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    • 专利摘要:
    Wart pen for treating warts, comprising: - a cartridge housing in which a gas cartridge is at least partially accommodated, which gas cartridge comprises a coolant under elevated pressure; - a dosing device with a coolant passage and provided with one or more housings, which dosing device is suitable for being attached to the cartridge housing by means of a distal side, which dosing device is provided on a proximal side with an applicator for applying low temperatures to one or more a plurality of warts to be treated, which dosing device comprises a perforator, distal to the applicator, which is adapted to puncture the gas cartridge, and which dosing device is provided with a valve body between the applicator and the perforator for closing and / or opening the coolant passage ; - a closure cap adapted to be removably positioned on and attached to the proximal side of the dosing device; wherein the cartridge housing and / or at least one housing of the dosing device are made from a plastic reinforced with glass fibers.
    公开号:BE1022740B1
    申请号:E2015/5341
    申请日:2015-06-03
    公开日:2016-08-25
    发明作者:Bart Rossel
    申请人:Oystershell Nv；
    IPC主号:
    专利说明:

    WRATTENPEN AND METHOD FOR OPERATING ONE
    WRATTENPEN
    TECHNICAL DOMAIN
    The invention relates to a wart pen for the treatment of warts and a method for operating a wart pen.
    BACKGROUND ART
    A wart pen for the treatment of warts, which is suitable for home use, is known from EP 2 468 204, in the form of a self-contained, disposable, cryosurgical pen comprising a cryogenic liquid, such as a stream of liquid nitrous oxide (N2O) , carbon dioxide or argon. The cryogenic liquid is either applied directly to a surface to be treated, for example a wart on the skin, or delivered to an applicator which is then brought into contact with the surface to be treated. In addition, the pin includes at least one filter that is placed in the flow passage and is configured to facilitate the flow of cryogenic fluid. EP 2 468 204 shows a problem that the construction of the disclosed wart pens gives rise to a relatively high cost price of the wart pens.
    In addition, EP 2 468 204 poses the problem that the pen cannot produce the required low temperatures for a sufficiently long period of time necessary for the treatment of warts. In particular, the required low temperatures can be achieved by the pin of EP 2 468 204, but not for a sufficiently long period of time.
    It is an object of the present invention to find a solution to the above problems.
    In particular, the present invention contemplates a wart pen for the treatment of warts, suitable for home use, which is low in cost and yet sufficiently strong, and in addition can provide the required temperature-time conditions that are necessary for an efficient treatment of warts.
    SUMMARY OF THE INVENTION
    A first aspect of the invention relates to a wart pen for treating warts, comprising: - a cartridge housing 1 in which a gas cartridge 2 is at least partially accommodated, which gas cartridge 2 comprises a coolant under elevated pressure; - a dosing device with a coolant passage and provided with one or more housings 3, 4, 6, 10, which dosing device is suitable for being attached to the cartridge housing 1 by means of a distal side, which dosing device is provided on an proximal side with an applicator 7 for administering low temperatures to one or more warts to be treated, which dosing device comprises, relative to the applicator 7, a perforator 5 adapted to puncture the gas cartridge 2, and which dosing device is provided between the applicator 7 and the perforator 5 is of a valve body for closing and / or opening the coolant passage; - a closure cap 11 adapted * to be removably positioned on and attached to the proximal side of the dosing device; wherein the cartridge housing 1 and / or at least one housing 3, 4, 6, 10 of the dosing device are made from a plastic reinforced with glass fibers.
    Plastic reinforced with glass fibers is a strong material with a light weight that is cheaper than high-quality lightweight materials such as aluminum and carbon fiber.
    A second aspect of the invention relates to a method for operating a wart pen, the method comprising the steps of: - providing a wart pen for treating warts, the wart pen comprising: a cartridge housing 1 in which a gas cartridge 2 is at least partially accommodated, which gas cartridge 2 comprises a coolant under elevated pressure; a dosing device with a coolant passage, which dosing device is suitable for being attached to the cartridge housing 1 by means of a distal side, which dosing device is provided on a proximal side with an applicator 7 provided with an application surface for administering low temperatures to one or more treat warts, which dosing device comprises a perforator 5 distal to the applicator 7, which perforator is adapted to puncture the gas cartridge 2, and which doser device is provided between the applicator 7 and the perforator 5 with a valve body for closing and / or opening the 1 coolant passage; a closure cap 11 adapted to be removably positioned on and attached to the proximal side of the dispenser; - operating the valve body; - applying the applicator 7 to one or more warts; wherein to operate the valve body, the closure cap 11 is attached to the proximal side of the dispensing device, and the closure cap 11 is removed after operating the valve body.
    The attachment of the closure cap 11 on the proximal side of the dosing device shields the applicator 7 from the environment, so that during operation of the valve body the applicator 7 can be cooled faster by evaporative cooling of the coolant at the level of the applicator 7 than when the closure cap 11 would not be attached to the proximal side of the dosing device.
    A third aspect of the invention relates to a use of a method according to the present invention for operating a wart pen according to the present invention.
    DESCRIPTION OF THE FIGURES
    Figure 1 is an exploded view of a possible embodiment of a wart pen according to the present invention.
    Figure 2 is a longitudinal sectional view of a possible embodiment of a wart pen according to the present invention.
    Figure 3 is a longitudinal sectional view of a possible embodiment of a wart pen according to the present invention.
    Figure 4 shows a section in the longitudinal direction in addition to a three-dimensional representation of a possible embodiment of a housing 6 according to the present invention.
    Figure 5 is a side view of a possible embodiment of a housing frame according to the present invention.
    Figure 6 shows a longitudinal section alongside a three-dimensional representation of a possible embodiment of a cartridge housing 1 according to the present invention. . Figure 7 is a cross-sectional view of a possible embodiment of a closure cap 11 according to the present invention.
    Figure 8 shows a possible embodiment of a housing 10 according to the present invention.
    Figure 9 shows a temperature versus time graph for experiments using possible embodiments of a wart pen according to the present invention.
    Figure 10 shows a temperature versus time graph for experiments using possible embodiments of a wart pen according to the present invention.
    Figure 11 shows a temperature versus time graph for experiments using possible embodiments of a wart pen according to the present invention.
    DETAILED DESCRIPTION
    Unless defined otherwise, all terms used in the description of the invention, including technical and scientific terms, have the meaning as generally understood by those skilled in the art of the invention.
    The terms "comprises", "comprising", "provided with", and "includes" are synonyms and are inclusive or open terms indicating the presence of what follows, and which do not exclude or prevent the presence of other components, features, elements , members, steps, known from or described in the prior art.
    The citation of numerical intervals by the end points includes all integer fractions and / or real numbers between the end points, including these end points.
    A first aspect of the invention includes a watten pen for the treatment of warts, comprising: - a cartridge housing 1 in which a gas cartridge 2 is at least partially accommodated, which gas cartridge 2 comprises a coolant under increased pressure; - a dosing device with a coolant passage and provided with one or more housings 3, 4, 6,10, which dosing device is suitable for being attached to the cartridge housing 1 by means of a distal side, which dosing device is provided on a proximal side with a 7 for administering low temperatures to one or more warts to be treated, which dosing device comprises, relative to the applicator 7, a perforator 5 adapted to puncture the gas cartridge 2, and which dosing device is provided between the applicator 7 and the perforator 5 of a valve body for closing and / or opening the coolant passage; - a closure cap 11 adapted to be removably positioned on and attached to the proximal side of the dosing device; wherein the cartridge housing 1 and / or at least one housing 3, 4, 6, 10 are made of the dosing device -of a plastic-reinforced with glass fibers.
    The wart pen of the present invention is suitable for the treatment of warts by the low temperatures, preferably lower than -65 ° C, more preferably lower than -70 ° C and most preferably lower than -95 ° C, which at the applicator 7 of the wart pen can be reached. These low temperatures are generated when a liquid coolant, with a low boiling point, preferably lower than 10 ° C, more preferably lower than 0 ° C, even more preferably lower than -50 ° C and most preferably lower than -85 ° C, rapidly evaporated at the applicator 7 at ambient temperature or at the body temperature of a human body. The heat required for the evaporation of the liquid coolant is withdrawn from the applicator 7, so that this applicator 7 cools to low temperatures. In other words, the applicator 7 is cooled to low temperatures by evaporative cooling. The use of an applicator 7 cooled to a low temperature on one or more warts ensures the destruction of the one or more warts by destroying cells. The evaporative cooling obtained reaches temperatures sufficiently low for the treatment of warts, preferably a temperature lower than -60 ° C, more preferably a temperature lower than -70 ° C and most preferably a temperature lower than -75 ° C C, without causing hypothermia and / or without unwanted interaction of the low temperatures with surfaces that do not require treatment, such as, for example, healthy skin tissue that penetrates warts. Various dermatological conditions in addition to warts, such as, for example, age spots and fibroids, can also be treated by applying the obtained evaporative cooling.
    Gas cartridges 2 are adapted to contain a coolant under elevated pressure. To this end, a gas cartridge 2 in an unused state forms a sealed volume in which the coolant can be stored. The gas cartridge 2 preferably comprises an opening which in the unused state is closed off from the gas cartridge 2 via a closure, which closure serves to keep the coolant within the gas cartridge 2 in an unused condition. A coolant consists of one or more chemical agents. A coolant suitable for use in the present invention can provide temperatures that are sufficiently low for wart treatment. Dimethyfether, n-butane, isobutene, propane, nitrogen, N suitable for the present invention. Those of ordinary skill in the art can understand that a refrigerant may consist of various chemical agents to thereby lower the internal pressure of the gas cartridge 2 necessary to reach a desired boiling point. Those of ordinary skill in the art can also understand that due to the increased pressure present in the container, a coolant may be present in the form of a liquid or a gas / liquid mixture. For refrigerant in the form of a liquid, the term "liquid refrigerant" is used in this text. For refrigerant in gas form the term "gaseous refrigerant" is used in this text. Various materials, such as, for example, steel and aluminum, are suitable as material for the container.
    Various materials, such as for example steel, rubber, plastic and / or a synthetic material are suitable as material for sealing the gas cartridge 2. The average person skilled in the art can understand that the type of material for the gas cartridge: 2 and the closure of the gas cartridge 2 has been chosen can be based on the corrosion resistance due to contact with the refrigerant, and the ability to withstand the high internal pressure levels and the low temperatures when containing a refrigerant, such as, for example, liquid nitrous oxide under elevated pressure. In the wart pen according to the present invention, the gas cartridge 2 is at least partially accommodated in a cartridge housing 1 adapted for this purpose.
    The dosing device of the wart pen according to the present invention is adapted to receive coolant from the gas cartridge 2 and to dose this coolant to the applicator 7 of the dosing device. The dosing device comprises a coolant passage and is provided with one or more housings 3, 4, 6, 10. The coolant passage forms a passage through the dosing device, through which coolant can flow from the gas cartridge 2 through the dosing device to the applicator 7 when the coolant from the gas cartridge 2 is made available for the dosing device. The one or more housings 3, 4, 6, 10 of the dosing device are adapted to comprise other parts of the dosing device and to comprise a coolant. The dosing device comprises a distal side and a proximal side. The dosing device is suitable for being attached to the cartridge housing 1 via the distal side.
    The proximal side of the dosing device is equipped with an applicator 7 for applying low temperatures to one or more warts to be treated. The applicator 7 preferably has a porous structure and preferably consists of a material with a high thermal conductivity and is configured to disperse liquid coolant while the liquid coolant extracts heat from the liquid coolant evaporator applicator 7. Sintered metals, such as, for example, sintered copper, aluminum or steel, can be used as material for the applicator 7. In addition, the applicator 7 can also consist entirely or partially of a porous plastic, such as, for example, porous polyethylene. The applicator 7 comprises an application surface along which low temperatures can be applied to one or more warts to be treated. Preferably, the application surface of the applicator 7 corresponds to the side of the applicator 7 that is most distant from the wart pen. Preferably, the portion of the applicator that is not shielded from the environment at the level of the application surface is shielded. Distinctly relative to the applicator 7, the dosing device embraces a perforator 5 which is adapted to puncture the gas cartridge 2. The puncture of the closure of the gas cartridge 2 by the perforator 5 is preferably used for making coolant available from the gas cartridge 2, for the dosing device.
    The perforator 5 preferably consists of a material with resistance up to corfSf 2 O 1 by contact with the coolant and the possibility of reflecting the high pressure levels exerted by the coolant as well as the low temperatures of the coolant. In addition, the perforator 5 preferably consists of a material that can puncture the closure. The perforator 5 consists of, for example, metal. The perforator is preferably hollow so that coolant can flow through the perforator.
    Between the applicator 7 and the perforator 5, the dosing device is provided with a valve body for closing and / or opening the coolant passage. When a coolant has been made available to the dosing device, a sealed valve body will ensure that the coolant can only flow to the valve body, while an opened valve body allows flow of the coolant through the valve body to the applicator 7. ; The closure cap 11 of the wart pen according to the present invention is adapted to be removably positioned on and attached to the proximal side of the dispenser. "Positioning and mounting of the closure cap 11 on the proximal side of the dosing device ensures complete enclosure and therefore protection of the applicator 7. Preferably, the closure cap 11 is arranged to enclose the applicator 7 in a liquid-tight manner. With the term" liquid-tight " in this text it is meant that there is a minimum leakage of 'Liquid coolant, in case this coolant is present in the applicator 7. The term "minimum leakage" in this text means that a maximum of 5% of the liquid coolant is released to the environment when the closure cap 11 is attached to the proximal side of the dosing device In a further preferred embodiment maximum 3.0%, more preferably maximum 1.0% and most preferably maximum 0.1% of the liquid coolant released to the environment when the closure cap 11 is attached to the proximal side of the dosing device Minimizing release or loss of fluid coolant at the environment, at the level of the applicator 7, ensures that the liquid coolant can be optimally used for cooling the applicator 7 by means of evaporative cooling. When coolant is present at the level of the applicator 7, the sealing cap 11 furthermore provides an insulation of the applicator 7 relative to the environment, so that evaporative cooling of the applicator 7 can be done more efficiently. For applying low temperatures via the applicator 7 to one or more warts to be treated, it is desirable that the closure cap 11 is not positioned and / or attached to the proximal side of the dosing device. The closure cap 11 is preferably made of polymers and preferably produced by injection molding in a mold. The closure cap 11 is preferably made from styrene acrylonitrile.
    At least one housing '3, 4,' 6, 1Ό of the dosing device and / or the cartridge housing 1 of the wart pen according to the present invention is made from a glass fiber reinforced plastic. A plastic reinforced with glass fibers is a strong material with a light weight that is cheaper than high-quality lightweight materials such as aluminum and carbon fiber. This makes a plastic reinforced with glass fibers extremely suitable as material for the cartridge housing 1 and / or at least one housing 3, 4, 6, 10 of the dosing device, since these housings are intended for safety measures and for efficient use of the wart pen, the high pressure levels caused by the coolant under elevated pressure must withstand. A suitable example of a plastic reinforced with glass fibers is polyoxymethylene reinforced with glass fibers.
    According to an embodiment of the first aspect of the invention, the cartridge housing 1 and / or at least one housing 3, 4, 6, 10 of the dosing device have a maximum compression force of 1850 IM to 6400 N, measured according to ASTM D695-10. Such values of maximum compression force for wart pen housings are important in resisting the high pressure levels exerted by a coolant under elevated pressure present in the wart pen.
    According to an embodiment of the first aspect of the invention, the applicator 7 has a volume of 0.05 cm 3 to 1.00 cm 3. Preferably, the applicator 7 has a volume of 0.150 cm 3 to 0.500 cm 3. The applicator 7 can occur in various geometries. Thus, the applicator 7 can, for example, take the form of a beam, cube or cylinder. The applicator 7 is preferably in the form of a cylinder. The stated volumes and geometries are suitable for obtaining an applicator 7 with an application surface that is desirably dimensioned for treating one or more warts. In addition, the stated volumes are large enough to cause a sufficient amount of evaporative cooling to occur in the applicator 7 by means of a coolant.
    According to an embodiment of the first aspect of the invention, the dosing device comprises a device for controlling the flow of the coolant. This indicates flow control of the coolant which can flow through the valve body through the valve body to the applicator 7 in the open state. Through flow control, the flow rate of the coolant can be adjusted so that ff1l2 coolant can flow to the applicator 7 in a sufficient amount and with a sufficient speed, so that a desirable amount of evaporative cooling can occur in the applicator 7. “Without flow control, the flow rate of the coolant would be too large to use the wart pen effectively for its intended purpose. In the prior art, a porous filter is usually used for flow rate control of coolant in wart pens. Such a porous filter could also be used for flow control in the wart pen of the present invention. However, the present invention proposes a flow control device that makes an additional flow control component, such as, for example, a porous filter, superfluous, which is a way to reduce the cost of a wart pen. As mentioned above, a coolant passage runs through the dosing device through which coolant can flow from the gas cartridge 2 through the dosing device to the applicator 7. According to a preferred embodiment, the coolant passage is locally severely narrowed in the portion adjacent and proximal to the body member. This narrowing will ensure flow control of the coolant. After this local constriction, the coolant passage towards the applicator 7 will broaden again.
    According to an embodiment of the first aspect of the invention, the closure cap 11 consists of a first closure cap housing provided with an open proximal end and a closed distal end, and a second closure cap housing provided with a closed proximal end and a open distal end, which is at least partially accommodated by the first closure cap housing, and which, when the closure cap 11 is mounted on the proximal side of the dosing device, completely encloses the applicator 7 and whose open distal end is provided with a connecting mechanism to to engage on the proximal side of the dosing device. Ambient air can move between the closed proximal end of the second closure cap housing and the first closure cap housing. The present air layer provides an insulation of the first sealing cap housing relative to the second sealing cap housing. This is important when the applicator 7 is cooled by evaporative cooling and the sealing cap 11 is mounted on the proximal side of the dosing device for protection and liquid-tight enclosing of the applicator 7. The second sealing cap housing can hereby be cooled considerably. The insulation of the first sealing cap housing by the air layer ensures that the sealing cap 11 can be securely grasped at the height of this first sealing cap housing by a user of the wart pen, without an adverse effect of the low temperatures at the level of the second end cap housing. A second aspect of the invention relates to a method for operating a wart pen, the method comprising the steps of: providing a wart pen for treating warts, the wart pen comprising: a cartridge housing 1 in which a gas cartridge 2 is at least partially accommodated, which gas cartridge 2 comprises a coolant under elevated pressure; a dosing device with a coolant passage, which dosing device is suitable for being attached to the cartridge housing 1 by means of a distal side, which dosing device is provided on a proximal side with an applicator 7 provided with an application surface for administering low temperatures to one or more treat warts, which dosing device comprises a perforator 5 distal to the applicator 7, which perforator 5 is adapted to puncture the gas cartridge 2, and which dosing device is provided between the applicator 7 and the perforator 5 with a valve body for closing and / or opening of the refrigerant passage; · A closure cap 11 adapted to be removably positioned on and attached to the proximal side of the dosing device; - operating the valve body; - applying the applicator 7 to one or more warts; wherein to operate the valve body, the closure cap 11 is attached to the proximal side of the dispensing device, and the closure cap 11 is removed after operating the valve body.
    For possible embodiments of a wart pen that can be used in the method according to the second aspect of the present invention, reference is made to the description of the wart pen according to the first aspect of the present invention.
    In a step of the method, a wart pen is provided in which coolant from the gas cartridge 2 is available for the dosing device. A further step of the method involves operating the valve body. In the unused state of the wart pen, the valve body is preferably closed. During operation of the valve body, the valve body is opened so that coolant can flow to the applicator 7, which applicator is subsequently cooled. After operating the valve body for a certain time, the applicator 7 is applied to one or more warts for its treatment. In the method, for closing the valve body, the closing cap 11 is attached to the proximal side of the dosing device, and after operating the valve body, the closing cap 11 is removed. This means that during operation of the valve body, the closure cap 11 is positioned on and attached to the proximal side of the dispenser. The attachment of the closure cap 11 on the proximal side of the dosing device shields the applicator 7 from the environment. This shielding of the applicator 7 includes both the liquid-tight enclosure of the applicator 7 and the isolation of the applicator 7 from the environment. As a result, during operation of the valve body, the applicator 7 can be cooled faster by evaporative cooling of the coolant at the level of the applicator 7 than if the closing cap 11 were not attached to the proximal side of the dosing device. This faster and consequently more efficient cooling of the applicator 7 provides a saving of coolant, which is economically favorable for a user of the wart pen.
    According to an embodiment of the second aspect of the invention, the method further comprises the step of puncturing the gas cartridge 2 through the perforator 5. The addition of this step in the method allows a user to open an opening just before operating the wart pen in the gas cartridge 2 so that the coolant from the gas cartridge 2 is made available to the dosing device. This has the advantage that the gas cartridge 2 can remain closed until the first operation of the wart pen, which prevents any loss of coolant before the wart pen is put into use.
    According to an embodiment of the second aspect of the invention, a puncture of 750 N is exerted by puncturing the gas cartridge 2 by means of the perforator 5. For puncturing the gas cartridge 2 by means of the perforator 5, a force of at most 600 N, and more preferably a force of at most 450 N, is preferably exerted. The puncturing of the gas cartridge 2 by means of the perforator 5 by means of forces corresponding to the above-mentioned force values contributes to a safe discharge of coolant when puncturing the gas cartridge 2, without causing significant damage to a perforator 5, cartridge housing 1 or dosing device of reasonable strength. The perforator 5, cartridge housing 1 and dosing device are preferably designed in such a way and are preferably made of sufficiently strong materials so that they can withstand the above-mentioned force values. The perforator, for example, made of metal. The cartridge housing 1 and dosing device are for instance made of a plastic. Preferably, the cartridge housing 1 'and / or at least a portion of the metering device is made of a plastic reinforced with glass fibers or a plastic reinforced with analog suitable components for reinforcement.
    According to an embodiment of the second aspect of the invention, the application surface of the applicator 7 reaches a temperature lower than the temperature of the coolant by operating the valve body. The application surface of the applicator 7 is the surface of the applicator 7 along which low temperatures can be applied to one or more warts to be treated. The temperature that is lower than the temperature of the coolant is achieved by evaporative cooling, namely because heat is withdrawn from the liquid coolant applicator 7. The applicator 7 preferably has a porous structure and preferably consists of a material with a high thermal conductivity and is configured to disperse liquid coolant. The porous structure comprises pores. Through the applicator 7 a central axis towards the application surface can be taken into consideration. Over the volume of the applicator 7, the average pore size per surface can vary across this central axis. Preferably, the average pore size per surface area decreases transversely to this central axis towards the application surface. This provides less space for discharging the gas produced by evaporative cooling at the level of the application surface, which results in an increased cooling on site. Sufficient insulation of the applicator 7 from the environment can contribute to achieving a temperature of the application surface of the applicator 7 that is lower than the temperature of the coolant by evaporative cooling of the applicator 7.
    According to an embodiment of the second aspect of the invention, nitrous oxide or INhO is used as the coolant. N2O has a boiling point of -89 ° C and will be able to extract a lot of heat from the applicator 7 by evaporation, so that it can be cooled sufficiently for wart treatment, preferably a temperature lower than -60 ° C, more preferably a temperature lower than - 70 ° C and most preferably a temperature lower than -75 ° C.
    According to an embodiment of the second aspect of the invention, the application surface of the applicator 7 reaches a temperature of -80 ° C to -95 ° C by operating the valve body when N2O is used as a coolant. The specific temperature reached depends inter alia on the structure of the applicator 7 and the degree of shielding of the applicator 7 through the closure cap 11 during the operation of the valve body. The above temperatures are suitable as initial temperatures for the treatment of warts.
    According to an embodiment of the second aspect of the invention, the valve body is operated for a duration of 0.2 seconds to 5.0 seconds. Since in the method during operation of the valve body the applicator 7 is shielded from the environment by the closure cap 11, the application surface of the applicator 7 can be cooled by means of N2O to a temperature of -80 ° C to -95 ° C by operate the valve body for such a short period of time.
    A third aspect of the invention relates to a use of a method according to the present invention for operating a wart pen according to the present invention.
    In the following, the invention is described on the basis of non-limiting examples illustrating the invention, which are not intended or may be interpreted to limit the scope of the invention. EXAMPLES EXAMPLE 1:
    Figures 1 to 8 illustrate a possible embodiment of a wart pen according to the present invention. According to this possible embodiment, the applicator 7 is supported by housing 6, the perforator 5 is enclosed by a housing 4 and the valve body occurs in the form of a ball 8 resiliently supported by a spring 9. According to this possible embodiment, the dosing device further comprises two housings 3, 10 for accommodating components of the dosing device. O-rings 12, 13, 14 are provided to prevent refrigerant losses.
    Figure 2 shows the wart pen in which coolant can flow from the gas cartridge 2 through the dosing device to the valve body. In Figure 2, after all, the valve body is closed and the coolant can flow up to the ball 8 of the valve body. The opening of the gas cartridge 2 along which coolant can flow towards the dosing device is preferably caused by puncturing the gas cartridge through the perforator 5. Figure 3 shows the wart pen in which the valve body is operated. This operation of the valve body is achieved by. exerting an external pressure on the wart pin, this external pressure being directed against the internal pressure caused by the coolant in the wart pin, and being directed against the force of the spring 9. By operating the valve body, the coolant will be able to flows to the applicator 7.
    Flow control of the coolant from the valve body to the applicator 7 is obtained by guiding the coolant along a restriction 15 present in the housing 6 of the applicator 7. As shown in Figure 4, the side of the relevant housing 6 is adjacent to the ball 8 concave in shape. The narrowing 15 for as a notch in this concave shape adjacent to the ball 8. The restriction 15 is connected to the part of the coolant passage that is bounded by the housing 6 of the applicator.
    In the possible embodiment of the wart pen, the dosing device and the cartridge housing 1 can be attached to each other via a rotational movement in a specific direction of rotation, wherein the thread 16 of a housing 3 of the dosing device is turned into the thread 19 of the cartridge housing 1 and finally the protruding structure 17 of the housing 3 of the dosing device is brought to the level of the tooth cartridge 20 of the cartridge housing 1 zaP®. The tooth cartridge 20 blocks movement of the protruding structure 17 in the direction of rotation opposite to the direction of rotation of the attachment, thereby preventing rotation of the housing 3 of the dispensing device relative to the cartridge housing 1. In view of the presence and location of the perforator 5 in the dosing device, when the dosing device with cartridge housing 1 is attached, the perforator 5 will pierce a still enclosed gas cartridge 2 by means of the rotation movement, so that the coolant can be made available to the dosing device. The protection against loosening once dosing device and cartridge housing 1 are tightened is important for the safety of a user of the pen. After all, loosening is dangerous, since the coolant would end up in an uncontrolled manner under elevated pressure.
    In the possible embodiment of the wart pen, a safety feature includes preventing unintended positioning and mounting of the closure cap 11 on the proximal side of the dosing device, as well as the possibly resulting unintended operation of the wart pen valve mechanism. This safety measure relates to protrusions 22 of the closure cap 11 which must be placed in corresponding recesses 24 of a housing 10 of the dosing device before an external pressure on the closure cap 11 can lead to an operation of the valve body. The illustrated embodiment of the closure cap 11 has three protrusions 22 which can be positioned in the corresponding three recesses 24 of the illustrated embodiment of the respective housing 10. Only one of these recesses 24 is clearly visible in Figure 8. The recesses 24 of the respective housing 10 also functions as ventilation holes for evacuating gaseous coolant. The embodiment of the closure cap 11 has several ventilation holes 23. In addition, another housing 3 of the dosing device also comprises ventilation holes 18.
    In the possible embodiment of the wart pen, the cartridge housing 1 has a triangular shape whose corners are rounded. This shape of the cartridge housing 1 has the advantage that when the cartridge housing 1 or the wart pen is on a horizontal surface, it cannot start rolling over this surface when a user comes into contact with it, for example when a force is exerted on it . Compared to non-rounded corners, the rounded corners 21 of the preferred embodiment of the 8 c cartridge housing 1 or the wart pin falling on a surface is smaller. "EXAMPLE" 2:
    For a possible embodiment of a wart pen according to the present invention, it was investigated in an experiment which temperatures can be reached at the application surface of the applicator 7 by evaporative cooling of the applicator 7. The wart pen corresponds to the possible embodiment as shown in the Figures 1 to 8. In addition, the evolution of the temperature obtained as a function of time was investigated. For example, for warts, low temperatures, lower than -50 ° C, must be achieved for effective treatment of the warts. These low temperatures must also be able to be maintained for a sufficiently long time. For treatment of normal warts, a treatment time of 20 s is recommended at these low temperatures. For foot warts, after this treatment time of 20 s, an additional treatment time of 20 s, in which the temperatures remain below -25 ° C, remains desirable because of the thick horny layer of feet. A wart pen according to the present invention can achieve these time-temperature conditions at the application surface of an applicator 7, as demonstrated in the experiment for embodiments of the wart pen. During the experiment, in particular, the effect of different applicator 7 types on the temperature achieved by evaporative cooling was investigated. Three cylindrical applicator 7 types were evaluated, namely two single-layer applicators, each constructed from a hydrophobic porous material, and a double-layer applicator, consisting of a stack of the hydrophobic porous materials used for the single-layer applicators. A first single-layer applicator was constructed from a first hydrophobic porous material with an average pore size ranging from 20 to 40 µm and a porosity greater than 40%. A second single-layer applicator was constructed from a second hydrophobic porous material with an average pore size ranging from 80 to 120 µm and a porosity greater than 35%. The third applicator was a double-layer applicator consisting of a stack of the hydrophobic porous materials used for the single-layer applicators.
    In the double-layer applicator, the first hydrophobic porous material was located at the level of the application surface while the second hydrophobic porous material was located further from the application surface. In the double-layer applicator, the first hydrophobic porous material contributed about 5% to 60% to full volume of the double-layer applicator. Each cylindrical applicator had the following dimensions: a full length of 10.00 ± 0.35 mm, along the central longitudinal axis through the applicator, the upper and upper; widest part, with a diameter of 6.40 ± 0.15 mm, a length of 5.00 ± 0.25 mm. The lower and at the same time least wide part had a diameter of 5.80 ± 0.15 mm. The application surface was located at the least wide part. The upper surface of the free end of the least wide portion corresponding to the administration surface was convex in shape. This convex shape was characterized by a radius of 5.50 mm, measured from the center of the plane connecting the upper with the lower part.
    In the experiment, liquid N 2 O was used under elevated pressure as a coolant under elevated pressure. This coolant was present in a gas cartridge 2 with an opening, the opening of which was initially closed by means of a closure. In a first step, the coolant was discharged by puncturing the closure by means of a perforator 5 of the wart pen. After the discharge of the coolant, the coolant could flow to the valve body of the wart pen. Subsequently, an external pressure was applied to the wart pin for operating the valve body for a period of time of about 1 s, which external pressure was applied in the opposite direction to a pressure exerted by the coolant. More specifically, the external pressure was applied to a removable closure cap 11 mounted on the proximal side of the dosing device. During the application of the external pressure, the coolant could flow past the valve body to an applicator 7, whereby the applicator 7 was cooled by means of. evaporative cooling. Cooling of the applicator 7 according to the above steps was considered a "dose" in the experiment. Immediately after exerting the external pressure, the removable closure cap 11 was removed from the wart pen and the application surface of the applicator 7 was immediately placed on a thermometer to directly determine the temperature of the application surface.
    In the experiment, 10 doses were followed for each applicator type. Figures 9-11 represent 10 doses (named "Dol", "Do2", "Do3", "Do4", "Do5", "D06", "Do7", "D08", "Do9" and "DolO, respectively) ") for each applicator type detailed data of the temperature (T) as a function of time (t) (0 to 40 s, with an interval of 5 s). Figure 9 shows the data for the first single-layer applicator. Figure 10 shows the data for the second single layer applicator. Figure 11 shows the data for the double layer applicator.
    Differences in temperature change with respect to time were observed for the single-layer applicators compared to the double-layer applicator. For the single layer applicators, two approximately linear segments could be observed, one from 5 to 15 s and one from 15 to 40 s. The temperature increase rapidly increased from 5 to 15 s. From 15 to 40 s, the temperature increase was clearly slower. The double-layer applicator exhibited a different temperature curve compared to the single-layer applicators, starting with a lag phase (5 to 15 s) followed by an approximately linear temperature increase as a function of time. During the lag phase, the average temperature remained below -71 ° C, after which an approximately linear increase in temperature was observed between 15 s and 40 s. It can be observed that from 15 s the measured temperatures are significantly lower for the double-layer applicator compared to the single-layer applicators. The double-layer applicator can therefore keep the cold obtained by evaporative cooling longer than the single-layer materials and is therefore extremely suitable for the treatment of warts by means of low temperatures.
    权利要求:
    Claims (13)
    [1]
    CONCLUSIONS
    A wart pen for the treatment of warts, comprising: - a porous housing (1) in which a gas cartridge (2) is at least partially accommodated, which gas cartridge (2) comprises a coolant under elevated pressure; - a dosing device with a coolant passage and provided with one or more housings (3, 4, 6, 10), which dosing device is suitable for being attached to the cartridge housing (1) by means of a distal side, which dosing device is equipped on a proximal side with an applicator (7) for administering low temperatures to one or more warts to be treated, which dosing device comprises, relative to the applicator (7), a perforator (5) adapted to puncture the gas cartridge (2), and which dosing device is provided between the applicator (7) and the perforator (5) with a valve body for closing and / or opening the coolant passage; - a closure cap (11) adapted to be removably positioned on and attached to the proximal side of the dosing device; characterized in that the cartridge housing (1) and / or at least one housing (3, 4, 6, 10) of the dosing device are made from a polyoxymethylene reinforced with glass fibers.
    [2]
    Wart pen according to claim 1, characterized in that the cartridge housing (1) and / or at least one housing (3, 4, 6, 10) of the dosing device have a maximum compression force of 1850 N to 6400 N, measured according to ASTM D695-10.
    [3]
    Wart pen according to claim 1 or 2, characterized in that the applicator (7) has a volume of 0.05 cm 3 to 1.00 cm 3.
    [4]
    Wart pen according to one of claims 1 to 3, characterized in that the dosing device comprises a device for controlling the flow of the coolant.
    [5]
    Wart pen according to one of claims 1 to 4, characterized in that the closure cap (11) consists of a first closure cap housing provided with an open proximal end and a closed distal end, and a second closure cap housing provided with a closed proximal end and an open distal end which is accommodated at least partially by the first closure cap housing and which, when the closure cap (11) is arranged on the proximal2 'side of the dosing device, completely encloses the applicator (7) and of which the open distal end is provided with a sultaristic mechanism to engage the proximal side of the dosing device.
    [6]
    A method of operating a wart pen according to at least one of claims 1 to 5, the method comprising the steps of: - providing a wart pen for treating warts, the wart pen comprising: a cartridge housing (1) wherein a gas cartridge (2) is at least partially accommodated, which gas cartridge (2) comprises a coolant under increased pressure; a dosing device with a coolant passage, which dosing device is suitable for being attached to the cartridge housing (1) by means of a distal side, which dosing device is provided on a proximal side with an applicator (7) provided with an application surface for applying low temperatures to one or more warts to be treated, which metering device differs relative to the applicator (7), a perforator (5) adapted to puncture the gas cartridge (2), and which metering device between the applicator (7) and the perforator (5) ) is provided with a valve body for closing and / or opening the coolant passage; - a closure cap (11) adapted to be removably positioned on and attached to the proximal side of the dosing device; - operating the valve body; - applying the applicator (7) to one or more warts; characterized in that to operate the valve body, the closure cap (11) is attached to the proximal side of the dispensing device, and in that the closure cap (11) is removed after operating the valve body.
    [7]
    Method according to claim 6, characterized in that the method further comprises the step of puncturing the gas cartridge (2) through the perforator (5).
    [8]
    Method according to claim 7, characterized in that a force of at most 750 N is exerted by means of the perforator (5) for piercing the gas cartridge (2).
    [9]
    Method according to one of claims 6 to 8, characterized in that, by operating the valve body, the application surface of the applicator (7) reaches a temperature that is lower than the temperature of the coolant.
    [10]
    Method according to one of claims 6 to 9, characterized in that nitrous oxide is used as the coolant.
    [11]
    Method according to claim 10, characterized in that the application surface of the applicator (7) reaches a temperature of -80 ° C to -95 ° C by operating the valve body.
    [12]
    A method according to claim 11, characterized in that the valve body is operated for a period of time from 0.2 s to 5.0 s.
    [13]
    Use of a method according to any of claims 6 to 12 for operating a wart pen according to any of claims 1 to 5.
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