• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
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    • 专利摘要:
    SYSTEMS AND METHODS FOR ANALYSISBIOCHEMISTRY INCLUDING A BASE INSTRUMENT AND A REMOVABLE CARTRIDGE.Systems and Methods for Conducting Designated Reactions Using abase instrument and a removable cartridge. Removable cartridge includes a fluid network that fluidly receives and guides a sampleto conduct the designated reactions. The removable cartridgealso includes a flow control valve that is operativelycoupled to the fluidic network and is mobile in relation to the fluidic network forcontrol flow of the biological sample through it. the cartridgedetachable is configured to separately engage an instrument ofbase. The base instrument includes a valve actuator that engages theremovable cartridge flow control valve. A montage ofdetection held by at least one between the removable cartridge or thebase instrument can be used to detect the designated reactions.
    公开号:BR112016027815A2
    申请号:R112016027815-1
    申请日:2015-05-27
    公开日:2021-07-20
    发明作者:Alex Aravanis；Boyan Boyanov；M. Shane Bowen；Dale Buermann；Alexander Hsiao；Behnam Javanmardi；Tarun Khurana；Poorya Sabounchi；Hai Quang Tran
    申请人:Illumina, Inc.；
    IPC主号:
    专利说明:

    ASSIGNMENT OF INVENTORS Dossier No.: IP-1205-PRV Title: SYSTEMS AND METHODS FOR BIOCHEMICAL ANALYSIS
    INCLUDING A BASE INSTRUMENT AND A REMOVABLE CARTRIDGE US Order No.: 62/003,264 Filing Date: May 27, 2014 Inventor(s): Alex Aravanis, Majid Aghababazadeh, Boyan Boyanov, M. Shane Bowen, Dale Buermann, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana and Hai Quang Tran WHEREAS the above-identified inventors (collectively “The Assignors”) have made certain new and useful inventions, discoveries and improvements (the “inventions”), for which the Assignors have filed the application(s) (s) listed above and now wishes to transfer all rights, title and interests in: . inventions, . application(s) listed above, and any other applications for a patent, design, utility model, certificate of invention, trademark, or trade mark, in any country or in accordance with any international or regional authority (for example, WIPO/PCT, EPO, ARIPO, EAPO, OAPI) to the extent that some or all of its material is disclosed and is entitled to the priority benefit on the order(s) listed above, including provisional orders, 1 /7 continuation, splitting, continuation in part, re-dispatching, and re-examination requests (collectively "the order(s)",
    . the benefit of an earlier filing date and right to claim priority for inventions and order(s) in accordance with applicable law and treaties, including the Paris Convention for the Protection of Industrial Property as revised and amended and 35 USC § 119, 120,
    . any rights arising from the publication of the
    application(s), such as 35 U.S.C. § 154(d), Art. 67(1) EPC,
    . any Letters of Patent or Certificates of Invention that may be issued or granted from the application(s),
    including reissued patents, review certificates,
    renewals and any rights resulting from an extension or adjustment of a patent term, and
    . any rights arising from the invention in accordance with the laws and conventions protecting copyright,
    trademark, commercial image or other industrial property,
    (collectively, “the IP rights”), and
    WHEREAS ILLUMINA, INC., a commercial company of
    Delaware having commercial location at 5200 Illumina Way, San
    Diego, CA 92122, United States of America, wishes to acquire all rights, title and interests for itself,
    their successors, and their nominees (collectively “the
    2/7
    Assignee") in the IP rights by a written instrument, 35 U.S.C. § 261;
    NOW THEREFORE, whoever may be interested, know that for good and valuable compensation, whose receipt and sufficiency we hereby acknowledge and hereby waive the right to any additional compensation relating to IP rights;
    We warrant and represent to the Assignee that we have all rights to transfer our rights, title and interests in the IP Rights without encumbrance, and that we have not made any prior assignment, license, concession or mortgage to another, or made any agreement with another, that would affect our rights, ownership and interests in the Rights of IP;
    By this assignment and by virtue of any prior agreements to assign, we hereby assign, transfer, transfer and sell our entire rights, title and interest in the IP Rights to the Assignee, including any claims or causes of action for damages or other remedies that originate from any previous violation of the
    IP rights, to and be for the full benefit of
    Assignee of the IP Rights in full as they would have been retained by us had such Assignment not been made;
    We authorize the Assignee and its legal representatives to:
    3/7
    (a) Insert in this Assignment any supplemental information to make identification more complete for any of the Application(s) or Letters already listed above,
    (b) process the order(s), file new orders for the invention(s), and take all acts permitted by law to protect and enforce IP rights,
    (c) Request that Charters and Certificates of
    Invention are issued and granted to and in the name of the Assignee by the issuing or granting authority, such as the Commissioner for Patents of the
    United States, 37 C.F.R. § 3.81; and
    We agree with the Assignee that we and our legal representatives, heirs and executors will carry out all acts deemed necessary or desirable by the Assignee to allow and help ensure all rights, ownership and interests in
    IP rights so that the Assignee can benefit from this Assignment, including:
    (a) Communicate to the Assignee all facts known to us that refer to the history and extent of my individual contribution to the
    IP rights, including the circumstances of the
    4/7 conception of the invention and its development and reduction for practice, and provide documents or supporting items under my control, (b) Assist in the preparation of the order(s) and its execution by the Assignee, 37 C.F.R. § 3.71, and in the execution of IP Rights, including making, executing, and delivering to the Assignee any other necessary documents, such as additional application documents, declaration, sworn statements, waivers, petitions or assignments and (c) Assist and cooperate in processes administrative and legal, including giving oral and written testimony, So that these are carried out without additional compensation, except for reasonable actual expenses to be reimbursed by the Assignee.
    We further agree with the Assignee that we will not perform any future act, sign any subsequent document, or make any subsequent agreement with another person or party that is in conflict with this Assignment, who intends to transfer any right, ownership or interest in the IP Rights that are the subject matter of this Assignment, unless agreed in writing by the Assignee or prevents the Assignee from receiving the full benefit of the business pursuant to this Assignment.
    5/7
    If any provision of this Assignment is found to be invalid or unenforceable, the provision will be executed to the maximum extent permissible to put into effect the intent of the Assignors and Assignee, and the remainder of this Assignment will not be affected, but will continue in full force and effect .
    This document will be enforceable by each Assignor in parts, and the Assignment will be in force and recordable for each Assignor from the date of signature of that Assignor.
    Inventor's legal name: Alex Aravanis In testimony of which, I affixed my signature and seal on February 11, 2015.
    Illegible signature Inventor's legal name: Boyan Boyanov In testimony of which, I affixed my signature and seal on February 19, 2015.
    Illegible signature Inventor's legal name: M. Shane Bowen In testimony of which, I affixed my signature and seal on February 10, 2015.
    Illegible signature Inventor's legal name: Dale Buermann In testimony of which, I affixed my signature and seal on March 23, 2015.
    Illegible signature 6/7
    Inventor's legal name: Alexander Hsiao In testimony of which, I affixed my signature and seal on the 24th of March 2015.
    Illegible signature Inventor's legal name: Behnam Javanmardi In testimony of which, I affixed my signature and seal on the 10th day of February 2015.
    Illegible signature Inventor's legal name: Tarun Khurana In testimony of which, I affixed my signature and seal on February 2, 2015.
    Illegible signature Inventor's legal name: Hai Quang Tran In testimony of which, I affixed my signature and seal on the 13th of February 2015.
    Illegible signature 7/7
    权利要求:
    Claims (60)
    [1]
    1. System, characterized in that it comprises: a removable cartridge having a cartridge housing and including a fluidic network disposed within the cartridge housing, the fluidic network configured to fluidly receive and orient a biological sample to conduct at least one between analysis of sample or sample preparation, the removable cartridge also including a flow control valve that is operatively coupled to the fluidic network and movable relative to the fluidic network to control flow of the biological sample therethrough, the cartridge housing including a side of housing that defines an exterior of the removable cartridge and allows operative access to the flow control valve; a base instrument having a control side configured to separately engage the housing side of the removable cartridge, the housing and control sides collectively defining a system interface, the base instrument including a valve actuator that engages the control valve. flow through the system interface; and a detection assembly retained by at least one between the removable cartridge or base instrument, the detection assembly including an imaging detector and a reaction chamber that is in flow communication with the fluidic network,
    the imaging detector configured to detect designated reactions within the reaction chamber.
    [2]
    2. System according to claim 1, characterized in that the control side and the housing side are generally flat and facing each other, wherein the system interface is a single-sided interface in which the instrument base and the removable cartridge are operatively coupled together through the housing side and control side only.
    [3]
    3. System according to claim 2, characterized in that the base instrument and the removable cartridge are operatively coupled so that the base instrument and the removable cartridge are secured together at the system interface with at least one between a fluidic housing, an electrical coupling, or a thermal coupling established through the system interface.
    [4]
    4. System according to any one of claims 1 to 3, characterized in that the control side represents a top of the base instrument, with respect to gravity, so that the removable cartridge sits on and is supported by the instrument of base.
    [5]
    A system according to any one of claims 1 to 4, characterized in that the valve actuator includes an elongated actuator body that extends through the housing side and into the cartridge housing.
    [6]
    6. System according to any one of claims 1 to 5, characterized in that the flow control valve includes an elongated actuator body that extends through the control side and into the base instrument.
    [7]
    7. System according to any one of claims 1 to 6, characterized in that the base instrument has an instrument side that faces in an opposite direction with respect to the control side, the base instrument having a dimension of instrument extending between the control side and the instrument side, the base instrument and the removable cartridge having a combined dimension that is larger than the instrument dimension.
    [8]
    8. System according to any one of claims 1 to 7, characterized in that each between the removable cartridge and the base instrument includes a set of electrical contact contacts, the sets of contacts being electrically coupled together at the interface of system.
    [9]
    9. System according to any one of claims 1 to 8, characterized in that the housing side is a first housing side and the cartridge housing further comprising a second housing side, the first and second housing sides facing in different directions, the system interface being a mutilated interface in which the base instrument and the removable cartridge are operatively coupled together along each of the first and second housing sides.
    [10]
    10. System according to claim 9, characterized in that the first and second housing sides are generally perpendicular to each other, the base instrument having an instrument housing that includes first and second control sides that face toward perpendicular directions and form an open side recess of the base instrument, the removable cartridge being disposed in the open side recess so that the first and second housing sides engage the first and second control sides.
    [11]
    11. The system of claim 10, characterized in that the valve actuator includes an elongated body extending across the system interface between the first housing side and the first control side, the second housing side and the second control side including respective contact sets of electrical contacts, the contact sets being electrically coupled together across the system interface.
    [12]
    12. System according to claim 9, characterized in that the first and second housing sides face in generally opposite directions, the base instrument having an instrument side and a cartridge receiving slot that opens to the instrument side, the removable cartridge being disposed in the cartridge receiving slot.
    [13]
    13. System according to claim 12, characterized in that the removable cartridge and the base instrument are fluidly coupled along the first housing side and electrically coupled along the second housing side.
    [14]
    14. System according to claim 12, characterized in that the base instrument includes a locking mechanism that engages at least one between the first housing side or the second housing side to retain the removable cartridge in the housing instrument. base.
    [15]
    15. System according to any one of claims 1 to 14, characterized in that each of the removable cartridge and base instrument includes a flow orifice, the flow orifices fluidly coupling with each other at the system interface.
    [16]
    16. A system according to any one of claims 1 to 15, characterized in that it further comprises a locking mechanism attached to at least one of the removable cartridge or base instrument, the locking mechanism configured to detachably secure the cartridge housing to the base instrument.
    [17]
    17. System according to any one of claims 1 to 16, characterized in that the imaging detector is retained by the base instrument and the reaction chamber is retained by the removable cartridge.
    [18]
    18. System according to any one of claims 1 to 17, characterized in that the flow control valve includes a flexible membrane that is configured to control the flow of the biological sample through the fluidic network, the flexible membrane being flexed between first and second conditions by the valve actuator.
    [19]
    19. System according to any one of claims 1 to 18, characterized in that the housing side of the cartridge housing includes an access opening therethrough that receives the valve actuator.
    [20]
    20. System according to any one of claims 1 to 19, characterized in that the flow control valve includes a rotary valve that is configured to control the flow of fluid through the fluidic network, the rotary valve being rotated by the valve actuator.
    [21]
    21. System according to any one of claims 1 to 20, characterized in that the base instrument includes a thermal block and the fluidic network of the cartridge housing includes a sample channel where designated reactions with the biological sample take place, the housing side including an access opening that extends along the sample channel and is configured to receive the thermal block to change a temperature of the sample channel.
    [22]
    22. System according to any one of claims 1 to 21, characterized in that the fluidic network includes a plurality of channels and a storage module, the storage module including a plurality of reservoirs for storing reagents that are used to at least one between sample preparation or sample analysis.
    [23]
    23. System according to any one of claims 1 to 22, characterized in that the base instrument includes a system controller having a valve control module configured to control the operation of the valve driver to control sample flow biological through the fluidic network.
    [24]
    24. System according to claim 23, characterized in that the valve control module is configured to control the operation of the valve driver to conduct a sequencing synthesis protocol (SBS).
    [25]
    25. Method of sequencing nucleic acids, the method being characterized in that it comprises: providing a removable cartridge having a cartridge housing, a fluidic network disposed in the cartridge housing, and a flow control valve that is operatively coupled to the fluidic network and movable with respect to the fluidic network, wherein the cartridge housing includes a housing side defining an exterior of the removable cartridge; contacting the removable cartridge with a base instrument, wherein the housing side of the removable cartridge separately engages a control side of the base instrument to collectively define a system interface, wherein the base instrument comprises a valve actuator that operatively engages the flow control valve through the system interface; fluidly orienting a biological sample to flow through the fluidic network of the cartridge to conduct at least one of sample analysis or sample preparation in the cartridge, wherein the biological sample is directed to flow into a reaction chamber, wherein the flow of the biological sample is controlled by action of the valve actuator on the flow control valve; and imaging the biological sample in the reaction chamber using a detection assembly that is retained by at least one of a removable cartridge or base instrument.
    [26]
    26. Method according to claim 25, characterized in that it further comprises removing the removable cartridge from the base instrument.
    [27]
    27. The method of claim 26, further comprising contacting a second removable cartridge with the base instrument, wherein the housing side of the second removable cartridge separately engages the control side of the base instrument to collectively define the system interface.
    [28]
    28. Method according to claim 27, characterized in that it fluidly orients the biological sample and imaging the biological sample are repeated multiple times in sequence.
    [29]
    29. Method according to any one of claims 25 to 28, characterized in that it further comprises sealing the biological sample inside a sample preparation region of the fluidic network and amplifying the biological sample while the biological sample is sealed inside of the sample preparation region.
    [30]
    30. Method according to any one of claims 25 to 29, characterized in that the flow control valve includes a movable valve having at least one flow channel extending between valve orifices, the valve actuator configured to move the mobile between different positions.
    [31]
    31. Method according to claim 30, characterized in that the movable valve is in a sample position when the biological sample flows through the flow channel and is directed into the reaction chamber, the method further comprising moving move the valve to a component position and flow a reagent through the flow channel into the reaction chamber, the reagent reacting with the biological sample in the reaction chamber.
    [32]
    32. The method of claim 31, characterized in that the component position includes a plurality of component positions, the method further comprising moving the movable valve between the component positions in accordance with a predetermined sequence for flowing reactants into the reaction chamber.
    [33]
    33. Method according to any one of claims 25 to 32, characterized in that the biological sample includes nucleic acids and the predetermined sequence is in accordance with a sequencing by synthesis protocol (SBS).
    [34]
    34. Method according to any one of claims 25 to 33, characterized in that a flow cell includes the reaction chamber, the biological sample being immobilized on one or more surfaces of the flow cell.
    [35]
    35. Removable cartridge, characterized in that it comprises: a cartridge housing having a sample port that opens to an exterior of the cartridge housing and is configured to receive a biological sample, the cartridge housing having a set of electrical contacts and a mechanical interface that are exposed to the outside, the cartridge housing configured to be detachably coupled to a base instrument; a fluidic network comprising a plurality of channels, a reaction chamber, and a storage module, the storage module including a plurality of reservoirs for storing reagents, the fluidic network configured to direct reactants from the reservoirs to the reaction chamber, wherein the mechanical interface is mobile with respect to the fluidic network to control fluid flow through the fluidic network; and an imaging device disposed within the cartridge housing and positioned to detect designated reactions in the reaction chamber, wherein the imaging device is electrically coupled to the set of electrical contacts to communicate with the base instrument, the mechanical interface configured to be moved by a base instrument when the removable cartridge is attached to the base instrument.
    [36]
    36. Removable cartridge according to claim 35, characterized in that the mechanical interface includes a channel valve that is configured to control the flow of fluid through one of the channels of the fluidic network.
    [37]
    37. Removable cartridge according to claim 35 or claim 36, characterized in that the cartridge housing includes an access opening that allows access to the mechanical interface.
    [38]
    38. Removable cartridge according to claim 35, characterized in that the mechanical interface includes a rotary valve.
    [39]
    39. Removable cartridge according to any one of claims 35-38, characterized in that the cartridge housing includes an access opening that is exposed to the outside and the channels include a sample channel that is in flow communication with the sample hole, the access opening extending along the sample channel and configured to receive a thermal block to control a temperature of the sample channel.
    [40]
    40. Removable cartridge according to any one of claims 35 to 39, characterized in that the cartridge housing includes a fluid coupling orifice that is exposed to the outside and is in flow communication with the fluidic network, the orifice of fluid coupling configured to engage an instrument port to receive fluid therethrough.
    [41]
    41. Removable cartridge according to any one of claims 35 to 40, characterized in that the cartridge housing includes first and second housing sides that face in opposite directions, the first housing side including the set of electrical contacts , the second housing side including the mechanical interface.
    [42]
    42. Removable cartridge according to any one of claims 35 to 41, characterized in that it further comprises a locking mechanism attached to the cartridge housing, the locking mechanism configured to detachably attach the cartridge housing to the base instrument.
    [43]
    43. Removable cartridge according to any one of claims 35 to 42, characterized in that the storage module includes reagents to conduct a sequencing by synthesis protocol (SBS).
    [44]
    44. Removable cartridge, characterized by the fact that it comprises:
    a cartridge housing having a sample port that opens to an exterior of the cartridge housing and is configured to receive a biological sample;
    a rotary valve disposed in the cartridge housing,
    the rotary valve having a fluidic side and a plurality of valve ports opening on the fluidic side, the rotary valve having at least one flow channel extending between the valve ports, wherein the rotary valve is rotatable between different rotational positions;
    a microfluidic body having a body side that is slidably coupled to the fluidic side of the rotary valve, the microfluidic body at least partially defining a fluidic network that includes:
    a sample channel in flow communication with the sample port, the sample channel having a mesh port that opens to the body side of the microfluidic body;
    a reservoir configured to contain a reagent, the reservoir being in flow communication with a reservoir port that opens to the fluidic side of the microfluidic body; and a feed channel in flow communication with a fluidic network reaction chamber, the feed channel having a feed port opening to the body side of the microfluidic body; wherein the rotary valve is configured to rotate between first and second rotational positions, the mesh orifice being fluidly coupled to the feed port through the rotary valve when the rotary valve is in the first rotational position, the reservoir orifice being fluidly coupled to the orifice supply through the rotary valve when the rotary valve is in the second rotational position.
    [45]
    45. Removable cartridge according to claim 44, characterized in that the cartridge housing has an outer side that is configured to engage a base instrument, the rotary valve including a mechanical interface that is accessible on the outer side and configured to engage the base instrument.
    [46]
    46. Removable cartridge according to claim 44 or 45, characterized in that the storage module includes reagents to conduct a sequencing by synthesis protocol (SBS).
    [47]
    47. Removable cartridge according to any one of claims 44 to 46, characterized in that the rotary valve in the first rotational position is configured to receive a sample liquid when a force on the fluid moves the sample liquid towards the orifice feeding, wherein the rotary valve in the second rotational position is configured to allow the sample liquid to be displaced into the reservoir when a displacement force pushes the sample liquid away from the inlet port into the reservoir.
    [48]
    48. Removable cartridge according to any one of claims 44 to 47, characterized in that the rotary valve rotates around an axis, the feed hole being aligned with the axis.
    [49]
    49. Removable cartridge, characterized in that it comprises: a cartridge housing having a sample port that opens to an exterior of the cartridge housing and is configured to receive a biological sample, the cartridge housing including a mated side configured to face to and detachably attach to a base instrument; a fluidic network disposed in the housing, the fluidic network including a sample channel that is in flow communication with the sample port; a channel valve including a bending element configured to move between first and second positions, the bending element blocking flow through the sample channel when in the first position and allowing flow through the sample channel when in the second position, wherein the side married to the cartridge housing includes an access opening exposing the channel valve to the exterior of the cartridge housing, the access opening configured to receive a base instrument valve actuator for moving the flexure member between first and second positions.
    [50]
    50. Removable cartridge according to claim 49, characterized in that the flexing element comprises a flexible layer covering an interior cavity of the fluidic network, the flexible layer configured to be pushed into the cavity to block flow through the same.
    [51]
    51. Removable cartridge according to claim 49 or 50, characterized in that it further comprises a rotary valve disposed inside the cartridge housing, the rotary valve configured to rotate between different positions to change a flow path of the fluidic network, the rotary valve including a mechanical interface that is operatively accessible along a mated side.
    [52]
    52. Removable cartridge according to any one of claims 49 to 51, characterized in that the fluidic network includes a network hole in flow communication with the sample channel, a feed hole in flow communication with a chamber reaction, and a reservoir port in flow communication with a reservoir that is configured to store a reagent, the removable cartridge further comprising a rotary valve disposed within the cartridge housing, the rotary valve fluidly coupling the feed port and the mesh orifice when in a first rotational position and fluidly coupling the feed orifice and reservoir orifice when in a second rotational position.
    [53]
    53. Removable cartridge according to any one of claims 49 to 52, characterized in that the mated side is a first mated side and the removable cartridge includes a second mated side, the first and second mated sides facing in opposite directions, the second mated side configured to engage the instrument mechanically, fluidly or thermally.
    [54]
    54. A base instrument characterized in that it comprises: a system housing having a control side configured to engage a removable cartridge; a rotation motor configured to engage a rotating valve of the removable cartridge; a valve actuator configured to engage a removable cartridge channel valve; a set of electrical contacts configured to electrically engage the removable cartridge; and a system controller configured to control the rotation motor and valve driver to run a test protocol within the removable cartridge, the system controller configured to receive imaging data from the removable cartridge through the set of electrical contacts .
    [55]
    55. Basic instrument according to claim 54, characterized in that it further comprises a thermal block to heat a portion of the removable cartridge.
    [56]
    56. Removable cartridge characterized in that it comprises: a cartridge housing having a sample port that opens to an exterior of the cartridge housing and is configured to receive a biological sample, the cartridge housing including a mated side configured to face toward and detachably attaching to a base instrument; a microfluidic body disposed within the cartridge housing, the microfluidic body having a body side and including a fluidic network comprising a plurality of discrete channels and corresponding holes opening on the body side in a valve receiving area; and a rotary valve disposed within the cartridge housing, the rotary valve having a fluidic side and at least one flow channel extending between a plurality of valve ports, the valve ports opening to the fluidic side, the fluidic side being rotatably coupled to the valve receiving area on the body side, where the rotary valve is movable between different rotational positions to fluidly couple the discrete channels, where the rotary valve has a mechanical interface that is accessible along the mated side and configured to engage the base instrument so that the rotary valve is controlled by the base instrument.
    [57]
    57. Removable cartridge according to claim 56, characterized in that the rotary valve rotates about a shaft and the valve holes include a feed hole, the shaft extending through the feed hole.
    [58]
    58. Removable cartridge, characterized in that it comprises: a cartridge housing having a sample port that opens to an exterior of the cartridge housing and is configured to receive a biological sample, the cartridge housing having a mated side that is configured to detachably attach to a base instrument; a microfluidic structure disposed within the cartridge housing and comprising a plurality of stacked printed circuit board (PCB) layers, the PCB layers including fluidic layers defining channels, and a reaction chamber when the PCB layers are stacked, the PCB layers also including a layer of wiring; an imager configured to be mounted on the microfluidic structure and electrically coupled to the conductive wiring layer, the imager oriented to detect designated reactions within the reaction chamber.
    [59]
    59. Removable cartridge according to claim 58, characterized in that it further comprises input/output (I/O) contacts that are exposed to an exterior of the cartridge housing, the I/O contacts being electrically coupled to the imager.
    [60]
    60. Removable cartridge according to claim 58 or 59, characterized in that the microfluidic structure includes a channel valve in which at least a portion of the channel valve is defined by the PCB layers, the channel valve configured to be triggered to block and allow flow through one of the channels.
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    法律状态:
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    2022-01-25| B07A| Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]|
    优先权:
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    US201462003264P| true| 2014-05-27|2014-05-27|
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