• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    bent network to repair defects in muscle wall. The present invention relates to a surgical implant (1) adapted to repair a defect in the muscle or tissue wall, comprising a flexible areal basic structure that defines a primary region (4) and at least one arm (6) starting from the region. primary (4) and having a free end and an end area extending to the free end. the arm (6) is folded back and fixed (eg welded, sutured or glued) at its end area to the primary region (4) of the basic structure. preferably, the basic structure (4, 6) is produced from one piece and comprises a net.
    公开号:BR112015009795B1
    申请号:R112015009795-2
    申请日:2013-10-04
    公开日:2021-06-22
    发明作者:Aida Astani-Matthies；Thorsten Deichmann；Dajana Kaiser；Andrea Hennemann；Burkhard Peters
    申请人:Johnson & Johnson Medical Gmbh；
    IPC主号:
    专利说明:

    [001] The invention relates to a surgical implant adapted to repair a defect in the tissue or muscle wall, in particular to repair an inguinal hernia, and to a method of manufacturing such an implant.
    [002] Inguinal hernia repair is one of the most commonly performed surgical procedures. Various prosthetic materials, typically porous to allow tissue ingrowth, have been provided in a variety of combinations, shapes and formats. Inguinal hernia repair is often achieved by inserting a plug into the hernia defect. Various materials were discussed for use as prosthetic plugs. Polypropylene is most often used in the form of a mesh net fabric to create the desired shapes.
    [003] Many commercially available plugs comprise an outer wrap (usually produced from mesh material) with a separate "charge" material attached to the interior of the outer wrap. The charge serves as a way to hold and position the plug during a surgical procedure. In addition, the load, in conjunction with the outer wrapping, allows for tissue ingrowth to occur over time.
    [004] EP 0 614 650 A2 discloses an implantable prosthesis for muscle or tissue wall repairs comprising a network of polypropylene mesh monofilaments. An outer wrap produced from the mesh material is similar to a cone (with grooves). In addition, multiple inner layers of mesh material are provided, which are located on the outer wrap and are attached to the tip area of the cone configuration. A similar implant is known from W0 97/45068 A1.
    [005] CN 101112335 A describes a multi-use embedding portion for repairing external hernias, comprising a substrate and a plurality of petals arranged on the upper surface of the substrate. The distal ends of the petals are free, while the proximal ends are fixed to the center of the substrate. A plurality of reinforcing ribs may be disposed on the upper surface of the substrate.
    [006] EP 0 888 756 A2 discloses a surgical implant for hernioplasty produced from polypropylene mesh material, in which an areal base and a protrusion serving as a plug are joined by stitches.
    [007] US 6,616,685 B shows an implant for repairing a defect in the wall of muscle or tissue, which comprises a plurality of petals, which are connected to each other at a common point defining the center of the implant. Since the petals are flexible, the implant is able to adapt to a tissue defect when it is inserted into it, and some of the petals can serve as a loading material.
    [008] In general, separate manufacturing steps are required to secure the cargo to the interior of the outer wrap. Eliminating the filling material would be a way of simplifying manufacturing; however, this would also eliminate the benefits and functionality of having a filler material.
    [009] It is the object of the invention to provide a surgical implant adapted to repair a tissue or muscle wall defect, which has the advantages of prior art implants discussed above, but which can be manufactured in an easier and cheaper way.
    [0010] This objective is achieved by a surgical implant having the features in accordance with claim 1. Advantageous versions of the implant comprise the dependent claims. Claim 18 relates to a kit comprising such an implant plus a separate surgical net. Claim 19 relates to a method for making such an implant.
    [0011] The surgical implant according to the invention is adapted to repair a tissue or muscle wall defect, in particular an inguinal hernia. The implant (implantable prosthesis, plug) comprises a flexible areal base structure, which defines a primary region and at least one arm starting in the primary region and having a free end and an end area extending to the free end. The arm is folded back and secured at its end area to the primary region of the basic structure.
    [0012] The term "bending backwards" is to be understood in a general sense. This does not imply the presence of a fold line, but rather means that the arm is led back to the primary region, for example, in a smoothly curved shape or a loop, so that it can be fixed or attached to the region. primary. In this way, the arm forms a three-dimensional structure that serves as a load or part of a load.
    [0013] In advantageous embodiments of the invention, a plurality of arms starts from the primary region. In this way, the primary region is generally located in the central area of the basic structure, and the arms form a kind of three-dimensional load. Arms can be different lengths. It is also possible that at least one additional arm starts from the primary region and is not attached to the primary region. The implant may be rotatably symmetrical with respect to rotations by an angle α about an axis running transversely through the primary region, where n^α = 360° and n > 2. Preferably, this axis of rotation runs perpendicularly with respect to a plane generally aligned parallel to the primary region of the basic structure.
    [0014] In general, the implant according to the invention can be optimized in size and shape, depending on the application in question. The areas at the ends of the arms, after flexion, can be easily attached to the primary region of the basic structure, for example, by welding, suturing and/or bonding, for example, in a central area, in a peripheral area or in a intermediate area between the central area and the peripheral area of the primary region. It is possible to fix different arms at different distances from the center of the primary region. By varying the size and shape of the primary region, the size, length and shape of the arms, the number of arms or the position where a respective arm is attached to the primary region, the implant can be designed in many different ways. The arms folded backwards serve as a load, which fills the defect to be repaired by the implant and facilitates handling during surgery since the implant can be used as a load using a gripping instrument.
    [0015] In advantageous embodiments of the invention, the basic structure comprises a network. The basic structure can also comprise a composite structure, in which at least one additional layer is added to the net, for example a film.
    [0016] The network of the basic structure is preferably macroporous with typical pore dimensions of more than 0.5 mm, which supports good tissue integration. However, other pore sizes are also conceivable. The net can be provided in any type known in the art, for example, warp net or weft net or crochet net or weft. A design like a film or perforated sheet is also conceivable. Any filaments in the net can be bioabsorbable or non-absorbable, depending on the material. Filaments can be designed as monofilaments or as multifilaments. Tape yarns and pulled film tapes are also conceivable. Any blends, blends or composites of materials and designs are also possible. Furthermore, the filaments can be coated.
    [0017] Examples for non-absorbable materials are polypropylene ("Prolene") as well as blends of polyvinylidene fluoride and vinylidene fluoride and hexafluoropropene copolymers ("Pronova"). Examples for absorbable materials are copolymers of glycolide and lactide (in particular, in the 90:10 ratio, "Vicryl"), poly-p-dioxanone ("PDS"), and copolymers of glycolide and ε-caprolactone ("Monocryl"). The designations indicated are trademarks used by the Claimant. Other materials suitable for use with surgical implants are also known in the art.
    [0018] Examples for nets comprised in the basic structure are "Vypro" and "Vypro II" nets (containing multifilaments of "Vicryl" and polypropylene), "Ultrapro" nets (containing monofilaments of "Monocryl" and polypropylene) and nets " Prolene" soft (containing polypropylene). Again, the designations indicated are trademarks used by the Claimant.
    [0019] As already mentioned, one or more additional layers can be added to the network to make it a composite structure. Additional layers can include, for example, bioabsorbable films, non-absorbable films, and/or oxidized regenerated cellulose. Through a film, for example, tissue ingrowth can be controlled, and a film can serve as a barrier to adhesion and as a means for tissue separation. For example, the basic structure web can be covered on one or both sides with a polymeric film structure, which is absorbable or permanent and can further provide a barrier to adhesion.
    [0020] Examples for networks that have an additional film layer are "Physiomesh" networks and "Proceed" networks; these designations are trademarks used by the Applicant. If a "Proceed" mesh comprising an oxidized regenerated cellulose (ORC) layer is used, the ORC layer should be placed over the outer face of the implant, ie, the face that first contacts the body tissue.
    [0021] In advantageous embodiments of the invention, the basic structure is produced from a piece, for example, from a pre-cut mesh or composite structure. It is also acceptable, however, that the arm or arms and the primary region of the basic structure are formed from separate parts, with the arm or arms being fixed to the material of the primary region in a first step and thereafter folded back and fixed in a second step. In general, it is possible that the material or structure of the basic structure will vary across its area, depending on the location of the area in question on the implant.
    [0022] The primary region of the basic structure may comprise a permanent curvature, for example, formed as a dome-like bulge. Such a curvature or dome-like bulge stabilizes the primary region. It is preferably provided in the central area of the primary region and can be done through thermoforming. The thermoforming process can result in a hardening of the material so that the bulge is able to prevent a gripping instrument from penetrating the basic structure. The term "dome-like" is to be understood in a general sense, which includes curved as well as flat profiles (eg trapezoidal) as seen in a longitudinal section of the bulge. The bulge profile must be atraumatic in order to prevent injury when inserting the implant during surgery.
    [0023] In advantageous embodiments of the surgical implant according to the invention, at least one reinforcement element is fixed to the basic structure.
    [0024] For example, a reinforcing element may be formed as a film strip or a film strip structure of resorbable poly-p-dioxanone ("PDS") material, which is laminated to the basic structure. Ribs or a rib structure are also conceivable, a rib being generally less flat than a strip. Preferably, the reinforcement elements are flexible and are fixed to the sheet of the basic structure early in the manufacturing process. Another suitable material for the reinforcing elements is Poliglecaprone 25 ("Monocryl"). If the reinforcement elements are produced from resorbable material, they can disintegrate and leave a more flexible or softer residual implant.
    [0025] Reinforcing elements strengthen and harden the implant where necessary. For example, reinforcement elements arranged concentrically with respect to a center of the primary region and/or arranged radially with respect to a center of the primary region can be laminated on one of the faces of the basic structure (for example, on its outer face , where "outside" refers to the three-dimensional shape after flexing the arms) to provide enhanced resilience to the properties of the plug to better fit the implant to the margins of the defect. Additionally, through the use of reinforcement elements fixed to the basic structure, the grip and handling of the implant with an instrument for placement and positioning can be facilitated. Simultaneously, the reinforcement elements can also operate as a penetration shield that prevents the surgeon's instrument from penetrating through, for example, the macroporous network of the basic structure, which could lead to damage to the surrounding tissue.
    [0026] Furthermore, the reinforcement elements or at least one of the reinforcement elements can be colored. In this way, the visibility of the implant as a whole in the area of surgery can be enhanced, the implant can be more easily oriented, and the handle and overall handling of the implant can be facilitated. For example, the central area of the implant can be marked by colored reinforcement elements. A suitable colorant is, for example, D&C violet No. 2.
    [0027] Overall, the surgical implant according to the invention provides many advantages. It can easily be produced at relatively low costs, for example as a light weight structure with low foreign body sensation and with little or no chronic pain, yet still having sufficient strength. During surgery, the implant only requires minimal manipulation of the anatomical structures and, as a rule, no pre-peritoneal mobilization. Compared to traditional plugging techniques (according to Rutkow), little training is required to work with the implant. Deployment tends to be quick and positioning easy. The back-folded arms provide convenient grasping and handling for placement and placement of the implant into the defect using a surgical instrument, where the instrument tip tends to be protected from penetration into the implant and causing injury. Generally speaking, the volume of the defect is filled by the implant, which is flexible. Depending on the desired application and the materials used, the implant can be fully or partially biodegradable.
    [0028] Surgical implant can be used to repair defects of different sizes. It is possible to fix the implant on the margins of the defect, for example by suturing, in which the longer arms (larger loops) can, in general, be manipulated more easily. Generally speaking, the implant can be used in the preperitoneal space as well as the intraperitoneal space (abdomen). Other possible uses refer to the repair of ventral hernia defects, umbilical and incisional hernia defects, etc..
    [0029] Some surgeons prefer to place, after inserting the surgical implant described so far, into a hernia defect, a piece of a separate surgical mesh over the implant or body tissue in the area of the implant, respectively. To this end, a kit is provided which comprises a surgical implant as described above plus a separate surgical mesh which is adapted to be placed over the tissue or muscle wall defect after the surgical implant has been applied. This separate surgical net can be pre-shaped to a suitable size and/or can be trimmed to the desired size if necessary. Preferably, the material of the separate surgical mesh is the same as a mesh in the basic structure. The separate surgical network can also comprise a composite structure.
    [0030] In a method of manufacturing a surgical implant according to the invention, a flexible basic structure is provided and the arm or arms are folded back and fixed, in its or its end areas, to the primary region of the basic structure , for example, by welding, suturing or gluing.
    [0031] In the following, the invention is described in more detail through examples. The drawings show in
    [0032] Figure 1 in parts (a), (b), (c) and (d) several views of a surgical implant modality according to the invention, that is, in part (a) a plan view of a structure basic, in part (b) the basic structure after the formation of a protrusion in its central area, in part (c) a longitudinal section through the protrusion and in part (d) a three-dimensional view of the implant after the flexion of the basic structure,
    [0033] Figure 2 is a three-dimensional view of a variant of the embodiment of Figure 1, comprising reinforcement elements,
    [0034] Figure 3 is a three-dimensional view of another variant of the embodiment of Figure 1, comprising arms having different lengths,
    [0035] Figure 4 in parts (a), (b) and (c) several views of another modality of the surgical implant according to the invention, that is, in part (a) a plan view of a basic structure, in the part (b) a three-dimensional view of the implant after flexing a variant of the basic structure and in part (c) a three-dimensional view after additionally forming the implant and
    [0036] Figure 5 in parts (a) and (b) views of another modality of surgical implant according to the invention, that is, in part (a) a plan view of a basic structure and in part (b) a three-dimensional view of the implant after flexing the basic structure.
    [0037] Figure 1 illustrates a first modality of a surgical implant, which is designated by reference number 1.
    [0038] In Figure 1(a), a basic structure 2 is shown in plan view. The basic structure 2 comprises a primary region 4 in its central area and a total of eight arms 6 starting from the periphery 8 of the primary region 4. Each arm 6 has a free end 10 and, adjacent to its free end 10, an end area. 11.
    [0039] The basic structure 2 is areal, that is, produced from a relatively thin and flexible material. In the modality, it comprises a surgical mesh, eg a "Vypro II" mesh (see above), which includes multifilaments of "Vicryl" (absorbable) and polypropylene (non-absorbable). Furthermore, in the modality, the basic structure 2 is produced from a piece, for example, through die cutting.
    [0040] Figure 1(b) shows the basic structure 2 after a protrusion 12 has been formed in the central area of the primary region 4. Figure 1(c) shows the protrusion 12 in longitudinal section in a plane perpendicular to the plane of Figure 1(b) and runs through the center of the basic structure 2. In modality, the protrusion 12 has an elliptical curvature and is atraumatic, that is, it is designed as a low-profile tip. It is formed by thermoset, which results in a stiffening effect in the central area of the basic structure 2 and stabilizes the primary region 4 of the implant 1. The protrusion 12 facilitates the handling of the implant 1 during surgery, it may prevent a tip of a gripping instrument penetrates the basic structure 2 and causes injuries, and minimizes an irritation of the peritoneum.
    [0041] Figure 1(d) illustrates how the three-dimensional shape of implant 1 is formed. For this purpose, the arms 6 are bent back towards the primary region 4, as indicated by the arrows, and the end area 11 of the arms is fixed to the primary region, for example, by ultrasonic welding, suturing or gluing (by example, with the use of poly-p-dioxanone as a glue). (To be precise, Figure 1(d) is related to a slight variant of the basic structure 2 of Figures 1(a) and (1b), in which the arms 6 are slightly wider.) The bulge 12 is not visible in the Figure 1(d); it extends to the underside, that is, in the opposite direction of the arms 6.
    [0042] Figure 2 shows a variant of the implant 1 of Figure 1, which is designated as 1'. Otherwise, like reference numbers are used as in Figure 1.
    [0043] The implant 1' is reinforced and stiffened by reinforcement elements fixed to the outer face of the basic structure 2 visible in Figure 2. In the modality, the reinforcement elements comprise a circular reinforcement band 14, which surrounds the protrusion 12, and bands gussets 16 which extend along part of each arm 6. They are cut from a blank poly-p-dioxanone block piece and welded to the basic structure before the arms 6 are bent. An increase in implant rigidity facilitates its placement during surgery. Poly-p-dioxanone is absorbable so that after some time the stiffness imposed by the reinforcing elements disappears. Reinforcement elements can be colored in order to improve the visibility of the implant during surgery.
    [0044] Figure 3 shows another variant of the implant 1 of Figure 1, which is designated as 1". Otherwise, like reference numbers are used as in Figure 1.
    [0045] In implant 1", each second arm 6" is longer than the other arms 6, so that after bending the arm backward and fixing its end areas to the primary region 4, the loops formed by the 6" arms are larger than the loops formed by the arms 6. When, during surgery, the implant 1" is to be secured to body tissue by suture, the loops of the arms 6" can preferably be used for access to the sutures.
    [0046] In the finished implants 1, 1' and 1", as shown in Figures 1(d), 2 and 3, the arms 6 and 6' form loops and act together as a plug that can be easily grasped in a surgical procedure and inserted into the defect to be repaired.
    [0047] Another modality of a surgical implant, designated by number 20, is illustrated in Figure 4.
    [0048] Figure 4(a) is a plan view of the basic structure 22, which is cut in one piece from the mesh material. The basic structure 22 defines a primary region 24 and a total of five arms 26, which are separated by cut lines 27. Since the basic structure is circular and the arms 27 are only separated by cut lines 27, the free ends 28 of arms 27 are defined by the line of circumference of the circle. After backward flexion, however, each arm is fixed to the primary region 24 in a small peripheral area 29 only.
    [0049] Figure 4(b) shows the result for the shape of the implant after the back flexion of the arms and attachment to the primary region. The implant of Figure 4(b) is a variant of the implant 20 and designated by the number 20' as it comprises only four arms 26' instead of five. Furthermore, the curvature of the cut lines between the arms 26' is mirror-like compared to the curvature of the cut lines 27 in Figure 4(a). The arms 26' can be wrapped over the internal parts of the implant 20', which results in the appearance shown in Figure 4(c).
    [0050] Figure 5 shows another modality of surgical implant, here designated by the number 30.
    [0051] The implant 30 comprises a basic circular structure32, see Figure 5(a). Its primary region 34 is reinforced by a circular reinforcement band 35 consisting, in the modality, of poly-p-dioxanone. Three arms 36 are separated by curved cut lines 37. On the inner parts of the cut lines 37, the arms are stiffened by radial reinforcement strips 38, which are penetrated by the cut lines 37.
    [0052] Initializing from the state shown in Figure 5(a), the arms 36 are bent back towards the primary region 34 and are attached, by means of the end areas 39, to the primary region 34. For this purpose, the Poly-p-dioxanone material of circular reinforcement strip 35 is used as a melt adhesive.
    [0053] Figure 5(b) shows the three-dimensional shape of the implant30. As with other implants, the loops formed by the arms can be pressed when the implant is inserted into a hernia defect.
    [0054] Many examples for suitable materials and compositions of the basic structure, including composite structures, have already been given additionally above.
    权利要求:
    Claims (15)
    [0001]
    1. Surgical implant adapted to repair a defect in the muscle or tissue wall, comprising a flexible, areal basic structure (2; 22; 32) comprising a network defining a primary region (4; 24; 34) and at least one arm (6; 6"; 26; 26'; 36) starting from the primary region (4; 24; 34) and having a free end (10; 28) and an end area (11; 29; 39) extending to the free end (10; 28), characterized by the fact that the arm (6; 6"; 26; 26'; 36) is folded back and fixed, at its end area (11; 29; 39), to the primary region (4; 24; 34) of the basic structure (2; 22; 32) to form a three-dimensional looped structure to fill a tissue or muscle wall defect to be repaired by the implant.
    [0002]
    2. Surgical implant, according to claim 1, characterized by the fact that a plurality of arms (6; 6; 26; 26'; 36) starts from the primary region (4; 24; 34).
    [0003]
    3. Surgical implant, according to claim 2, characterized by the fact that at least two arms (6, 6") have a different length.
    [0004]
    4. Surgical implant according to claim 2 or 3, characterized in that the implant (1; 1'; 1"; 20; 20'; 30) is symmetrically swiveling with respect to rotations by an angle α around an axis running transversely through the primary region (4; 24; 34), where n^α = 360° and n > 2.
    [0005]
    5. Surgical implant, according to claim 1, characterized by the fact that the network comprises at least one of the properties included in the following list: being macroporous, comprising a warp network, comprising a weft network, comprising a crochet net, comprising a woven cloth, comprising a perforated film, comprising bioabsorbable filaments, comprising non-absorbable filaments, comprising monofilaments, comprising multifilaments, comprising tape yarns, comprising drawn-film tapes.
    [0006]
    6. Surgical implant according to claim 1 or 5, characterized in that the network comprises at least one of the materials selected from the following list: polypropylene, poly-p-dioxanone, glycolide and lactide copolymers, 90:10 ratio glycolide and lactide copolymers, glycolide and ε-caprolactone copolymers, polyvinylidene fluoride blends and vinylidene fluoride and hexafluoropropene copolymers.
    [0007]
    7. Surgical implant, according to any one of claims 1, 5 or 6, characterized in that the basic structure (2; 22; 32) comprises a composite structure, in which at least one additional layer is added to the network, preferably wherein the at least one additional layer comprises a film, wherein the film comprises at least one of the properties included in the following list: being bioabsorbable, being non-absorbable, comprising oxidized regenerated cellulose.
    [0008]
    8. Surgical implant, according to any one of claims 1 to 7, characterized in that the basic structure (2; 22; 32) is produced from one piece.
    [0009]
    9. Surgical implant, according to any one of claims 1 to 8, characterized in that the primary region (4) of the basic structure (2) comprises a permanent curvature (12), preferably in which the curvature is formed as a dome-like bulge (12).
    [0010]
    10. Surgical implant, according to claim 9, characterized in that the protuberance (12) comprises at least one of the following properties: being thermoformed, having a curved or flat longitudinal profile, being located in the central area of the primary region.
    [0011]
    11. Surgical implant according to any one of claims 1 to 10, characterized by the fact that the at least one arm (6; 6"; 26; 26'; 36) in its extremity area (11; 29; 39), is attached to the primary region (4; 24; 34) in one of the areas of the primary region (4; 24; 34) and in one of the ways included in the following list: central area soldier, peripheral area soldier, soldier in intermediate area between central area and peripheral area, sutured in central area, sutured in peripheral area, sutured in intermediate area between central area and peripheral area, glued in central area, glued in peripheral area, glued in intermediate area between the central area and the peripheral area.
    [0012]
    12. Surgical implant according to any one of claims 1 to 11, characterized in that at least one reinforcement element (14, 16; 35, 38) fixed to the basic structure (2; 32), preferably in which at least one reinforcing element (14, 16; 35, 38) comprises at least one of the properties included in the following list: produced as a film, formed as a strip, formed as a rib, arranged concentrically with respect to the center of the region primary (4; 34), arranged radially with respect to a center of the primary region (4; 34), laminated to the basic structure (2; 32), being absorbable, produced from poly-p-dioxanone, produced from a copolymer of glycolide and ε-caprolactone, colored.
    [0013]
    13. Surgical implant, according to any one of claims 1 to 12, characterized by the fact that at least one additional arm starting from the primary region that is not attached to the primary region.
    [0014]
    14. Kit, characterized in that it comprises a surgical implant as defined in any one of claims 1 to 13, and a separate surgical mesh adapted to be placed over the top of the defect in the muscle wall or tissue after surgical implant (1; 1'; 1"; 20; 20'; 30) has been applied.
    [0015]
    15. Method of manufacturing a surgical implant, having the characteristics defined in claim 1, characterized in that it comprises the steps of providing a flexible basic structure (2; 22; 32) comprising a network that defines a primary region (4; 24; 34) and at least one arm (6; 6"; 26; 26'; 36) starting from the primary region (4; 24; 34) and having a free end (10; 28) and an end area (11; 29; 39) extending to the free end (10; 28), and flexes at least one arm (6; 6"; 26; 26'; 36) backwards and secures it in its end area (11; 29; 39), to the primary region (4; 24; 34) of the basic structure (2; 22; 32) to form a three-dimensional looped structure.
    类似技术:
    公开号 | 公开日 | 专利标题
    BR112015009795B1|2021-06-22|SURGICAL IMPLANT ADAPTED TO REPAIR A MUSCLE OR TISSUE WALL DEFECT, KIT AND METHOD OF MANUFACTURING A SURGICAL IMPLANT
    BR112015003206B1|2021-06-22|SURGICAL IMPLANT ADAPTED TO REPAIR A TISSUE OR MUSCLE WALL DEFECT, KIT AND METHOD OF MANUFACTURING A SURGICAL IMPLANT
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    ES2336266T3|2010-04-09|IMPLANTABLE PROTESIS.
    BR112015022927B1|2022-01-11|SURGICAL IMPLANT
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    同族专利:
    公开号 | 公开日
    CA2890123C|2021-09-21|
    CN104755044B|2017-10-13|
    IN2015DN02399A|2015-09-04|
    EP2914206B1|2017-07-12|
    US10357350B2|2019-07-23|
    JP6254175B2|2017-12-27|
    RU2625292C2|2017-07-12|
    IL237861D0|2015-05-31|
    MX2015005524A|2015-08-05|
    JP2016503314A|2016-02-04|
    CA2890123A1|2014-05-08|
    EP2914206A1|2015-09-09|
    WO2014067608A1|2014-05-08|
    KR102223246B1|2021-03-08|
    BR112015009795A2|2017-07-11|
    KR20150122118A|2015-10-30|
    AU2013339821B2|2017-11-23|
    US20140128891A1|2014-05-08|
    CN104755044A|2015-07-01|
    AU2013339821A1|2015-04-30|
    ES2640317T3|2017-11-02|
    RU2015120742A|2016-12-27|
    DE102012021547A1|2014-05-08|
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    法律状态:
    2018-11-21| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-11-12| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2021-04-06| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-06-22| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/10/2013, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    DE102012021547.9|2012-11-02|
    DE102012021547.9A|DE102012021547A1|2012-11-02|2012-11-02|Surgical implant|
    PCT/EP2013/002986|WO2014067608A1|2012-11-02|2013-10-04|Folded mesh for repair of muscle wall defect|
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