• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to an animal feed additive containing oligomeric procyanidins for the treatment or prophylaxis of acute or subacute rumen acidosis or rumen acid resulting from rumen acidosis.
    公开号:AT513228A1
    申请号:T904/2012
    申请日:2012-08-20
    公开日:2014-02-15
    发明作者:
    申请人:Neufeld Klaus；
    IPC主号:
    专利说明:

    51531 • · · · ···· ······ ···
    Animal feed or drinking water additive for ruminants
    Field of the invention
    The invention relates to additives for animal feed or drinking water for ruminants.
    Background of the invention
    Agricultural animal production today aims to achieve an acceptable level of performance of livestock and high health status under the most economical conditions possible. It has been shown that a good state of health as a result also leads to good performance in terms of growth, milk production, wool production, reproduction, etc. In the past, attempts have been made to increase the level of performance by so-called nutritional benefits of antimicrobial agents (e.g., antibiotics). For example, in the area of ruminants, the product Flavomycin® (name of substance: flavophospholipol) has been used for a long time [Van der Merwe BJ et al .: The effect of flavophospholipol (Flavomycin®) on milk production and milk urea nitrogen concentrations of grazing dairy cows, South African Journal of Animal Science (SASAS) 2001, 31 (2): 101-105]. Another example of the group of these substances are the ionophoric antibiotics, for example the product rumensin (name of the substance: monensin sodium) [Callaway TR et al: ionophores: their use as ruminant growth promoters and impact on food safety, Curr. Issues Intest. Microbiol. 2003, 4: 43-51].
    The use of antimicrobial agents has significant disadvantages. On the one hand, from a scientific point of view, a positive effect of these substances on the performance level of farm animals has not always been demonstrated [Gritzer K and Leitgeb R: Testing the effectiveness of antibiotic and microbial performance enhancers in cattle fattening, Die Bodenkultur, 1998, 49 (1): 51-59] On the other hand, however, there has been a trend in the consumer field towards natural and residue-free animal foods, which has created a resistance to the use of such substances in agriculture, both in commerce and in the consumer. In addition, there has been a scientific suspicion that it is due to the use of antibiotic performance enhancers in 2/20 k. Agriculture may lead to the development of resistance to antibiotics, in particular for use in human medicine. So-called live yeasts have been used as alternative products in recent years. Their promoting effect on bacteria in the rumen and their pH-stabilizing effect in the rumen through a better utilization of lactic acid are known [Schmitz W: Living yeast: small cells with great effect, the progressive farmer 2010, 20: 10-12].
    At the veterinary level, however, it has been found that the greatest capacity for optimal performance of livestock is the maintenance of optimal health. In the ruminant farm animals, such as cows, sheep or goats, there are two major metabolic problems that lead to significant performance losses. These are on the one hand to ketosis, on the other hand to the acidosis, in particular the subacute acidosis (SARA). Ketosis and acidosis are approximately equivalent in their economic importance.
    Subacute Romaine Acidosis (SARA) occurs at a rate of 10% to 30% of dairy cows, depending on the type of land and husbandry being studied. For example, Enemark and Jorgensen (2001) report a prevalence of 22% in dairy cattle in Denmark, Oetzel (2003) indicates the incidence of subclinical rumen acidosis in fresh-lactating cows at 15%. Thus, in addition to ketosis, acidosis represents the largest and, from an economic point of view, the most important health problem in cattle production.
    State of the art
    Previous methods to prevent rumen acidosis are of limited effectiveness. Usually buffer substances, in particular sodium bicarbonate, are added to the animal feed. However, at effective doses of> 150 g per animal per day, sodium bicarbonate leads to reduced feed intake and can therefore only be used to a limited extent.
    EP 1 175 696 discloses the use of acarbose and trestatines for the manufacture of a medicament for the curative, palliative and prophylactic treatment of rumen acidosis. 3/20 ···· ···· «· · · · · · ························ ...... 51531
    Disclosure of the invention
    The object of the present invention is to provide agents for the treatment or prophylaxis of acute or subacute rumen acidosis or rumen acidosis resulting from rumen acidosis. These agents include an animal feed, an animal feed supplement or a premix for the manufacture of an animal feed and a drinking water additive.
    In one aspect, the present invention provides an animal feed additive containing oligomeric procyanidines for the treatment or prophylaxis of acute or subacute rumen acidosis or ruminal acidosis resulting from rumen acidosis.
    In one aspect of the invention, the oligomeric procyanidines may be included in the animal feed additive in the form of ground pine or elm bark, or as pine bark or elm bark extract, or as a mixture thereof.
    In the context of the present invention, it has surprisingly been found that the bark of pine species (Pinus spp.) Or elms (Ulmus spp.) Or extracts of such bark have a positive, even preventive, effect on the acidosis event. This is done physiologically, in particular, by the oligomeric procyanidins contained in the bark (which are also referred to as proanthocyanidins). For these substances, an inhibitory effect on rumen acidase in the context of in vitro disease with rumen fluid could be demonstrated.
    From a physiological point of view, it is important that in animals that do not develop rumen acidosis or are not susceptible to them, no inhibition of rumen takes place, since such inhibition in "healthy" animals to a derailment of rumen fermentation and subsequently to health disorders and can lead to a performance depression. The inhibitors of rumen amylase (e.g., acarbose) used in the art are known to inhibit rumen amanase regardless of the animal's health. 4/20 • · • · • • • • • • • · · · · · · · · · · · · · · · · · · · · · · · ·······················································
    Extensive studies have been made within the scope of the present invention, and it has surprisingly been found that pine bark, elm bark or extracts thereof exhibit a mechanism of action which is triggered (i.e., triggered) by a decrease in pH (i.e., an acidity increase). The oligomeric procyanidins contained in the pine and elm bark are released and thus active by a drop in the pH in the area sensitive to the development of rumen acidosis or subacute rumen acidosis. The amount released and the rate of release can be influenced by the degree of extraction of the bark. The ground, i. Bark which has not been extracted shows the greatest delay in the release of active substance and has therefore proved to be the most effective in practice in avoiding a pH drop in azido-susceptible animals by inhibiting rumen-induced pansenamylase, without taking the risk in healthy or non-sensitive animals Unnecessarily disrupting rumen physiology.
    As used in this specification, the terms "acute rumen acidosis" and "subacute rumen acidosis" are to be understood as follows. Acute rumen acidosis is caused by an excessive fermentation activity in the rumen with resulting formation of acids as metabolites of the fermentation process. The reason for this is often a high level of concentrate feed, which is necessary at the onset of lactation in order to limit the resulting energy deficit due to milk production. A long-lasting decrease in the pH in the rumen below a value of 5.5 causes a change in the rumen flora, cessation of re-killing, inappetence, diarrhea, colic, severe disturbances of the general condition and lying. The low pH damages the mucous membrane of the rumen, which then can no longer fulfill its barrier function. The transfer of bacteria, fungi, biogenic amines and bacterial toxins from the rumen into the organism is favored and worsens the clinical picture. SARA (subacute ruminal acidosis) is a common problem in cattle production. SARA is associated with a decrease in rumen pH below the physiological norm. The cause of rumen acidosis is usually an oversupply of rapidly fermentable carbohydrates, often in conjunction with a shortage of structured crude fiber. In contrast to acute rumen acidosis, the phases of a nonphysiologically low pH (below 5.8) in SARA are 5/20 in time
    51531 limits and lasts from a few minutes to several hours. If these acidotic phases persist for longer than three to four hours, morphological damage to the rumen of the rumen occurs, which usually can only be detected post mortem. This damage, in turn, causes an increased permeability to bacteria, biogenic amines, fungi and bacterial toxins, which cause inflammation in the organism and promote liver damage and claw diseases. The following diseases occur: claw diseases (laminitis), disorders of the liver health (especially abscesses), fertility disorders, reduced milk yield and reduced meat intake in cattle. Furthermore, disturbance of the physiology of the rumen villi leads to loss of appetite (inappetence) and a change in the consistency of the faeces (that is, the feces become thin-skinned to watery).
    Examples of rumen acidiferous conditions in a ruminant treated, reduced or prevented by adding ground pine or elm bark or pine bark or elm bark extract or a mixture thereof to the animal feed or drinking water are rumen pH lowering, rumen flora derailment , Cessation of ruminant activity, decrease in milk yield, decrease in milk fat content, chronic metabolic stress, burden of liver metabolism, infertility, prolonged remission rate, lower calf count and inflammatory claw diseases.
    In another aspect, the invention features a ruminant animal feed comprising the animal feed supplement containing oligomeric procyanidins in an amount effective for the treatment or prophylaxis of acute or subacute rumen acidosis or ruminal acidosis conditions in a ruminant, and one or more feed components from the group consisting of protein carriers, carbohydrate carriers, roughage, silages, fats, vitamins, minerals and trace elements.
    The structure of the feed ration for ruminating farm animals is basically as follows: 6/20
    Basic feeds: these are normally farm-owned feeds such as pasture and grass canned (hay, silage), forage and forage (lucerne silage), by-products (for example, spent grains).
    Power and supplementary feeds (depending on performance): In-house cereals, by-products from flour, sugar and oil processing as well as supplemented vitaminised mineral feed. Today, the use of special supplementary feeds for dairy cattle (e.g., dairy feed) or supplementary feed for cattle fattening (commonly referred to as concentrates or bovine fodder) is common practice.
    Daily feed intake for forage is usually expressed in kilograms of dry matter (kg DM) for livestock. For example, in dairy cows, the dry matter intake capacity is 3 to 3.8 percent of the body mass, in fattening bulls 1.6 to 2.5 percent of the body mass. For example, in dairy cows, the daily intake of dry matter is usually 15 to 20 kilograms. The daily concentrates for dairy cattle feed (= dairy feed) are around 5 to 10 kilograms per animal per day, with a fattening feed at around 2 to 3 kilograms per animal per day.
    The animal feed additive containing oligomeric procyanidines may be administered mixed with the animal feed (for example, basic feed, milk feed, concentrated feed, etc.), or it may be added on top to the respective feed rations.
    The animal feed according to the invention contains the animal feed supplement containing oligomeric procyanidins in the form of ground pine or elm bark in an amount corresponding to the administration of 0.1 to 500 g of ground pine or elm bark per day per animal. Alternatively, the animal feed according to the invention contains the animal food supplement containing oligomeric procyanidins in the form of pine bark or elm bark extract in an amount corresponding to the administration of 0.002 to 100 g of pine bark extract or elm bark extract per day per animal.
    The amount of ground pine and / or elm bark used in the animal feed of the present invention may vary in the range of 0.01 g to 250 g of ground bark per kilogram of feed dry matter. For example, the animal feed contains ····· ···· * · 7 * ......... 51531 preferably 0.01 g to 100 g of ground pine or elm bark per kilogram of milk yield feed (concentrate for dairy cows), 0 , 03 g to 250 g of ground pine or elm bark per kilogram of fattening feed (concentrates for cattle) and 0.03 g to 250 g of ground pine or elm bark per kilogram concentrated feed for small ruminants (eg dairy sheep, meat sheep, wool sheep, dairy goats, meat goats).
    The amount of pine and / or elm bark extract used in the animal feed according to the invention can vary in the range of 0.002 g to 50 g bark extract per kilogram dry matter feed. For example, the animal feed preferably contains 0.002 g to 20 g of pine or elm bark extract per kilogram of milk power feed, 0.002 g to 50 g of pine or elm bark extract per kilogram of fattening feed (concentrates for cattle) and 0.002 to 50 g of pine or elm bark extract per kilogram concentrated feed for small ruminants (eg dairy sheep, meat sheep, wool sheep, dairy goats, meat goats).
    In another aspect, the invention relates to a premix for making an animal feed, the premix containing the oligomeric procyidine-containing animal feed additive for the treatment or prophylaxis of acute or subacute rumen acidosis or conditions resulting from rumen acidosis together with one or more feed components selected from the group consisting of protein carriers , Carbohydrate carriers, roughage, silages, fats, vitamins, minerals and trace elements.
    The invention also relates to the use of an animal feed additive according to the invention or a premix containing an animal feed additive according to the invention for the production of an animal feed.
    In another aspect, the invention relates to the use of ground pine or elm bark or pine bark or elm bark extract or a mixture thereof for the manufacture of an animal feed additive or animal feed premix or animal feed for the treatment or prophylaxis of acute or subacute rumen acidosis or conditions resulting from rumen acidosis a ruminant. 8/20 • · 51531
    When the animal feed contains the oligomeric procyanidins in the form of ground pine bark or ground elm bark, the dosage is preferably in the range of 0.1 to 500 gm of ground pine or elm bark per day per animal. When the animal feed contains the oligomeric procyanidins in the form of pine bark extract or elm bark extract, the dosage is preferably in the range of 0.002 to 100 grams of pine bark or elm bark extract per day per animal.
    According to a further embodiment of the invention, the pine bark or elm bark extract containing oligomeric procyanidins, preferably in the form of a water-soluble extract, can also be added to the drinking water for ruminants. The amount of bark extract used in the drinking water can vary in the range of 0.00008 g to 100 g of extract per liter of water. Alternatively, ground pine and / or elm bark may be slurried with the drinking water. In this case, for example, the dosage may vary between 0.1 and 500 g per animal per day.
    The production of the bark extracts can be carried out by methods known per se, such as solid-liquid extraction with water, hot water or steam or with organic solvents such as ethanol or methanol or with solvent mixtures or mixtures of such solvents with water or by extraction with supercritical CO2 as extractant , The degree of extraction can be optimized by hydrolytic or other catalytically degrading (e.g., enzymatic, especially cellulolytic enzymes such as cellulases) conditions. Preferably, the extraction is carried out at temperatures in the range of 50 ° C to 300 ° C.
    To optimize the Procyanidineehaltes bark is preferably ground and extracted the powder thus obtained in a percolator with 0.1 molar hydrochloric acid solution as extractant at a temperature of 100 ° C. The extract is then evaporated and taken up in water.
    Another preferred extraction method is the supercritical CO 2 extraction, which uses supercritical CO2 as the extractant and at a flow rate of 1200 to 1400 liters per hour over a period of 4 hours 9/20 ···· ···· ·· * 51531 at a pressure of 25. English:. German: v3.espacenet.com/textdoc to 30 MPa and a temperature of 50 ° C to 70 ° C is extracted. The extract is then taken up in ethanol.
    Standardization of the content of oligomeric procyanidines can be carried out by HPLC analysis from the extracts obtained.
    Short description of the drawing
    In the following the invention will be explained in more detail by means of examples with reference to the drawing. In the drawing, Figure 1 shows the course of the temperature and the pH in the rumen for (A) an acidosis-sensitive animal and for (B) an acidosis-insensitive animal.
    EXAMPLES
    Example 1: In vitro tests with oligomeric procvanidins
    Healthy, untreated, rumen-furred bulls were removed from rumen fluid, centrifuged off and the supernatant frozen immediately. 10 ml of the thawed rumen fluid was mixed with 0.5 g of the substance according to the invention and stirred for 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes, 210 minutes and 240 minutes at 39 ° C. by means of a magnetic stirrer. The supernatant was pipetted off at the indicated time and the amylase activity was measured. For this purpose, a commercially available ELISA system was used, which is usually used to determine the amylase activity in the blood serum.
    Table 1: Amylase measurement in rumen juice
    Time rumen fluid without rumen fluid with addition of oligomeric test substance Procyanidines according to the invention (control) [U / l] [min] [U / H 60 209 129 90 212 153 120 197 149 150 211 159 180 204 153 210 194 163 240 181 167 10 / 20 ··············································································································································································································· ...... 51531
    As is clear from Table 1, the oligomeric procyanidins used according to the invention cause an inhibition of the amylase activity.
    Example 2: / n-wVoVersuche with fattening bulls
    As stated above, it is important from a physiological point of view that no inhibition of rumen amylase occurs in animals that do not develop rumen acidosis or are unresponsive to it. Such inhibition can lead to a derailment of rumen fermentation in healthy animals, which in turn causes health disorders and performance depression.
    This example shows that the subject substance (e.g., pine bark extract) of the present invention, depending on the degree of extraction, exhibits a mechanism of action due to a decrease in pH (i.e., an acidity increase). Extensive research has shown that the pine bark oligomeric procyanidins are released and thus become active by an increase in acidity (i.e., pH drop) to an area where the development of (subacute) rumen acidosis is expected. The amount released and the rate of release may be affected by the degree of extraction of the bark.
    Ground bark has the greatest delay in drug release compared to bark extracts. It is therefore particularly advantageous in practice when it comes to specifically avoid a pH drop in azido susceptible animals on the inhibition of pansenamylase, without taking the risk of unnecessarily disturbing the rumen physiology in healthy or non-sensitive animals ( see FIGS. 1A and 1B).
    These findings were obtained in extensive experiments using pansenboli, whereby the influence of oligomeric procyanidins in fattening bulls was investigated. The used pansenboli are measuring sensors, whereby one sensor is placed in the rumen of the test animal. The sensor continuously measures both the pH and the temperature within a few minutes and stores this data. An external data storage station calls this 11/20 ····· · ··· ** 11 * ......... 51531
    Data several times a day and forwards them to a computer for data analysis.
    Therefore, fattening bulls were used for the experiments (and preferred to dairy cows) because, in the case of dairy cows, the utilization of volatile fatty acids for milk production differs according to the stage of lactation and milk yield and would thus be another influencing factor.
    The experiments with Pansenboli were carried out on six fattening oxen over a period of nine weeks in Latin Square. On the one hand, experimental feed containing oligomeric procyanidins in two different dosages and control feed without admixture of an animal feed additive according to the invention were used. The experimental scheme is shown in Table 2 below.
    Table 2:
    Control Feed Trials Feed Trial Dosage 1 Dose 2 Period 1 (3 weeks) Animal 1 Animal 3 Animal 5 Animal 2 Animal 4 Animal 6 Period 2 (3 weeks) Animal 5 Animal 1 Animal 3 Animal 6 Animal 2 Animal 4 Period 3 (3 weeks) Animal 3 Tier 5 Tier 1 Tier 4 Tier 6 Tier 2
    The animals were fed a diet of concentrated feed, maize silage and hay, the concentrate being equal parts of barley, wheat and soy HP (i.e. high protein soybean meal). The composition of the feed is shown in Table 3 below. During the experimental periods, the animal feed of the animal feed according to the invention was mixed on-top. The feed additive containing oligomeric procyanidins was fed in the case of the test diet in two different dosages (15 g per animal per day and 30 g per animal per day, respectively). 12/20
    Table 3:
    Corn silage kg 9,09 concentrated feed kg 2,73 hay kg 0,69 concentrate composition: 33,3% barley, 33,3% wheat, 33,3% soy HP
    Figure 1 shows the rumen pH and rumen temperature measured with rumen boluses for an acidosis-sensitive animal (Figure 1A) and for an acidosis-insensitive animal (Figure 1B).
    In the acidosis-sensitive animal, provocative feeding with the high-starch animal feed occurred in the control phase, i. without administration of the feed additive according to the invention, to a decrease in the pH. In contrast, during the experimental phase, i. for the duration of administration of the animal feed additive according to the invention, higher pH values. This confirms the effectiveness of the animal feed additive according to the invention for the treatment or prophylaxis of rumen acidosis.
    In the case of the acidosis-insensitive animal, in the control phase, i. without the animal feed additive according to the invention, no lowering of the rumen pH. There was no disturbance of the rumen physiology in the experimental phase. This result confirms the above-described mechanism of action of the animal feed additive according to the invention. In healthy or acidosis-sensitive animals, the rumen physiology is not disturbed by the animal feed additive according to the invention, since the necessary to trigger its effect, the decrease in the pH in the rumen does not occur.
    Example 3: / n-wVo experiments with dairy cows
    This trial was a field trial in a dairy farm. During the trial phase, all lactating dairy cows of the herd were fed 30 g elm bark on the top of the barn ration. Data from routine livestock herd health routines were compared to previous data, which were evaluated as control data (without bark supplementation). • • • • • • • • • •••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••
    As laboratory animals 40 lactating dairy cows could be evaluated. The animal feed administered was the feed mentioned in Example 4. The dosage of the animal feed additive according to the invention was 30 g elm bark per animal per day.
    In the context of these experiments in dairy cows, it was found that the animal feed additive according to the invention led to a higher milk yield, in particular during critical phases of lactation. As Table 4 below clearly shows, this effect was surprisingly not associated with the depression of milk fat content to be expected from a technical point of view. The effect of the animal feed additive according to the invention is therefore in sharp contrast to the teaching of the prior art, which states that an increase in milk yield is always associated with a drop in milk fat content.
    Table 4: Milk and milk fat content of animals at risk of acidosis
    Routine heroin trial Time 1 Control Time 2 Control Time 3 Trial Number of cows above 35 kg Milk output 16 16 11 Milk volume in kg 39.9 38.9 41.3 Milk fat content in% 4.21 4.23 4.26 Number of first lactating cows in the lactation period Day 1 to 100 3 4 4 Milk volume in kg 23.2 29.5 33.6 Milk fat content in% 4.71 4.23 4.33 Number of cows from 2. Lactation in the lactation period Day 1 to 100 9 10 6 Milk volume in kg 41.0 39.8 43.3 Milk fat content in% 4.06 4.11 4.26
    Also of interest are the routinely collected herd health parameters: the urea content of the milk serves as an indicator of protein supply. The protein content of the milk is an indicator of the energy supply of the animal. The two parameters are to be assessed together as urea / protein and are divided into nine classes. The value should be in the middle field (class 5). 14/20 • ······ ...... 51531
    Deviations mean over or under supply of protein and / or energy.
    Metabolism control urea / protein (urea class, HKI) without animal feed additive according to the invention:
    A maximum of 47.5% of the animals were categorized in the optimal class 5, up to 42.5% of the animals were in the unfavorable classes 2 (lack of energy) and 7, 8 and 9 (protein surplus and / or energy surplus).
    Metabolism control urea / protein (HKI) with animal feed supplement according to the invention: 70.7% of the animals were categorized in the optimal class 5, 9.8% in class 2, 17.1% in class 8, no animal was designated as class 9.
    The parameter metabolic control energy supply describes the energy supply of the animal over the protein content of the milk. A protein content of 3.2% to 3.8% is classified as normal, there is an over-energy supply, including an energy shortage. In principle, a lack of energy is accompanied by a decrease in the milk protein content.
    Metabolism control Energy supply without animal feed supplement according to the invention: Around 58% of the animals were in the "normal" range, up to 35% of the animals in the "energy exceeded" range.
    Metabolism control energy supply with inventive animal feed supplement: Around 73% of the animals were in the "normal" range, only 17% of the animals in the "energy exceeded" range.
    The significant improvement in these parameters, which reflect the rumen health and metabolic status, indicates that the animal feed or drinking water additive according to the invention actually leads to an improvement in the rumen physiology and thus the overall metabolic situation of the animals. 15/20 • · · · ···· ························································································ ··· ·· 15 51531
    Example 4: Inventive animal feed for dairy cows
    This example gives a composition of a compensatory feed for dairy cows.
    Commodity Dry matter Share in% Corn 880 10.00 Barley 870 15.00 Wheat 870 11.50 Soybean meal 870 10.00 Corn power feed 880 5.00 Rapeseed meal 886 15.00 Wheat feed meal 882 5.00 Wheat bran 880 10.00 Dry cuts 906 15.00 Feed lime 980 1.20 Pine or elm bark 920 0.30 Mineral mixture 900 2.00 100.00 Nutrient Unit Content Dry matter% 88.34 Net energy lactation (NEL) MJ 6.59 ME ruminant *) MJ 10.50 Crude protein% 17.72 Crude fiber% 8.14 Calcium o / o 0.89 Phosphor% 0.60 Sodium% 0.36 Magnesium% 0.35 Ca: P = 1.49: 1 milk from protein I 2.09 milk from NEL I 2,10 *) Metabolic Energy: Energy Assessment Scheme for Ruminants 16/20 • · · · · · · · · · f
    • · · · · · · ················································· 51531
    Example 5 Inventive animal feed for cattle fattening
    This example gives a composition of power feed for cattle.
    Raw material Dry matter Proportion in% Barley 870 9.80 Wheat 870 10.00 Soybean meal 870 19.00 Cornflour 880 5.00 Rapeseed meal 886 20.00 Wheatfat flour 882 5.00 Wheat bran 880 10.00 Dry cuts 906 15.00 Feed lime 980 2.00 Cattle salt 900 0.20 Pine or elm bark 920 1.00 Mineral mixture 900 3.00 100.00 Nutrient Unit Content T rock substance% 88.39 ME ruminant *) MJ 10.29 Crude protein% 22.01 Crude fiber% 8.90 Calcium % 1,74 Phosphorus% 0,76 Calcium: Phosphorus = 2,29: 1 Sodium% 0,31 Magnesium% 0,44 Vitamin D IE 3900 Vitamin E mg 19 Vitamin B1 mg 1,56 ME-W *) / kg Dry matter MJ 11.65% crude fiber / kg dry matter 10.07 *) Metabolic Energy: Energy assessment scheme for ruminants
    Such feed is basically also suitable for small ruminants such as sheep in milk, meat and wool production and goats in milk and meat production. 17/20
    权利要求:
    Claims (14)
    [1]
    • • • • • • • • .. 1r • ♦ · ·

    1. Animal feed supplement, characterized in that it contains oligomeric procyanidins for the treatment or prophylaxis of acute or subacute rumen acidosis or conditions resulting from rumen acidosis in a ruminant.
    [2]
    2. Animal feed additive according to claim 1, characterized in that the oligomeric procyanidins are contained in the form of ground pine or elm bark or in the form of pine bark or elm bark extract or mixtures thereof.
    [3]
    3. animal feed for ruminants, characterized in that it contains an animal feed additive according to claim 1 in an effective amount for the treatment or prophylaxis of rumen acidosis or conditions resulting from rumen acidosis together with one or more feed components selected from the group consisting of protein carriers, carbohydrate carriers, roughage, silage , Fats, vitamins, minerals and trace elements.
    [4]
    4. animal feed according to claim 3, characterized in that it contains 0.01 g to 250 g of ground pine or elm bark per kilogram dry matter feed.
    [5]
    5. animal feed according to claim 3, characterized in that it contains 0.002 g to 50 g of pine bark or elm bark extract per kilogram dry matter feed.
    [6]
    6. animal feed according to claim 3, characterized in that the animal feed additive is contained according to claim 1 in the form of ground pine or elm bark in an amount corresponding to the administration of 0.1 to 500 g of ground pine or elm bark per day per animal.
    [7]
    7. Animal feed according to claim 3, characterized in that the animal feed additive according to claim 1 in the form of pine bark or elm bark extract is contained in an amount corresponding to the administration of 0.002 to 100 g of pine bark extract or elm bark extract per day per animal. 18/20 • · • t • · ίδ '··· · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · 51531
    [8]
    A premix for producing an animal feed according to claim 3, characterized in that it comprises an animal feed additive according to claim 1 or 2 together with one or more feed components selected from the group consisting of protein carriers, carbohydrate carriers, roughage, silages, fats, vitamins, minerals and Trace elements.
    [9]
    9. Use of an animal feed additive according to claim 1 or a premix according to claim 8 for the preparation of an animal feed according to claim 3.
    [10]
    Use of ground pine or elm bark or pine bark or elm bark extract or a mixture thereof for the manufacture of an animal feed or animal feed additive or animal feed premix for the treatment or prophylaxis of acute or subacute rumen acidosis or rumen acidosis resulting from rumen acidosis.
    [11]
    11. Use according to claim 10, wherein the ruminant receives 0.1 to 500 g of ground pine bark or ground elm bark per day.
    [12]
    12. Use according to claim 10, wherein the ruminant receives from 0.002 to 100 g of pine bark extract or elm bark extract per day.
    [13]
    13. Use of ground pine or elm bark or pine bark or elm bark extract or a mixture thereof for the preparation of a drinking water additive for the treatment or prophylaxis of acute or subacute rumen acidosis or conditions resulting from rumen acidosis in a ruminant.
    [14]
    14. Use according to claim 13, wherein the drinking water additive contains 0.00008 g to 100 g of pine bark or elm bark extract per liter.

    Vienna, on August 20, 2012 19/20
    类似技术:
    公开号 | 公开日 | 专利标题
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    同族专利:
    公开号 | 公开日
    JP2015526082A|2015-09-10|
    AU2013304114A1|2015-04-02|
    JP6169177B2|2017-07-26|
    WO2014026965A1|2014-02-20|
    EP2884987B1|2019-02-27|
    KR20150041663A|2015-04-16|
    US20150208692A1|2015-07-30|
    AT513228B1|2016-05-15|
    EP2884987A1|2015-06-24|
    AU2013304114B2|2016-11-17|
    CN104661667A|2015-05-27|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    DE2258071A1|1972-11-27|1974-06-12|Erwin Schaefer|All-round foodstuff for excorticating game - providing nutrients minerals and active cpd. requirements|
    EP2085083A1|2008-01-09|2009-08-05|Exquim S.A.|Mixture of citric flavonoids to improve ruminal fermentation|
    WO2011127499A1|2010-04-15|2011-10-20|Klaus Neufeld|Animal feed additive having an antimicrobial and growth-promoting effect|
    JPH03982B2|1984-03-30|1991-01-09|Norinsuisansho Ringyo Shikenjocho|
    JP4064487B2|1997-02-15|2008-03-19|太陽化学株式会社|Preventive and therapeutic agents for livestock|
    JPH11318347A|1998-05-14|1999-11-24|Meiji Seika Kaisha Ltd|Meat quality improver containing fruit polyphenol as active ingredient|
    JP2002119221A|2000-10-12|2002-04-23|Kikkoman Corp|Constitution improver for horse and method for improving constitution of horse|
    CN100413857C|2004-02-13|2008-08-27|杭州利欣生物科技有限公司|Procyanidins oligomer and its preparing method and use|
    CN1613854A|2004-08-26|2005-05-11|上海交通大学|Extraction of oligomeric anthocyanin from pine bark|
    CN101474344B|2009-01-21|2011-09-07|中国农业科学院兰州畜牧与兽药研究所|Qi-moving dampness-drying spleen-strengthening medicament for sheep|
    JP5994964B2|2009-09-18|2016-09-21|日本製紙株式会社|Ruminant feed|
    SE535771C2|2010-07-01|2012-12-11|Perstorp Ab|Mycotoxin binding composition|CN105192312A|2015-09-18|2015-12-30|河北农业大学|Pig feed additive and preparation method thereof|
    CN107927365A|2017-11-30|2018-04-20|隆安县江泉牧业有限公司|Crop material preprocess method and its application in ammoniated forage is prepared|
    CN107950766A|2017-11-30|2018-04-24|隆安县江泉牧业有限公司|The preparation method of new disease-resistant ammoniated forage|
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    CN107927342A|2017-11-30|2018-04-20|隆安县江泉牧业有限公司|Ammonification roughage functional additive and its application|
    CN107950767A|2017-11-30|2018-04-24|隆安县江泉牧业有限公司|Cross Beef Cattle is with ammonification roughage and preparation method thereof|
    法律状态:
    2019-04-15| MM01| Lapse because of not paying annual fees|Effective date: 20180820 |
    优先权:
    申请号 | 申请日 | 专利标题
    AT8882012|2012-08-14|
    ATA904/2012A|AT513228B1|2012-08-14|2012-08-20|Animal feed or drinking water additive for ruminants|ATA904/2012A| AT513228B1|2012-08-14|2012-08-20|Animal feed or drinking water additive for ruminants|
    EP13748310.3A| EP2884987B1|2012-08-14|2013-08-13|Additive for animal food or drinking water for ruminants|
    KR20157006493A| KR20150041663A|2012-08-14|2013-08-13|Additive for animal food or drinking water for ruminants|
    CN201380043152.3A| CN104661667A|2012-08-14|2013-08-13|Additive for animal food or drinking water for ruminants|
    AU2013304114A| AU2013304114B2|2012-08-14|2013-08-13|Additive for animal food or drinking water for ruminants|
    JP2015526959A| JP6169177B2|2012-08-14|2013-08-13|Animal feed additives or drinking water additives for ruminants|
    PCT/EP2013/066872| WO2014026965A1|2012-08-14|2013-08-13|Additive for animal food or drinking water for ruminants|
    US14/624,027| US20150208692A1|2012-08-14|2015-02-17|Additive for animal food or drinking water for ruminants|
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