• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    A tissue graft suspension device (10) includes a platform member (16), a graft connecting element (18) coupled to the platform member such that a portion of the graft connecting element forms a loop for attachment to a tissue graft (22), and an enclosure member (20) coupled to the loop of the graft connecting element and configured to enclose a biologic material (30). The enclosure member defines an opening configured to receive the biologic material. The graft connecting element and the enclosure member are configured such that, during use, the tissue graft is coupled to the loop and in contact with the enclosure member.
    公开号:AU2013215000A1
    申请号:U2013215000
    申请日:2013-01-31
    公开日:2014-08-21
    发明作者:Alfred Rodrigue Berube Jr.；Steven Mark Bowman；Michael James Perriello；John Albert Slusarz Jr.
    申请人:Smith and Nephew Inc；
    IPC主号:A61F2-08
    专利说明:
    WO 2013/116574 PCT/US2013/024235 IMPLANTABLE BIOLOGIC HOLDER TECHNICAL FIELD This document relates to an implantable biologic holder. BACKGROUND 5 A ligament, such as an anterior cruciate ligament (ACL), that has ruptured and is non repairable may be replaced arthroscopically by a tissue graft. The tissue graft can be natural and harvested from another part of the body. For example, in the case of an ACL repair, the tissue graft can be harvested from a portion of a patellar tendon having so called "bone blocks" at each end, and from the semitendonosis and gracilis. Alternatively, the tissue graft 10 can be formed from synthetic materials or from a combination of synthetic and natural materials. When repairing an ACL, the replacement tissue graft can be implanted by securing one end of the tissue graft in a socket formed in a passage within the femur, and passing the other end of the graft through a passage formed in the tibia. A biologic material, such as a fibrin clot, can be inserted into a ligament or other soft 15 tissue injury site, for example via a cannula, or attached directly to a tissue graft, for example by suturing, to promote healing. The application of a biologic material to an injury site can help promote healing. SUMMARY According to one aspect, a tissue graft suspension device includes a platform 20 member, a graft connecting element coupled to the platform member such that a portion of the graft connecting element forms a loop for attachment to a tissue graft, and an enclosure member coupled to the loop of the graft connecting element and configured to enclose a biologic material. The enclosure member defines an opening configured to receive the biologic material. The graft connecting element and the enclosure member are configured 25 such that, during use, the tissue graft is coupled to the loop and in contact with the enclosure member. Implementations of this aspect may include one or more of the following features. 1 WO 2013/116574 PCT/US2013/024235 For example, the graft connecting element may be a continuous loop of suture. The loop may pass through the opening of the enclosure member. The loop may pass through an attachment element of the enclosure member. The enclosure member may define two openings configured to receive the biologic material. The biologic material may be a fibrin 5 clot. The biologic material may be a platelet rich plasma. The tissue graft suspension device may further include one or more filaments attached to the enclosure member. According to another aspect, a method of securing a tissue graft includes providing a platform member coupled to a graft connecting element, the graft connecting element being coupled to an enclosure member and forming a loop for attachment to the tissue graft, the 10 enclosure member configured to enclose a biologic material, inserting the biologic material through an opening in the enclosure member, attaching the tissue graft to the graft connecting element such that the tissue graft is in contact with the enclosure member, forming a bone tunnel in a bone, and positioning the platform member on a surface of the bone such that at least a portion of the tissue graft is in the bone tunnel. 15 Implementations of this aspect may include one or more of the following features. For example, attaching the tissue graft to the graft connecting element may include looping the tissue graft through the loop of the graft connecting element such that the enclosure member is positioned between two portions of the tissue graft. Attaching the tissue graft to the graft connecting element may include looping the graft connecting element 20 through an opening in a bone block of the tissue graft. The bone tunnel may include a first opening and a second opening. Positioning the platform member on the surface of the bone may include inserting the platform member into the bone tunnel through the first opening and into the bone tunnel, moving the platform member through the tunnel and out the second opening, and positioning the platform member over the second opening with the graft 25 connecting element extending into the bone tunnel such that a first portion of the tissue graft attached to the graft connecting element is in the tunnel and a second portion of the tissue graft extends out of the first opening. According to yet another aspect, a scaffold for receiving a biologic material includes a central portion impregnated with a biologic material, the central portion comprising 30 filaments arranged in a weave pattern, and a guide portion attached to an edge of the central 2 WO 2013/116574 PCT/US2013/024235 portion, the guide portion comprising one or more filaments. The scaffold is configured to be inserted into a tear in soft tissue. Implementations of this aspect may include one or more of the following features. For example, the tear in soft tissue may be a meniscal tear. The guide portion may 5 include a first guide portion attached to a first edge of the central portion, and a second guide portion attached to a second edge of the central portion, the second edge being opposite the first edge. The guide portion may include one or more filaments extending out from the weave pattern of the central portion. According to a further aspect, a method of repairing a soft tissue tear includes 10 providing a scaffold comprising a central portion and a guide portion, the central portion comprising filaments arranged in a weave pattern, impregnating the central portion of the scaffold with a biologic material, inserting an edge of the scaffold into the soft tissue tear, and moving the central portion of the scaffold within the soft tissue tear into a final position by manipulating the guide portion. 15 Implementations of this aspect may include one or more of the following features. For example, the soft tissue may be a meniscus. Impregnating the central portion of the scaffold with a biologic material may include forming at least one of a fibrin clot or a platelet rich plasma around the central portion. Impregnating the central portion of the scaffold may include pressing the central portion into at least one of a fibrin clot or a platelet 20 rich plasma. The details of one or more implementations are set forth in the accompanying drawings and the description below. Other features, aspects, and advantages will become apparent from the description, the drawings, and the claims. 25 BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1A is a perspective view of a graft attachment device implanted within a femur. FIG. 1B is a perspective view of an alternative implantation of the graft attachment device within the femur. FIG. 2 is a perspective view of the graft attachment device. 30 FIGS. 3A-3B are perspective views of the graft attachment device coupled to a tissue graft. 3 WO 2013/116574 PCT/US2013/024235 FIG. 4 is a perspective view of an alternative graft attachment device coupled to an alternative tissue graft. FIG. 5 is a top view of a suture scaffold implanted within a meniscal tear. FIG. 6 is a side view of the suture scaffold. 5 FIG. 7A is a perspective view of the suture scaffold implanted within the meniscal tear. FIG. 7B is another top view of the suture scaffold implanted within the meniscal tear. FIG. 7C is a cross-sectional perspective view of the suture scaffold of Fig. 7B taken along the line 7C-7C. 10 DETAILED DESCRIPTION This document describes examples of an implantable enclosure member and an implantable scaffold that can hold a biologic material, for example a fibrin clot, and be positioned within a ligament or other soft tissue repair site such that the biologic material comes in contact with the ligament or other soft tissue. 15 Referring to FIG. 1A, a graft attachment device 10 is implanted during, for example, an anterior cruciate ligament (ACL) repair and reconstruction procedure, and is positioned within a femoral tunnel 12a of a femur 14. In some cases, the graft attachment device 10 can be positioned within a shorter femoral tunnel 12b (FIG. 1B). The graft attachment device 10 includes a platform member 16, a graft connecting element 18, and an enclosure member 20, 20 and can be coupled to a tissue graft 22, for example a semitendonosis and gracilis graft. The femoral tunnel 12a, 12b can receive one end of the graft 22 while a tibial tunnel 24 located within a tibia 26 can receive the other end. Referring also to FIG. 2, the enclosure member 20 of the graft attachment device 10 is generally a sac-like structure that can be made from a braided or woven mesh of suture 25 material, such as #5 Ultrabraid suture, a natural material, such as collagen, or a combination thereof. The enclosure member 20 has two openings 28a, 28b positioned on opposite portions of the enclosure member 20. The openings 28a, 28b can allow the enclosure member 20 to receive and hold a biologic material 30 as discussed further below. Alternatively, the enclosure member can have a single opening, more than two openings, or 30 no openings. A plurality of filaments, threads, sutures, or the like can be attached to portions 4 WO 2013/116574 PCT/US2013/024235 of the enclosure member 20 to help, for example, couple the enclosure member 20 to other parts of the graft attachment device 10 or the tissue graft 22. In some cases, the enclosure member 20 can be a continuous band of suture material. Alternatively, the enclosure member 20 can be a scaffold-like structure configured to be impregnated with the biologic 5 material 30. The graft connecting element 18 of the graft attachment device 10 couples the tissue graft 22 (FIGS. 1A-IB) to the graft attachment device 10 as discussed further below. As shown in FIG. 2, the graft connecting element 18 can be a continuous loop of suture, such as #5 Ultrabraid suture, or other material, such as polyester, that is looped through openings 10 28a, 28b of the enclosure member 20 and openings 32 of the platform member 16 to couple the enclosure member 20 to the platform member 16. Alternatively, or additionally, the graft connecting element 18 can be coupled to the enclosure member 20 and the platform member 16 via various filaments and other attachment elements (not shown). The platform member 16 of the graft attachment device 10 can be positioned on a 15 cortical surface of the femur 14 (FIGS. 1A-1B) and helps secure the graft attachment device 10 and the tissue graft 22 within the femoral tunnel 12a, 12b. Various sutures can be looped through one or more openings 32 of the platform member 16 and used by a surgeon to pull the platform member 16 through the femoral tunnel 12a, 12b and position the platform member 16 on the cortical surface of the femur 14 as desired. 20 In addition to various filaments, threads, sutures, or the like, the graft attachment device 10 can include components formed from any biocompatible material or a combination of biocompatible materials, such as certain metal alloys and polymers. Components of the graft attachment device 10 can include non-absorbable materials such as PEEK or Acetal. Alternatively, or additionally, components of the graft attachment device 10 can include 25 bioabsorbable materials such as PLLA. During surgery, a surgeon inserts the biologic material 30 into the enclosure member 20 via the opening 28a, 28b prior to attachment of the tissue graft 22. The biologic material 30 can be a fibrin clot or any other material that facilitates ligament or tissue repair. For example, the biologic material 30 can include any biocompatible material or a combination 30 of biocompatible materials such as, but not limited to, platelet rich plasma (PRP), hyaluronic acid (HA), growth factors (e.g. PDGF, FGF, BMP, GDF-5, and other members of the TGF-p 5 WO 2013/116574 PCT/US2013/024235 superfamily), autologous tissue fragments, and pharmacologic agents (e.g. anti-inflammatory and/or analgesic). Alternatively, or additionally, the biologic material 30 can be pressed into a surface of the enclosure member 20 such that the biologic material 30 is formed around the surface. The enclosure member 20 can be pre-attached to the graft attachment device 10 5 during manufacture. Alternatively, the enclosure member 20 can be coupled to the graft attachment device 10 prior to or following insertion of the biologic material 30 into the enclosure member 20. In some cases, the surgeon can close the openings 28a, 28b, for example using sutures, to prevent the biologic material 30 from coming out of the enclosure member 20. 10 The biologic material 30 can help promote healing following surgery, such as ACL reconstruction. For example, the fibrin clot, a paste-like material typically prepared from a patient's blood, can enhance healing between graft bundles as well as between the graft bundles and bone by releasing various growth factors and chemical substances that promote healing. 15 Referring to FIGS. 3A and 3B, following insertion of the biologic material 30 into the enclosure member 20, the surgeon can attach the tissue graft 22, which can comprise semitendinosus and gracilis grafts or two halves of a semitendinosus graft, to the graft attachment device 10 by passing the graft 22 through the graft connecting element 18 and doubling over to produce, for example, a quadrupled bundle. During the attachment process, 20 the tissue graft 22 can be folded over the enclosure member 20 such that the biologic material 30 contained within the enclosure member 20 comes in contact with an inner surface of the folded-over tissue graft 22. In some cases, the enclosure member 20 can be positioned proximate an outer surface of the folded-over tissue graft 22. Referring to FIG. 4, in some cases a tissue graft 34 having a bone block 36 can be 25 attached to a graft attachment device 38. The bone block 36 is generally shaped and sized in close conformity with the femoral tunnel 12a, 12b to promote optimal healing. The tissue graft 34, for example a patellar tendon graft, can be attached to the graft attachment device 38 by looping a graft connection element 40 through an opening 42 in the bone block 36. During this process, the graft attachment device 38 can also be looped through an attachment 30 portion 44 of a enclosure member 46. The biologic material 30 can be inserted into the enclosure member 46 as described above. Following attachment of the tissue graft 34 and 6 WO 2013/116574 PCT/US2013/024235 the enclosure member 46 to the graft attachment device 38, the enclosure member 46 is generally positioned below the bone block 36 and proximate a ligament portion of the tissue graft 34. Prior to implanting the graft attachment devices 10, 38 and the respectively attached 5 tissue grafts 22, 34, the femoral tunnel 12a, 12b can be drilled from an intercondylar notch of the femur 14 towards the cortical surface of the femur 14. The tibial tunnel 24 can be drilled from an anterior region of the tibia 26 towards the intercondylar notch. During implantation, the graft attachment device 10, 38, and the attached tissue graft 22, 34, respectively, can be positioned within the femoral tunnel 12a, 12b using lead sutures 10 (not shown) that can be looped through one or more openings 32 of the platform member 16. For example, the lead sutures are passed through the femoral tunnel 12a, 12b from an opening near the intercondylar notch and used to pull the graft attachment device 10, 38 through the femoral tunnel 12a, 12b and towards an opening near the cortical surface of the femur 14. After the platform member 16 exits the femoral tunnel 12a, 12b through the 15 opening near the cortical surface, the lead sutures can be used to flip and position the platform member 16 so that the member 16 lies flat against the cortical surface of the femur 14 and at least a portion of the tissue graft 22, 34 is positioned within the femoral tunnel 12a, 12b. A distal end of the attached tissue graft 22, 34 can extend out of the opening near the intercondylar notch. 20 In addition to promoting healing at a ligament injury site, such as following an ACL reconstruction surgery, the biologic material 30 can help enhance healing at a soft tissue injury site, for example in a meniscal tissue repair. In a meniscal tear repair procedure, a fibrin clot or PRP, for example, can be inserted into a meniscal tear to promote healing, especially in meniscal regions of low vascularity such as red-white and white-white regions 25 of a meniscus. Referring to FIGS. 5 and 6, a suture scaffold 50 is designed to hold the biologic material 30 and can be inserted into a tear 52 in a meniscus 54 to promote healing. The suture scaffold 50 includes a central portion 56 and one or more guide portions 58, 60 proximately attached to a border or edge region of the central portion 56. 30 The central portion 56 of the suture scaffold 50 is configured to be impregnated with the biologic material 30 so that the biologic material 30 may be readily delivered and secured 7 WO 2013/116574 PCT/US2013/024235 to the soft tissue injury site during surgery. For example, the central portion 56 can include a plurality of horizontally oriented sutures 62 and transversely oriented sutures 64 that are woven together to form a mesh surface. The horizontal and transverse sutures 62, 64 of the central portion 56 can be arranged such that the resulting mesh is sufficiently sparse to allow 5 a biologic material to be pushed at least partially through its surface, yet dense enough to hold the pushed-through biologic material in place. In some implementations, the sutures 62, 64 can have a rough surface texture, or other surface properties, that aids in holding the pushed-through biologic material in place. In use, the surgeon can impregnate the central portion 56 with the biologic material 30, for example a fibrin clot, by pressing the biologic 10 material 30 into the mesh surface of the central portion 56. Horizontal sutures 62 and transverse sutures 64 of the central portion 56 hold the biologic material 30 within the central portion 56 and can impart increased structural integrity to the biologic material 30 to aid in handling and delivery of the material 30. Alternatively, or additionally, the biologic material 30 can be chemically formed around the central portion 56, for example through coagulation 15 of fibrinogen by thrombin. As shown in FIG. 6, one or more guide portions 58, 60 of the suture scaffold 50 are attached to an edge region of the central portion 56 and can help position the central portion 56 and the impregnated biologic material 30 at a desired location within the tear 52 (FIG. 5). For example, the guide portions 58, 60 can include one or more horizontal sutures 62 20 extending out from opposing ends of the woven mesh surface of the central portion 56. Alternatively, or additionally, the guide portions 58, 60 can include one or more transverse sutures 64 extending out from opposing ends of the woven mesh surface of the central portion 56. In some cases, the guide portions 58, 60 can be absorbable or non-absorbable structures that are separately attached to one or more edge regions of the central portion 56. 25 During a meniscal tear repair procedure, as shown in FIGS. 7A-7C, the surgeon can implant the suture scaffold 50 and the impregnated biologic material 30 into the tear 52. For example, the surgeon can guide a leading edge 66 (FIG. 7C) of the suture scaffold 50 into the tear 52 until the suture scaffold 50 and the biologic material 30 are generally positioned at an appropriate depth within the tear 52. Then, the surgeon can move the central portion 56 and 30 the impregnated biologic material 30 to a final desired position within the tear 52 by pulling, pushing, and otherwise manipulating the guide portions 58, 60 until the desired positioning 8 WO 2013/116574 PCT/US2013/024235 of the biologic material 30 is obtained. After the desired positioning of the biologic material 30 is obtained, the guide portions 58, 60 can be removed, for example by cutting, or left in place. In some cases, the entire suture scaffold 50 can be removed, leaving only the biologic material 30 in place within the meniscal tear 52. Implantation of the biologic material 30 5 into the meniscal tear 52 can be used with other meniscal tear repair procedures and tools to enhance healing at the repair site. While this document contains many specific implementation details, these should not be construed as limitations on the scope of any implementations or of what may be claimed, but rather as descriptions of features specific to particular implementations of particular 10 implementations. Certain features that are described in this document in the context of separate implementations can also be implemented in combination in a single implementation. Conversely, various features that are described in the context of a single implementation can also be implemented in multiple implementations separately or in any suitable subcombination. Moreover, although features may be described above as acting in 15 certain combinations and even initially claimed as such, one or more features from a claimed combination can in some cases be excised from the combination, and the claimed combination may be directed to a subcombination or variation of a subcombination. Thus, particular implementations of the subject matter have been described. Other implementations are within the scope of the following claims. 20 What is claimed is: 9
    权利要求:
    Claims (20)
    [1] 1. A tissue graft suspension device, comprising: a platform member; 5 a graft connecting element coupled to the platform member such that a portion of the graft connecting element forms a loop for attachment to a tissue graft; and an enclosure member coupled to the loop of the graft connecting element and configured to enclose a biologic material, the enclosure member defining an opening configured to receive the biologic material; 10 wherein the graft connecting element and the enclosure member are configured such that, during use, the tissue graft is coupled to the loop and in contact with the enclosure member.
    [2] 2. The device of claim 1, wherein the graft connecting element is a continuous loop of 15 suture.
    [3] 3. The device of claim 1, wherein the loop passes through the opening of the enclosure member. 20
    [4] 4. The device of claim 1, wherein the loop passes through an attachment element of the enclosure member.
    [5] 5. The device of claim 1, wherein the enclosure member defines two openings configured to receive the biologic material. 25
    [6] 6. The device of claim 1, wherein the biologic material is a fibrin clot.
    [7] 7. The device of claim 1, wherein the biologic material is a platelet rich plasma. 30
    [8] 8. The device of claim 1, further comprising one or more filaments attached to the enclosure member. 10 WO 2013/116574 PCT/US2013/024235
    [9] 9. A method of securing a tissue graft comprising: providing a platform member coupled to a graft connecting element, the graft connecting element being coupled to an enclosure member and forming a loop for attachment 5 to the tissue graft, the enclosure member configured to enclose a biologic material; inserting the biologic material through an opening in the enclosure member; attaching the tissue graft to the graft connecting element such that the tissue graft is in contact with the enclosure member; forming a bone tunnel in a bone; and 10 positioning the platform member on a surface of the bone such that at least a portion of the tissue graft is in the bone tunnel.
    [10] 10. The method of claim 9, wherein attaching the tissue graft to the graft connecting element comprises looping the tissue graft through the loop of the graft connecting element 15 such that the enclosure member is positioned between two portions of the tissue graft.
    [11] 11. The method of claim 9, wherein attaching the tissue graft to the graft connecting element comprises looping the graft connecting element through an opening in a bone block of the tissue graft. 20
    [12] 12. The method of claim 9, wherein the bone tunnel includes a first opening and a second opening and positioning the platform member on the surface of the bone comprises: inserting the platform member into the bone tunnel through the first opening and into the bone tunnel; 25 moving the platform member through the tunnel, and out the second opening; and positioning the platform member over the second opening with the graft connecting element extending into the bone tunnel such that a first portion of the tissue graft attached to the graft connecting element is in the tunnel and a second portion of the tissue graft extends out of the first opening. 30
    [13] 13. A scaffold for receiving a biologic material, comprising: 11 WO 2013/116574 PCT/US2013/024235 a central portion impregnated with a biologic material, the central portion comprising filaments arranged in a weave pattern; and a guide portion attached to an edge of the central portion, the guide portion comprising one or more filaments; 5 wherein the scaffold is configured to be inserted into a tear in soft tissue;
    [14] 14. The scaffold of claim 13, wherein the tear in soft tissue is a meniscal tear.
    [15] 15. The scaffold of claim 13, wherein the guide portion comprises a first guide portion 10 attached to a first edge of the central portion, and a second guide portion attached to a second edge of the central portion, the second edge being opposite the first edge.
    [16] 16. The scaffold of claim 13, wherein the guide portion comprises one or more filaments extending out from the weave pattern of the central portion. 15
    [17] 17. A method of repairing a soft tissue tear, comprising: providing a scaffold comprising a central portion and a guide portion, the central portion comprising filaments arranged in a weave pattern; impregnating the central portion of the scaffold with a biologic material; 20 inserting an edge of the scaffold into the soft tissue tear; and moving the central portion of the scaffold within the soft tissue tear into a final position by manipulating the guide portion.
    [18] 18. The method of claim 17, wherein the soft tissue is a meniscus. 25
    [19] 19. The method of claim 17, wherein impregnating the central portion of the scaffold with a biologic material comprises forming at least one of a fibrin clot or a platelet rich plasma around the central portion. 12 WO 2013/116574 PCT/US2013/024235
    [20] 20. The method of claim 17, wherein impregnating the central portion of the scaffold comprises pressing the central portion into at least one of a fibrin clot or a platelet rich plasma. 13
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    同族专利:
    公开号 | 公开日
    KR20140121842A|2014-10-16|
    ZA201405600B|2016-08-31|
    IN2014DN06485A|2015-06-12|
    JP2015509032A|2015-03-26|
    CN104379091B|2017-04-19|
    EP2809268A1|2014-12-10|
    RU2014133464A|2016-03-27|
    US20160058550A1|2016-03-03|
    CN104379091A|2015-02-25|
    US9913710B2|2018-03-13|
    EP2809268B1|2017-11-01|
    WO2013116574A1|2013-08-08|
    US9204959B2|2015-12-08|
    AU2013215000B2|2018-01-18|
    JP6141882B2|2017-06-07|
    US20130204367A1|2013-08-08|
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    法律状态:
    2018-05-17| FGA| Letters patent sealed or granted (standard patent)|
    2019-08-29| MK14| Patent ceased section 143(a) (annual fees not paid) or expired|
    优先权:
    申请号 | 申请日 | 专利标题
    US13/365,000||2012-02-02||
    US13/365,000|US9204959B2|2012-02-02|2012-02-02|Implantable biologic holder|
    PCT/US2013/024235|WO2013116574A1|2012-02-02|2013-01-31|Implantable biologic holder|
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