wireless sensor plasters and manufacturing methods

专利摘要:
abstract wireless sensor patches include a skin-friendly adhesive and a flexible cover patch. in further examples, methods of manufacturing a plurality of wireless sensor patches include the step (i) of unwinding a flexible support membrane from a support membrane storage roll along an assembly path. the flexible support membrane is provided with a skin adhesive configured to mount a first face of the flexible support membrane to a skin surface. the method further comprises the step (ii) of sequentially mounting a plurality of sensor devices with respect to a second face of the flexible support membrane along a longitudinal axis of the assembly path. the method further includes the step (iii) of sequentially separating the flexible support membrane to provide the plurality of wireless sensor patches, wherein each wireless sensor patch includes a corresponding one of the plurality of sensor devices. Abstract of the Patent Summary of the Invention: "Wireless Sensor Plasters and Manufacturing Methods" The present invention relates to wireless sensor plasters which include a non-aggressive skin adhesive and a flexible cover plaster. In further examples, methods of manufacturing a plurality of wireless sensor plasters include the step for (i) unwinding a flexible support membrane from a support membrane storage roller along an assembly path. The flexible support membrane is provided with a skin adhesive configured to mount a first face of the flexible support membrane to a skin surface. The method further comprises the step for (ii) sequentially mounting a plurality of sensor devices relative to a second face of the flexible support membrane along a longitudinal geometric axis of the mounting path. The method further includes the step for (iii) sequentially separating the flexible support membrane to provide the plurality of wireless sensor patches, wherein each wireless sensor patch includes a corresponding device from the plurality of sensor devices.
公开号:BR112015017477A2
申请号:R112015017477
申请日:2014-01-23
公开日:2020-02-04
发明作者:Silvestro David；A Armijo Edward；Adams James；R Onderisin Michael；Hruska Ryan
申请人:Avery Dennison Corp；
IPC主号:

专利说明:

Descriptive Report of the Invention Patent for WIRELESS SENSOR PLASTERS AND MANUFACTURING METHODS.
Cross Reference to Related Applications [0001] This application claims the benefit of Provisional Patent Application No. ² US 61 / 755,523, filed on January 23, 2013 and Provisional Patent Application No. ² US 61 / 755,629, filed on January 23, 2013, which are incorporated into this document as a reference in their entirety.
Field of the Invention [0002] The present invention relates to wireless sensor patches and manufacturing methods and, more particularly, to wireless sensor patches that include a flexible support patch and a flexible cover patch and methods for manufacture a plurality of wireless sensor patches.
Background of the Invention [0003] Sensors for monitoring various parameters of a patient are known. These sensors can include temperature sensors, Electrocardiogram (ECG) sensors, Galvanic Skin Response (GSR) sensors depending on the application of the sensor. In some applications, the sensors can be attached by wire to a device configured to process and / or display information obtained by the sensors. In the additional examples, the sensors are recognized for comprising wireless sensors that communicate with another wireless device. There is a desire to provide wireless sensor patches to monitor a patient's various parameters. There is also a desire to provide manufacturing methods to sequentially manufacture a plurality of wireless sensor patches in an efficient and cost-effective manner.
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Brief Summary of the Invention [0004] The embodiments of the present invention described below are not intended to be exhaustive or to limit the invention to the precise forms disclosed in the detailed description above. Preferably, the modalities are chosen and described, so that others skilled in the art can appreciate and understand the principles and practices of the present invention.
[0005] In a first aspect of the disclosure, a method for manufacturing a plurality of wireless sensor patches comprises the step (I) of unwinding a flexible support membrane from a support membrane storage roller along a assembly trajectory. The flexible support membrane is provided with a skin adhesive configured to mount a first face of the flexible support membrane on a skin surface. The method further comprises the step (II) of sequentially assembling a plurality of sensor devices with respect to a second face of the flexible support membrane along a longitudinal geometric axis of the assembly path. The method further includes step (III) of sequentially separating the flexible support membrane to provide the plurality of wireless sensor patches, wherein each wireless sensor patch includes a corresponding device among the plurality of sensor devices.
[0006] In an example of the first aspect, after step (II) and before step (III), the method additionally includes the steps of: providing a plurality of flexible covering patches and fixing each flexible covering patch in relation to second face of the flexible support membrane, so that each of the plurality of sensor devices is at least partially housed within a pocket defined by at least one of the
3/50 flexible support and the corresponding flexible cover plaster. For example, the step of fixing each flexible cover plaster may include the steps of applying a bonding layer to the second face of the flexible support membrane and then laminating the flexible cover plaster to the second face of the flexible support membrane with the bonding layer.
[0007] In another example of the first aspect, the method additionally includes the steps of: unwinding a flexible cover membrane from a flexible cover membrane storage roller and sequentially separating the plurality of flexible cover plasters from the membrane flexible coverage. For example, the method may additionally include the step of forming a plurality of pockets in the flexible cover membrane along a longitudinal geometric axis of the flexible cover membrane and wherein the step of sequentially separating the plurality of flexible cover plasters provides each flexible cover plaster with a corresponding pocket between the pockets to house at least partially a corresponding device among the sensor devices.
[0008] In yet another example of the first aspect, step (III) provides the flexible support membrane as a plurality of flexible support patches that are each provided with a corresponding flexible cover patch attached to a second face of the flexible support plaster. In one example, an occupation area of each flexible support plaster is greater than an occupation area of the corresponding fixed flexible plaster covering.
[0009] In yet another example of the first aspect, the skin patch is provided as a non-aggressive skin patch, for example, a hydrocolloid skin patch. In another example, the
4/50 skin additionally includes an adhesive layer applied to the first face of the flexible support membrane. In these examples, methods can be provided where step (I) assembles the non-aggressive adhesive to the skin in relation to the first face of the flexible support membrane with the adhesive layer. In a further example, step (III) provides the flexible support membrane as a plurality of flexible support plasters which are each provided with a plaster of the adhesive layer applied to a first face of the flexible support plaster. In yet another example, step (I) assembles the skin-friendly adhesive as a plurality of skin-friendly adhesive plasters, in which at least one of the skin-friendly adhesive plasters is mounted on the first face of the support plaster flexible with adhesive layer plaster. In another example, step (I) assembles at least one of the non-aggressive adhesive plasters to the skin on the first face of each corresponding flexible support plaster, so that an outer periphery of the plaster of the adhesive layer circumscribes at least one among non-aggressive adhesive plasters to the skin.
[0010] In yet another example of the first aspect, the method further comprises the step of providing evidence for a portion of each wireless sensor patch containing information that corresponds to evidence information provided in a corresponding packaging that houses each sensor patch without thread.
[0011] In another example of the first aspect, the method further comprises the step of associating evidence from a portion of the wireless sensor patch with a batch of at least one source of mounting materials used to manufacture the wireless sensor patch.
5/50 [0012] In a further example of the first aspect, a wireless sensor patch is manufactured according to the first aspect discussed above or any of the examples of the first aspect discussed above, wherein the wireless sensor patch comprises a flexible support plaster that includes a first face and a second face with an external periphery defining an area of occupation of the flexible support plaster. The wireless sensor patch additionally includes an adhesive layer applied to the first face of the flexible support patch and a skin-friendly adhesive patch mounted on the first face of the flexible support patch with the adhesive layer. The wireless sensor patch additionally includes a sensor device mounted on the second face of the flexible support patch, wherein the sensor device includes at least one sensor probe aligned with an opening extending through the flexible support patch. The wireless sensor patch additionally includes a flexible cover patch mounted on the second face of the flexible support patch, in which the sensor device is housed at least partially within a pocket defined by at least one of the flexible support patch and the corresponding flexible cover plaster. In another example, the wireless sensor patch additionally includes a bonding layer that mounts the flexible cover patch to the second face of the flexible support patch. In another example, the wireless sensor patch provides the flexible support patch like a fabric, like a non-woven fabric. In the additional examples, a flexible support patch occupation area is greater than a flexible cover patch occupation area. Still in the additional examples, an outer periphery of the adhesive layer circumscribes the non-aggressive adhesive patch to the skin. In the additional examples, the adhesive plaster
6/50 non-aggressive to the skin comprises a hydrocolloid adhesive patch. [0013] The first aspect discussed above can be provided alone or in combination with any one or more of the examples of the first aspect discussed above.
[0014] In a second aspect of the disclosure, a method for fabricating a plurality of wireless sensor patches comprises the step (I) of unrolling a non-aggressive skin adhesive membrane from a non-aggressive adhesive membrane storage roller skin. The non-aggressive skin adhesive membrane includes a substrate sheet that carries a layer of non-aggressive skin adhesive and a first release liner carried by the non-aggressive skin adhesive layer. The non-aggressive skin adhesive layer is sandwiched between the first release liner and the substrate sheet. The method additionally comprises step (II) for cutting the substrate sheet and the non-aggressive skin adhesive in the first release liner to define a non-aggressive skin adhesive patch. The method also includes step (III) of unrolling a flexible support membrane from a support membrane storage roller, wherein the flexible support membrane includes a flexible support blade with a layer of skin adhesive applied to a first face of the flexible support blade and a second release liner carried by the skin adhesive layer, wherein the skin adhesive layer is sandwiched between the second release liner and the flexible support blade. The method additionally includes step (IV) to cut the flexible support blade to the side and the skin adhesive layer on the second release liner to define an opening extending through the flexible support blade and the skin adhesive layer . The method also includes step (V) of removing the second release liner in order to expose the skin adhesive layer. The method
7/50 also includes step (VI) for laminating the substrate sheet to the flexible support blade with the skin adhesive layer of the flexible support membrane. The method also includes step (VII) of unwinding a bonding membrane from a bonding membrane storage roller, wherein the bonding membrane includes a bonding layer that carries a third liner. release. The method additionally includes step (VIII) of flushing the bonding layer in the third release liner to define a bonding layer plaster and step (IX) for laminating the bonding layer plaster to the flexible support blade. The method also includes step (X) of cutting at least one probe opening through the bonding layer membrane in alignment with the opening defined during step (IV) and step (XI) to remove the third release liner a in order to expose the laminated bonding layer plaster to the flexible support blade. The method further includes the step (XII) of mounting a sensor device in relation to the flexible support membrane with a sensor probe in alignment with corresponding openings defined during steps (IV) and (X). The method also includes the step (XIII) of unrolling a flexible roofing membrane from a flexible roofing membrane storage roller and the step (XIV) of forming a pocket within the flexible roofing membrane. The method further includes the step (XV) of cutting the flexible roofing membrane to define a flexible roofing plaster that includes the pocket and the step (XVI) of laminating the flexible roofing plaster on the bonding layer plaster, where the sensor device is at least partially received in the pocket. The method also includes the step (XVII) of cutting the flexible support blade and the skin adhesive layer to provide a wireless sensor patch.
8/50 [0015] In an example of the second aspect, step (XVII) provides an external periphery of the skin adhesive layer that circumscribes the non-aggressive adhesive plaster to the skin.
[0016] In another example of the second aspect, the non-aggressive skin patch comprises a hydrocolloid skin patch.
[0017] In another example of the second aspect, the flexible support membrane comprises a fabric, such as a non-woven fabric.
[0018] In another example of the second aspect, step (XVII) is performed periodically to produce sequentially a plurality of wireless sensor patches.
[0019] In yet another example of the second aspect, the method includes the step of providing evidence for a portion, where each wireless sensor patch contains information that corresponds to indication information provided in a corresponding package that houses each sensor patch. wireless.
[0020] In yet another example of the second aspect, the method further comprises the step of associating evidence from a portion of the wireless sensor patch to a batch of at least one source of mounting materials used to manufacture the wireless sensor patch. .
[0021] The second aspect can be provided alone or in combination with any one or more of the examples of the second aspect discussed above.
[0022] According to a third aspect, a wireless sensor patch comprises a flexible support patch that includes a first face and a second face with an external periphery defining an occupation area of the flexible support patch. The wireless sensor patch additionally includes an adhesive layer applied to the first face of the flexible support patch.
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The wireless sensor patch also includes a non-aggressive skin adhesive patch mounted on the first face of the flexible support patch with the adhesive layer and a sensor device mounted on the second face of the flexible support patch. The sensor device includes at least one sensor probe aligned with an opening that extends through the flexible support patch. The wireless sensor patch additionally includes a flexible cover patch mounted on the second face of the flexible support patch, wherein the sensor device is at least partially housed within a pocket defined by at least one of the flexible support patch and the corresponding flexible cover plaster.
[0023] In an example of the third aspect, the wireless sensor patch includes a bonding layer that mounts the flexible cover patch on the second face of the flexible support patch. [0024] In another example of the third aspect, the flexible support plaster comprises a fabric, such as a non-woven fabric. [0025] In yet another example of the third aspect, an area of occupation of the flexible support plaster is greater than an area of occupation of the flexible cover plaster.
[0026] In yet another example of the third aspect, an external periphery of the adhesive layer circumscribes the non-aggressive adhesive plaster to the skin.
[0027] In yet another example of the third aspect, the non-aggressive skin adhesive patch comprises a hydrocolloid adhesive patch.
[0028] The third aspect discussed above can be provided alone or in combination with any one or more of the examples of the third aspect discussed above.
[0029] According to a fourth aspect, a sensor patch
Wireless 10/50 comprises a flexible printed circuit board and at least one electronic component mounted on the flexible printed circuit board and extending on a first side of the flexible printed circuit board. The wireless sensor patch includes a non-aggressive adhesive skin patch mounted on a second side of the flexible printed circuit board and a flexible cover patch mounted in relation to the non-aggressive skin adhesive patch with the electronics positioned within a space between the flexible covering patch and the non-aggressive adhesive patch on the skin. The wireless sensor patch additionally includes a damping layer positioned to extend between the electronics and the flexible cover patch.
[0030] In an example of the fourth aspect, the wireless sensor patch additionally includes a bonding layer that mounts the skin-friendly adhesive patch on the second side of the flexible printed circuit board.
[0031] In yet another example of the fourth aspect, the wireless sensor patch additionally includes at least one electrode extending from a second side of the flexible printed circuit board and extending through a through opening defined by the patch non-aggressive adhesive to the skin. In one example, an electrode insulating member is positioned within the through opening defined by the non-aggressive skin adhesive patch and circumscribes the electrode to avoid contact between the electrode and the skin non-aggressive adhesive patch. In an additional example, the electrode extends through an opening defined by the electrode insulation member.
[0032] In yet another example of the fourth aspect, the wireless sensor patch additionally includes at least a first electrode and a second electrode, each of which extends from a
11/50 second side of the flexible printed circuit board and each extends through at least one through opening defined by the non-aggressive adhesive plaster to the skin. For example, the wireless sensor patch may include at least one electrode insulating member positioned within at least one through opening of the non-aggressive skin patch to prevent contact between at least one of the electrodes and the non-aggressive adhesive patch. the skin. In one example, the electrode insulating member prevents both the first electrode and the second electrode from coming into contact with the skin-friendly adhesive patch. In another example, the electrode insulating member includes a first opening that receives the first electrode and a second opening that receives the second electrode.
[0033] In another example of the fourth aspect, if the electrode insulation member is provided, the electrode insulation member can optionally be received within a single through opening defined by the non-aggressive adhesive plaster to the skin.
[0034] In yet another example of the fourth aspect, if the electrode insulation member is provided, the electrode insulation member may optionally be shaped like an 8.
[0035] In another example of the fourth aspect, the flexible covering patch defines a viewing port configured to allow viewing of a portion of the damping layer through the flexible covering patch viewing port. For example, the damping layer may include clues that can be seen through the flexible cover plaster viewing port.
[0036] In another example of the fourth aspect, the cushion layer comprises a fabric. In some instances, the fabric comprises a non-woven fabric.
12/50 [0037] In yet another example of the fourth aspect, the flexible covering plaster has an occupation area that is larger than an occupation area of the non-aggressive adhesive plaster to the skin. For example, an adhesive occupation area of the wireless sensor patch may include a portion of non-aggressive skin adhesive defined by the non-aggressive skin adhesive patch that is circumscribed by a peripheral adhesive portion defined by an adhesive layer of the covering patch. flexible.
[0038] In yet another example of the fourth aspect, the non-aggressive skin adhesive patch comprises a hydrocolloid adhesive patch.
[0039] The fourth aspect discussed above can be provided alone or in combination with any one or more of the examples of the fourth aspect discussed above.
[0040] According to a fifth aspect, a wireless sensor patch comprises a flexible printed circuit board and at least one electronic component mounted on the flexible printed circuit board and extending from a first side of the circuit board flexible print. The wireless sensor patch additionally includes at least one electrode extending from a second side of the flexible printed circuit board and a non-aggressive adhesive skin patch mounted on a second side of the flexible printed circuit board. The at least one electrode extends through at least one through opening defined by the non-aggressive skin patch. The wireless sensor patch additionally includes an electrode insulating member positioned within the through opening defined by the non-aggressive skin adhesive patch and circumscribes the electrode to prevent contact between the electrode and the non-aggressive skin adhesive patch. The wireless sensor patch additionally includes a cover patch
13/50 flexible texture mounted in relation to the non-aggressive skin adhesive patch with the electronic component positioned within a space between the flexible cover patch and the non-aggressive skin adhesive patch.
[0041] In an example of the fifth aspect, the wireless sensor patch additionally includes a bonding layer that mounts the skin-friendly adhesive patch on the second side of the flexible printed circuit board.
[0042] In another example of the fifth aspect, the electrode extends through an opening defined by the electrode insulation member.
[0043] In yet another example of the fifth aspect, the at least one electrode includes at least a first electrode and a second electrode, where each extends from a second side of the flexible printed circuit board and each extends through the last through opening defined by the non-aggressive adhesive plaster to the skin. In one example, the electrode isolation member prevents both the first electrode and the second electrode from contacting the skin-friendly adhesive patch. In another example, the electrode insulating member includes a first opening that receives the first electrode and a second opening that receives the second electrode. In another example, the electrode insulating member is received within a single through opening defined by the non-aggressive skin patch. In yet another example, the electrode insulation member is shaped like an 8.
[0044] In an additional example of the fifth aspect, the flexible cover plaster defines a viewing port configured to allow viewing of a portion of the damping layer through the flexible cover plaster viewing port. In one example, the portion of the cushion layer includes evidence
14/50 that can be seen through the flexible cover plaster viewing port.
[0045] Still in an additional example of the fifth aspect, the flexible covering plaster has an occupation area that is larger than an occupation area of the non-aggressive adhesive plaster to the skin. In one example, an adhesive occupation area of the wireless sensor patch includes a portion of non-aggressive skin adhesive defined by the non-aggressive skin adhesive patch that is circumscribed by a peripheral adhesive portion defined by an adhesive layer of the covering patch. flexible.
[0046] In another example of the fifth aspect, the non-aggressive skin adhesive patch comprises a hydrocolloid adhesive patch.
[0047] The fifth aspect discussed above can be provided alone or in combination with any one or more of the examples of the fifth aspect discussed above.
[0048] Other features and advantages of the present invention will become apparent to those skilled in the art from the detailed description below. It should be understood, however, that the detailed description of the various specific modalities and examples, while indicating the preferred modalities and other modalities of the present invention, are provided by way of illustration and not limitation. Various changes and modifications within the scope of the present invention can be made without departing from the spirit of the same and the invention includes all such modifications.
Brief Description of the Drawings [0049] These, as well as other objectives and advantages of this invention, will be more fully understood and appreciated by referring to the following more detailed description of the preferred exemplary embodiments of the invention in conjunction with the accompanying drawings, in which:
15/50 [0050] Figure 1 is an example of an exemplificative wireless sensor patch, according to the aspects of the development, applied to a patient's skin surface;
[0051] Figure 2 is a top view of the wireless sensor patch of Figure 1;
[0052] Figure 3 is a side view of the wireless sensor patch of Figure 1;
[0053] Figure 4 is a bottom view of the wireless sensor patch of Figure 1;
[0054] Figure 5 is an exploded top perspective view of a wireless sensor patch of Figure 1;
[0055] Figure 6 is a sectional view of the wireless sensor patch along line 6-6 of Figure 5;
[0056] Figure 7 is a sectional view of the wireless sensor patch along line 7-7 of Figure 5;
[0057] Figure 8 is a bottom perspective view of a sensor device of the wireless sensor patch of Figure 5;
[0058] Figure 9 illustrates steps of the method in a method to manufacture a plurality of wireless sensor patches;
[0059] Figure 10 is a sectional view along line 10-10 of Figure 9;
[0060] Figure 11 is a view along line 11-11 of Figure 9;
[0061] Figure 12 is a sectional view along line 12-12 of Figure 9;
[0062] Figure 13 is a view along line 13-13 of Figure 9;
[0063] Figure 14 is a view along line 14-14 of Figure 9;
[0064] Figure 15 is a continuation of Figure 9 that illustrates this
16/50 additional method steps in the method to manufacture the plurality of wireless sensor patches;
[0065] Figure 16 is a sectional view along line 16-16 of Figure 15;
[0066] Figure 17 is a view along line 17-17 of Figure 15;
[0067] Figure 18 is a view along line 18-18 of Figure 15;
[0068] Figure 19 is a view along line 19-19 of Figure 15;
[0069] Figure 20 is a sectional view along line 20-20 of Figure 15;
[0070] Figure 21 is a sectional view along line 21-21 of Figure 15;
[0071] Figure 22 is a view along line 22-22 of Figure 15;
[0072] Figure 23 is a view along line 23-23 of Figure 15;
[0073] Figure 24 is a view along line 24-24 of Figure 15;
[0074] Figure 25 is a sectional view along line 25-25 of Figure 24;
[0075] Figure 26 is a continuation of Figure 15 which illustrates additional method steps in the method for fabricating the plurality of wireless sensor patches;
[0076] Figure 27 is a view along line 27-27 of Figure 26;
[0077] Figure 28 is a view along line 28-28 of Figure 26;
[0078] Figure 29 is a view along line 29-29 of Figure 26;
17/50 [0079] Figure 30 is a continuation of Figure 26 which illustrates additional method steps in the method for fabricating the plurality of wireless sensor patches;
[0080] Figure 31 is a view along line 31-31 of Figure 30;
[0081] Figure 32 is a sectional view along line 32-32 of Figure 31;
[0082] Figure 33 is a cross-sectional view of another exemplary wireless sensor patch, according to the aspects of the disclosure;
[0083] Figure 34 is a bottom view of the wireless sensor patch in Figure 33 along line 34-34 in Figure 33, where the release liner is not illustrated for clarity;
[0084] Figure 35 is a cross-sectional view of yet another exemplary wireless sensor patch, according to the aspects of the disclosure;
[0085] Figure 36 is a cross-sectional view of yet another exemplary wireless sensor patch, according to the aspects of the disclosure;
[0086] Figure 37 is a top view of the wireless sensor patch in Figure 36 along line 37-37 in Figure 36;
[0087] Figure 38 is a cross-sectional view of another exemplary wireless sensor patch, according to the aspects of the disclosure; and [0088] Figure 39 is a bottom view of the wireless sensor patch of Figure 38 along line 39-39 of Figure 38, where the release liner is not illustrated for clarity.
Detailed Description of the Invention [0089] The present invention is now illustrated in greater detail by means of the following detailed description, which represents the best
18/50 method currently known for carrying out the invention. However, it should be understood that this description should not be used to limit the present invention, but is preferably provided for the purpose of illustrating the general features of the invention.
[0090] Figure 1 illustrates a wireless sensor patch 101 according to the aspects of the present disclosure. The wireless sensor patch 101 can be designed to monitor various parameters of a patient 103. For example, as shown, the wireless sensor patch 101 can adhere to a skin surface 105 of patient 103. Any of the patch patches Wireless sensor discussed throughout the revelation can adhere to the patient's various alternative skin surfaces. For example, the skin patch can adhere to a patient's chest (for example, as shown in Figure 1), on the patient's arm (for example, behind the arm) or in various other locations of the patient depending on the circumstances.
[0091] As discussed below, the wireless sensor patch 101 can include at least one sensor configured to monitor any or a combination of parameters. For example, the sensor may comprise a Galvanic Skin Response (GSR) sensor configured to detect changes in skin resistance to electrical current due to changes in skin perspiration. The measurement of the change in skin perspiration can be designed to detect various physiological and / or psychological conditions. Additionally or alternatively, one or more Electrocardiogram (ECG) sensors can be provided to monitor the condition of the cardiac muscle in a patient. Still in the additional examples, the sensors can be designed to detect skin resources (for example, temperature, glucose levels, chemical levels, pharmaceutical substances, etc.). As such, the wireless sensor patch can have a wide range of applications. As discussed below, the plaster of
19/50 wireless skin of the present disclosure can allow comfortable application and monitoring without necessarily requiring a continuous wired connection. In addition, the wireless sensor patch can be produced at low cost, thus making the patch potentially disposable. In disposable applications, a new wireless sensor patch is provided for each application; thus avoiding costly sanitation and cleaning procedures.
[0092] The wireless sensor patch 101 may include a memory device configured to store data collected by the sensor device. Additionally or alternatively, the wireless sensor patch 101 may include a transmitter configured to transmit wireless signals 107 (for example, via Bluetooth wireless technology) that will be received by a device 109. Device 109 may be a cell phone or another receiving device that can, in turn, relay the information by satellite to another location for processing. In the additional examples, the wireless sensor patch may include a USB port or other interface to allow periodic wired connections to the wireless sensor patch. In these examples, after a period of time, the patient may temporarily provide a wired connection between the patch and device 109 (for example, via a USB cable) to provide communication between the device and the wireless sensor patch. In this way, information can be collected by device 109 continuously (for example, over a wireless connection) in real time when synchronized with device 109 and / or can be sent periodically to device 109 when the patient makes a wired connection or other direct connection between device 109 and the wireless patch. These wired or wireless connections can be used to transfer information from the wireless sensor patch to device 109 as information collected from the patient and / or information
Current 20/50 on the wireless sensor plaster. In the additional examples, the wired or wireless connection may allow information or commands to be loaded from device 109 to the wireless sensor patch. For example, commands can be loaded to change a plaster's operating condition, to provide information to be displayed by the plaster and / or other functionality.
[0093] In the additional examples, the device 109 may comprise a storage unit configured to store data that is transmitted by the wireless sensor patch 101. In the additional examples, the device 109 may comprise a processing unit configured to process the data. In yet the additional examples, device 109 can optionally transmit signals 111 configured to be received by wireless sensor patch 101. For example, device 109 can send command signals to wireless sensor patch 101 in order to change a wireless sensor patch operating condition 101.
[0094] Figure 2 is a top view of the example wireless sensor patch 101 shown in Figure 1. The wireless sensor patch 101 includes a flexible support patch 201. As shown in Figure 3, the flexible support patch 201 includes a defined thickness between a first face 301 and a second face 303. As shown in Figures 2 and 4, the flexible support plaster 201 includes an outer periphery 203 that defines an area of occupation of the flexible support plaster 201. The outer periphery 203 can comprise a wide range of shapes and sizes configured to be properly attached to the skin surface 105 of patient 103. The flexible support plaster 201 can comprise a wide range of materials configured to provide support while still providing flexibility to allow the
21/50 wireless sensor patch 101 conforms to a wide range of skin surface shapes. For example, the flexible support plaster 201 may comprise a fabric represented by the reinforced adhesion pattern illustrated in the drawings. The illustrated fabric comprises a non-woven fabric although woven fabrics can be provided in the additional examples.
[0095] As represented by the vertical lines set forth in Figure 4, the wireless sensor patch 101 may also include an adhesive layer 401 applied to the first face 301 of the flexible support patch 201. The adhesive layer may comprise a pressure sensitive adhesive such as rubber-based adhesive, acrylic adhesive or silicone adhesive that allows the patch to adhere immediately to the skin surface 105 after applying the wireless sensor patch 101. Furthermore, the wireless sensor patch 101 can comprise an adhesive patch non-aggressive skin 403 as the first and second portions of the non-aggressive skin adhesive plaster illustrated 403a, 403b mounted on the first face 301 of the flexible support plaster 201 with the adhesive layer 401. In one example, the non-aggressive skin adhesive plaster 403 may comprise a hydrocolloid adhesive patch although another non-aggressive skin patch may be provided with the integrated hydrocolloid or other adhesives that can absorb moisture. For example, the non-aggressive skin patch 403 may comprise a hydrocolloid like the hydrocolloid material disclosed in any of US Patent Nos. ² 7,335,416 issued on February 6, 2008, No. ² US 6,710,100 issued on 23 March 2004, No. ² US 6,583,220 issued on June 24, 2003, No. ² US No. 6,326,421 issued on December 4, 2001, No. ² US 12 / 866,750 deposited on August 9, 2010 and Provisional Patent No. ² US 61 / 467,553 filed on March 25, 2011, which are incorpo
22/50 in this document for reference in their entirety.
[0096] As shown in Figure 4, an outer periphery of the adhesive layer 401 can circumscribe the non-aggressive adhesive patch to the skin 403. As such, an external peripheral adherence of the wireless sensor patch 101 to the skin surface 105 of the patient 103 can be achieved. At the same time, the non-aggressive skin adhesive patch 403 can be held in place against the skin surface 105 to allow sufficient time for the non-aggressive skin adhesive patch 403 to heal into an effective adhesive member. The non-aggressive skin adhesive patch 403 allows the wireless sensor patch 101 to be applied to the skin surface for a significant period of time without irritating the skin surface when compared to the adhesive layer 401. At the same time, a relatively peripheral portion The small adhesive layer 401 may allow the peripheral portions of the patch to adhere immediately to the skin surface while allowing sufficient time for the non-aggressive skin adhesive patch 403 to heal.
[0097] Figure 5 shows an exploded view of the wireless sensor patch 101. Figure 6 is a cross-sectional view of the flexible support patch 201 showing adhesive layer 401 being applied to the first face 301 of the flexible support patch. 201. Figure 7 is a cross-sectional view of the skin non-aggressive adhesive plaster 403 along line 7-7 of Figure 5. As shown, the skin non-aggressive adhesive plaster 403 may include a flexible substrate 701 with a layer of non-aggressive skin adhesive 703 applied to a first face 705 of flexible substrate 701. In some examples, flexible substrate 701 may comprise a transparent or translucent substrate 701 to allow visualization of evidence 501 that can be printed on the surface.
23/50 second side 707 of the flexible substrate (for example, see Figures 4 and 5). In these examples, the evidence 501 can be printed in reverse, so that the information can be deciphered by viewing the evidence through the non-aggressive skin adhesive layer and the flexible substrate 701. The non-aggressive skin adhesive layer 703 can comprise a hydrocolloid adhesive or other non-aggressive skin adhesive that can facilitate adhesion to the skin surface for long periods of time with relatively low aggravation in the skin layer.
[0098] As further illustrated in Figure 5, the wireless sensor patch 101 additionally includes a sensor device 503. Figure 5 illustrates a top perspective view of an example sensor device 503, while Figure 8 illustrates a bottom perspective view of the sensor device 503 along line 8-8 of Figure 5. As shown in Figure 8, the sensor device 503 can include a pair of Galvanic Skin Response (GSR) sensor probes 801a 801b configured to interact with skin surface 105 to detect changes in skin resistance to electrical current due to changes in skin perspiration. The 503 sensor device may also include a pair of Electrocardiogram (ECG) sensor probes 803a, 803b configured to monitor the condition of the cardiac muscle in a patient.
[0099] An electronic module 805 can be provided that can receive signals from the pair of sensor probes of GSR 801a, 801b and / or the pair of ECG sensor probes 803a, 803b. In some examples, the wireless sensor patch 101 can be configured to operate only with one type of sensor, although both types of sensor can be configured to operate in the additional examples. For example, as shown in Figure 4, only the GSR sensor probes 801a, 801b extend through the support patch.
24/50 flexible contact 201 to engage the patient's skin surface. The ECG sensor probes 803a, 803b are not exposed to interact with the skin surface and / or the electronics inside the 805 electronics module can be arranged to turn off the ECG sensor and / or may not have ECG sensor functionality . Figure 5 demonstrates an example where the openings 505a, 505b are provided in the flexible support plaster 201 in addition to a central opening 507 to allow communication of the GSR sensor probes 801a, 801b and the ECG sensor probes 803a, 803b through the flexible support plaster 201.
[00100] As further shown in Figure 8, the sensor device 503 may also include identification signs 807 as a UPC code or the like to refer to the specific sensor device 503 or a type of sensor device. Referring again to Figure 5, the sensor device 503 can also include a battery 509 configured to power the sensor device 503 and a control button 510 configured to operate the sensor device. The sensor device 503 can be mounted on the second side 303 of the flexible support plaster 201, so that at least one of the sensor probes is aligned with the openings. In fact, as shown, the GSR sensor probes 801a, 801b are aligned with the central opening 507 which extends through the flexible support plaster. This alignment allows a portion of the GSR sensor probes 801a, 801b to project from the central opening 507, as shown in Figure 3. In addition, as shown in Figure 5, the ECG sensor probes 803a, 803b can be aligned to the corresponding openings 505a, 505b that extend through the flexible support plaster 201. Although not shown, a hydrogel agent or conductor can also be provided to assist in coupling the
25/50 ECG sensor 803a, 803b with the skin surface 105 through the corresponding openings 505a, 505b.
[00101] The sensor device 503 can be mounted on the second side 303 of the flexible support plaster 201 with various adhesive configurations. For example, as shown in Figure 5, adhesive in the form of a patch layer patch 511 can be provided to assist in mounting the sensor device 503 on the second face 303 of the flexible support patch 201. As shown, openings 513a , 513b can be provided in alignment with ECG sensor probes 803a, 803b to facilitate proper interaction with skin surface 105. Likewise, openings 515a, 515b can be provided in alignment with GSR sensor probes 801a, 801b to facilitate proper interaction with the skin surface 105. In some examples, the bonding layer may be transparent and / or translucent to allow identification marks 807 to be viewed from below, as shown in Figure 4.
[00102] The wireless sensor patch 101 additionally includes a flexible cover patch 517 mounted on the second face 303 of the flexible support patch 201, wherein the sensor device 503 is at least partially housed within a pocket 519 defined by at least at least one of the flexible support plaster 201 and the flexible cover plaster 517. For example, a protruding portion of the electronic module 805 can be housed within a preformed pocket 519 of the flexible cover plaster 517. In some models, the button control 510 can be activated by pressing a side portion of the flexible preformed pocket 519. The flexible cover plaster may comprise a polymeric member, such as a closed cellular foam material that can be substantially water resistant to help protect electrical components of
26/50 electronic module 805. As shown, the bonding layer plaster 511 can function to mount the flexible cover plaster 517 on the second face 303 of the flexible support plaster 201.
[00103] As further illustrated in Figure 2, the flexible cover plaster 517 includes an outer periphery 205 that defines an occupation area of the flexible cover plaster 517. As shown, in one example, the occupation area of the flexible support plaster 201 defined by the outer periphery 203 of the flexible support plaster 201 is larger than an occupation area of the flexible cover plaster 517. Providing the flexible cover plaster 517 with a larger occupation area can help prevent overlapping of the plaster periphery 205 flexible cover 517 that can provide a peeling point. As such, the wireless sensor patch 101 can be safely applied to the skin surface 105 with a reduced chance of inadvertent peeling of the wireless sensor patch 101 from the skin surface 105.
[00104] Referring to Figures 3 and 5, a release liner 305 can be provided to help prevent adhesive layer 401 and non-aggressive skin adhesive layer 703 from adhering to other surfaces and / or to prevent contamination before applying the wireless sensor patch.
[00105] The wireless sensor patch 101 shown in Figures 1 to 6 can easily be applied to the skin surface 105 of a patient 103. As shown in Figures 3 and 5, the release liner 305 can be removed initially in order to exposing the adhesive layer 401 and the non-aggressive skin adhesive layer 703, as shown in Figure 4. In addition, as shown in Figure 4, the evidence 501 can be read through the non-aggressive skin adhesive.
27/50
In addition, the evidence 807 associated with the sensor device 503 can be read through the patch layer patch 511. Then, the wireless sensor patch 101 can be applied to the skin surface 105 of a patient 103 in an appropriate location. Once applied, the outer peripheral portion of adhesive layer 401 immediately mounts the wireless sensor patch 101 in place, where, after a sufficient period of time, the non-aggressive skin adhesive layer 703 cures to provide the primary bond while reducing irritation and / or aggravation in the skin layer that may otherwise occur over long periods of time with only the relatively rough adhesive layer 401.
[00106] Various methods can be used to manufacture the wireless sensor patch 101. For example, referring to Figure 5, the method may include the step of providing the flexible support patch 201 that includes the first face 301 and the second face 303, where the outer periphery 203 defines the occupation area of the flexible support plaster 201. The method may also include providing adhesive layer 401 on the first face 301 of the flexible support plaster 201. In the additional examples, the adhesive plaster non-aggressive to skin 403 can be mounted on the first face 301 of the flexible support plaster 201 with the adhesive layer 401. In one example, the signs 501 can be printed backwards on the surface that adheres to the adhesive layer 401. As such, the evidence can be seen through the skin non-aggressive adhesive plaster 403, as shown in Figure 4.
[00107] Referring again to Figure 5, the method for fabricating the skin patch may additionally include the step of mounting the sensor device 503 on the second face 303 of the flexible support patch 201. At least one sensor probe of the device sensor can be aligned to an opening that extends through
28/50 of the flexible support plaster before mounting the sensor device on the second face of the flexible support plaster. For example, as shown in Figure 5, the GSR sensor probes 801a, 801b can be aligned to the central opening 507 of the flexible support plaster 201. Likewise, the ECG sensor probes 803a, 803b can be aligned to the openings corresponding 505a, 505b extending through the flexible support plaster 201.
[00108] The method for manufacturing may additionally include the step of mounting the flexible cover plaster 517 on the second face 303 of the flexible support plaster 201. In one example, the bonding layer plaster 511 or other adhesive can be used to mount the flexible cover plaster 517 on the second side 303 of the flexible support plaster 201. After mounting the flexible cover plaster 517, the protruding portion of the electronic module 805 is at least partially housed in the pocket 519 defined by the flexible cover plaster 517 Although not shown, additionally or alternatively, the flexible support plaster 201 may include a pocket for at least a portion of the sensor device 503.
[00109] The efficiency and speed to manufacture the wireless sensor patch can be improved by several methods to manufacture a plurality of wireless sensor patches, for example, sequentially manufacturing a plurality of wireless sensor patches.
[00110] Figure 9 illustrates a schematic view of a manufacturing apparatus 900 that demonstrates exemplary method steps for manufacturing a plurality of wireless sensor patches. The method may include the step of unrolling a non-skin adhesive membrane 901 from a non-skin adhesive membrane storage roller 903.
29/50 [00111] As shown in Figure 10, the skin non-aggressive adhesive membrane 901 may include a substrate sheet 905 that carries a layer of skin non-aggressive adhesive 907 on a first face 905a of the substrate blade 905. A substrate blade 905 will eventually be separated (e.g., cut) into the flexible substrate 701 of the non-aggressive skin patch 403 discussed above. As such, in some examples, the substrate sheet 905 may comprise a transparent or translucent substrate sheet to allow visualization of evidence 501 which can subsequently be printed on the second face 905b of the substrate sheet 905. In some examples, the substrate 905 may comprise a flexible polyurethane sheet that acts as a carrier sheet for the non-aggressive skin adhesive 907.
[00112] As discussed earlier, the non-aggressive skin adhesive membrane 901 additionally includes a non-aggressive skin adhesive layer 907 that can be carried by the first face 905a of the substrate blade 905. The non-aggressive skin adhesive layer 907 eventually will be processed into the skin non-aggressive adhesive layer 703 of the skin non-aggressive adhesive plaster 403 discussed above. As such, the non-aggressive skin adhesive layer 907 may comprise a hydrocolloid adhesive or other non-aggressive skin adhesive that can facilitate adhesion to the skin surface for long periods of time with relatively low damage to the skin layer. As further illustrated in Figure 10, the non-aggressive skin adhesive membrane 901 can additionally include a first release liner 909 carried by the non-aggressive skin adhesive layer 907. In one example, the first release liner 909 can comprise a silicone release that can protect the non-aggressive skin adhesive 907 during transportation while allowing easy removal of the release liner from contact with the
30/50 non-aggressive skin adhesive 907 in order to expose the non-aggressive skin adhesive for further processing.
[00113] The manufacturing apparatus 900 may additionally include a printing device 911 configured to print evidence 501 on the second face 905b of the substrate blade 905. As shown in Figure 11, the evidence can be printed upside down, so that the information can be deciphered by viewing the evidence through the non-aggressive skin adhesive layer and the flexible substrate through the first face 905a of the substrate slide 905. The evidence may comprise information related to the wireless sensor patch 101 such as the date of printing, the batch number and may even include identification information to allow individualized naming of each corresponding wireless sensor patch. Manufacturing apparatus 900 may also include a quality check, such as an optical reader 913 configured to check the print quality of the 501 evidence.
[00114] The manufacturing apparatus 900 may also include a pair of rollers 915 configured to flush the substrate blade 905 and non-aggressive skin adhesive 907 on the first release liner 909 to define the non-aggressive skin adhesive patch 403 shown in Figure 5. In fact, as shown in Figure 12, a roll 1201 of the pair of rollers 915 can include a cutting knife 1203 in the form of the skin-friendly adhesive plaster 403. As shown, the cutting knife 1203 is designed to work against an anvil roll 1205 to cut the substrate blade 905 and the non-aggressive skin adhesive 907 on the first release liner 909 flush through the release liner. As shown in Figure 13, the shape of the skin non-aggressive adhesive plaster 403 is cut to the face subsequently within the skin non-aggressive adhesive membrane 901. Once the cut to the face is finished, the 501 signs can be
31/50 located appropriately on the second face 707 of the flexible substrate 701 of the skin non-aggressive adhesive plaster 403.
[00115] As further illustrated in Figure 13, a plurality of first register openings 1301 can be provided by another knife of the roller pair (not shown). As shown, the first registration openings 1301 are created by a cutout removed from the substrate blade 905, the skin non-aggressive adhesive 907 and the first release liner 909 from the skin non-aggressive adhesive membrane 901. The cutout can be provided periodically along the length of the non-aggressive skin adhesive membrane 901 (for example, between each adjacent pair of non-aggressive skin adhesive patches cut to face 403 to facilitate the recording of subsequent layers of material, as discussed in more detail below.
[00116] Back to Figure 9, the manufacturing apparatus 900 may additionally include a stand 917 configured to wrap unused portions of the non-aggressive skin adhesive membrane 901 from the first release liner 909. As shown in Figure 14, non-aggressive adhesive plasters cut to the face 403 are now abandoned in the first release liner 909.
[00117] Figure 15 is a continuation of Figure 9 that illustrates additional method steps. The method may additionally include the step of unwinding a flexible support membrane 1501 from a support membrane storage roller 1503 along an assembly path. As shown in Figure 16, the flexible support membrane 1501 is provided with a layer of skin adhesive 1601 applied to a first face 1603 of a flexible support blade 1605. The layer of skin adhesive 1601 can eventually be cut into the layer of skin adhesive 401 of flexible support plaster 201 shown in Figure
32/50 and / or in Figure 6. As such, skin adhesive 1601 can comprise a contact adhesive that can quickly mount flexible support plaster 201 on a skin surface 105. Therefore, the skin adhesive layer 1601 is configured to adhere to a first face 1603 of the flexible support blade 1605, so that the skin adhesive can be configured to adhere to the first face 1603 of the flexible support blade 1605 on a skin surface 105. The blade flexible support strip 1605 can optionally be cut on flexible support plaster 201. As such, flexible support blade 1605 can comprise a fabric, such as a non-woven fabric, although other materials can be used in the additional examples.
[00118] As further illustrated in Figure 16, the flexible support membrane 1501 may additionally include a second release liner 1607 carried by the skin adhesive layer 1601, wherein the skin adhesive layer 1601 is sandwiched between the second release liner 1607 and flexible support blade 1605. The second release liner 1607 can comprise a silicone liner or another release liner configured to preserve the skin adhesive layer 1601 while processing techniques are performed, as discussed further in detail below.
[00119] The method can additionally include the step of flushing the flexible support blade 1605 and the skin adhesive layer 1601 on the second release liner 1607 to define an opening 1901 (see Figure 19) that extends through the flexible support blade 1605 and skin adhesive layer 1601. For example, as shown in Figure 15, the manufacturing apparatus 900 can also include a pair of rollers 1505 configured to cut flexible support blade 1605 and the layer on the face. of adhesive
33/50 of skin 1601 on the second release liner 1607. As shown in Figure 16, a roll 1613 of the pair of rollers 1505 can include a cutting knife 1611 in the shape of aperture 1901. As shown, cutting knife 1611 is designed to work against an anvil roll 1609 to cut the flexible support blade 1605 and the skin adhesive layer 1601 on the second release liner 1607 flush without cutting through the second release liner. Once complete, as shown in Figure 17, a peripheral cut 1701 circumscribes a central label 1703 in the shape of aperture 1901.
[00120] Additionally, as illustrated in Figure 17, a plurality of second registration openings 1705 can be provided by another knife (not shown) of the pair of rollers 1505. As shown in Figure 17, the second registration openings 1705 are created by a cutout removed from the flexible support membrane 1501. The cutout can be provided periodically along the length of the flexible support membrane to confirm registration between layers of material, as discussed in more detail below. [00121] Back to Figure 15, the manufacturing apparatus 900 can additionally include a boot 1507 configured to wrap the second release liner 1607, with the central label 1703 being carried away from the second release liner 1607 , as shown in Figure 18. As such, the second release liner 1607 is removed in order to expose the skin adhesive layer 601. As shown in Figure 19, the flexible support blade 1605 is then carried in a path towards the first release liner 909, where the skin adhesive layer 601 is laminated by rollers 1509 on the second face 707 of the flexible substrate 701 of the non-aggressive skin adhesive plaster 403.
[00122] Figure 20 is a sectional view of the flexible support blade 1605 which is mounted on the second face 707 of the flexible substrate
34/50
701 of skin non-aggressive adhesive plaster 403 through skin adhesive layer 1601. As in the other Figures, the thickness of the layers in Figure 20 are exaggerated for reasons of clarity. As further illustrated in Figure 20, the outer portions 2001 of the first release liner 909 are temporarily attached to the skin adhesive layer 1601. Once assembled, opening 1901 of flexible support blade 1605 is aligned with opening 2003 defined within a central portion of the adhesive patch not aggressive to the skin (see Figure 14).
[00123] Back to Figure 15, a 1511 sensor like the optical sensor can monitor the process to ensure proper alignment between the flexible support blade 1605 and the first release liner 909. If the proper registration is achieved, the plurality first register openings 1301 is aligned with the plurality of second register openings 1705. Sensor 1511 can determine the appropriate alignment of each corresponding pair of register openings 1301, 1705 to confirm proper registration and mounting of the flexible support blade 1605 in relation to the non-aggressive adhesive plaster to the skin 403.
[00124] As shown in Figure 15, the manufacturing apparatus 900 can additionally provide the step of unwinding a bonding layer membrane 1513 from a bonding layer membrane storage roller 1515. As shown in Figure 21, the bonding layer membrane 1513 may include bonding layer 2101 carrying a third release liner 2103. As shown further in Figures 15 and 21, manufacturing apparatus 900 may also include a pair of rollers 1517 configured to cut face bonding layer 2101 on the third release liner 2103 to define the bonding layer plaster 511 shown in Figure 5. As shown in Figure 21, a roll
35/50
2105 of the pair of roller rollers 1517 may include a cutting knife 2107 in the shape of the outer periphery of the bonding layer plaster 511. The cutting knife 2107 is designed to work against an anvil roll 2109 to cut the bonding layer flush. 2101 on the third release liner 2103 without cutting through the third release liner. At the same time, an edge cutting knife 2111 can trim an edge 2201 of the third release liner 2103 to accompany the unused portions of the bonding layer, as shown in Figure 22. As shown in Figure 23, the rest of third release liner 2103 holds the patch layer plaster 511 cut from the patch layer 2103 of the patch layer membrane 1513. The third release liner 2103 holds the patch layer 511 to be laminated by rollers 1519 on flexible support blade 1605, as shown in Figures 24 and 25. The rest of the third release liner 2103 can include periodic cutouts 2301 that can provide an alignment check, as shown in Figure 24 (for example, by an optical sensor or similar ).
[00125] Figure 26 is a continuation of Figure 15 illustrating additional method steps in the method for manufacturing the plurality of wireless sensor patches 101. Figure 26 illustrates a pair of rollers 2601 configured to cut through the die at least one opening probe through the bonding layer membrane in alignment with opening 1901. For example, as shown in the dashed lines in Figure 25, roller pair 2601 can cut GSR opening of probes 2501a, 2501b through the third release liner 2103 and the matrix layer plaster 511. Next, the method may include the step of removing the third release liner 2103 to be stored in stand 2603. Once the third release liner 2103 is removed, the plaster of the bonding layer 511 lami
36/50 nothing on the flexible support blade 1605 is exposed. Then, the first release liner 909 can be removed and stored in stand 2605. In place of the first release liner 909, a clear support substrate 2607 can be applied to the non-aggressive skin adhesive layer 907. The resulting top view is shown in Figure 27, in which the patches of the connecting layers 511 are separated in series with GSR probe openings 2501a, 2501b extending through the patches of the connecting layers 511.
[00126] Back to Figure 26, a robot 2609 can choose one of a plurality of sensor devices 503 from a source of sensor devices 2611 and can mount each sensor device 503 relative to the flexible support blade 1605 with the GSR probes 801a, 801b extending through the respective GSR probe openings 2501a, 2501b within the patch layer patch 511. A detection device, such as a camera, can view the sensor device 503 prior to placement to achieve proper positioning of the 503 sensor device, as shown in Figure 28.
[00127] The flexible covering plaster 517 can then be created and correctly positioned on the connecting layer plaster 511, as discussed with reference to Figures 26 and 29. For example, as shown in Figure 26, the method may include the step of unrolling a flexible cover membrane 2613 from a flexible cover membrane storage roller 2615. The flexible cover membrane 2613 can be heated and then a vacuum formed pocket can be generated by means of a cylinder it forms a vacuum 2617 including a plurality of cavities that can suck the heated flexible cover membrane 2613 to form the pockets 519 in the flexible cover membrane 2613. A pair of cutting rollers by the matrix 2619 can cut the plastic plasters
37/50 flexible cover 517 from flexible cover membrane 2613. Each cut flexible cover plaster 517 includes a corresponding pocket between pockets 519. The suction inside a transfer cylinder 2621 transports flexible cover plasters 517 so that they are placed in alignment in a corresponding patch layer plaster 511. In fact, as shown in Figure 29, the area of occupation of the flexible cover plaster 517 can be substantially the same or slightly greater or less than the area of occupation of the layer plaster bonding 511. Unused portions 2623 can be stored by stand 2625. In one example, transfer roller 2621 can also act to laminate flexible cover plaster 517 to bonding layer plaster 511, where the sensor device it is at least partially received in pocket 519.
[00128] As further illustrated in Figure 26, the clear support substrate 2607 can be removed from the non-aggressive skin adhesive layer 703 and stored in stand 2624. Final release liners (eg silicone release liners) can be added by release liner rollers 2626, 2627. A folding device 2629 can be provided to provide a J-fold in one of the release liner portion with the other release liner applied to the J-fold portion. as such, the release liner may comprise portions 3201a, 3201b (see Figure 32) to allow easy removal of the release liner when the wireless sensor patch is applied to the skin surface 105 of patient 103.
[00129] Figure 30 is a continuation of Figure 26 which illustrates the additional method steps in the method for manufacturing the plurality of wireless sensor patches 101. A pair of cutting rollers by the 3001 die operates to cut the flexible support blade 1605, a
38/50 layer of skin adhesive 1601 and the first and second portions 3201a, 3201b to provide the final wireless sensor patch 101 shown in Figures 31 and 32. Optionally, a carrier 3003 can carry the wireless sensor patches 101 to be tested on test station 3005. The test station 3005 can activate the wireless sensor patch (that is, by pressing the control button 510) to determine the proper functioning of the wireless sensor patch 101. If the proper function is not observed, the wireless sensor patch can be flagged as defective for later removal of the final batch of wireless sensor patches 101.
[00130] As further illustrated in Figure 30, the method can be completed with a packaging process. As shown, the carrier can transport the wireless sensor patches 101 on a base substrate 3007 that is unrolled from a storage roller 3009. A top packaging blade 3011 can be unrolled in the same way as a storage roller 3013. In Then, a sealing mechanism 3015 can periodically seal a plurality of wireless sensor patches 101 in a series of connected pockets that are subsequently separated from one another with a 3017 separation device. Once separated, the 3019 packaged devices can be stored in a 3021 storage box.
[00131] A 3023 printing device can be designed to print evidence including information related to the wireless sensor patch 101 out of the box. For example, the indicia 501 on the non-aggressive skin adhesive patch 403 and / or the indicia 807 on the sensor device 503 may contain information that corresponds to the indication information provided in a corresponding packaging that houses each wireless sensor patch. The supply
39/50 cementing the information on the package can be useful in determining information about the wireless sensor device contained within the package without having to open the package to retrieve the information from the evidence printed on the wireless sensor patch. Furthermore, once the wireless sensor device is removed from the packaging, the information is not lost with the packaging, since the equivalent evidence is also provided in the wireless sensor patch 101.
[00132] The method can also determine whether devices have been flagged as defective by test station 3005. If so, defective packaged devices 3019 can be removed before or after being separated and before entering the storage box. For example, defective packaged devices 3019 can be stored inside a defective storage box (not shown) for further processing or disposal. In addition, in some examples, the method may include the step of associating evidence from a portion of the wireless sensor patch (for example, evidence 501 and / or evidence 807) with a batch of at least one source of mounting materials used for manufacture the wireless sensor patch. As such, a person can easily cross-reference material rollers with the particular wireless sensor devices that include specific roller material. For example, the method can associate each material storage roller with the particular wireless sensor patch produced. As an example, the information associated with the wireless sensor patch can be used to determine exactly which non-aggressive membrane storage roller was used and which other material roller. In these examples, wireless sensor patches can be located quickly, which were produced from various sources of mounting materials. These
40/50 information can be useful to return certain wireless sensor patches that were produced from a defective material source.
[00133] The methods disclosed in this document provide multiple repeated steps positioned along an assembly path that can be performed periodically to sequentially produce the plurality of wireless sensor patches 101. The manufacture of sensor patches continuously from rollers of material can reduce assembly time and costs while consistently providing high quality wireless sensor patches.
[00134] The methods of disclosure can be modified to create a wide range of skin patches that have similar features, as well as features identical to the wireless sensor patch 101 discussed above. Figures 33 to 39 schematically illustrate several features of alternative wireless sensor patches that, like the wireless sensor patch 101, include features that are not necessarily scaled for clarity. For example, Figure 33 is a cross-sectional view of another exemplary wireless sensor patch 3301. The wireless sensor patch 3301 can include a flexible printed circuit board 3303 that is provided with at least one electronic component, such as plurality of illustrated electronic components 3305 (for example, packaged silicon electronic components), mounted on flexible printed circuit board 3303. Flexible circuit board 3303 is designed to allow a certain amount of bending to allow partial or complete of flexible printed circuit board 3303 to skin surface 105 of patient 103. As shown, the one or more electronic components 3305 extend from the first side of flexible printed circuit board 3303 and can be
41/50 selected according to the desired characteristics of the sensor. For example, electronic components 3305 can be provided to give the wireless sensor patch 3301 any or a combination of functional capabilities described in relation to the wireless sensor patch 101 above. In some examples, at least one electrode, such as the plurality of illustrated electrodes 3307a, 3307b, can be provided to extend from a second side of the flexible printed circuit board 3303. Various electrode configurations can be provided as an Ag electrode -AgCI with an optional electrolyte gel. One or more electrodes can be placed in operable communication with an electrical trace or other portion of an electrical circuit supported by the flexible printed circuit board substrate 3303. For example, a conductive coupling element 3309 can be used to secure electrodes 3307a , 3307b in the appropriate location of the flexible printed circuit board 3303. In some examples, conductive coupling element 3309 may comprise a conductive pressure sensitive adhesive and / or gel.
[00135] A non-aggressive adhesive skin patch 3311, similar or identical in composition to the non-aggressive skin adhesive patch 403 of the wireless sensor patch 3301 discussed above, can be mounted relative to a second side of the flexible printed circuit board 3303. For example, as shown, a bonding layer 3313 can mount the skin-friendly adhesive patch 3311 on the second side of the flexible printed circuit board 3303. The bonding layer 3313 can comprise a double-coated breathable material or can simply comprise double-sided adhesive tape.
[00136] In one example, the 3311 non-aggressive skin adhesive patch may comprise a hydrocolloid adhesive patch, although other non-aggressive skin adhesives may be provided as
42/50 integrated hydrocolloid or other adhesives that can absorb moisture. For example, the non-aggressive skin patch 3311 may comprise a hydrocolloid like the hydrocolloid material disclosed in any of US Patent Nos. ² 7,335,416 issued on February 6, 2008, No. ² US 6,710,100 issued on 23 March 2004, No. ² US 6,583,220 issued on June 24, 2003, No. ² 6,326,421 issued on December 4, 2001, Patent Application No. ² US 12 / 866,750 filed on August 9 2010 and Provisional Patent No. ² US 61 / 467,553 filed on March 25, 2011, which are incorporated in this document for reference in their entirety.
[00137] Any of the wireless sensor skin patches discussed in the invention can include a cushioning layer for patient comfort and / or to help protect the flexible printed circuit board (if provided) and / or protect other components electrical components as electrical components associated with the flexible printed circuit board. For example, as shown in Figure 33, the wireless sensor patch 3301 can additionally include a cushion layer 3315 that can help protect the flexible printed circuit board 3303 and / or associated electronics 3305 from damage. In fact, the 3315 damping layer can protect the circuit board and / or electronic components from externally applied forces (for example, impact forces) that can damage the 3301 wireless sensor patch. In addition, the 3315 damping layer it can also improve comfort for the patient using the patch or other individuals who encounter the wireless sensor patch 3301. In fact, instead of finding relatively rigid electronic components 3305, the 3315 damping layer can act as a stop protector to prevent unwanted encounters with electronic components relatively
43/50 rigid. In one example, the cushion layer 3315 may comprise a fabric represented by the reinforced adhesion pattern illustrated in the drawings. The illustrated fabric of the cushion layer 3315 comprises a non-woven fabric, although woven fabrics can be provided in the additional examples. The 3315 damping layer can also include an adhesive applied to a 3317 surface facing the electronics and the printed circuit board. For example, the surface 3317 can be provided with a pressure sensitive adhesive that can facilitate the assembly of the damping layer 3315 in place through the adhesive that mounts on the electronic components 3305, on the flexible printed circuit board 3303 and / or on the connection 3313.
[00138] The wireless sensor patch 3301 can additionally include a flexible cover patch 3319 mounted in relation to the non-aggressive skin adhesive patch 3311 with electronic component 3305 positioned within a space between the flexible cover patch 3319 and the patch non-aggressive skin adhesive 3311. As shown, the flexible cover plaster 3319 can be positioned on the cushion layer 3315, so that the protective layer 3315 is positioned so as to extend between the electronic component 3305 and the flexible cover plaster 3319. The flexible cover plaster 3319 can comprise a polymeric member, such as a closed cellular foam material that can be substantially water resistant and still breathable to help protect electrical components 3305 and flexible printed circuit board 3303.
[00139] Figure 34 is a bottom view of the wireless sensor patch 3301, in which a release liner 3321 designed to preserve the adhesive adhesive surfaces before application is not illustrated for the sake of clarity. As represented by
44/50 vertical lines set out in Figure 34, the flexible cover plaster 3319 can also include an adhesive layer 3401 designed to mount flexible cover plaster 3319 on the cushion layer 3315. The adhesive layer 3401 can comprise a pressure sensitive adhesive such as the rubber-based adhesive, acrylic adhesive or silicone adhesive that allows a peripheral adhesive portion 3403b defined by an adhesive layer 3401 of the flexible cover plaster 3319 to immediately adhere to the skin surface 105 after applying the wireless sensor plaster 3301. Furthermore, as previously mentioned, the wireless sensor patch 3301 can comprise the non-aggressive skin adhesive patch 3311.
[00140] As shown in Figure 34, the peripheral adhesive portion 3403b on an outer periphery of the adhesive layer 3401 can circumscribe a skin non-aggressive portion 3403a of the non-aggressive skin adhesive patch 3311. In fact, as is evident in Figures 33 a 39, the flexible skin patch of the wireless skin patch may have an occupation area that is larger than an occupation area of the non-aggressive skin adhesive patch. As such, each cordless skin patch of the present disclosure may include an adhesive occupation area with a non-aggressive skin patch defined by the non-aggressive skin patch that is optionally circumscribed by a peripheral adhesive portion defined by a layer adhesive of the flexible cover plaster. For example, by way of illustration, Figure 34 illustrates an adhesive occupation area of the wireless skin patch 3301 with the non-aggressive skin portion 3403a defined by the non-aggressive skin adhesive patch 3311 which is circumscribed by the peripheral adhesive portion 3403b defined by an adhesive layer 3401 of the flexible cover plaster 3319.
45/50 [00141] As such, an external peripheral adhesion of the wireless sensor patch 3301 to the skin surface 105 of patient 103 can be achieved. At the same time, the non-aggressive skin adhesive patch 3311 can be held in place against the skin surface 105 to allow the non-aggressive skin adhesive patch 3311 to heal sufficiently in an effective adhesive member. The non-aggressive skin adhesive patch 3311 allows the wireless sensor patch 3301 to be applied to the skin surface for a significant period of time without aggravating the skin surface when compared to the adhesive layer 3401. At the same time, a relatively peripheral portion The small 3403b of adhesive layer 3401 can allow the peripheral portions of the plaster to adhere immediately to the skin surface while allowing the non-aggressive skin portion 3403a of the non-aggressive skin adhesive patch 3311 to heal in sufficient time.
[00142] Figure 35 is a cross-sectional view of yet another example of a 3501 wireless sensor patch, according to additional aspects of the disclosure. Unless otherwise indicated, the wireless sensor patch 3501 may include identical or similar features discussed in relation to the wireless sensor patch 3301 discussed above and cited in Figures 33 to 34. Referring to Figures 33 to 35, the area of occupation of the wireless sensor plaster 3501 shown in Figure 35 is greater than the occupation area of the wireless sensor plaster 3301 shown in Figures 33 to 34. In these applications, the occupation areas of the non-aggressive skin adhesive patch 3311 and / or the flexible cover patch 3319 of the wireless sensor patch 3501 can be equally larger than the corresponding occupation areas of the non-aggressive skin adhesive patch and / or the flexible cover patch of the wireless sensor patch 3301. As illustrated, the occupation area of the adhesive plaster
46/50 non-aggressive to the skin can be increased with an increase in the total footprint of the wireless sensor patch to provide a non-aggressive adhesive patch to the skin that exposes a larger portion of the skin to the non-aggressive skin patch.
[00143] Figure 36 is a cross-sectional view of yet another example of a 3601 wireless sensor patch, according to the aspects of the disclosure. Unless otherwise stated, the wireless sensor patch 3601 may include identical or similar features discussed in relation to the wireless sensor patches 3301, 3501 discussed above and cited in Figures 33 to 35. However, as shown, the damping layer 3603 of the 3601 wireless sensor patch may comprise a foam cushioning material or other material that will allow the 3701 evidence (see Figure 37) to be printed on an outer surface 3604 of the 3603 cushion layer. In these examples, as shown in Figures 36 and 37, the flexible cover plaster 3605 can define a 3607 viewing port configured to allow viewing of a 3603a portion of the 3603 damping layer through the 3607 flexible cover plaster 3607 viewing port. In some examples, evidence 3701, such as identification information, can be printed on the 3603a portion of the 3603 dying and viewed through the 3607 viewport defined by the flexible cover plaster 3605. In some instances, the 3607 viewport may comprise an opening, although a translucent or transparent membrane or other viewable door may be provided in the examples additional. The flexible cover patch of any of the disclosure's exemplary wireless sensor patches may include a viewing port to allow visualization of evidence overlapping the flexible cover patch. For example, anyone
47/50 of the flexible cover patches of any of the exemplary wireless sensor patches may include a viewing port comprising an opening that allows visualization of evidence printed on a surface (for example, a damping layer surface) that , otherwise, it would be obscured by the flexible covering plaster.
[00144] Figure 38 is a cross-sectional view of yet another exemplary wireless sensor patch 3801. The wireless sensor patch 3801 may include a flexible printed circuit board 3303 which is provided with various electronic components previously described 3305. At least at least one electrode, such as the plurality of illustrated electrodes 3307a, 3307b can extend from the second side of the flexible printed circuit board 3303. As mentioned earlier, the electrodes can comprise Ag-AgCI electrodes which can optionally include electrolyte gel and can be placed in operable communication with an electrical trace or other portion of an electrical circuit supported by the flexible printed circuit board substrate 3303. For example, a conductive coupling element 3309 can be used to secure electrodes 3307a, 3307b in the appropriate location of the flexible printed circuit board 3303. For example, the coupling element contains Conductor 3309 may comprise a conductive pressure sensitive adhesive and / or gel. A non-aggressive adhesive skin patch 3803, similar or identical in composition to the non-aggressive skin adhesive plasters 403, 3311 discussed above, can be mounted in relation to the printed circuit board 3303 by means of a 3805 bonding layer. Bond 3805 can comprise the illustrated double-sided adhesive tape, although other bond layers (e.g., bond layer 3313 discussed above) can be used in the additional examples.
48/50 [00145] In any of the exemplary wireless skin patches described in the disclosure, any of the wireless skin patches that includes one or more electrodes (for example, electrodes 3307a, 3307b) may include an insulating member of optional electrode. For example, as illustrated in Figures 38 and 39, an electrode insulation member 3809 can be positioned within at least one through opening 3807. Although a single opening 3807 is shown, a plurality of openings 3807 can be provided in the additional examples, wherein at least one of the openings includes an electrode insulation member 3809. The electrode insulation member 3809 can circumscribe at least one electrode to prevent contact between the circumscribed electrode and the skin-friendly adhesive patch 3803. For example, as shown, electrode isolation member 3809 can circumscribe both electrodes 3307a, 3307b although electrode isolation member 3809 can circumscribe a single electrode or less of an entire plurality of electrodes in the additional examples. In some examples, the electrode insulation member 3809 is designed to electrically isolate electrodes 3307a, 3307b from each other or from other components. In one example, the electrode insulating member may comprise a closed cell foam, nonwoven fabric or other material configured to electrically isolate one or more of the electrodes. Electrical insulation can be particularly beneficial, since the non-aggressive skin patch 3803 tends to absorb significant levels of liquid (e.g., water) from the skin surface 105 of a patient 103 over time. The electrode insulation member 3809 can prevent direct exposure of electrodes 3307 to the non-aggressive adhesive plaster on the skin 3803, thereby preventing unwanted electrical communication (eg short-circuiting) from electrodes 3307a, 3307b that may occur from another way through
49/50 of the saturated skin non-aggressive adhesive plaster 3803.
[00146] In one example, the electrodes can extend through an opening of the electrode insulation member 3809. For example, as shown in Figure 39, the first electrode 3307a can extend through a first opening 3907a of the insulation member of electrode 3809 while the second electrode 3307b can extend through the second opening 3907b. As such, in some examples, each electrode 3307a, 3307b may extend through a single through opening 3807 of the non-aggressive skin patch 3803 while extending through corresponding openings 3907a, 3907b of the electrode insulation member 3809. In this example , the electrode insulating member 3809, therefore, can prevent both the first electrode 3307a and the second electrode 3307b from coming into contact with the skin non-aggressive adhesive plaster 3803. Isolating both electrodes can help to electrically isolate electrodes between themselves and / or other components. Although not shown, the electrode isolation member can be provided to isolate a single electrode. The isolation of a single electrode can reduce material costs, increase the surface area of non-aggressive skin adhesive available in contact with the skin while still electrically insulating the isolated electrode from the remaining electrode (s).
[00147] As further shown in Figure 39, the electrode insulation member 3809 can optionally comprise bulbous portions 3901a, 3901b that have a larger footprint than the corresponding footprint of the electrodes 3307a, 3307b to allow the insulation member electrode circumscribe each of the electrodes. In addition, a reduced neck portion 3903 can be provided between bulbous portions 3901a, 390b, so that the outer periphery 3905 of the insulating member of it
50/50 trode 3809 together with openings 3907 provide the electrode insulation member 3809 as an electrode insulation member in the shape of an 8 that has a number 8 shape. Providing the reduced neck portion 3903 allows the portions bulbous are connected to each other while still maximizing the surface area of the non-aggressive skin adhesive available to come into contact with the skin surface. In addition, the reduced neck portion can help to increase the electrical insulation properties in the area positioned between the electrodes, thereby improving the thermal insulation characteristics while maximizing the surface area of the non-aggressive skin adhesive available to contact the skin surface. Although not shown, the 3901 bulbous portions may simply comprise threads that are not connected together. In this example, a single thread can be provided around a single electrode to electrically isolate a selected electrode from the other electrode (s) and / or other components. Alternatively, a plurality of threads can be provided, for example, around each electrode to electrically isolate all electrodes from each other and / or from other components. [00148] It was established in this document its intention to rely on the doctrine of equivalents to determine and evaluate the reasonable fair scope of its invention, since it belongs to any device, system, method or article that does not deviate materially from the literal scope of invention, as defined in the following claims.

权利要求:
Claims (30)
[1]
1. Method of manufacturing a plurality of wireless sensor patches characterized by the fact that it comprises the steps of:
(I) unwinding a flexible support membrane from a support membrane storage roller along an assembly path, in which the flexible support membrane is provided with a skin adhesive configured to adhere a first face of the support membrane flexible to a skin surface;
(II) sequentially assembling a plurality of sensor devices with respect to a second face of the flexible support membrane along a longitudinal geometric axis of the assembly path; and (III) sequentially separating the flexible support membrane to provide the plurality of wireless sensor patches, wherein each wireless sensor patch includes a corresponding device from the plurality of sensor devices.
[2]
2. Method, according to claim 1, characterized by the fact that, after step (II) and before step (III), it additionally includes the steps of:
providing a plurality of flexible cover plasters; and fixing each flexible cover plaster relative to the second face of the flexible support membrane so that each of the plurality of sensor devices is at least partially housed within a pocket defined by at least one of the flexible support membrane and the corresponding flexible cover plaster.
[3]
3. Method, according to claim 2, characterizes
Petition 870170001794, of 10/01/2017, p. 4/15
2/9 due to the fact that the step of fixing each flexible cover plaster includes the steps to apply a bonding layer to the second face of the flexible support membrane and then laminate the flexible cover plaster to the second face of the membrane flexible support with the bonding layer.
[4]
4. Method according to claim 2, characterized by the fact that the step to provide the plurality of flexible cover plasters comprises the steps of:
unrolling a flexible cover membrane from a flexible cover membrane storage roller; and sequentially separating the plurality of flexible cover plasters from the flexible cover membrane.
[5]
5. Method according to claim 4, characterized in that it further comprises the step for forming a plurality of pockets in the flexible roofing membrane along a longitudinal geometric axis of the flexible roofing membrane and wherein the step for separating sequentially the plurality of flexible cover patches provides each flexible cover patch with a corresponding pocket of the pockets to house at least partially a corresponding device of the sensor devices.
[6]
6. Method according to claim 2, characterized by the fact that step (III) provides the flexible support membrane as a plurality of flexible support patches that are each provided with a corresponding flexible cover patch fixed to a second face of the flexible support plaster.
[7]
7. Method according to claim 1, characterized in that the skin patch comprises a hydrocolloid skin patch.
[8]
8. Method, according to claim 1, characterizes
Petition 870170001794, of 10/01/2017, p. 5/15
3/9 due to the fact that the skin adhesive additionally includes an adhesive layer applied to the first face of the flexible support membrane.
[9]
9. Method according to claim 8, characterized by the fact that step (I) assembles the skin adhesive in relation to the first face of the flexible support membrane with the adhesive layer.
[10]
10. Method according to claim 8, characterized by the fact that step (III) provides the flexible support membrane as a plurality of flexible support patches that are each provided with a plaster of the adhesive layer applied to a first face of the flexible support plaster.
[11]
11. Method according to claim 10, characterized by the fact that step (I) assembles the skin patch as a plurality of skin patch patches, in which at least one of the skin patch patches is mounted on the first face of the flexible support plaster with the plaster of the adhesive layer.
[12]
12. Method according to claim 1, characterized by the fact that it still comprises the step of providing evidence for a portion of each wireless sensor patch containing information that corresponds to indication information provided in a corresponding package that houses each patch wireless sensor.
[13]
13. Method according to claim 1, characterized by the fact that it further comprises the step of associating evidence from a portion of the wireless sensor patch to a batch of at least one source of mounting materials used to manufacture the patch patch. wireless sensor.
[14]
14. Wireless sensor patch characterized by the fact that it is manufactured according to the method, as defined in the
Petition 870170001794, of 10/01/2017, p. 6/15 vi nd i cation 1.
[15]
15. Method of manufacturing a plurality of wireless sensor patches characterized by the fact that it comprises the steps of:
(I) unrolling a skin adhesive membrane from a skin adhesive storage roller, in which the skin adhesive membrane includes a substrate slide that carries a layer of skin adhesive and a first release liner carried by the layer of skin adhesive, wherein the skin adhesive layer is sandwiched between the first release liner and the substrate sheet;
(II) cut the substrate sheet and the skin adhesive on the first release liner to define a skin adhesive patch;
(III) unwinding a flexible support membrane from a support membrane storage roller, wherein the flexible support membrane includes a flexible support blade with a layer of skin adhesive applied to a first face of the flexible support blade and a second release liner carried by the skin adhesive layer, wherein the skin adhesive layer is sandwiched between the second release liner and the flexible support blade;
(IV) cut the flexible support blade and the skin adhesive layer on the face in the second release liner to define a passage extending through the flexible support blade and the skin adhesive layer;
(V) remove the second release liner to expose the skin adhesive layer;
(VI) laminate the substrate sheet in relation to the flexible support blade with the skin adhesive layer of the membrane
Petition 870170001794, of 10/01/2017, p. 7/15
5/9 flexible support;
(VII) unwinding a bonding layer membrane from a bonding membrane storage roller, wherein the bonding layer membrane includes a bonding layer carrying a third release liner;
(VIII) cut the bonding layer on the third release liner flush to define a plaster bonding layer;
(IX) laminating the plaster connection layer in relation to the flexible support blade;
(X) cutting at least one probe passage through the connecting layer membrane in alignment with the passage defined during step (IV);
(XI) remove the third release liner to expose the laminated plaster connection layer in relation to the flexible support blade;
(XII) mount a sensor device in relation to the flexible support membrane with a sensor probe in alignment with corresponding passages defined during steps (IV) and (X);
(XIII) unrolling a flexible cover membrane from a flexible cover membrane storage roller;
(XIV) form a pocket inside the flexible cover membrane;
(XV) cut the flexible covering membrane to define a flexible covering patch that includes the pocket;
(XVI) laminating the flexible cover plaster in relation to the plaster connection layer, in which the sensor device is at least partially received in the pocket; and (XVII) cut the flexible support blade and the skin adhesive layer to provide a sensor patch without
Petition 870170001794, of 10/01/2017, p. 8/15
6/9 wire.
[16]
16. Method, according to claim 15, characterized by the fact that step (XVII) provides an external periphery of the skin adhesive layer that surrounds the skin adhesive plaster.
[17]
17. Method according to claim 15, characterized in that the skin patch comprises a hydrocolloid skin patch.
[18]
18. Method according to claim 15, characterized in that the flexible support membrane comprises a fabric.
[19]
19. Method according to claim 18, characterized in that the fabric comprises a non-woven fabric.
[20]
20. Method according to claim 15, characterized by the fact that step (XVII) is carried out periodically to produce sequentially a plurality of wireless sensor patches.
[21]
21. Method according to claim 15, characterized by the fact that it still comprises the step for providing evidence for a portion, wherein each wireless sensor patch contains information that corresponds to evidence information provided in a corresponding packaging that houses each wireless sensor patch.
[22]
22. Method according to claim 21, characterized in that it further comprises the step of associating evidence from a portion of the wireless sensor patch with a batch of at least one source of mounting materials used to manufacture the patch patch. wireless sensor.
[23]
23. Wireless sensor patch characterized by the fact that it is manufactured according to the method, as defined in claim 15.
Petition 870170001794, of 10/01/2017, p. 9/15
7/9
[24]
24. Method of manufacturing a plurality of wireless sensor patches characterized by the fact that it comprises the steps of:
(I) unwinding a flexible support membrane from a support membrane storage roller, wherein the flexible support membrane includes a flexible support blade with a layer of skin adhesive applied to a first face of the flexible support blade and a second release liner carried by the skin adhesive layer, wherein the skin adhesive layer is sandwiched between the second release liner and the flexible support blade;
(II) cut the flexible support blade and the skin adhesive layer on the face in the second release liner to define a passage extending through the flexible support blade and the skin adhesive layer;
(III) removing the second release liner to expose the skin adhesive layer;
(IV) laminating the substrate sheet in relation to the flexible support blade with the skin adhesive layer of the flexible support membrane;
(V) unwinding a bonding layer membrane from a bonding layer storage roller, wherein the bonding layer membrane includes a bonding layer carrying a third release liner;
(VI) cut the bonding layer on the third release liner flush to define a plaster bonding layer;
(VII) laminating the plaster connection layer in relation to the flexible support blade;
(VIII) cut at least one probe passage through the connecting layer membrane in alignment with the passage
Petition 870170001794, of 10/01/2017, p. 10/15
8/9 defined during step (II);
(IX) removing the third release liner to expose the laminated plaster connection layer in relation to the flexible support blade;
(X) mount a sensor device in relation to the flexible support membrane with a sensor probe in alignment with corresponding passages defined during steps (II) and (VIII);
(XI) unrolling a flexible cover membrane from a flexible cover membrane storage roller;
(XII) forming a pocket inside the flexible covering membrane;
(XIII) cut the flexible covering membrane to define a flexible covering patch that includes the pocket;
(XIV) laminating the flexible cover plaster in relation to the plaster connection layer, in which the sensor device is at least partially received in the pocket; and (XV) cut off the flexible support blade and the skin adhesive layer to provide a wireless sensor patch.
[25]
25. Method according to claim 24, characterized in that the flexible support membrane comprises a fabric.
[26]
26. Method according to claim 25, characterized in that the fabric comprises a non-woven fabric.
[27]
27. Method according to claim 24, characterized by the fact that step (XV) is performed periodically to produce sequentially a plurality of wireless sensor patches.
[28]
28. Method according to claim 24, characterized by the fact that it still comprises the step of providing information
Petition 870170001794, of 10/01/2017, p. 11/15
9/9 cios for a portion, where each wireless sensor patch contains information that corresponds to clues information provided in a corresponding packaging that houses each wireless sensor patch.
[29]
29. The method of claim 28, characterized by the fact that it further comprises the step of associating evidence from a portion of the wireless sensor patch with a batch of at least one source of mounting materials used to manufacture the patch patch. wireless sensor.
[30]
30. Wireless sensor patch characterized by the fact that it is manufactured according to the method, as defined in claim 24.

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同族专利:

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公开号 | 公开日

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MX2015009474A|2016-05-31|

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WO2014116816A1|2014-07-31|

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CA2898916A1|2014-07-31|

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EP2948054B1|2018-06-06|

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JP6294353B2|2018-03-14|

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CN105050495A|2015-11-11|

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CN105050495B|2020-08-07|

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EP2948054A1|2015-12-02|

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JP2016508396A|2016-03-22|

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MX350946B|2017-09-26|

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KR20150128673A|2015-11-18|

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