• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Instrument for taking a tissue sample through a working channel (3) of an endoscope (2) with a flexible shaft (1), the instrument (6) comprising a receiving element (8) at the distal end of a flexible shaft control tube (7) with which the recording element (8) can be brought via the working channel (3) of the endoscope (2) to the place where the tissue sample is to be taken and with which the recording element (8) can be manipulated for the taking the tissue sample, characterized in that the receiving element is composed of a spiral (10) which is coaxially rotatable and slidably guided in a cylindrical external cannula (12) with an outer diameter of maximum 5mm and that the receiving element (8) is so flexible that it can be bent in its axial longitudinal direction.
    公开号:BE1028019A9
    申请号:E20205167
    申请日:2020-03-10
    公开日:2021-09-08
    发明作者:Jacques Philibert Janssens
    申请人:Jacques Philibert Janssens；
    IPC主号:
    专利说明:

    ; BE2020/5167 9 Instrument for taking a tissue sample and using it in an endoscope with a flexible shaft. The present invention relates to an instrument for taking a tissue sample, for example for taking a tissue sample from the lungs. 9 Instruments for performing biopsy are already known | id consisting of, on the one hand, an outer rigid tube having a cutting edge at its distal end, and, on the other hand, a rigid needle which is fitted slidably and rotatably in the outer tube and which is provided at its distal end with a cutting spiral which the tissue to be sampled can be twisted like a corkscrew, the outer tube is then rotated over the coil until the coil is contained in the outer tube and then retracted into the outer tube to pass a tissue sample through the cutting edge of the sample. cutting off the outer tube and then pulling the instrument out of the body together with the tissue sample. Such an instrument is known, for example, from the EP
    No. 1,352,848 and from EP 2,623,036 by the same inventor, Taking a tissue sample in a targeted place in the body is difficult, especially for organs such as the lungs, intestines and gynecological organs that are constantly in motion.
    | _ BE2020/5167 2 | Today, devices have already been developed in the | shape of sen chotized endosccop with a flexible shaft 9 containing a working channel intended for medical | to insert instruments of a different nature at a precise location, for example to take a tissue sample, 9 An example of such a device is the robotised | bronchoscope with a flexible shaft of approximately 1 m in length and with a working channel of 2.1 mm diameter and a camera and a light source at the distal end.
    To use this device, first a CT/MRI scan of the patient is made, after which the anatomy of the bronchial tree, i.e. the bean-shaped structure of the airways, is calculated and mapped via a computer and the coordinates are determined of the place where you want to take a tissue sample from the lungs.
    The device computer-controlled ensures that the bronchoscope is sent via the mouth and the airways to the place that has been brought into coordinates on the CT scan. The fiexible shaft of the bronchoscope follows the irregular shape of the airways into the lungs. Subsequently, a flexible instrument for taking a Weelsei sample or the like can be inserted through the working channel of the bronchoscope to take a tissue sample.
    | _ BE2020/5167 3 which can be recovered for further research by withdrawing the instrument, | Due to the erratic shape of the airways, the bronchicocp : B is designed to allow the distal end of the Iflexible 9 shaft to make a 180° bend with a 9 mm radius of curvature in order to approach the upper airways. It goes without saying that the tissue sample taking instrument must be able to follow the tortuous shape of the working channel of the bronchoscope and, in extremis, possibly be able to make the 180” bend at a 9 mm radius at the end without having to penetrate the inner wall of the working channel. damage and Levens must provide a tissue sample that is sufficient to be able to carry out all further diagnostics {histoilogy, molecular biology, etc.} Currently there are no such instruments for taking a tissue sample that meet the needs of the bronchoscope and that allow efficient recovery of a sufficient size wels ess sample.
    An existing instrument is the FleZNeedle® consisting of a flexible sheath with a sliding string inside it, with a recording element in the form of a rigid hollow needle at the distal end. is pushed to push the needle into the tissue and to draw out some fluid,
    | | BE2020/5167 However, the problem is that due to the flexibility and axial | compressibility of the string there is little pressure on the tissue to be sampled: tissue can be sampled, that the sample | only fluid is {cytology} and not a solid piece of tissue and that furthermore no tissue sample of sufficient size can be taken. There are also flexible catheters with a rigid tube at the distal end having a sliding rod with a lateral recess in it to accommodate tissue.
    However, such catheters are not suitable for the intended application because insufficient force can be applied distally, so that the rod as well as the tube cannot be pushed into the tissues because the back pressure is greater than the compression on the flexible shaft and that the shaft powders. so that the tolerance to the working channel is lost. Moreover, these instruments also only provide a very limited tissue sample because the space in the hollow catheter is largely occupied by the rod.
    It is an object of the invention to develop an instrument suitable for use in a bronchoscope or other flexible endoscopic device having a working channel such as a hysteroscope, laryngosccop, iaparoscope, gastroscope or the like, in which a balance has to be sought between a number of
    ; conflicting requirements to develop a sample of sufficient size that the instrument must meet, namely: 9 - flexibility versus transfer of pressure and/or torque 9 needed to penetrate the tissue: | 5 - length of the instrument versus pressure and/cf torque; 9 - small dimensions versus quality and size of the 9 fabric sample; | - forces and sharpness versus the risk of damaging the working channel of the endoscope; LE - cost price, To this end, the invention relates to an instrument for taking a tissue tray through a working channel of an endoscope having a flexible shaft, the instrument comprising a recording element at the distal end of a flexible actuating tube with which the recording element can be brought via the working channel of the endoscope to the place where the tissue sample is to be taken and with which the recording element can be manipulated to take the tissue sample, characterized in that the recording element is composed of a spiral which is coaxially rotatable and slidable cell in a cylindrical external cannula has an outer diameter of maximum 5 mm and that the receiving element is made so flexible that it can be bent in its axial longitudinal direction and this without significant loss of torque or compression force, is one advantage of the invention that the receiving element itself is flexible in that both the external cannula and the spiral are flexible, this in contrast to
    { BE2020/5167 the known applications, and therefore the inclusion element | can follow a bend in the working channel of the endoscope. 9 Before taking a tissue sample, there should be no pressure | 3 can be applied to the co-receiving element as the 9 coil pulls itself into the tissue # by the application of a torque, whereby, by anchoring the coil in 9 the tissue, the cutting cannula , rather than through single | pressure, is rotated by pulling up and pressure in the tissue. 9 10 This anchoring at least halves the compressive force required to cut the fabric sample. Due to the rotational movement of the coil, only a fraction of longitudinal pressure is required here as this is converted into a partial rotational and longitudinal pressure. cut along the outside of the spiral, so that a sufficiently large and high-quality tissue sample can be taken with a length and a diameter corresponding to the length of, for example, 1 to 2 cm of the spireal and a diameter of, for example 1 mm, preferably it is receiving element is flexible in such a way that it can be bent into a bend with a radius of curvature of at least S3mm on the inside of the bend.
    In this way it can be used, for example, in the most difficult anatomical configurations.
    The outer cannula may be surrounded by a coating or | protective sleeve so as not to damage the working channel and to facilitate sliding, | Since the extreme miniaturization of the bicpsie 9 instrument according to the invention imposes requirements on the F material, the recording element is preferably made 9 in a flexible non-magnetic autenitic medical 9 stainless steel Z21LCR-6Ni-9Mn which is, for example, also made | 10 used for stents.
    According to a practical embodiment, the cannula is flexible by providing the cannula in a central part over a certain length with successive groove patterns in the axial length of the central part, each of two segment-shaped grooves which are in line with each other at the same distance from the ends of the cannula extending transversely and separated from each other by two diametrically opposed bridges of residual material.
    Such a pattern can nowadays be performed with great precision and with small dimensions by laser cutting, for example in the aforementioned steel grade,
    The length of the remaining bridges between the slots is preferably about 3 to 5% of the circumference of the cannula, preferably about 4%. This means for an outer diameter of the cannula of 1.6 mm, for example, a length of the remaining bridges from 0.15mm to 0.25nm, preferably 0.2mm.
    { Such narrow bridges in combination with narrow slots | with a width of e.g. 2.1 mm and a 9 spacing between the successive slot patterns of 9 & e.g. 0.1 mm provide sufficient flexibility of the cannula for application in a bronchoscope through a 9 sourt of gimbal action with vital elasticity of { the material.
    The cardan configuration ensures maximum transmission of torque and the flexible but few #19 compressible bridges ensure maximum transmission of thrust.
    Preferably, the axially successive slot patterns are rotated relative to each other through a certain angle of, for example, about 60° or 90" about the geometric axis of the cannula.
    Due to the succession of wave patterns, the cannula can actually be made as long as desired, but given the cost price, in practice a length of 1 to Z cn is sufficient for taking a high-quality tissue sample with a stiff section at the ends and a central section. having said slot pattern, wherein the rigid portion at the distal end is provided with a cutting edge.
    For twisting and retracting the coil into the cannula, the receiver element is connected to a flexible delivery tube which is preferably tubular in design with an outer flexible sheath in which an inner flexible tube or coil is axially slidable and slidable.
    | rotatably mounted 18, with the cannula of the | recording element is attached to the distal end of the 9 sheath and in its extension and the spiral of the | receptacle is attached to the inner hose or coil. 9 The control is preferably done by a manipulator at the 9 prozimal end of the control hose, whereby the | manipulator allows to twist and retract the inner tube or coil to rotate the coil of the pickup element from the cannula into the tissue egg to be sampled and retract back into the cannula to cut a tissue sample and collect it into the sample member to take,
    The proximal end of the operating lead cover is preferably of a certain length, so that less torque is lost in this part when a tissue sample is taken. After all, this end must not be able to be bent for use in a bronchoscope or other endoscopic device.
    When inserting the instrument into the working channel of the endoscope, it is preferable to run a plastic wire through the actuating tube beyond the distal end of the receptacle so that the wire protrudes forward from the receptacle by one end, protruding end ensures good guidance of the recording element in the working channel of the endoscope and thus prevents damage to the endoscope
    : BE2020/5167 inner wall of the working channel through the cutting edge of the cannula. | To take the fabric sample, the thread is then pulled back {5, at least beyond the spiral of the 9 receiving element.
    According to a particular aspect, the wire is a solid core wire which is slidable to fit in the coil of the take-up element 10 and which is retracted during withdrawal of the coil from the take-up element into the cannula for taking the tissue sample so as to to develop additional suction that aids in loosening the tissue sample and provides greater assurance that the tissue sample will not be lost en route when withdrawing from the working channel.
    The solid core wire can also incorporate other different functions such as the protection against the working channel; facilitate punctures to guide the helix afterwards; a sensor Devangen to detect molecules; contain a camera, contain active elements for treatment such as radical frequency conductors, hyperthermia, local chemo/immunotherapy and/or the application of fiduciary markers, The construction of the instrument allows cok to pass a wire with a fiduciary marker through the instrument to behind it For example, at the place where a tumor in the lung should be irradiated.
    il ; Thanks to this marker, the tumor can be irradiated much accurately by focusing on the marker and the movements of | to also have the tumor tracked over time, which means that many | less surrounding tissue is damaged. The invention also relates to the use of an instrument according to the invention for use in an endoscope with a working channel diameter of 2.1 mm which must allow the recording element to take passing a fabric sample through the working channel at a bend of the working channel of 180° with a radius of curvature of 2 rem.
    In order to better demonstrate the features of the invention, by way of example without any limiting character, a preferred embodiment of an instrument according to the invention for taking tissue samples through the working channel of a flexible endoscope is described below, with reference to the accompanying drawings, in which: figure 1 schematically represents the shaft of a flexible endoscope provided with an instrument according to the invention for taking a tissue sample; Figure 2 represents a view according to arrow F2 in Figure 1; Figure 3 represents the instrument of Figure 1 but this is only from the shaft of the flexible endoscope and 38 with a manipulator in dashed line;
    | figure à on a larger scale the recording element tcont | as indicated by the box Fd at the distal 9 end of the instrument of figure 3: [ figure 5 in perspective and on a larger scale the | 5 spiral Pays as indicated by arrow F5 in figure 4, 9 but in loose condition; 9 figure © shows a side view of the coil of 9 figure 5; 9 figure 7 shows on a larger scale a front view of the tip of the spiral according to arrow F7 in figure 6; figure € shows on a larger scale a section according to Line VITII-VIII in figure 3; figure % shows in perspective and on a larger scale the cannula indicated by F3 in figure 4, but in loose condition; Figure 10 is a side view of the cannula of Figure 3; Fig. 11 shows on a larger scale the portion shown in Fig. 10 with the frame Fil i8; Figures 12 to represent cross-sections, respectively, along lines XII-MII, XIII-XIII and XIV-XIV of Figure 11; Figure 15 shows a view of a central portion of the cannula of Figure 5 but sectioned along line XV-XV in Figure 9 and then opened in a flat plane; figure 16 shows an application. Pays off when using the instrument according to the invention:
    { BE2020/5167 13 figure 17 shows a test set-up for the | testing the flexibility and flexibility of the {opnane element. Figure 1 shows the flexible shaft 1 of a | endoscope 2, for example of a bronchoscope 2 with an internal working channel 3 with diameter A of maximum 5 mm. 9 The shaft 1 has a length of at least 70 cm and contains 9 10 at its distal end a hyperflexible part la which is inserted through the anatomical structures up to the target and which must be able to be bent through 180° with a radius of curvature of 9 mm as shown in broken line in figure 1, this in order to be able to reach a tumor or the like in the highest branches of the most capricious anatomical structures.
    The tip of the flexible shaft 1 is in this case equipped with a camera and a light source 5, Figure 1 is shown with an instrument according to the invention as shown separately in Figure 3 for taking a tissue sample.
    The instrument 5 comprises a flexible operating tube 7 having at its distal end a receiving element 8 for receiving a tissue sample and at the proximal end a manipulator 3, which is shown here only schematically as a frame and which is intended for the interventionist to to be able to manipulate the recording element from outside the patient's body for taking
    | sen tissue sample at the distal end of the shaft 1 { of the endoscope 2. | The operating tube 7 with the receiving element 9 & at its end is pushed into the working channel 3 of the endoscope 9 as far as the distal end of the endoscope 2 | to be able to take a tissue sample Le there and sen 9 has a length that is greater than the length of the flexible shaft | L of the endoscope 2, The control tube 7 is the Length divided into different parts with, for example, respectively a Rigid proximal part 7a of e.g. Scm for attachment to the manipulator, a proximal rigid part 7b of e.g. 30 cm that fits into a rigid part of the shaft 1, a flexible part 7c of, for example, 40 cm, a hyperfiexible part 70 of, for example, 30 cm and finally the cpname element 8 with a length B between 0.8 and 2 cm and an outer diameter C that is smaller than 2 mm and is so flexible that it can be bent in its axial longitudinal direction in all radial directions in order to be pushed through a bend of the working channel 3 of 180” with a radius of 3 nm without damaging the working channel 3.
    The receiving element 8 is composed of a coil 10 with a cutting tip 11 which is coaxially rotatable and slidably guided in a substantially cylindrical external cannula 12 having a distal end with a cutting edge 13 as shown in Figure 4 in which the coil 10 is already partially protrudes from the cannula 12.
    ; 15 | Both cannula 12 and coil 10 are flexible, at | preferably elastically flexible so that they always return to their original shape without load 9 9 The coil 10 and the cannula 12 are, for example, made 9 of non-magnetic autenitic medical stainless steel 9 2lCR-SNi-9Mn, known from the medical field for manufacturing stents or the like.
    For example, the cannula 12 has an outer diameter C of about 1.6 mm and an inner diameter D of about 1.4 mm.
    The cannula 12 is in this case made flexible by providing the cannula 12 in a central portion 12a over a certain length E with groove patterns 14 successive in the axial length of the central portion at an axial distance F from each other as shown in the figures. 11 and 15.
    Blk slot pattern 14 is formed by two segment-shaped slots 15 which extend in line in the transverse direction and which are separated from each other by two diametrically opposite bridges 16 of residual material.
    In the example of the figures, the slots 15 have a diameter G which is approximately equal to the position F between successive wave patterns measured in the axial direction, and is, for example, equal to 0.08 to 0.15 mm, preferably
    : BE2020/5167 : 156 approximately equal to 0.1 mm.
    The cutting pattern of the slots preferably has an isocentric configuration. The pattern of the slots 15 may differ along the length E95.
    Thus, the slots 15 may be wider in the most distal portion relative to the most proximal portion, for example to increase flexibility.
    The length H of the remaining bridges 16 between the slots 15 is about 3 to 5% of the circumference of the cannula 12, preferably about 4%, and thus, for an outer diameter C of the cannula of 1.6 mm, a length of the remaining bridges 16 from 0.15 mm to 0.25 mm, preferably 0.2 mn for an outer diameter C of 1.6 mm, 15 The slot patterns 14 successive in axial direction are rotated relative to each other by approximately 60° about the geometric axis of the cannula 12 as shown in the cross-sections of figures 12 to 14 for three successive slit patterns 14. The twist of slit patterns 14 should not necessarily be 60° but may be at a different angle.
    An example of this is shown in Figures 18 to 20 for a 30° twist of the bridges 16 of successive slot patterns 14. In this case, when the cannula 12 is bent downward in the plane of Figure 18 as shown in Figure 21, then the diametrically opposite bridges 16 that are located in the middle in figure 18 come into service
    | BE2020/5167 17 { as hinges which together in pairs define a hinge axis X-X° { Perpendicular to the plane of figure 18 as | shown in figure 19, where the slots 15 of the | concerning slot pattern 14 at the bottom close | 3 while the slots 15 at the top open as 9 shown in figure 21. 9 when in the same way the cannula 12 is bent out of 9 the plane of figure 18, the bridges 16 at the top and id at the bottom will act as hinges and pivot axes together in pairs. Define YY' oriented perpendicular to the plane of Figure 18 as shown in Figure
    20. In this way, successive pivot axes X-X' and YY are formed that are perpendicular to each other, much like a quasi universal joint which forms a torque-transmitting coupling between two rotating shafts that are not necessarily aligned relative to each other.
    The universal joint of the cannula 12 has the properties of being able to transmit rotational movement without loss of torque as well as the bridges 16 being flexible and flexible.
    Both the cannula 12 and the coil are made of a material that is not only flexible but also flexible such as, for example, but not limited to, allcoins having these properties or other materials with analogous characteristics,
    ; 18 The axial length E of the central portion 12a is 9 for example 7 mm or greater. | The intersections of the bridges 16 are isocentric, i.e. perpendicular to the tube, and therefore not parallel | diagonally on the tube). This greatly simplifies the | production process and also maximizes the cardan action of | the bridges. 9 10 The Stable spiral 10 has an outer diameter I that is slightly | is less than the inner diameter D of the cannula 12 with a clearance DI that is less than one tenth of a millimeter,
    The spiral is hollow and in the example has an inner diameter J between 0.5 and 3.5 mm, preferably an inner diameter J between 0.9 and 1.5 mm, in the example the pitch of the spiral 10 is approximately the millimeter and the axial width L of the turns is about half the pitch K,
    As shown in the cross-section of figure 7, the fiexible control hose 7 is of double tubular design with a
    253 outer flexible tubular sheath 17 in which an inner flexible tube or coil 18 is slidably and rotatably mounted, the cannula 12 of the receiving element 8 being attached to the distal end of the sheath 17 and in extension thereof and the coil 10 of the receiving element 8 is attached to the inner hose or coil 18 of the operating hose.
    | BE2020/5167 19 | With the manipulator 9, the inner tube or coil 18 { in the sheath 17 can be rotated and displaced in order to thus remove the spiral 10 of the receiving element 8 from the cannula 12 | in the tissue to be sampled like a corkscrew and then together with the gripped tissue | retracting into the cannula 12 by rotating the cannula 12 9 and pulling Le over the coil 10, then cutting a cylindrical tissue sample 9 through the cutting edge 13 9 from the cannula 12 and into the receiving element 9 10 8 The tissue sample can then be recovered by withdrawing the operating tube 7 of the instrument 6 from the working channel 3 of the endoscope 2 .
    According to a particular aspect, the sheath 17 and/or inner tube 16 may be formed as a medical steel tube formed fiexible over at least part of its length by corrugated or serrated cuts extending substantially in the longitudinal direction of the tube as described. In a previous patent application by the same inventor, the spiral 10 of the receiving element 8 and the inner hose or spiral 18 of the operating hose 7 preferably have the same or substantially the same inner diameter, so that a continuous channel 19 is created in which, for example, a solid-core plastic wire 20 can fit. are made to a length that allows the wire 20 to pass through this channel to or beyond the distal end of the capture element 8 as shown in Fig. 16, projecting forward. end of the wire 20 provides better guidance of the recording element 8 in the working channel 3 of the 9 endoscope 2 in order to prevent damage to the inner wall of this working channel 3. If the wire 20 fits in the channel 19 is made, the wire 40 can also help to create a vaculm in the receiving device by retraction, which can help to dislodge the tissue sample and prevent the tissue seistasis from sliding out of the receiving end when withdrawing from the shaft 1 of the endoscope. element would come loose. In addition, the wire can help to push the obtained tissue out of the spiral.
    The application of an instrument 6 according to the invention is, of course, not limited to an endoscope such as the bronchoscopic tube, but can also be used for less flexible endoscopes with a larger inner diameter of the working channel, in which case the flexible recording element 8 also has a larger outer diameter. can have, for example up to 5 mm. With regard to the flexibility of a receiving element € as described and dimensioned above, a test was carried out as illustrated in figure 17, whereby the receiving element 8 in question was passed through by means of a pull wire 21 the receiving element 8 was bent around a mandrel 22 with a diameter M of 18 mm, it being found that for this purpose a small tensile force N of less than ZN was sufficient to bend the receiving element.
    ; 21 | with a radius of curvature of 9 mm. The test allows Loe to quantitatively compare the î flexibility of different slot patterns.
    The present invention is by no means limited to the 9 embodiment described as an example and shown in the figures, but an instrument according to the invention 9 can be realized in all kinds of shapes and dimensions without departing from the scope of the invention. 19
    权利要求:
    Claims (1)
    [1]
    à BE2020/5167 22 Conciuses.
    : Ll.- Instrument for taking a tissue sample via a working channel (3) of an endoscope (2) with a flexible shaft (1), the instrument (6) being provided with a recording element (8 ) at the distal end of a flexible operating tube {%} with which the recording element (8) can be brought via the working channel {3} of the endoscope {2} to the location where the tissue sample is to be taken and with which the co-receiver element is {8} can be manipulated to take the tissue sample, characterized in that the receiving element is composed of a spiral {109 which is coaxially rotatable and slidably guided in a cylindrical external cannula {12} with an outer diameter of maximum 55mm and that the receiving element (8) is so flexible that it can be bent in its axial longitudinal direction.
    Instrument according to claim 1, characterized in that the coname element (8) can be bent into a bend with a radius of curvature of at least 3mm on the inside of the bend,
    3.7 Instrument according to claim 1 or 2, characterized in that the receiving element (8) is flexible in all radial directions to form a bend,
    Instrument according to one of the preceding claims, characterized in that the coil {10} and the cannula (1 )
    | be made of non-magnetic autenitic medical [ stainless steel Z21CR-6Ni-93Mn. { 3.- Instrument according to one of the preceding claims, characterized in that the receiving element (58) is 0.8 to 2 cm long in axial direction, 9 6.- Instrument according to one of the preceding claims, | characterized in that the outer diameter (C) of the 9 19 c receiving sheet element {8} is smaller than Z2mm.
    Instrument according to one of the preceding claims, characterized in that the outer cannula {12} of the receiving element {8} has an outer diameter (C} of approximately 1.6 mm and an inner diameter (D) of approximately 1 .4 mm.
    Instrument according to one of the preceding claims, characterized in that the cannula {12} is flexible by providing the cannula {12} in a central part =0 {12a} cover with a certain length (E) in the axial length of the central portion (12a) successive groove patterns (14) of in each case two segment-shaped grooves {1} extending in line in transverse direction and which are separated from each other by two diametrically opposed bridges {16} of residual material.
    Instrument according to claim 8, characterized in that the length of the remaining bridges (16) between the slots (15) is approximately 3 to 5% of the outer circumference of the cannula {12}, preferably approximately 46, and thus for a
    / outer diameter (C) of the cannula (12) of 1.6 mm a length 9 of the remaining bridges (16) of 0.15 mm to 0.25 mm, preferably 0.2 mm for an outer diameter (CC) of 1 , 6mm.
    | 10. Instrument according to claim 8 or 3, characterized in that the consecutive # slot patterns {14} in the axial direction are rotated relative to each other 9 in the cannula (12).
    Instrument according to claim 10, characterized in that the successive groove patterns (14) in the axial direction are rotated about 60” or 90° about the geometric axis of the cannula {12}.
    12.7 Instrument according to one of claims 8 to 11, characterized in that the width (G) of the grooves and the axis (F) between successive groove patterns (14) measured in the axial direction are approximately equal or differ according to flexibility of the most distal portion of the instrument.
    Instrument according to one of claims 8 to 12, characterized in that the distance (F) between successive groove patterns (14) measured in the axial direction is approximately equal to 2.8 to 0.15 mm, preferably approximately 0.1 brake. Instrument according to any one of claims 8 to 13, characterized in that the axial length (E) of the central portion (12a) provided with successive groove patterns is greater than 7 mm.
    ; 15. instrument according to one of the preceding claims, | characterized in that the distal end of the cannula 9 (12) is provided with a cutting edge (13). | 5
    Instrument according to one of the preceding claims, characterized in that the spiral (10) of the receiving element (8) has an outer diameter (I) which is slightly smaller than the inner diameter (D) of the cannula ( 17) with a | LG clearance that is less than one tenth of a millimeter,
    Instrument according to one of the preceding claims, characterized in that the coil (10) has an inner diameter {3} between 0.5 and 3.5 mm, preferably between 0.9 and 1.5 mm.
    Instrument according to one of the preceding claims, characterized in that the spiral (10) has a pitch (EK) of approximately one millimeter and with an axial width (L) of the turns of approximately half the pitch ( K}, 19. Instrument according to any one of the preceding claims, characterized in that the flexible actuating hose (7) is tubular with an outer flexible sheath (17) in which an inner flexible hose or spiral (18) is arranged axially slidably and rotatably. wherein the cannula (12) of the receiving element {8} is attached to the distal end of the sheath {17} and in its extension and the coil (10) of the receiving element (8) is attached to the inner tube or spiral {18}.
    ; mn BE2020/5167 26 | 20. Instrument according to claim 19, characterized in: | that it has a | . at its proximal end manipulator (9) that controls the inner snake or spiral {18} | 5 in the sheath (18) can be rotated and shifted about the coil (10) of the sensor element (8) from the cannula | {12} into the tissue to be sampled and pull back 9 the cannula {12} to cut off a tissue sample 9 and insert it into the recording element (8), 2i. Instrument according to claim 19 or 20 , characterized in that the prozimal end of operating hose {7} is rigid over a certain length.
    Instrument according to one of Claims 13 to 21, characterized in that the inner and/or outer tube {17,18} is at least partly constructed as a medical steel tube which is flexibly designed over at least part of its length by corrugated or serrated cuts extending mainly in the longitudinal direction of the pipe,
    Instrument according to any one of claims 19 to 22, characterized in that the coil (10) of the receiving element (8) and the inner tube or coil (18) of the actuating tube (7) have the same or substantially the same inner diameter. . Instrument according to any one of claims 19 to 23, characterized in that the length of the operating hose {7} is greater than 70 cm.
    | 27
    25.7 Instrument according to claim 23 or 24, thereby | characterized in that it is provided with a solid core wire (20): which is slidable to fit in the spiral (10) of the retaining element (83) and has a length that allows the wire 9 to pass through the inner hose or spiral (18) to 9 at or beyond the distal end of the instrument Thus, Use of an instrument according to any one of the preceding claims for use in an endoscope (2) with an internal diameter (A) of the working channel (3) of 2.1 mm, which must allow to pass the receiving element (B) for taking a tissue sample through the working channel (3) at a bend of the working channel (3) of 180° with a radius of curvature of % mm.
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    同族专利:
    公开号 | 公开日
    BE1028018A1|2021-08-20|
    BE1028019B9|2021-09-13|
    BE1028018B1|2021-08-24|
    BE1028019B1|2021-08-24|
    BE1028019A1|2021-08-20|
    引用文献:
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    BE1013974A3|2001-02-16|2003-01-14|Janssens Jacques Phillibert|Device for taking a tissue language.|
    EP2670311A1|2011-01-31|2013-12-11|Boston Scientific Scimed, Inc.|Distal tip configurations for biopsy with eus fna|
    JP2012235878A|2011-05-11|2012-12-06|Terumo Corp|Biopsy device|
    BE1020378A3|2012-02-01|2013-08-06|Jacques Philibert Janssens|INSTRUMENT FOR TAKING A TISSUE STEEL.|
    WO2015073675A1|2013-11-15|2015-05-21|Boston Scientific Scimed, Inc.|Needle biopsy systems|
    CA2950805A1|2014-06-10|2015-12-17|Charles WALTHER|Endoscopic biopsy instrument|
    KR102007998B1|2017-02-28|2019-08-07|안용철|Biopsy device|
    法律状态:
    2021-09-30| FG| Patent granted|Effective date: 20210824 |
    优先权:
    申请号 | 申请日 | 专利标题
    BE20205054A|BE1028018B1|2020-01-29|2020-01-29|Instrument for taking a tissue sample and using it in an endoscope with a flexible shaft|
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