![]() DEVICE FOR PHOTOMETRIC OR BZW. SPECTROMETRIC STUDY OF A LIQUID SAMPLE
专利摘要:
Apparatus (1) for the photometric examination of a liquid sample, comprising a cuvette (3, 3 ') which can be arranged in the beam path between a radiation source (4) and a radiation detector (5) and which receives the liquid sample (2) to be examined, with a radiation-transmissive one Inlet section (6) for coupling in a radiation (20) generated by the radiation source (4), which interacts with a sample volume (8), and a radiation-permeable exit section (7) for coupling out a radiation intended for detection in the radiation detector (5) (20 ''), wherein the inlet section (6) has a convexly curved inlet surface (11) and / or the outlet section (7) has a convexly curved outlet surface (12, 12 ') such that the incident radiation (20) or ( 20 ') is bundled in the manner of a condenser lens. 公开号:AT510765A1 申请号:T2077/2010 申请日:2010-12-15 公开日:2012-06-15 发明作者:Wolfgang Dipl Ing Vogl 申请人:Wolfgang Dipl Ing Vogl; IPC主号:
专利说明:
1 The invention relates to a device for photometric or spectrometric examination of a liquid sample, with a cuvette which can be arranged in the beam path between a radiation source and a radiation detector and which receives the liquid sample to be examined, with a radiation-permeable inlet section for coupling in a radiation generated by the radiation source interacts with a sample volume, and a radiation-transmissive outlet section for coupling out a radiation intended for detection in the radiation detector. Such devices are used to perform analysis methods to qualitatively and quantitatively detect chemical parameters of liquid samples. The cuvette forms a liquid cell which receives the liquid sample to be examined. The sample is reacted with an appropriate reagent to cause changes in the optical properties of the solution, which can be measured photometrically. For this purpose, a radiation source is provided, which generates visible light, infrared light or ultraviolet light depending on the application. The cuvette has a transparent to the excitation radiation used entrance window for coupling the excitation radiation, which is coupled out after passing through the sample volume through the exit window. To carry out cuvette tests or the like, cuvettes with plane-parallel walls, on which the entry or exit window has been formed, have hitherto been used. In addition, a lens system is often provided in order to achieve a suitable beam deflection or shaping between the radiation source and the detector. In connection with a transmitted light refractometer, it is known, for example from DE 42 23 480 Al, to arrange a hollow cuvette in the telecentric beam path of a monochromatic light source, which generates a divergent beam which is shaped by means of a condenser into a parallel beam which, after passing through the cuvette of a lens is focused on a cellular sensor. Such devices allow a precise and specially adapted to the particular application deflection or imaging of the 2 Investigation provided radiation. Disadvantageously, such imaging systems are very costly; In addition, the installation and adjustment of the optical system is difficult and can often only be performed by a person skilled in the art. Moreover, there are a large number of interfaces which cause aberrations and power losses. In another context, DE 38 35 347 A1 describes a liquid cell with hemispherical ends, which is used by using stimulated scattering processes for laser amplification or phase conjugation. In contrast, the object of the present invention is to provide a structurally simple, inexpensive to produce device of the type mentioned, which allows a precise mapping of the excitation radiation used for the investigation of the liquid sample with little installation and adjustment. This is achieved in the device of the initially cited type in that the inlet section has such a convexly curved entrance surface and / or the outlet section has a convexly curved exit surface such that the incident radiation is concentrated in the manner of a condenser lens. Accordingly, at least one of the surfaces of the cuvette provided for coupling in and out of the radiation is convexly curved, so that bundling of the incident radiation, i. a reduction of the beam expansion, is achieved. In this way, the cuvette directly assumes tasks of the optical system, which previously was functionally and constructively separated from the cuvette. By incorporating essential elements of beamforming into the cuvette, a compact, low-cost photometric device can be provided which can be easily assembled and placed in the beam path between the radiation source and the radiation detector. The installation effort is thus significantly reduced; In addition, the adjustment over conventional devices with separate optical systems can be significantly simplified. X 3 The number of transition surfaces is significantly lower than with external optical systems, so that aberrations and power losses can be minimized. The device is therefore particularly suitable for rapid and inexpensive photometric or spectrometric examinations, which are not dependent on a complex, high-quality optical system, but on the other hand the simplest possible operation is desired. Preferably, both the entrance surface and the exit surface are convexly curved, so that together the effect of a bi-convex converging lens is achieved. Depending on the application, however, it is also conceivable that only the entrance surface or the exit surface is convexly curved; this arrangement is then comparable to a plano-convex converging lens. Of course, the invention should not be limited to cuvettes with a single entrance or exit surface; In particular, it is often desirable if the radiation beam on more than one Outlet section is coupled to gain additional information about the interacting with the sample volume radiation. The convexly curved entrance or exit surface may extend over the entire entrance or exit section of the cuvette; However, it is also conceivable that the inlet or outlet section is only partially convexly curved. The inlet and outlet sections preferably have coatings, which are expediently formed in each case by a λ / 4 layer. For the purpose of expedient beam formation in the region of the cuvette interfaces provided for coupling or decoupling the radiation, it is advantageous if the entrance surface and / or the exit surface is substantially spherically curved. The formation of the optically active areas, i. the entrance and / or exit surface, as spherically curved surfaces is to be preferred in terms of manufacturing technology; However, it is also conceivable to form the entrance or exit surface with an aspheric curvature, i. with a rotationally symmetrical shape, which, in contrast to spherical surfaces does not correspond to a section of a spherical surface. The additional degrees of freedom of spherical lenses can be used to reduce aberrations that occur when using spherical lenses Surfaces are inevitable. In a first preferred embodiment, provision is made for the cuvette to have a fluid cell that is substantially radiated in the direction of its longitudinal extension axis, in particular a substantially cylindrical fluid cell, wherein an end face of the fluid cell is formed as a convexly curved entry or exit surface. The end faces of the cuvettes are arranged in particular substantially transversely to the longitudinal axis of the cuvette. If both end faces are convexly curved, a suitable irradiation of the liquid sample can be achieved. This embodiment has the advantage that the radiation in the cuvette covers a comparatively large distance and thus a large interaction volume is provided, which allows an investigation of the chemical parameters, for example the concentration of a certain proportion of solution, with high accuracy. Expediently, the end faces of the in particular substantially cylindrical liquid cell are curved in such a way that the excitation radiation is concentrated in a substantially parallel bundle of rays along the longitudinal extension axis of the cuvette, which substantially completely passes through the solution stored in the liquid cell. In a further preferred embodiment, it is advantageous if the cuvette has a substantially in a direction transversely to its longitudinal axis irradiated, in particular substantially cylindrical liquid cell, on whose lateral surface, the convexly curved entrance and / or exit surface is formed. Accordingly, here convexly or outwardly curved entry or exit surfaces are provided by the lateral surface of the liquid cell. If the cuvette is designed as a flow cuvette having a supply line and a discharge for the liquid sample to be examined, a continuous investigation of the chemical or physical processes can take place. This makes it possible, in particular, to continuously record changes in chemical parameters such as concentrations, etc. 5 In order to avoid air pockets in the liquid sample, it is favorable if the supply line is connected to the cuvette with respect to an operating position of the cuvette in the vertical direction below the discharge, wherein the discharge line is preferably connected to an upper-side section of the cuvette. Accordingly, the liquid sample is fed from below and discharged further above, whereby the formation of air bubbles, which can interfere with the investigation, reliably avoided or at least significantly reduced. For this purpose, it is particularly advantageous if the discharge is connected to the top of the cuvette, so that the liquid sample is discharged at the highest point in the vertical direction. With regard to improved mixing of the flüssiguen sample and favorable flow conditions, it is advantageous if a longitudinal axis of the feed line and / or a longitudinal axis of the derivative with respect to a longitudinal axis and / or a transverse axis of the flow cuvette is inclined. In an alternative embodiment of the flow cell, improved flow conditions may be achieved by having the lead and / or the lead having portions with different cross-sectional areas. For many applications, in particular flow cytometry and related measurement methods, it is advantageous if the cuvette has at least one convexly curved exit surface for a forwardly scattered beam and another convexly curved exit surface for a laterally scattered beam. Flow cytometry is based on the emission of optical radiation from a cell exposed to high intensity radiation generated, for example, by a laser beam source. From the scattered light can be closed on the size and shape of the cell. The forward scattered light (FSC = Forward Scatter), i. the light diffracted at small angles depends in particular on the cell volume. The transversely scattered beam, commonly referred to as sideward scattered light (SSC), gives particular attention to granularity, size, and I Structure of the cell or of cell components Information. A comparison of forward scattered light and side scattered light makes it possible, for example, to differentiate between different blood cells. To perform the flow cytometry, it is advantageous if the cuvette has a narrow channel through which the cell suspension is passed in a very thin beam. The invention further relates to a device which has a radiation source, in particular a light-emitting diode (LED), which is set up in particular to produce a divergent beam, and a radiation detector, preferably a charge coupled device (CCD) sensor. Of course, depending on the application, other types of radiation sources, in particular a continuous radiation source may be provided; if a high intensity is required, a laser source can also be used in particular. However, the use of light-emitting diodes is often preferred, as these represent a very cost-effective design, which are also generally available for most wavelength ranges. The CCD camera is preferably set up to detect the transmitted radiation, which contains information about the liquid sample, substantially along the entire length of the cuvette. Conveniently, a reference sensor for calibrating the radiation detector is provided. For carrying out photometric investigations with high metrological resolution, it is advantageous if the convexly curved entrance surface bundles a divergent beam bundle into a substantially parallel beam bundle which, after passing through the sample volume, is converged by means of the convexly curved exit surface into a convergent beam bundle the radiation detector is detectable. Thus, a comparatively large sample volume is irradiated, whereby the metrological resolution, which depends on the sample volume, is increased. The lens system integrated in the cuvette therefore makes it possible to adapt the irradiated sample volume specifically to the requirements imposed on the analysis method, in particular with regard to the achievable resolution. In addition, by radiating a comparatively large sample volume, the exposure of the sample to the radiation can be considerably reduced, which is of great importance, in particular, when examining organic samples, for example by means of ultraviolet (UV) light. In a further preferred embodiment of the invention, it is provided that the entrance surface of the cuvette is curved in such a way that the radiation impinging on the entry surface is focused in a comparatively small focus region of the liquid sample; this is achieved by a comparatively small radius of curvature of the entrance surface. This design makes it possible in a structurally simple manner to introduce a high energy density in the focus region of the liquid sample to be examined. The provision of a high energy density is essential for many applications, for example in flow cytometry. Accordingly, radiation of comparatively low intensity can be used to excite the sample volume, which is focused by means of the entrance surface curved in the manner of a converging lens in order to achieve the required energy density in the sample volume. This allows the use of light emitting diodes as a radiation source, which are characterized by their low cost and wide distribution with different wavelengths. The chosen radius of curvature of the entrance surface expediently depends on the shape or widening of the incident radiation, which may be in the form of a divergent or parallel bundle of rays. The invention will be explained below with reference to preferred embodiments illustrated in the drawings, to which, however, it should not be restricted. In detail, in the drawing: 1 is a view of a device for photometric or spectrometric examination of a liquid sample by means of a cuvette, wherein the inlet or outlet section for the excitation radiation according to the prior art is formed on plane-parallel side walls of the cuvette. FIG. 2 shows a view of a device for photometric or spectrometric examinations, which, according to a first embodiment of the invention, is designed as a through-flow through-flow cuvette with convexly curved end faces; FIG. 3 shows a view of a device for photometric or spectrometric examinations with a cuvette, which is transversely irradiated according to a further embodiment of the invention, wherein the convexly curved entrance or exit window is formed on the lateral surface of the cuvette; 4 shows a view of a device for photometric or spectrometric examinations with a cuvette, which according to a further embodiment of the invention concentrates the excitation radiation in a small focus area by means of the convexly curved entrance window; Fig. 5 is a view of a device for photometric or spectrometric investigations in the manner of flow cytometry, wherein the cuvette formed according to a further embodiment of the invention comprises two convexly curved exit windows which decouple the forward scattered light and the side scattered light; FIGS. 6 and 7 each show a view of a flow cell according to a further embodiment of the invention, which has a feed line or discharge improved with respect to the flow conditions; 8 is a view of a flow cell with an alternative embodiment of the inlet and outlet; 9 shows a view of an arrangement for photometric or spectrometric investigations with a dichroic mirror and a reference sensor; 10 shows a view of an alternative arrangement for photoreactic or spectrometric examinations with a semitransparent mirror. • k fr # «kl» »fr fr - 9 - Fig. 1 shows a prior art apparatus 1 for the photometric determination of a chemical parameter of a liquid sample 2 having a solution to be tested, which is reacted with a suitable reagent to cause a change in the optical properties of the solution , which can be measured photometrically. The chemical parameter may be, for example, the concentration. Photometry is based on the measurement of optical properties of radiation passing through the liquid sample 2. In a simple case, the absorption of the radiation can be used as a measure of the sought concentration of a solution fraction. In other cases, the scattering or diffraction behavior is detected. Alternatively or in addition to the photometric examination of the liquid sample 2, spectometric measurements can be made. The device 1 has a cuvette 3, which is arranged between a radiation source 4 for generating a radiation suitable for the photometric examination and a radiation detector 5 for detecting the transmitted radiation. The cuvette 3 has, on a wall facing the radiation source 4, an inlet section 6 for coupling in an excitation radiation generated by means of the radiation source 4; In addition, an outlet section 7 is provided on an opposite wall of the cuvette 3, through which the radiation which has interacted with a sample volume 8 of the liquid sample 2 is decoupled. The transmitted radiation impinges on the radiation detector 5, which determines the sought chemical parameter of the liquid sample 2 from the measured physical quantity, in particular from the radiation intensity of the transmitted radiation. The cuvette 3 shown in Fig. 1 is formed according to the prior art with plane-parallel walls. As can be seen from FIG. 1, only a very small sample volume 8 is measured with this cuvette 3, the majority of the excitation radiation not reaching the radiation detector 5. In Fig. 1, an illuminated surface 9 is schematically drawn, which is greater by a multiple than an excitation cross section 10 of the excitation radiation, which is continuously fanned between the radiation source 4 and the radiation detector 5. Thus, only a fraction of the excitation energy is used to examine the liquid sample 2. The signal strength at the radiation detector 5 is essentially determined by the intensity of the excitation radiation and the ratio between the illuminated surface 9 and the sensor surface. In the arrangement shown, therefore, only a comparatively small signal strength is achieved, which is associated with a low resolution, which may not be sufficient to determine small concentrations. In the prior art, therefore, often complicated lens systems (not shown in FIG. 1) are used, which provide a suitable mapping of the excitation radiation, aimed at increasing the effective sample volume 8 or the radiation detector 5 impinging on the signal used for the investigation , However, additional optical components, such as condenser or objective lenses, are expensive to manufacture. In addition, the adjustment of these lenses is difficult because the placement of the lenses must be precisely aligned with the cuvette 3 in order to achieve the desired radiation deflection or bundling. In the case of the cuvette 3 shown in FIG. 2 in a first embodiment of the invention, on the other hand, the inlet section 6 has a convexly curved entry surface 11, which bundles the radiation impinging on the convex entry surface 11 in the manner of a converging lens. Correspondingly, the exit section 7 of the cuvette 3 has a convexly curved exit surface 12 in order to bundle the transmitted radiation during the coupling out of the cuvette 3. The convex curvature of the entry surface 11 and the exit surface 12 is related to the inner cavity of the cuvette 3, with respect to which the entry 11 and exit surface 12 is curved outwardly. The convexly curved entry surface 11 or exit surface 12 accordingly causes a bundling of the radiation impinging on the respective surface, so that the fanning out of the radiation beam is reduced. The cuvette 3 therefore takes over directly the tasks of an optical system, which was formed in previous devices 1 by separate optical components. The beam shaping is thus achieved by the convexly curved entrance 11 or exit area i i t t 11 12 integrated in the cuvette 3, so that a compact photometric device 1 is provided without costly installation and adjustment, without additional expensive optical components comes from. This is particularly advantageous for applications with excitation radiation in the ultraviolet (UV) or infrared (IR) range, which require special glasses that are particularly expensive and expensive to manufacture. The cuvette 3 shown in Fig. 2 is formed by an elongated, substantially cylindrical liquid cell 13 which is irradiated in the direction of its longitudinal axis 14. This cuvette 3 has two transverse to the longitudinal axis 14 arranged end faces 15, which form the convexly curved entrance surface 11 and the convexly curved exit surface 12. The cuvette 3 is designed as a flow-through cuvette 3 ', which has a feed line 16, via which the liquid sample 2 is introduced into the liquid cell 13. In addition, the cuvette 3 has a discharge line 17, via which the examined liquid sample 2 is discharged from the liquid cell 13. The flow cuvette 3 'allows a continuous investigation of chemical parameters of the liquid sample 2. As shown in Fig. 2 further seen, the liquid sample 2 in the direction of arrow 18 from below, based on the operating position of the cuvette 3, is introduced into the liquid cell 13 and after passing through the liquid cell 13 upwards through the discharge line 17. By this arrangement, the formation of air pockets, which complicate the investigation of the liquid sample 2, significantly reduced. For this purpose, provision is made in particular for the discharge line 17 to be connected to an uppermost point of the flow cell 3 'with respect to the operating position in the vertical direction. The radiation source 4, which is expediently designed as a cost-effective light-emitting diode (LED) 19 available for the most varied wavelengths, generates a divergent beam 20, which is bundled by means of the convexly curved entrance surface 11 into a substantially parallel beam 20 ', with respect to conventional arrangements significantly larger sample volume 8 is penetrated by the excitation radiation. The substantially parallel beam 20 'becomes 12 Passing through the sample volume 8 by means of the convexly curved exit surface 12 in a convergent beam 20 '' focused, which is focused on the sensor surface of the radiation detector 5. Accordingly, the excitation radiation is used very efficiently, wherein essentially the entire content of the liquid cell 13 is measured as sample volume 8. In Fig. 3, an alternative embodiment of the device 1 is shown, in which the cuvette 3 has a substantially in a direction transverse to its longitudinal axis 21 irradiated liquid cell 13 '. The fluid cell 13 'may be cylindrical or generally cuboidal. Depending on the application, the cuvette 3 can be designed as a flow-through cuvette 3 'or as a cuvette, in which the reagent is introduced into the cuvette 3 before the examination. The convexly curved inlet 11 or outlet surface 12 is in each case formed on a lateral surface 22 of the cuvette 3. In this embodiment as well, the effect of a converging lens, especially of a bi-convex converging lens, is achieved by the convexly curved entry or exit surface 12 in order to achieve a suitable imaging of the excitation radiation through the cuvette 3. FIG. 4 shows a further embodiment of the device 1 according to the invention, in which the cuvette 3 has a larger convex curvature than the preceding embodiments, so that the divergent excitation radiation is bundled directly into a convergent radiation beam when coupled into the cuvette 3 comparatively small focus area 23 in the sample volume 8 has. By this embodiment, a very high energy density can be transferred to the sample volume 8, which has the advantage that instead of the laser usually used as a radiation source 4, a comparatively inexpensive light emitting diode 19 can be used. In Fig. 5, finally, an embodiment of the device 1 is shown, which corresponds to the embodiment shown in FIG. 4, wherein a second convexly curved exit window 12 'can be seen, which is arranged substantially perpendicular to the entry surface 11 and to the exit surface 12. The- »** · if **» * * · · * · · «· - 13 -se version of the cuvette 3 enables the implementation of analysis methods in the type of flow cytometry. In this case, a scattered in the forward direction beam or forward scattered light 24 is coupled via the exit surface 12 and detected with a forward scattered light detector 26. In addition, a beam scattered in the transverse direction or side scattered light 25 is coupled out via the exit surface 12 'and detected with a side-down scattered-light detector 27. With the flow cytometry, for example, cell suspensions are examined, which are passed in a thin beam through a channel 28 of the cuvette 3 (see also Fig. 4). The radius of curvature of the convexly curved entry or exit surface 11 or 12 is to be adapted to the desired concentration of the excitation radiation or the transmitted radiation, depending on the application. With a view to cost-effective production, spherically curved inlet 11 and outlet surface (s) 12, 12 'are expedient. For applications with high image accuracy requirements, it may be beneficial to avoid lens flaws if the entrance 11 or exit surface (s) 12, 12 'are aspherical surfaces. 6 and 7 show in a longitudinal view and a cross-sectional view of a flow cell 3 ', which has a favorable in terms of flow conditions in the liquid cell 13 form the supply line 16 and discharge 17. As can be seen from FIG. 6, a longitudinal extension axis 16 'of the supply line 16 and a longitudinal extension axis 17' of the discharge line 17 are each inclined relative to the longitudinal extension axis 14 of the liquid cell 13. As can be seen from FIG. 7, the longitudinal extension axis 16 'of the supply line 16 and the longitudinal extension axis 17' of the discharge line 17 are each arranged at an inclination angle to a transverse axis 29 of the liquid cell 13. In this embodiment, the liquid sample 2 is substantially in or out tangentially into the liquid cell 13, thereby providing improved mixing of the liquid sample 2 and reducing turbulence in the liquid stream. FIG. 8 shows an alternative embodiment of the through-flow cage 3 'in which the supply line 16 and the discharge line 17 each have two sections 16a, 16b and 17a, 17b with different cross-sectional areas. Accordingly, the feed line 16 has a section 16 which extends in the direction of the longitudinal axis 14 of the liquid cell 13 and opens into a section 16b arranged at right angles thereto with an enlarged cross section relative to the section 16a through which the liquid sample 2 is introduced into the liquid cell 13. The portion 17b of the discharge line 17 adjoining the liquid cell 13 has a larger cross section than the downstream portion 17a of the discharge line 17, which adjoins the portion 17b of the discharge line 17 in the longitudinal direction. 9 shows schematically an arrangement for carrying out photometric or spectrometric examinations with a cuvette 3 containing a liquid sample 2, a radiation source 4 and two separate radiation detectors 5 which detect different or complementary interactions of the coupled radiation with the liquid sample 2. For calibrating the measurement signal, a reference sensor 30 is additionally provided. In the arrangement shown in FIG. 9, a dichroic mirror 31 is provided for dividing the radiation emitted by the radiation source 4, which reflects part of the light spectrum in the direction of the inlet section 6 and transmits the remaining wavelength ranges. 10 shows an alternative arrangement for carrying out photometric or spectrometric examinations which, instead of the dichroic mirror 31 shown in FIG. 9, provides a semitransparent mirror 32 which directs a portion of the radiation emitted by the radiation source 4 into the reference sensor 30, wherein the transmitted portion of the radiation impinges on the convexly curved end face 15 of the inlet section 6. For detecting the radiation which has interacted with the liquid sample 2, radiation detectors 5 arranged in the region of the inlet section 6 or in the region of the outlet section 7 are arranged.
权利要求:
Claims (13) [1] 1. Device (1) for the photometric or spectrometric examination of a liquid sample (2), with a in the beam path between a radiation source (4) and a radiation detector (5) can be arranged cuvette (3, 3 ') / which to be examined liquid sample (2) receives, with a radiation-permeable inlet portion (6) for coupling a radiation generated by the radiation source (4) radiation (20), which interacts with a sample volume (8), and a radiation-transmissive outlet portion (7) for decoupling a for detection in the radiation detector (5) provided radiation (20 ''), characterized in that the inlet portion (6) such a convexly curved entrance surface (11) and / or the outlet portion (7) such a convexly curved exit surface (12, 12 ' ), that the incident radiation (20) or (20 ') is focused in the manner of a converging lens. [2] 2. Device (1) according to claim 1, characterized in that the entry surface (11) and / or the exit surface (12, 12 ') is curved substantially spherically. [3] 3. Device (1) according to claim 1 or 2, characterized in that the cuvette (3, 3 ') has a substantially in the direction of its longitudinal extension axis (14) irradiated, in particular substantially cylindrical fluid cell (13), wherein an end face ( 15) of the liquid cell (13) is designed as a convexly curved entry (11) or exit surface (12). [4] 4. Device (1) according to claim 1 or 2, characterized in that the cuvette (3, 3 ') has a substantially in a direction transverse to its longitudinal extension axis (21) irradiated, in particular substantially cylindrical fluid cell (13'}, on the lateral surface (22) of the convexly curved entrance and / or exit surface is formed. [5] 5. Device (1) according to one of claims 1 to 4, characterized in that the cuvette (3, 3 '} as a flow-through cuvette • »♦ • ··· ·· ♦ • *« • ♦ • • • • • Is formed (3 '), which has a feed line (16) and a discharge line (17) for the liquid sample (2) to be examined. [6] 6. Device (1) according to claim 5, characterized in that the supply line (16) with respect to an operating position of the cuvette (3 '} in the vertical direction below the discharge line (17) to the cuvette (3') is connected, wherein the derivative (17) is preferably connected to an upper-side portion of the cuvette (3 '). [7] 7. Device (1) according to claim 5 or 6, characterized in that a longitudinal extension axis (16 ') of the feed line (16) and / or a longitudinal extension axis (17') of the discharge line (17) with respect to a longitudinal axis (14) and / or a transverse axis (29) of the flow cell (3 ') is inclined. [8] 8. Device (1) according to claim 5 or 6, characterized in that the supply line (16) and / or the discharge line (17) has sections (16a, 16b) or (17a, 17b) with different cross-sectional areas. [9] 9. Device (1) according to one of claims 1 to 8, characterized in that the cuvette (3, 3 ') at least one convexly curved exit surface (12) for a forward scattered beam (24) and a further convexly curved exit surface ( 12 ') for a transversely scattered beam (25). [10] 10. Device (1) according to one of claims 1 to 9, characterized in that a particular for generating a divergent beam set up radiation source (4), preferably a light emitting diode (19), and a radiation detector (5), preferably a CCD sensor , are provided. [11] 11. Device (1) according to claim 10, characterized in that a reference sensor (30) for calibrating the radiation detector (5) is provided. [12] 12. Device (1) according to one of claims 1 to 11, characterized in that the convexly curved entry surface (11). In particular, a divergent beam (20) bundles into a substantially parallel beam (20 '), which after Passing through the sample volume (8) by means of the convexly curved exit surface (12, 12 ') in a convergent beam (20' ') is bundled, which is detectable with the radiation detector (5). [13] 13. Device (1) according to one of claims 1 to 12, characterized in that the entry surface (11) of the cuvette (3, 3 ') is curved in such a way that the incident on the entrance surface (11) radiation (20) in one comparatively small focus area (23) of the liquid sample is focused.
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同族专利:
公开号 | 公开日 WO2012079103A3|2012-08-16| ZA201304438B|2014-03-26| BR112013015152A2|2020-08-11| US20130265580A1|2013-10-10| IL226889A|2017-01-31| RU2013126559A|2015-01-20| CA2820995C|2020-06-09| CA2820995A1|2012-06-21| AT510765B1|2012-09-15| JP5990185B2|2016-09-07| EP2652481A2|2013-10-23| WO2012079103A2|2012-06-21| AP2013006964A0|2013-07-31| CN103270405A|2013-08-28| US9347870B2|2016-05-24| RU2593623C2|2016-08-10| JP2014501382A|2014-01-20| CN103270405B|2017-01-18|
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法律状态:
2013-10-15| PC| Change of the owner|Owner name: VWM GMBH, AT Effective date: 20130823 | 2021-07-15| PC| Change of the owner|Owner name: VWMS INVENTIONS GMBH, AT Effective date: 20210525 |
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申请号 | 申请日 | 专利标题 ATA2077/2010A|AT510765B1|2010-12-15|2010-12-15|DEVICE FOR PHOTOMETRIC OR BZW. SPECTROMETRIC STUDY OF A LIQUID SAMPLE|ATA2077/2010A| AT510765B1|2010-12-15|2010-12-15|DEVICE FOR PHOTOMETRIC OR BZW. SPECTROMETRIC STUDY OF A LIQUID SAMPLE| CA2820995A| CA2820995C|2010-12-15|2011-12-15|Device for photometrically or spectrometrically examining a liquid sample| PCT/AT2011/000497| WO2012079103A2|2010-12-15|2011-12-15|Device for photometrically or spectrometrically examining a liquid sample| AP2013006964A| AP2013006964A0|2010-12-15|2011-12-15|Device for photometrically or spectrometrically examining a liquid sample| BR112013015152-8A| BR112013015152A2|2010-12-15|2011-12-15|device for photometric or spectrometric examination of liquid sample| CN201180060724.XA| CN103270405B|2010-12-15|2011-12-15|Device for photometrically or spectrometrically examining a liquid sample| EP11813650.6A| EP2652481A2|2010-12-15|2011-12-15|Device for photometrically or spectrometrically examining a liquid sample| RU2013126559/28A| RU2593623C2|2010-12-15|2011-12-15|Device for photometric or spectrometric analysis of liquid sample| US13/993,372| US9347870B2|2010-12-15|2011-12-15|Device for photometrically or spectrometrically examining a liquid sample| JP2013543465A| JP5990185B2|2010-12-15|2011-12-15|Equipment for photometric or spectroscopic inspection of liquid samples| IL226889A| IL226889A|2010-12-15|2013-06-12|Device for photometrically or spectrometrically examining a liquid sample| ZA2013/04438A| ZA201304438B|2010-12-15|2013-06-14|Device for photometrically or spectrometrically examining a liquid sample| 相关专利
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