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    • 专利摘要:
    composition attirant les acari avec un objet contenant des acari. Les acari entrent dans le feuillet qui peut alors être retirée pour éliminer les acari. L'invention concerne en outre des compositions attirant les acari et des produits et des kits pour attirer, piéger et éliminer les acari. The present invention relates to compositions and methods for removing acari, such as dust mites. The methods include contacting a sheet impregnated with a composition attracting acari with an object containing acari. The acari enter the leaflet which can then be removed to eliminate the acari. The invention further provides acari-attracting compositions and products and kits for attracting, trapping and eliminating acari.
    公开号:BE1022723B1
    申请号:E2016/0024
    申请日:2016-02-02
    公开日:2016-08-23
    发明作者:Anne-Catherine Mailleux
    申请人:Domobios Sa；
    IPC主号:
    专利说明:

    METHOD AND DEVICE FOR TRAPPING ACARI DOMAIN OF THE INVENTION
    The present invention relates to a method and a device for trapping acari, such as dust mites. The invention particularly relates to compositions for attracting acari, as well as their uses and applications.
    BACKGROUND OF THE INVENTION
    Acari are a taxon of arachnids that contain dust mites and ticks. In particular, dust mites are widespread in homes around the world. They reproduce very prolifically and can produce large quantities of allergens contained in their excrement. Therefore, dust mites are responsible for allergic symptoms in humans (for a review on dust mites, see Colloff, 2009), such as itching and watery eyes, atopic dermatitis (eczema ), asthma, allergic rhinitis, permanent congestion of the nose or ears. Allergies due to dust mites can turn into fatal symptoms. House dust mites are more commonly responsible for health problems in vertebrates, as they are likely to cause allergies in birds (eg chickens, ducks or geese), as well as in mammals, such as as pets (eg, dogs and cats), horses, goats or cows. Dust mites are particularly responsible for atopic dermatitis in pets, and more specifically in dogs and cats.
    Two species are mainly responsible for a large number of allergies: the European domestic mite (Dermatophagoides pteronyssinus) and the American domestic mite (Dermatophagoides farinae). These two species are different but they are not confined specifically to Europe or North America; we meet them all over the world.
    Mites thrive in the environment provided by beds, blankets, comforters, pillows, mattresses, carpets, armchairs, cushions, upholstered furniture used by humans, as well as in places such as soft toys, cushions and blankets for dogs, cats and other domestic animals, dog and cat baskets, baskets of other pets, dog and cat kennels, and houses in general.
    A problem associated with areas where live mites are found is the reduction of allergic reactions, in other words the way to prevent or treat allergic reactions, which users, both humans and pets, may suffer when they are contact with these contaminated areas, or when they are close to them.
    Various disinfection methods are available to remove and / or kill acari, such as dust mites. The simplest and most common way to remove acari is to suck. This process only allows to remove the acari, but does not kill them all and depends to a certain degree on the equipment used, based in particular on the collection bags, which prevent the spread of acari, and allergens derived from the most important acari . In addition, all surfaces containing acari are not likely to be treated in this way.
    Another way to manage acari infestations is to apply pesticides. While this process effectively kills acari, and therefore prevents its diffusion, the use of inherently toxic pesticides in a domestic environment is not often perceived as acceptable. However, these methods simply kill some of the acari but do not suppress them, nor do they remove their allergens. In addition, similar to vacuum cleaning, not all surfaces can be treated in this way.
    A common disadvantage of all conventional acari disinfection processes to date is the accessibility of mites combined with safety and efficacy. Indeed, the mattresses are generally of considerable thickness, so that the suction or the application of pesticides may result only in a superficial treatment. Since mites can be at the heart of the mattress, often such a superficial treatment is not very effective. In recent years, mite attractants have been associated with pesticides to at least partially meet accessibility requirements (JP2000336007). Given the above, there is a need to improve disinfection and to provide other effective methods for the control of acari, such as dust mites. In particular, there is a need for processes and products that should be safe for human health, cost-effective and easily applicable while respecting the environment. SUMMARY The invention relates to a composition for attracting acari, comprising an attractant in which the attractant is lavandulol in a concentration of 0.0000001% (v / v) to 10% (v / v). The invention further relates to a composition comprising at least one additional attractant, wherein said additional attractant is a polysorbate in a concentration of 0.0000001% (v / v) to 10% (v / v).
    In a particular embodiment, the composition of the invention further comprises at least one solvent, at least one stabilizing agent, at least one emulsifier, at least one excipient and / or at least one perfume. In a particular embodiment, the perfume (s) intended to be used in the composition of the invention comprise an essential oil of Mentha citrata, Mentha piperita, Mentha arvensis, Eucalyptol radiata, Vanillaplanifolia, Vanilla odorata or combinations thereof .
    The present invention further relates to a method for attracting and retaining acari, comprising the steps of: a) providing a sheet having sufficiently large interstices and a thickness large enough to retain the acari; and b) application on said sheet of an attractive and non-fatal dose of the composition according to the invention.
    In a particular embodiment, the method of the invention further comprises the steps of contacting said sheet before step a) or after step b) with an object suspected of containing acari.
    In a particular embodiment, the method of the invention comprises contacting said sheet with an object suspected of containing acari for at most about 3 hours, preferably for at most about 2 hours, preferably at most about 2 hours, preferably for at most about 1 hour, preferably for at most about half an hour, after step b).
    The present invention further relates to a method for removing acari, comprising the steps of: i) performing the method for attracting and retaining acari according to the invention; and ii) removing said sheet from said object suspected of containing acari.
    The present invention further relates to a sheet having sufficiently large interstices and a thickness sufficiently large to retain acari, comprising a non-lethal attractive dose of the composition according to the invention.
    In a particular embodiment, the sheet according to the invention or intended to be used in the invention comprises from 0 to 100% of polyester. In another embodiment, the sheet according to the invention or intended to be used in the invention comprises at least 30%, preferably at least 50%, preferably at least 70%, preferably at least 80%, of preferably at least 90%, preferably at least 95% wool and / or cotton and more preferably 100% wool or cotton. In another particular embodiment, the sheet according to the invention comprises at least 30% to 100% wool and / or cotton and 0% to 70% viscose and / or polyester.
    The present invention further relates to a kit for attracting acari comprising a composition according to the invention and a sheet having sufficiently large interstices and a sufficiently large thickness to retain the acari.
    The present invention further relates to a unit dose applicator comprising a composition according to the invention, designed to release a non-lethal attractive dose of said composition per unit dose per unit area.
    In a particular embodiment, said acari referred to with the composition, the method, the sheet, the kit or the unit dose applicator according to the invention, are selected from the group consisting of Dermatophagoides pteronyssinus and Dermatophagoides farinae.
    In a particular embodiment, said non-lethal attractive dose per unit area for use in the method, sheet or unit dose applicator according to the invention is in the range of 5 mL / m2 to 2 000 mL / m2, preferably 10 mL / m2 to 1000 mL / m2.
    The present invention further relates to the use of lavandulol and / or at least one polysorbate for attracting acari.
    The present invention further relates to the use of a composition according to the invention for attracting acari.
    DEFINITIONS
    In the present invention, the following terms have the following meanings: The singular forms "a", "a", "the" and "the" as used herein include singular and plural referents unless otherwise specified. - The terms "comprising", "includes" and "consisting of" as used in this document are synonymous with "including", "includes" or "containing", "contains", and are inclusive or open and do not exclude any additional element, process or step, not described. It will be appreciated that the terms "comprising", "includes" and "consisting of" as used herein include the terms "consisting of", "consists" and "consisting of", and the terms "consisting of". substantially "," consists substantially "and" substantially consists of ". The description of the digital ranges by their ends includes all the numbers and all the fractions included within the different ranges, as well as the ends described. - The term "approximately" or "approximately" as used in this document when referring to a measurable value such as a parameter, quantity, time duration, and the like, is intended to include variations of ± 20% or less, preferably ± 10% or less, more preferably ± 5% or less, and still more preferably ± 1% or less of the specified value, in the to the extent that these variations are suitable for carrying out the disclosed invention. It should be understood that the value to which the "about" or "approximately" modifier refers is itself also specifically, and preferably, described. - whereas the terms "one or more" or "at least one", for example one or more or at least one element (s) of a group of elements, are clear in themselves, by means of additional examples, the term includes inter alia a reference to any of said elements, or any two or more of said elements, such as, for example,> 3,> 4,> 5,> 6 or> 7 etc. any of said elements, and up to all of said elements.
    All references cited in this specification are incorporated by reference in their entirety. In particular, the teachings of all specifically mentioned references are incorporated by reference.
    Unless defined otherwise, all terms used to describe the invention, including technical and scientific terms, have the meanings commonly understood by those skilled in the art to which the invention belongs. As additional guidance, definitions of terms are included to better appreciate the teachings of the present invention.
    Different aspects of the invention will be further defined in the following passages. Each aspect so defined may be combined with any other aspect or other aspect unless expressly stated otherwise. In particular, any element indicated as being particular, preferred or advantageous may be combined with any other element or any other element indicated as being particular, preferred or advantageous.
    The references throughout this description to "an embodiment" (1) or "an embodiment" (any) mean that a particular element, a particular structure or a particular characteristic described with respect to the mode of embodiment is included in at least one embodiment of the present invention. Thus, the occurrences of the phrases "in one embodiment" (1) or "in one embodiment" (any) in different places in this description do not necessarily refer to the same embodiment, but can. In addition, particular elements, particular structures or particular features may be combined in any suitable manner, as will be apparent to those skilled in the art from this description, in one or more embodiments. Further, while some embodiments described herein include some, but not others, elements included in other embodiments, the combinations of the elements of different embodiments are intended to be included in the scope. of the invention, and form different embodiments, as those skilled in the art will understand it. For example, in the appended claims, any of the claimed embodiments may be used in any combination.
    In the following detailed description of the invention, reference is made to the accompanying drawings which form a part thereof, and on which are presented by way of illustration only the specific embodiments in which the invention can be implemented. convenient. It should be understood that other embodiments can be used and that structural or logical modifications can be made without departing from the scope of the present invention. The following detailed description is, therefore, not to be understood in a restrictive sense, and the scope of the present invention is defined by the appended claims.
    DETAILED DESCRIPTION The invention thus relates to a composition intended to attract acari, comprising lavandulol.
    As used herein, the term "lavandulol" refers to the 5-methyl-2-prop-1-en-2-ylhex-4-en-1-ol monopertic alcohol, also known as 2-isopropenyl-5-methyl-4-hexen-1-ol, having the molecular formula CioHisO (CAS Registry Number: 498-16-8). Lavandulol can be found in a variety of essential oils, such as lavender oil, in which it is present in an amount of about 0.78%. Lavandulol is a chiral molecule whose enantiomer (R) has a significant aroma, while the (S) enantiomer has only a weak odor. In the meaning of the present invention, "lavandulol" means that the composition of the invention may comprise the enantiomer (R) of lavandulol or the enantiomer (S) of lavandulol alone, or any mixture of these enantiomers, as for example compositions containing a ratio of 1/5, 1/3, 1/2, 1/1, 2/1, 3/1 or 5/1 of the enantiomer (R) of lavandulol on the enantiomer ( S) lavandulol, respectively.
    In a particular embodiment of the invention, lavandulol is obtained from a plant selected from the group of Asparagales, Asterales, Dipsacales, Ericales and Lamiales. The Asparagales preferably include Orchidaceae, preferably Acacallis superba, Aerangis appendiculata, Aerangis biloba, Aerangis brachycarpa, Aerangis confused, Aerangis distincta, Aerangis fastuosa, Aerangis kirkii, Aerangis kotschyana, Aerangis somalensis, Aeranthes grandiflora, Aerides crassifolia, Aerides fieldingii, Aerides Lawrenceae, Ancistrochilus rothschildianus, Angraecopsis amaniensis, Angraecum aporoides, Angraecum bosseri, Angraecum eburneum,
    Angraecum eichlerianum, Angraecum girymae, Angraecum sesquipedale, Anguloa 'clowesii, Bollea coelestis, Brassavola digbyana, Brassavola glauca, Brassavola nodosa, Brassavola tuberculata, Brassia lobbii, Brassia verucosa, Catasetum viridiflavum, Cattleya araguaiensis, Cattleya bicolor, Cattleya dowiana, Cattleya labiata, Cattleya Cattleya leopoldii, Cattleya luteola, Cattleya maxima, Cattleya percivaliana, Cattleya porphyroglossa, Cattleya schilleriana, Caularthron bicornutum, Chondrorhyncha lendyana, Cirrhaea dependens, Cirrhopetalum fascinor,
    Cirrhopetalum robustum, Cochleanthes aromatica, Cochleanthes discolor,
    Cochleanthes marginata Coelogyne zurowetzii Constantia cipoensis, Coryanthes leucocorys, Coryanthes mastersiana, Coryanthes picturata, Coryanthes vieirae, Cymbidium goeringii, Dendrobium anosmum, Dendrobium antennatum, Dendrobium beckleri, Dendrobium brymerianum, Dendrobium carniferum, Dendrobium Chrysotoxum, Dendrobium delacourii, Dendrobium lichenastrum, Dendrobium moniliforme , Dendrobium monophyllum, Dendrobium pugioniforme, Dendrobium trigonopus, Dendrobium unicum, Dendrobium virgineum, Dendrobium williamsonii, Dendrochilum cobbianum, Diaphananthe pellucida, Diaphananthe pulchella, Dichaea rodriguesii, Dracula chestertonii, Dryadella edwallii, Embreea rodigasiana, Encyclia adenocarpa, Encyclia baculus, Encyclia citrina, Encyclia fragrans, Encyclia glumacea, Epidendrum ciliare, Epidendrum lacertinum, Epidendrum nocturnum, Epigeneium lyonii, Eria hyacinthoides, Gongora armeniaca, Gongora cassidea, Gymnadenia conopea, Himantoglossum hircinum, Hulletia odoratissima, Huntleya heteroc litde, Huntleya meleagris, Laelia albida, Laelia anceps, Laelia autumnalis, Laelia gouldiana, Laelia perinii, Liparis viridiflora, Lycaste aromatica, Lycastus cruenta, Lycaste locusta, Masdevallia caesia, Masdevallia estradae, Masdevallia glandulosa, Masdevallia laucheana, Masdevallia striatella, Masdevallia tridens, Maxillaria nigrescens, Maxillaria picta, Maxillaria tenuifolia, Maxillaria variabilis, Miltonia regnellii, Miltonia schroederiana, Miltonia spectabilis, Miltoniopsis phalaenopsis, Neofinetia falcata, Nigritella nigra, Odontoglossum cirrhosum, Odontoglossum constrictum, Odontoglossum pendulum, Odontoglossum pulchellum, Oncidium longipes, Oncidium omit hörhynchum, Oncidium sarcodes, Oncidium tigrinum, Peristeria elata, Pescatorea cerina, Pescatorea dayana, Pescatorea lehmannii, Phalaenopsis violacea, Platanthera bifolia, Platanthera chlorantha, Plectrelminthus caudatus, Polystachya campyloglossa, Polystachya cultriformis, Polystachya fallax, Polystachya mazumbaiensis, Rangaer is amaniensis, Rhynchostylis coelestis, Rodriguezia refracta, Stanhopea jenischiana, Stanhopea oculata, Stanhopea tigrina, Trichocentrum tigrinum, Trichoglottis philippinensis, Trixspermum arachnites, Vanda coerulescens, Vanda denisoniana, Vanda tessellata, Zygopetalum crinitum. Asterales preferably include Asteraceae, preferably Anthemis nobilis, Matricaria recutita, Santolina chamaecyparissus. Dipsacales preferably include Valerianaceae, preferably Valeriana officinalis. The Ericales preferably include Lecythidaceae, for example Corythophora amapaensis, Couratari stellata, Couroupita guianensis, Eschweilera coriacea, Eschweilera pedicellata, Grias neuberthii, Peruvian Grias, Gustavia longifolia, Gustavia serrata, Lecythis confertiflora, Lecythis persistens ssp. aurantiaca, Lecythis pisonis, as well as Polemoniaceae, preferably Phlox drummondii, Phlox paniculata, and Sapotaceae, preferably Mimusops elengi, and Theophrastaceae, preferably Clavija euerganea, Clavija repanda, Deherainia smaragdina ssp. Smaragdina, Jacquinia keyensis, Jacquinia macrocarpa, Jacquinia spruce, Theophrasta Americana. Lamiales preferably include Scrophulariaceae, preferably Buddleja davidii. Malvales preferably include Thymelaeaceae, preferably Daphne mezereum. In a particular embodiment, lavandulol may also be obtained from a mixture of the aforementioned plants, or essential oils thereof. In a particular embodiment, lavandulol may also be chemically synthesized according to methods well known to those skilled in the art.
    In a particular embodiment, the present invention further relates to a composition comprising lavandulol and at least one attractant, wherein said attractant is a polysorbate. The inventors have indeed discovered, surprisingly, that the combination of these attractants resulted in properties of attraction of acari much better.
    As used herein, the term "polysorbate" refers to PEG-ylet sorbitan derivatives esterified with fatty acids, which are well known to those skilled in the art. In a particular embodiment, the term "polysorbate" as used herein includes at least one of: - sorbitan monolaureate, of formula C58H113O26 (also known as polysorbate 20 or polyoxyethylene monolaurate) (20) sorbitan, and under the usual trade names Alkest TW20 or Tween 20, and having the CAS registry number 9005-64-5), - sorbitan monopalmitate, of formula C62H123O26 (also known as polysorbate 40 or monopalmitate of polyoxyethylene (20) sorbitan, and under the trade name Tween 40, and having the CAS number 9005-66-7), - polyethylene glycol sorbitan monostearate, of formula C64H126O26 (also known as polyoxyethylene sorbitan monostearate, polysorbate 60, polyoxyethylene (20) sorbitan monostearate or octadecano [2 - [(2, 35 ', 4i) -3,4-dihydroxy-2-tetrahydrofuranyl] -2-hydroxyethyl] ester whereas, to which the European Parliament also refers as to the food additive E345, and known under the trade name Tween 60, and having the CAS registry number 9005-67-8), - polyoxyethylene (20) sorbitan monooleate formula C64H126O26 (to which the European Parliament also refers as to the food additive E433, and known under the trade names Alkest TW80, Canarcel, Poegasorb or Tween 80, and having the CAS registry number 9005-65-6), - the fatty acid ester and sorbitan ester ethoxylate of formula C34H66O11 (also known as polyoxyethylene (4) sorbitan monostearate, and under the trade names emulsifying T-61 or Tween 61, and having the CAS number 9005 -67-8), - fatty acid ester ethoxylate and sorbitan of formula C100H194O28 (also known as polyoxyethylene (20) sorbitan tristearate and under the trademark Tween 65, and having CAS number 9005-71-4), - sorbitan tristearate, of the formula CooHmOs (also known as polyoxyethylene (20) sorbitan tristearate or [(2H, 3-S, 4H) -2- Octadecanoic acid [1,2-bis (1-oxooctadecoxy) ethyl] -4-hydroxy-3-tetrahydrofuranyl] ester and under the trade names Span 65, emulsifier S65, Lonzest STS, Emalex EG-2854-S, Sorbitantristearat, Glycomul TS KFG, and having the CAS registry number 26658-19-5), - sorbitan monooleate, of formula C24H44O6 (also known as polysorbate 80, polyoxyethylene (20) sorbitan monooleate, and under the names commercial armotanpmo-20, atloxl087, atlox8916tf, atolox8916tf, POE-O capmul, crilllO, crillll, crillet4, Alkest TW 80 or Tween 80, and having the CAS registry number 9005-65-6), - polyoxyethylene sorbitan trioleate Formula C24H44O6 (also known as polyoxyethylene sorbitol trioleate, under the names erciales emsorb6903, TO-20 glycosperse, TO-20 liposorb, TO-20 protasorb, sorbimacrogoltrioleate 300 and Tween 85, and having CAS registry number 9005-70-3).
    In a particular embodiment of the present invention, the composition for attracting acari may comprise one or more of the aforementioned polysorbates, for example at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight or all.
    In a preferred embodiment of the present invention, polysorbate monostearate (Tween 60) is used as polysorbate.
    In a particular embodiment, the composition of the invention is preferably a composition in which pure (or substantially pure) active ingredients are diluted. In a particular embodiment, the composition of the invention comprises from 0.0000001% (v / v) to 10% (v / v), preferably from 0.000001% (v / v) to 0.1% (v / v), preferably from 0.00001% (v / v) to 0.01% (v / v), preferably about 0.00005% (v / v) or about 0.0001% (v / v). v) lavandulol. In another particular embodiment, the composition of the invention comprises from 0.000000095% (v / v) to 9.5% (v / v), preferably from 0.00000095% (v / v) to 0.095% by weight. % (v / v), preferably from 0.0000095% (v / v) to 0.0095% (v / v), preferably about 0.0000095% (v / v) or about 0.00000475% (v / v). (v) lavandulol.
    In another particular embodiment, the composition of the invention further comprises 0.0000001% (v / v) to 10% (v / v), preferably 0.000001% (v / v) to 0%. , 1% (v / v), preferably from 0.00001% (v / v) to 0.01% (v / v), preferably about 0.0001% (v / v) or about 0.00005% (v / v) polysorbate.
    In a particular embodiment, the composition of the invention for use in the method of the invention further comprises at least one additional attractant, preferably selected from the group consisting of: 1,3-dimethoxybenzene, undecanal, dodecan-2-one, tridecanoic acid, tridecane, 7-methyltetradecane, pentadecane, heptadecane, nonadecanoic acid, (E, E) -4,8,12-trimethyl-1,3,7,11-tridecatetraene, (E) - 1,5-octadien-3-ol, 1-methylpiperidin-2-one, (1 R, 3 R, 5 R, 7 R) -1,3,5,7-tetramethyldecyl, (Z) -1,5-octadiene, 3-ol, (Z, Z) -1,6,9-heptadecatriene, 2,3-dihydroxybenzaldehyde, 2,6-di-t-butyl-4-methylphenol, pentacosane, heptacosane, nonacosene, 2,6-dibromophenol, 2,4,6-trichlorophenol, 2,4-dichlorophenol, 2,6-dichlorophenol, 2,6-dimethyl- (E) -2,6,8-nonatriene, 2-hydroxy-6-methylbenzaldehyde, 2-methylpropan 1-ol, 2-methylbutan-1-ol, 2,6-dimethyl-2,5-heptadien-4-one, 2-methylacetophenone, 2-methyl thyl benzaldehyde, 2-methyl benzoic acid, 2-methoxy-3-methyl-1,4-benzoquinone, 2-nitrophenol, (2R, 3R) -2,3-epoxy-3,7-dimethyl-6-octenal, 3 4-dehydro-cineole, 3-ethylbenzaldehyde, 3-ethylphenol, 3-isopropyl-6-methylbenzaldehyde, 3-methylbutan-1-ol, 3-methylbenzaldehyde, propan-1-ol, 3S8S-chrysomelidial, (4aS, 7S, 7aR) -Tetrahydro-4,7-dimethylcyclopenta [c] pyranone, (4aS, 7S, 7aS) -tetrahydro-4,7-dimethylcyclopenta [c] pyranone, dihydro-5-propylfuran-2 (3H) -one, 4-hydroxy-2-methylbenzaldehyde, (5S, 8S) -2-methyl-5- (1-formylethyl) -1-cyclopentene-1-carbaldehyde, (Z, Z) -5,9-octadecadienoic acid, hexanal 6-ethylbenzaldehyde, 6-methylsalicylic acid, heptan-2-one, heptanal, 7-hydroxy-3H-isobenzofuran-1-one, 7-methyl-5-hydroxy-1,4-naphthoquinone, octan-2- one, octanal, octan-1-ol, nonan-2-one, nonanal, acetic acid, 1-phenylethanone, adenine, 3- (4-methyl-3-pentenyl) -2 (5H) -furanone, 4- (4) 3-methyl-3-pentenyl) -2 (5H) -furanone, (E) -2- (4-methyl-3-pe) ntenyl) -butenedial, (E) -2- (2-hydroxyethylidene) -6-methyl-5-heptenal, 2- (4-methylcyclohex-3-enyl) propan-2-ol, ammonia, eicosanoic acid, attractants aromatics such as oils and fats, their esters with fatty acids, benzaldehyde, (E) -2- (4-methyl-3-pentenylidene) butanedial, (E) -2- (2-hydroxyethyl) -6- methyl-2,5-heptadienal, 1R- (1R, 4E, 9S) -4,11,1-trimethyl-8-methylenebicyclo [7.2.0] undec-4-ene, (E, E) -7,11 , 15-trimethyl-3-methylene-1,6,10,14-hexadecatetraene, butyric acid and butyric alcohols, C4-12 aliphatic ketones, C4-14 aliphatic lactones, C7-10 linear aliphatic aldehydes, decanoic acid, octanoic acid, cholest-5-en-3-beta-ol, (4R, 6R, 8R) -4,6,8-trimethyldecan-2-one, (Z) -3,7, 1-trimethyl-1-1 , 6,10-dodecatrien-3-ol, (Z, E) -3,7-dimethyl-2,6-octadienal, carbon dioxide, (24S) -24-methylcholesta-5,22 (E) -dienst 3-Beta-ol, N, N-diethyl-3-methylbenzamide, 1-tridecene, 1-pentadecene, 1-heptad cetene, 1-nonadecene, 1-eicosenal, 1-octen-3-ol, 4-heptadecene, 6,9-heptadecadiene, 8-heptadecene, 8-nonen-2-one, 9,17-octadecadienal, N, N- diethyl-2,5-dimethylbenzamide, (E, E, E) -3,7,11,15-tetramethylhexadeca-1,3,6,10,14-pentaene, (E, E) -3,7,1 l 2,6,10-trimethyl-dodecatrienal, (E) -4,8-dimethyl-1,3,7-nonatriene, (E) -9-octadecenoic acid, (3S, 8R) -2-methyl-5- (1-formylethyl) -1-cyclopentene-1-carbaldehyde, ester-based food flavoring additives such as geranyl, esters of aromatic attractants such as oils and fats, ethanol, ethyl hexadecanoate, ethyl- Z2E4-decadienoate, formic acid, 3-hydroxybenzene-1,2-dicarbaldehyde, dihydro-5-methylfuran-2 (3H) -one, (E) -3,7-dimethyl-2,6-octadienal, (E) - 3,7-Dimethyl-2,6-octadien-1-ol, (E) -3,7-dimethyl-2,6-octadienyl formate, (E, E) -3,7,11,15-tetramethyl- 1,6,10,14-hexadecatetene-3-ol, guanine, heptadecadiene, (Z, Z) -hexyl-9,12-octadecadienoate, 2-form Hexyl yl-3-hydroxybenzoate, hexyl stearate, hypoxanthine, isobutyric acid, (S) -3-methyl-6-isopropenyl-2-cyclohexen-1-one, 4S-4-isopropenyl-3-oxo-1 cyclohexene-1-carboxyaldehyde, 1,3,5,7-tetramethyldecyl formate, dodecanoic acid, limonene, 2,6-dimethyl-2,7-octadien-6-ol, (Z, Z) -9,12 acid -octadecadienoic acid, (Z, Z, Z) -9,12,15-octadecatrienoic acid, heptadecanoic acid, methyl 2-methoxybenzoate, methyl 3-chloro-4-methoxybenzoate, methyl heptadecanoate, methyl ester of the acid ( Z, Z) -9,12-octadecadienoic acid, (Z, Z, Z) -9,12,15-octadecatrienoic acid methyl ester, methyl octadecanoate, (Z) -9-octadecenoic acid methyl ester , methyl hexadecanoate, methyl (Z) -9-hexadecenoate, methyl salicylate, octadecanoic acid methyl ester, methyl tetradecanoate, (E) -methyl 2-methylbutenoate, tetradecanoic acid, nal, (Z) - 3,7-dimethyl-2,6-octadi en-1-ol, (Z) -3,7-dimethyl-2,6-octadienyl formate, 2-bromophenol, 2-chlorophenol, octadecenoic acid, C4-18 fatty acids and esters of these fatty acids, acid ( Z) -9-octadecenoic, olein, hexadecanoic acid, 4-methylphenol, nonanoic acid, pentadecanoic acid, 3- (4-methyl-3-pentenyl) -furan, phenol, acid (Z, Z, Z) -5.9 , 12-octadecatrienoic acid, 5-hydroxy-2-methyl-1,4-naphthoquinone, (R) -2,6-dimethyl-5-heptenal, (R) -2,6-dimethyl-5-hepten-1-ol 2-formyl-3-hydroxybenzyl formate, 3-oxo-4-isopropylidene-1-cyclohexene-1-carboxyaldehyde, 3-methyl-2- (3-methylbut-2-enyl) -furan, (S, S) 2,4-dimethylhexan-1-ol, (S, S) -2,4-dimethylheptan-1-ol, (S) -2-methylpentan-1-ol, salicylaldehyde, 4S-4-isopropenyl-3-oxo 1-Cyclohexene-1-carboxyaldehyde, (6E, 1 EO, 14E, 18E) -2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene, octadecanoic acid (E) -3,7-dimethyl-1,3,6-octatriene, xanthine, (Z, E) -3,7,1-trimethyl-2,6,10-dodecatrienal, (Z , Z) -4,8-heptadecadiene, (Z, Z, Z) -4,8,11-heptadecatriene, (Z) -5-tridecene, (Z) -O-tetradecene, (Z) -δ-pentadecene, (Z, Z) -6,9-heptadecadiene, (Z) -7-tetradecene, (Z) -7-pentadecene, (Z) -7-heptadecene, (Z) -7-heptadecene, or mixtures thereof. this.
    In a particular embodiment of the invention, the composition further comprises citral, limonene, pinene, propylene glycol, undecane, decanal, dodecane and / or acetic acid as additional attractive agents.
    As used herein, the term "citral" refers to 3,7-dimethyl-2,6-octadienal, also referred to as the lemone (CAS Registry Number: 5392-40-5), and is one or the other, or a mixture, of a pair of terpenoids of molecular formula C10H10O. Both compounds are double bond isomers. The E isomer is known as geranial or citral A. The Z isomer is known as the neral or citral B. Citral as used herein may be neral, geranial or mixture of the two, for example a 50-50 mixture.
    As used herein, the term "limonene" refers to 1-methyl-4- (1-methylethenyl) -cyclohexene. Limonene is a chiral molecule, and biological sources produce an enantiomer: the main industrial source, citrus, contains D-limonene ((+) - limonene), which is the enantiomer (R) (CAS Registry Number: 5989-27-5). Limonene, as used herein, may be D-limonene as well as the racemic mixture.
    As used herein, the term "pinene" refers to a bicyclic monoterpene chemical compound of the formula (1S, 5S) -2,6,6-trimethylbicyclo [3.1.1] hept-2-ene. In nature, two structural isomers of pinene are found: Γα-pinene (CAS registry number: 80-56-8) and β-pinene, both of which are chiral. Pinene, as used herein, may be Γα-pinene, β-pinene, or a mixture thereof, e.g., a 50-50 mixture. Preferably, pinene is Γα-pinene.
    As used herein, the term "propylene glycol" refers to propane-1,2-diol (also known as 1,2-dihydroxypropane methyl glycol) having the molecular formula C3H8O2. Propylene glycol is a chiral molecule, whose enantiomer (R) has the CAS registry number 4254-14-2, whose enantiomer (S) has the CAS registry number 4254-15-3 and whose racemic mixture has the CAS registry number 57-55-6.
    As used herein, the term "undecane" refers to a compound of the molecular formula C11H24, also known as hendecane and having the CAS Registry Number 1120-21-4.
    As used herein, the term "decanal" refers to a compound of the molecular formula C10H20O, also known as decyl aldehyde or caprinaldehyde, and having the CAS Registry Number 112-31-2.
    As used herein, the term "dodecane" refers to a compound of molecular formula C12H26, also known as dihexyl, bihexyl, adakane 12 or duodecane, and having the CAS Registry Number. 112-40-3.
    As used herein, the term "acetic acid" refers to a compound of molecular formula C2H4O2, also known as ethanoic acid or methane carboxylic acid, having the CAS registry number 64- 19-7.
    In a particular embodiment, the attractant, and optionally the additional attractant or agents for use in the invention, are solubilized in a solvent selected from a group comprising a non-polar solvent (such as pentane), a polar aprotic solvent (such as acetone) and polar protic solvents (such as formic acid, acetic acid, water, butanol, etc.).
    In a particular embodiment, the acari-attracting composition according to the present invention further comprises at least one stabilizer selected from the group consisting of antioxidants, such as glutathione, vitamin C, vitamin A and / or vitamin E; and sequestering agents, such as disodium calcium ethylene diamine tetra-acetate (E385), glucono delta-lactone (E575), sodium gluconate (E576), potassium gluconate (E577), sodium tripolyphosphate , and / or sodium hexametaphosphate (E452i).
    In a particular embodiment, the composition for attracting acari according to the present invention further comprises at least one emulsifier, such as anionic surfactants containing anionic functional groups (such as sulphate, sulphonate, phosphate, and carboxylates). ). Surfactants for use in the present invention, the alkyl sulfates being predominant, include ammonium lauryl sulfate, sodium lauryl sulfate (also known as sodium dodecyl sulfate or SDS), the alkyl ether sulphates related laureth sulfate sodium (also known as sodium lauryl ether sulfate (SLES)) and sodium myreth sulfate, docusate (also known as dioctyl sodium sulfosuccinate), perfluorooctanesulfonate (PFOS), perfluorobutanesulfonate, and linear alkylbenzene sulfonates (LAB ) (including alkyl aryl ether phosphates and alkyl ether phosphate). Other emulsifiers for use in the composition of the invention include carboxylates, for example, alkyl carboxylates (eg, sodium stearate), sodium lauroyl sarcosinate, or carboxylate surfactants such as perfluorononanoate, perfluorooctanoate (PFOA or PFO).
    In a particular embodiment, the acari attractant composition according to the present invention further comprises at least one nonionic surfactant as an emulsifier. Such a nonionic surfactant comprises alkyl ethers of polyoxyethylene glycol; alkyl ethers of polyoxypropylene glycol, polyoxyethylene glycol octylphenol ethers, polyoxyethylene glycol alkylphenol ethers, glycerol alkyl esters, polyoxyethylene glycol, MEA cocamide, cocamide DEA, dodecydimethylamine oxide, and block copolymers of polyethylene glycol and polypropylene glycol (e.g., poloxamers or polyethoxylated amine (POEA)).
    In a particular embodiment, the composition of the invention further comprises at least one perfume such as an essential oil of Mentha citrate, Mentha piperita, Mentha arvensis, Eucalyptol radiata, Vanilla planifolia, Vanilla odorata, or combinations of those -this.
    In a particular embodiment, the attractive composition of the invention is an aqueous composition. In another embodiment, the composition of the invention is an emulsion. Preferably, the composition of the invention does not contain any toxic substance, such as pesticides or acaricides, or at least does not contain these components in an amount sufficient to kill acari.
    As used herein, the term "acari" refers to an arachnid subclass that contains mites and ticks, and is also known as Acarus. In a particular embodiment, the acari concerned by the invention belong to the order Acariformes. In a particular embodiment, the acari belong to the family Pyroglyphidae. In a particular embodiment, acari belongs to the genus Dermatophagoides. In a particular embodiment, acari are dust mites or house dust mites. In a particular embodiment, the acari concerned by the invention comprise any of: Acarus immobilis Griffiths, Acarus siro Linnaeus, Aeroglyphus robustus Banks, Aleuroglyphus ovatus Flock, Amblyomma americanum Linnaeus, Amblyomma cajennense Fabricius, Amblyomma hebraeum Koch, Amblyomma Neumann incisum, Amblyomma maculatum Koch, Amblyomma parvum Aragao, Amblyomma variegatum Fabricius, Amblyseius potentillae Garman, Anocentor nitens Neumann, Archegozetes longisetosus Aoki, Argas persicus Oken, Argas polonicus Latreille, Argas reflexus Latreille, Austrotritia dentate Aoki, Austrotritia ishigakiensis Aoki, Boophilus microplus Canestrini , Carpoglyphus lactis
    Linnaeus, Chelacaropsis moorei, Cheyletus malaccesis, Chortoglyphus arcuatus Herd, Collohmannia gigantea Sellnick, Cosmoglyphus hughesi Samsinak, Dermacentor albipictus Packard, Dermacentor andersoni Stiles, Dermacentor variabilis Say, Dermanyssus gallinae DeGeer, Dermatophagoides farinae Hughes, Dermatophagoides pteronyssinus Trouessart, Gehypochthonius urticinus Berlese, Glycyphagus domesticus DeGeer, Haemaphysalis leachi Audouin, Haemaphysalis leporispalustris Packard, Haemaphysalis longicornis Neumann, Hermannia convexa CL Koch, Histiogaster rotundus Woodring, Histiogaster sp, Histiostoma laboratorium Hughes, Hyalomma anatolicum excavatum Koch, Hyalomma dromedarii Koch, Hyalomma marginatum Koch rufipes, Hyalomma truncatum Koch, Hydronothrus crispus Aoki, Ixodes dammini Say, Ixodes persulcatus Schulze, Ixodes ricinus Linn, Ixodes scapularis Say, Ixodes uriae White, Lardoglyphus konoi Sasa & Asanuma, Limnozetes ciliatus Schrank, Mesotritia okuyamai Aoki, Nehypochthonius porosus Norton & Metz, Neoseiulus womersleyi Shicha, Nothrus palustris Koch, Oribotritia banksi Oudemans, Oribotritia berlesei Michael, Oribotritia chichijimensis Aoki, Oribotritia hermanni Grandjean, Oribotritia storkani Feider & Suciu, Ornithodoros erraticus Walton, Ornithodoros moubata Murray, Ornithodoros porcinus porcinus Walton, Ornithodoros tartakovskyi Olenev, Ornithodoros turicata Duges, Ornithonyssus bacotis, Onrithonyssus syylviarums, Oulenzia sp Parhypochthonius aphidinus Berlese, Perlohmannia sp, Phytoseiulus persimilis Athias-Henriot Platynothrus peltifer Koch, Rhipicephalus appendiculatus Neumann, Rhipicephalus compositus Neumann Rhipicephalus evertsi evertsi Neumann Rhipicephalus pulchellus Neumann, Rhipicephalus sanguineus Latreille, Rhipicephalus simus Koch, Rhizoglyphus robini Claparede, Rhizoglyphus setosus Manson Rhizoglyphus sp Sancassania polyphyllae Zakhvatkin, Sancassania rodriguezi Samsinak, Sancassania shanghaiensis, Sancassania sp Sarcoptes Linnaeus scabiei, Scheloribates sp, Schwiebea araujoae Fain, Schwiebea elongata Banks, Schwiebea imitation Manson, Suidasia medanensis Oudemans, Tortonia sp, Trhypochthoniellus crassus Warburton & Pearce, Trhypochthonius japonicus Aoki, Trhypochthonius silvestris europaeus, Trhypochthonius tectorum Berlese, Tyreophagus sp, Tyroborus Uni Oudemans, Tyrophagus jacobsoni Oudemans, Tyrophagus longior Gervais, Tyrophagus neiswanderi Johnson & Bruce, Tyrophagus perniciosus Zakhvatkin, Tyrophagus putrescentiae Schrank, Tyrophagus imitation Volgin, Uroactinia hirschmanni Hiramatsu, Varroa jacobsoni Oudemans. In a preferred embodiment, the acari concerned by the invention include American dust mites and European dust mites. In a particular embodiment, the acari are selected from the group consisting of Dermatophagoides pteronyssinus (European dust pacariums) and Dermatophagoides farinae (American dust pacariums). It will be understood that, although the European and American terms generally refer to the geographical origin or the prevalence of these mites, no geographical restriction is imposed on the mites preferably concerned by the invention, Dermatophagoides pteronyssinus and Dermatophagoides farinae. being not exclusively confined to Europe or North America.
    The present invention further relates to a sheet to be placed on a surface of an object in which live acari. Before or after placing the sheet on the surface of the object, a composition according to the invention is applied to the sheet, which attracts the acari. After applying the impregnated sheet on the surface of the object, the acari are attracted by the attractive composition of the invention, migrate into the sheet and are thus removed from the object. The sheet, as used in the present invention, has sufficiently large interstices and a thickness large enough to retain the acari. In a particular embodiment, the sheet has a certain degree of porosity, so that the acari can migrate into the sheet. Those skilled in the art will understand that depending on the type of acari to be trapped, the porosity and thickness of the sheet may vary accordingly, since acari sizes may vary depending on the species. In a particular embodiment, by "having interstices sufficiently large to retain acari" is meant that the pore sizes of the sheet may be less than 1 mm to several millimeters, for example 1 mm, 2 mm, 3 mm , 4 mm, 5 mm or more. The thickness of the leaflet may vary accordingly. In a particular embodiment, by "having a sufficiently large thickness to retain acari" is meant that the thickness can reach up to 1 mm or more, for example 1 mm, 2 mm, 3 mm, 4 mm , 5 mm or more. In a particular embodiment, the thickness of the sheet is at least about 1 mm. In another particular embodiment, the thickness of the sheet is between about 1 mm and 5 mm, for example between 1 mm and 4 mm, or between 1 mm and 3 mm. In a preferred embodiment, the thickness of the sheet is 2 mm or about 2 mm.
    In a particular embodiment, the sheet as used herein is a web or fabric, preferably a web or soft fabric. In a particular embodiment, the sheet is a nonwoven fabric or fabric, for example a flexible nonwoven fabric or fabric. In a particular embodiment, the sheet is felt. Felt is well known in the art. As additional guidance, as used herein, the term "felt" refers to a web or nonwoven fabric that is produced by felting, condensing and pressing synthetic and / or non-synthetic fibers. .
    According to the invention, the leaflet is totally or partially formed from natural materials. In one embodiment, the sheet further comprises synthetic materials, such as polyester and / or viscose, for example. In a particular embodiment, the sheet comprises or consists of wool and / or cotton. In a particular embodiment, the sheet comprises at least 10% wool (preferably by weight), for example (approximately) 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, or 100% wool. In a particular embodiment, the sheet comprises at least 10% cotton (preferably by weight), for example (approximately) 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, or 100% cotton. In a particular embodiment, the sheet comprises about 100% wool. In a particular embodiment, the sheet comprises about 100% cotton. The wool as described herein may be obtained from any animal producing wool, such as, but not limited to, sheep and certain other animals, including goat cashmere, goat mohair, musk ox, vicuna, alpaca, camel hair of camelids, and angora of rabbits. The cotton as described herein may be obtained from any plant producing cotton, and more particularly from any plant of the genus Gossypium, more particularly from plants selected from the group consisting of Gossypium hirsutum, Gossypium barbadense, Gossypium arboretum and Gossypium herbaceum.
    In a particular embodiment, a sheet for use in the invention completely or partially made of cotton is advantageous in that it is more easily washed and dried.
    In another particular embodiment, the sheet comprises from 0% to 100% polyester. In another particular embodiment, the sheet comprises from 30% to 100% wool and / or cotton and from 0% to 70% viscose or polyester.
    In a particular embodiment, the sheet for use in the present invention has a density of (about) 5 mg / cm 2 to 70 mg / cm 2, for example (about) 10 mg / cm 2 and 60 mg / cm 2, preferably between (about) 15 mg / cm 2 and 50 mg / cm 2. In a preferred embodiment, the slip has a density of 10 mg / cm 2 or about 20 mg / cm 2.
    In a particular embodiment, the sheet for use in the present invention includes loops that are capable of facilitating the migration of acari from the object to the sheet. In a particular embodiment, said loops have a size in the range of about 1 mm to about 5 cm, preferably about 1 mm to about 1 cm. In a particular embodiment, the loops have a size in the range of about 1 mm to about 5 mm, and preferably about 2 mm to about 3 mm.
    In a particular embodiment, the sheet as used herein has a dark color, for example dark blue. The color can be measured with a variety of techniques known in the art. By way of example, and not limited to, the color can be determined on the basis of the brightness, hue and saturation (or color intensity) parameters. The parameters can be determined individually or collectively according to the CIELCH color scale, in which L * (brightness, or brightness), C * (color intensity or saturation) and h ° (hue) are the parameters representing a polar color space . In a particular embodiment, L * is such that it is <50, preferably L * <60, L * <70, L * <80, or L * <90, in other words the leaflet has a dark. In one embodiment, C * is such that it is> 50, preferably C *> 60, C *> 70, C *> 80, or C *> 90, in other words, the sheet has a color intense. In another embodiment, h ° is such that 180 <h ° <360, preferably 200 <h ° <340, 220 <h <320, or 200 <h <300, in other words the slip has a blue color.
    It will be understood that the ranges or parameter values as defined in this document refer to the range or average value of leaflet parameters, so that non-uniform ranges or parameter values are contemplated. Preferably however, the range or parameter value of the sheet, such as thickness, porosity, density, color, as well as the concentration of the compositions etc. is substantially uniform. Preferably, these parameters do not vary by more than 25%, preferably not more than 10% relative to the average values.
    In a particular embodiment, the present invention further relates to a sheet as defined above, having sufficiently large interstices and a sufficiently large thickness to retain acari, comprising an attractive and non-lethal dose of the composition of the invention. In a particular embodiment, said leaflet does not contain any toxic substance, such as pesticides or acaricides, or at least does not contain these components in amounts sufficient to kill the acari.
    As used in this paper, the terms "trapping" or "holding back" in relation to acari do not necessarily mean that acari are trapped irreversibly. In a particular embodiment, acari that are attracted can enter and exit the leaflet freely. The composition of the invention applied to the sheet is intended to attract and keep or retain the acari in the sheet.
    The present invention further relates to a method for attracting and retaining acari comprising the step of contacting the sheet defined above with an object containing acari or suspected of containing acari. In a particular embodiment, the sheet is brought into contact with said object before or after the application of the acari-attracting composition of the invention. As used herein, "object containing acari or suspected of containing acari" means an object including, for example, beds, comforters, blankets, pillows, mattresses, carpets, armchairs, cushions, upholstered furniture used by humans, as well as objects such as teddy bears, cushions and blankets for dogs, cats and other domestic animals, baskets of dogs and cats, baskets of other domestic animals, niches of dogs and cats, and houses in general.
    As used herein, the term "contacting" normally includes placing the sheet on or under the object. The leaflet can also package said object. Generally and preferably, the sheet is in direct contact with said object. It will be understood that depending on the shape and size of the object, the sheet may otherwise have a different shape or size. One or more sheets may be in contact with an object to be treated.
    When the composition of the invention is applied to the sheet, the sheet preferably has a relative humidity of between about 30% and about 80%, for example between (about) 40 and 80%, preferably between 50 and 75% before to be placed on the object containing acari or suspected of containing acari. Depending on the amount of the composition to be applied per area of the sheet, which in turn depends on the concentration of the active ingredients in the composition, it may be necessary that the sheet is dried before being brought into contact with an object to treat. In a particular embodiment, the drying is carried out passively, for example by passive balancing with ambient humidity conditions. In another embodiment, drying is performed actively, such as, but not limited to, by applying heat to evaporate excessive moisture. In a particular embodiment, the concentration of the active ingredients in the composition of the invention is also selected such that the application of the required amount of the resulting composition in the required dose per unit area automatically results in the relative humidity. required too.
    In a particular embodiment, the sheet comprising the acari-attracting composition of the invention is contacted with said object for a time in the range of about 0 to about 0.5 hours, for a duration in the range of from about 0 to about 1 hour, for a time in the range of about 0 to about 1.5 hours, for a time in the range of about 0 to about 2 hours, or for a duration in the range of about 0 to about 3 hours or more.
    In a preferred embodiment of the invention, the sheet comprising the acari-attracting composition of the invention is contacted with said object for at most about 3 hours (i.e., 3 hours or less), preferably for at most about 2 hours (in other words, for 2 hours or less), preferably for at most about 1 hour (in other words, for 1 hour or less), preferably for at most about 0 , 5 hours (in other words, for 0.5 hours or less).
    In a particular embodiment, the method of the present invention comprises the application on the slip of an attractive and non-fatal dose of the composition of the invention. By "attractive and non-lethal dose" is meant that the active ingredient (s) of the composition of the invention are applied to the sheet in a concentration per area in the range of about 1.82 g / L / m 2 to 1, 82 kg / L / m2, preferably 182 g / L / m2.
    These values and ranges can be applied to each of the individual active ingredients or can be applied to the total combined amount of the active ingredients.
    The dose per area as defined above is preferably obtained by applying a composition comprising the active ingredient or the active ingredients. The compositions as described herein are preferably aqueous compositions. In one embodiment, the compositions as described in the present invention may be emulsions. Preferably, the compositions as described herein do not contain any toxic substance, such as pesticides or acaricides, or at least do not contain these components in amounts sufficient to kill acari. Those skilled in the art will appreciate that the more diluted a composition is, the more it will be necessary to apply it in large quantities to reach the target dose per area. By way of example, and without limitation, if a composition comprises 1 mg / L of attractant and the target dose of said attractant per area is 1 mg / m 2, then 1 L of the composition must be applied by m2. If, on the other hand, a composition comprises 10 mg / L of attractant, and the target dose of said attractant per area is 1 mg / m 2, then 100 ml of the composition should be applied per m 2.
    The present invention further relates to a sheet as defined above, comprising a non-lethal attractive dose of a composition according to the invention.
    In a particular embodiment, the object containing acari, or suspected of containing acari to be contacted, for example covered, with the sheet comprising the acari-attracting composition of the invention, can be advantageously dried before to be put in contact with the leaflet. As used herein, the term "dried" preferably refers to equilibration with ambient humidity conditions. The application of the drying step is thus more beneficial for objects that are exposed to wet conditions. For example, a mattress on which someone has slept may be wetter than the ambient conditions because of the perspiration of the person who slept on it. In a particular embodiment, the object, in particular a mattress, can be dried for several hours. The drying can be carried out passively, for example by passive equilibration with ambient humidity conditions. Alternatively, the drying may be carried out actively, such as, but not limited to, by applying heat to evaporate excessive moisture. In one embodiment, the object to be coated on the sheet as described herein may be dried for at least 1 hour, for example, (about) 1, 2, 3, 4, 5, 6, 7, 8 , 9, 10 hours or more. In a particular embodiment, the object to be coated on the sheet as described herein may be dried for about 0 hours to about 0.5 hours, for about 0 to about 1 hour, for about 0 to about 1, 5 hours, for about 0 to about 2 hours, or about 0 to about 3 hours or more. In a preferred embodiment of the invention, the object to be coated on the sheet as described herein is dried for 3 hours or less, preferably for 2.5 hours or less, preferably for 2 hours or less, of preferably 1.5 hours or less, preferably 1 hour or less, preferably 0.5 hours or less.
    In order to remove or eliminate the acari, the leaflet is removed from the object after being brought into contact with the object containing the mites. The acari residing in the leaflet are thus effectively removed and removed from the object. In order to remove acari from the leaflet, the leaflet can be washed and / or frozen. Both processes result in the destruction of acari.
    During the washing process, the acari will be removed from the leaflet at the same time that it is washed. Any conventional washing process can be applied, such as in a washing machine. Detergent may or may not be added during the washing process. Preferably, detergent is added since it helps to kill acari. It will be understood that those skilled in the art can determine the washing conditions according to the composition of the sheet, since for example some fabrics do not tolerate washing at high temperatures, while others do not tolerate certain types of detergents. .
    Freezing of the sheet can be achieved by submitting the sheet at temperatures below 0 ° C, preferably below about -10 ° C, such as below (about) -15 ° C or -20 ° C. In a particular embodiment, the sheet is frozen for at least 0.50 hours, for example (about) 0.50, 1.00, 1.25, 1.50, 1.75, 2.00, 2, 25, 2.50, 2.75, 3.00 hours or more. Those skilled in the art will understand that depending on the size of the leaflet, longer periods may be necessary for the leaflet to be totally frozen. After freezing, the leaflet can be thawed after which the dead acari can be removed, for example mechanically, for example by shaking the leaflet. In addition, the sheet can be washed as described above.
    The present invention further relates to a kit comprising a sheet as described above and / or a composition according to the invention. In a particular embodiment, said kit thus comprises a sheet already impregnated with the composition according to the invention, at a dose described herein. In another embodiment, the sheet is not yet impregnated with the composition according to the invention. In a particular embodiment, the composition of the invention is further provided in the kit. In addition, the kit may include instructions for applying the composition to the sheet and / or instructions for use, for example applying the sheet to an object containing or suspected of containing acari. These instructions may include the dose to be applied, for example the dose per area, but may also include, in addition or alternatively, directions relating to the application of the composition, for example guidelines relating to the distance at which the composition is to be applied. be sprayed on the slip. The instructions may furthermore, or in a variant, include information relating to the duration during which the leaflet is to be placed on the object to be treated, the drying time of the object before the leaflet is put in contact with the objects. objects, and / or the required drying time or relative humidity of the sheet before bringing it into contact with the object to be treated.
    The composition according to the invention may be provided in a container, for example a dispenser or an applicator, for example in the form of a spray. These distributors or applicators are well known in the art. In a particular embodiment, the applicator is configured for a continuous release of the composition, so that the user can determine the released amount of the composition for example by continuous spraying for a specific duration. In another embodiment, the applicator is a unit dose applicator, such that the released amount of the composition is predetermined, in other words the applicator or dispenser releases a discrete unit dose per application. In a particular embodiment, the dispensing device is a manual atomizer with a spray nozzle control that provides a defined amount of attractive solution per unit area of tissue. Those skilled in the art will appreciate that when spraying with a dispenser, whether continuous or unobtrusive, the distance between the dispenser and the target area can impact the size of the area being covered. For example, when the composition exits the nozzle of the dispenser, the spray may expand proportionally with the distance from the nozzle to cover a wider area as the distance from the target increases, in other words the longer the distance between the dispenser and the target area, the larger the target area will become. Therefore, in order to achieve a particular dose per target area, it may be necessary to position the dispenser at a predetermined distance from the target area, so that, taking into account the enlargement of the spray (e.g. , after leaving the nozzle, the spray widens like a cone), and therefore the dilution over the distance of the amount of composition per area, the predetermined dose per area is satisfied. By way of example, and without limitation, if the dispenser releases a unit dose containing the amount of active ingredient needed to cover 200 cm 2, then the dispenser must be placed at a distance from the target such as 200 cm 2 are covered.
    The dispenser or applicator as described herein may comprise any or a combination of the active ingredients as described herein, either in diluted form or in undiluted form. The dispenser is adapted to release a non-lethal dose for acari of said ingredients per unit area.
    The present invention relates to methods, products, compositions and kits for attracting, trapping, removing and / or eliminating acari, particularly in a home environment. The present invention also relates to the use of these methods, products, compositions and kits for attracting, trapping, removing and / or eliminating acari, particularly in a domestic environment.
    BRIEF DESCRIPTION OF THE DRAWINGS
    Figure 1 is a drawing showing an experimental setup to analyze the spontaneous movement of acari. Number 1 means the Petri dish. Number 2 designates a semicircle. Number 3 represents a group of mites placed in the center of the petri dish.
    Figure 2 is a drawing showing a Berlèse funnel. A funnel containing a mattress or fabric according to the invention containing dust mites disposed under a heat source, such as an electric lamp. Animals fleeing desiccation of the mattress / fabric descend through a filter into a preservative liquid in a receptacle.
    Figure 3 is a histogram showing the comparative efficiencies of different attractants, in different dilutions, relative to Dermatophagoides pteronyssinus. The histogram represents the percentage of mites choosing an attractant rather than water, depending on different attractant compositions (including one or more attractants), in several dilutions (undiluted, 10 "3, 10'6 or 10). '9).
    Figure 4 is a bar graph showing the comparative efficiencies of different attractants, in different dilutions, relative to Dermatophagoides farinae. The histogram represents the percentage of mites choosing an attractant rather than water, depending on different attractant compositions (including one or more attractants), in several dilutions (undiluted, 10 "3, 10'6 or 10). '9).
    Fig. 5 is a graph showing the effect of drying time of mattresses containing dust mites Dermatophagoides pteronyssinus on the effectiveness of compositions containing one or more attractants. The graphs represent the percentage of tissue-trapped mites on which compositions corresponding to the commercially available Acar'up product (at a dilution of 10'6) were sprayed, or on which citral-containing compositions (at a dilution of of 10-6), lavandulol (at a dilution of 10-6) and lavandulol and Tween 60 (both at a concentration of 0.5 x 10-6) were sprayed as attractants, depending on the drying time of the mattress.
    Fig. 6 is a graph showing the effect of the drying time of the mattress containing dust mites Dermatophagoides farinae on the effectiveness of compositions containing one or more attractants. The graphs represent the percentage of tissue-trapped mites on which compositions corresponding to the commercially available Acar'up product (at a dilution of 10'6) were sprayed, or on which citral-containing compositions (at a dilution of of 10-6), lavandulol (at a dilution of 10-6) and lavandulol and Tween 60 (both at a concentration of 0.5 x 10-6) were sprayed as attractants, depending on the drying time of the mattress.
    Figure 7 is a graph showing the attraction efficiency of different compositions containing one or more attractants, depending on the duration of application of the leaflet on an object containing mites Dermatophagoides pteronyssinus. The graphs represent the percentage of tissue-trapped mites on which compositions corresponding to the commercially available Acar'up product (at a dilution of 10 -6) were sprayed, or on which citral-containing compositions (at a dilution of 10-6), lavandulol (at a dilution of 10-6) and lavandulol and Tween 60 (both at a concentration of 0.5 x 10-6) were sprayed as attractants, depending on the duration of exposure to the attractive composition.
    Figure 8 is a graph showing the attraction efficiency of different compositions containing one or more attractants, depending on the duration of application of the leaflet on an object containing dust mites Dermatophagoides farinae. The graphs represent the percentage of tissue-trapped mites on which compositions corresponding to the commercially available Acar'up product (at a dilution of 10 -6) were sprayed, or on which citral-containing compositions (at a dilution of 10 ~ 6), lavandulol (at a dilution of 10-6) and lavandulol and Tween 60 (both at a concentration of 0.5 x 10-6) were sprayed as attractants, depending on the duration of exposure to the attractive composition.
    EXAMPLES
    The present invention is further illustrated by the following examples.
    Example 1: Physical and Chemical Factors Affecting the Choice of Mites
    Purpose of experiments: All experiments are binary choice tests to determine the preference of mites and where they prefer to stay (for at least 30 minutes).
    Breeding: the species studied was Dermatophagoides pteronyssinus, a common dust mite in Eurasian mattresses. The mites are raised in Petri dishes and fed with human dander (skin and beard obtained from the cleaning of electric razors). All mites were grown together under defined conditions (20 ° C and 75% relative humidity). The experiments took place in a room maintained at 20 ° C and 40% relative humidity.
    Materials and methods: A group of mites (20 <n <40) was placed in the center of a petri dish (0 = 5.5 cm) around which two semicircles of felt had been placed (see figure 1). The pieces of felt weighed 70 mg / cm 2, their thickness was 2 mm. A felt is the witness (felt marker), for example impregnated with water; the other felt is the felt with the tested article, for example the felt which is impregnated with a chemical compound tested.
    The mites move spontaneously to one of the two felts. The number of mites that prefer to go to one side or the other has been counted and the distribution of these data has been compared to a situation in which the mites have the choice between two pieces of identical felt (Kolmogorov-Smimov tests) .
    Observations and counting of mites were performed under a binocular microscope (10x magnification). The assembly is lit with a cold lamp (KL 1500 LCD, Schott ®), the lighting is symmetrical and the luminous intensity was 50 Klux. Experimental conditions were regulated in the room (T ° C: 19-22 ° C and 40% RH).
    Experience 1
    Purpose of the experiment: mites can choose between differently moistened felts.
    Materials and Methods: The piece of control felt was at 40% RH (20 ° C, laboratory conditions). The felts tested were at 40, 75, 85 and 100% humidity. To obtain felts at 75% and 85% humidity, they were placed for at least one hour in a room containing a radio-electronic humidifier (Brown B500, accuracy ± 20 ° RH) humidifying the atmosphere to 75 and 85% respectively. The humidity of the room was regularly checked with a thermohygrometer (Oregon). To obtain the felts tested at 100% RH, they were simply immersed in water. Results: The mites were less attracted or repelled by a 40% and 75% moistened felt (Table 1). When the felt was at 80% RH and 100%, it became repellent for dust mites. The same results were obtained with Dermatophagoides farinae.
    Table 1: influence of humidity on the choice of mites.
    SD: statistically different. NS: Not statistically different.
    Experience 2
    Objective of the experiments: Similar experiments were carried out to determine the density of the felt preferred by the mites.
    Materials and methods: the mites chose between felts of different densities. All tested felts and control felts were impregnated with 1 μL of a solution comprising citral at a concentration of about 0.000096% (v / v). The solution used to test the density of the felts was prepared as a 10-fold dilution from a 96% pure citral stock solution (Merck Chemicals Ltd, Cat No. 802489). Results. The felt that was most attractive to mites has a density of 20 mg / cm 2 (Table 2).
    Table 2: influence of the density of felt on the choice of mites.
    SD: statistically different. NS: Not statistically different.
    Experience 3:
    Similar experimental assemblies were made with colored markers and white markers.
    Table 3: Influence of the color of the felt and the color combined with the active compound
    SD: statistically different. NS: Not statistically different. Results: The mites have preferably migrated towards the blue felt. In combination with citral, an 84% migration of mites towards the blue felt was obtained.
    Example 2: Chemical factors influencing trap efficiency
    Experience 1:
    Breeding: the species studied were Dermatophagoides pteronyssinus and
    Dermatophagoides farinae, a domestic mite common in Eurasia mattresses. The mites are raised in petri dishes and fed with human dander (skin and whiskers obtained from the cleaning of electric razors). All mites were grown together under defined conditions (20 ° C and 75% relative humidity). The experiments took place in a room maintained at 20 ° C and 40% relative humidity.
    Objective of the experiments: The objective was to test the trap in conditions similar to those that will be encountered by the user of the trap.
    Materials and methods: the mattresses were built on a smaller scale (15X reduction) than the usual mattresses. The mini mattresses are made of polyurethane and covered by a cotton blanket. They were infested with mites for at least 3 months. The tissue was a felt of 20 mg / cm 2 in the form of a 10 cm x 20 cm rectangle. He was placed on the mini-mattresses. The attractive solution was then sprayed onto the fabric with a sprayer. The fabric was left in place on the mattress for one hour. Meanwhile, the mites have migrated on the felt.
    It is very difficult to directly count the mites hidden in the mattress and in the fabric. Therefore, we used a Berlèse funnel which is a device generally used to separate insects from litter. Here it has been used to separate mites from the mattress or fabric. The Berlèse funnel uses a bulb to heat and dry the mattress, thus driving the mites down, through a sieve, and into a collection container containing food and water.
    The principle is simple: dust mites do not like light or excessive heat. They are attracted by a source of moisture and the smell of food. The mattress or blanket was therefore placed in the funnel (Figure 2). The mites descended in the direction of the container, then into the container. Harvesting of the container containing the mites took place after a day. The mites then had 24 hours to migrate into the collection vessel.
    Since a significant proportion of the population is immobile (mites that moult), trapping is less effective than it would otherwise be and the estimate of the size of the population that is trapped is likely to be skewed. To avoid this deviation and to make a correct evaluation of the populations in the infested mattresses, the mattresses were rigorously brushed with a soft brush at the end of the handling, the immovable mites and the eggs consequently fell into the funnel too. . The fabric has also been rigorously brushed. The funnel of Berlèse was rinsed with ethanol. Thus, the mites that remained on the inner wall of the funnel were driven by ethanol into the collecting vessel. At the end of the experiment, the container contained: food used to attract mites, a small amount of water also used to attract them, mites, and ethanol. The container was emptied into a petri dish and we counted the mites using a binocular. The mite count was performed under a binocular microscope (10X magnification). The assembly is lit with a cold lamp (KL 1500 LCD, Schott ®).
    Various attractive compositions were sprayed on the felt: a solution of lavandulol, a solution of Tween 60, a combination of lavandulol and Tween 60, a solution of citral, and the attractive solution commercially available under the name Acar'up have been compared with different dilutions. Results: The results are presented in Tables 4 and 5, and Figures 3 and 4.
    Table 4: Comparative attraction capacities of five agents in several dilutions, relative to Dermatophagoides pteronyssinus.
    N / A: data unavailable; the results were obtained with a mixture of a solution of lavandulol at a dilution of 1 (L6 and a solution of Tween 60 at a dilution of 10.sup.6 These results are represented in the graph of FIG.
    The diluted lavandulol solutions were prepared from a pure 95% lavandulol stock solution (Sigma-Aldrich, Cat No. 42583). The diluted solutions of Tween 60 were prepared from a stock solution of 100% pure Tween 60 (Merck Chemicals Ltd. Cat No. 822186).
    Table 5: Comparative attraction capacities of five agents in several dilutions, relative to Dermatophagoides farinae.
    8/0: data not available; The results were obtained with a mixture of a solution of lavandulol at a dilution of 1 μl and a solution of Tween 60 at a dilution of 10 ° F. These results are shown in the graph of FIG.
    The diluted lavandulol solutions were prepared from a pure 95% lavandulol stock solution (Sigma-Aldrich, Cat No. 42583). The diluted solutions of Tween 60 were prepared from a stock solution of 100% pure Tween 60 (Merck Chemicals Ltd. Cat No. 822186). From these results, it appears that the most effective attractive solutions are those comprising lavandulol and / or Tween 60, for the two species of acari.
    Experience 2:
    Similar conditions were used to evaluate the influence of several different drying times of the mattress (from 0 hours to 7 hours), to determine if the drying time had an influence on the attraction of mites by the fabric impregnated with an attractive solution containing one or more attractive agents. Results: The corresponding results are shown in Figures 5 and 6.
    Experience 3:
    Similar conditions were used to evaluate the influence of the duration of exposure, meaning the length of time the tissue was placed on the mattress, to determine if the duration of exposure had an influence on the attraction of the mites by the fabric that was impregnated with an attractive solution containing one or more attractants, and to determine if the nature of the chemical agent had an influence on the required exposure time. Several different exposure times were tested (from 0 hours to 7 hours) after drying the mattress for 2 hours. Results: The corresponding results are shown in Figures 7 and 8. The fabric on which the compositions of the invention (in other words containing lavandulol and / or Tween 60) were sprayed appeared to be more effective than the compositions. of the prior art when it was placed on the mattress.
    In addition, as can be seen in FIGS. 7 and 8, compositions containing lavandulol and / or Tween 60 as attractants are more effective upon spraying.
    Example 3 Felt Compositions Influencing Trap Effectiveness
    Objective of the experiments: Similar experiments were carried out to determine the composition of the preferred felt by the mites.
    Materials and methods: the mites were allowed to choose between felts with different compositions. All tested and verified felts were impregnated with 1 μL of a solution comprising Lavandulol (at a final dilution of 0.5 × 10 -6) and Tween 60 (at a final dilution of 0.5 × 10 -6). (see below). Results. The most attractive felt for mites was that of pure cotton.
    Table 6:
    The diluted lavandulol solutions were prepared from a pure 95% lavandulol stock solution (Sigma-Aldrich, Cat No. 42583). The diluted Tween 60 solutions were prepared from a stock solution of 100% pure Tween 60 (Merck Chemicals Ltd. Cat No. 822186).
    Example 4: Elimination of leaf mites
    To remove dust mites from the fabric, the fabric is placed in the washing machine. All mites were killed by water temperatures of 55 ° C or higher (correlated with the results obtained by McDonald & Tovey 1992,
    Andersen &amp; Roesen 1998). According to other authors, it is possible to control dust mites in delicate clothing by washing at low temperature in the presence of an acaricide additive providing a final concentration of 0.03% benzyl benzoate (Bischoff et al., 1998). . After washing, when the fabric is dry, it can still be placed in other places with live mites, the fabric can be impregnated with attractive solution by means of a dispersing device and can be used once again to trap dust mites (Colloff 2009).
    It is also possible to kill mites in the tissue by killing them in a freezer. A temperature of -20 ° C for 30 minutes achieved a mortality of almost 100%, indicating that a conventional household freezer could be used to kill mites in relatively small items such as soft toys, pillows and clothes that can not be washed hot. After passing through the freezer, the user must shake the fabric to get rid of mites from dead dust (results consistent with Colloff 2009). References - Colloff "Dust mites", CSIRO Entomology, 2009, ISBN 9780643065895 - Sonenshine D.E., 1985 "Pheromones and other semiochemicals of the acari" Annual Reviews. 30: 1-28 - Mc Donald L. G., Tovey E. 1992. The role of water temperature and laundry procedures in reducing mite populations and allergen content of bedding. Journal of Allergy and Clinical Immunology Vol. 90, 599-608. - Andersen A. &amp; Roesen J. 1998. House dust mite, Dermatophagoides pteronyssinus, and its allergens: effects of washing. - Bischoff, Fischer, Liebenberg, Kniest. 1998. Mite control with low temperature washing-II Elimination of living mites on clothing. Clinical and Experimental Allergy, Vol 28, 60-65.
    权利要求:
    Claims (15)
    [1]
    A composition for attracting acari comprising an attractant, wherein said attractant is lavandulol in a concentration of 0.0000001% (v / v) to 10% (v / v).
    [2]
    The composition of claim 1, further comprising at least one additional attractant, wherein said additional attractant is polysorbate in a concentration of 0.0000001% (v / v) to 10% (v / v).
    [3]
    3. Composition according to any one of claims 1 or 2, wherein said composition further comprises at least one solvent, at least one stabilizing agent, at least one emulsifier, at least one excipient and / or at least one perfume, of preferably selected from the group consisting of the essential oils of Mentha citrate, Mentha piperita, Mentha arvensis, Eucalyptol radiata, Vanilla planifolia and Vanilla odorata.
    [4]
    4. A method for attracting and retaining acari, comprising the steps of: a) providing a sheet having sufficiently large interstices and a thickness sufficiently large to retain the acari; and b) applying to said slip an attractive, non-fatal dose of the composition of any one of claims 1 to 3.
    [5]
    The method of claim 4, further comprising the steps of contacting said sheet prior to step a) or after step b) with an object suspected of containing acari.
    [6]
    The method of any one of claims 4 or 5 wherein said sheet is contacted with an object suspected of containing acari for at most about 3 hours, preferably at most about 2 hours, preferably at least plus about 1 hour, preferably for at most about 0.5 hour after step b).
    [7]
    7. A process for eliminating acari, comprising the steps of: i) carrying out the process according to any one of claims 4 to 6; and ii) removing said sheet from said object suspected of containing acari.
    [8]
    8. Sheet having sufficiently large interstices and a thickness sufficiently large to retain the acari, comprising a non-lethal attractive dose of the composition according to any one of claims 1 to 3.
    [9]
    A sheet according to claim 8, wherein said sheet comprises 0 to 100% polyester or comprises at least 30% to 100% wool and / or cotton and 0% to 70% viscose and / or polyester .
    [10]
    10. Kit for attracting acari comprising a composition according to any one of claims 1 to 3, and a sheet having sufficiently large interstices and a sufficiently large thickness to retain the acari.
    [11]
    A unit dose applicator comprising a composition according to any one of claims 1 to 3, adapted to release a non-lethal attractive dose of said composition per unit dose per unit area.
    [12]
    The composition, method, sheet, kit or unit dose applicator according to any one of claims 1 to 11, wherein said acari are selected from the group consisting of Dermatophagoides pteronyssinus and Dermatophagoides farinae.
    [13]
    The method of any one of claims 4 to 7, a sheet according to any one of claims 8 or 9 or a unit dose applicator according to claim 11, wherein said non-lethal attractive dose per unit area is in the range of 5 mL / m2 to 2000 mL / m2, preferably 10 mL / m2 to 1000 mL / m2.
    [14]
    14. Use of lavandulol and / or at least one polysorbate to attract acari.
    [15]
    15. Use of a composition according to any one of claims 1 to 3 for attracting acari.
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