017-11-14|
    NZ727614A|2018-05-25|
    KR20170039119A|2017-04-10|
    WO2016023013A3|2016-05-12|
    EP3177145A2|2017-06-14|
    CN106488703A|2017-03-08|
    MX2016017091A|2017-05-10|
    EP3177145A4|2017-12-20|
    CA2954415A1|2016-02-11|
    AU2015300781A1|2017-01-12|
    CO2017000046A2|2017-07-11|
    IL249912D0|2017-03-30|
    RU2017100033A|2018-09-10|
    JP2017529317A|2017-10-05|
    ZA201700065B|2019-06-26|
    JP6782223B2|2020-11-11|
    UA120853C2|2020-02-25|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    NZ625074A|2009-10-07|2015-11-27|Dow Agrosciences Llc|Synergistic fungicidal mixtures for fungal control in cereals|
    ES2666144T3|2012-12-28|2018-05-03|Dow Agrosciences Llc|Synergistic fungicidal mixtures for fungal control in cereals|
    US9750248B2|2012-12-31|2017-09-05|Dow Agrosciences Llc|Synergistic fungicidal compositions|
    JP6539205B2|2013-07-10|2019-07-03|Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社|Composition for controlling synergistic plant diseases comprising picolinic acid derivative|
    CN106061259B|2013-12-31|2019-08-16|美国陶氏益农公司|Synergistic fungicidal mixture for fungus control in cereal|
    EP3141118A1|2015-09-14|2017-03-15|Bayer CropScience AG|Compound combination for controlling control phytopathogenic harmful fungi|US10173971B2|2014-12-30|2019-01-08|Dow Agrosciences Llc|Picolinamides with fungicidal activity|
    NZ732573A|2014-12-30|2019-01-25|Dow Agrosciences Llc|Use of picolinamide compounds with fungicidal activity|
    MX2017008441A|2014-12-30|2018-04-20|Dow Agrosciences Llc|Use of picolinamide compounds with fungicidal activity.|
    MX2017008442A|2014-12-30|2017-10-02|Dow Agrosciences Llc|Use of picolinamides as fungicides.|
    EP3808181A1|2014-12-30|2021-04-21|Dow AgroSciences LLC|Use of picolinamide compounds as fungicides|
    BR112018013434A2|2015-12-30|2018-12-04|Dow Agrosciences Llc|fungal control of white mold|
    EP3245872A1|2016-05-20|2017-11-22|BASF Agro B.V.|Pesticidal compositions|
    US10173982B2|2016-08-30|2019-01-08|Dow Agrosciences Llc|Picolinamides as fungicides|
    US10111432B2|2016-08-30|2018-10-30|Dow Agrosciences Llc|Picolinamide N-oxide compounds with fungicidal activity|
    WO2018044987A1|2016-08-30|2018-03-08|Dow Agrosciences Llc|Thiopicolinamide compounds with fungicidal activity|
    US10034477B2|2016-08-30|2018-07-31|Dow Agrosciences Llc|Pyrido-1,3-oxazine-2,4-dione compounds with fungicidal activity|
    AR110207A1|2016-11-22|2019-03-06|Viamet Pharmaceuticals Inc|COMPOUNDS AND MIXTURES FUNGICIDES FOR THE CONTROL OF FUNGES IN CEREALS|
    BR102018000132A2|2017-01-05|2018-08-14|Dow Agrosciences Llc|picolinamides as fungicides|
    TW201842851A|2017-05-02|2018-12-16|美商陶氏農業科學公司|Synergistic mixtures for fungal control in cereals|
    CA3062074A1|2017-05-02|2018-11-08|Dow Agrosciences Llc|Use of an acyclic picolinamide compound as a fungicide for fungal diseases on turfgrasses|
    GR1009508B|2017-07-24|2019-04-19|Δημητριος Στεφανου Μπραντζος|Method for image transfer between two vehicles-arrangement and application of same|
    BR102019004480A2|2018-03-08|2019-10-01|Dow Agrosciences Llc|PICOLINAMIDES AS FUNGICIDES|
    法律状态:
    2019-08-27| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2021-03-09| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-06-22| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/08/2015, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US201462035198P| true| 2014-08-08|2014-08-08|
    US62/035,198|2014-08-08|
    PCT/US2015/044383|WO2016023013A2|2014-08-08|2015-08-08|Synergistic fungicidal mixtures for fungal control in cereals|
    [返回顶部]