• 专利附录
  • 专利说明
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    • 专利摘要:
    oral care composition containing sources of zinc, tin and fluoride ions and use of such sources for the preparation of an oral care composition an oral care composition containing a source of tin ions, a source of fluoride ions and a insoluble source of zinc ions, such as zinc oxide. the composition contains enough citric acid to increase the level of soluble zinc ions.
    公开号:BR112016028403B1
    申请号:R112016028403-8
    申请日:2014-06-20
    公开日:2020-12-15
    发明作者:Kavita VEMISHETTI；Michael Prencipe；Linh Fruge
    申请人:Colgate-Palmolive Company；
    IPC主号:
    专利说明:

    BACKGROUND
    [001] There is a need for agents in oral care products that provide improved benefits, including antibacterials, anti-caries, enamel erosion prevention, breath fresheners and the like. The antibacterial effects of zinc ions, tin ions and / or fluoride ions in the oral cavity are described in the art and numerous attempts have been made to prepare dentifrice compositions incorporating zinc ions, tin ions and / or fluoride ions to remove advantage of therapeutic benefits such as plaque, gum inflammation, reduced gingivitis, and the like. In particular, soluble zinc salts, such as zinc citrate, have been used in toothpaste compositions.
    [002] Sources of insoluble zinc ions, such as zinc oxide, have also been disclosed for use in toothpastes, see, for example, US Patent Application Publication 2012/0207686 ("publication 686"). However, the use of insoluble zinc salts is often limited by the low levels of zinc ions available for distribution on the surfaces of teeth and by the unwanted consumer astringency when higher levels of zinc are used.
    [003] It would be desirable to provide a composition for oral care that has an even greater effectiveness than the compositions previously known for its prevention and / or reduction of biofilm, plaque, and similar oral inflammation. BRIEF SUMMARY
    [004] The present invention relates to an oral care composition, for example a toothpaste composition, which can effectively combine a source of tin ions, a source of fluoride ions and an insoluble source of zinc ions in a system with low water content, preferably single-phase, which has an efficient distribution of ions to the oral cavity. Tin and zinc ions have been found to help reduce / prevent oral inflammation, such as gingivitis and periodontitis, plaque formation, oral biofilm formation, tooth sensitivity and improved breath benefits.
    [005] The present invention relates to an oral care composition comprising: (a) an orally acceptable vehicle; (b) a source of fluoride ions; (c) a source of tin ions; (d) an insoluble source of zinc ions; (e) a buffer system comprising citric acid, wherein the amount of citric acid is at least 1% by weight of the composition, and where the composition has a total water content of less than 15% by weight.
    [006] In another aspect, the modalities described herein provide a method for treating and preventing the accumulation of bacterial plaques comprising administering the toothpaste composition described above to the oral cavity.
    [007] It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for illustrative purposes only and are not intended to limit the scope of the invention. DETAILED DESCRIPTION
    [008] As used throughout this document, ranges are used as abbreviations to describe each and every value that is within the range. Any value within the range can be selected as the end of the range. In addition, all references cited herein are hereby incorporated by reference in their entirety. In the event of a conflict between a definition in this description and a cited reference, the present disclosure prevails.
    [009] Unless otherwise specified, all percentages and quantities expressed here and elsewhere in the specification should be understood as referring to weight percentages. The quantities given are based on the active weight of the material.
    [0010] In this description, unless otherwise stated, the use of the singular also includes the plural. For example, "a source of tin ions" also comprises the case where more than one source of tin ions is used.
    [0011] As used herein, the words "preferred" and "preferred" refer to modalities of the invention that provide certain benefits, under certain circumstances. However, other modalities may also be preferred, under the same or other circumstances. In addition, the recitation of one or more preferred modalities does not imply that other modalities are not useful and does not exclude other modalities from the scope of the invention. Source of Insoluble Zinc Ions
    [0012] The insoluble source of zinc ions in one embodiment is an insoluble zinc ion salt. As used herein, the term "insoluble" means that the material or compound has a solubility of less than 0.1% by weight (based on the weight of the composition) in an aqueous solution at 25 ° C at pH 7. It will also be understood that at lower or higher pH, insoluble zinc ion sources can become significantly more soluble. Examples of suitable insoluble zinc ion sources include zinc oxide, zinc phosphate, zinc pyrophosphate and other zinc compounds. of zinc ions is preferably zinc oxide.
    [0013] In general, the higher the level of solubilized zinc ions available for distribution on oral surfaces, the greater the level of effectiveness. The present invention provides high levels of zinc ions present in the composition from the insoluble source of zinc ions. Typically, a composition of the invention has more than 50% soluble zinc ions (for example, for a composition with 1% by weight (1.0) of an insoluble source of zinc ions, the amount of zinc will be greater than 0 , 5% (0.5) after aging for 13 weeks at 40 ° C), in other modalities, more than 60%, more than 70% or more than 80%, after aging for 13 weeks at 40 ° C.
    [0014] The amount of zinc ion source will typically be present in an amount of 0.1% to 2% by weight, by weight of the final composition. In one embodiment, the source of zinc ions is present in an amount of 0.5 to 1.5%, or 0.9% to 1.1%. Tin Ion Source
    [0015] The compositions of the present invention comprise a source of tin ions. The source of tin ions can be a soluble or insoluble tin compound with inorganic or organic counterions. Examples include fluoride, chloride, chlorofluoride, acetate, hexafluorozirconate, sulfate, tartrate, gluconate, citrate, malate, glycinate, pyrophosphate, metaphosphate, oxalate, phosphate, carbonate and tin oxide salts.
    [0016] Oral compositions containing tin salts, particularly tin fluoride and tin chloride, are described in U.S. Patent No. 5,004,597. Further descriptions of tin salt-based toothpastes are found in US patent no. 5,578,293. Preferred tin salts are tin fluoride and tin chloride dihydrate. Other examples of tin salts include tin acetate, tin tartrate and tin and sodium citrate.
    [0017] In general, the higher the level of solubilized tin ions available for distribution on oral surfaces, the greater the level of effectiveness. The present invention provides high levels of tin ions present in the composition from the insoluble source of zinc ions. Typically, a composition of the invention has more than 50% soluble tin ions, in other embodiments, more than 60%, more than 70%, more than 80% or more than 90% after aging for 13 weeks at 40 ° C.
    [0018] The tin ion source will typically be present in an amount of 0.05% to 5%, by weight of the final composition. In one embodiment, the source of tin ions is present in an amount of 0.1 to 1%, or 0.35% to 0.55%.
    [0019] Tin and zinc ions are derived from the ion source (s) found in the oral care composition in an effective amount. An effective amount is defined from at least 1000 ppm of metal ions (zinc plus tin), preferably 2,000 ppm to 15,000 ppm. Most preferably, metal ions are present in an amount of 3,000 ppm to 13,000 ppm and even more preferably from 4,000 ppm to 10,000 ppm. This is the total amount of metal ions (tin and zinc) that is present in the compositions for distribution to the tooth surface.
    [0020] The combined metal ion sources (tin and zinc) will typically be present in an amount of 0.15% to 7%, by weight of the final composition. Preferably, the metal ion sources are present in an amount of 0.6 to 2.5%, more preferably, from 1.25% to 1.65%. Fluoride Ion Source
    [0021] The fluoride ion source here is a fluoride source capable of providing free fluoride ions. Soluble fluoride ion sources include sodium fluoride, tin fluoride, indium fluoride, zinc fluoride and sodium monofluorophosphate . Sodium fluoride and tin fluoride are the preferred sources of soluble fluoride ions. US Patent No. 2,947,725 and US Patent No. 3,678,154, describe such sources of fluoride ions as well as others.
    [0022] The source of fluoride ions in the present compositions is preferably present as a solid dispersion in the composition during storage, prior to use in the actual brushing of the composition by a consumer. The water level in the present compositions is too low to allow the fluoride source to dissolve in the composition during storage. In this way, the interaction between fluoride ions and other ingredients such as polyphosphate, or silica, if present, is minimized during storage, providing a stable composition during storage. When the composition comes in contact with saliva and / or water at the time of brushing, the fluoride source will preferably be dispersed and the active ion will be released into the oral cavity.
    [0023] The present compositions may contain a source of soluble fluoride ions capable of supplying from 50 ppm to 3500 ppm, and preferably from 500 ppm to 3000 ppm of free fluoride ions. To provide the desired amount of fluoride ions, the source of fluoride ions can be present in the composition for total oral care in an amount of 0.1% to 5%, in an embodiment, from 0.2% to 1% and even from 0.3 to 0.6% by weight of the total composition. Buffer System
    [0024] The compositions described herein also contain a buffer system comprising citric acid. It was surprisingly found that an amount of citric acid greater than 0.6% by weight of the oral care composition will result, substantially, in more zinc ions and / or tin ions present in the composition, from the respective sources of zinc and / or tin in the composition, when aged at 40 ° C for 8 or 13 weeks. In some embodiments, the amount of citric acid is 0.5 to 4% by weight or 1 to 3% by weight, or 1.1 to 1.5% by weight or 1.8 to 2.2% by weight or 1 , 3% or 2% by weight of the oral care composition. In one embodiment, the buffer system comprises citric acid and sodium citrate, in particular, trisodium citrate. Buffering agents, as used herein, refer to agents that can be used to adjust the pH of the compositions to a range of pH 3.0 to pH 10, more typically 6 to 8.
    [0025] In addition to citric acid, other buffering agents that may optionally be present include alkali metal hydroxides, ammonium hydroxide, organic ammonium compounds, carbonates, sesquicarbonates, borates, silicates, phosphates, imidazole and mixtures thereof. Specific buffering agents include monosodium phosphate, trisodium phosphate, sodium benzoate, benzoic acid, sodium hydroxide, potassium hydroxide, alkali metal carbonate salts, sodium carbonate, imidazole and pyrophosphate. The total amounts of buffering agents are typically 0.1% to 30%, or 0.1% to 10%, or 0.3% to 3%, by weight of the present composition. Total Water Content
    [0026] The water used in the preparation of commercially suitable oral compositions should preferably be low in ions and free from organic impurities. In the toothpaste composition, water will generally comprise less than 20% by weight, or less than 15% by weight, or less than 15% by more than 10% by weight, by weight of the composition presented herein. The amounts of water include free water that is added plus that introduced with other materials, such as silica, surfactant solutions and / or dye solutions. Orally Acceptable Carrier
    [0027] In certain embodiments, the present invention provides compositions comprising an orally acceptable vehicle or carrier. As used herein, an "orally acceptable carrier" and "orally acceptable carrier" are used interchangeably and refer to a material or combination of materials that is safe for use in the present compositions, proportional to a reasonable benefit / risk ratio, with which the other ingredients can be combined with while retaining significant clinical efficacy. Such carrier materials must be selected for compatibility with the other ingredients in the compositions and preferably do not substantially reduce the effectiveness of the other ingredients. The selection of specific carrier components depends on the desired product form, including toothpastes, rinses, gels and paints.
    [0028] Materials useful in carriers include, but are not limited to: adhesives, thickening agents, viscosity modifiers, thinners, surfactants, anti-calculating agents, abrasives, foam modulators, bleaching agents such as peroxides, peroxide activators , peroxide stability agents, pH modifying agents, humectants, mouthfeel agents, sweeteners, flavorings, dyes and combinations thereof. Adherence agents
    [0029] As used here, an "adhesion agent" is a material or combination of materials that enhances the retention of an ingredient on a surface of the oral cavity on which it is applied. Such adhesion agents include, without limitation: adhesives, film-forming materials and viscosity enhancers; for example, hydrophilic organic polymers, hydrophobic organic polymers, silicone gums, silicone adhesives, silicas and combinations thereof. In one embodiment, the adhesive agent is a methyl vinyl ether / maleic anhydride copolymer having an average molecular weight (MW) of 30,000 to 1,000,000, for example, 300,000 to 800,000. The preparation of the polymethyl vinyl ether-maleic anhydride copolymer is specifically set out in US Patents 5,047,490 and 4,627,977. The polymethyl vinyl ether maleic anhydride copolymer is also commercially available under the trade name Gantrez® AN from ISP (Ashland), Wayne, N.J. Thickeners
    [0030] The dentifrice compositions of the present invention can incorporate one or more thickening agents that can act as a binder system. The total amount of thickening agent is typically 0% to 3% by weight, or 0.1% to 1.5% by weight, or 0.2% to 0.5% by weight, by weight of the composition for oral care.
    [0031] One such thickening agent is polyvinylpyrrolidone (PVP), in particular cross-linked PVP, optionally in combination with a gum such as xanthan gum. Other thickening agents include polysaccharides, carbomers, poloxamers, modified celluloses, for example, carboxymethyl cellulose (CMC) and mixtures thereof. In some embodiments, these thickening agents provide desirable consistency and gelation to the low water content oral care composition. It is previously known that gelling materials that provide desirable rheology with water and humectant provide rheology generally less satisfactory when water is not present to activate its gelling binding properties. This is believed to be especially true for the glycerin humectant. The thickening agent can also comprise additional inorganic thickening agents.
    [0032] Polysaccharides, including gums, which are suitable for use here as thickening agents include carrageenans, gellan gum, locust bean gum, xanthan gum and mixtures thereof. Carageenan is a polysaccharide derived from seaweed and has been known for its use as a binder or thickener in toothpaste, see, for example, US Patent 6,187,293 B1 and 6,162,418. There are several types of carrageenans that can be distinguished by their source of seaweed and / or by their degree and position of sulfation. Kappa carrages, modified kappa carrages, iota carrages, modified iota carrages and mixtures thereof are suitable for use in the present invention. Carragens suitable for use here include those commercially available from FMC Company under the "Viscarin" series designation, including, but not limited to, Viscarin TP 329, Viscarin TP 388 and Viscarin TP 389.
    [0033] Gellan gum is another polysaccharide that is suitable for use here. It is a polysaccharide fermented aerobically by Pseudomonas elodea. It can also form a matrix with a low acceptable water content when it is present at a level of 0.1% to 3%, preferably from 0.4% to 1.8% (w / w).
    [0034] Locust bean gum and xanthan gum are also polysaccharides suitable for use here. Locust bean gum or xanthan gum as thickening agents can form a stable and acceptable toothpaste matrix when the water level is less than 10% in the composition.
    [0035] Poloxamers are also suitable as thickening agents in the present invention. Poloxamer is a synthetic block copolymer of ethylene oxide and propylene oxide. It is available in several types. Here, poloxamer 407 is preferred. It can be partially dissolved in water. When the temperature is higher than 65 ° C, it can dissolve in glycerin. POLOXAMER 407® is available, for example, together BASF CORPORATION, New Jersey, USA.
    [0036] Carbomers are also suitable as thickening agents in a low water matrix, especially in a non-aqueous matrix.
    [0037] The modified celluloses such as hydroxyethyl cellulose and CMC are also good thickening agents in the matrix with low water content. Since the water level is limited in the present compositions, hydroxyethyl cellulose modified with a hydrophobic chain (C12-C20) is preferred to increase the solubility and hydration of this thickener in other lower polar solvents, such as glycerin, propylene glycol and polyethylene glycol (PEG).
    [0038] The thickening agent can comprise inorganic thickening agents, such as colloidal magnesium aluminum silicate or finely divided silica to further improve the texture. Additional inorganic thickening agents, if present, can be used in an amount of 0.1% to 15%, more preferably, 0.1% to 5%, by weight of the oral care composition. Humectant
    [0039] The humectant serves to prevent the toothpaste compositions from hardening after exposure to air and certain humectants can also impart desirable sweetness to the flavor of the toothpaste compositions. Humectants suitable for use in the invention include glycerin, sorbitol, polyethylene glycol, propylene glycol, xylitol, and other edible polyhydric alcohols. Glycerin, polyethylene glycol, polypropylene glycol and mixtures thereof are preferred, especially mixtures thereof. The humectant generally comprises from 0.1% to 70%, preferably from 1% to 60%, and more preferably, from 15% to 55%, by weight of the composition.
    [0040] The humectant is believed to have a significant impact on the matrix viscosity with low water content. For example, when using polysaccharide as a thickening agent in the composition, the viscosity of the matrix increases when the level of glycerin or polyethylene glycol increases. On the contrary, the viscosity of the matrix will decrease when the level of propylene glycol increases in the composition. Anti-calculating agents
    [0041] In various embodiments of the present invention, the oral care composition may comprise an anti-calculating agent (tartar control). Generally, tartar control agents are classified as being incompatible with some bleaching agents, but embodiments of the present invention incorporate tartar control agents and bleaching agents, in a single phase bleaching composition. Suitable anti-calculating agents include, without limitation, phosphates and polyphosphates (eg, pyrophosphates and tripolyphosphates), polyaminopropane sulfonic acid (AMPS), hexametaphosphate salts, zinc citrate trihydrate, polypeptides (such as polyaspartic and polyglutamic acids), polyolefin sulfonates, polyolefin phosphates, and diphosphonates (for example, EHDP, AHP). The oral composition may include a mixture of different anti-calculating agents. In a preferred embodiment, tetrasodium pyrophosphate (TSPP), sodium tripolyphosphate (STPP), tetrapotassium pyrophosphate (TKPP), or mixtures thereof are used. Anti-calculating agents can comprise 0.1% to 30%, or 0.1% to 15%, or 1% to 10%, or 2% to 6%, by weight. Abrasives
    [0042] An abrasive polishing material can also be included in toothpaste compositions. The abrasive polishing material contemplated for use in the compositions of the present invention can be any material that does not excessively abrasion the dentin. Typical abrasive polishing materials include silicas including gels and precipitates; aluminum; phosphates including orthophosphates, polymetaphosphates and pyrophosphates; and mixtures thereof. Specific examples include dicalcium orthophosphate dihydrate, calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate, insoluble sodium polymetaphosphate, hydrated alumina, calcium beta pyrophosphate, calcium carbonate, and resinous abrasive materials such as particulate condensate and formaldehyde condensate products. , and others such as those described in US Patent No. 3,070,510. Abrasive mixtures can also be used. If the toothpaste or particular phase composition comprises a polyphosphate having an average chain length of 4 or more, abrasives containing calcium and alumina are not preferred abrasives. The most preferred abrasive is silica.
    [0043] Silica dental abrasives of various types are preferred due to their exclusive benefits of exceptional dental cleaning and polishing without unduly damaging the enamel or dentin of the tooth. The silica abrasive polishing materials of the present invention, as well as other abrasives, generally have an average particle size ranging between 0.1 to 30 microns and preferably between 5 and 15 microns. The abrasive may be precipitated silica or silica gels such as the silica xerogels described in U.S. Patent No. 3,538,230, and US Patent No. 3,862,307. Silica xerogels sold under the trade name "SYLOID®" with W.R. Grace & Company, Davison Chemical Division. Also preferred are precipitated silica materials such as those marketed by J.M. Huber Corporation under the trade name "ZEODENT®", particularly the silica bearing the designation "Zeodent 119". The types of silica dental abrasives useful in the toothpastes of the present invention are described in more detail in U.S. Patent no. 4,340,583. Silica abrasives are also described in U.S. Patent Nos. 5,58,160; 5,603,920; 5,651,958; 5,658,553; and 5,716,601. The abrasive in the oral care compositions described herein is generally present at a level of 6% to 70% by weight of the composition. Preferably, toothpastes contain 10% to 50% abrasive, by weight of the composition. Peroxide source
    [0044] The present invention can include a source of peroxide in the composition. The peroxide source is selected from the group consisting of hydrogen peroxide, calcium peroxide, urea peroxide and mixtures thereof. The preferred source of peroxide is calcium peroxide. The following amounts represent the amount of peroxide raw material, although the peroxide source may contain ingredients other than the peroxide raw material. The present composition may contain from 0.01% to 10%, preferably from 0.1% to 5%, more preferably, from 0.2% to 3% and, more preferably, from 0.3% to 0.8% of a peroxide source, by weight of the toothpaste composition. Alkali Metal Baking Salt
    [0045] The compositions can also include an alkali metal bicarbonate salt. Alkali metal bicarbonate salts are water soluble and, unless stabilized, tend to release carbon dioxide in an aqueous system. Baking soda, also known as baking soda, is the preferred alkali metal bicarbonate salt. The alkali metal bicarbonate salt also functions as a buffering agent. The present composition may contain from 0.5% to 50%, preferably from 0.5% to 30%, more preferably from 2% to 20%, and more preferably, from 5% to 18% of a alkali metal bicarbonate salt, by weight of the toothpaste composition. Surfactants
    [0046] The compositions can also comprise surfactants, also commonly known as foaming agents. Suitable surfactants are those that are reasonably stable and foam over a wide pH range. The surfactant can be anionic, non-ionic, amphoteric, zwitterionic, cationic, or mixtures thereof. Anionic surfactants useful here include the water-soluble salts of alkyl sulfates with 8 to 20 carbon atoms in the alkyl radical (e.g., sodium alkyl sulfate) and the water-soluble salts of sulfonated monoglycerides of fatty acids with 8 to 20 carbon atoms. Sodium lauryl sulfate and coconut and sodium monoglyceride sulfonates are examples of anionic surfactants of this type. Other suitable anionic surfactants are sarcosinates, such as sodium lauroyl sarcosinate, taurates, sodium lauryl sulfoacetate, sodium lauroyl isethionate, sodium lauret carboxylate and sodium dodecyl benzenesulfonate. Mixtures of anionic surfactants can also be used. Many suitable anionic surfactants are disclosed in US Patent No. 3,959,458.
    [0047] Nonionic surfactants that can be used in the compositions can be broadly defined as compounds produced by the condensation of alkylene oxide groups (of hydrophilic nature) with a hydrophobic organic compound that can be aliphatic or alkyl aromatic in nature. Examples of suitable nonionic surfactants include poloxamers (sold under the trade name PLURONIC®), polyoxyethylene, polyoxyethylene sorbitan esters (sold under the trade name TWEENS®), polyoxyl 40 hydrogenated castor oil, fatty alcohol ethoxylates, oxide condensates of polyethylene of alkyl phenols, products derived from the condensation of ethylene oxide with the reaction product of propylene oxide and ethylene diamine, ethylene oxide condensates of aliphatic alcohols, long-chain tertiary amine oxides, tertiary phosphine oxides of chain long chain dialkyl sulfoxides and mixtures of such materials. Amphoteric surfactants useful in the present invention can be widely described as derivatives of aliphatic secondary and tertiary amines in which the aliphatic radical can be straight or branched chain, and where one of the aliphatic substituents contains 8 to 18 carbon atoms and one contains an anionic group solubilizing in water, for example, carboxylate, sulfonate, sulfate, phosphate or phosphonate. Other suitable amphoteric surfactants are betaines, specifically cocamidopropyl betaine. Mixtures of amphoteric surfactants can also be used. Many of these suitable nonionic and amphoteric surfactants are disclosed in US Patent No. 4,051,234. The present composition typically comprises one or more surfactants, each at a level of 0.25% to 12%, preferably from 0.5% to 8%, and most preferably, from 1% to 6%, by weight composition.
    [0048] In one embodiment, the oral care composition includes a surfactant system comprising sodium lauryl sulfate (SLS), cocamidopropyl betaine, or a mixture thereof. Antimicrobial Agents
    [0049] The present compositions can also include antimicrobial agents. Included among these agents are water-insoluble non-cationic antimicrobial agents such as halogenated diphenyl ethers, phenolic compounds including phenol and their counterparts, aromatic halo and mono-polyalkyl, resorcinol and its derivatives, bisphenolic compounds and halogenated salicylanilides, benzoic esters and carbanylides halogenated, polyphenols and herbs. Water-soluble antimicrobials include quaternary ammonium salts and bis-bikanide salts, among others. Triclosan monophosphate is an additional preferred water-soluble antimicrobial agent. Quaternary ammonium agents include those in which one or two of the substituents on the quaternary nitrogen have a carbon chain length (typically alkyl group) of 8 to 20, typically 10 to 18 carbon atoms, while the remaining substitutes (typically alkyl or benzyl group) have a lower number of carbon atoms, such as 1 to 7 carbon atoms, typically methyl or ethyl groups. Dodecyl trimethyl ammonium bromide, tetradecyl pyridinium chloride, domifen bromide, N-tetradecyl-4-ethyl pyridinium chloride, dodecyl dimethyl (2-phenoxyethyl) ammonium, benzyl dimethyl stearyl ammonium chloride, cetyl chloride , 5-amino-1,3-bis (2-ethylhexyl) -5-methylhexhydropyrimidine, benzalkonium chloride, benzethonium chloride and methyl benzethonium chloride are examples of typical quaternary ammonium antibacterial agents. Other compounds are bis [4- (R-amino) -1-pyridinium] alkanes as disclosed in US Patent No. 4,206,215, issued on June 3, 1980, to Bailey.
    [0050] Other antimicrobials such as copper bisglycinate, copper glycinate, zinc citrate and zinc lactate can also be included. Also useful are enzymes, including endoglycosidase, papain, dextranase, mutanase and mixtures thereof. These agents are disclosed in US Patent No. 2,946,725 and in US Patent No. 4,051,234. Specific antimicrobial agents include chlorhexidine, triclosan, triclosan monophosphate and flavoring oils such as thymol. Triclosan is a preferred antimicrobial agent for inclusion in the present compositions. Triclosan and other agents of this type are disclosed in U.S. Patent No. 5,015,466 and US Patent No. 4,894,220. These agents can be present at levels of 0.01% to 1.5%, by weight of the composition.
    [0051] Titanium dioxide can also be added to the present composition. Titanium dioxide is a white powder that adds opacity to compositions. Titanium dioxide generally comprises from 0.25% to 5%, by weight of the composition.
    [0052] Coloring agents can also be added to the present composition. The coloring agent can be in the form of an aqueous solution, preferably 1% coloring agent in a water solution. Dye solutions generally comprise from 0.01% to 5%, by weight of the composition.
    [0053] A flavoring system can also be added to the compositions. Suitable flavoring components include sesame oil, peppermint oil, peppermint oil, clove bud oil, menthol, anethole, methyl salicylate, eucalyptol, cassia, 1-menthyl acetate, sage, eugenol, oil parsley, oxanone, alpha-irisone, marjoram, lemon, orange, propenyl guaetol, cinnamon, vanillin, ethyl vanillin, heliotropin, 4-cis-heptenal, diacetyl, methyl-to-tert-butylphenyl acetate and mixtures thereof. Soft drinks can also be part of the flavoring system. The preferred refrigerants in the present compositions are the carboxyamide dressing agents such as N-ethyl-p-mentan-3-carboxamide (known commercially as "WS-3") and mixtures thereof. A flavor system is generally used in compositions at levels of 0.001% to 5%, by weight of the composition.
    [0054] Sweetening agents can be added to the compositions. These include saccharin, dextrose, sucrose, lactose, xylitol, maltose, levulose, aspartame, sodium cyclamate, D-tryptophan, dihydrocalcones, acesulfame and mixtures thereof. Various coloring agents can also be incorporated into the present invention. Sweetening agents and coloring agents are generally used in toothpaste at levels of 0.005% to 5%, by weight of the composition.
    [0055] An herb-based agent, including, but not limited to, gold wire extract, honeysuckle extract, and mixtures thereof, may also be present in the compositions of the present invention at levels of 0.01% to 0.05%. Herbal agents are believed to provide antibacterial efficacy. Polyphenols can also be included at levels between 0.01% to 2%. A preferred polyphenol is tea polyphenol.
    [0056] An effective amount of a desensitizing agent can also be incorporated into the present compositions. Desensitizing agents include those selected from alkali metal salts with a chloride, nitrate, sulfate, or acetate of a group II metal or aluminum or polymerizable monomer to occlude the tubules, alkali metal or ammonium nitrate, ammonium oxalate, acid citrus and sodium citrate. Preferred salts are potassium nitrate, potassium citrate, and mixtures thereof. Such desensitizing agents are disclosed, for example, in U.S. Patent No. 5,718,885.
    [0057] A stain-reducing agent such as Plasdone S-630 or aluminum hydrate can still be added to the composition. Plasdone is polyvinylpyrrolidone (PVP) that can be synthesized by polymerizing vinylpyrrolidone. Commercially, it was produced as a series of products with average molecular weights ranging from 10,000 to 700,000. Here, low molecular weights and average molecular weights (10,000 to 100,000) are preferred. In order to remove the stain effectively, the PVP level is preferably 0.5% to 10%, more preferably 1.0% to 7.0%, and even more preferably, 1.5% to 5.0%.
    [0058] The compositions of the present invention optionally comprise a nutrient. Suitable nutrients include vitamins, minerals, amino acids, such as L-arginine, and mixtures thereof. Vitamins include vitamins C and D, thiamine, riboflavin, calcium pantothenate, niacin, folic acid, nicotinamide, pyridoxine, cyanocobalamin, para-aminobenzoic acid, bioflavonoids and mixtures thereof. Nutritional supplements include amino acids (such as L-tryptophan, L-lysine, methionine, threonine, levocarnitine and L-carnitine), lipotropics (such as choline, inositol, betaine and linoleic acid), and mixtures thereof.
    [0059] It is understood that, although the general attributes of each of the previous categories of materials may be different, there may be some common attributes and any given material can serve several purposes within two or more than such categories of materials. All ingredients in the compositions can have functions in addition to their primary function, and can contribute to the overall properties of the composition, including its stability, effectiveness, consistency, taste, taste, odor and so on. Preferably, carrier ingredients are selected for compatibility with other ingredients in the composition.
    [0060] One type of product form of the present invention is a toothpaste. The term "dentifrice" generally indicates formulations that are used to clean the surfaces of the oral cavity. Dentifrice is an oral composition that is not intentionally swallowed for the purpose of systemic administration of therapeutic agents, but is applied to the oral cavity, used to treat the oral cavity and then expectorated. Typically, toothpaste is used in conjunction with a cleaning implement such as a toothbrush, generally applying it to the toothbrush's bristles and then brushing the accessible surfaces of the oral cavity. Preferably, the toothpaste is in the form of a paste or a gel (or a combination thereof).
    [0061] The oral care compositions of the invention are typically in a single stage. However, in some embodiments, the components are physically separated, for example, using a double compartment package. The dentifrice compositions can be a paste, gel, or any configuration or combination thereof. Another embodiment of the present invention includes double-phase or multi-phase compositions comprising the present low-water compositions as one phase and at least one separate phase comprising additional toothpaste components to further improve stability, performance and / or the aesthetics of the toothpaste product. For example, a two-phase composition can comprise a first phase comprising the present low-water composition with polyphosphate and ionic active (s) and a separate second phase comprising additional active agents, such as bleaching agents, preferably, a source of peroxide, or a tooth surface conditioning agent to provide improved cleaning, whitening, anti-stain and taste benefits. Examples of tooth conditioning agents are polysiloxanes and modified polysiloxanes, including diorganopoly siloxanes such as polydimethyl siloxane (PDMS); alkyl and alkoxydimethicone copolyols as C12 to C20 alkyl dimethicone copolyols; and amino alkyl silicones. These siloxane polymers are described, for example, in US Patent Nos. 5,759,523; 6,024,891; 6,123,950; 6,019,962; and 6,139,823.
    [0062] The dispenser for toothpaste compositions can be a tube, pump, or any other suitable container for dispensing toothpaste. In a dual-phase oral composition, each oral composition will be contained in a physically separate compartment from a dispenser. and are dispensed side by side. Usage Methods
    [0063] In the practice of the modalities, the user only needs to apply the composition for oral care here, to the surfaces of the teeth of a human or animal, in the desired areas, in order to obtain a desired effect, for example, reduction or plaque prevention, whitening, breath freshening, caries prevention, pain relief, gum health, tartar control, erosion control, etc. The use of toothpastes to control erosion of the tooth surface, or to prevent tooth decay. demineralization, is known and described, for example, in US Patent No. 6,685,920. The compositions can also be applied to other surfaces of the oral cavity, such as the gums or mucous tissues, but it is believed that the benefits are best achieved when the toothpaste compositions are applied to the teeth. The toothpaste composition may come into contact with the tooth and / or surface of the oral cavity, either directly or indirectly, however, it is preferred that the toothpaste composition be applied directly. The toothpaste composition can be applied by any means, but is preferably applied with a brush or by rinsing with an aqueous toothpaste. The application can be at least once a day, although up to five times a day may be preferred, and can be carried out over a period of time, for example, a week, up to a year, up to three years, or during all life.
    [0064] The manufacture of the oral composition of the present invention can be carried out by any of several conventional techniques for the production of such compositions. For example, methods of preparing dentifrices are well known, for example, as described in US Patent no. 3,966,863; US Patent No. 3,980,767; US Patent No. 4,328,205; and US Patent No. 4,358,437. To make a dentifrice, a vehicle can be prepared containing a humectant, for example, one or more among glycerin, glycerol, sorbitol and propylene glycol, thickening agents and antibacterial agent such as triclosan, and the vehicle and a mixture of anionic and amphoteric surfactants are added, followed by mixing with a polishing agent, as well as fluorine salts, with the premix. Finally, the flavoring agent is mixed and the pH is adjusted to between 6.8 to 7.0.
    [0065] Some embodiments of the present invention provide an oral care composition (Composition 1) comprising: (a) an orally acceptable vehicle; (b) a source of fluoride ions; (c) a source of tin ions; (d) an insoluble source of zinc ions; (e) a buffer system comprising citric acid, wherein the amount of citric acid is at least 1% by weight of the composition, and where the composition has a total water content of less than 15% by weight, for example : 1.1. Composition 1, wherein the amount of citric acid is 0.5 to 4% by weight, or 1 to 3% by weight, or 1.1 to 1.5% by weight or 1.8 to 2.2% by weight or 1.3% or 2% by weight, 1.2. Any of the above compositions in which the insoluble source of zinc ions comprises a zinc salt of an organic acid; 1.3. Any of the foregoing compositions in which the insoluble source of zinc ions comprises zinc oxide, zinc phosphate, zinc pyrophosphate or a mixture thereof; 1.4. Any of the above compositions where the source of fluoride ions is a salt selected from tin fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride (for example , N'-octadecyltrimethylendiamine-N, N, N'-tris (2-ethanol) dihydrofluorohydrate, ammonium fluoride, titanium fluoride, hexafluoro sulfate, and combinations thereof; 1.5. Any of the foregoing compositions in which the source of tin ions is selected from among tin fluoride, tin chloride dihydrate, tin acetate, tin tartrate, tin and sodium citrate, or a mixture thereof; 1.6. Any of the foregoing compositions wherein the fluoride ion source and the tin ion source comprise tin fluoride; 1.7. Any of the foregoing compositions comprising at least one polyphosphate salt selected from the group consisting of inorganic polyphosphate salts that have three phosphorus atoms or less. 1.8. Composition 1.5, in which at least one polyphosphate is selected from the group consisting of tetrasodium pyrophosphate, sodium tripolyphosphate, and mixtures thereof; wherein the total polyphosphate comprises from 1 to 10% by weight of the composition; 1.9. Any of the foregoing compositions, wherein the buffer system comprises a mixture of citric acid and trisodium citrate; 1.10. Any of the foregoing compositions comprising a thickening agent which comprises, in combination, cross-linked polyvinylpyrrolidone and a gum; 1.11. Any of the foregoing compositions comprising a thickening agent comprising a cellulose, a synthetic block copolymer of ethylene oxide and propylene oxide, or a mixture thereof; 1.12. Any of the above compositions, in which the source of zinc ions is present in an amount of 0.1 to 2% by weight, or from 0.5 to 1.5% by weight or from 0.9% to 1, 1% by weight; 1.13. Any of the above compositions, wherein the tin ion source is present in an amount of 0.05% to 5% by weight, or 0.1% to 1% by weight; or 0.35 to 0.55% by weight. 1.14. Any of the above compositions, wherein the amount of the fluoride ion source is 0.1% to 5%, or 0.2% to 1%, or 0.3 to 0.6% by weight of the composition total; 1.15. Any of the above compositions, wherein the composition has a total water content of less than 20%, or less than 15%, or less than 15% to more than 10% by weight, based on the weight of the composition; 1.16. Any of the foregoing compositions, wherein the combined metal ion source is present in an amount of 0.15% to 7%, by weight, or 0.6 to 2.5%, or 1.25% to 1.65%, by weight of the composition; 1.17. Any of the foregoing compositions, which comprises a methyl vinyl ether / maleic anhydride copolymer with an average molecular weight (MW) of 30,000 to 1,000,000, for example, 300,000 to 800,000; 1.18. Any of the foregoing compositions comprising L-arginine in the form of an orally acceptable or free salt; 1.19. Any of the foregoing compositions comprising additional buffering agents, for example, sodium phosphate buffer (for example, monobasic sodium phosphate and disodium phosphate); 1.20. Any of the foregoing compositions comprising a humectant, for example, selected from, sorbitol, propylene glycol, polyethylene glycol, xylitol, and mixtures thereof; 1.21. Any of the foregoing compositions further comprising an abrasive or particulate; 1.22. The above composition, in which abrasive or particulate is selected from sodium bicarbonate, calcium phosphate (eg, dicalcium phosphate dihydrate), calcium sulfate, precipitated calcium carbonate, silica (eg hydrated silica) , iron oxide, aluminum oxide, perlite, plastic particles, for example, polyethylene, and combinations thereof; 1.23. Any of the foregoing compositions comprising an abrasive in an amount of 15% by weight to 70% by weight of the total weight of the composition; 1.24. Any of the foregoing compositions comprising one or more surfactants, for example, selected from anionic, cationic, zwitterionic, and non-ionic surfactants, and mixtures thereof, for example, comprising an anionic surfactant, for example, a surfactant selected from sodium lauryl sulfate, sodium lauryl sulfate ether, and mixtures thereof, for example, in an amount of 0.3% to 4.5% by weight; 1.25. Any of the foregoing compositions further comprising one or more polymers selected from polyethylene glycols, polysaccharides (for example, cellulose derivatives, for example, carboxymethyl cellulose, polysaccharide gums, for example, xanthan gum or carrageenan gum), and combinations of the themselves; 1.26. Any of the foregoing compositions comprising one or more antibacterial agents, for example, comprising an antibacterial agent selected from halogenated diphenyl ether (for example, triclosan), herbal extracts and essential oils (for example, rosemary extract, tea extract , magnolia extract, thymol, menthol, eucalyptol, geraniol, carvacrol, citral, hinocytol, catechol, methyl salicylate, epigallocatechin gallate, epigallocatechin, gallic acid, miswak extract, sea buckthorn extract), antiseptics by bis chlorhexidine, alexidine or octenidine), quaternary ammonium compounds (eg cetyl pyridinium chloride (CPC), benzalkonium chloride, tetradecyl pyridinium chloride (TPC), N-tetradecyl-4-ethylpyridinium chloride (TDEPC )), phenolic antiseptics, hexetidine, octenidine, sanguinarine, povidone iodine, delmopinol, salifluor, metal ions (eg zinc salts, eg zinc citrate, stanth salts ho, copper salts, iron salts), sanguinarine, propolis and oxygenation agents (for example, hydrogen peroxide, buffered sodium peroxyborate or peroxycarbonate), phthalic acid and its salts, monopertallic acid and its salts and esters, stearate ascorbyl, oleosilic sarcosine, alkyl sulfate, dioctyl sulfosuccinate, salicylanilide, domiphene bromide, delmopinol, octapinol and other piperidine derivatives, nicine preparations, chlorite salts; and mixtures of any of the above; for example, comprising triclosan or cetyl pyridinium chloride; 1.27. Any of the foregoing compositions comprising a bleaching agent, for example, one selected from the group consisting of peroxides, metal chlorites, perborates, percarbonates, peracids, hypochlorites, and combinations thereof; 1.28. Any of the foregoing compositions further comprising hydrogen peroxide or a source of hydrogen peroxide, for example, urea peroxide or a salt or peroxide complex (for example, such as peroxy-phosphate, peroxy-carbonate, perborate, peroxide). silicate, or persulfate salts, for example, calcium peroxide phosphate, sodium perborate, sodium carbonate peroxide, sodium peroxide phosphate and potassium persulfate); 1.29. Any of the foregoing compositions further comprising a source of calcium and phosphate selected from (i) calcium and glass complexes, for example, sodium and calcium phosphosilicates, and (ii) protein-calcium complexes, for example, phosphopeptide casein - amorphous calcium phosphate; 1.30. Any of the foregoing compositions further comprising, a soluble calcium salt, for example, selected from calcium sulfate, calcium chloride, calcium nitrate, calcium acetate, calcium lactate, and combinations thereof; 1.31. Any of the foregoing compositions further comprising, a physiologically or orally acceptable potassium salt, for example, potassium nitrate or potassium chloride, in an amount effective to reduce dentin sensitivity; 1.32. Any of the above compositions in the form of a toothpaste, for example, a toothpaste, for example, a clear gel or opaque toothpaste; 1.33. Any of the above compositions in the form of a single phase; 1.34. Any of the above compositions comprising one or more of the following in the quantities recited:


    1.35. Any of the foregoing compositions that do not contain methyl vinyl ether - maleic anhydride copolymer; 1.36. A method of treating or preventing a disease or condition of the oral cavity comprising contacting a surface of the oral cavity of a patient in need of it, with the composition of any of the compositions mentioned above; 1.37. The method of the previous modality, which is a method for treating and preventing the accumulation of plaque or preventing dental erosion.
    [0066] The following examples are additionally illustrative of the preferred modalities, but it should be understood that the invention is not limited to them. EXAMPLES Example 1 Procedure
    [0067] Four formulations are prepared with the ingredients indicated for Formula A, with the amounts of CMC and citric acid, TKPP, SAPP and STPP varied as indicated in Tables 1 and 2.
    [0068] The technique for determining water-soluble tin and water-soluble zinc in formulations is by flame atomic absorption spectroscopy (FAAS). A suitable double-beam atomic absorption spectrophotometer equipped with an air-acetylene burner and correction deuterium bottom, for example, Varian SpectrAA 220FS, can be used. In addition, a suitable zinc cavity cathode lamp and AA grade acetylene can be used. Water-soluble zinc or tin can be measured in the FAAS compositions after diluting a sample in water and comparing with zinc or tin standards. Part of the formulation is dispersed with water, the solutions are transferred to a volumetric flask, diluted to volume with water and centrifuged. Tin or zinc is detected in the supernatant by atomic absorption spectrometry and quantified by comparing the absorbance of the sample solution to the absorbance of the known calibrated external standards of tin or zinc concentration. To determine total tin or zinc, instead of dispersing the samples in water, the samples are digested with a suitable acid mixture, for example, hydrochloric, nitric, or hydrofluoric acid, and over a steam bath.
    [0069] The formulas are aged at 40 ° C for up to 13 weeks. The levels of total tin, total zinc, soluble tin and soluble zinc are determined at various time points. Table 1


    Table 2
    ■ Tin Fluoride Solubility: 31g / 100 mL (0 ° C), 35g / 100 mL (20 ° C) Formula A


    Results
    [0070] Comparative Example - Previous work with a formula comprising a source of soluble zinc (2% by weight of zinc citrate) and 0.454% by weight of tin fluoride with 0.6% by weight of citric acid / 3, 0% by weight of trisodium citrate. This formula had an initial ten-water-soluble amount of just 0.39% by weight, which decreased slightly to 0.34% by weight after 12 weeks of aging. The amount of tin remained constant from its initial solubility to the end of the 12-week aging period (ranging from 0.31% by weight to 0.36% by weight).
    [0071] Surprisingly, formulas with or without CMC with the same amount (0.454% by weight) of tin fluoride and a smaller amount (1% by weight) of less soluble zinc source (ZnO) showed greater initial solubility when more than 1% by weight of citric acid was used (ranging from 0.62% by weight to 0.69% by weight) and this higher level of solubility was maintained despite 13 weeks of aging (0.55% by weight) to 0.63% by weight).
    [0072] Furthermore, when the amount of citric acid was increased to 2%, the initial amount of soluble tin and the amount after 13 weeks of aging (0.32% by weight to 0.35% by weight) was comparable to of the ranges measured in the Comparative Example.
    [0073] As those skilled in the art will appreciate, numerous changes and modifications can be made to the modalities described here without departing from the spirit of the invention. All these variations are intended to be part of the scope of the appended claims.
    权利要求:
    Claims (15)
    [0001]
    1. Composition for oral care, characterized by the fact that it comprises in a single phase: (a) an orally acceptable vehicle; (b) a source of fluoride ions; (c) a source of tin ions; (d) an insoluble source of zinc ions; (e) a buffer system comprising citric acid, wherein the amount of citric acid is at least 1% by weight of the composition, and where the composition has a total water content of less than 15% by weight, based on in the weight of the composition.
    [0002]
    2. Composition according to claim 1, characterized by the fact that the amount of citric acid is 1 to 3% by weight, or 1.1 to 1.5% by weight or 1.8 to 2.2% by weight, based on the weight of the composition.
    [0003]
    3. Composition according to claim 1 or 2, characterized in that the insoluble source of zinc ions comprises a zinc salt of an organic acid, optionally in which the zinc salt is selected from zinc oxide , zinc phosphate, zinc pyrophosphate or a mixture thereof.
    [0004]
    Composition according to any one of claims 1 to 3, characterized in that the source of fluoride ions and the source of tin ions comprise tin fluoride.
    [0005]
    Composition according to any one of claims 1 to 4, characterized in that it comprises at least one polyphosphate salt selected from the group consisting of inorganic polyphosphate salts that has equal to or less than three phosphorus atoms , optionally in which the inorganic polyphosphate salts are selected from tetrasodium pyrophosphate, sodium tripolyphosphate or mixtures thereof and are present in a total polyphosphate concentration of 1 to 10% by weight of the composition.
    [0006]
    Composition according to any one of claims 1 to 5, characterized in that the buffer system comprises a mixture of citric acid and trisodium citrate.
    [0007]
    Composition according to any one of claims 1 to 6, characterized in that it comprises polyvinylpyrrolidone, a gum, or a mixture thereof.
    [0008]
    Composition according to any one of claims 1 to 7, characterized in that it comprises a modified cellulose, such as carboxymethyl cellulose.
    [0009]
    Composition according to any one of claims 1 to 8, characterized in that it further comprises at least one humectant selected from the group consisting of glycerin, polyethylene glycol, propylene glycol, and mixtures thereof.
    [0010]
    10. Composition according to any one of claims 1 to 9, characterized in that the composition is a toothpaste comprising one or more of an abrasive, a surfactant, a foaming agent, a vitamin, a polymer, a drying agent. bleaching, an enzyme, a humectant, a thickener, an antimicrobial agent, a preservative, L-arginine, a flavoring or coloring agent.
    [0011]
    11. Composition according to any one of claims 1 to 10, characterized by the fact that it is in a single phase.
    [0012]
    12. Composition for oral care, characterized by the fact that it comprises: (a) 0.5 to 3% by weight of citric acid; (b) 0.5 to 10% by weight of trisodium citrate; (c) 0.1 to 5% by weight of zinc oxide; (d) 0.1 to 5% by weight of tin fluoride; (e) 10 to 50% by weight of glycerin; (f) 1 to 25% by weight of propylene glycol; optionally comprising one or more of: (g) 0.1 to 12% by weight of xanthan gum; (h) 0.25 to 10% by weight of polyvinylpyrrolidone (PVP); (i) 0.2 to 1.5% by weight of carboxymethylcellulose (CMC); (i) 5 to 60% by weight of silica (total); (k) 0.1 to 10% by weight of tetrasodium pyrophosphate (TSPP); (l) 0 to 5% by weight of sodium acid pyrophosphate (SAPP); (m) 0.1 to 10% by weight of sodium tripolyphosphate (STPP); (n) 0.1 to 10% by weight of sodium lauryl sulfate (SLS); (o) 0.1 to 10% by weight of cocoamidopropyl betaine.
    [0013]
    13. Oral care composition according to claim 12, characterized in that it comprises: (a) 1.1 to 1.5% by weight or 1.8 to 2.2% by weight of citric acid; (b) 2 to 4% by weight of trisodium citrate; (c) 0.5 to 2% by weight of zinc oxide; (d) 0.1 to 2% by weight of tin fluoride; (e) 10 to 50% by weight of glycerin; (f) 2 to 10% by weight of propylene glycol; optionally comprising one or more of: (g) 0.1 to 0.5% by weight of xanthan gum; (h) 0.25 to 10% by weight of polyvinylpyrrolidone (PVP); (i) 0.3 to 0.9% by weight of carboxymethylcellulose (CMC); (j) 10 to 40% by weight of silica (total); (k) 1 to 4% by weight of tetrasodium pyrophosphate (TSPP); (l) 0.5 to 1.5% by weight of sodium acid pyrophosphate (SAPP); (m) 1 to 4% by weight of sodium tripolyphosphate (STPP); (n) 1.2 to 2.5% by weight of sodium lauryl sulfate (SLS); (o) 0.5 to 2% by weight of cocoamidopropyl betaine.
    [0014]
    14. Oral care composition according to claim 12, characterized in that it comprises: (a) 1.1 to 1.5% by weight or 1.8 to 2.2% by weight of citric acid; (b) 2.9 to 3.1% by weight of trisodium citrate; (c) 0.9 to 1.1% by weight of zinc oxide; (d) 0.4 to 0.6% by weight of tin fluoride; (e) 10 to 50% by weight of glycerin; (f) 6 to 8% by weight of propylene glycol; optionally comprising one or more of: (g) 0.275 to 0.325% by weight of xanthan gum; (h) 0.25 to 10% by weight of polyvinylpyrrolidone (PVP); (i) 0.65 to 0.75% by weight of carboxymethylcellulose (CMC); (j) 22 to 26% by weight of silica (total); (k) 1.75 to 2.25% by weight of tetrasodium pyrophosphate (TSPP); (l) 0.9 to 1.1% by weight of sodium acid pyrophosphate (SAPP); (m) 2.75 to 3.25% by weight of sodium tripolyphosphate (STPP); (n) 1.5 to 1.75% by weight of sodium lauryl sulfate (SLS); (o) 0.75 to 1.25% by weight of cocoamidopropyl betaine.
    [0015]
    15. Use of: (a) an orally acceptable vehicle; (b) a source of fluoride ions; (c) a source of tin ions; (d) an insoluble source of zinc ions; (e) a buffer system comprising citric acid, characterized in that it is in the preparation of an oral care composition as defined in claim 1 for the treatment or prevention of a disease or condition of the oral cavity in a patient in need of it, wherein the disease or condition of the oral cavity is biofilm formation, plaque formation, oral inflammation or a combination thereof.
    类似技术:
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    MXPA02008963A|2003-02-10|Stable dentrifice compositions comprising polyphosphate, fluoride, and stannous.
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    同族专利:
    公开号 | 公开日
    IL249262D0|2017-02-28|
    BR112016028403A2|2018-06-26|
    CA2952921A1|2015-12-23|
    RU2016149576A3|2018-07-23|
    AR100925A1|2016-11-09|
    RU2679416C2|2019-02-08|
    RU2016149576A|2018-07-23|
    EP3157638B1|2018-08-08|
    MX359754B|2018-10-01|
    US20190133903A1|2019-05-09|
    TW201605482A|2016-02-16|
    US20170319447A1|2017-11-09|
    CN106470737A|2017-03-01|
    ZA201607202B|2019-12-18|
    WO2015195140A1|2015-12-23|
    EP3157638A1|2017-04-26|
    CA2952921C|2021-06-15|
    AU2014398221B2|2017-10-05|
    CN106470737B|2020-02-14|
    AU2014398221A1|2016-12-15|
    US10154948B2|2018-12-18|
    MX2016015772A|2017-02-27|
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    法律状态:
    2019-07-30| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-05-05| B06A| Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]|
    2020-09-01| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2020-12-15| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/06/2014, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    PCT/US2014/043427|WO2015195140A1|2014-06-20|2014-06-20|Oral compositions containing zinc, stannous and fluoride ion sources|
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