• 专利附录
  • 专利说明
  • 权利要求
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    • 专利摘要:
    The present technology is directed generally to a lead anchor for positioning and securing spinal cord modulation leads and associated systems and methods. In at least some contexts, the lead anchor includes a central lumen surrounded by a restriction feature. The restriction feature can interface with a tightening screw or other actuator and can be configured to provide a radial compressive fit around the lead body. In some embodiments, the clamp can be disengaged upon twisting or other unlocking motion to release the lead.
    公开号:AU2013211937A1
    申请号:U2013211937
    申请日:2013-01-25
    公开日:2014-09-11
    发明作者:Yougandh Chitre；Ellen Moore；Jon Parker；Vivek Sharma；Daniel VILLAMIL；Andre B. Walker
    申请人:Nevro Corp；
    IPC主号:A61N1-02
    专利说明:
    WO 2013/112920 PCT/US2013/023275 LEAD ANCHORS AND ASSOCIATED SYSTEMS AND METHODS CROSS-REFERENCE TO RELATED APPLICATION [0001] The present application claims priority to U.S. Provisional Application 61/590,769, filed on January 25, 2012 and incorporated herein by reference. TECHNICAL FIELD [0001] The present technology is directed generally to lead anchors for positioning and securing spinal cord modulation leads or other signal delivery elements as well as associated systems and methods. BACKGROUND [0002] Neurological stimulators have been developed to treat pain, movement disorders, functional disorders, spasticity, cancer, cardiac disorders, and various other medical conditions. Implantable neurological stimulation systems generally have an implantable pulse generator and one or more leads that deliver electrical pulses to neurological tissue or muscle tissue. For example, several neurological stimulation systems for spinal cord stimulation (SCS) have cylindrical leads that include a lead body with a circular cross-sectional shape and multiple conductive rings spaced apart from each other at the distal end of the lead body. The conductive rings operate as individual electrodes or contacts and the SCS leads are typically implanted either surgically or percutaneously through a large needle inserted into the epidural space, often with the assistance of a stylet. [0003] Once implanted, the pulse generator applies electrical pulses to the electrodes, which in turn modify the function of the patient's nervous system, such as by altering the patient's responsiveness to sensory stimuli and/or altering the patient's motor-circuit output. During pain treatment, the pulse generator applies electrical pulses to the electrodes, which in turn can generate sensations that mask or otherwise alter the patient's sensation of pain. For example, in many cases, patients report a tingling or paresthesia that is perceived as more pleasant and/or less uncomfortable -1- WO 2013/112920 PCT/US2013/023275 than the underlying pain sensation. In other cases, the patients can report pain relief without paresthesia or other sensations. [0004] In any of the foregoing systems, it is important for the practitioner to accurately position and anchor the leads in order to provide effective therapy. Existing lead anchors can negatively impact lead performance and/or reliability when they allow the lead body to slide or otherwise change position. The movement of the lead body relative to the lead anchor can reduce the accuracy with which the stimulation is provided, thus limiting the effectiveness of the therapy. In some cases, the leads must be securely fixed but still repositionable if the practitioner determines that a different position would provide more effective therapy. Reliable retention of the leads or other signal delivery elements in the pulse generator, lead extension components, as well as components that may releasably couple a lead or other signal delivery element to an external stimulator (such as those disclosed in co-pending U.S. Patent Application Publication No. 2011/0071593 to Parker et al., which is hereby incorporated by reference in its entirety) is also important in such systems. As a result, there exists a need for a lead retention mechanism, such as a lead anchor, etc, that mitigates lead movement while providing the ability to subsequently reposition the lead. BRIEF DESCRIPTION OF THE DRAWINGS [0005] Figure 1A is a partially schematic illustration of an implantable spinal cord modulation system positioned at a patient's spine to deliver therapeutic signals in accordance with several embodiments of the present technology. [0006] Figure 1B is a partially schematic, cross-sectional illustration of a patient's spine, illustrating representative locations for an implanted lead in accordance with embodiments of the present technology. [0007] Figure 2A is an isometric illustration of a lead anchor configured in accordance with embodiments of the present technology. [0008] Figure 2B is an isometric illustration of a locking mechanism for securing a lead anchor in accordance with embodiments of the present technology. [0009] Figure 2C is an isometric illustration of a restriction member configured in accordance with an embodiment of the presently disclosed technology. -2- WO 2013/112920 PCT/US2013/023275 [0010] Figures 3 and 4 illustrate embodiments of lead anchors having multiple apertures in accordance with further embodiments of the technology. [0011] Figure 5A is partially schematic, isometric illustration of a lead securement device having a press member in accordance with an embodiment of the present technology. [0012] Figure 5B is a partially schematic, cross-sectional illustration having an embodiment of the lead securement device shown in Figure 5A. [0013] Figure 6A is a partially schematic, isometric illustration of a lead securement device having a press member in accordance with another embodiment of the present technology. [0014] Figure 6B is a partially schematic, cross-sectional illustration of an embodiment of the lead securement device shown in Figure 6A. [0015] Figure 6C is a partially schematic, cross-sectional illustration of a lead anchor that includes a lead securement device of the type shown in Figures 6A and 6B. [0016] Figure 6D is a partially schematic, isometric illustration of an embodiment of a lead anchor shown in Figure 6C. [0017] Figure 6E is a partially schematic, isometric illustration of an embodiment of the lead anchor shown in Figures 6C and 6D. [0018] Figure 7A is a partially schematic, isometric illustration of a lead securement device having a collet arrangement in accordance with another embodiment of the present technology. [0019] Figure 7B is a partially schematic, isometric illustration of a portion of the lead securement device shown in Figure 7A, having collet fingers in accordance with an embodiment of the present technology. [0020] Figure 7C is a partially schematic, cross-sectional illustration of the lead securement device shown in Figure 7A. [0021] Figure 7D is a partially schematic, cross-sectional illustration of a lead securement device having tapered surfaces in accordance with another embodiment of the present technology. -3- WO 2013/112920 PCT/US2013/023275 [0022] Figures 8A-8C are partially schematic, isometric illustrations of a device having rotary and lock features in accordance with an embodiment of the present technology. [0023] Figures 9A-9C are partially schematic, isometric illustrations of a securement device having linear engagement and lock features in accordance with another embodiment of the present technology. [0024] Figure 9D and 9E are partially schematic, cross-sectional illustrations of a portion of the device shown in Figures 9A-9C. [0025] Figures 1OA-10D are partially schematic, isometric illustrations of a lead securement device having a clamshell configuration in accordance with an embodiment of the present technology. [0026] Figures 11A-11E are partially schematic, isometric illustrations of a lead securement device having a twist and lock configuration in accordance with another embodiment of the present technology. DETAILED DESCRIPTION [0027] The present technology is directed generally to lead anchors for positioning and securing spinal cord modulation leads or other signal delivery elements as well as associated systems and methods. In at least some contexts, the lead anchor includes a central lumen surrounded or partially surrounded by a restriction feature. The restriction feature can interface with a tightening screw and can be configured to provide a compressive fit on or around the lead body. In some embodiments, the restriction feature can be disengaged by twisting or otherwise imparting an unlocking motion to release the lead. Other embodiments may eliminate particular components or procedures described herein. A person of ordinary skill in the relevant art, therefore, will understand that the present technology may include other embodiments with additional elements, and/or may include other embodiments without several of the features shown and described below with reference to Figures 1A-11E. Several aspects of overall systems in accordance with the disclosed technology are described with reference to Figures 1A and 11B, and features specific to representative lead anchors are then discussed with reference to Figures 2A-1 1 E. -4- WO 2013/112920 PCT/US2013/023275 [0028] Figure 1A schematically illustrates a representative patient system 100 for providing relief from chronic pain and/or other conditions, arranged relative to the general anatomy of a patient's spinal cord 191. The overall patient system 100 can include a signal delivery device 110, which may be implanted within a patient 190, typically at or near the patient's midline 189, and which is coupled to a pulse generator 101. The signal delivery device 110 carries features for delivering therapy to the patient 190 after implantation. The pulse generator 101 can be connected directly to the signal delivery device 110, or it can be coupled to the signal delivery device 110 via a signal link 102 (e.g., an extension). In a further representative embodiment, the signal delivery device 110 can include an elongated lead or lead body 111. As used herein, the terms "lead" and "lead body" include any of a number of suitable substrates and/or support members that carry devices for providing therapy signals to the patient 190. For example, the lead 111 can include one or more electrodes or electrical contacts at a distal end that direct electrical signals into the patient's tissue, such as to provide for patient relief. As will be described in further detail below with reference to Figures 2A-1 1 E, a portion of the lead 111 can be anchored to the patient. [0029] The pulse generator 101 can transmit signals (e.g., electrical signals) to the signal delivery device 110 that up-regulate (e.g., stimulate or excite) and/or down regulate (e.g., block or suppress) target nerves. As used herein, and unless otherwise noted, the terms "modulate" and "modulation" refer generally to signals that have either type of the foregoing effects on the target nerves. The pulse generator 101 can include a machine-readable (e.g., computer-readable) medium containing instructions for generating and transmitting suitable therapy signals. The pulse generator 101 and/or other elements of the system 100 can include one or more processors 107, memories 108 and/or input/output devices. Accordingly, the process of providing modulation signals, providing guidance information for locating the signal delivery device 110, and/or executing other associated functions can be performed by computer-executable instructions contained by computer-readable media located at the pulse generator 101 and/or other system components. The pulse generator 101 can include multiple portions, elements, and/or subsystems (e.g., for directing signals in accordance with multiple signal delivery parameters), carried in a single housing, as shown in Figure 1A, or in multiple housings. -5- WO 2013/112920 PCT/US2013/023275 [0030] In some embodiments, the pulse generator 101 can obtain power to generate the therapy signals from an external power source 103. The external power source 103 can transmit power to the implanted pulse generator 101 using electromagnetic induction (e.g., RF signals). For example, the external power source 103 can include an external coil 104 that communicates with a corresponding internal coil (not shown) within the implantable pulse generator 101. The external power source 103 can be portable for ease of use. [0031] During at least some procedures, an external programmer 105 (e.g., a trial modulator) can be coupled to the signal delivery device 110 during an initial procedure, prior to implanting the pulse generator 101. For example, a practitioner (e.g., a physician and/or a company representative) can use the external programmer 105 to vary the modulation parameters provided to the signal delivery device 110 in real time, and select optimal or particularly efficacious parameters. These parameters can include the location from which the electrical signals are emitted, as well as the characteristics of the electrical signals provided to the signal delivery device 110. In a typical process, the practitioner uses a cable assembly 120 to temporarily connect the external programmer 105 to the signal delivery device 110. The practitioner can test the efficacy of the signal delivery device 110 in an initial position. The practitioner can then disconnect the cable assembly 120 (e.g., at a connector 122), reposition the signal delivery device 110, and reapply the electrical modulation. This process can be performed iteratively until the practitioner obtains the desired position for the signal delivery device 110. Optionally, the practitioner may move the partially implanted signal delivery element 110 without disconnecting the cable assembly 120. [0032] After a trial period with the external programmer 105, the practitioner can implant the implantable pulse generator 101 within the patient 190 for longer term treatment. The signal delivery parameters provided by the pulse generator 101 can still be updated after the pulse generator 101 is implanted, via a wireless physician's programmer 117 (e.g., a physician's remote) and/or a wireless patient programmer 106 (e.g., a patient remote). Generally, the patient 190 has control over fewer parameters than does the practitioner. In other embodiments, the iterative trial process described above can be eliminated, e.g., when an initial implant provides a suitable therapeutic effect without the need for a trial process. -6- WO 2013/112920 PCT/US2013/023275 [0033] Figure 1B is a cross-sectional illustration of the spinal cord 191 and an adjacent vertebra 195 (based generally on information from Crossman and Neary, "Neuroanatomy," 1995 (published by Churchill Livingstone)), along with multiple signal delivery devices 110 (shown as signal delivery devices 110a-d) implanted at representative locations. For purposes of illustration, multiple signal delivery devices 110 are shown in Figure 1B implanted in a single patient. In actual use, any given patient will likely receive fewer than all the signal delivery devices 110 shown in Figure 1B. [0034] The spinal cord 191 is situated within a vertebral foramen 188, between a ventrally-located ventral body 196 and a dorsally-located transverse process 198 and spinous process 197. Arrows V and D identify the ventral and dorsal directions, respectively. The spinal cord 191 is located within the dura mater 199, which also surrounds portions of the nerves exiting the spinal cord 191, including the ventral roots 192, dorsal roots 193 and dorsal root ganglia 194. In one embodiment, a single first signal delivery device 110a is positioned within the vertebral foramen 188, at or approximately at the spinal cord midline 189. In another embodiment, two second signal delivery devices 11Ob are positioned just off the spinal cord midline 189 (e.g., about 1 mm. offset) in opposing lateral directions so that the two signal delivery devices 1 10b are spaced apart from each other by about 2 mm. In still further embodiments, a single signal delivery device or pairs of signal delivery devices can be positioned at other locations, e.g., at the dorsal root entry zone as shown by a third signal delivery device 11 Oc, or at the dorsal root ganglia 194, as shown by a fourth signal delivery device 11Od. [0035] In any of the foregoing embodiments, it is important that the signal delivery device 110 and, in particular, the electrical contacts of the device, be placed at a target location that is expected (e.g., by a practitioner) to produce efficacious results in the patient when the device 110 is activated. The following disclosure describes techniques and systems for securing signal delivery devices 110 at target modulation sites, and/or otherwise securing connections between elements of the systems, and/or between system elements and the patient's body. Particular embodiments are described below in the context of securing a lead relative to the patient's tissue. In other embodiments, similar or identical arrangements are used to secure a lead or lead -7- WO 2013/112920 PCT/US2013/023275 extension to an implanted pulse generator or external modulation device, to secure a lead to a lead extension, to secure a lead or lead extension to an operating room cable (e.g., at the connector 122 described above), and/or to perform other securement functions, e.g., in the context of neural modulation. [0036] Figure 2A is an isometric illustration of a lead anchor 250 having features in accordance with embodiments of the disclosure. The lead anchor 250 can releasably attach a lead (e.g., the lead 111 illustrated in Figure 1A) or other signal delivery element to tissue adjacent to or in the epidural space around the spinal cord. The anchor 250 includes an anchor sleeve 252 having a distal end 254, a proximal end 256, an exterior surface 253, and a longitudinally-extending lumen 258. The lumen 258 has an interior surface 251 extending from a distal end opening 261 at the distal end 254 to a proximal end opening 263 at the proximal end 256. The lead 111 can be inserted into the lumen 258 so as to extend through the anchor sleeve 252 from the proximal end opening 263 to the distal end opening 261. As will be described in further detail below with reference to Figure 2B, the anchor 250 further includes a lead securement region 262 at which a lead securement device 260 is located. The lead securement device 260 can engage and secure the lead 111 when the lead 111 is positioned in the lumen 258. [0037] The lead anchor 250 can include an aperture 266 extending inwardly from the exterior surface 253. The aperture 266 can include a first portion 266a that extends to the interior surface 251 of the anchor sleeve 252, e.g., transverse to the major axis of the lumen 258. The aperture 266 can also include a second portion 266b, aligned with the first portion 266a and extending into the lead securement device 260. Accordingly, and as will be discussed in further detail below with reference to Figure 2B, the aperture 266 can provide a practitioner with access to the lead securement device 260. In certain embodiments, such as those described below with reference to Figures 3 and 4, the lead anchor 250 can include more than one aperture 266 extending through the anchor sleeve 252. In some embodiments, the anchor sleeve 252 is made of plastic, metal, silicone, another biocompatible material, and/or a combination of materials. In certain embodiments, the anchor sleeve 252 can include a radiopaque marker (e.g., an embedded platinum or metallic component) to aid the practitioner in positioning the anchor sleeve 252. In the illustrated embodiment, the -8- WO 2013/112920 PCT/US2013/023275 anchor sleeve 252 is generally tapered toward both the distal and proximal ends 254, 256. In further embodiments, the anchor sleeve 252 is not tapered, or only one of the distal or proximal ends 254, 256 is tapered, or the anchor sleeve 252 can widen toward the distal and/or proximal ends 254, 256. [0038] One or more tissue-securing features 257 (identified individually as first and second tissue-securing features 257a, 257b) can secure the anchor 250 to the patient. In the illustrated embodiment, the tissue-securing features 257a, 257b extend laterally from the anchor sleeve 252 and include eyelets 259 through which the practitioner can loop a suturing thread (not shown) to affix the anchor 250 to a patient's tissue. In various embodiments, the anchor 250 can have more or fewer eyelets 259 or other fastening features, and/or the tissue-securing features 257a, 257b can be located at additional or other positions on the anchor sleeve 252. [0039] In certain embodiments, at least a portion of an external surface 212 of the lead 111, or the interior surface 251 of the anchor sleeve 252 can have features (e.g., roughness features), coatings, and/or other elements to increase a coefficient of friction between the lead 111 and the interior surface 251 of the anchor sleeve 252. In some embodiments, for example, the lead 111 and/or the interior surface 251 of the anchor sleeve 252 can include bulges or other friction features, and/or can comprise a high friction material (e.g., rubber), and/or can be laser or chemically etched to increase friction. Furthermore, in certain embodiments, the lead 111 can include barbs, extensions, protrusions and/or other features that can engage the interior surface 251 of the anchor sleeve 252, e.g., to releaseably affix the lead within the anchor sleeve 252. [0040] Figure 2B illustrates a representative lead securement device 260 that can be housed in the sleeve 252 described above. Depending upon the particular embodiments, the securement device 260 may be used to secure a lead or other signal delivery element in a pulse generator, a lead extension component, or a component that may releasably couple a lead or other signal delivery element to an external stimulator. In this embodiment, the lead securement device 260 is configured to clamp or otherwise secure the lead 111 in position. The securement device 260 can accordingly include a restriction member 263 and an actuator, e.g., a set screw 264, configured to actuate the restriction member 263. For purposes of illustration, the -9- WO 2013/112920 PCT/US2013/023275 actuator is shown as a set screw in many of the Figures. In other embodiments, the actuator can have other suitable threaded or unthreaded configurations. The securement device 260 includes a device lumen 258a that receives the restriction member 263 and is aligned to be co-axial with the lumen 258 in the anchor sleeve 252 (Figure 2A). The restriction member 263 can be accessible via the second portion 266b of the aperture 266. The restriction member 263 can comprise a medical grade metal or alloy thereof (e.g., stainless steel, nickel titanium, or nickel-cobalt-molybdenum alloys such as MP35N, etc.), and/or another biocompatible material. In the illustrated embodiment, the restriction member 263 takes the form of a sheet and has a C-shape in cross-section when deployed to extend around only a portion of the circumference of the interior surface 251 of the device lumen 258a as shown in Figure 2B. The restriction member 263 can accordingly form a radially compressible collet within the device lumen 258a and around the lead 111. The set screw 264 can be sized to threadably engage with threads in the second portion 266b of the aperture 266 to engage the restriction member 263. Accordingly, the practitioner can tighten the set screw 264 against the restriction member 262, which in turn clamps against the lead 111. [0041] Referring to Figures 2A and 2B together, the practitioner in use can introduce the lead 111 into the patient's body with a stylet, introducer, or other suitable device. The practitioner then threads the lead anchor 250 along the lead 111, and secures the anchor 250 to the lead 111 by advancing the set screw 264 (located in the aperture 266) radially inward. As the set screw 264 advances and engages with the restriction member 263, the restriction member 263 exerts a radial clamping force on the lead 111. The practitioner can vary the degree to which the restriction member 263 compresses the lead 111. In some embodiments, the set screw 264 can be advanced into the aperture 266 by a torque wrench that clicks upon applying a preset level of torque. The practitioner can then secure the anchor 250 in place by suturing the anchor 250 to the tissue, using the eyelets 259 in the tissue-securing features 257a, 257b. [0042] If the practitioner wishes to reposition the lead 111 (e.g., to adjust the positions of the modulation contacts for improved treatment), the practitioner can release the connection between the anchor 250 and the lead 111 without having to -10- WO 2013/112920 PCT/US2013/023275 detach the anchor 250 from the patient. For example, the practitioner can turn the set screw 264 in the reverse direction to provide less compressive force on the restriction member 263. In other embodiments, a twisting or unlocking motion can disengage the restriction member 263 and release the compressive force on the lead 111. The restriction member 263 can be at least partially restored to its original cross-sectional shape after the set screw 264 is removed or loosened. Once the restriction member 263 has been loosened, the practitioner can reposition the lead 111 relative to the anchor 250. Once the lead 111 has been repositioned, the practitioner can tighten the set screw 264 in the manner described above, and can then apply an electrical modulation therapy to the patient. [0043] Figure 2C is a partially schematic, isometric view of a restriction member 263 configured in accordance with a representative embodiment. The restriction member 263 can include an axially-extending gap 264a that allows the restriction member 263 to tighten around the lead, as discussed above. The restriction member 263 can also include one or more slots or cut-outs 264b that can be formed to reduce the volume/weight of the restriction member 263 and/or control the flexibility of the restriction member 263. [0044] Figures 3 and 4 are isometric illustrations of lead anchors configured in accordance with further embodiments of the present technology. Referring first to Figure 3, a representative lead anchor 350 has several features generally similar to those described above with reference to Figures 2A and 2B. The lead anchor 350 further includes a plurality of apertures, identified individually as apertures 366a-366c. In the illustrated embodiment, the apertures 366a-366c are longitudinally aligned. The multiple apertures 366a-366c allow a practitioner to clamp a lead at one or more of several locations by applying a compressive force via one or more of a plurality of actuators (e.g., multiple set screws 264 of the type shown in Figure 2B). Using multiple screws 264 can provide additional stability for the lead, particularly for long leads, and/or can provide multiple points by which to access and secure the lead. This arrangement can have particular benefits if the lead anchor 350 is positioned in the patient in such a way that a single aperture would be obscured or otherwise inaccessible. -11- WO 2013/112920 PCT/US2013/023275 [0045] Figure 4 illustrates a lead anchor 450 having features generally similar to those described above with reference to Figures 2A-3. The lead anchor 450 further includes a plurality of apertures, identified individually as apertures 466a-466c, that are circumferentially offset from one another (e.g., in a spiral or helical arrangement). In addition to the benefits described above, the offset apertures 466a-466c can provide a practitioner with additional flexibility in securing the lead. For example, if the physician's access to one of the apertures 466a-466c is obstructed by the patient's tissue, the practitioner has multiple other apertures which may be more accessible for advancing a set screw and securing the lead. In further embodiments, the lead anchor 450 can include more or fewer apertures 466a-466c and the apertures can be aligned more or less along a longitudinal line or in another pattern or arrangement. [0046] Certain embodiments of the technology described above can additionally or alternately include other features or methods that further improve lead securement. For example, in some embodiments, the restriction member can be formed from a shape-memory material so as to transform between a first configuration (in which a lead is freely positionable relative to an anchor sleeve) and a second configuration (in which the lead is removably and releasably secured). A representative shape memory material is nickel titanium. The restriction member can be activated (e.g., deformed) by applying heat, electricity, mechanical force, or other energy forms to transform between the first and second configuration. In certain embodiments, the shape-memory transition can occur after the energy is imparted via a tool. In other embodiments, the transition can occur when the anchor is transitioned from ambient conditions to the conditions in the human body (e.g., when body heat is applied to the shape-memory material). The use of shape-memory materials can be in addition to, or in lieu of, other locking mechanisms described herein (e.g., the set screw 264 illustrated in Figure 2B). [0047] In further embodiments, the lead securement device can have a clamshell configuration. For example, the lead securement device can include an upper and lower component or a single component that opens and closes like a book or clamshell. The lead securement device can accommodate one or more leads in an interior lumen while in an open configuration and can apply a compressive force to the lead(s) upon closing. The upper and lower components can be securably closed via snaps or other fastening mechanisms. Representative embodiments are described in -12- WO 2013/112920 PCT/US2013/023275 further detail below with reference to Figures 9A-10D. In certain embodiments, the lumen can include barriers, such as posts or pivot points, that force the lead to take a non-linear path within the anchor sleeve. The tortuous path that results can inhibit or eliminate lead migration relative to the anchor. Similarly, in certain embodiments, a pre-shaped, curved lead body can be straightened for implanting with a stylet or introducer. When the stylet or introducer is removed, the lead can return to its original curved shape, which provides for improved anchor fixation. [0048] In certain embodiments, chemical solutions can be applied to a lead to provide or improve lead fixation. For example, in one embodiment, a lead anchor can include a foam or other expansive material. The expansive material, when mixed with saline or other liquid, can expand and exert a compressive force on the lead, thereby holding the lead in place. In further embodiments, adhesives, such as UV quickset adhesives, can be applied to fix the lead in place. The adhesives can be dissolved, etched or otherwise chemically altered to release the lead. In a particular embodiment, the anchor can include multiple chambers. A first chamber can contain one component of a two-part adhesive (e.g., an epoxy) positioned along a lead/anchor interface. A second chamber separated by a membrane from the first chamber can include a second component of the two-part adhesive. In certain embodiments, the chambers are coaxial. When the membrane between the chambers is broken, the adhesives can intermix, triggering the curing process of the adhesive and thereby affixing the lead in place. [0049] Figures 5A and 5B illustrate a lead securement device 560 having a press member 564 configured in accordance with another aspect of the presently disclosed technology. For purposes of illustration, the securement device 560 in Figures 5A and 5B is shown without an anchor sleeve. In at least some embodiments, the securement device 560 and/or other anchor devices described below can be installed in an anchor sleeve, e.g., generally similar to the anchor sleeve 253 shown in Figure 2A. In particular embodiments, the securement device 560 may be used to secure a lead or other signal delivery element in a pulse generator, a lead extension component, or a component that may releasably couple a lead or other signal delivery element to an external stimulator. Beginning with Figure 5A, the lead securement device 560 includes a body 561, having a lead opening 565 positioned to receive a lead 111. The -13- WO 2013/112920 PCT/US2013/023275 press member 564 is positioned within the body so as to move toward the lead 111 (e.g., to clamp the lead 111 in a secured position) and away from the lead 111 (e.g., to release the lead 111). The lead securement device 560 accordingly includes an actuator 562 (e.g., a set screw or plunger) that drives the press member 564 toward and away from the lead 111. The actuator 562 can include a hex key aperture 563 or other feature that allows the practitioner to rotate the actuator 562 with a hex key or other tool. The lead securement device 560 can be positioned within an anchor sleeve in a manner generally similar to that described in further detail below with reference to Figure 6D. [0050] Figure 5B is a partially schematic, cross-sectional illustration of an embodiment of the lead securement device 560 shown in Figure 5A. As shown in Figure 5B, the press member 564 has an open interior with engagement features such as internal threads 566, and the actuator 562 has corresponding engagement features such as external threads 567 that mate with the internal threads 566. The actuator 562 can include a circumferentially-extending recess 568 that receives a retention element 569 (e.g., a pin) carried by the body 561. Accordingly, the actuator 562 remains captured within the body 561 so as to rotate with little or no axial motion. As it rotates, the actuator 562 drives the press body 564 toward and away from the lead opening 565, depending upon which direction the actuator 562 is rotated. The engagement features 566 and 567 may be optionally fully or partially coated with a material and/or otherwise treated to preferentially increase or control the friction therebetween for more accurate control of lead securement in operation. In some embodiments, such a coating and/or treatment may also be used on the surfaces of the press member 564 and/or body 561 that come in contact with the lead 111 so to limit or eliminate the lead's contact with metal. As shown in Figure 5B, the actuator 562 has been activated to drive the press body 564 down to compress the lead 111 against the interior surface(s) of the lead cavity 565. The actuator 562 can be driven in the opposite direction to release the lead 111. [0051] Figures 6A and 6B illustrate a lead securement device 660 that includes a press member 664 having features distinct from those described above with reference to Figures 5A and 5B. Such a device 660 may in particular embodiments be used to secure a lead or other signal delivery element in a pulse generator, a lead extension -14- WO 2013/112920 PCT/US2013/023275 component, or a component that may releasably couple a lead or other signal delivery element to an external stimulator. Referring first to Figure 6A, the lead securement device 660 includes a body 661, a lead opening 665, a press member 664 positioned proximate to the lead opening 665, and an actuator 662 positioned to drive the press member 664 toward and away from the lead opening 665, as indicated by arrow T. In addition, the lead securement device 660 can include external features 666 positioned at the body 661. The external features 666 can include ridges, grooves, troughs, and/or other roughness elements that aid in securing the lead securement device 660 to a corresponding sleeve, as will be described further below with reference to Figure 6D. The surfaces of the press member 664 and/or the lead opening 665 may be partially or completely coated with a plastic or polymer, and/or may otherwise be treated to increase friction with the lead and/or limit contact between the lead and metal components of the securement device 660. [0052] Referring next to Figure 6B, the actuator 662 is captured axially between a lip 670 extending inwardly from the body 661, and a washer or cap 671 (e.g., a retention element) positioned over the actuator 662. Accordingly, as the actuator 662 is rotated, it drives the press member 664 toward and away from the lead opening 665, as indicated by arrow T. [0053] Figure 6C is a partially schematic, cross-sectional illustration of an embodiment of the lead securement device 660 housed in a lead anchor 650 that includes an anchor sleeve 652. The lead anchor 650 also includes a lumen 658 positioned to receive a lead in a manner generally similar to that described above with reference to Figure 2A. The external features 666 described above with reference to Figure 6B extend inwardly and outwardly from the plane of Figure 6C and accordingly are not visible in Figure 6C. Figure 6D, which illustrates a cross-section of the lead anchor 650, taken substantially along lines 6D-6D of Figure 6C, illustrates the external features 666 engaged with the material forming the sleeve 652. [0054] Figure 6E is a partially schematic, isometric illustration of the lead anchor 650. The lead securement device 660 (Figure 6D) is not visible, but is contained within the sleeve 652. An aperture 673 extends through the sleeve 652 to allow access to the actuator 662 (Figure 6C) of the lead securement device 660. The lead anchor 650 can -15- WO 2013/112920 PCT/US2013/023275 further include tissue securing features 657a, 657b for securing the lead anchor 650 to the patient's tissue in a manner generally similar to that described above. [0055] Figure 7A is a partially schematic, isometric illustration of a lead securement device 760 having a collet arrangement in accordance with another embodiment of the present technology. The lead securement device 760 can include a body 761 that extends at least partially into an actuator 762. The actuator 762 and the body 761 have lead openings 765, e.g., coaxial openings (one of which is visible in Figure 7A), to receive a lead. The actuator 762 is rotatable about a rotation axis A as indicated by arrow R, e.g. by grasping flats 759 with the practitioner's fingers or a tool, to tighten the body 761 against a lead placed within the lead opening 765, as is described further below with reference to Figures 7B-7C. [0056] Figure 7B is a partially schematic, isometric illustration of the body 761 shown in Figure 7A, with the actuator 762 removed. The body 761 includes multiple collet fingers 763 (four are shown in Figure 7B) that can be formed from metal, its alloys, plastic or another flexible, resilient material suitable for clamping against a lead. [0057] Figure 7C is a partially schematic, cross-sectional illustration of the lead securement device 760 shown in Figure 7A. The body 761 includes engagement features such as external or male threads 767 (shown schematically) that mesh with corresponding engagement features such as internal or female threads 766 (shown schematically) carried by the actuator 762. The collet fingers 763 bear against an internal surface of the actuator 762. In a particular embodiment, an external angle 768a of the collet fingers 763 is approximately the same as an internal angle 769a of the actuator 762. In other embodiments (e.g., as described below with reference to Figure 7D) these angles can be different. In any of these embodiments, as the actuator 762 is threaded along the body 761, the internal surface of the actuator 762 clamps the collet fingers 763 against a lead 111 positioned in the lead opening 765. [0058] Figure 7D is a partially schematic, cross-sectional illustration of a body 761a and an actuator 762a having different mating angles. For example, the body 761a can carry collet fingers 763a having an external angle 768b that is different than (e.g., greater than) an internal angle 769b of the actuator 762a. Accordingly, the actuator 762a can more positively engage the collet fingers 763a and clamp the fingers 763a against the lead 111. -16- WO 2013/112920 PCT/US2013/023275 [0059] Figure 8A is a partially schematic, isometric illustration of an anchor 850 that includes a lead securement device 860 having a collet arrangement in accordance with another embodiment of the present technology. In one aspect of this embodiment, the lead securement device 860 includes a body 861 having spaced apart, flexible, resilient collet fingers 863, and an actuator 872 that fits over the collet fingers 863 and is threadably attached to the body 861. The lead securement device 860 can be partially housed in an anchor sleeve 852 that includes two separable anchor sleeve components 852a, 852b. [0060] In operation, the components of the anchor 850 (e.g., the anchor sleeves 852a, 852b, the body 861 and the actuator 872) are threaded over the lead 111 in the order shown in Figure 8A. As shown in Figure 8B, the actuator 872 is then threaded onto the body 861 to tighten the collet fingers 863 (Figure 8A) radially inwardly onto the lead 111. At this point, the lead securement device 860 is secured to the lead 111. In Figure 8C, the anchor sleeve portions 852a, 852b are slid over the ends of the lead securement device 860. The anchor sleeve portions 852a, 852b include eyelets 859 that the practitioner then sutures to the patient to secure the anchor 850 in position. If the lead 111 is to be repositioned, the foregoing steps can be reversed to loosen the lead anchor 850. Then the lead 111 is moved relative to the anchor 850, and the forgoing steps are repeated to re-secure the lead anchor 850 to the lead 111. [0061] Figure 9A is a partially schematic, isometric illustration of a lead anchor 950 having a "push and lock" configuration in accordance with yet another embodiment of the present technology. In one aspect of this embodiment, the lead anchor 950 includes a securement device 960 that in turn includes a press member 964 received in a receptacle 970. The press member 964 can include a cap 965 and locking ribs 968 that engage with corresponding features in the receptacle 970. The lead anchor 950 can further include a suture member 966 having eyelets 959, that is removably received in a suture member slot 967 of the press member 964. The press member 964 is in turn received in the receptacle 970, with the suture member 966 received in a suture member recess 971 of the receptacle 970. [0062] To begin the securing process, the lead 111 is positioned in the receptacle 970. The suture member 966 is then inserted into the suture member slot 967, as indicated by arrow I. Referring now to Figure 9B, the press member 964 (with the -17- WO 2013/112920 PCT/US2013/023275 suture member 966 is now positioned in the suture member slot 967, shown in Figure 9A) is positioned over the receptacle 970. The press member 964 is then lowered and pressed into the receptacle 970, as indicated by arrows P, with the suture member 966 received in the suture member receptacles 971. [0063] In Figure 9C, the press member 964 has been fully inserted into the receptacle 970. Accordingly, the press member 964 presses the lead 111 against an upwardly facing surface of the receptacle 970 (not visible in Figure 9C). In addition, the cap 965 is releasably locked in the receptacle 970, and presses the suture member 966 into the suture member recesses 971 (Figure 9B). Accordingly, both the suture member 966 and the lead 111 are secured relative to the receptacle 970. [0064] Figure 9D is a partially schematic, cross-sectional illustration of the lead anchor 950, taken substantially along line 9D-9D of Figure 9C. Figure 9E is an enlarged view of a portion of the lead anchor 950 shown in Figure 9D. Referring to Figures 9D and 9E together, the locking ribs 968 carried by the press member 964 are received in the receptacle 970 and interlock with corresponding features 969. The interlocking action of these features prevents or at least restricts the press member 964 from moving out of the receptacle 970, unless it is actively pried out by a practitioner, e.g., for repositioning the lead anchor 950 relative to the lead 111. [0065] Figures 10A-10D illustrate a lead anchor 1050 having a "clamshell" arrangement in accordance with another embodiment of the present technology. Figure 1 OA is a partially exploded view of a securement device 1060 of the lead anchor 1050, having a first portion 1061a rotatably coupled to a second portion 1061b with a hinge pin 1062. The first and second portions 1061a, 1061b can include an interlock 1063 that in turn includes a first element 1063a (e.g., a rib) carried by the first portion 1061a, and a second element 1063b (e.g., a lip) carried by the second portion 1061b. [0066] Figure 10B is a reverse view of the securement device 1060 shown in Figure 1 OA, positioned around a lead 111. In addition, first and second portions 1052a, 1052b of a sleeve 1052 have been threaded onto the lead 111 on opposite sides of the lead securement device 1060. The interlock 1063 described above with reference to Figure 1OA can further include a finger tab 1063c that allows a practitioner to open the securement device 1060, should it become desirable to reposition the securement device 1060 relative to the lead 111. -18- WO 2013/112920 PCT/US2013/023275 [0067] Referring next to Figure 10C, the first and second portions 1061a, 1061b have been releasably clamped around the lead 111 to secure the lead securement device 1060 in position. Then, as shown in a reverse view in Figure 1OD, the first and second portions 1052a, 1052b of the sleeve 1052 are slid over the ends of the lead securement device 1060 to releasably attach the sleeve 1052 to the lead securement device 1060. The practitioner can then suture the anchor 1050 using suture holes 1059 carried by the sleeve 1052. [0068] Figures 11A-11E illustrate still another lead anchor 1150 having a guided piston arrangement for securing the lead anchor to the lead 111. Beginning with Figure 11A, the lead anchor 1150 includes a securement device 1160 that in turn includes a body 1161 in which a piston 1162 is received. The piston carries a guide pin 1163 that is received in a spiral slot 1164. In preparation for securing the lead anchor 1150 to the lead 111, a sleeve 1152 (including a first portion 1152a and a second portion 1152b) are threaded along the lead 111 along with the lead securement device 1160, in the order shown in Figure 11A. [0069] Figure 11 B is an enlarged illustration of the lead securement device 1160, illustrating the piston 1162 in an unlocked position. In this position, the guide pin 1163 is located at one end of the guide slot 1164. The opposing end of the guide slot 1164 includes a detent 1165 that receives the guide pin 1163 and restricts it from further movement relative to the body 1161, unless directly acted upon by a user (e.g., a practitioner). To place the lead securement device 1160 in the locked position, the practitioner rotates the piston 1162 clockwise, as indicated by arrow R. [0070] Referring next to Figure 11C, the lead securement device 1160 has been placed in the locked position, with the piston 1162 advanced inwardly into the body 1161, and with the guide pin 1163 received in the detent 1165 at the end of the guide slot 1164. In Figure 11D, the first and second portions 1152a, 1152b have been slid over the ends of the lead securement device 1160 to complete the process of securing the securement device 1160 to the lead 111. The practitioner can then suture the sleeve 1152 to the patient via suture openings 1159. [0071] Figure 11 E is a partially schematic, cross-sectional illustration of the lead anchor and lead 111 in the secured position described above with reference to Figure 11D. As shown in Figure 11E, the piston 1163 bears against a resilient material 1167, -19- WO 2013/112920 PCT/US2013/023275 for example, an O-ring. The body 1161 includes a tapered (e.g., conical) bearing surface 1166 against which the resilient material 1167 is located. As the piston 1163 is moved from the unlocked position (Figure 11 B) to the locked position (Figure 11C), the piston 1163 drives toward the bearing surface 1166, forcing the resilient material 1167 radially inwardly and to the left as shown in Figure 11 E. Accordingly the resilient material 1167 bears radially inwardly against the lead 111, thus securing it in position relative to the lead securement device 1160. If it becomes desirable to release the lead securement device 1160 from the lead 111, the steps described above with reference to Figures 11 A-11 D are reversed, the lead 111 is then repositioned relative to the lead securement device 1160, and the foregoing steps are then repeated. [0072] The embodiments described above offer several advantages over traditional systems and can inhibit lead migration to improve treatment outcomes. Traditionally, lead migration has been the single most common technical complication associated with spinal cord stimulation, with reported rates as high as 13.2%. (Cameron, T., Safety and Efficacy of Spinal Cord Stimulation for the Treatment of Chronic Pain: A 20 Year Literature Review, J. Neurosurgery: 100:254-267 (March 2004).) The systems disclosed herein provide securable yet reversible arrangements for attaching the lead to the lead anchor, and the lead anchor to the patient. The practitioner can easily verify when the lead is secured by the lead anchor. For example, in embodiments for which a torque wrench is used to advance a set screw, a practitioner can be assured of proper clamping by an auditory or palpable indication (e.g., a "click") that the set screw has been advanced a given gradation. This can remove much of variability and guesswork involved with anchoring leads. [0073] An additional advantage is the ability to reposition a lead relative to the lead anchor. By repositioning rather than re-implanting the lead, the practitioner can reduce procedure time and improve placement accuracy as compared to traditional systems. Procedure time can be further reduced in embodiments for which an anchor secures more than a single lead. By having multiple leads within an anchor, the practitioner can additionally mitigate relative motion between the implanted leads. For example, embodiments of the "clamshell" arrangement and/or the "push and lock" arrangement described above with reference to Figures 10A-10D can accommodate two (or more) leads side by side, e.g., each in an individual, longitudinal extending groove. -20- WO 2013/112920 PCT/US2013/023275 [0074] From the foregoing, it will be appreciated that specific embodiments of the technology have been described herein for purposes of illustration, but that various modifications may be made without deviating from the technology. For example, in some embodiments the restriction member can have a fully circular cross-sectional shape but can readily compress and re-expand in a radial direction. In other embodiments, the anchor sleeve can include apertures arranged in patterns other than those specifically described above. Certain aspects of the technology described in the context of particular embodiments may be combined or eliminated in other embodiments. For example, in some embodiments the anchor may not have a set screw and the lead can be secured to the anchor by other mechanisms. Further, while advantages associated with certain embodiments have been described in the context of those embodiments, other embodiments may also exhibit such advantages and not all embodiments need necessarily exhibit such advantages to fall within the scope of the present technology. Accordingly, the present disclosure and associated technology can encompass other embodiments not expressly described or shown herein. -21-
    权利要求:
    Claims (20)
    [1] 1. A lead anchor, comprising: an implantable anchor sleeve having a lumen extending therethrough, the lumen being positioned to removably receive an implantable lead; a securement device within the anchor sleeve, the securement device including a lead opening aligned with and positioned along the lumen of the anchor sleeve to removably receive the implantable lead; a press member positioned within the securement device, the press member being slideable within the securement device toward the lead opening to clamp the implantable lead, and away from the lead opening to release the implantable lead; a rotatable actuator threadably engaged with the press member to move the press member toward the lead opening when rotated in a first direction, and move the press member away from the lead opening when rotated in a second direction opposite the first direction; and a retention element carried by the securement device and positioned to at least restrict axial motion of the actuator toward and away from the lead opening.
    [2] 2. The lead anchor of claim 1, further comprising the implantable lead.
    [3] 3. The lead anchor of claim 1 wherein the actuator includes a recess, and wherein the retention element projects inwardly from the securement device and into the recess.
    [4] 4. The lead anchor of claim 1 wherein the retention element includes a cap positioned over the actuator, with the actuator positioned between the cap and the lead opening. -22- WO 2013/112920 PCT/US2013/023275
    [5] 5. A lead anchor, comprising: a securement device having a lead opening positioned to removably receive an implantable lead; and an actuator carried by the securement device to move an element of, or carried by, the securement device toward and away from the lead opening to releasably secure the implantable lead in the lead opening.
    [6] 6. The lead anchor of claim 5, further comprising a press member positioned within the securement device and operably engaged with the actuator, the press member being movable within the securement device toward the lead opening to clamp the implantable lead, and away from the lead opening to release the implantable lead.
    [7] 7. The lead anchor of claim 6 wherein the press member has a generally rectangular corss-sectional shape.
    [8] 8. The lead anchor of claim 5, further comprising a retention element carried by the securement device and positioned to at least restrict motion of the actuator toward and away from the lead opening.
    [9] 9. The lead anchor of claim 5, further comprising a sleeve positioned around at least a portion of the securement device, the sleeve having one or more suture eyelets positioned to receive suture thread to secure the sleeve to patient tissue.
    [10] 10. The lead anchor of claim 5, further comprising a flexible actuator sleeve at least partially surrounding the securement device, and wherein the securement device includes external elements positioned to restrict relative motion between the securement device and the sleeve.
    [11] 11. The lead anchor of claim 5 wherein in the securement device includes a body having one or more collet fingers positioned around the lead opening, and wherein the actuator is movably engaged with the body to move the collet fingers radially inwardly to secure the lead, and radially outwardly to release the lead. -23- WO 2013/112920 PCT/US2013/023275
    [12] 12. The lead anchor of claim 5 wherein the securement device includes a flexible, resilient retention member positioned at least partially around the lead opening, and wherein the actuator is engaged with the retention member and is movable to flex the retention member toward the lead opening to secure the lead.
    [13] 13. The lead anchor of claim 12 wherein the restriction member comprises sheet metal.
    [14] 14. The lead anchor of claim 12, wherein the restriction member has a C shaped cross-section.
    [15] 15. A method for securing an implantable lead in a patient, comprising: positioning the lead in the patient; advancing a lead anchor along the lead; securing the lead anchor to patient tissue; and releasably securing the lead anchor to the lead by activating an actuator, causing the actuator to move an element into contact with the lead.
    [16] 16. The method of claim 15 wherein activating the actuator includes rotating the actuator.
    [17] 17. The method of claim 16 wherein wherein causing the actuator to move an element includes causing the actuator to move a press member along a generally linear path into contact with the lead.
    [18] 18. The method of claim 17, further comprising: restricting or preventing axial motion of the actuator; and restricting or preventing rotational motion of the press member.
    [19] 19. The method of claim 16 wherein causing the actuator to move an element includes causing the actuator to move collet fingers radially inwardly into contact with the lead. -24- WO 2013/112920 PCT/US2013/023275
    [20] 20. The method of claim 15, further comprising suturing the lead anchor to the patient's tissue. -25-
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    法律状态:
    2016-11-24| FGA| Letters patent sealed or granted (standard patent)|
    优先权:
    申请号 | 申请日 | 专利标题
    US201261590769P| true| 2012-01-25|2012-01-25||
    US61/590,769||2012-01-25||
    PCT/US2013/023275|WO2013112920A1|2012-01-25|2013-01-25|Lead anchors and associated systems and methods|
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