• 专利附录
  • 专利说明
  • 权利要求
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    • 专利摘要:
    ARTICLE FOR TREATING WOUNDS WITH SUPERABSORBENT FIBERS AND SUPERABSORBENT PARTICLES. The invention relates to an article for treating wounds that contains at least one flat layer of a fabric or a nonwoven, which has superabsorbent fibers and superabsorbent particles.
    公开号:BR112016002821B1
    申请号:R112016002821-0
    申请日:2014-08-12
    公开日:2020-10-27
    发明作者:Birgit Riesinger
    申请人:Bsn Medical Gmbh；
    IPC主号:
    专利说明:

    [001] The present invention relates to wound care articles with superabsorbent fibers and superabsorbent particles.
    [002] Wound treatment articles with superabsorbent polymers are known, for example, from EP 1507498 and their usefulness has been confirmed in the treatment of chronic and intensely exudative wounds. These wound care articles contain particles of superabsorbent polymers in a cellulose matrix.
    [003] In certain areas and for certain indications the relatively low weight fraction of their superabsorbent polymer (although in certain cases exceeding 60% by weight) can be disadvantageous.
    [004] Ordinary compresses also show a certain stiffness and poor flexibility, which is disadvantageous, for example, for deep wounds, given that contact with the wound surface is not always achieved. This stiffness is often conditioned by the high thickness of these compresses or their internal layers.
    [005] Likewise, in conventional compresses, in certain circumstances the absorbed fluid can be distributed horizontally with the risk of maceration of the wound edge.
    [006] The purpose of the invention is to present an article for treating wounds that does not have these disadvantages.
    [007] This objective is achieved with the characteristics described in the main claim.
    [008] The object of the invention consists of an article for treating wounds with at least one flat layer of a fabric or a non-woven having • Superabsorbent fibers and • Superabsorbent particles
    [009] The concept of "article for treating wounds" will henceforth designate a compress, preferably a flat compress or a non-woven one. The referred compresses contain a flat layer and can be absorbent or non-absorbent or even with negligible absorption capacity. In particular, the concept of "article for treating wounds" can also designate a set of various products that can be applied in a certain order on the wound to be treated. This set can constitute a physical unit in which several products are combined in a common wrapper or, possibly without wrapper, joined with an adhesive. The set can, however, also be in the form of a kit, in which the different products are applied with the help of a roller in the order indicated on the wound to be treated.
    [010] The “non-woven” concept designates a flat textile structure made of various fibers that, unlike fabrics and knits, was not made from yarn. Nonwovens retain their structural integrity, usually through the adhesion of individual fibers to each other. They are also called “Nonwoven” and are made, for example, by fiber flooring. The “Airlaid” concept designates a special type of non-woven fabric based on cellulose and polyolefin fibers, in which superabsorbent polymers are incorporated.
    [011] The "Exudate" concept refers to fluids derived from blood plasma produced through an inflammatory process. Just as blood is responsible for the transport of nutrients and neurotransmitters, thus being responsible for supplying various parts of the body, exudates work in a similar way to supply the wound bed and the resulting healing process. To fulfill the requirements of these numerous functions, it contains a wide range of components which results in a specific weight slightly above that of water. It is distinguished from the transudate, which is derived from non-inflammatory processes and has a significantly lower specific weight, with a lower content of cells and proteins. Together with the availability of nutrients for fibroblasts and epithelial cells, the composition of the exudate influences the various healing processes in temporal and spatial terms through its high content of growth factors and cytokines. These are made up especially of thrombocytes, keratinocytes, macrophages and fibroblasts. They influence the mobility, migration and proliferation of the various cells involved in healing. In this way, cell migration in the wound bed is also promoted, as well as the supply of newly formed granulation tissue, through angiogenesis. The exudate also promotes wound cleansing. It contains several serine proteases, cysteine proteases and aspartate proteases, as well as matrix metalloproteases with highly regulated tissue-decomposing activity and thus prepare the wound bed for the next stages of healing. In general, these processes distinguish between physiological and pathological exudates.
    [012] The components of the physiological exudate are especially salts, glucose, cytokines and growth factors, plasma proteins, proteases (in particular matrix metalloproteases), granulocytes and macrophages.
    [013] Through the characteristics of the fibers, the wound treatment article according to the present invention combines the properties of three different categories of wound treatment articles currently on the market. • It has an absorption capacity similar to wound treatment products with a cellulose non-woven Airlaid layer with incorporated superabsorbent particles (example: “sorbion Sachet” product from Sorbion GmbH & Co KG) and is therefore suitable for intensively exuding wounds as well as for wounds caused by deep edema. • It has a degree of superficial humidity and protection similar to foam dressings (example: product "Allevyn Adhesive Foam" by Smith & Nephew), thus presenting a lesser tendency to dry the wound as well as a high level and comfort for the patient. in particular, the fluffy structure of the fiber, involving a lot of air, is responsible for the smoothness. • It also presents, as a union of carboxymethylcellulose fibers (“Hydrofaser", Example: product “Aquacel" by ConvaTec), a vertical absorption of fluids together with a very reduced lateral distribution of fluids, in order to (i) prevent the maceration of the wound edges and (ii) the article be able to adapt to the wound contour (“Macrocontouring”)
    [014] Such a product, with an article for treating wounds according to the present invention, is on sale, for example with the designation "sorbion soft".
    [015] Preferably, the superabsorbent fibers are expected to have a crosslinked polymer made of at least one of the following monomers • acrylic acid or acrylate (“AA”), partially neutralized with sodium salt (“AA-Na"), • methacrylate or methacrylic acid ("MA"), as well as • special acrylate / methacrylate monomer ("SAMM")
    [016] the cross-links between the individual polymer chains being constituted as ester bonds between the acid groups of acrylic acid or methacrylate and the partial sodium salt.
    [017] The general structural formulas are as follows:
    [018]

    [019] These include:
    [020] AA CH2CH (COOH) -
    [021] MA CH2CH (COOCH3) -
    [022] AANa CH2CH (COOCNA) -
    [023] R COOCH2CH (CH3) -
    [024] The acrylate / methacrylate monomer ("SAMM") is preferably a monomer selected from the group consisting of • hexapropylene glycol monomethacrylate • 2-hydroxyethyl (meth) acrylate • polyethylene glycol monomethacrylate • glycidyl methacrylate • hydroxyethyl etheryl ether and / or • hydroxyethyl methacrylate
    [025] Among these substances, hexapropylene glycol monomethacrylate is especially preferred.
    [026] The W, X, Y and Z values define the proportions of the starting materials, while the U and V values depend on the temperature and the preparation process.
    [027] Preferably, the quantitative composition can be as follows (values in mole%)

    [028] The mentioned fibers can be made of Airlaid with the other mentioned fibers. The "Airlaid" concept designates a special non-woven fabric, in which superabsorbent polymers are eventually incorporated. In this context, the following technologies known to experts are preferably used: • MBAL = Multi-Bonded Air-Laid • BBAL / LBAL = Binder-Bonded Air-Laid / Latex-Bonded Air-Laid • HBAL / XBAL = Hydrogen-Bonded Air-Laid / X-Bonded Air-Laid • Spun bound processor • Wet process
    [029] "Superabsorbent particles" (PSA) are synthetic materials capable of absorbing their weight in fluids several times - up to 1000 times. In chemical terms, it is a copolymer of acrylic acid (C3H4O2 propenoic acid) and sodium acrylate (sodium salt of acrylic acid, NaCsHsCb), where the proportion of the two monomers to each other may vary. In addition, a core crosslinker (Core-Cross-Linker CXL) is added to the monomeric solution that binds ("reticulates") the long chain polymer molecules formed with each other through chemical bonds. Through these bridges the polymer becomes insoluble in water. The penetration of water or aqueous saline solutions in the polymer particles causes the material to expand and increase the tension of this reticulate at the molecular level, so that water can no longer escape without help.
    [030] Alternatively, superabsorbents based on methylacrylic acid, copolymers of polyvinyl alcohol-maleic acid anhydride, copolymers of polysaccharides-maleic acid anhydride, maleic acid derivatives, copolymers of acrylamidepropanesulfonic acid polymers of graft amide polymers -acrylonitrile, gelled starch derivatives, alkylcellulose or hydroxyalkylcellulose, carboxymethylcellulose, acrylic starch-graft polymers, vinyl acetate-acrylic acid copolymers, acrylonitrile or acrylamide copolymers.
    [031] Superabsorbent particles can be in the form of powder or granules, with a particle size between 100 and about 1000 pm.
    [032] Likewise, said superabsorbent polymers can also be hydroxy terminated methacrylate monomers containing hydrogel nanoparticles, such as 2-hydroxyethylmethacrylate (HEMA) and / or 2-hydroxypropylmethacrylate (HPMA), p. ex. sold under the name Altrazeal.
    [033] This wound care article so prepared has numerous advantages.
    [034] The combination of the different superabsorbent materials allows a quick absorption of fluids without the horizontal distribution of the fluid in the width direction. Thus, on the one hand, as with carboxymethylcellulose, a contact surface is generated with the gel wound which, in certain circumstances, exerts a cooling effect and creates a means that promotes healing through the permanence of horizontal spread, but simultaneously prevents contact of the edges of the wound with moisture, thus also preventing maceration of the edges of the wound.
    [035] In addition, the treatment article according to the present invention, without the need for additional treatment stages, is already very smooth and malleable and is pleasant to the touch, having been perceived subjectively by patients as pleasant, but it has objectively great advantages, since it prevents aggressions during the dressing change, allows adaptation to the wound contour and simultaneously reduces the patients' pain sensation. In addition, it has damping properties that are especially advantageous in case of compression therapy or vacuum application. In addition, the wound treatment article can thus also fill in tissue gaps or substance defects ("wound contact surface") and it can be predicted in such a case that the wound treatment article will not overlap to the edge of the wound.
    [036] In particular, adaptation to the wound contour is especially advantageous, because in this way it can be ensured that the article for treating wounds can be in direct contact with the wound and the exudate existing therein. Thus, it provides a quick absorption and removal of the exudate.
    [037] In addition, the wound treatment article according to the present invention has strongly antimicrobial properties promoted, on the one hand, by the ability of the superabsorbent to bind proteins and bacteria and, on the other hand, due to the hydrophilic properties that keep bacteria away the fluids necessary for their activity.
    [038] In addition, the product maintains after the absorption of a large amount of exudate its structural integrity, and can be removed from the wound in its entirety.
    [039] In addition, it was possible to demonstrate that the combination of different superabsorbent materials allows a modulation of pro-inflammatory factors, such as matrix metalloproteinases ("MMPs"), oxygen radicals ("ROS"), ILIbeta, IL6, IL8 and Alpha TNF. This effect is also due to the binding properties of superabsorbent polymers in relation to proteins.
    [040] This product also has a surface dissolving effect. This effect refers especially to biofilms and the fibrin layer.
    [041] Due to the listed properties, wound care articles according to the present invention comprise a series of new indications. In particular, the wound treatment article according to the present invention is suitable for acute and post-surgical wounds, chronic wounds, such as wounds due to diabetes or bedsores, tumor wounds, burns, mild to severe exudative wounds, as well like deep wounds, eventually needing filling.
    [042] With special preference it is expected that the flat layer will still have • cellulose fibers and / or • bicomponent fibers
    [043] Said cellulose fibers may have the shape of said soft pulp and in addition to the damping properties they may also have hydrophilic and still structuring properties.
    [044] Two-component fibers are preferably fibers that promote thermoagglutination of the flat layer. Therefore, they preferably contain a fraction of thermoplastic polymer with an equivalent low melting point, for example of polyester, polypropylene or polyethylene that melts when heated and therefore functions as a hot adhesive (Hotmelt).
    [045] Therefore this aspect is also advantageous because in this way the mandatory pressing of the layers at high pressure, temperature and high humidity (for example by calendering) is made visible, for the conventional hydrogen bonding, as is used in the case of Airlaids without these fibers. Finally, it leads to a high compaction of the layers and thus influences the volume. The use of the mentioned fibers further increases the inclusion of air in the layers, which again promotes faster absorption of wound fluids through capillarity.
    [046] The said two-component fibers are generated preferably by coextruding two polymers with different physicochemical characteristics. Of particular interest is the "sheath / core" configuration, in which the low melting point components are located outside and the high melting point components are located inside, and the "side by side" configuration, in which both components are located. are arranged in semicircles across the fiber.

    [047] Alternatively it can be provided that the bicomponent fibers contain, together with a thermoplastic polymer, a compound consisting of at least one thermoplastic base polymer and at least one superabsorbent polymer (PSA). Preferably the melting point of the first thermoplastic is at least 20 ° C higher than the melting point of the thermoplastic contained in the compound.
    [048] The following table shows example compositions of a preferred flat layer. The ranges of values are included including the maximum and minimum numerical values of these ranges.

    [049] It can essentially be concluded that cellulose fibers absorb fluids very quickly, on the other hand they have a relatively low absorption capacity and a zero capillarity effect.
    [050] The bicomponent fibers, on the contrary, practically do not absorb fluids, on the other hand they have a high capillarity effect.
    [051] Superabsorbent fibers need some time to absorb fluids, but have a high absorption capacity. In the initial phase, they have a high capillarity effect that decreases rapidly with the beginning of the absorption process.
    [052] Through a rigorous selection of the quantitative composition of the fibers it is possible to modulate the absorption and distribution capacity of the fluids of the wound treatment article according to the present invention with the individual layers with great precision.
    [053] In this way, for example, the outer layers can be designed to have a weak capillarity effect to prevent, for example, maceration of the wound edges, while the inner layers can be prepared to present a high capillarity effect to in order to facilitate a wide distribution of fluids absorbed by the surface.
    [054] Hereinafter, the concepts "Weak capillarity effect", "medium capillarity effect" and "high capillarity effect" can be quantified as an example as "vertical wicking height [cm / h]":

    [055] The following table shows example properties of a preferred flat layer. The ranges of values are included including the maximum and minimum numerical values of these ranges.

    [056] Thus, it is preferable that the flat layer becomes thinner for the edge area, that is, assuming a thin section at the edges. In this way, a smaller load is allowed at the wound edges.
    [057] In addition, it is preferable that the flat layer, at least on one side, be covered or supported on a thin non-woven fabric. This can be, for example, a water-permeable nonwoven of polypropylene, polyethylene or polyester. Likewise, this nonwoven may be cellulose.
    [058] Essentially it can be predicted that said nonwoven, especially when it is made of a material that tends to be hydrophobic, will be treated through revival that produces a better cross-linking capacity and thus facilitates the penetration of fluids. However, this revival process is sometimes affected by the subsequent calendering process.
    [059] As the fibers are blown over the nonwoven by the Airlaid process, in the initial stage there is a situation in which some fibers penetrate the nonwoven vertically. This situation can be advantageous because these fibers facilitate the penetration of fluids in the layers, thus at least partially compensating the effect of the revival.
    [060] Mainly, in this case, the most perfect symmetry of the layered structure is preferable. If after several layers of fibers are applied in the manufacturing process, if you work with a non-woven to finish off, there is a risk that this last layer will not be crossed by the fibers vertically. • This fact can lead to the fact that the referred superior nonwoven opposes a greater resistance to the fluid than the inferior nonwoven. For these reasons, it can be expected that the upper nonwoven will be subjected to a rapid Airlaid process before being applied, in which the fibers are blown over the upper nonwoven in order to penetrate the fibers vertically, which pass through the nonwoven. , to facilitate the penetration of fluids.
    [061] The surface weight is preferably between 2-50 g / m2, preferably 5-20 g / m2, with special preference 15-18 g / m2. Such nonwoven improves the structural adhesion of the layer, especially after absorbing fluids.
    [062] Furthermore, superabsorbent fibers, cellulose fibers and / or bicomponent fibers are preferably expected to form a matrix. It is further preferred that the superabsorbent particles are incorporated in this matrix.
    [063] Furthermore, it is especially preferred that the article for treating wounds according to the present invention has a symmetrical layered structure. The symmetrical layered structure thus leads to a symmetrical cross-sectional image of the wound treatment article. This fact is very advantageous for everyday clinical practice, as caregivers can apply the article for wound treatment on the wound without worrying about the correct treatment. guidance. There is a fundamental difference here in relation to hygiene articles, such as sanitary napkins, dressings or diapers for incontinents that have an evident polarity, so that there is always a side that faces outwards and a side that faces the body.
    [064] The symmetrical layered structure is quite demanding in terms of the finishing process. Wound care articles of the aforementioned type are often made by the aforementioned Airlaid process. According to this process, the fibers used (in the present case superabsorbent fibers and possibly bicomponent fibers, as well as cellulose fibers) are blown downwards with an air current. • In this way, several sequentially connected blowing systems are normally used. The blowing process implies that the fibers applied by the second or third or even other blowing systems have a tendency to migrate downwards. In this way, there is a distribution of fibers that can affect the desired symmetry. Thus, it may be advantageous for a process to change the desired fractions of fibers in the individual blowing systems differently from the quantities actually necessary for a symmetry, in order to take into account the process of a posteriori migration of the fibers.
    [065] The article for treating wounds according to the present invention may also have a flat layer with cellulose fibers, foam, modified cellulose and / or alginate.
    [066] The term "foam" means an open or closed pore foam, preferably polyurethane.
    [067] In the case of modified cellulose, these are preferably cellulose derivatives, preferably nanocellulose, sulphonated and / or sulfoalkylated cellulose and their derivatives, preferably ethyl cellulose sulfonate, carboxyalkylated cellulose and / or carboxypropylcellulose, more complex cellulose derivatives , such as sulfoethylcarboxymethylcellulose, carboxymethylhydroxyethylcellulose, hydroxypropylmethylcellulose and amidated cellulose derivatives, such as carboxymethylcellulose-amide or carboxypropylcellulose-amide. Carboxymethylcellulose is found especially in the form of sodium carboxymethylcellulose and is sold under the name "Hydrofiber". In hygiene and wound products, these fibers are converted into a flat matrix. With the absorption of fluids from an exudate, the fibers are progressively converted into gel pads that retain fluids and do not release them. These fibers are formed in such a way that the exudate is only absorbed vertically. That is to say, the exudate does not run down the edge of the wound, as far as the capacity of the fibers is concerned. In this way it is possible to effectively avoid wound maceration. • In the present context, chitin, chitosan and their derivatives are also covered by the designation of cellulose derivatives.
    [068] Alginates are obtained from brown and interlaced algae, forming a fibrous blanket. In chemical terms, these are polysaccharides and even calcium and / or potassium salts of alginic acid. Alginates can absorb up to 20 times their weight in fluids, retaining exudate in hollow spaces. The Ca2 + ions contained in the alginate lattice are exchanged for the Na + ions in the exudate until the degree of Na ion saturation in the alginate is reached. There is then a swelling on the wound surface and a conversion of the alginate fibers into a gel upon expansion of the fibers.
    [069] Furthermore, it is preferable that the article for treating wounds has a capsule made at least partially of a liquid-permeable material. This capsule has multiple functions. It can prevent the adherence of the article to treat wounds to the wound itself, prevent a backward exudate to the wound, have a hypoallergenic function and prevent wound maceration. The capsule is preferably at least partially closed with a seam, for example collage seam or an ultrasonic seam and can be made of either a sheet or a film (for example PE) or even a non-woven ( for example PP) or non-woven.
    [070] In particular, it may be envisaged that the capsule will have pores that are on average lower than the superabsorbent particles. In this way, particles can escape from the capsule. This last aspect can particularly affect the sterilization process, namely when the particles reach the area of the sealing barrier and affect the tightness.
    [071] The capsule can also be coated with a heavy metal in the form of an element or ion or be covered with, for example, silver, zinc or copper.
    [072] The capsule can also be coated with a material that binds bacteria through hydrophobic interactions, such as dialkyl carbamoyl chloride (short for English, DACC).
    [073] The size of the pores, however, affects the speed of passage of the exudate to be absorbed. This phenomenon occurs especially with more or less hydrophobic polymeric materials. Through an adequate revival treatment, the capsule's crosslinking capacity can be improved in general and therefore ensures the absorption speed, even with small pores.
    [074] The pores or meshes of the capsule are preferably from 0.05 mm to 1.0 mm, preferably from 0.20 mm to 0.50 mm. Furthermore, it is preferable to project that the pores or meshes are limited by sections of yarn or fibers with a slightly arched section due to the capsule and with the vertices of the arches facing outward.
    [075] Preferably, the flat layer (i) has a surface (F1) in a superior perspective on the flat side, which when cross-linked is 3% to 75% smaller than the surface (F2) of the open internal space by the capsule, and / or (ii) the capsule has at least in some sections an elastic material.
    [076] In the first case, the aforementioned expansion space provides the flat layer capsule. In both cases, care is taken to avoid the formation of pressure due to the increase in volume of the flat layer, motivated by the absorption of fluids with the presence of the capsule, so that this flat layer can reach its maximum absorption capacity. The elastic material may have, for example, lycra, elastane, polypropylene, rubber, latex or the like.
    [077] Furthermore, it is preferentially provided that the capsule is made at least partially from a three-dimensional wound-separating mesh or that it is covered over or under by a mesh like this. Said wound separator net is preferably a net made of polyethylene film by blowing, as described, for example in EP2004116A1. In the same way it can be, for example, a silicone net.
    [078] Such a network also has multiple functions. Depending on the shape of the pores, it can act as a valve and thus prevent the exudate from escaping (preferably in the case of funnel-shaped or conical pores). It can prevent the adherence of the article for treating wounds to the wound itself (preferably with the use of a silicone material). With an appropriate arrangement it is possible to create abrasive properties and thus remove the biofilm from the wound or prevent its formation (preferably in the case of funnel-shaped or conical pores). It may also present hemostatic characteristics and eventually be able to immobilize or fix bacteria through static interactions (preferably in the case of using a polyethylene material or a material with a positive net charge). In addition, the surface can be made functional, for example with a layer of silver or silicone.
    [079] Preferably, it is also foreseen that the capsule should be made at least partially of a material impregnated or impermeable to water or that it is covered over or under by this material. In this case, it can be a colored backsheet or a special shape.
    [080] Preferably it is also envisaged that the wound treatment article has a fraction of at least one elemental or ion-shaped heavy metal. Heavy metals in fine distribution have a bactericidal effect, which thanks to the very reactive surface is due to the generation of sufficient soluble heavy metal ions.
    [081] Impregnation with at least one elemental heavy metal or in the form of an ion can give the primary dressing an antibacterial effect that prevents complications in wounds that can infect (decubitus wounds, crural venous ulcer, third degree burns, etc.). ) and can simultaneously increase the dressing time.
    [082] Preferably it is envisaged that at least one elementary or ion heavy metal is selected from the group consisting of copper, zinc and / or silver. The remaining bactericidal properties mentioned are valid especially with these three metals.
    [083] Furthermore, it is preferable that the flat layer or the capsule, on at least one side, be covered or supported by a covering film. Preferably, said covering film has at least one of the following properties: • Adhesive coating • impermeability • water vapor permeability and / or • elasticity.
    [084] In this case it is especially preferred that the covering film exceeds the periphery of the article for treating wounds and can be applied to the skin around the wound. In this way, a dressing with a central part and edge is realized.
    [085] Alternatively, the capsule itself is provided with an adhesive coating on one side. In the cases mentioned, the adhesive coating preferably has an acrylate glue, a silicone glue, a starch glue, a hydrocolloid glue and / or another suitable physiologically harmless glue.
    [086] The wound care product may also contain at least one component selected from the group consisting of • hyaluronic acid (preferably as a coating for superabsorbent polymers) • Octenidine • Dimethicone • Active carbon
    [087] In addition it is also in accordance with the present invention a) the use of a wound treatment article according to any of the claims below in a negative pressure wound treatment system and b) the use of a treatment article of wounds according to one of the claims below for the treatment of acute and post-surgical wounds, chronic wounds, wounds due to diabetes or bedsores, tumor wounds, burns, exudative wounds, mild to severe, as well as deep wounds, eventually needing filling.
    [088] In this case, use in the sacred zone is especially preferred. The nonwoven according to the present invention can be made as follows: 1. Dry spinning process
    [089] 10 dtex superabsorbent fibers, of a copolymer with the above composition, are created by dry spinning from an aqueous solution and cutting (fiber length of 6 mm), followed by crosslinking at 200 ° C until form ester bridges between the carboxylic acid groups and hydroxyl groups.
    [090] The superabsorbent fibers had an absorption of 50 g / g (measured according to the Free Swell Absorbancy Test) and a retention under load of 35 g / g.
    [091] 2. Wet process
    [092] A wet Pulp Evaluation device from Mavis Manufacturing Company, London, was used for the preparation of wet fleece. All fleeces were produced in bands of 1.2 g dry weight. The required amounts of dry cellulose (grade X rayon) were dispersed at 5000 U / min in 2 liters of water with a high shear mixer. Cellulose fibers had an absorption capacity of less than 10 g / g of retention, measured by centrifuging a 0.9% solution by weight of sodium chloride. The superabsorbent fibers were dispersed in 100 ml of water for about 2 seconds, until they expanded and then added to the dispersed cellulose fiber. The mixture was stirred with a spatula. The mixture was then added to a papermaking column and the nonwoven was molded on a 25 mesh screen. The fibers were compressed and then dried at room temperature. Thus bands were formed with the following characteristics.

    [093] Fig. 1 Shows a nonwoven according to the present invention through a scanning electron microscope. In this figure A designates the superabsorbent fibers, B the superabsorbent particles and C a buffer layer of cellulose fibers and incorporated air ("Fluff Pulp") (D).
    权利要求:
    Claims (19)
    [0001]
    1. Wound treatment article characterized by containing at least one flat layer of a fabric or a non-woven one, which features • Superabsorbent fibers and • Superabsorbent particles in which the flat layer also comprises bicomponent fibers, in which bicomponent fibers are generated by two co-extruded polymers in the sheath / core configuration or side-by-side configuration, in which the bicomponent fibers contain a fraction of a thermoplastic polymer that functions as a hot melt adhesive.
    [0002]
    Wound treatment article according to claim 1, characterized in that the superabsorbent fibers have a cross-linked polymer produced from at least one of the following monomers • acrylic acid or acrylate (“AA”) • methacrylate or methacrylic acid (“ MA ") • acrylic acid or methacrylic acid partially neutralized in sodium salt (" AANa ") and the cross-links between the individual polymer chains constituted as ester bonds between the acid groups of acrylic acid or methacrylate and the partial sodium salt .
    [0003]
    Wound treatment article according to any one of claims 1 to 2, characterized in that the flat layer also contains cellulose fibers.
    [0004]
    Wound treatment article according to any one of claims 1 to 3, characterized in that the flat layer on at least one side is covered or supported on a thin non-woven fabric.
    [0005]
    Wound treatment article according to any one of claims 1 to 4, characterized in that the superabsorbent fibers, cellulose fibers and / or bicomponent fibers form a matrix.
    [0006]
    Wound treatment article according to any one of claims 1 to 5, characterized in that the superabsorbent particles are incorporated in the fiber matrix.
    [0007]
    Wound treatment article according to any one of claims 1 to 6, characterized in that the layered structure has a symmetrical cross section.
    [0008]
    Wound treatment article according to any one of claims 1 to 7, characterized in that it also has a flat layer with cellulose fibers, foam, modified cellulose and / or alginate.
    [0009]
    Wound treatment article according to any one of claims 1 to 8, characterized in that it also has a capsule consisting at least in part of a fluid-permeable material.
    [0010]
    10. Wound covering article according to claim 8, characterized in that (1) the flat layer in a top perspective on the flat side has a surface (F1), which surface, when not yet reticulated, is 3% to 75% smaller than the surface (F2) of the internal space opened by the capsule, and / or (ii) the capsule has at least in some sections an elastic material.
    [0011]
    Wound treatment article according to claims 8 and 9, characterized in that the capsule is made at least partially from a three-dimensional wound-separating mesh or is covered over or under by a mesh like this.
    [0012]
    Wound treatment article according to claims 8 to 10, characterized in that the capsule is made at least partially of a material impregnated or impermeable to water or is covered over or under by this material.
    [0013]
    Wound treatment article according to any one of claims 1 to 12, characterized in that it has a fraction of at least one elemental or ion-shaped heavy metal.
    [0014]
    Wound treatment article according to claim 12, characterized in that at least one elemental or ion heavy metal is selected from the group consisting of copper, zinc and / or silver.
    [0015]
    Wound treatment article according to any one of claims 1 to 15, characterized in that the flat layer or the capsule is covered or supported on at least one side by a covering film.
    [0016]
    Wound treatment article according to claim 13, characterized in that the covering film exceeds the periphery of the wound treatment article and can be applied to the skin around the wound.
    [0017]
    17. Wound treatment article according to any one of claims 1 to 16, characterized in that the flat layer or the capsule has at least one side of an adhesive coating.
    [0018]
    Use of a wound treatment article according to any one of claims 1 to 17, characterized in that the use is in a negative pressure wound treatment system.
    [0019]
    19. Use of a wound treatment article according to any one of claims 1 to 18, characterized in that it is for the treatment of acute and post-surgical wounds, chronic wounds, wounds due to diabetes or bedsores, tumor wounds, burns, wounds mild to intense exudatives, as well as deep wounds, eventually needing filling.
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    US20210000653A1|2021-01-07|Wound dressing
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    同族专利:
    公开号 | 公开日
    CN105813660A|2016-07-27|
    JP2016527065A|2016-09-08|
    BR112016002821A2|2017-08-01|
    CA2921174C|2021-03-23|
    MX370332B|2019-12-10|
    AU2014307890B2|2018-04-19|
    CA2921174A1|2015-02-19|
    US20160270966A1|2016-09-22|
    AU2014307890A1|2016-03-03|
    JP6671755B2|2020-03-25|
    EP3033116A1|2016-06-22|
    US10925773B2|2021-02-23|
    WO2015022340A1|2015-02-19|
    EP3033116B1|2021-04-07|
    MX2016001565A|2016-09-07|
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    法律状态:
    2018-06-05| B25C| Requirement related to requested transfer of rights|Owner name: BSN MEDICAL GMBH (DE) |
    2018-08-28| B25A| Requested transfer of rights approved|Owner name: BSN MEDICAL HOLDING GMBH (DE) |
    2018-09-18| B25D| Requested change of name of applicant approved|Owner name: BSN MEDICAL GMBH (DE) |
    2019-08-06| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-05-12| B09A| Decision: intention to grant|
    2020-10-27| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/08/2014, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    DE102013108734.5|2013-08-12|
    DE102013108734|2013-08-12|
    DE202013104893.3|2013-10-31|
    DE201320104893|DE202013104893U1|2013-10-31|2013-10-31|Wound care articles comprising superabsorbent fibers and superabsorbent particles|
    PCT/EP2014/067282|WO2015022340A1|2013-08-12|2014-08-12|Wound care article having super-absorbent fibers and super-absorbent particles|
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