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    • 专利摘要:
    This application relates to the measurement of intraocular lengths by double-beam Fourier short-coherence interferometry based on Fresnel zone-like space-time domain interferograms (RZI) of the Purkinje-Sanson reflexes. The measured object eye (1) is illuminated by a bundle of mutually parallel monochromatic monochromatic double beams (11) with different wavelengths in temporal sequence. The wavelength spectra of the space-time domain interferograms (51) are amplified by a photodetector array (70) with upstream image intensifier (BV) or a digital camera and registered by a photodetector array (70). Here, the viewing direction and position of the subject's eye are fixed with optical aids and controlled by means of acoustic and optical aids. A zoom optics (52) in the output beam of the ophthalmic interferometer allows - as inverse magnifying glass - by simply focusing the virtual Fresnel zone-like space-time domain interferograms (51) of the eye (1) from contrast-optimized positions on the photodetector An array (70) or on an upstream image intensifier (BV) (or digital camera) such that the position-dependent change in size of the RZI (51) is compensated by the scale change of this figure.
    公开号:AT518602A1
    申请号:T226/2016
    申请日:2016-05-03
    公开日:2017-11-15
    发明作者:Friedrich Dr Fercher Adolf
    申请人:Friedrich Dr Fercher Adolf；
    IPC主号:
    专利说明:

    PATENT APPLICATION
    Description:
    OPHTHALMOLOGICAL LENGTH MEASUREMENT USING DOUBLE JET SPACE TIME DOMAIN WAVELENGTH TUNING SHORT COHERENCE INTERFEROMETRY
    DESCRIPTION 1. TECHNICAL FIELD OF THE INVENTION Partial length ophthalmic length measurement is used in ophthalmology for sizing ablation parameters for refractive surgery and for sizing lens implants for refractive surgery and for cataract surgery. 2. PRIOR ART: Short-coherence interferometric length measurement in ophthalmology.
    Ophthalmic interferometry: The calculation of the refractive power of the lens to be implanted in cataract surgery or the refractive power change in refractive surgery is carried out by means of various biometric formulas on the basis of preoperative eye parameters such as eye length,
    Cornea thickness, corneal curvature, anterior chamber depth, lens power and lens thickness. For this purpose, the optical short-coherence (KK) interferometry is used today, because these, in the
    Contrary to the previously used acoustic measurement, non-contact and works by just over 1 order of magnitude more precise. Corresponding measuring instruments are offered commercially, for example, by the companies Carl Zeiss Meditec AG, Haag-Streit AG and NIDEK Co. and are described, for example, in the patents DE 103 23 920 A1 (Zeiss) and EP 1 946 039 B1 (Haag-Streit).
    Ophthalmologic interferogram: If one illuminates an eye from the side in front, one can observe the known Purkinje-Sanson images Pl, P2, P3 and P4 reasonably separated from one another, as shown in FIG. These are images of the light source illuminating the eye, created by reflection at the interfaces of the optics. Pl is formed by reflection on the cornea front surface, P2 by reflection on the corneal inner surface, P3 by reflection on the lens front surface, and P4 by reflection on the lens back surface. Together with the light reflected from the fundus of the eye, the reflections corresponding to the Purkinje-Sanson images form the basis for KK interferometry on the eye.
    If one illuminates the eye with temporally coherent light, one observes a speckle field in the space in front of the eye and interferences of the light rays of the Purkinje-Sanson reflexes in this embedded space-time domain: FIG. 1b shows in a snapshot this Fresnel zone-like one Space-time domain interferogram (RZI) embedded in the speckle structure; Figure lc shows an enlarged section thereof. This figure is the space domain interferogram of fundus reflex with corneal reflex. Because of the pulse-synchronous change in size of the globe, the local phase in this interferogram changes over time, the interference fringes pulsate in the radial direction synchronously with the cardiac pulse, hence: "space-time domain interferogram". Individual rays of this RZI form the rays of KK interferometry.
    The RZI depicted in Figure 1c is the most prominent among several similar RZI generated by the various Purkinje-Sanson reflexes. It is caused by interference between the wave reflected at the corneal anterior surface and that reflected from the fundus. The RZI is a section through a 3-dimensional interference phenomenon of the 2 waves mentioned, which consists of concentric, alternating bright (constructive interference) and dark (destructive interference) interference hollow cones, with increasing diameter along the optical axis of the eye.
    Partially congruent, occur - with regular anatomy of the eye - and RZI between fundus reflex and the reflexes of the cornea inner surface and the front surface of the eye lens.
    Double beam KK-interferometry: If one uses temporally short coherent light, the interference phenomena between the Purkinje-Sanson reflexes and the reflex disappear from the fundus. If, however, the eye is illuminated with a double beam of two internally temporally offset short-coherent light beams in an interferometer, the corresponding RZI can be made visible again, provided that the path difference AL of these two light beams corresponds within the coherence length lc to the optical length of the distance of the respective boundary surfaces in the eye. The same applies to the occasional interference based on single rays of KK interferometry.
    On this - easily measurable in the interferometer -Wegdifferenz
    , c = speed of light, At =
    Time difference of the double beam components are based both the KK interferometry and the WT interferometry used in this application. The determining factor for the resolving power of these measuring methods is the coherence length
    (1) with the central wavelength λ0 and the FWHM (Full Width at Half Maximum) bandwidth Δλ, the light rays - assuming a well-satisfied Gaussian light source in most of the light sources used here, for example superluminescent diodes.
    Spectrum. This is the dual beam time-domain KK measurement technique; it is based on the adaptation of the easily measurable interferometer-internal path difference to an optical path difference in the eye and is thus independent of movements of the eye as a whole relative to the meter. It delivers - without further
    Precautions - the structure of the eye at x = y = 0, that is on the visual axis along the measuring beam.
    Fresnel zone-like space-time domain Interferograms (RZI) can be used as real interferograms in front of the eye (in Figure 2 at z> 0) and as virtual interferograms in and behind the eye (in Figure 2 at z <0). observe and use not only punctually, but also on a surface basis, for KK interferometry on the eye. Because of the unusual anatomy of the eye compared to other organs (dominating of regular reflexes in contrast to otherwise dominating diffuse reflection), it is also possible to use localized interferences for measuring the length in the eye in z-positions outside the eye - with normal anatomy - and their extraaxial xy Transferred position analogously; Such RZI in front of the eye form the basis for the patent application described here.
    As an alternative to the double-beam KK interferometry described above, the eye can also be illuminated with a single, short-coherent light beam and the light coming from the eye can be split by a two-beam interferometer in FIG. 2 light beams offset from each other by a path length difference AL in the direction of propagation, and only an interferogram then generate when the path difference AL of these 2 light beams - within the coherence length lc - corresponds to the optical length of the distance between two boundary surfaces in the eye.
    Wavelength tuning interferometry (WT interferometry): A disadvantage of the above-described double-beam time-domain KK interferometry is the necessary tuning of the path difference AL in the interferometer as well as the fact that the instantaneous measurement signal or interferogram always only on light components with the associated AL based, the rest generates noise. In contrast, Fourier KK interferometry uses the entire light currently reflected from the object. In the WT interferometry variant of the Fourier-KK technique (also called "Swept-Source" or "Swept Wavelength Laser" KK interferometry), the ophthalmologic interferometer is illuminated in chronological order by a sequence of monochromatic light rays.
    The spectrum of the light reflections from the interferometer thus obtained is the Fourier transform of the magnitude of the scattering potential of the object or the object structure along the measuring beam, see equation (2) in section 4D-b.
    Cataract: The cataract (or: the cataract) is defined as optical inhomogeneity of the eye lens. These are turbidity and refraction inhomogeneities. At the age star, so-called water gaps (liquid-filled vacuoles or gaps) are observed. The Cataracta nuclearis (nuclear cataract) leads to a brownish turbidity and increase in refractive power. Frequently, mixed types of these morphological cataract forms occur. There is no drug therapy. Cataract surgery or cataract surgery is today the most commonly performed ophthalmic operation in the Western Hemisphere. In cataract surgery (eg in Germany about 400,000 p.a.), the natural eye lens is replaced by an artificial intraocular lens, for example of Plexiglas. KK interferometry in cataract: Compared to the ultrasound techniques used in the past, the ocular distance measurement using optical double beam KK interferometry precludes erroneous measurements under favorable conditions and leads quickly to the result in normal anatomy. However, current KK techniques, for example, are not sufficiently sensitive for denser cataracts. Here is a medical
    Supply gap, which, however, mainly affects patients in developing countries. Fourier KK interferometry solves this problem as well as the use of longer wavelengths only to a limited extent.
    The sensitivity of the KK interferometry is determined primarily by the power of the measuring beam at the measurement object. Higher sensitivity would be possible per se - due to the safety regulations limited power density of the illumination beam in the pupil - using the entire beam cross section of the light reflected by the eye at maximum open pupil. However, this is not readily possible because of the variable across the beam cross-section phase of the space-domain interferogram. The recently proposed by the applicant solution of this problem by the more sensitive space-time domain interferometry (AT 511 740 81) provides because of the larger energy flow in the measuring beam, a correspondingly high sensitivity, but requires complex image processing.
    Furthermore, the problem arises that many cataracts are inhomogeneous, which is why measuring beam diameter and measuring beam position must be made flexible.
    Even in unremarkable patients, a certain degree of variance of the eye parameters must be expected, which requires maximum flexibility in the illumination of the eye and the registration of the RZI.
    3. TECHNICAL TASK
    The invention is therefore based on the technical object to provide methods and arrangements for the ophthalmic length measurement, the position and diameter of the measuring beam within the pupil of the eye to be measured freely and allows high sensitivity short measurement times and applicability even with denser cataract. The invention will be explained with reference to the figures 1 and 2 with the detail numbers used there.
    The technical problem underlying the invention is achieved by means of double-beam space-time domain WT interferometry in that the subject eye 1 offset in chronological order corresponding to the double-beam KKI of a wavelength spectrum of monochromatic measuring double beams of two mutually temporally Coaxial components is illuminated and from the spectrum of the intensity data I (iv) (k) of the eye scattered and / or reflected stray field, the structure of the eye is calculated, in this case required for calculating the structure of the eye stray field intensity data I (k) of the Auges of transversal ξ-ζ // positions of longitudinally a few cm to dm away from the eye at z = Z real Fresnel zone-like space-time ---
    Domain interferograms RZI 51 are obtained by imaging on a photodetector array 70, the photodetector signal data is given to a computer 90, wherein for said imaging a zoom lens 52 in the output beam 49 of the optically coupled to the eye ophthalmic interferometer (Box [A]) is arranged to act as an inverse magnifying glass over its focal length adjustment from the RZI 51 positioned along the visual axis 48 of the differently striped contrast eye, that of maximum contrast to an image intensifier photocathode fixedly positioned in the z direction 53 or on such a photodetector array 70 allows imaging, and which is further positioned in the output beam 49 of the interferometer on the axis thereof, that occurring along the visual axis of the eye in the z direction increase the ring diameter of the RZI by the increasing distance from the Eye (1) in z-direction decreasing scale of picture of RZI the photodetector array 70 or the image intensifier photocathode 53 is compensated, wherein the interferometer illuminating monochromatic double rays different
    Wavelengths 11 are generated by a tunable laser 10 and a beam splitter 14 in a Michelson interferometer; Furthermore, that the eye 1 is illuminated by two fixation beams 31, 44 of different color coaxial with the measuring double beams for facilitating the adjustment of the eye, one of which, the direction of the eye fixing beam by imaging the exit surface 32 of a light-guiding optical fiber 33 by a Optic 34 is generated on the fundus of the eye, and its other, serving for positioning of the eye beam, illuminated by imaging a circular-shaped. Aperture 41 is generated on the dermis or on the environment of the pupil 2 of the eye 1 and further to control the state of the interferometer of the partial beams of the measuring double beam 11 in the double beam generating Michelson interferometer is reflected by a retroreflector 21, the periodically by small amounts, for example, by λ / 4, with sound frequency f is moved back and forth, so that a portion of the output beam 49, directed to a photodetector 81, with amplifier 82 and speaker 83, signaled by a beep of the frequency f that light off the BV reaches the ophthalmic interferometer via the eye. Here, the space-time domain technique ensures on the one hand high flexibility of the measurement by accessing IxJ parallel intraocular distances within arbitrarily large and flexibly configurable and positionable segments of the eye pupil, and thus on bases of the wave surface in these areas and thus also on the transfer function the optics of the eye and, alternatively, by summation or averaging the intraocular distance lengths within any pupil segments a significant increase in sensitivity. 4. DESCRIPTION OF THE INVENTION.
    The invention will be explained in more detail with reference to an embodiment of FIG 2.
    In the beam path of an arrangement according to the invention shown in FIG. 2, the ophthalmologic interferometer in the narrow sense [A], the fixation light components [B] and the device for checking and detecting the measurement signal [C] are delimited by dash-dot line boxes. 4A. Ophthalmic Interferometer: The method of measurement described here uses interferometers in an unconventional way in that the eye is not illuminated by a single measuring beam but by a measuring double beam generated by a Michelson interferometer. The Michelson interferometer in the narrower sense comprises the components 10 to 27. 9 is the hand of the observer performing the length measurement (medical assistant). 10 is the light source for the measuring double beam 11. The measuring light source 10 is a spatially coherent light source (DSL) tunable in its wavelength, for example a tunable, spatially coherent laser. The light beam 12 emitted by the measuring light source 10 is collimated by the optical system 13 and split by the beam splitter 14 into two partial beams 15 and 16.
    The partial beam 15 is reflected by the parallel to the beam direction (y-direction) movable measuring mirror 17 as a partial beam 24 of the measuring double beam 11 to the beam splitter 30. The retroreflector 17 is mounted on a translation table 18 which is controllably adjustable by hand 9 or by means of an electric drive 19 and whose y-position can be output by a built-in position sensor to the outside or read by a nonius 20 by the observer. Similar to the space-domain double-beam KK-interferometry technique, a path difference ΔL, which is intrinsic to the double beam 11, is also set here relative to the partial beam 16.
    This path difference plays an important role in solving the autocorrelation problem discussed in Section 4D-a.
    The partial beam 16 impinges on a retroreflector 21, which is mounted on a piezoactuator 22 and driven by the latter by an alternating voltage "U ~", periodically in the beam direction (z-direction) by small amounts, for example by 71/4, with a Tonfreguenz f As a result, the partial beam 23 of the measuring double beam 11 reflected here undergoes a time-periodic phase shift with respect to the partial beam 24. This serves to control the adjustment by audio signal and is triggered by the photodetector signal when the measurement is initiated or signal started interrupted, both reflected
    Partial beams 23 and 24 are finally reflected or transmitted by the beam splitter 14 as a measuring double beam 11 in the direction of the beam splitter 30 and reflected by the latter onto the eye (1).
    To adapt the measuring beam diameter to the pupil size of the existing eyepiece eyepiece 26 and lens 27 beam expander is used. The zoom eyepiece 26 is not shown in Figure 2 by the drawn convex lens-diverging lens combination in its actual structure, but only symbolically. (The same applies to the zoom optics 52 and 56.) 4B. Beam parameters and fixation of the subject's eye.
    The basic parameters of the measurement beam in the subject's pupil are beam intensity, beam diameter and wavelength as well as beam direction and beam position with respect to the direction and position of the visual axis of the eye.
    Beam intensity: The permissible limit for the irradiance (radiation power related to the beam cross-sectional area) of the light rays striking the eye is
    Safety regulations and depends, in addition to the wavelength, on the expected exposure time.
    Beam diameter: This determines, on the one hand, the total radiation power entering the eye and thus the achievable sensitivity of the length measurement. On the other hand, the beam diameter limits the illumination of the pupil and thus, for example, the maximum extent of the measurable transfer function of the eye.
    Wavelength: The dominant Rayleigh scattering increases with 1 // 14. The use of light of greater wavelength is therefore advantageous, but is increasingly limited by absorption in the tissue water from about λ = 1.4 to. (Currently, DSL's are commercially available in the wavelength range of about 680 nm to about 3 pm.)
    Beam direction with respect to visual axis: This is determined by the direction of the fixation beam 31, the patient looking at the light spot generated by the fixation beam on his retina. The fixation beam 31 is generated by imaging the exit surface 32 of the light guide 33 through the optics 34 and the optics of the patient's eye 1 via the beam splitters 40, 36 and 30 on the fundus. The optical fiber 33 is illuminated by a light-emitting diode (LED) 38, which emits green light, for example, whose light is focused by an optical system 35 on the entrance surface 37 of the optical fiber 33. The x-y position of the exit surface 32 of the optical fiber 33 determines the direction of the fixing beam 31; it is orthogonal to each other by means of a 2-coordinate adjustment device 39 in FIG
    Directions, such as x and y direction, positioned.
    Measuring beam position with respect to visual axis: This is controlled by means of a light ring projected onto the patient's eye. To produce this light ring, a circular-ring-shaped aperture 41 is imaged by means of a fixation light beam 44 through the optics 34, reflected by the beam splitter 36, and through the beam splitter 30 to the dermis or to the surroundings of the pupil 2 of the patient's eye 1. The aperture 41 is illuminated by means of an optical system 42 from the LED 43, which emits red light, for example. Thus, the patient can actively participate in the positioning. The position of the eye 1 is adjusted by a 2-coordinate adjustment device 45 in two mutually orthogonal directions, for example, x and y directions. As a criterion for the standard position of the patient's eye symmetrical brightness sensation of the patient at the wavelength or color of the light emitted by the LED 43 light can be used. 4C. Position control and RZI registration.
    A control of the positioning of the entrance pupil 2 of the patient's eye relative to the light ring image is by mapping the pupil plane by means of the zoom lens 52 at the interferometer output via the image intensifier (BV) in the
    Focal plane 60 of the eyepiece 61 allows. For this purpose, the focal length and / or z-position (the origin of z is in the center of curvature of the cornea, about 8 mm from the corneal vertex inside the anterior chamber of the eye) of the zoom lens 52 set so that the pupil 2 on the photocathode 53 of BV is mapped.
    Such a BV may for example be based on microchannel plate technology based on photocathode 53 at the input, microchannel plate 54 for amplification in the narrower sense, and phosphor screen 55 at the output of the BV. The spectral sensitivity of this BV is determined by the respective photocathode material. Above one
    Wavelength of 1 gm, however, decreases the detectivity of the solid-state photoreceptors available here with l / λ2. Alternatively, instead of such a BV, a digital camera based on CCD technology, electron multiplying CCD or intensified CCD technology can also be used. In the latter cases, the sensor of the digital camera replaces the photocathode, the phosphor screen 55 is replaced by the electronic camera viewfinder.
    Visual Position Control: The enhanced RZI appearing on the phosphor screen 55 of the BV facilitates finding the RZI by observers 100 (microscope analog optics 56 and 61) or observer 101 (by mapping to the array 70 and transmitting to the monitor by the computer 90) 91), especially in the case of irregular optics of the eye. In the plane of the phosphor screen 55 of the BV there is also a reticule 58 as an aid to the visual inspection of the present RZI position. The observation of the image on the BV output on the line cross arranged there facilitates the positioning and alignment of the subject's eye. (The latter can be readjusted by means of the fixing jet 31.)
    Adjustment control via audio signal. A somewhat blanket control of the calibration state of the ophthalmic interferometer is supported by an acoustic observation. For this purpose, in the output beam 49 of the ophthalmic interferometer, a beam splitter 80, which directs a portion of the output beam to a photodetector 81 with amplifier 82 and speaker 83. A tone of the frequency f occurring on the actuator 22 when the alternating voltage U ~ is switched on indicates that light from the ophthalmic interferometer reaches the BV via the eye.
    For interferometric measurement, by varying the focal length of the zoom lens 52, the contrast of an RZI 51 imaged on the BV is first optimized, then the RZI is imaged onto the photodetector array 70 by means of the part of the imaging beam 57 reflected by the beam splitter 59 and detected by its photodetector. Grid measured or "sampled".
    Fresnel Zone-Type Interferograms RZI 51: The eye-reflected light beam 50, here characterized by the "output beam" 49 of the ophthalmic interferometer, contains a series of 3-dimensional interference phenomena in the form of interference hollow cones of increasing diameter along the optical axis of the eye , With regular anatomy of the eye, all of these interferograms overlap, with the interferogram dominating the strong reflexes of the fundus and the two corneal reflexes. On the other hand, the corneal reflexes and the reflex of the posterior lens surface have almost the same radius of curvature and therefore the same interference state over almost the entire eye pupil, so that the (monochromatic) interferograms they form when illuminated with long coherence-length light are visually barely distinguishable visually. With irregular anatomy, such as cataract, you may not be able to observe complete or only speckle-like interferograms.
    The contrast-rich RZI of interest here are initially present as real interferences in the area in front of the cornea (z> 0) and as virtual interferences behind the cornea (at z <0). Real high-contrast interferences are located on the z-axis (several cm to dm) in front of the eye. For the zoom optics 52 arranged in front of the eye, these are virtual objects and are imaged by the latter - in the sense of an inversely acting magnifying glass - as real images onto the BV input or a photodetector array positioned there.
    These interferograms form the basis for the ophthalmological WT interferometry variant of the KK length measurement. In principle, a series of intraocular distances can be measured at each pupil point (x, y). For regular anatomy of the eye, because of dominating regular reflexes for the RZI, there is a clear association of the interferogram positions with the corresponding x-y position in the EP of the eye. Thus, for example, one obtains access to the distribution of the optical eye length cornea / fundus or the anterior chamber depth cornea / eye lens within the pupil. In any case, one can add the measured lengths over the entire pupil and thus receive a signal with very high sensitivity - but because of the
    Summation across different lengths at the price of reduced accuracy. Incidentally, the RZI 51 used for the measurement is located - as seen by the subject - behind the zoom lens 52 (at z> D). The distance of the RZI used for the measurement from the zoom optics therefore has no influence on the interferometer in the z direction. The zoom optics 52 can also adjoin the beam splitter 80 directly or, if the alignment aids are omitted, the beam splitter 36. 4D. SIGNAL PROCESSING. 4D-a. The WT interferometry or swept-source KK interferometry used here - there are several techniques based on the same optical principles with different but identical names - is based on the intensity spectrum Ιξψ (Υ) at the transversal
    Object position (ξ, ψ) emerging from the EYE light waves. These are generated by means of spectrally tunable laser as the light source, passed from a detector to a computer 90 and there deliver the object structure in the transverse object position (ξ, ψ) along the measuring beam in the ophthalmologic interferometer by Fourier transformation and autocorrelation decryption [A] ,
    In the method according to the invention, the stray field intensity spectrum Ix, y (k) of the patient's eye required for calculating the deep structure of the eye is determined from transversal positions of an RZI (51) which is located in the longitudinal z-direction a few cm to dm outside the patient's eye. registered by a photodetector array (70) and passed on to a computer (90) on. Because of the regular reflexes dominating at these intervals, even in moderate cataracts, a clear assignment of the RZI positions to the transverse pupillary coordinates is largely given. 4D-b. Fourier transform of the RZI array data. The PC 90 stores the spectrum of the ocular stray field intensities Ix, y (k) of the individual array photodetectors, calculates therefrom the partial path length data corresponding to the transverse positions (x, y) of the array photodetectors, and displays them on the connected monitor 91 dar.
    The array data is data matrices Ix, y (k) with
    (2) where FTZ = Fourier transform with respect to z-Kooddinate;
    is the wave number, λ is the wavelength of the light beam emitted by the DSL. Ix / y (k) are the spectral intensities associated with and registered by the individual array photodetectors due to light propagation outside the patient's eye pupil (via optics 52 and 56 and BV). In this case, the DSL 10 is tuned through a spectrum Δλ whose size determines the depth resolution, s. Equation (1).
    is the scattering of the eye or its "structure", n (x, y; z) is the corresponding refractive index.
    Signal strength is great at the backscattered light used here at sites of contiguous tissues with large scatter potential differences. Therefore, the z-positions of tissue boundaries ζ ^^ χ, γ) along each light beam in the eye pupil position (x, y) can be determined on the basis of the signal intensity peaks occurring there (the index Gi / Gj means "tissue boundary between tissue Gi and Tissue Gj "with, for example: G1 / G2 = Cornea anterior surface / Cornea inner surface, G1 / G3 = Cornea anterior surface / Lens anterior surface, G4 / G5 = Lens inner surface / fundus.) The corresponding partial segment lengths are obtained as the difference Δζ ^ of the z-values of these signal intensity peaks along the rays through the pupil position (x, y).
    Here are the following variants of use: (a) use of measured partial lengths Δζ ^ in the pupil to determine the optometric data or the transfer function of the patient's eye, (b) using the measurable subsets of the partial lengths AzGj / Qj (x, y ) in segments of the pupil, in particular in advanced cataract, (c) averaging the measurable segment lengths ΔzGi / GJ (x, y) over several or all pupil points to increase the sensitivity.
    Resolution and measuring range. The transverse resolution with which the RZI is registered is given by the classical Abbe's resolution formula by wavelength and numerical aperture of the image by the optic 52. Depth resolution is achieved by tuning the DSL 10 over a spectrum Ak. This is given by the coherence length of the imaging light beam.
    The size of the measurement range, on the other hand, is determined by the density of the k-axis sample values.
    Autocorrelation. However, an inverse FT of the intensity data of the photodetector array 70 provides - not just the object structure, but their
    Autocorrelation function. To solve this problem, there are a number of techniques that are described in detail in the literature (eg, Fercher et al., Opt. Commun., 117 (1995) 43-48 or Seelamantula et al.
    Opt. Soc. Am A, 25 (2008) 1762-1771) and can also be used here. 4D c. Size and contrast of the RZI; Role of the sampling or sampling theorem. Both position D and focal length of the zoom lens 52 determine the magnification of the RZI imaged on the photocathode 53 of the BV and further onto the array 70 - or on a photodetector array 70 located without the interposition of a BV. Basically, the RZI size at the photodetector array by means of zoom opacity 56, of course, should be chosen so that it is "scanned" at correct intervals by the array detectors in accordance with the sampling theorem. For example, with a 32x32 photodetector array, the central interferogram circular area of an RZI and, moreover, its ring structure can be scanned to the 4th fringe, in accordance with the sampling theorem. Compared to detection of the central interferogram circular area alone, this leads to a sensitivity gain of already 6 dB for the sum signal (neglecting the Gaussian profile and with homogeneous transparency of the eye media, the magnitude of the sum signal of the photodetector array decreases with the area of the registered RZI to). In addition, a 1000 x 1000 pixel photodetector array has a sensitivity potential on the order of 20 dB for sample theorem purposes. 4D-d. RZI size and sensitivity. However, optimal RZI contrast is present in individually different z positions (within a few cm to dm in front of the patient's eye). If, for contrast optimization, different z positions of the RZI 51 (via the optics 52 and 56 and the BV) are formed on the detector array 70, this is done individually because of the required tuning of the focal length of the zoom lens 52 from the parameters of the eye dependent imaging scales. Scanning the size-varying image of the RZI 51 on the photodetector array 70, therefore, often results in "under-sampling" or "oversampling", thereby degrading image quality and sensitivity.
    Homogenization of RZI size. Thus, 2 steps are required to optimize the signal: 1. Locate an RZI with optimal contrast along the z-axis. 2. Scanning theorem representation of the RZI from the phosphor screen 55 of the BV by zoom optics 56 onto the photodetector array 70. This is a 2-dimensional variety of possibilities and therefore impractical.
    Since the ring diameters of the RZI, caused by the increase in the radii of curvature of the propagating corneal reflexes, increase with increasing distance z from the patient's eye, the imaging scale of the RZI on the
    However, as the photocathode of the BV decreases with increasing distance from the optic 52, one can compensate for the change in size of the RZI along the z-axis by appropriate choice of the RZI imaging scale-that is, by appropriate choice of position and / or focal length of the zoom optic 52. As an example, assume a positioning of the zoom lens 52 at z = D = 60 mm in front of the eye 1. This achieves - by corresponding zoom optics focal length 52 - a constancy of the photocathode 53 imaged RZI ring diameter of better than + / - 5% for z positions between z = 100 mm to - 600 mm.
    Alternatively, instead of tuning the focal length of the zoom opaquen 52, one can shift the device for detecting the measurement signal [C] along the z-axis (eg to position C ', see open arrow 71). 4D-e. Strong inhomogeneous transparency of the patient eye media. In such cases, there is a gain in the method according to the invention in that the much larger compared to the single detector detector array to a considerable facilitation of the otherwise standard in the standard spectral interferometry with a single tiny detector much cumbersome signal search and also a segmentation histologically related areas allowed ,
    5.FIGUREN
    Figure la: Purkinje-Sanson images PI, P2, P3, P4 ..
    Figure lb: Fresnel zone-like space-time domain interferogram (RZI), embedded in the mat of the speckle structure in front of the eye.
    FIG. 1c: Enlarged section of the RZI from FIG. 1c.
    权利要求:
    Claims (9)
    [1]
    Dr. Adolf Friedrich Fercher, Hassreitersteig 3/11, 1230 Wien PATENT APPLICATION OPHTHALMOLOGICAL LENGTH MEASUREMENT BY DOUBLE JET SPACE TIME DOMAIN WAVELENGTH TUNING SHORT COHERENCE INTERFEROMETRY PATENT CLAIMS 1) Arrangement for ophthalmic length measurement by means of double beam space-time domain Wavelength tuning interferometry, in which the patient's eye ( 1) from a measuring double beam (11) from a two-beam interferometer [A] is illuminated in turn by a tunable laser (10) and so at the output of the interferometer [A] a tunable measuring double beam (11) produced in pairs monochromatic, time-shifted coaxial components (23 and 24), which illuminates the patient's eye (1) after reflection on a beam splitter (30), and from the spectrum of the stray field intensity data Ιξ, ψ (^ of the test person's eye (1) scattered and / or reflected stray field - marked in Figure 1 as output beam (49) - the structure of the A. is calculated, characterized in that for the calculation of the structure of the eye required stray field intensity data Ιξ, ψ (^ from the output beam (49) of the eye in transverse ξ-ψ positions from longitudinally a few cm to dm outside the Prougenauges (1 ) virtually localized RZI (51) from an optic (52) to the input of an image intensifier consisting of, for example, photocathode 53 at the input, microchannel plate 54 for image enhancement and phosphor screen 55 at its output, and amplified therefrom onto a photodetector array (70). projected and passed on to a computer (90).
    [2]
    2) Arrangement for ophthalmological length measurement by means of double-beam (11) based space-time domain Wavelength Tuning Interferometry, characterized in that zoom optics (52) in the output beam (49) of the ophthalmic interferometer are arranged so that they, as inverse Magnifying glass, via its focal length adjustment along the visual axis (48) of the eye, in the z-direction differently positioned space-time domain interferograms (51) on a z-direction fixed position of an image intensifier photocathode (53) or a photodetector Imaging arrays (70).
    [3]
    3) Arrangement for ophthalmic length measurement using double-beam (11) -based space-time domain Wavelength Tuning Interferometry, characterized in that space-time domain interferograms (51) on image intensifier photocathode (53) or photodetector array (70) imaging zoom optics (52) in the output beam (49) are positioned on the z-axis (at z = D) so that an increase in the ring diameters of the Fresnel-zone-like space-time domain interferograms along the visual axis of the eye ( in the z-direction) is compensated by the decreasing with increasing distance from the eye (1) in the z-direction scale of the image of the RZI on the photodetector array (70) or the image intensifier photocathode (53).
    [4]
    4) Arrangement according to claims 1, 2 and 3, characterized in that monochromatic double beams (11) of different wavelengths of a tunable laser (10) and a beam splitter (14) are generated in a Michelson interferometer.
    [5]
    5) Arrangement according to claim 1, 2, 3 and 4, characterized in that the patient's eyes (1) of two to the measuring double beams (11) coaxial fixing beams (31, 44) of different colors for the adjustment of the patient's eye (1) are illuminated ,
    [6]
    6) Arrangement according to claim 1 and 5, characterized in that fixing beams (31) for the direction of the patient's eye (1) by imaging the exit surface (32) of a light-guiding light guide (33) by an optical system (34) on the fundus of the eye will be realized.
    [7]
    7) Arrangement according to claim 1 and 5, characterized in that a fixing beams (44) for the position of the patient's eye (1) by means of a projected onto the patient eye light ring by imaging a circular ring-shaped illuminated aperture (41) on the dermis or to the environment the pupil (2) of the patient's eye (1) can be realized.
    [8]
    8) Arrangement according to claims 1, 2 and 3, characterized in that one of the partial beams of the measuring double beam (11) in the double-beam generating Michelson interferometer ([A]) is reflected by a retroreflector (21), the periodically by small amounts, for example, by λ / 4, with sound frequency is moved back and forth.
    [9]
    9) Arrangement according to claim 1, characterized in that arranged in the output beam (49) of the ophthalmic interferometer beam splitter (80) directs a portion of the output beam to a photodetector 81 with amplifier 82 and speaker 83.
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    AT518602B1|2019-02-15|
    DE112017002314A5|2019-02-14|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    DE102011011277A1|2011-02-11|2012-08-16|Carl Zeiss Meditec Ag|Optimized device for swept source Optical Coherence Domain Reflectometry and Tomography|
    AT511740A2|2011-07-18|2013-02-15|Adolf Friedrich Dr Fercher|PROCEDURE AND ARRANGEMENTS FOR SPACE-TIME DOMAIN SHORT COHERENCE INTERFEROMETRY FOR OPHTHALMOLOGICAL PARTIAL LENGTH MEASUREMENT AND CORNEA TOPOGRAPHY|
    IL221187A|2012-07-30|2017-01-31|Adom Advanced Optical Tech Ltd|System for performing dual beam, two-dimensional optical coherence tomography |US10916163B1|2019-10-29|2021-02-09|Disney Enterprises, Inc.|Large-scale infinity optics window for use in small facility packaging applications|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    ATA226/2016A|AT518602B1|2016-05-03|2016-05-03|Ophthalmic length measurement using a double-beam space-time domain Wavelength Tuning Short-coherence interferometry|ATA226/2016A| AT518602B1|2016-05-03|2016-05-03|Ophthalmic length measurement using a double-beam space-time domain Wavelength Tuning Short-coherence interferometry|
    US16/097,609| US20200323429A1|2016-05-03|2017-05-02|Ophthalmological length measurement by means of dual-beam space-time domain wavelength tuning low-coherence interferometry|
    PCT/EP2017/060410| WO2017191128A1|2016-05-03|2017-05-02|Ophthalmological length measurement by means of dual-beam space-time domain wavelength tuning low-coherence interferometry|
    DE112017002314.9T| DE112017002314A5|2016-05-03|2017-05-02|Ophthalmic length measurement using a double-beam space-time domain Wavelength Tuning Short-coherence interferometry|
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