• 专利附录
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    • 专利摘要:
    A sensor band (1), which is attached along the aorta for about 30 cm, carries two skin electrodes (2) and (3) or (5) and (6) at the top and bottom, as well as a further middle one (4). By means of two end electrodes (2) and (6) a high-frequency electric field is built up in the fuselage. Between two end electrodes (3) and (5) opposite to the center electrode (4), two voltage signals are derived. They are broken down into their respective respiratory and cardiac components. From the respiratory components temporal changes of the thoracic resp. Abdominal respiration are concluded, as well as possible thoracic / abdominal paradox, from the cardiac to the heart rate and the blood pressure.
    公开号:AT518929A1
    申请号:T373/2016
    申请日:2016-08-12
    公开日:2018-02-15
    发明作者:Dr Pfuetzner Helmut；Karl Futschik Dr
    申请人:Dr Pfuetzner Helmut；
    IPC主号:
    专利说明:

    An approximately 30 cm long sensor tape (1) attached along the aorta carries two skin electrodes (2) and (3) or (5) and (6) at the upper and lower ends, as well as a further middle one (4). A high frequency electric field is built up in the fuselage by means of two end electrodes (2) and (6). Two voltage signals are derived between two end electrodes (3) and (5) opposite the center electrode (4). They are broken down into their respiratory and cardiac components. The respiratory components are used to infer temporal changes in thoracic or abdominal breathing, as well as any thoracic / abdominal paradox, and in the cardiac to heart rate and blood pressure.
    1/7 • ·
    Sensor tape for multi-parametric cardiopulmonary diagnostics
    The invention relates to a device for detecting and classifying sleep apneas. Obstructive or central apneas are breathing interruptions lasting at least ten seconds, which can cause daytime tiredness but also reduced life expectancy. Full diagnostics are carried out by means of so-called polysomnography (PSG) using many sensors distributed over the body. There are also portable systems - such as in US4802485 or described - for use in which the number of sensors is greatly reduced. However, this also reduces the number of physiological parameters that can be evaluated. Simply designed systems have the advantage that they can be applied easily and have little impact on the patient's sleep quality. However, full medical recognition - especially from the American Academy of Sleep Medicine - usually fails due to the requirement to prove that in the case of a classification of a supposed obstructive apnea, no breathing air is actually taken in from outside. At the PSG, this control is carried out by a nasal breathing sensor. An alternative is the detection of reduced oxygen saturation using an oximeter. Both the breathing sensor and the oximeter represent a significant burden on the patient and, moreover, complicate the portate system.
    The aim of the present patent is a device that hardly poses a burden to the patient, is hardly to be beaten in terms of simplicity, but nevertheless provides sufficient physiological information for clear classification.
    According to the invention, this is achieved in that a sensor band (1) provided with five skin electrodes is arranged along the aorta, by means of two embossing electrodes (2) and (6) located at the ends, a high-frequency electric field is generated in the tissue of the thorax and by means of An upper and a lower voltage signal are derived from two lead electrodes (3) and (5) at the ends opposite a central lead electrode (4), which are fed to an electronic system for determining temporal changes in the activity and paradox of respiration as well as the heart rate and blood pressure ,
    The device is described in more detail below with reference to Fig.l. Schematically here is an approximately 30 cm long and 3 cm wide, e.g. Sensor band 1 made of skin-compatible plastic is indicated, which on the skin of the patient to be monitored e.g. is attached with leucoplast. It is placed by trained medical personnel, starting in the abdominal region of the navel up to the region of the left clavicle. It is offset to the left opposite the sternum so that it lies approximately over the axis of the aorta.
    On the skin side, five electrodes 2 to 6 are attached to the band, which e.g. are made of stainless steel like rivets or buttons. At the upper end of the band there is an embossing electrode 2 and a lead electrode 3, in the middle of the band a lead electrode 4 and at the lower end of the band a lead electrode 5 and a lead electrode 6 Connects electrodes 2 to 6 (possibly wirelessly) with an electronic system which has hardware and software components in the usual, known manner.
    By means of a high-frequency current source 7, a high-frequency electric flow field is generated in the tissue of the thorax via the impression electrodes 2 and 6. The frequency is of the order of 30 kHz, the total current below 1 mA. This prevents neuronal or thermal biological effects. On the other hand, it is ensured that the types of tissue relevant for signal generation, such as lung tissue and blood, differ significantly in their behavior. An upper, thoracic voltage signal is derived between electrodes 3 and 4, and a lower, abdominal signal u A between 4 and 5. The two high-frequency signals are fed to an electronic system via the connection part. In a well-known procedure, the signals are amplified and demodulated in conditioners 8 and 9. This creates the lowest-frequency physiological mixed signals. Without further processing, normal breathing is a signal with a dominant respiratory component St, r or s a , r, which is superimposed on a weaker cardiac component St, k or Sa, κ. The conditioners 8 and 9 perform a / 7 rough separation of the mixed signals into the four components by means of four, preferably digital filters, in a well-known procedure. As described in detail in the literature (in particular in: Medical Progress Through Technology 21, 17-28, 1995), the respiratory frequency f R usually remains below 0.7 Hz while the cardiac frequency / K is above 0.7 Hz. With this value as the upper limit frequency, two respiratory filters deliver the respiratory signals s t , r and s a , r as a rough, non-linear measure of lung activity. Two cardiac filters with 0.7 Hz as the lower limit frequency deliver the two cardiac signals s t , k and s a , k as non-linear measures of the blood release. Exact separations are not required for the purposes of classifying apneas.
    As diagnostically relevant physiological parameters, six quantities are printed out as a function of time t or are displayed on a screen in a well known manner. The important respiratory parameters are the output of the thoracic signal s T , R (t) and the abdominal signal s A , R (t). According to the invention, a phase detector 10 is provided to detect paradoxical breathing relevant to obstructive apneas. It determines the phase shifts that occur between s T , R and s A , R , which can be very large in obstructive apneas. The time course (p R (t) is output as a diagnostically very important parameter.
    For the experienced medical professional, cardiac parameters also contain diagnostically important information. As an essential parameter, the heart rate is output as a cardiac frequency / K (t) as a function of time. The determination is made by a frequency counter 11, in which the frequency is determined according to known methods, for example via a time difference determination of zero crossings of the signal st, k. As an option, the determination is also made from s a , k, that is, with full redundancy. It is advantageous for patients with a high BMI because the cardiac signals can be very weak.
    As a third cardiac parameter, a phase detector 12 determines temporal changes </> K (t) of the phase angle occurring between s A , «and s t , k. A determination is made by determining the time offset between the thoracic or abdominal cardiac signal, with zero crossings or maxima being evaluated according to known procedures. The reciprocal of ψ κ is a measure of the speed of the arterial pulse wave triggered by the blood release and thus a non-linear measure of changes in blood pressure associated with apneas.
    As an advantageous option, the sensor band 1 carries in its upper area a noise sensor 13 for registering snoring noises by evaluating its acoustic signal s A according to known methods.
    According to the procedure customary in analog monitoring systems, a recording or screen display of the time profiles of the physiological parameters takes place in a synchronous manner with one another. An evaluation regarding the classification of apneas is carried out manually by trained medical personnel or by means of specific algorithms. Here are some of the features summarized below:
    Normal breathing (NA) - It is characterized by high amplitudes of s t , r and s A , R. There is little or no evidence for OAs below.
    Central Apnea (ZA) - Both amplitudes of s T , R and s A , R go to zero.
    Obstructive Apnea (OA) - Both amplitudes of St, r and s A , R are significantly reduced. The classification, on the other hand, is secured by means of a clear respiratory phase shift (0 R »0) in the sense of paradox. Experienced physicians also use the blood pressure changes accompanying the apnea as a diagnostic aid based on the phase shift φκ and heart rate changes f «, and ultimately also the occurrence of obsuctive snoring noise based on St, a . In summary, the claim is made that the device offers the following advantages over other methods of apnea monitoring: (i) simplest sensor technology which hardly poses a burden to the patient, (ii) despite the simplicity, numerous physiological parameters which favor clear classifications, (iii ) In particular, demonstrating paradox for the critical clarification of obstructive apneas.
    3/7 ·· · · · ··· ·· «» ···· · · · ·· • ·· ♦ ··· ···· ·; · · · · Ο · · / '· · · · Ο ····· ·· · • · ·· · ·· · ··

    1) Device for the detection and classification of sleep apneas, characterized in that a sensor band (5) provided with five skin electrodes is arranged along the aorta, by means of two impression electrodes (2) and (6) located at the ends, a high-frequency electrical Field in the tissue of the thorax is generated and by means of two end electrodes (3) and (5) opposite an intermediate electrode (4) an upper and a lower voltage signal are derived, which are used by an electronic system to determine changes in activity and time Paradox of breathing, heart rate and blood pressure.
    2) Device according to claim 1, characterized in that the electronic system is used to deduce thoracic / abdominal paradox from phase shifts of the respiratory components of the upper and lower signals.
    3) Device according to claim 1, characterized in that by means of the electronic system from phase shifts of the cardiac components of the upper or lower signal is deduced from changes in blood pressure over time.
    4) Device according to claim 1, characterized in that the sensor band (1) is optionally provided in its upper region with a noise sensor (13).
    / 7th
    · " • ·· ♦ "· • · • * • · 9 • «· • ♦ • • • · · · • • ♦ · • · • • ··· ··· ···· ··· * · •• · Λ • «• ··• ·• ··
    I axis of the aorta
    Fig.l
    5.7
    Search report for A 373/2016 Austrian Patent Office
    Classification of the subject of the application according to IPC:A61B 5/053 (2006.01); A61B 5/08 (2006.01); A61B 5/00 (2006.01) Classification of the application according to CPC:A61B 5/0535 (2013.01); A61B 5/0809 (2013.01); Ά61Β 5/0826 (07/07/2015); Ά61Β 5/4818 (01/01/2013); A61B 5/1264 (2013.01) Researched test substance (classification):A61B Consulted online database:EPODOC, WPIAP, TXTnn This search report was compiled on claims 1-4 filed on September 12, 2016. Category*) Title of the publication:Country code, publication number, document type (applicant), publication date, text or figure if necessary Concerningclaim AAAA WO 9965393 Al (MALLINCKRODT INC) December 23, 1999 (December 23, 1999)Figure 1 and description of the figureWO 2004112606 Al (UNIV DUBLIN) December 29, 2004 (December 29, 2004)Figure 2 and description of the figure, claimsWO 2005094498 A2 (NONINVASIVE MEDICAL TECHNOLOGI)October 13, 2005 (October 13, 2005)Figure 1 and description of the figureWO 2004032738 Al (UNIV QUEENSLAND) April 22, 2004 (April 22, 2004)Figure 5 and description of the figure 1111 Date of completion of the research: ς t 1 1 examiner:01/30/2017 bene 1 of 1 KING Helga *> Categories of the listed documents: A publication that defines the general state of the art.X Publication of special importance: the application P document that is of importance (categories X or Y), but afterobject cannot be published as new or published on the priority date of the registration solely due to this publication,inventive activity can be considered based. E Document of particular importance (Category X) from whichY Publication of importance: the subject of the application may not result in an "older right" (earlier filing date, howevernovelty would be considered as based on inventive step, if the republished, protection is possible in AustriaMake publication with one or more other publications),is associated with this category and this connection for & publication which is a member of the same patent family.is obvious to a specialist.
    6.7
    权利要求:
    Claims (4)
    [1]
    1. A device for detecting and classifying sleep apneas, characterized in that a sensor strip (1) provided with five skin electrodes is arranged along the aorta, by means of two impression electrodes (2) and (6) located at the ends, a high-frequency electrical Field in the tissue of the thorax is generated and by means of two end electrodes (3) and (5) opposite an intermediate electrode (4) an upper and a lower voltage signal are derived, which are used by an electronic system to determine changes in activity and time Paradox of breathing, heart rate and blood pressure.
    [2]
    2. Device according to claim 1, characterized in that the electronic system contains a phase detector (10) for determining respiratory phase shifts between the thoracic signal component st, r and the abdominal signal component sa, r.
    [3]
    3. Device according to claim 1, characterized in that the electronic system contains a phase detector (11) for determining cardiac phase shifts between the thoracic signal component st, k and the abdominal signal component s a , k.
    [4]
    4. The device according to claim 1, characterized in that the sensor band (1) is optionally provided in its upper region with a noise sensor (13).
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    同族专利:
    公开号 | 公开日
    AT518929B1|2019-09-15|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    WO1999065393A1|1998-06-19|1999-12-23|Mallinckrodt, Inc.|Apnea detector with artifact rejection|
    WO2004032738A1|2002-10-09|2004-04-22|Queensland University Of Technology|High resolution bio-impedance device|
    WO2004112606A1|2003-06-24|2004-12-29|University College Dublin, National University Of Ireland, Dublin|Methods and apparatus for detecting sleep apnea using bioimpedance measurements|
    WO2005094498A2|2004-03-24|2005-10-13|Noninvasive Medical Technologies, Llc|Thoracic impedance monitor and electrode array and method of use|WO2019241362A1|2018-06-13|2019-12-19|General Electric Company|System and method for apnea detection|
    DE102018210051A1|2018-06-20|2019-12-24|Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.|Measuring device and method for determining at least one respiratory parameter|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    ATA373/2016A|AT518929B1|2016-08-12|2016-08-12|Sensor band for multi-parametric cardiopulmonary diagnosis|ATA373/2016A| AT518929B1|2016-08-12|2016-08-12|Sensor band for multi-parametric cardiopulmonary diagnosis|
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