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    • 专利摘要:
    IMPROVED ALCOHOL BASED SANITIZER WITH SENSATION AND DERMAL COMPATIBILITY The invention presents a critical beneficial set for the skin that can be used in liquid alcohol based sanitizing compositions with smaller amounts of skin conditioners combined with a specific proportion of different emollients, which provide improved skin health with chronic repeated use. The set also offers improved dermal sensation without sticky residue after drying.
    公开号:BR112015030649B1
    申请号:R112015030649-7
    申请日:2014-05-10
    公开日:2020-12-01
    发明作者:Joseph R. Wegner；Cheryl A. Littau
    申请人:Ecolab Usa Inc.；
    IPC主号:
    专利说明:

    Field of invention
    [001] The invention is related to liquid compositions of alcohol-based sanitizer skins that are formulated for repeated long-term use. The compositions include a level of components to help maintain or improve skin health while maintaining an acceptable and efficient skin feel. Background of the invention
    [002] Alcoholic compositions are desirable products for skin and hand care. They are effective against a wide range of microorganisms, such as gram positive and gram negative bacteria and fungi. They are also able to eliminate microorganisms more quickly than other antimicrobial products. Alcohol-based antimicrobial products are available as aqueous liquids, gels, emulsions and aerosol foams.
    [003] Hand sanitizing substances are used to reduce the risk of exposure and dispersion of pathogenic microorganisms found in daily activities. Although the use of alcohol-based sanitizing gels and foams is well known, there is a need for a formulation that is more effective in killing germs and drying quickly, without harming the health of the skin. However, many of these quick-drying gels have a composition that releases an undesirable sticky residue. In addition, if the alcohol level is increased, such conventional gels generally dry out the skin. Thus, the need for a high percentage alcohol that does not produce an undesirable residue or dry out the skin persists.
    [004] It is well known that the health of the skin can be improved in the release of antibacterial products by the addition of humectants or moisturizers. However, the level of moisturizer needed to improve the skin generally causes product build-up and increased viscosity which is uncomfortable for the user and can also increase the difficulty of using gloves, reducing the effectiveness of the work. Aspects of viscosity and glove placement can cause reduced use of the product because the viscosity makes the worker feel that his hands are "dirty" and need to be washed, and the reduced ability to use the gloves impairs the flow of work .
    [005] When the level of skin health components in an alcohol-based sanitizer is not high enough, healthcare workers may experience extreme dryness of their hands or in more severe cases contact dermatitis, especially in climates with low humidity or during the “dry” months of the year. Generally, basic / conventional hand sanitizers do not contain adequate amounts of skin health promoting agents for continuous use.
    [006] It is the object of the present invention to offer a liquid alcohol-based sanitizing skin composition that can be in the form of a gel, liquid, emulsion or aerosol foam, providing an improved skin sensation without impairing effectiveness, and that when used repeatedly improves skin health.
    [007] Other objects of the invention will become clear from the description of the invention below. Summary of the invention
    [008] The inventors have identified a set of critical skin benefits that can be used in alcohol-based liquid sanitizing compositions that offer improved skin health with chronic repeated use. The set also offers improved skin feel without the formation of a sticky residue during drying.
    [009] According to the invention, a set of components that benefit the skin is employed including a specific combination of emollients. The invention uses a combination of “high dispersion oils” (such as tipprilyl carbonate, dibutyl adipate, hexyl laurate, tippryl ether, propylheptyl caprylate, 4-10 centistoke silicone oil (4 x 10-6 m2 / s - 10 -5 m2 / s) (, cyclic siloxane D4, D5 or D6, isocetyl palmitate, hydrogenated polyisobutene and diethylhexylcarbonate), combined with medium dispersion oils (such as capric / caprylic triglyceride, C12-15 alkyl benzoate, capric triglyceride, triglyceride caprylic, isopropyl myristate, isopropyl palmitate, octyldodecanol, decyl oleate, cocoglycerides, ethylhexyl stearate, cetearyl isononanoate, cetearyl ethylhexanonate, decyl cocoate, cetyl dimethicone, ethylhexyl palmitate, PPG-11 ether and PPG-11 ether butyl) .The ratio of oils is about 3: 1 to about 1: 3 of high dispersion oil in relation to medium dispersion oil.
    [010] The set of benefits for the skin includes conditioning agents, such as glycerin, bisabolol, vitamin E, nicatinamide, glyconic acid, glycine and the like. These agents are present in an amount of less than 1.0% by weight, preferably less than 0.8% by weight each, and more preferably less than 0.5% by weight each and all conditioning agents. of the skin together comprise less than 3% by weight of the sanitizing composition, preferably less than 2% by weight, and more preferably less than 1% by weight.
    [011] The liquid sanitizing product based on alcohol can be in the form of an aqueous liquid, gel, emulsion or foam (aerosol or not). In a preferred embodiment, the product is in the form of a non-aerosol foam sanitizer.
    [012] In addition to the set of benefits for the skin, the composition includes a sanitizing component of a simple or branched lower alcohol, such as a C1-6 alcohol, or a mixture of two or more of this alcohol. The alcohol is present in an effective amount, generally from about 40% to about 99% by weight of active alcohol, preferably from about 50 to about 90% by weight and most preferably from about 60 to about 80% by weight. Examples of suitable alcohols include ethanol, propanols, such as isopropanol and n-propanol and butanols.
    [013] The composition may also include other components, such as other skin conditioners, emollients, moisturizers, humectants, thickeners, surfactants, fragrances, water and the like. a.The invention also includes a method of sanitizing the skin by applying the sanitizer to the skin and letting it dry. The method is particularly designed for multiple uses, such as in the healthcare field, where professionals can apply the composition several times a day. The method includes the use of a composition that contains a smaller amount of skin health materials applied several times a day (chronic dose), and has similar effects to higher levels applied once or twice a day (acute dose).
    [014] These and other modalities will become clear to those skilled in the field and others through the detailed description below of some modalities. However, it should be understood that this summary and the detailed description illustrate only a few examples of various modalities and are not intended to limit the invention. Detailed description of the figures
    [015] Figure 1 is a graph of the total acceptance of the product by nurses comparing a sanitizer of the invention with a commercially available product formulated to improve skin health with higher levels of moisturizers. It can be seen that the composition of the invention showed a statistically significant increase in the total acceptance of the product in relation to the commercial product with higher levels of moisturizers.
    [016] Figure 2 is a graph showing the ease of use of gloves from the same test as in Figure 1. Again, from the results, it can be seen that the composition of the invention resulted in greater ease of use of gloves than the product available commercially with high levels of moisturizers.
    [017] Figure 3 is a graph of the controlled application test on the forearm (FCAT) demonstrating changes in visual dryness for the two compositions of the invention and for the nutritional formula of commercially available skin, as well as untreated skin. From the results, it was observed that the products were similar with respect to the change in visual dryness, however the compositions of the invention had the lowest levels of skin conditioning components.
    [018] Figure 4 is a graph of FACT results showing alteration X the reference base for visual redness. Again, all products were statistically similar, but the compositions of the invention had fewer skin conditioning components.
    [019] Figure 5 is a graph of the results of the corneometer (skin hydration) of the controlled application test on the forearm. The results showed that the compositions of the invention did not have any detrimental effect on skin hydration.
    [020] Figure 6 is a graph of the results of the loss of transepid skin water (TEWL) from the controlled application test on the forearm. The results showed that one of the compositions of the invention showed statistically different loss of water from the skin.
    [021] Figure 7 is a graph of the results of a controlled application test on the leg (LCAT) showing visual dryness as determined by a specialist. It can be seen that the product of the invention, even when used with 30 applications per day, was the most similar to untreated skin, while both commercial conventional sanitizers with 30 applications per day and antibacterial soap only 3 times a day showed a significant increase in dryness compared to untreated skin.
    [022] Figure 8 is a graph of the results of the controlled application test on the leg showing dryness measured with a corneometer (skin hydration by capacitance). Again the results showed that the composition of the invention had a higher hydration content than skin treated with both commercial compositions. Detailed description of the invention
    [023] Although the technology of the invention is described together with one or more modalities of preference, it must be understood by those skilled in the field that is not limited to these particular modalities only. On the contrary, the present technology includes all alternatives, modifications and equivalents as they may be included within the spirit and scope of the attached claims.
    [024] It should be noted that, as used in this specification and in the claims, the singular forms "one", "one", and "a / o" encompass the plural equivalents unless clearly indicated to the contrary. Therefore, for example, in relation to a composition containing "a compound" it includes a mixture of two or more compounds. It should also be noted that the term "or" is generally used in its sense, including "and / or" unless clearly indicated to the contrary.
    [025] The term "assets" or "percentage of assets" or "percentage by weight of assets" or "concentration of assets" are used interchangeably in the present invention and refer to the concentration of these involved components expressed as a percentage minus the inert components , such as water or salts.
    [026] As used in the present invention, "weight percentage", "weight%", "weight percentage" and its variations refer to the concentration of a substance as its weight divided by the total weight of the composition and multiplied by 100 It should be understood that as used in the present invention, "percentage", "%" and the like are synonymous for "percentage by weight" "% by weight", etc.
    [027] The term "about", as used in the present invention, modifying the amount of a component in the compositions of the invention or employed in the methods of the invention refers to the variation in the numerical quantity that can occur, for example, through common measurement and liquid handling procedures used to produce concentrates or solutions for use; through accidental error in these procedures; through differences in the production, source, or purity of the components employed in producing the compositions or carrying out the methods; and the like. The term also covers amounts that differ due to different equilibrium conditions for a composition resulting from a particular initial blend. Modified or not by the term "about", the claim includes equivalents for the quantities. All numerical values can be modified in the present invention by the term "about", clearly indicated or not. The term “about” generally refers to a range of numbers that a person skilled in the field can consider equivalent to the value described (that is, presenting the same function or result). For example, the term "about" may include numbers that are approximated to a more significant value.
    [028] The term "alkyl" or "alkyl groups", as used in the present invention, refers to saturated hydrocarbons having one or more carbon atoms, including single-chain alkyl groups (for example, methyl, ethyl, propyl, butyl , pentila, hexila, heptila, octila, nonila, decila, etc.), cyclic alkyl groups (or "cycloalkyl" or "alicyclic" or "carbocyclic") (for example, cyclopropyl, cyclopentyl, cyclohexyl, cycloeptyl, cyclooctyl, etc. ), branched chain alkyl groups (e.g., isopropyl, tert-butyl, sec-butyl, isobutyl, etc.) and substituted alkyl groups (e.g., substituted cycloalkyl alkyl groups and substituted cycloalkyl alkyl groups).
    [029] Unless otherwise specified, the term "alkyl" includes both "unsubstituted alkyls" and "substituted alkyls". As used in the present invention, the term "substituted alkyls" refers to alkyl groups having substituents for one or more hydrogens on one or more carbons of the hydrocarbon structure. Such substituents may include, for example, alkenyl, alkynyl, halogen, hydroxyl, alkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aryloxy, aryloxycarbonyloxy, carboxylate, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonyl, alkylcarbonyl, alkylcarbonyl, alkylcarbonyl, alkylcarbonyl, alkylcarbonyl, alkylcarbonyl, alkylcarbonyl, alkylcarbonyl, alkylcarbonyl, alkylcarbonyl, alkylcarbonyl. cyano, amino (including alkyl amino, dialkylamino ,, arylamino, diarylamino and alkylarylamino), acylamino (including alkylcarbonylamino, arylcarbonylamino, carbamoyl and ureido), imino, sulfhydryl, alkylthio, arylthio, thiocarboxylate, sulfates, alkylsulfinyl, sulfonates, sulfonates nitro, trifluoromethyl, cyano, azido, heterocyclic, alkylaryl, or aromatic groups (including heteroaromatics). In some embodiments, substituted alkyls may include a heterocyclic group. As used in the present invention, the term "heterocyclic group" includes closed ring structures analogous to carbocyclic groups where one or more carbon atoms in the ring is an element other than carbon, for example, nitrogen, sulfur or oxygen. Heterocyclic groups can be saturated or unsaturated. Examples of heterocyclic groups include, but are not limited to, aziridine, ethylene oxide (epoxides, oxiranes), thyrane (episulfides), dioxirane, azetidine, oxethane, tiethane, dioxetane, dithietane, azolidine, pyrrolidine, pyrrolidine, pyrroline, oxolane, dihydrofuran and furan.
    [030] The differentiation of “bactericidal” or “bacteriostatic” antimicrobial activity, whose definitions describe the degree of effectiveness and official laboratory protocols for measuring this effectiveness, are considerations for understanding the relevance of agents and antimicrobial compositions. Antimicrobial compositions can cause two types of microbial cell damage. The first is an irreversible, lethal action that causes the destruction or complete incapacitation of the microbial cell. The second type of cell damage is reversible, where if the microorganism is no longer under the influence of the agent, it can be multiplied again. The former is called bactericidal and the latter bacteriostatic.
    [031] The term "sanitizer", as used in the present invention, refers to an agent that reduces the number of bacterial contaminants to ensure levels in accordance with public health requirements. The reading of the numerical ranges by periods includes all numbers included within this range (for example, 1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4 and 5).
    [032] The terms "includes" and "including" refer to a list of materials, but are not limited to the materials listed.
    [033] Skin health can be improved by adding moisturizers or moisturizers to antibacterial products. However, the level of moisturizer needed to improve skin health generally causes product build-up and excess viscosity, which is unpleasant for the user, making it difficult to use gloves, reducing efficiency at work. Both the viscosity and the difficulty of using the gloves can cause reduced use of the product by health professionals because the viscosity makes them feel that their hands are "dirty" and need to be washed, and the reduced ability to use the gloves prevents the flow of work.
    [034] When the level of skin health components in an alcohol-based sanitizer is not sufficient, healthcare professionals may experience extreme dryness in the hands and in more severe cases, contact dermatitis, especially in climates with low temperatures. humidity or during the “dry” months of the year. Basic / conventional hand sanitizers do not contain adequate amounts of skin health promoting agents with repeated use. There are limited data regarding the low-dose application of skin health components, such as niacinamide, ceramides, vitamin E, vitamin K, vitamin D, amino acids (including glycine and proline), applied multiple times a day to reach the same levels obtained in one or two doses in published clinical studies that have been shown to improve health with these components. Since healthcare professionals use products (usually in the form of hand sanitizers) with 20 to 100 applications / day, with periodic washing during the day, they do not fit the model of one or two doses with a higher active level for day. According to the invention, smaller doses of skin care materials applied multiple times a day (chronic) in the correct proportions can have similar effects to larger doses applied once or twice a day (acute).
    [035] Although skin health is one side of the product acceptance equation, the other side is the sensation caused by the product. If the product is considered sticky or accumulates, it will not be well accepted by healthcare professionals.
    [036] As previously indicated, the inventors have identified a set of benefits for the skin that can be used in liquid alcohol-based sanitizing compositions that offer improved skin health with chronic repeated use. The set also offers improved skin feeling without a sticky residue during drying.
    [037] The alcohol-based liquid sanitizing product can be in the form of an aqueous liquid, emulsion gel or foam (aerosol or not). In a preferred embodiment, the product is in the form of a non-aerosol foam cleaner. Compositions of the invention
    [038] The compositions of the invention include a set of benefits for the skin with a specific ratio of emollients from about 3: 1 to about 1: 3 of a high dispersion oil to a medium dispersion oil, offering the best sensation in the skin without a sticky residue and with a smaller amount of skin conditioning agents (less than 3% by weight), providing skin health due to the chronic repeated use of such compositions. The range of skin benefits can be added to conventional sanitizing compositions, preferably those that are alcohol based. Therefore, the composition includes a sanitizing component preferably of a simple or branched lower alcohol, such as a C1-6 alcohol or a mixture of two or more of such alcohols. The sanitizing component is present in an effective amount, generally from about 40% to about 99% by weight of active alcohol, preferably from about 50 to about 90% by weight, and most preferably from about 60 to about 80% by weight.
    [039] The alcohol-based liquid sanitizing product can be in the form of an aqueous liquid, gel, emulsion, aerosol or non-aerosol foam. In a preferred embodiment, the product is in the form of a non-aerosol foam.
    [040] Alcohol
    [041] The sanitizing component may include an effective amount of a simple or branched lower alcohol. In some embodiments, the alcohol is a lower alkanol, that is, an alcohol containing 1 to 6 carbon atoms. These alcohols generally have antimicrobial properties. Examples of lower alkanols include, but are not limited to, methanol, ethanol, propanol, butanol, pentanol, hexanol and isomers and mixtures thereof. In one embodiment, the alcohol comprises ethanol, propanol or butanol, or isomers or mixtures thereof. In another embodiment, alcohol comprises ethanol.
    [042] Generally, the composition comprises an alcohol sanitizing component of at least about 30% by weight. In certain embodiments, the antimicrobial composition comprises from about 40% by weight to about 99% by weight of alcohol, and in other embodiments, the composition comprises from about 40% by weight to about 95% by weight of alcohol, and in other embodiments, the composition comprises from about 60% by weight to about 80% by weight of alcohol, based on the total weight of the antimicrobial composition.
    [043] Set of benefits for the skin
    [044] The invention includes a set of benefits for the skin to be used with sanitizing alcohol. According to the invention, the set of benefits for the skin is employed including a specific combination of emollients based on their dispersion characteristics as well as skin conditioners. For the purpose of the invention, emollients that modify the sensation on the skin are characterized in three groups with high dispersion, medium dispersion and low dispersion. The dispersion value of the emollients for the purpose of the invention is determined by measuring the area covered by a fixed amount of oil over a given period of time, and is related to a combination of viscosity, polarity and molecular weight. The preferred measurement method is the one used by Cognis, measuring mm2 / 10 minutes.
    [045] High dispersion emollients are present in an amount of about 0 to about 2% by weight, preferably about 0 to about 2% by weight and most preferably from about 0 to about 1% by weight. Weight. Medium dispersion emollients are present in an amount from about 0 to about 3% by weight, preferably from about 0 to about 2% by weight and most preferably from about 0 to about 1% by weight. Low dispersion emollients are present in an amount of about 0 to about 5% by weight, preferably from about 0 to about 4% by weight and even more preferably from about 0 to about 3% by weight .
    [046] The inventors have found that the critical aspect of the invention is that the ratio of high dispersion to medium dispersion oil of about 3: 1 to about 1: 3 offers the best skin feel without a sticky residue. High dispersion emollients
    [047] Emollients include materials with dispersion values> 1000 mm2 / 10 min. These materials also include polymers such as dimethyl siloxanes with viscosities less than 10 centistokes (cst) (10-5 m2 / s). Examples of high dispersion oils include, but are not limited to dicasprilyl carbonate, dibutyl adipate, hexyl laurate, tippryl ether, propylheptyl caprylate, 4-10 centistoke silicone oil (4x10-6 m2 / s - 10-5 m2 / s ), cyclic siloxane D4, 5 or 6, isocetyl palmitate, hydrogenated polyisobutene and diethylhexyl carbonate. Medium dispersion emollients
    [048] These include materials with dispersion values> 500 mm2 / 10 min and <151000 mm2 / 10 min. These materials can also include polymers, such as dimethylsiloxanes with viscosities between 10 cst (10-5 m2 / s) and 100 cst (10-4 m2 / s). Examples of medium dispersion oils include, but are not limited to, capric / caprylic triglyceride, C12-15 alkyl benzoate, capric trigleride, caprylic triglyceride, isopropyl myristate, isopropyl palmitate, octyldodecanol, decyl oleate, cocoglycerides, ethylhexyl stearate, cetane and cetane, cetane, ketone, ketone ethylhexanonate, decyl cocoate, cetyl dimethicone, ethylhexyl palmitate, PPG-11 stearyl ether, PPG-15 stearyl ether, dimethicone fluid (10-20 csr - 10-5 m2 / s-2x10- 5 m2 / s), and PPG ether -14 butyl. Low dispersion emollients
    [049] These include dispersion values <500 mm2 / 10 min and any oily or paraffin material with a melting point greater than 20 ° C. These materials can also include polymers, such as siloxanes with viscosities greater than 100 cst (10-4 m2 / s). Low dispersion emollients include mono-, di- and triglycerides and butters and hydrogenated versions of seeds and nut oils including, but not limited to, palm oil, coconut oil, vegetable oil, avocado oil, canola oil, corn, soybean oil, sunflower oil, safflower oil, limnant seed oil, blueberry seed oil, watermelon seed oil, olive oil, blueberry oil, macadamia nut oil, argan oil, moroccan argan oil, blueberry oil, raspberry oil, walnut oil, pecan oil, peanut oil, bayberry oil, mango seed oil, castor oil, shea butter, oil jojoba oil, hydrolyzed jojoba oil, carnauba butter, carnauba wax, heptanoate stearyl succinate castor isostearate, cetyl ricinoleate, oleyl frucate, sucrose monostearate, sucrose distearate, sucrose tristrate, sucrose, tetraesterate soybean, rapeseed wax, palm wax, wax bee, petrolatum, myristyl myristate, oleyl eluate, squalene, stearyl alcohol, cetearyl isononanoate, polyisobutene, glyceryl stearate, glyceryl distearate, cetyl alcohol, lanolin, lanolin ethoxylate, low molecular weight polyethylene waxes, polypropylene waxes low molecular weight, glyceryl PEG-30 cocoate, glyceryl PEG-80 cocoate, glyceryl PEG-30 stearate, PEG-8 ricinoleate, PEG-8 raspberriate, linear versions (also known as bis) and pending hydroxyl terminations and methyl ether; PEG-3 to PEG32 dimethicone (including but not limited to PEG-3 dimethicone, PEG-8 dimethicone, PEG-9 dimethicone, PEG-10 dimethicone, PEG-11 methyl ether dimethicone, PEG-12 dimethicone, PEG-14 dimethicone, PEG -17 dimethicone, PEG-32 dimethicone), bis-PEG / PPG-20/20 dimethicone, PEG / PPG 20/23 dimethicone, PEG / PPG 20/22 butyl ether dimethicone, PEG / PPG 20/23 dimethicone, PEG / PPG 20/22 dimethyl butyl ether, PEG / PPG 23/6 dimethicone, PEG / PPG 20/15 dimethicone.
    [050] Modified alkyl dimethicone (stearoxy dimethicone, beenoxy dimethicone, cetyl dimethicone, certeryl methicone, C30-45 alkyl copolymer cetearyl dimethicone, C30-45 alkyl dimethicone, caprylyl methicone, dimeroletic acid dimer copolymer, PEG-8 dimer dilinoleate / bis-PEG-10 dimethicone, copolymer dimethicone / stearoxymethyl, difeyl dimethicone, lauryl polyglycerol-3 polydimethylsiloxyethyl dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone), dimethicone fluid (> 20 cst - 2) x 10 s- , silicone polymers with quaternized ammonia, amino silicones, quaternium-18 silicone, amodimethicone, phenyltrimethicone, amino silicone polyethers, polyglycerol-3-disyloxane dimethicone, polyglycerol-3 polydimethylsiloxyethyl dimethicone and PEG-9 polydimethylsiloxyethyl dimethicone. Low dispersion oils may be present in the composition, but the critical aspect is the ratio of high dispersion oils to those of medium dispersion.
    [051] The ratio between high dispersion and medium dispersion oils is about 3: 1 to about 1: 3. This offers the best health benefits in a chronic application situation while also offering good skin feel without sticky residue. Skin conditioner
    [052] The composition can include at least one additional skin conditioner such as vitamins, humectant, an occlusive agent or other moisturizer to provide hydration, softness, maintain the skin barrier, not produce irritation, or other skin benefits. Some non-limiting examples of additional skin conditioners include alkyl benzoate, myristyl myristate, cetyl myristate, gelatin, carboxylic acid, lsactoc acid, glyceryl dioleate, methyl laurate, PPG-9 laurate, allantoin lauryl lactate, octyl palmitate, lanolin , propylene glycol, butylene glycol, ethylene glycol, caprylyl glycol, monobutyl ether, glycerin, fatty acids, proline, natural oils such as almond, mineral, canola, sesame, soy, pyrrolidine, wheat germ, hydrolyzed wheat protein, hydrolyzed protein oat, hydrolyzed collagen, corn, peanuts and olive oil, isopropyl myristate, myristyl alcohol, aloe vera, seaweed extract, gluconic acid, hydrolyzed silk protein, 1,3-propane-diol, vitamin E, nicatinamide, alcohol stearyl, isopropyl palmitate, sorbitol, amino acid complexes, panthenol, allantoin, dihydroxypropyltrimony chloride, hydrolyzed quaternized protein, such as collagen, oats, wheat, etc. ., inositol, fructose, sucrose, hydrolyzed plant proteins, seaweed extract, polyethylene glycol, ammonium lactate, sodium hyaluronate and cyclic peptides.
    [053] Some non-limiting examples of humectants include hydroxyethyl urea, agarose, urea, sodium PCA, arginine PCA, fructose, glucose, glutamic acid, glycerin, honey, lactose, maltose, polyethylene glycol, sorbitol and mixtures thereof.
    [054] Some non-limiting examples of occlusive agents include petrolatum, shea butter, avocado oil, lemon balm oil, cod liver oil, mineral oil, trimiristine, stearyl stearate, synthetic wax, or mixtures thereof. Some non-limiting examples of other moisturizers include ethyl hexylglyceryl, cholesterol, cystine, hyaluronic acid, keratin, lecithin, egg yolk, glycine, PPG-12, polyquaternary polymers such as polyquaternium-11, beentrimonium chloride, PEG- dihydroxypropyl chloride 5 linoleamonium, glycerol oleate, PEG-7 glycerol cocoate, cocoglycoside, hydrogenated PEG-200 glyceryl palate, panthenol, retinol, salicylic acid, vegetable oil, methyl gluceth-10, methyl gluceth-20, ethoxylated derivatives of skin conditioners such as glycereth-26 and ethoxylated shea butter and mixtures. Finally, some non-limiting examples of anti-irritants include bisabolol and panthenol.
    [055] The skin conditioner component is present in smaller amounts seen in traditional commercial skin sanitizers. The inventors found that due to the chronic use of such sanitizers, smaller amounts can be used with similar health benefits and less sticky waste. The skin conditioner or combination thereof is present in the composition in a total amount of about 0.01% by weight to about 3% by weight, preferably from about 0.05% by weight to about 2% by weight , and more preferably from about 0.1% by weight to about 1% by weight. Each individual skin conditioner is present in an amount of less than 0.5% by weight to facilitate skin health for chronic use and better touch characteristics. Vehicle
    [056] In some embodiments, the composition does not contain water. In some embodiments, there may be a vehicle, preferably water. It must be considered that the water can be deionized or softened. The water supplied as part of the concentrate can be relatively free of hardness. It is hoped that the water can be deionized to remove a portion of dissolved solids. The concentrate can be formulated with water that includes dissolved solids and can be formulated with water that can be characterized as hard water. The amount of water will vary based on the particular form of the composition, aqueous liquid, gel, emulsion, aerosol foam, or non-aerosol foam cleaner. Additional functional components
    [057] Additional functional components can be used to improve the effectiveness of the composition. Some non-limiting examples of such additional functional components include skin feel enhancers, skin conditioners, surfactants, pH-adjusting compound, preservative, antioxidants, fragrances, dyes, and the like, as well as mixtures. Terpenoid
    [058] The composition can optionally include a terpenoid. Terpenoids are defined as materials with molecular structures containing carbon structures produced from isoprene units (2 - methylbut - 1,3 - diene). Isopropene contains five carbon atoms, so the number of carbon atoms in any terpenoid is a multiple of five. Terpenoids are believed to help promote the absorption of antimicrobial compounds and preservatives by bacteria and fungi cells, thereby increasing the effectiveness of the antimicrobial or preservative compound. See US Patent No. 6,319,958 and DE 195 23 320 which are incorporated by reference in their entirety. Some non-limiting examples of terpenoids include a-terpinene, cineole, citral, citronelal, citronelol, farnesol, geraniol, limonene, linalool, metona, nerolidol, terpineol, camphene, mentone, mircene, nerol, tetrahydrogeraniol, tetrahydrolinalool, apritone and bisababol. The terpenoid is preferably farnesol, nerolidol, bisabolol or apritone.
    Bisabololapritone
    [059] The terpenoid is preferably present in the composition in an amount from about 0 to about 1% by weight, from about 0 to about 0.5% by weight and from about 0 to about 0.3 % by weight. Chelating agent
    [060] The composition can optionally include a chelating agent. Examples of chelating agents include phosphonic acid and phosphonates, phosphates, aminocarboxylates and their derivatives, pyrophosphates, ethylene diamine and ethylene triamine derivatives, hydroxy acids, and mono-, di- and tricarboxylates and their corresponding acids. Other chelating agents include nitroloacetates and their derivatives, and mixtures thereof. Examples of aminocarboxylates include amino acetates and their salts. Suitable amino acids include N-hydroxyethylaminodiacetic acid, hydroxyethylenediamine tetraacetic acid, nitrilotriacetic acid (NTA), ethylene diaminetetraacetic acid (EDTA), N-hydroxyethyl ethyl ethyl diaminetriacetic acid (HEDTA), ethylenediaminetetraacetic acid, diaminetetraacetic acid (ETA), D-ethanamine, tetraacetic acid, D-ethanamine, tetraacetic acid (D) n-hydroxyethyliminodiacetic and the like; its alkali metal salts and mixtures. Suitable aminophosphates include nitrilotrismethylene phosphates and other aminophosphates with alkyl or alkaline groups with less than 8 carbon atoms. Examples of iminodisuccinic acid polycarboxylates (IDS), sodium polyacrylates, citric acid, gluconic acid, oxalic acid, their salts, mixtures and the like. Additional polycarboxylates include citrate or citric chelating agents, polymeric polycarboxylate, and acrylic or polyacrylic acid chelating agents. Additional chelating agents include polyaspartic acid or aspartic acid co-condensates with other amino acids, C4-C25-mono or dicarboxylic acids and C4-C25-mono or diamines. Examples of polymeric polycarboxylates include polyacrylic acid, olefin / maleic copolymer, acrylic / maleic copolymer, polymethacrylic acid, copolymers of acrylic-methacrylic acid, hydrolyzed polyacrylamide, hydrolyzed polyacrylamide, hydrolyzed, polyolamide, hydrolyzed, polysaccharide; acrylonitrile-methacrylonitrile and the like.
    [061] The chelating agent can be present in an amount of about 0 to about 5% by weight, from about 0 to about 3% by weight and from about 0 to about 1.5% by weight. Preservatives
    [062] The composition can optionally include a preservative. Generally, preservatives are included in specific classes including phenolics, halogenated compounds, quaternary ammonium compounds, metal derivatives, amines, alkanolamines, nitro derivatives, biguanides, analides, organo-sulfur and nitrogen-sulfur compounds, alkyl parabens, and other compounds. Some non-limiting examples of phenolic antimicrobial agents include pentachlorophenol, orthophenylphenol, chloroxylenol, p - chloro - m - cresol, p - chlorophenol, chlorothymol, m -cresol, o - cresol, p - cresol, isopropyl cresol, cresols mixture, phenoxyethanol, phenoxyethyl paraben, phenoxyisopropanol, phenyl paraben, resorcinol, and their derivatives. Some non-limiting examples of halogen compounds include diphenyl ether trichlorohydroxide (triclosan), sodium trichloroisocyanurate, sodium dichloroisocyanurate, iodine - poly (vinylpyrolidin - onen) complexes, and bromine compounds, such as 2 - bromine - 2 - nitropropane - 1,3 - diol, and its derivatives. Some non-limiting examples of quaternary ammonium compounds include benzalkonium chloride, benzethonium chloride, beentrimonium chloride, cetrimonium chloride and their derivatives. Some non-limiting examples of amines and compounds containing nitro include hexahydro - 1,3,5 - tris (2 - hydroxyethyl) - s - triazine, dithiocarbamates, such as sodium dimethyldithiocarbamate, and their derivatives. Some non-limiting examples of biguanides include polyaminopropyl biguanide and chlorhexidine gluconate. Some non-limiting examples of alkyl parabens include methyl, ethyl, propyl and butyl paraben.
    [063] The preservative is preferably present in the composition in an amount from about 0 to about 3% by weight, from about 0.1 to about 2% by weight and from about 0.2 to about 1 % by weight. Thickener
    [064] The composition can optionally include a thickener. Examples of thickeners include (1) cellulosic and derivatives, (2) natural gums, (3) starches, (4) stearates and (5) fatty acid alcohols, (6) acrylic acid polymers and cross-linked polymers (for example, “Carbomer”, (7) Aristoflex AVC (needs a generic name) Some non-limiting examples of cellulosic thickeners include carboxymethyl hydroxyethyl cellulose, cellulose, hydroxybutyl methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, microcrystalline cellulose Some non-limiting examples of natural gums include acacia, calcium carrageenan, guar, gelatin, guar gum, hydroxypropyl guar, caraia gum, algae, locust bean gum, pectin, sodium carrageenan, tragacanth gum, xanthan gum, and the like. non-limiting examples of starches include oats, flour, potato starch, wheat flour, wheat starch and the like. Some non-limiting examples of stearates include PEG-150 distearate, PEG-22 / dodecyl glycol copolymer and the like. Some non-limiting examples of fatty acid alcohols include caprylic alcohol, cetearyl alcohol, lauryl alcohol, oleyl alcohol, palm seed alcohol and the like.
    [065] The amount of thickener in the composition depends on the desired viscosity of the composition. The composition preferably has a low enough viscosity to be pumped through a spray foamer. Surfactant
    [066] PEG-8 to PEG 12 linear dimethicone surfactants
    [067] In modalities with non-aerosol foams, the composition may include PEG-8 to PEG-12 linear dimethicone surfactants, and in particular PEG-10 dimethicone, which are more effective in producing and stabilizing foam in alcoholic compositions than dimethicone surfactants with the same PEG chain length, but with a different polymer structure.
    [068] More particularly, it has been found that linear block copolymers of PEG with polydimethylsiloxane (especially with INCI names PEG-8 dimethicone, PEG-10 dimethicone and PEG-12 dimethicone) can produce a sufficient amount of foam to be used as a component of primary foam from a non-aerosol foam alcoholic composition, which is not the case for polymers with the same INCI names, but with different polymeric structures. For example, polymers with pendent PEG groups or other highly branched polymeric structures will not produce enough foam to be used as a primary foam surfactant. In the case of PEG copolymers dimethicone, linear block copolymers refer to the polyethylene glycol chain units that are attached to the ends of the linear polydimethylsiloxane structure.
    where R = CH3 or CH2CH3, m = 4-20 on average, y = 1-5 and n = 8-12 on average.
    [069] Pending copolymers refer to linear polydimethylsiloxane polymers with PEG groups attached to the polydimethylsiloxane structure and may or may not be attached to the ends of the polydimethylsiloxane end chains. Such outstanding copolymers are described as having a comb-like structure, such as:

    [070] where R is independently = CH3, CH2CH3, or an ethoxylated alkyl chain (e.g., CH2CH2CH2O (CH2CH2O) nH), attached directly to the silicone end group and a = a repeating silicone group.
    [071] Some examples of commercially available linear PEG-8 to PEG-12 dimethicone surfactants include Silsoft 810 (PEG-8) and Silsoft 870 (PEG-12) from Momentive Performance Materials, and Silsurf DI-1010 (PEG-10) from Siltech. In some embodiments, the dimethicone surfactant is preferably PEG-10 linear dimethicone.
    [072] Dimethicone surfactant can be present in the alcoholic composition of about 0.5 to about 10% by weight, from about 1.0 to about 7% by weight and from about 2 to about 5% in weight. Other surfactants
    [073] The composition can optionally contain a surfactant or a mixture of surfactants. These can be selected from non-ionic, non-ionic, anionic, cationic, amphoteric or surface-active or zwitterionic, water-soluble or water-dispersible agents, or any combination of these. The particular surfactant or surfactant mixture chosen for use in the process and products of this invention depends on the conditions of the final utility, including production method, physical product form, pH of use and the like.
    [074] A typical list of classes and species of useful surfactants of the present invention is presented in U.S. Patent No. 3,664,961, filed May 23, 1972, to Norris. The patent description is incorporated by reference into the present invention. Additional surfactants, if present, can be in the amount of 0.5 to about 10% by weight, from about 1.0 to about 7% by weight and from about 2 to about 5% by weight. Intensifier of skin sensations
    [075] The composition can optionally include an intensifier of the sensations on the skin to improve the "feel" of the composition on the skin and hands of the user. For example, it may be undesirable for a composition to have a scaly or sandy texture when applied to the user's skin or after several applications of the composition. Non-limiting examples of these enhancers include silicone copolymers such as amodimethicone, cyclomethicone, bis-PEG / PPG-20/20 dimethicone and stearoxytrimethylsilane, esters of natural or synthetic fatty acids, and polyalkylene glycols.
    [076] If a skin sensation enhancer is included, it is preferably present in the composition in an amount of about 0.001 to about 5% by weight, from about 0.01 to about 3% by weight and about from 0.1 to about 2% by weight. Compound with pH adjustment
    [077] Sanitizing compositions of the present invention have a pH of about 4.0 to about 8. Within this pH range, the compositions effectively reduce microbial populations and are acceptable to consumers, that is, they are gentle on the skin, present stable phases and produce a stable foam. In some examples, a pH adjusting compound may be needed in an amount sufficient to produce a desired composition pH. To obtain the full advantage of the present invention, the pH adjustable compound is present in an amount of about 0.05% to about 3.5% by weight.
    [078] Examples of compounds with basic pH adjustment include, but are not limited to, ammonia, mono-, di- and trialkyl amines, mono-, di- and trialkanolamines, alkali metal and alkaline earth hydroxides; alkali metal phosphates, alkali sulfates; alkali metal carbonates and mixtures thereof. However, the identity of the basic pH adjuster is not limited and any basic pH adjuster compound known in the art can be used. Specifically, unrestricted examples of basic pH adjusting compounds are ammonia, sodium hydroxide, potassium and lithium; potassium phosphates, including hydrogen and dihydrogen phosphates; sodium and potassium carbonate and bicarbonate; sodium and potassium sulfate and bisulfate; monoethanolamine; trimethylamine; isopropanolamine; diethanolamine and triethanolamine.
    [079] The identity of the acid pH adjusting compound is not limited and any acid pH adjusting compound known in the art, alone or combined, can be used. Examples of specific acid pH adjusting compounds are mineral acids and polycarboxylic acids. Non-limiting examples of mineral acids are hydrochloric acid, nitric acid, phosphoric acid, and sulfuric acid. Non-limiting examples of polycarboxylic acids are citric acid, glycolic acid and lactic acid. Antioxidant
    [080] The composition can optionally include an antioxidant to improve the condition of the skin by removing free radicals, and improving the stability of the product. Some non-limiting examples of antioxidants include retinol and derivatives, ascorbic acid and derivatives, BHA, BHT, beta-carotene, cysteine, erythorbic acid, hydroquinone, tocopherol and derivatives, and the like.
    [081] If an antioxidant is included, it is preferably present in the composition in an amount from about 0.001 to about 2% by weight, from about 0.01 to about 1% by weight and from about 0.05 to about 0.5% by weight. Fragrance
    [082] The composition can optionally include a fragrance. Examples of possible fragrances include natural oils or naturally derived materials, and synthetic fragrances, such as hydrocarbons, alcohols, aldehydes, ketones, esters, lactones, ethers, nitriles and polyfunctional. Non-limiting examples of natural oils include the following: basil oil (Ocimum basilicum), bay oil (Pimento acris), bee balm oil (Monarda didyma), bergamot oil (Citrus aurantium bergamia), caramel oil (Elettaria cardamomum), cedarwood oil (Cedrus atlantica), chamomile oil (Anthemis nobilis), cinnamon oil (Cinnamomum cassia), citronella oil (Cymbopogon nardus), sage oil (Salvia sclarea), clove oil (Eugenia caryophyllus), clove leaf oil (Eufenia caryophyllus), Cyperus esculentus oil, cypress oil (Cupressus sempervirens), Eucalyptus citriodora oil, geranium maculatum oil, ginger oil (Zingiber officinale), grapefruit oil (Citrus grandis) , hazelnut oil (Corylus avellana), jasmine oil (Jasminum officinale), Juniperus communis oil, Juniperus oxycedrus tar, Juniperus virginiana oil, kiwi water (Actinidia chinensis), lavender oil (Lavandula hybrida), oil lavender (Lavandula angustifolia), lavender water (Lavandula angustifolia), lemon oil (Citrus medica limonum), lemon grass oil (Cymbopogon schoenanthus), lemon oil (Citrus aurantifolia), linden oil (Tilia cordata), water linden (Tilia cordata), mandarin oil (Citrus nobilis), nutmeg oil (Myristica fragrans), orange flower oil (Citrus aurantium dulcis), orange oil (Citrus aurantium dulcis), orange water (Citrus aurantium dulcis ), patchouli oil (Pogostemon cablin), peppermint oil (Menthe piperita), peppermint water (Menthe peperita), daisy oil (Rosmarinus officinalis), rose extract (Rosa damascena), rose extract (Rosa multiflora ), rosewood extract (Aniba rosaeodora), sage oil (Salvia officinalis), sandalwood oil (Santalum album), mint oil (Menthe viridis), tea tree oil (Melaleuca alternifolia), and ylang oil ylang (Cananga odorata). Some non-limiting examples of synthetic hydrocarbon fragrances include karyophyllene, fi-farnesene, limonene, α-pinene, and phyllene. Some non-limiting examples of synthetic alcohol fragrances include bacdanol, citronelol, linalool, phenethylethyl alcohol and a-terpineol (R = H). Some non-limiting examples of synthetic aldehyde fragrances include 2-methyl undecanal, citral, hexyl cinnamic aldehyde, isocicolcitral, lilial and 10-undecenal. Some non-limiting examples of synthetic ketone fragrances include cashmeran, a-ionone, isocyclemone E, koavona, muscon and tonalide. Some non-limiting examples of synthetic ester fragrances include benzyl acetate, 4-t-butylcyclohexyl acetate (cis and trans), cedryl acetate, cyclacet, isobornyl acetate and a-terpinyl acetate ((R = acetyl). Some non-limiting examples of fragrances synthetic lactone include coumarin, jasmine lactone, musk-flavored lactone, and peach-scented aldehyde.Some non-limiting examples of synthetic nitrile fragrances include cinamonitrile and gernonitrile. Finally, some non-limiting examples of synthetic polyfunctional fragrances include amyl salicylate , isoeugenol, hedione, heliotropin, lyral (or lilial) and vanilla.
    [083] The composition may include a mixture of fragrances including natural and synthetic fragrances. The fragrance can be presented in a composition in an amount of up to about 5% by weight, preferably from 0 to about 3% by weight, from about 0 to about 1% by weight and from about 0 to about 0.2% by weight. Dye
    [084] The composition can optionally include a dye. Examples of dyes include any soluble in water or the product, any approved FD&C or D&C dye. Form of the compositions
    [085] The compositions of the invention can be supplied as an aqueous liquid, structured liquid or emulsion. The composition is preferably supplied ready for use, meaning that the composition does not need to be diluted initially. Production methods of compositions
    [086] The compositions of the invention are easily produced by a large number of techniques known in the art. Conveniently, a portion of the water is supplied to a suitable mixing vessel with a stirrer, and during stirring, the remaining constituents are added to the vessel, including any final amount of water necessary to produce 100% by weight of the composition of the invention.
    [087] The compositions can be packaged in any suitable container, particularly vials or bottles, including metering vials, as well as vials provided with a spray device (eg spray actuated), which is used to supply the composition by spraying. The selected package may have a foam dispenser with a dispenser. Examples of dispensers include F2 from Rexam PLC (London, England, called airspray), and RF-17 Palm from Riecke Corporation (Auburn, Indiana). In this way, the compositions are desirably supplied as a ready-to-use product in a manually operated dispenser.
    [088] The composition can be supplied in various packaging sizes. Examples of sizes include 1.5 oz (42.62 mL), 500 mL and 1 liter bottles.
    [089] Although the compositions of the present invention are used in the types of liquid forms described, there is nothing described in this specification that limits the use of the composition with an amount of water to form a solution. Likewise, there is nothing in the specification that prevents the formation of a “super-concentrated” composition based on the composition described above. Such a super-concentrated composition is essentially the same composition described above except that it includes a smaller amount of water. Methods using sanitizing compositions
    [090] The invention includes a method for reducing the population of a microorganism on the skin, a method of treating a skin disease and the like. These methods bring the composition of the invention into contact with the body. The contact may include any of the methods of applying the composition of the invention, such as spraying, dipping, foam or gel treating the skin with the composition or a combination thereof.
    [091] The combinations of the invention can be included in any product applied to the skin such as sanitizers, deodorants, antiseptics, fungicides, germicides, virucides, hand sanitizers without water, and pre or post-surgical brushes, pre-skin products operative.
    [092] The present invention will be illustrated by the following non-limiting examples. Examples
    [093] The summary, detailed description and examples offer a basis for understanding the invention, and some specific embodiments of the invention. Since the invention can comprise a variety of embodiments, the above information is not limiting. The invention is based on the claims. With formula portions (used in panels and clinical tests)

    Market leading nutritive foam Active component 70% v / v ethyl alcohol Inactive components Water (aqua), isopropyl alcohol, glycerin, PEG-12 dimethicone, caprylyl glycol, hydroxyethyl urea, isopropyl myristate, tocopheryl acetate Low dispersion oil: PEG-12 dimethicone Medium dispersion oil: isopropyl myristate High dispersion oil: none Example 1 Sensation of the product and putting on gloves Healthcare professionals were recruited to participate in the study, with a total of 45 participants. TEST PRODUCT MLNF = market-leading nutritive foam Test procedure 1. Participants washed their hands with a mild hand soap and then dried their hands carefully with a paper towel. 2. The participants then removed an application of the product from a non-touch dispenser (~ 0.7 mL) and rubbed their hands until dry. 3. The participants then recorded their observations about the sensation of the product during and after application. 4. Two additional product applications were performed making sure that the participants' hands were dried between applications. 5. After the third application, the participants applied a nitrile glove to their hands that they do not use to write. 6. After fitting the glove, participants recorded the ease of fitting the glove on a 7-point scale and rated the product for full acceptance on a 9-point scale. 7. After a complete evaluation of the first product, participants washed and dried their hands with mild liquid soap. 8. Steps 2 through 6 were repeated for the second product. 9. The order of the product was random for the group of participants.
    [094] The results for full acceptance were subjected to statistical analysis with a general linear model. The group's information used the Tukey method and 95.0% confidence. Table 1 presents a summary:

    [095] The averages that do not share a letter are significantly different.
    [096] The results are shown graphically in figure 1. There was a statistically significant increase in total acceptance with the product of the invention.
    [097] The next results for glove placement were submitted to a general linear model: Glove placement X participant, product number, order. The group's information uses the Turkey method and 95.0% confidence. A summary of the results is shown in table 2.

    [098] The averages that do not share a letter are significantly different.
    [099] The results are presented graphically in figure 2. From the results, it was observed that there was a statistically significant increase in the total acceptance of the product of the invention in relation to the commercially available product. Example 2 Test of controlled application on the forearm Initial test subjects: 45 Products: Nutritional test formula 1 (NTF 1) Nutritional test formula 2 (NTF 2) MLNF = market leading nutritive foam Treatments: Untreated skin Nutritional test formula 1 (NTF 1) Nutritional test formula 2 (NTF 2) MLNF = market leading nutritive foam Test methods: Corneometer (skin hydration) Visual dryness (assessed by a specialist using a 5 point scale and magnification) Tewameter ( loss of water from the skin) Procedure:
    [0100] Forearm locations were selected for each individual, and 1.25 ”(3.18 cm) circles were marked. The application of the product on site was random at the beginning of the study. The basic readings were taken before applying the product. 1. The product was applied in the appropriate position on the forearm twice a day. A minimum of three hours was maintained between treatments with one side left untreated. 2. The two applications per day were performed for 4 continuous days. 3. On the 5th day, a single application was performed. 4. After a minimum of three hours after the single application on the 50th day, the final readings were taken.
    [0101] The use of test product # 1 with 62% ethanol (w / w) was not statistically different from the untreated control in terms of erythema, dryness or skin moisture content, but it was statistically different from the control in terms of loss transepidermal water.
    [0102] The results were submitted to the General Linear Model of statistical analysis: visual dryness X test material, individual. The group's information used the Turkey method and 95.0% confidence. A summary of the results is shown in table 3.

    [0103] The averages that do not share a letter are significantly different. None of the compositions showed a statistically different change in visual dryness. The results are described graphically in figure 3.
    [0104] The results for redness were subjected to statistical analysis. General linear model: visual redness vs. test material, individual.
    [0105] The group's information used the Turkey method and 95.0% confidence. A summary of the results is shown in table 4.


    [0106] The averages that do not share a letter are significantly different.
    [0107] The results are described graphically in figure 4. Again, all products were statistically similar despite the fact that the compositions of the invention have less skin conditioning components.
    [0108] Next, the results of the corneometer test were subjected to statistical analysis. General linear model: corneometer X treatment of the individual 1. The group information used the Tukey method and 95.0% confidence. The results are shown in table 5.

    [0109] The averages that do not share a letter are significantly different. It can be seen that the composition of the invention showed similar hydration readings compared to untreated skin, while the commercially available product showed a statistically significant change in skin hydration as measured by the corneometer. The results are shown graphically in figure 5.
    [0110] Then the transepidermal water loss was measured and the results were subjected to statistical evaluation. One-way ANOVA: TEWL X treatment.
    [0111] The group's information used the Tukey method and 95.0% confidence. The results are shown in table 6.
    The averages that do not share a letter are significantly different. Tukey method with 95% simultaneous confidence intervals. All comparisons were matched between treatment levels. Individual confidence level = 98.98%.
    [0112] The results are shown graphically in figure 6. Both compositions of the invention were statistically and significantly different from the commercial nutritional formula. Example 3 Test of controlled application on the leg Initial test subjects: 38 Products: Test product A (test product, SNF) Market leading foam sanitizer, MLFS Antibacterial foam hand soap (AB soap) Treatments: Untreated skin AB soap and water three times a day MLFS 30 times a day with 3 uses of AB soap and washes with SNF water 30 times a day with 3 uses of AB soap and water washes Test methods: Corneometer (skin hydration) Visual dryness (assessed by a specialist using a magnification and a 5-point scale) Procedure:
    [0113] The subjects were selected for the study because they had moderately dry skin determined by a specialist. Two locations on the back of each leg were marked. The application of the product on site was random at the beginning of the study. The basic readings were taken before applying the product. 1. Wash three places with AB soap and water, leave one spot untreated. 2.Apply 10 product applications (either MLFS or SNF in the respective locations). 3. Wash the three places again with AB soap and water. 4. Perform 10 more product applications. 5. Wash the three places again with AB soap and water. 6. Perform 10 more product applications.
    [0114] Measurements and observations were made after five days of the test; the individuals spent two days without applying the product. The process was repeated for a total of three consecutive weeks (15 days of product application). Visual dryness
    [0115] Figure 7 is a graph of the results of the controlled application test on the legs showing visual dryness. It can be seen that the product of the invention, even with 30 washes per day, was more similar to untreated skin while both commercial sanitizers showed a great change in dryness.
    [0116] No statistical difference was observed between untreated skin and SNF during the three weeks of the study. The untreated skin and the one treated with SNF showed significantly less changes in relation to visual dryness than those treated with soap AB and MLSF during the three weeks of the study.
    [0117] Corneometer (skin hydration by capacitance)
    [0118] Figure 8 is a graph of the results of the controlled application test on the legs showing dryness measured with a corneometer (skin hydration by capacitance). Again, the results demonstrated that the composition of the invention had a higher hydration content than the skin treated with any of the commercial compositions. Example 4 Participants: 27
    [0119] TGS-A and TGS-B were test products and test product B is a hand sanitizer. Competitive alcohol gel B and market-leading competitive gel A were competitive products. Participants tested two products per visit. The products were compared in a paired comparison test with random order. All combinations were tested in a complete block design. Mini-tab was used to calculate statistical significance. Procedure: 1. Wash your hands with a regular soap provided, then dry your hands thoroughly with paper towels. 2. Apply a dose of the product from the bottle indicated on the hands and observe the quality of the gel. 3. Rub the product in your hands until they dry. 4.Repeat the application of the product up to five times (be sure to mark the appropriate line for question 5 after drying each application of the product, and inform the assistant if at any time you felt the need to wash your hands (after the drying of any application, question 6) .5 .After drying the fifth application, put on a glove and answer question 18 on the ease of fitting the glove. 6 .Answer the remaining questions (up to questions 19-21) of product evaluation questionnaire 7 .Repeat the procedure to evaluate the next product.
    [0120] Issues related to glove placement: Please assess resistance (if any) during glove placement after the 5th application. Check the box that best applies:


    [0121] The results that share a letter are not significantly and statistically different. The results that do not share the letter are statistically and significantly different. Example 5 Participants: 36
    [0122] TEST C PRODUCT was the test product and TEST B PRODUCT is a hand sanitizer. Purell Advanced Instant Hand Sanitizer was the market's leading competitive product. Participants tested two products per test. Two tests were performed in one day. The products were compared in a paired comparison test with random order. Mini-tab was used to calculate statistical significance. Comparisons made: PRODUCT TEST C X PRODUCT TEST B PRODUCT TEST C X gel A competitive market leader
    [0123] Procedure: 1. Wash your hands with the usual soap provided, then dry your hands thoroughly with paper towels. 2. Apply a dose of the product from the bottle indicated on the hands and observe the quality of the gel. 3. Rub the product in your hands until they dry. 4.Repeat the application of the product for a total of three applications. Answer the appropriate questions. 5. After drying the third application, put on a glove and answer the question about the ease of fitting the glove. 6. Answer the remaining questions of the product evaluation questionnaire. 7.Repeat the procedure to evaluate the next product.
    [0124] Question asked in the essay
    [0125] (with difficulty = 1, extremely easy = 7):
    [0126] Please rate the glove placement:

    [0127] The averages that do not share a letter are significantly different.

    Line product Low dispersion oil: limnanto seed oil, polyethylene glycol 1450, cetyl alcohol, and polydimethyl siloxane emulsion (2.45% w / w) Medium dispersion oil: isopropyl palmitate (total 0.25% w / p) High dispersion oil: cyclomethicone (total 0.5% w / w) Gel A competitive market leader Active component Purpose Ethyl alcohol 70% antimicrobial
    [0128] Inactive components: water (aqua), isopropyl alcohol, caprylyl glycol, glycerin, isopropyl myristate, tocopheryl acetate, crossed polymers of acrylates / C10-30 alkyl acrylate, aminomethyl propanol, fragrance (perfume) Low dispersion oil: none Oil medium dispersion: isopropyl myristate High dispersion oil: no competitive B-gel 85% ethyl alcohol Inactive components: cross polymer of acrylates / C10-30 alkyl acrylate, bisabolol, cyclomethicone, glycerin, isoexadecane, myristyl alcohol, PVP, tetrahydroxypropyl ethylenediamine, water Low dispersion oil: myristyl alcohol Medium dispersion oil: none High dispersion oil: cyclomethicone, isoexadecane Example 6 Participants: 30
    [0129] NTF-2, NTF-1, market-leading nutritional foam (MLNF) were compared in a complete block design. The products were tested as pairs with one pair tested per day. Procedure: 1. Wash your hands with a mild soap provided. 2. Apply a dose of the dispenser product in your hands and observe the quality of the foam. 3. Rub the product in your hands until they dry. 4.Repeat the application of the product for a total of five applications (be sure to check the appropriate row for questions one and two after each drying of the application). 5. After drying the fifth application, put on a pair of gloves provided and record the difficulty in putting on the gloves. 6. Answer the remaining questions of the product evaluation questionnaire. 7. Wash your hands with soap and dry well. 8. Repeat steps 4 through 11.
    [0130] Question about putting on gloves:
    [0131] Please rate the skill in putting on the gloves after 5 applications of the product (choose one).
    Without resistance = 1, with difficulty = 4 General linear model: placement of gloves X individual, product name, ...
    [0132] Group information using the Tukey method and 95.0% confidence

    [0133] The averages that do not share a letter are significantly different.
    权利要求:
    Claims (15)
    [0001]
    1. Liquid skin sanitizing composition, CHARACTERIZED by the fact that it comprises: a) one or more skin conditioners; b) a medium dispersion emollient; c) a high dispersion emollient; d) a straight or branched C1 to C6 alcohol; and e) water in which the said ratio of high dispersion emollient to medium dispersion emollient is 3 to 1 to 1 to 3 by weight, wherein said alcohol C1 to C6 is in an amount of 50% by weight to 90% by weight of said composition, wherein said one or more skin conditioners total no more than 3% by weight of said composition, wherein said medium dispersion emollient includes one or more of: capric / caprylic triglyceride, C12- alkyl 15 benzoate, capric triglyceride, caprylic triglyceride, isopropyl myristate, isopropyl palmitate, octyldodecanol, decyl oleate, cocoglycerides, ethylhexyl stearate, cetearyl isononanoate, cetearyl ethylhexanonate, decyl cocoate, polyethyl ether, ethyl acetate stearyl, dimethicone fluid (1x10-5 m2 / s to 2x10-5 m2 / s (10 to 20 cSt)), and PPG-14 butyl ether, in which the said high dispersion emollient includes one or more tipprilyl carbonate, dibutyl adipate, hexil lau rat, tipprilic ether, propylheptyl caprylate, silicone oil with 4x10-6 m2 / s 1x10-6 m2 / s (4-10 centistoke), cyclic siloxane D4, 5 or 6, isocetyl palmitate, hydrogenated polyisobutene, and diethylhexyl carbonate, in that said skin conditioner is one or more of the following: alkyl benzoate, myristyl myristate, cetyl myristate, gelatin, carboxylic acid, lactic acid, glyceryl dioleate, methyl laurate, PPG-9 laurate, lauryl lactylate, allantoin, octyl palmitate, lanolin, propylene glycol, butylene glycol, ethylene glycol, caprylyl glycol, monobutyl ether, glycerin, fatty acids, proline, natural oils such as almond oil, mineral, canola, sesame, soy, pyrrolidine, wheat germ, hydrolyzed protein wheat, hydrolyzed oat protein, hydrolyzed collagen, corn, peanuts and olive, isopropyl myristate, myristyl alcohol, aloe vera, seaweed extract, gluconic acid, hydrolyzed silk protein, 1,3-propane-diol, vitamin E, nicatinamide, alcohol stearyl ool, isopropyl palmitate, sorbitol, amino acid complexes, panthenol, dihydroxypropyltrimony chloride, hydrolysed quaternized protein, such as collagen, oats, wheat, inositol, fructose, sucrose, hydrolyzed plant proteins, seaweed extract, polyethylene glycol, lactate ammonium, sodium hyaluronate, betaine, cyclic peptides, hydroxyethyl urea, agarose, urea, sodium PCA, arginine PCA, fructose, glucose, glutamic acid, glycerin, honey, lactose, maltose, polyethylene glycol, sorbitol, petrolate, shea butter , avocado oil, lemon balm oil, cod liver oil, mineral oil, trimiristin, stearyl stearate, synthetic wax, ethyl hexylglyceryl, cholesterol, cystine, hyaluronic acid, keratin, lecithin, egg yolk, glycine, PPG- 12, polyquaternary polymers, such as polyquaternium-11, beentrimonium chloride, dihydroxypropyl chloride PEG-5 linoleamonium, glycerol oleate, PEG-7 glycerol cocoate, cocoglycoside, hydrogenated PEG-200 glyceryl palate, panthenol, retinol, salicylic acid, vegetable oil, methyl gluceth-10, methyl gluceth-20, ethoxylated derivatives of glycereth-26, ethoxylated shea butter, bisabolol, panthenol and mixtures thereof.
    [0002]
    2. Liquid skin sanitizing composition, according to claim 1, CHARACTERIZED by the fact that said one or more skin conditioners total no more than 2% by weight of said composition.
    [0003]
    3. Liquid skin sanitizing composition, according to claim 1 or 2, CHARACTERIZED by the fact that said one or more skin conditioners total no more than 1% by weight of said composition.
    [0004]
    4. Liquid skin sanitizing composition, according to claim 1, CHARACTERIZED by the fact that each conditioner is present in an amount of no more than 1% by weight of said composition.
    [0005]
    5. Liquid skin sanitizing composition, according to claim 1, CHARACTERIZED by the fact that each conditioner is present in an amount of no more than 0.8% by weight of said composition.
    [0006]
    6. Liquid skin sanitizing composition, according to claim 1, CHARACTERIZED by the fact that each conditioner is present in an amount of no more than 0.5% by weight of said composition.
    [0007]
    7. Liquid skin sanitizing composition according to any one of claims 1 to 6, CHARACTERIZED by the fact that the said ratio of high dispersion emollient to medium dispersion emollient is 1: 3.
    [0008]
    Liquid skin sanitizing composition according to any one of claims 1 to 7, CHARACTERIZED by the fact that said composition is in the form of a fine aqueous liquid, a gel, an emulsion, or an aerosol foam.
    [0009]
    9. Skin sanitizing method, CHARACTERIZED by the fact that it comprises applying the liquid skin sanitizer, as defined in any one of claims 1 to 8, to a skin surface; and, subsequently, let said sanitizer dry.
    [0010]
    10. Method, according to claim 9, CHARACTERIZED by the fact that the said application and drying steps are repeated from 20 to 100 times a day.
    [0011]
    11. Method, according to claim 9 or 10, CHARACTERIZED by the fact that said skin is not sticky or sandy with drying.
    [0012]
    12. Method according to any one of claims 9 to 11, CHARACTERIZED by the fact that said dry skin facilitates the placement of gloves.
    [0013]
    13. Method according to any of claims 9 to 12, CHARACTERIZED by the fact that said sanitized skin has improved health and hydration compared to untreated skin that is sanitized 20 to 100 times a day.
    [0014]
    14. Liquid skin sanitizing composition, according to claim 1, CHARACTERIZED by the fact that it comprises: a) one or more skin conditioners; b) a medium dispersion emollient; c) a high dispersion emollient; d) a straight or branched C1 to C6 alcohol; e) water in which said one or more skin conditioners are present in an amount of no more than 0.5% by weight each and yet in which said component of the total skin conditioner comprises no more than 1% by weight of said sanitizing composition.
    [0015]
    15. Liquid skin sanitizing composition according to claim 14, CHARACTERIZED by the fact that said composition is in the form of a fine aqueous liquid, a gel, an emulsion, a non-aerosol foam, or an aerosol foam.
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    同族专利:
    公开号 | 公开日
    US20180228707A1|2018-08-16|
    CA2909787A1|2014-12-11|
    US10786436B2|2020-09-29|
    US20160346178A1|2016-12-01|
    AU2019200343B2|2019-07-11|
    US10588836B2|2020-03-17|
    AU2019200343A1|2019-02-07|
    AU2014275388A1|2015-10-29|
    US20190290561A1|2019-09-26|
    WO2014197168A1|2014-12-11|
    AU2014275388B2|2018-11-01|
    US9962323B2|2018-05-08|
    US20140364509A1|2014-12-11|
    US20210015727A1|2021-01-21|
    BR112015030649A2|2017-07-25|
    US9439841B2|2016-09-13|
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    法律状态:
    2018-02-27| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2019-07-30| B06U| Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure|
    2020-04-14| B06A| Notification to applicant to reply to the report for non-patentability or inadequacy of the application according art. 36 industrial patent law|
    2020-07-28| B09A| Decision: intention to grant|
    2020-12-01| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/05/2014, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
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    US13/911.524|2013-06-06|
    US13/911,524|US9439841B2|2013-06-06|2013-06-06|Alcohol based sanitizer with improved dermal compatibility and feel|
    PCT/US2014/037601|WO2014197168A1|2013-06-06|2014-05-10|Alcohol based sanitizer with improved dermal compatibility and feel|
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